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High Altitude Medicine & Biology

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https://www.readbyqxmd.com/read/28910201/reentry-high-altitude-pulmonary-edema-in-the-himalayas
#1
Santosh Baniya, Christopher Holden, Buddha Basnyat
Baniya, Santosh, Christopher Holden, and Buddha Basnyat. Reentry high altitude pulmonary edema in the Himalayas. High Alt Med Biol. 16:000-000, 2017.-Reentry high altitude pulmonary edema (HAPE), a subset of HAPE, is a well recognized, life-threatening illness documented almost exclusively in the North and South Americans, who live at high altitude (>2500 m) and return to their homes after a brief sojourn of days to months at lower altitude. This phenomenon has not been reported in Sherpas or other people of Tibetan origin in Nepal or India...
September 14, 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28876128/influence-of-inhaled-amiloride-on-lung-fluid-clearance-in-response-to-normobaric-hypoxia-in-healthy-individuals
#2
Courtney M Wheatley, Sarah E Baker, Bryan J Taylor, Manda L Keller-Ross, Steven C Chase, Alex R Carlson, Robert J Wentz, Eric M Snyder, Bruce D Johnson
Wheatley, Courtney M., Sarah E. Baker, Bryan J. Taylor, Manda L. Keller-Ross, Steven C. Chase, Alex R. Carlson, Robert J. Wentz, Eric M. Snyder, and Bruce D. Johnson. Influence of inhaled amiloride on lung fluid clearance in response to normobaric hypoxia in healthy individuals. High Alt Med Biol 00:000-000, 2017. AIM: To investigate the role of epithelial sodium channels (ENaC) on lung fluid clearance in response to normobaric hypoxia, 20 healthy subjects were exposed to 15 hours of hypoxia (fraction of inspired oxygen [FiO2] = 12...
September 6, 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28846046/the-use-of-simulated-altitude-techniques-for-beneficial-cardiovascular-health-outcomes-in-nonathletic-sedentary-and-clinical-populations-a-literature-review
#3
Catherine A Lizamore, Michael J Hamlin
Lizamore, Catherine A., and Michael J. Hamlin. The use of simulated altitude techniques for beneficial cardiovascular health outcomes in nonathletic, sedentary, and clinical populations: A literature review. High Alt Med Biol 00:000-000, 2017. BACKGROUND: The reportedly beneficial improvements in an athlete's physical performance following altitude training may have merit for individuals struggling to meet physical activity guidelines. AIM: To review the effectiveness of simulated altitude training methodologies at improving cardiovascular health in sedentary and clinical cohorts...
August 28, 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28846044/red-maca-lepidium-meyenii-a-plant-from-the-peruvian-highlands-promotes-skin-wound-healing-at-sea-level-and-at-high-altitude-in-adult-male-mice
#4
Denisse Nuñez, Paola Olavegoya, Gustavo F Gonzales, Cynthia Gonzales-Castañeda
Nuñez, Denisse, Paola Olavegoya, Gustavo F. Gonzales, and Cynthia Gonzales-Castañeda. Red maca (Lepidium meyenii), a plant from the Peruvian highlands, promotes skin wound healing at sea level and at high altitude in adult male mice. High Alt Med Biol 00:000-000, 2015.-Wound healing consists of three simultaneous phases: inflammation, proliferation, and remodeling. Previous studies suggest that there is a delay in the healing process in high altitude, mainly due to alterations in the inflammatory phase. Maca (Lepidium meyenii) is a Peruvian plant with diverse biological properties, such as the ability to protect the skin from inflammatory lesions caused by ultraviolet radiation, as well as its antioxidant and immunomodulatory properties...
August 28, 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28816526/echocardiographic-assessment-of-right-ventricle-dimensions-and-function-after-exposure-to-extreme-altitude-is-an-expedition-to-8000%C3%A2-m-hazardous-for-right-ventricular-function
#5
Marta Kurdziel, Jarosław Wasilewski, Karolina Gierszewska, Anna Kazik, Gracjan Pytel, Jacek Wacławski, Adam Krajewski, Anna Kurek, Lech Poloński, Mariusz Gąsior
Kurdziel, Marta, Jarosław Wasilewski, Karolina Gierszewska, Anna Kazik, Gracjan Pytel, Jacek Wacławski, Adam Krajewski, Anna Kurek, Lech Poloński, and Mariusz Gąsior. Echocardiographic assessment of right ventricle dimensions and function after exposure to extreme altitude: Is an expedition to 8000 m hazardous for right ventricular function? High Alt Med Biol 00:000-000, 2017.-Although the right ventricle (RV) is under great hypoxic stress at altitude, still little is known what happens to the RV after descent...
August 17, 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28742397/morbidity-in-the-mountainous-province-of-kyrgyzstan-results-from-a-population-based-cross-sectional-study
#6
Nurlan Brimkulov, Louis Louton, Salima Sydykova, Denis Vinnikov, Farida Imanalieva
Brimkulov, Nurlan, Louis Louton, Salima Sydykova, Denis Vinnikov, and Farida Imanalieva. Morbidity in the mountainous Province of Kyrgyzstan: results from a population-based cross-sectional study. High Alt Med Biol 00:000-000, 2017.-The aim of this study was to identify the main causes of using primary care facilities in the mountainous Naryn Province of Kyrgyzstan to set resources allocation priorities. We collected data on all admissions to family doctors in three Family Medical Centers (FMCs) in Naryn Province: (1) the city of Naryn (2200 meters above sea level [MASL]); (2) the town of At-Bashy (3200 MASL); and the town of Kochkor (1800 MASL) by using an original questionnaire during one full week (5 days) in spring 2016...
July 25, 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28665150/association-between-plasma-n-acylethanolamides-and-high-hemoglobin-concentration-in-southern-peruvian-highlanders
#7
Dulce E Alarcón-Yaquetto, Lidia Caballero, Gustavo F Gonzales
Alarcón-Yaquetto, Dulce E., Lidia Caballero, and Gustavo F. Gonzales. Association between plasma N-acylethanolamides and high hemoglobin concentration in Southern Peruvian highlanders. High Alt Med Biol 00:000-000, 2017.-High-altitude (HA) hypoxia is a stressful condition endured by organisms through different mechanisms. Failing to adapt to chronic HA exposure leads to a disease called chronic mountain sickness (CMS) characterized by excessive erythrocytosis (hemoglobin [Hb] ≥19 g/dL for women and ≥21 g/dL for men)...
June 30, 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28876136/electron-microscopy-observation-of-human-pulmonary-ultrastructure-in-two-patients-with-high-altitude-pulmonary-edema
#8
Yunden Droma, Akane Kato, Takashi Ichiyama, Nobumitsu Kobayashi, Takayuki Honda, Takeshi Uehara, Masayuki Hanaoka
We examined the pulmonary ultrastructure in tissue from two patients with high-altitude pulmonary edema (HAPE) by electron microscopy. In one case, we found that neutrophils were trapped in pulmonary capillary lumen of alveolar-capillary wall and part of the cytoplasm of a neutrophil protruded and adhered to the capillary endothelium. There were several degranulated vacuoles in the cytoplasm of the neutrophil. The pulmonary capillary wall was deformed, thickened, and swollen and there was evidence of degeneration...
September 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28876129/relationship-between-occupational-physical-activity-and-subclinical-vascular-damage-in-moderate-altitude-dwellers
#9
Kristian Ujka, Rosa Maria Bruno, Luca Bastiani, Eva Bernardi, Paolo Sdringola, Nenad Dikic, Bikash Basyal, Sanjeeb Sundarshan Bhandari, Buddha Basnyat, Annalisa Cogo, Lorenza Pratali
Ujka, Kristian, Rosa Maria Bruno, Luca Bastiani, Eva Bernardi, Paolo Sdringola, Nenad Dikic, Bikash Basyal, Sanjeeb Sundarshan Bhandari, Buddha Basnyat, Annalisa Cogo, and Lorenza Pratali. Relationship between occupational physical activity and subclinical vascular damage in moderate-altitude dwellers. High Alt Med Biol. 18:249-257, 2017. BACKGROUND: Occupational physical activity (OPA) has been associated with increased cardiovascular (CV) events. The aim of this study was to investigate the association between OPA and markers of subclinical vascular damage among a moderate-altitude population living in the rural village of Chaurikharka (Nepal; 2600 m sea level)...
September 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28850251/systemic-hypoxia-increases-circulating-concentration-of-apelin-in-humans
#10
Ilkka Heinonen, Olli Vuolteenaho, Juha Koskenvuo, Olli Arjamaa, Mikko Nikinmaa
Heinonen, Ilkka, Olli Vuolteenaho, Juha Koskenvuo, Olli Arjamaa, and Mikko Nikinmaa. Systemic hypoxia increases circulating concentration of apelin in humans. High Alt Med Biol. 18:292-295, 2017. BACKGROUND: Apelin is a hormone that regulates cardiovascular function, and its concentration is increased by hypoxia based on cell culture and animal studies. As it remains unknown as to whether hypoxia could affect apelin levels in humans, we investigated whether breathing normobaric hypoxic gas mixture increases the circulating apelin concentration in healthy male subjects...
September 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28846035/high-altitude-pulmonary-edema-in-mountain-community-residents
#11
Christine Ebert-Santos
Ebert-Santos, Christine. High-altitude pulmonary edema in mountain community residents. High Alt Med Biol. 18:278-284, 2017.-High-altitude pulmonary edema (HAPE) affects lowlanders ascending quickly to elevations above 2440 m. Mountain resident children with no travel can sometimes develop HAPE as was observed over 30 years ago (Fasules et al., 1985). This is not well known and children instead are diagnosed as having pneumonia or asthma. In our clinic at 2800 m, we see children presenting with severe hypoxemia, clinical, and radiographic findings consistent with HAPE despite no recent travel...
September 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28846033/metabolic-alterations-of-qinghai-tibet-plateau-pikas-in-adaptation-to-high-altitude
#12
Xue-Feng Cao, Zhen-Zhong Bai, Lan Ma, Shuang Ma, Ri-Li Ge
Cao, Xue-Feng, Zhen-Zhong Bai, Lan Ma, Shuang Ma, and Ri-Li Ge. Metabolic alterations of Qinghai-Tibet plateau pikas in adaptation to high altitude. High Alt Med Biol. 18:219-225, 2017.-To determine specific metabolic alterations in the myocardium of plateau pikas (Ochotona curzoniae) and potential metabolic biomarkers involved in their adaptation to the high-altitude environment of the Qinghai-Tibet Plateau. Ten pikas were captured by traps in the Kekexili Reserve (4630 m a.s.l; n = 5) and at the foot of the Laji Mountain (2600 m a...
September 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28787190/blood-pressure-and-altitude-an-observational-cohort-study-of-hypertensive-and-nonhypertensive-himalayan-trekkers-in-nepal
#13
Linda E Keyes, Thomas Douglas Sallade, Charles Duke, Jennifer Starling, Alison Sheets, Sushil Pant, David S Young, David Twillman, Nirajan Regmi, Benoit Phelan, Purshotam Paudel, Matthew McElwee, Luke Mather, Devlin Cole, Theodore McConnell, Buddha Basnyat
Keyes, Linda E., Thomas Douglas Sallade, Charles Duke, Jennifer Starling, Alison Sheets, Sushil Pant, David S. Young, David Twillman, Nirajan Regmi, Benoit Phelan, Purshotam Paudel, Matthew McElwee, Luke Mather, Devlin Cole, Theodore McConnell, and Buddha Basnyat. Blood pressure and altitude: an observational cohort study of hypertensive and nonhypertensive Himalayan trekkers in Nepal. High Alt Med Biol. 18:267-277, 2017. OBJECTIVES: To determine how blood pressure (BP) changes with altitude in normotensive versus hypertensive trekkers...
September 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28753037/-direct-and-indirect-methods-to-detect-oxidative-stress-during-acute-or-chronic-high-altitude-exposure
#14
Simona Mrakic-Sposta, Alessandra Vezzoli, Sandro Malacrida, Marika Falla, Giacomo Strapazzon
No abstract text is available yet for this article.
September 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28704070/geographic-variation-in-mentally-unhealthy-days-air-pollution-and-altitude-perspectives
#15
Hoehun Ha
Ha, Hoehun. Geographic variation in mentally unhealthy days: air pollution and altitude perspectives. High Alt Med Biol. 18:258-266, 2017. BACKGROUND: Mental health incorporates our emotional, psychological, and social well-being and it is critical at each phase of life, from youth and preadulthood through adulthood. METHODS: We assessed the association between mentally unhealthy days (MUDs), air pollutant concentrations, and altitude on the basis of cross-county studies...
September 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28628341/observational-study-of-neural-respiratory-drive-during-sleep-at-high-altitude
#16
Joerg Steier, Nic Cade, Ben Walker, John Moxham, Caroline Jolley
Steier, Joerg, Nic Cade, Ben Walker, John Moxham, and Caroline Jolley. Observational study of neural respiratory drive during sleep at high altitude. High Alt Med Biol. 18:242-248, 2017. AIMS: Ventilation at altitude changes due to altered levels of pO2, pCO2 and the effect on blood pH. Nocturnal ventilation is particularly exposed to these changes. We hypothesized that an increasing neural respiratory drive (NRD) is associated with the severity of sleep-disordered breathing at altitude...
September 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28604118/practical-tips-for-working-as-an-expedition-doctor-on-high-altitude-expeditions
#17
Anne Brants, Tracee Metcalfe
Brants, Anne, and Tracee Metcalfe. Practical tips for working as an expedition doctor on high-altitude expeditions. High Alt Med Biol. 18:193-198, 2017.-With the explosion of adventure travel over the past decade, there has been a concurrent increase in mountaineering expeditions to extreme elevations, including many of the 8000-m peaks. This trend has created an increased demand for qualified expedition doctors to provide specialized medical advice and care to climbers and expedition staff. This review is intended to help physicians prepare for work on such expeditions...
September 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28581355/pathologizing-altitude-does-altitude-really-increase-sleep-disordered-breathing
#18
Santiago Ucrós Rodríguez
No abstract text is available yet for this article.
September 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28486037/role-of-arcuate-nucleus-in-the-regulation-of-feeding-behavior-in-the-process-of-altitude-acclimatization-in-rats
#19
Xiang-Wen Liu, Jie Yin, Qi-Sheng Ma, Chu-Chu Qi, Ji-Ying Mu, Lang Zhang, Li-Ping Gao, Yu-Hong Jing
Liu, Xiang-Wen, Jie Yin, Qi-Sheng Ma, Chu-Chu Qi, Ji-Ying Mu, Lang Zhang, Li-Ping Gao, and Yu-Hong Jing. Role of arcuate nucleus in the regulation of feeding behavior in the process of altitude acclimatization in rats. High Alt Med Biol. 18:234-241, 2017.-Highly efficient energy utilization and metabolic homeostasis maintenance rely on neuromodulation. Altitude exposure is known to stimulate neuroendocrine systems to respond to acute hypoxia and adaptive acclimatization. However, limited data on how the adaptive regulation of the arcuate nucleus performs in the process of altitude acclimatization are available...
September 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28485995/congenital-heart-disease-and-high-altitude-is-chronic-hypoxia-a-common-factor-in-intellectual-impairment
#20
Laxmi V Ghimire
No abstract text is available yet for this article.
September 2017: High Altitude Medicine & Biology
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