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HPB: the Official Journal of the International Hepato Pancreato Biliary Association

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https://www.readbyqxmd.com/read/29784604/research-gaps-and-unanswered-questions-in-gallbladder-cancer
#1
EDITORIAL
Kjetil Søreide, Ewen M Harrison, Stephen J Wigmore
No abstract text is available yet for this article.
May 18, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29779970/transarterial-chemoembolization-plus-iodine-125-implantation-for-hepatocellular-carcinoma-a-systematic-review-and-meta-analysis
#2
REVIEW
Ze-Xin Zhu, Xiao-Xue Wang, Ke-Fei Yuan, Ji-Wei Huang, Yong Zeng
BACKGROUND: Hepatocellular carcinoma (HCC) is the most common malignancy in liver. Transarterial chemoembolization (TACE) is recommended as an effective treatment in advanced HCC patients. Recent studies showed iodine-125 seed (a low-energy radionuclide) can provide long-term local control and increase survival for HCC patients. The aim of the study was to evaluate the outcome of TACE plus iodine-125 seed in comparison with TACE alone for HCC. METHODS: A comprehensive search of studies among PubMed, Embase, Cochrane Central Register of Controlled Trials, and Cochrane Database of Systematic Reviews was conducted with published date from the earliest to January 10th, 2018...
May 17, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29773356/a-web-based-overview-systematic-review-and-meta-analysis-of-pancreatic-anastomosis-techniques-following-pancreatoduodenectomy
#3
REVIEW
Lois A Daamen, F Jasmijn Smits, Marc G Besselink, Olivier R Busch, Inne H Borel Rinkes, Hjalmar C van Santvoort, I Quintus Molenaar
BACKGROUND: Many pancreatic anastomoses have been proposed to reduce the incidence of postoperative pancreatic fistula (POPF) after pancreatoduodenectomy, but a complete overview is lacking. This systematic review and meta-analysis aims to provide an online overview of all pancreatic anastomosis techniques and to evaluate the incidence of clinically relevant POPF in randomized controlled trials (RCTs). METHODS: A literature search was performed to December 2017...
May 14, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29759640/enhancer-of-zeste-homolog-2-ezh2-regulates-tumor-angiogenesis-and-predicts-recurrence-and-prognosis-of-intrahepatic-cholangiocarcinoma
#4
Shigeki Nakagawa, Hirohisa Okabe, Mayuko Ouchi, Ryuma Tokunaga, Naoki Umezaki, Takaaki Higashi, Takatoshi Kaida, Kota Arima, Yuki Kitano, Hideyuki Kuroki, Kosuke Mima, Hidetoshi Nitta, Katsunori Imai, Daisuke Hashimoto, Yo-Ichi Yamashita, Akira Chikamoto, Hideo Baba
BACKGROUND: Enhancer of zeste homolog 2 (EZH2) is the catalytic subunit of the polycomb repressive complex 2 (PRC2) and regulates tumor malignancy by gene silencing via histone methylation. In this study we investigate the role of EZH2 in angiogenesis of intrahepatic cholangiocarcinoma (ICC). METHODS: The influence of EZH2 on tumor angiogenesis was examined by bioinformatics analysis of a public database. We also assessed the correlation between EZH2 and vasohibin 1 (VASH1) expression in 47 patients with ICC by immunohistochemical (IHC) staining and in vitro gene silencing assays...
May 11, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29753633/does-mesenteric-venous-imaging-assessment-accurately-predict-pathologic-invasion-in-localized-pancreatic-ductal-adenocarcinoma
#5
Jesse Clanton, Stephen Oh, Stephen J Kaplan, Emily Johnson, Andrew Ross, Richard Kozarek, Adnan Alseidi, Thomas Biehl, Vincent J Picozzi, William S Helton, David Coy, Russell Dorer, Flavio G Rocha
BACKGROUND: Accurate prediction of mesenteric venous involvement in pancreatic ductal adenocarcinoma (PDAC) is necessary for adequate staging and treatment. METHODS: A retrospective cohort study was conducted in PDAC patients at a single institution. All patients with resected PDAC and staging CT and EUS between 2003 and 2014 were included and sub-divided into "upfront resected" and "neoadjuvant chemotherapy (NAC)" groups. Independent imaging re-review was correlated to venous resection and venous invasion...
May 9, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29706425/outcome-of-neoadjuvant-chemotherapy-in-locally-advanced-borderline-resectable-gallbladder-cancer-the-need-to-define-indications
#6
Vikram A Chaudhari, Vikas Ostwal, Shraddha Patkar, Arvind Sahu, Anup Toshniwal, Anant Ramaswamy, Nitin S Shetty, Shailesh V Shrikhande, Mahesh Goel
BACKGROUND: Studies evaluating neo-adjuvant chemotherapy (NACT) exclusively in gallbladder cancer (GBC) are few and there are no randomized trials on the subject. Locally advanced GBC and indications for NACT in GBC are not yet clearly defined. METHODS: We analysed 160 consecutive GBC patients who received NACT based on clinico-radiologic criteria suggesting high-risk disease (TMH Criteria) from January 2010 to February 2016. RESULTS: On initial assessment, 140 (87...
April 26, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29705346/pancreatoduodenectomy-with-colon-resection-for-pancreatic-cancer-a-systematic-review
#7
REVIEW
Leonardo Solaini, Thijs de Rooij, E Madelief Marsman, Wouter W Te Riele, Pieter J Tanis, Thomas M van Gulik, Dirk J Gouma, Neal H Bhayani, Thilo Hackert, Olivier R Busch, Marc G Besselink
BACKGROUND: Radical resection of advanced pancreatic cancer may occasionally require a simultaneous colon resection. The risks and benefits of this combined procedure are largely unknown. This systematic review aimed to assess short and long term outcome after pancreatoduodenectomy with colon resection (PD-colon) for pancreatic ductal adenocarcinoma (PDAC). METHODS: A systematic literature search was performed in PubMed, Embase, and the Cochrane Library for studies published between 1994 and 2017 concerning PD-colon for PDAC...
April 25, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29705345/does-blood-group-affect-survival-following-pancreatoduodenectomy-for-periampullary-malignancy
#8
Khalid Khalil, Sukhchain Bansal, Soofiyah Ayaani, James Hodson, For Tai Lam, Saboor Khan, Jawad Ahmad, John Isaac, Paolo Muiesan, Darius Mirza, Bobby Dasari, Ravi Marudanayagam, Robert P Sutcliffe, Gabriele Marangoni, Keith J Roberts
BACKGROUND: Blood group is reported to have an effect upon survival following pancreatoduodenectomy for pancreatic ductal adenocarcinoma. The effect of blood group is not known, however, among patients with other periampullary cancers. This study sought to review this. METHODS: Data were collected for a range of factors and survival outcomes from patients treated at two centres. Those with blood groups B and AB were excluded, due to small numbers. Patient survival was compared between patients with blood groups O and A using multivariable analysis which accounted for confounding factors...
April 25, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29705344/postoperative-complications-as-a-predictor-for-survival-after-liver-transplantation-proposition-of-a-prognostic-score
#9
Thomas R Daugaard, Hans-Christian Pommergaard, Andreas A Rostved, Allan Rasmussen
BACKGROUND: Liver transplantation is major surgery with a high risk of complications. Existing scoring systems for evaluating complications after surgery are not specific for liver transplantation. Nor are they designed to evaluate the relation to recipient survival or graft loss. We wished to uncover the relation between postoperative complications and one-year risk of death or retransplantation, and to develop a prognostic score for complications based on our findings. METHOD: The study was a retrospective cohort study including 253 adult liver recipients...
April 25, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29703649/index-versus-delayed-cholecystectomy-in-mild-gallstone-pancreatitis-results-of-a-randomized-controlled-trial
#10
Rozh Noel, Urban Arnelo, Lars Lundell, Folke Hammarqvist, Hanaz Jumaa, Lars Enochsson, Gabriel Sandblom
BACKGROUND: Delayed cholecystectomy is associated with increased risk of biliary events. The objectives of the study were to confirm the superiority of index cholecystectomy over delayed operation in mild gallstone pancreatitis. METHODS: Patients with mild gallstone pancreatitis were randomized into index-or delayed cholecystectomy (IC vs. DC). IC was performed within 48 h from randomization provided a stable or improved clinical condition. The primary outcome was gallstone-related events...
April 24, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29699859/clinical-significance-of-macroscopic-no-margin-hepatectomy-for-hepatocellular-carcinoma
#11
Seiji Oguro, Jiro Yoshimoto, Hiroshi Imamura, Yoichi Ishizaki, Seiji Kawasaki
BACKGROUND: Hepatectomy with a sufficient margin is often impossible for hepatocellular carcinomas that are close to the large intrahepatic vascular structures, and macroscopically complete resection along the tumor capsule is the only choice. The aim of this retrospective study was to evaluate the clinical significance of macroscopic no-margin hepatectomy (MNMH). METHODS: Among patients undergoing macroscopically curative resection for untreated hepatocellular carcinoma, outcomes were compared between patients undergoing MNMH (n = 87) and those undergoing hepatectomy with a macroscopic margin (n = 192)...
April 24, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29691125/perioperative-complications-and-the-cost-of-rescue-or-failure-to-rescue-in-hepato-pancreato-biliary-surgery
#12
Qinyu Chen, Eliza W Beal, Charles W Kimbrough, Fabio Bagante, Katiuscha Merath, Mary Dillhoff, Carl Schmidt, Susan White, Jordan Cloyd, Timothy M Pawlik
BACKGROUND: It is unclear how either the successful or failed rescue of hepato-pancreato-biliary (HPB) patients from complications impacts costs. METHODS: A retrospective cohort study of HPB surgical patients was performed using claims data from 2013 to 2015 in the Medicare Provider Analysis and Review (MEDPAR) database. Patient demographics, characteristics, outcomes and risk-adjusted Medicare payments were compared. RESULTS: 11,596 patients were identified...
April 21, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29691124/severe-acute-kidney-injury-following-major-liver-resection-without-portal-clamping-incidence-risk-factors-and-impact-on-short-term-outcomes
#13
Jonathan Garnier, Marion Faucher, Ugo Marchese, Hélène Meillat, Djamel Mokart, Jacques Ewald, Jean-Robert Delpero, Olivier Turrini
BACKGROUND: Acute kidney injury (AKI) following major hepatectomy (MH) remains inadequately investigated. This retrospective study aimed to assess the risk factors and prognostic value of AKI on short-term outcomes following MH without portal pedicle clamping. METHODS: From January 2014 through June 2017, 111 consecutive patients underwent MH without portal pedicle clamping, but with intraoperative low-crystalloid infusion. Kidney Disease Improving Global Outcomes stages II and III were classified as severe AKI...
April 21, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29678364/surgeons-assessment-versus-risk-models-for-predicting-complications-of-hepato-pancreato-biliary-surgery-hpb-risc-a-multicenter-prospective-cohort-study
#14
Morsal Samim, Timothy H Mungroop, Mohammed AbuHilal, Cas J Isfordink, Quintus I Molenaar, Marcel J van der Poel, Thomas A Armstrong, Arjun S Takhar, Neil W Pearce, John N Primrose, Scott Harris, Helena M Verkooijen, Thomas M van Gulik, Jeroen Hagendoorn, Olivier R Busch, Colin D Johnson, Marc G Besselink
BACKGROUND: Several studies advise the use of risk models when counseling patients for hepato-pancreato-biliary (HPB) surgery, but studies comparing these models to the surgeons' assessment are lacking. The aim of this study was to assess whether risk prediction models outperform surgeons' assessment for the risk of complications in HPB surgery. METHODS: This prospective study included adult patients scheduled for HPB surgery in three centers in the UK and the Netherlands...
April 17, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29661564/a-new-technique-for-hepatic-parenchymal-transection-using-an-articulating-bipolar-5-cm-radiofrequency-device-results-from-the-first-100-procedures
#15
Hideo Takahashi, Muhammet Akyuz, Erol Aksoy, Federico Aucejo, Cristiano Quintini, Charles Miller, John Fung, Eren Berber
BACKGROUND: Parenchymal transection(PT) still remains a challenge in liver resection. The outcomes of the first experience of a novel vessel-sealer for hepatic transection were assessed. METHODS: A bipolar articulating vessel-sealer (Caiman® , Aesculap Inc., Center Valley, PA) was used in 100 liver resections through both open (OLR) and laparoscopic (LLR) approaches. All data were prospectively collected into an IRB-approved department database, and clinical, surgical and perioperative parameters were analyzed...
April 13, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29650299/reporting-of-complications-after-laparoscopic-cholecystectomy-a-systematic-review
#16
REVIEW
Harry C Alexander, Adam S Bartlett, Cameron I Wells, Jacqueline A Hannam, Matthew R Moore, Garth H Poole, Alan F Merry
BACKGROUND: Consistent measurement and reporting of outcomes, including adequately defined complications, is important for the evaluation of surgical care and the appraisal of new surgical techniques. The range of complications reported after LC has not been evaluated. This study aimed to identify the range of complications currently reported for laparoscopic cholecystectomy (LC), and the adequacy of their definitions. METHODS: MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials were searched for prospective studies reporting clinical outcomes of LC, between 2013 and 2016...
April 9, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29625899/safety-and-feasibility-of-elective-liver-resection-in-adult-jehovah-s-witnesses-the-henri-mondor-hospital-experience
#17
Chetana Lim, Chady Salloum, Francesco Esposito, Alexandros Giakoustidis, Toufic Moussallem, Michael Osseis, Eylon Lahat, Marc Lanteri-Minet, Daniel Azoulay
BACKGROUND: Elective liver resection (LR) in Jehovah's Witness (JW) patients, for whom transfusion is not an option, involves complex ethical and medical issues and surgical difficulties. METHODS: Consecutive data from a LR program for liver tumors in JWs performed between 2014 and 2017 were retrospectively reviewed. A systematic review of the literature with a pooled analysis was performed. RESULTS: Ten patients were included (median age = 61 years)...
April 3, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29622402/vascular-invasion-and-survival-after-liver-transplantation-for-hepatocellular-carcinoma-a-study-from-the-european-liver-transplant-registry
#18
Hans-Christian Pommergaard, Andreas A Rostved, René Adam, Lau C Thygesen, Mauro Salizzoni, Miguel A Gómez Bravo, Daniel Cherqui, Franco Filipponi, Karim Boudjema, Vincenzo Mazzaferro, Olivier Soubrane, Juan C García-Valdecasas, Joan F Prous, Antonio D Pinna, John O'Grady, Vincent Karam, Christophe Duvoux, Allan Rasmussen
BACKGROUND: Studies suggest that vascular invasion may be a superior prognostic marker compared with traditional selection criteria, e.g. Milan criteria. This study aimed to investigate the prognostic value of micro and macrovascular invasion in a large database material. METHODS: Patients liver transplanted for HCC and cirrhosis registered in the European Liver Transplant Registry (ELTR) database were included. The association between the Milan criteria, Up-to-seven criteria and vascular invasion with overall survival and HCC specific survival was investigated with univariate and multivariate Cox regression analyses...
April 2, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29615370/hepatectomy-with-or-without-the-thoraco-abdominal-approach-impact-on-perioperative-outcome
#19
Matteo Donadon, Antonio Mimmo, Davide Cosola, Alfonso Terrone, Fabio Procopio, Daniele Del Fabbro, Matteo Cimino, Luca Viganò, Guido Torzilli
BACKGROUND: Hepatectomy using the thoraco-abdominal approach (TAA) compared to the abdominal approach (AA) remains under debate. This study assessed the perioperative outcomes of patients operated with or without TAA. METHODS: 1:1 propensity score-matched analysis was applied in 744 patients operated between 2007 and 2013, identifying 246 patients who underwent hepatectomy with TAA compared to 246 patients with AA. These groups were matched for demographics, liver disease, comorbidity, tumor features, and extent of resection...
March 31, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29602557/colicky-pain-and-related-complications-after-cholecystectomy-for-mild-gallstone-pancreatitis
#20
David W da Costa, Nicolien J Schepers, Stefan A Bouwense, Bob A Hollemans, Eva Doorakkers, Djamila Boerma, Camiel Rosman, Cees H Dejong, Marcel B W Spanier, Hjalmar C van Santvoort, Hein G Gooszen, Marc G Besselink
BACKGROUND: Same-admission cholecystectomy is advised after gallstone pancreatitis to prevent recurrent pancreatitis, colicky pain and other complications, but data on the incidence of symptoms and complications after cholecystectomy are lacking. METHODS: This was a prospective cohort study during the previously published randomized controlled PONCHO trial on timing of cholecystectomy after mild gallstone pancreatitis. Data on healthcare consumption and questionnaires focusing on colicky pain and biliary complications were obtained during 6 months after cholecystectomy...
March 27, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
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