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High Altitude Medicine & Biology

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https://www.readbyqxmd.com/read/29757001/exhaled-nitric-oxide-changes-during-acclimatization-to-high-altitude-a-descriptive-study
#1
Douglas T Summerfield, Kirsten E Coffman, Bryan J Taylor, Amine N Issa, Bruce D Johnson
Summerfield, Douglas T., Kirsten E. Coffman, Bryan J. Taylor, Amine N. Issa, and Bruce D. Johnson. Exhaled nitric oxide changes during acclimatization to high altitude: a descriptive study. High Alt Med Biol. 00:000-000, 2018. AIMS: This study describes differences in the partial pressures of exhaled nitric oxide (PeNO) between subjects fully acclimatized (ACC) to 5300 m and those who have just arrived to high altitude. METHODS: PeNO was determined in eight subjects newly exposed and nonacclimatized (non-ACC) to high altitude and compared with that in nine subjects who had ACC to high altitude for 1 month...
May 14, 2018: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/29741971/impact-of-sleeping-altitude-on-symptoms-of-acute-mountain-sickness-on-mt-fuji
#2
Masahiro Horiuchi, Tadashi Uno, Junko Endo, Yoko Handa, Tatsuya Hasegawa
Horiuchi, Masahiro, Tadashi Uno, Junko Endo, Yoko Handa, and Tatsuya Hasegawa. Impact of sleeping altitude on symptoms of acute mountain sickness on Mt. Fuji. High Alt Med Biol. 00:000-000, 2018. AIMS: We sought to investigate the factors influencing acute mountain sickness (AMS) on Mt. Fuji in Japan, in particular, to assess the effects of sleeping altitude, by means of a questionnaire survey. This study involved 1932 participants who climbed Mt. Fuji, and obtained information regarding sex, age, and whether participants stayed at the mountain lodges...
May 9, 2018: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/29733223/coping-with-hypoxia-at-high-altitude-how-lung-blood-and-brain-respond-and-cross-talk-5th-international-atacama-leh-symposium-in-san-pedro-de-atacama-march-4-9-2018-chile
#3
Edith M Schneider Gasser, Nuria Fabregas Bregolat, Markus Thiersch
No abstract text is available yet for this article.
May 7, 2018: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/29717894/amputees-at-high-altitude-the-potentially-sticky-issue-of-thrombophilia
#4
Benjamin S Stacey, Lewis Fall, David Shearer, Martin Steggall, Ian W Williams, Michael H Lewis, Damian Miles Bailey
No abstract text is available yet for this article.
May 2, 2018: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/29683363/cardiovascular-autonomic-response-to-orthostatic-stress-under-hypoxia-in-patients-with-spinal-cord-injury
#5
Shu-Chun Huang, Kuo-Cheng Liu, Alice M K Wong, Shih-Chieh Chang, Jong-Shyan Wang
Huang, Shu-Chun, Kuo-Cheng Liu, Alice M.K. Wong, Shih-Chieh Chang, and Jong-Shyan Wang. Cardiovascular autonomic response to orthostatic stress under hypoxia in patients with spinal cord injury. High Alt Med Biol. 00:000-000, 2018. AIMS: Determining whether systemic hypoxia aggravates the severity of autonomic cardiovascular dysfunction in orthostatic stress among patients with spinal cord injuries (SCIs). METHODS: Twenty-four male patients with chronic SCI whose neurological levels were above T6 were recruited...
April 23, 2018: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/29630402/prostatic-specific-antigen-levels-in-men-from-two-andean-cities-of-peru
#6
Diana E Alcantara-Zapata, Gustavo F Gonzales, Paulina Pino
No abstract text is available yet for this article.
April 9, 2018: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/29620950/a-systematic-review-and-meta-analysis-reveals-altered-drug-pharmacokinetics-in-humans-during-acute-exposure-to-terrestrial-high-altitude-clinical-justification-for-dose-adjustment
#7
Damian Miles Bailey, Benjamin S Stacey, Mark Gumbleton
OBJECTIVE: While physiological responses during acute ascent to terrestrial high altitude (HA) have the potential to alter the pharmacokinetics (PKs) that define absorption and disposition of medicinal drugs, there have been no systematic reviews and meta-analyses performed to date. METHODS: We conducted a systematic literature search in June 2017 using NCBI PubMed, EMBASE, Web of Science, and Ovid MEDLINE databases to identify relevant observational studies. Studies were deemed eligible based on the following criteria: (1) participants: healthy, nonacclimatized male or female lowlanders (born and bred at sea level) and (2) environment: exposure to low altitude (LA, ≤600 m), followed by terrestrial high altitude (HA, ≤24 hours to ≥2500 m), the time course specifically selected to avoid interpretive complications associated with erythrocytosis...
April 5, 2018: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/29608374/exploration-of-acute-phase-proteins-and-inflammatory-cytokines-in-early-stage-diagnosis-of-acute-mountain-sickness
#8
Chi Wang, Hui Jiang, Jinyan Duan, Jingwen Chen, Qi Wang, Xiaoting Liu, Chengbin Wang
Wang, Chi, Hui Jiang, Jinyan Duan, Jingwen Chen, Qi Wang, Xiaoting Liu, and Chengbin Wang. Exploration of acute phase proteins and inflammatory cytokines in early stage diagnosis of acute mountain sickness. High Alt Med Biol. 00: 000-000, 2018. BACKGROUND: Early diagnosis of acute mountain sickness (AMS) is currently based on personal appreciation of the severity of symptoms. A more objective method to diagnose AMS is required. Inflammatory cytokines and acute phase proteins have been reported to be different at high altitude...
April 2, 2018: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/29608373/cold-susceptibility-of-digit-stumps-resulting-from-amputation-after-freezing-cold-injury-in-elite-alpinists
#9
Jurij Gorjanc, Shawnda A Morrison, Rok Blagus, Igor B Mekjavic
Gorjanc, Jurij, Shawnda A. Morrison, Rok Blagus, and Igor B. Mekjavic. Cold susceptibility of digit stumps resulting from amputation after freezing cold injury in elite alpinists. High Alt Med Biol. 16: 000-000, 2018. AIM: The aim of the study was to assess whether previous freezing cold injury in fingers and/or toes might predispose alpinists to greater risk of further freezing cold injury, primarily due to a greater vasoconstrictor response to cold, resulting in a lower perfusion, reflected in lower skin temperature...
April 2, 2018: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/29565692/a-case-of-subacute-infantile-mountain-sickness-in-a-kyrgyz-child
#10
Kubatbek Muratali Uulu, Meerim Cholponbaeva, Melis Duishobaev, Aidana Toktosunova, Abdirashit Maripov, Akylbek Sydykov, Akpay Sarybaev
Muratali Uulu, Kubatbek, Meerim Cholponbaeva, Melis Duishobaev, Aidana Toktosunova, Abdirashit Maripov, Akylbek Sydykov, and Akpay Sarybaev. A case of subacute infantile mountain sickness in a Kyrgyz child. High Alt Med Biol. 00: 000-000, 2018.-Subacute infantile mountain sickness (SIMS) is a syndrome of severe pulmonary hypertension and right heart failure that develops in infants born in the lowlands and subsequently brought to live at high altitudes. Earlier postmortem studies have demonstrated significant remodeling of small pulmonary arteries as well as right ventricular hypertrophy and dilatation...
March 22, 2018: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/29565678/chronic-intermittent-hypobaric-hypoxia-4600-m-attenuates-pulmonary-vasodilation-induced-by-acetylcholine-or-sodium-nitroprusside
#11
Fernando A Moraga, Giselle Miranda, Vasthi López, Carmen Vallejos, Daniel Silva
Moraga, Fernando A., Giselle Miranda, Vasthi López, Carmen Vallejos, and Daniel Silva. Chronic intermittent hypobaric hypoxia (4600 M) attenuates pulmonary vasodilation induced by acetylcholine or sodium nitroprusside. High Alt Med Biol. 00: 000-000, 2018. BACKGROUND: Previous studies performed in rats exposed to chronic intermittent hypobaric hypoxia (CIHH), at a simulated altitude of 4600 m, showed reduced nitric oxide (NO) production, increased arginase activity, and increased oxidative stress...
March 22, 2018: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/29641295/electronic-nose-technology-fails-to-sniff-out-acute-mountain-sickness
#12
Remco R Berendsen, Marieke E van Vessem, Marcel Bruins, Luc J S M Teppema, Leon P H J Aarts, Bengt Kayser
Berendsen, Remco R., Marieke E. van Vessem, Marcel Bruins, Luc J.S.M. Teppema, Leon P.H.J. Aarts, and Bengt Kayser. Electronic nose technology fails to sniff out acute mountain sickness. High Alt Med Biol. 00:000-000, 2018. AIM: The aim of the study was to evaluate whether an electronic nose can discriminate between individuals with and without acute mountain sickness (AMS) following rapid ascent to 4554 m. RESULTS: We recruited recreational climbers (19 women, 82 men; age 35 ± 10 years, mean ± standard deviation [SD]) upon arrival at 4554 m (Capanna Regina Margherita, Italy) for a proof of concept study...
March 20, 2018: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/29641294/adaptive-servoventilation-as-treatment-for-central-sleep-apnea-due-to-high-altitude-periodic-breathing-in-nonacclimatized-healthy-individuals
#13
Jeremy E Orr, Erica C Heinrich, Matea Djokic, Dillon Gilbertson, Pamela N Deyoung, Cecilia Anza-Ramirez, Francisco C Villafuerte, Frank L Powell, Atul Malhotra, Tatum Simonson
Orr, Jeremy E., Erica C. Heinrich, Matea Djokic, Dillon Gilbertson, Pamela N. Deyoung, Cecilia Anza-Ramirez, Francisco C. Villafuerte, Frank L. Powell, Atul Malhotra, and Tatum Simonson. Adaptive servoventilation as treatment for central sleep apnea due to high-altitude periodic breathing in nonacclimatized healthy individuals. High Alt Med Biol. 18:000-000, 2018. AIMS: Central sleep apnea (CSA) is common at high altitude, leading to desaturation and sleep disruption. We hypothesized that noninvasive ventilation using adaptive servoventilation (ASV) would be effective at stabilizing CSA at altitude...
March 13, 2018: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/29583031/the-2018-lake-louise-acute-mountain-sickness-score
#14
Robert C Roach, Peter H Hackett, Oswald Oelz, Peter Bärtsch, Andrew M Luks, Martin J MacInnis, J Kenneth Baillie
Roach, Robert C., Peter H. Hackett, Oswald Oelz, Peter Bärtsch, Andrew M. Luks, Martin J. MacInnis, J. Kenneth Baillie, and The Lake Louise AMS Score Consensus Committee. The 2018 Lake Louise Acute Mountain Sickness Score. High Alt Med Biol 00:000-000, 2018.- The Lake Louise Acute Mountain Sickness (AMS) scoring system has been a useful research tool since first published in 1991. Recent studies have shown that disturbed sleep at altitude, one of the five symptoms scored for AMS, is more likely due to altitude hypoxia per se, and is not closely related to AMS...
March 13, 2018: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/29596018/the-star-data-reporting-guidelines-for-clinical-high-altitude-research
#15
Monika Brodmann Maeder, Hermann Brugger, Matiram Pun, Giacomo Strapazzon, Tomas Dal Cappello, Marco Maggiorini, Peter Hackett, Peter Bärtsch, Erik R Swenson, Ken Zafren
Brodmann Maeder, Monika, Hermann Brugger, Matiram Pun, Giacomo Strapazzon, Tomas Dal Cappello, Marco Maggiorini, Peter Hackett, Peter Baärtsch, Erik R. Swenson, Ken Zafren (STAR Core Group), and the STAR Delphi Expert Group. The STARdata reporting guidelines for clinical high altitude research. High AltMedBiol. 19:7-14, 2018. AIMS: The goal of the STAR (STrengthening Altitude Research) initiative was to produce a uniform set of key elements for research and reporting in clinical high-altitude (HA) medicine...
March 2018: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/29470103/an-approach-to-children-with-pulmonary-edema-at-high-altitude
#16
Deborah R Liptzin, Steven H Abman, Ann Giesenhagen, D Dunbar Ivy
Liptzin, Deborah R., Steven H. Abman, Ann Giesenhagen, and D. Dunbar Ivy. An approach to children with pulmonary edema at high altitude. High Alt Med Biol. 19:91-98, 2018. INTRODUCTION: Diagnosis of high-altitude illness can be more challenging in children, especially those who are preverbal. Families often travel to high elevations for family vacations, either for skiing, hiking, and/or camping. They may present to their primary care providers looking for anticipatory guidance before travel or may follow-up after developing high-altitude illness...
March 2018: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/29443612/elevated-vasodilatory-cyclases-and-shorter-telomere-length-contribute-to-high-altitude-pulmonary-edema
#17
Manjari Rain, Himanshi Chaudhary, Ritushree Kukreti, Tashi Thinlas, Ghulam Mohammad, Qadar Pasha
Rain, Manjari, Himanshi Chaudhary, Ritushree Kukreti, Tashi Thinlas, Ghulam Mohammad, and Qadar Pasha. Elevated vasodilatory cyclases and shorter telomere length contribute to high-altitude pulmonary edema. High Alt Med Biol. 19:60-68, 2018. AIM: High-altitude (HA) genetics is complex with respect to health and disease (HA pulmonary edema i.e., HAPE). Based on the widely recognized fact that oxidative stress is a major trigger of several physiological processes, this study was designed to establish the significance of vasodilatory cyclases and telomere length in HA physiology...
March 2018: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/29431475/increased-anxiety-and-anhedonia-in-female-rats-following-exposure-to-altitude
#18
Chandni Sheth, Hendrik Ombach, Paul Olson, Perry F Renshaw, Shami Kanekar
Sheth, Chandni, Hendrik Ombach, Paul Olson, Perry F. Renshaw, and Shami Kanekar. Increased anxiety and anhedonia in female rats following exposure to altitude. High Alt Med Biol. 19:81-90, 2018.-Anxiety disorders are chronic, highly prevalent conditions, often comorbid with depression. Both anxiety and depression form major risk factors for suicide. Living at altitude is associated with higher rates of depression and suicide, leading us to address whether anxiety disorders may also be amplified at altitude...
March 2018: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/29298124/inhaled-budesonide-does-not-affect-hypoxic-pulmonary-vasoconstriction-at-4559-meters-of-altitude
#19
Marc Moritz Berger, Franziska Macholz, Peter Schmidt, Sebastian Fried, Tabea Perz, Daniel Dankl, Josef Niebauer, Peter Bärtsch, Heimo Mairbäurl, Mahdi Sareban
Berger, Marc Moritz, Franziska Macholz, Peter Schmidt, Sebastian Fried, Tabea Perz, Daniel Dankl, Josef Niebauer, Peter Bärtsch, Heimo Mairbäurl, and Mahdi Sareban. Inhaled budesonide does not affect hypoxic pulmonary vasoconstriction at 4559 meters of altitude. High Alt Med Biol 19:52-59, 2018.-Oral intake of the corticosteroid dexamethasone has been shown to lower pulmonary artery pressure (PAP) and to prevent high-altitude pulmonary edema. This study tested whether inhalation of the corticosteroid budesonide attenuates PAP and right ventricular (RV) function after rapid ascent to 4559 m...
March 2018: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/29265914/the-physiology-of-paragliding-flight-at-moderate-and-extreme-altitudes
#20
Matt Wilkes, Martin J MacInnis, Lucy A Hawkes, Heather Massey, Clare Eglin, Michael J Tipton
Wilkes, Matt, Martin J. MacInnis, Lucy A. Hawkes, Heather Massey, Clare Eglin, and Michael J. Tipton. The physiology of paragliding flight at moderate and extreme altitudes. High Alt Med Biol 19:42-51, 2018.-Paragliding is a form of free flight, with extreme-altitude paragliding being an emerging discipline. We aimed to describe the physiological demands and the impact of environmental stressors of paragliding at moderate and extreme altitudes. We recorded oxygen consumption (VO2 ), heart rate (HR), respiratory frequency (fR), tidal volume (VT ), oxygen saturation, accelerometry (G), and altitude in 9...
March 2018: High Altitude Medicine & Biology
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