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HPB: the Official Journal of the International Hepato Pancreato Biliary Association

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https://www.readbyqxmd.com/read/30401520/18f-fdg-pet-ct-predicts-microvascular-invasion-and-early-recurrence-after-liver-resection-for-hepatocellular-carcinoma-a-prospective-observational-study
#1
Chetana Lim, Chady Salloum, Julia Chalaye, Eylon Lahat, Charlotte E Costentin, Michael Osseis, Emmanuel Itti, Cyrille Feray, Daniel Azoulay
BACKGROUND: This study assessed the prognostic value of 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) in the prediction of MVI and early recurrence following resection. METHOD: This prospective study (ClinicalTrials.gov ID: NCT02145013) included 78 consecutive HCC patients who underwent 18F-FDG PET/CT before curative-intent resection from 2014 to 2017. Prognostic factors available before surgery for predicting MVI and early recurrence (≤2 years) were identified by univariate and multivariate analyses...
November 3, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/30401519/impact-of-indocyanine-green-fluorescence-imaging-on-distal-pancreatectomy-with-celiac-axis-resection-combined-with-reconstruction-of-the-left-gastric-artery
#2
Atsushi Oba, Yosuke Inoue, Takafumi Sato, Yoshihiro Ono, Yoshihiro Mise, Hiromichi Ito, Takeaki Ishizawa, Yu Takahashi, Akio Saiura
BACKGROUND: We previously reported the usefulness of distal pancreatectomy with celiac axis resection (DP-CAR) with left gastric artery (LGA) reconstruction to prevent ischemic gastropathy. To evaluate the reconstruction quality, we performed intraoperative angiography with indocyanine green (ICG)-fluorescence imaging. METHODS: 21 consecutive patients planned for DP-CAR with LGA reconstruction were enrolled in this prospective, exploratory single-arm study from 2014 to 2017...
November 3, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/30391219/a-nationwide-cohort-study-of-resection-rates-and-short-term-outcomes-in-open-and-laparoscopic-distal-pancreatectomy
#3
Kjetil Søreide, Frank Olsen, Linn S Nymo, Dyre Kleive, Kristoffer Lassen
BACKGROUND: Distal pancreatectomy (DP) is increasingly done by laparoscopy but data from routine practise are scarce. We describe practise in a national cohort. METHODS: Data from the Norwegian Patient Register of all patients undergoing DP from 2012 to 2016. National resection rates were analysed. Short-term outcomes include length of stay, reoperation, readmissions and 90-day mortality. Risk is reported as odds ratio (OR) with 95% confidence interval (c.i.). RESULTS: Of 554 procedures, 327 (59%) were laparoscopic...
October 31, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/30391218/multicenter-validation-of-a-score-to-predict-prognosis-after-the-development-of-hcc-recurrence-following-liver-transplantation
#4
Nicolás Goldaracena, Neil Mehta, Irene Scalera, Carlo Sposito, Eshetu G Atenafu, Francis Y Yao, Paolo Muiesan, Vincenzo Mazzaferro, Gonzalo Sapisochin
BACKGROUND: HCC recurrence after LT impacts negatively on survival. A recent study detected late recurrence (≥12 months), alpha-fetoprotein (AFP) <100 ng/mL at recurrence and being amenable for curative-intent treatments as good prognostic factors. With these variables a prognostic score was proposed. The objective of this study was to validate the prognostic score for hepatocellular carcinoma (HCC) recurrence following liver transplantation (LT). METHODS: Data from the University of California, San Francisco, the University Hospital of Birmingham and Instituto Nazionale dei Tumori, Milan including patients with HCC recurrence after LT were analyzed...
October 31, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/30389432/conditional-survival-in-patients-with-spontaneous-tumor-rupture-of-hepatocellular-carcinoma-after-partial-hepatectomy-a-propensity-score-matching-analysis
#5
Qian Zhu, Guoliang Qiao, Chang Xu, Xiaojin Yu, Jing Zhao, Zeqian Yu, Minjie Hu, Yang Yang, Lishan Wang, Miao Lu, Fangfang Hu, Zhangjun Cheng, Jiahua Zhou
BACKGROUND: Spontaneous tumor rupture (STR) of hepatocellular carcinoma (HCC) is a life-threatening condition. This study investigates the influences of STR on the observed survival and conditional survival of patients received hepatectomy. METHODS: A retrospective cohort of patients who underwent hepatectomy from 2009 to 2013 was divided into tumor rupture group and non-rupture group. Propensity score matching (PSM) was used for comparison of the observed survival and conditional survival probabilities between these two groups...
October 30, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/30385051/urinary-neutrophil-gelatinase-associated-lipocalins-ngals-predict-acute-kidney-injury-post-liver-transplant
#6
Francis P Robertson, Arthur C Yeung, Victoria Male, Suehana Rahman, Susan Mallett, Barry J Fuller, Brian R Davidson
BACKGROUND: Acute Kidney Injury, a common complication of liver transplant, is associated with a significant increase in the risk of morbidity, mortality and graft loss. Current diagnostic criteria leaves a delay in diagnosis allowing further potential irreversible damage. Early biomarkers of renal injury are of clinical importance and Neutrophil Gelatinase Associated Lipocalins (NGALs) and Syndecan-1 were investigated. METHODS: AKI was defined according to the Acute Kidney Injury Network criteria...
October 30, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/30377050/density-and-enhancement-of-the-pancreatic-tail-on-computer-tomography-predicts-acinar-score-and-pancreatic-fistula-after-pancreatoduodenectomy
#7
Christopher B Nahm, Isaac Lui, Catherine S Naidoo, Lucian Roseverne, Saeed Alzaabi, Richard Maher, Georgina Mann, Steven Blome, Anthony J Gill, Jaswinder S Samra, Anubhav Mittal
BACKGROUND: Acinar score calculated at the pancreatic resection margin is associated with postoperative pancreatic fistula (POPF) after pancreatoduodenectomy (PD). The present study evaluates the association between (i) computed tomography (CT) density of the pancreas and the acinar score of the pancreatic resection margin, and (ii) CT density of the pancreas and POPF after PD. METHODS: Consecutive patients who underwent PD were included for analysis. CT densities of the pancreatic head, neck, body and tail were measured in non-contrast (NC), arterial (ART) and portal venous (PV) phases...
October 27, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/30366884/limited-role-of-chromogranin-a-as-clinical-biomarker-for-pancreatic-neuroendocrine-tumors
#8
Alessandra Pulvirenti, Deepthi Rao, Caitlin A Mcintyre, Mithat Gonen, Laura H Tang, David S Klimstra, Martin Fleisher, Lakshmi V Ramanathan, Diane Reidy-Lagunes, Peter J Allen
BACKGROUND: Serum Chromogranin A (CgA) is widely used as a biomarker for pancreatic neuroendocrine tumors (PanNETs). The aim of this study was to investigate the value of CgA as a diagnostic and prognostic marker for well-differentiated PanNETs. METHODS: Patients with well-differentiated PanNET and a baseline CgA measurement, between 2011 and 2016 were reviewed. The diagnostic value was determined by comparing CgA values from patients with PanNETs to those with other pancreatic neoplasms and healthy controls...
October 23, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/30366883/scintigraphic-liver-function-and-transient-elastography-in-the-assessment-of-patients-with-resectable-hepatocellular-carcinoma
#9
Fadi Rassam, Pim B Olthof, Bart R Takkenberg, Ulrich Beuers, Heinz-Josef Klümpen, Roelof J Bennink, Krijn P van Lienden, Marc G Besselink, Olivier R Busch, Joanne Verheij, Thomas M van Gulik
BACKGROUND: Hepatobiliary scintigraphy (HBS) is used to quantify total and regional liver function. Transient elastography (TE) provides a non-invasive alternative to percutaneous biopsy to assess liver fibrosis and cirrhosis. This study aims to determine the correlation between HBS and histopathology of liver parenchyma, and to compare these with TE in patients with resectable hepatocellular carcinoma (HCC). METHODS: Patients who underwent surgery for HCC between 2000 and 2016 after preoperative HBS were included...
October 23, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/30366882/can-high-volume-teams-of-anesthesiologists-and-surgeons-decrease-perioperative-costs-for-pancreatic-surgery
#10
Abhineet Uppal, Brooke Vuong, Ahmed Dehal, Stacey L Stern, Juan Mejia, Roshanthi Weerasinghe, Vandana Kapoor, Evan Ong, Paul D Hansen, Anton J Bilchik
BACKGROUND: Pancreatic surgery outcomes are associated with surgeon and center experience. Anesthesiologists as potential value drivers for pancreatic surgery have not been explored. We sought to evaluate whether anesthesiologists impact perioperative costs for pancreatic surgery. METHODS: Within an integrated health care system, 796 pancreatic surgeries (526 PDs and 270 DPs) were performed from January 2014 to June 2017. Mean direct operative and anesthesia costs driven by anesthesiologists (operating room (OR) time, anesthesia billing and anesthesia procedures) were determined for each case...
October 23, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/30366881/adjuvant-chemotherapy-is-associated-with-improved-postoperative-survival-in-specific-subtypes-of-invasive-intraductal-papillary-mucinous-neoplasms-ipmn-of-the-pancreas-it-is-time-for-randomized-controlled-data
#11
Giovanni Marchegiani, Stefano Andrianello, Chiara Dal Borgo, Erica Secchettin, Davide Melisi, Giuseppe Malleo, Claudio Bassi, Roberto Salvia
BACKGROUND: Very little is known about adjuvant chemotherapy for invasive Intraductal Papillary Mucinous Neoplasms (IPMNs) of the pancreas. The aim was to assess whether adjuvant chemotherapy affects survival. METHODS: Retrospective evaluation of invasive IPMNs. Patients treated with surgery alone or followed by adjuvant chemotherapy were compared in terms of survival. RESULTS: A total of 102 invasive IPMNs were analyzed. Median follow-up was 72 (5-318) months and 18...
October 23, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/30361110/cyst-location-and-presence-of-high-grade-dysplasia-or-invasive-cancer-in-intraductal-papillary-mucinous-neoplasms-of-the-pancreas-a-seven-institution-study-from-the-central-pancreas-consortium
#12
Stephanie Kerlakian, Vikrom K Dhar, Daniel E Abbott, David A Kooby, Nipun B Merchant, Hong J Kim, Robert C Martin, Charles R Scoggins, David J Bentrem, Sharon M Weber, Shishir K Maithel, Syed A Ahmad, Sameer H Patel
BACKGROUND: Traditionally, intraductal papillary mucinous neoplasms (IPMNs) of the pancreas with "high risk stigmata" (HRS) or "worrisome features" (WF) are referred for resection. We aim to assess if IPMN location is predictive of harboring either high grade dysplasia (HGD) or invasive cancer (IC). METHODS: Patients undergoing resection for IPMN from seven institutions between 2000 and 2015 (n = 275) were analyzed. HRS and WF were defined by the 2012 Fukuoka international consensus guidelines...
October 23, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/30361112/standardization-of-operative-technique-in-minimally-invasive-right-hepatectomy-improving-cost-value-relationship-through-value-stream-mapping-in-hepatobiliary-surgery
#13
Mohammad R Jajja, Daniel Maxwell, Salila S Hashmi, Rebecca S Meltzer, Edward Lin, John F Sweeney, Juan M Sarmiento
BACKGROUND: With current emphasis on improving cost-quality relationship in medicine, it is imperative to evaluate cost-value relationships for surgical procedures. Previously the authors demonstrated comparable clinical outcomes for minimally invasive right hepatectomy (MIRH) and open right hepatectomy (ORH). MIRH had significantly higher intraoperative cost, though overall costs were similar. METHODS: MIRH was decoded into its component critical steps using value stream mapping, analyzing each associated cost...
October 22, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/30361111/developing-and-validating-a-pre-operative-risk-score-to-predict-post-hepatectomy-liver-failure
#14
Bobby V M Dasari, James Hodson, Keith J Roberts, Robert P Sutcliffe, Ravi Marudanayagam, Darius F Mirza, John Isaac, Paolo Muiesan
BACKGROUND: Post hepatectomy liver failure (PHLF) is a serious complication in patients undergoing liver resection. This study hypothesized that a new pre-operative risk score developed through statistical modeling to predict PHLF could be used to stratify patients at higher risk of PHLF. METHODS: Patients who underwent hepatectomy between 2008 and 2016 were included in the derivation and validation cohorts. A multivariable binary logistic regression model was performed to identify predictors of PHLF, and a prognostic score was derived...
October 22, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/30352736/calculus-left-in-remnant-gallbladder-cause-long-term-complications-in-patients-undergoing-subtotal-cholecystectomy
#15
Atsushi Kohga, Kenji Suzuki, Takuya Okumura, Kimihiro Yamashita, Jun Isogaki, Akihiro Kawabe, Taizo Kimura
BACKGROUND: There have been only a few reports that describe the long-term outcomes of Subtotal cholecystectomy (SC). METHODS: A total of 59 patients underwent "reconstituting" SC at our hospital between January 2005 and July 2017. In the 59 patients, risk factors for long-term complications were analyzed. In addition, in the patients with acute cholecystitis (AC), perioperative and long-term clinical factors were compared for patients who underwent SC (n = 48) and those who underwent total cholecystectomy (n = 378)...
October 20, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/30342833/does-liver-cirrhosis-have-an-impact-on-the-results-of-different-hepatic-inflow-occlusion-methods-in-laparoscopic-liver-resection-a-propensity-score-analysis
#16
Xiang Lan, Hongyu Li, Fei Liu, Bo Li, Yonggang Wei, Hua Zhang, Hongwei Xu
BACKGROUND: Few studies have analyzed the impact of liver cirrhosis on different hepatic inflow occlusion methods in laparoscopic liver resection (LLR). Intermittent Pringle (IP) was compared to continuous hemihepatic vascular inflow occlusion (CHVIO) in LLR in patients with or without cirrhosis. METHODS: Patients who underwent LLR at the West China Hospital of Sichuan University form January 2015 to October 2017 were grouped according to occlusion methods and severity of cirrhosis...
October 18, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/30337170/reply-to-the-outcomes-of-central-hepatectomy-versus-extended-hepatectomy-a-systematic-review-and-meta-analysis
#17
LETTER
Ian Jun Yan Wee
No abstract text is available yet for this article.
October 15, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/30322713/renal-outcomes-following-left-renal-vein-harvest-for-venous-reconstruction-during-pancreas-and-liver-surgery
#18
Benjamin P T Loveday, Martin J Dib, Sangita Sequeira, Nouf Alotaiby, Robin Visser, Andrew S Barbas, Alice C Wei, Sean P Cleary, Carol-Anne Moulton, Steven Gallinger, Paul D Greig, Ian D McGilvray
BACKGROUND: The left renal vein (LRV) may be used for venous reconstruction during hepato-pancreato-biliary (HPB) surgery, although concerns exist about compromising renal function. This study aimed to determine renal outcomes following LRV harvest during HPB resections. METHODS: Circumferential PV/SMV resections from 2008 to 2014 were included within two groups (LRV harvest, Control). Absolute and change in Creatinine (Cr) and estimated GFR (eGFR), and rates of acute kidney injury (AKI) and chronic kidney disease (CKD), were compared...
October 12, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/30316625/monitoring-quality-of-care-for-patients-with-pancreatic-cancer-a-modified-delphi-consensus
#19
Ashika D Maharaj, Liane Ioannou, Daniel Croagh, John Zalcberg, Rachel E Neale, David Goldstein, Neil Merrett, James G Kench, Kate White, Charles H C Pilgrim, Lorraine Chantrill, Peter Cosman, Andrew Kneebone, Lara Lipton, Mehrdad Nikfarjam, Jennifer Philip, Charbel Sandroussi, Peter Tagkalidis, Richard Chye, Koroush S Haghighi, Jaswinder Samra, Sue M Evans
BACKGROUND: Best practise care optimises survival and quality of life in patients with pancreatic cancer (PC), but there is evidence of variability in management and suboptimal care for some patients. Monitoring practise is necessary to underpin improvement initiatives. We aimed to develop a core set of quality indicators that measure quality of care across the disease trajectory. METHODS: A modified, three-round Delphi survey was performed among experts with wide experience in PC care across three states in Australia...
October 10, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/30314713/hemodynamic-changes-in-alpps-influence-liver-regeneration-and-function-results-from-a-prospective-study
#20
Federico Tomassini, Yves D'Asseler, Mariano C Giglio, Clarisse Lecluyse, Bieke Lambert, Mauricio Sainz-Barriga, Jo Van Dorpe, Anne Hoorens, Karen Geboes, Roberto I Troisi
BACKGROUND: Excessive increase of portal flow and pressure following extended hepatectomy have been associated to insufficient growth or function of the future liver remnant (FLR), with the risk of post-hepatectomy liver failure (PHLF). We prospectively assess the influence of liver hemodynamics on FLR regeneration and function in Associating Liver Partition and Portal vein ligation for Staged hepatectomy (ALPPS). METHODS: Twenty-three patients underwent ALPPS; liver hemodynamics were assessed throughout the procedures...
October 9, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
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