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HPB: the Official Journal of the International Hepato Pancreato Biliary Association

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https://www.readbyqxmd.com/read/28734693/a-systemic-review-and-meta-analysis-comparing-the-prognosis-of-multicentric-occurrence-and-vs-intrahepatic-metastasis-in-patients-with-recurrent-hepatocellular-carcinoma-after-hepatectomy
#1
Sheng-Lan Yang, Ying-Ying Luo, Min Chen, Yan-Ping Zhou, Fu-Rong Lu, Dan-Fang Deng, Yan-Ran Wu
BACKGROUND: The aim of this meta-analysis was to evaluate the prognosis of patients with different types of hepatocellular cancer (HCC) recurrence following hepatectomy. Specifically, it evaluated overall survival and disease-free survival in HCC patients with multicentric occurrence (MO) or intrahepatic metastasis (IM). METHODS: Medline, Cochrane, EMBASE, and Google Scholar were searched until August 22, 2016 using the following search terms: hepatocellular carcinoma, multicentric occurrence, intrahepatic metastasis, early recurrence, and late recurrence...
July 19, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28728891/impact-of-adjuvant-chemotherapy-on-survival-in-patients-with-intrahepatic-cholangiocarcinoma-a-multi-institutional-analysis
#2
Bradley N Reames, Fabio Bagante, Aslam Ejaz, Gaya Spolverato, Andrea Ruzzenente, Matthew Weiss, Sorin Alexandrescu, Hugo P Marques, Luca Aldrighetti, Shishir K Maithel, Carlo Pulitano, Todd W Bauer, Feng Shen, George A Poultsides, Oliver Soubrane, Guillaume Martel, Bas G Koerkamp, Alfredo Guglielmi, Endo Itaru, Timothy M Pawlik
BACKGROUND: The benefit of adjuvant chemotherapy for resected intrahepatic cholangiocarcinoma (ICC) is unclear. The aim of the current study was to investigate the impact of adjuvant chemotherapy on survival among patients undergoing resection of ICC using a multi-institutional database. METHODS: 1154 ICC patients undergoing curative-intent hepatectomy between 1990 and 2015 were identified from 14 institutions. Cox proportional hazard modeling was used to determine the impact of adjuvant chemotherapy on overall survival (OS)...
July 17, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28728890/clinical-influence-of-preoperative-factor-xiii-activity-in-patients-undergoing-pancreatoduodenectomy
#3
Nobuyuki Watanabe, Yukihiro Yokoyama, Tomoki Ebata, Gen Sugawara, Tsuyoshi Igami, Takashi Mizuno, Junpei Yamaguchi, Masato Nagino
BACKGROUND: The influence of decreased factor XIII (FXIII) activity on perioperative bleeding has been reported in some surgical procedures. The purposes of this study were to investigate the perioperative dynamics of FXIII in patients undergoing pancreatoduodenectomy and to clarify the effects of low preoperative FXIII activity on intraoperative bleeding and postoperative complications. METHODS: Total of 43 patients who underwent a pancreatoduodenectomy were enrolled...
July 17, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28716509/assessing-the-value-of-endoscopic-ultrasound-in-predicting-symptom-severity-and-long-term-clinical-course-in-chronic-pancreatitis
#4
Neal Bhutiani, John S Richey, Amber N Brown, Joshua Tierney, Stephen A McClave, Michael H Bahr, Gary C Vitale
BACKGROUND: To date, no studies have evaluated the correlation between number of endoscopic ultrasound (EUS) criteria met for chronic pancreatitis (CP) and symptom severity over the course of the disease. This study assessed the relationship between number of EUS-based diagnostic criteria for CP and CP severity over time. METHODS: A University of Louisville database was queried for patients undergoing EUS due to concern for chronic pancreatitis between 2005 and 2016...
July 15, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28716508/routine-intraoperative-cholangiography-during-cholecystectomy-is-a-cost-effective-approach-when-analysing-the-cost-of-iatrogenic-bile-duct-injuries
#5
Jenny M L Rystedt, Bobby Tingstedt, Fredrik Montgomery, Agneta K Montgomery
BACKGROUND: The total cost of bile duct injuries (BDIs) in an unselected national cohort of patients undergoing cholecystectomy are unknown. The aim was to evaluate costs associated with treatment of cholecystectomy-related BDIs and to calculate cost effectiveness of routine vs. on-demand intraoperative cholangiography (IOC). METHODS: Data from Swedish patients suffering a BDI during a 5 year period were analysed. Questionnaires to investigate loss-of-production and health status (EQ-5D) were distributed to patients who suffered a BDI during cholecystectomy and who underwent uneventful cholecystectomy (matched control group)...
July 14, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28711377/pancreas-exocrine-replacement-therapy-is-associated-with-increased-survival-following-pancreatoduodenectomy-for-periampullary-malignancy
#6
Keith J Roberts, Harald Schrem, James Hodson, Roberta Angelico, Bobby V M Dasari, Chris A Coldham, Ravi Marudanayagam, Robert P Sutcliffe, Paolo Muiesan, John Isaac, Darius F Mirza
BACKGROUND: Although many patients undergoing pancreatoduodenectomy (PD) for cancer have pancreatic exocrine insufficiency, pancreatic enzyme replacement therapy (PERT) is not routinely used, and effects upon post-operative survival are unclear. METHODS: This review of patients undergoing PD for periampullary malignancy sought to test for an association between PERT and overall survival, with post-hoc subgroup analysis performed after stratifying patients by the year of surgery, pancreatic duct width and tumour type...
July 12, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28709725/reply-to-erridge-et%C3%A2-al-re-gavriilidis-et%C3%A2-al-survival-following-redo-hepatectomy-vs-radiofrequency-ablation-for-recurrent-hepatocellular-carcinoma-a-systematic-review-and-meta-analysis
#7
LETTER
Paschalis Gavriilidis, Alan Askari, Daniel Azoulay
No abstract text is available yet for this article.
July 11, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28698017/stepwise-introduction-of-laparoscopic-liver-surgery-validation-of-guideline-recommendations
#8
Marcel J van der Poel, Floor Huisman, Olivier R Busch, Mohammad Abu Hilal, Thomas M van Gulik, Pieter J Tanis, Marc G Besselink
BACKGROUND: Uncontrolled introduction of laparoscopic liver surgery (LLS) could compromise postoperative outcomes. A stepwise introduction of LLS combined with structured training is advised. This study aimed to evaluate the impact of such a stepwise introduction. METHODS: A retrospective, single-center case series assessing short term outcomes of all consecutive LLS in the period November 2006-January 2017. The technique was implemented in a stepwise fashion. To evaluate the impact of this stepwise approach combined with structured training, outcomes of LLS before and after a laparoscopic HPB fellowship were compared...
July 8, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28693979/the-predictive-value-of-c-reactive-protein-crp-in-acute-pancreatitis-is-interval-change-in-crp-an-additional-indicator-of-severity
#9
Aaron D Stirling, Neil R Moran, Michael E Kelly, Paul F Ridgway, Kevin C Conlon
BACKGROUND: Using revised Atlanta classification defined outcomes, we compare absolute values in C-reactive protein (CRP), with interval changes in CRP, for severity stratification in acute pancreatitis (AP). METHODS: A retrospective study of all first incidence AP was conducted over a 5-year period. Interval change in CRP values from admission to day 1, 2 and 3 was compared against the absolute values. Receiver-operator characteristic (ROC) curve and likelihood ratios (LRs) were used to compare ability to predict severe and mild disease...
July 8, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28693978/pyogenic-liver-abscesses-a-contemporary-analysis-of-management-strategies-at-a-tertiary-institution
#10
Kyle Rismiller, John Haaga, Christopher Siegel, John B Ammori
BACKGROUND: Despite equivocal evidence, non-surgical management for pyogenic liver abscess (PLA) has become the standard of care at most institutions with surgery relegated to salvage therapy for those who fail less invasive means. The aim of this study was to describe the outcomes of a step-up approach to PLA management. METHODS: A retrospective chart review was conducted at a single institution for patients diagnosed with PLA over a 10-year period. Demographic, radiologic, microbiological, treatment, and outcomes data were collected and analyzed...
July 8, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28687148/-99m-tc-mebrofenin-hepatobiliary-scintigraphy-predicts-liver-failure-following-major-liver-resection-for-perihilar-cholangiocarcinoma
#11
Pim B Olthof, Robert J S Coelen, Roelof J Bennink, Michal Heger, Meng F Lam, Marc G Besselink, Olivier R Busch, Krijn P van Lienden, Thomas M van Gulik
BACKGROUND: Posthepatectomy liver failure (PHLF) is a threatening complication after liver surgery, especially in perihilar cholangiocarcinoma (PHC). This study aimed to assess the value of preoperative assessment of liver function using (99m)Tc-mebrofenin hepatobiliary scintigraphy (HBS) to predict PHLF in comparison with liver volume in PHC patients. METHODS: All patients who underwent resection of suspected PHC in a single center between 2000 and 2015 were included in the analysis...
July 4, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28687147/radiofrequency-ablation-compared-to-surgical-resection-for-curative-treatment-of-patients-with-colorectal-liver-metastases-a-meta-analysis
#12
REVIEW
Martinus J van Amerongen, Sjoerd F M Jenniskens, Peter B van den Boezem, Jurgen J Fütterer, Johannes H W de Wilt
BACKGROUND: Hepatic resection and ablative treatments, such as RFA are available treatment options for liver tumors. Advantages and disadvantages of these treatment options in patients with colorectal liver metastases need further evaluation. The purpose of this study was to systematically evaluate the role of radiofrequency ablation (RFA) compared to surgery in the curative treatment of patients with colorectal liver metastases (CRLM). METHODS: A systematic search was performed from MEDLINE, EMBASE and the Cochrane Library for studies directly comparing RFA with resection for CRLM, after which variables were evaluated...
July 4, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28684194/adjuvant-chemotherapy-for-resected-biliary-tract-cancers-a-systematic-review-and-meta-analysis
#13
REVIEW
Michele Ghidini, Gianluca Tomasello, Andrea Botticelli, Sandro Barni, Giampietro Zabbialini, Silvia Seghezzi, Rodolfo Passalacqua, Chiara Braconi, Fausto Petrelli
INTRODUCTION: The use of adjuvant treatment (AT) in resected biliary tract cancers (BTC) is still controversial. No efficacy comparison has been performed between chemotherapy (CT) and chemoradiotherapy (CTRT). A systematic review of the available evidence regarding adjuvant chemotherapy (AC) in resected BTC was performed. METHODS: PubMed, EMBASE, Web of Science, SCOPUS and The Cochrane Library databases were searched for relevant articles published. Only studies including at least 50 patients affected by tumors of gallbladder, intrahepatic, perihilar, and distal bile ducts were considered...
July 3, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28651898/remote-ischaemic-preconditioning-in-orthotopic-liver-transplantation-ripcolt-trial-a-pilot-randomized-controlled-feasibility-study
#14
Francis P Robertson, Rup Goswami, Graham P Wright, Charles Imber, Dinesh Sharma, Massimo Malago, Barry J Fuller, Brian R Davidson
BACKGROUND: Ischaemia Reperfusion (IR) injury is a major cause of morbidity, mortality and graft loss following Orthotopic Liver Transplantation (OLT). Utilising marginal grafts, which are more susceptible to IR injury, makes this a key research goal. Remote Ischaemic Preconditioning (RIPC) has been shown to ameliorate hepatic IR injury in experimental models. Whether RIPC can reduce IR injury in human liver transplant recipients is unknown. METHODS: Forty patients undergoing liver transplantation were randomized to RIPC or a sham...
June 23, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28647164/liver-transplantation-in-new-orleans-parity-in-a-world-of-disparity
#15
Alison A Smith, Michael Darden, Zaid Al-Qurayshi, Anil S Paramesh, Mary Killackey, Emad Kandil, Geoffrey Parker, Luis Balart, Paul Friedlander, Joseph F Buell
BACKGROUND: Racial disparity in access to liver transplantation among African Americans (AA) compared to Caucasians (CA) has been well described. The aim of this investigation was to examine the presentation of AA liver transplant recipients in a socioeconomically challenged region. METHODS: 680 adult liver transplant candidates and 233 resultant recipients between 2007 and 2015 were analyzed using univariate and multivariate analyses to evaluate factors significant for transplantation...
June 21, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28645571/a-pooled-analysis-of-combined-liver-and-inferior-vena-cava-resection-for-hepatic-malignancy
#16
Yanming Zhou, Lupeng Wu, Dong Xu, Tao Wan, Xiaoying Si
BACKGROUND: Limited data are currently available to address the safety and efficacy of combined resection of the liver and inferior vena cava (IVC) for hepatic malignancies. METHODS: A systematic review was performed to identify relevant studies. Pooled individual data were examined for the clinical outcome of combined resection of the liver and IVC for hepatic malignancies. RESULTS: A total of 258 patients were described in 38 articles eligible for inclusion...
June 20, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28629642/splenic-vein-reconstruction-is-unnecessary-in-pancreatoduodenectomy-combined-with-resection-of-the-superior-mesenteric-vein-portal-vein-confluence-according-to-short-term-outcomes
#17
Haruyoshi Tanaka, Akimasa Nakao, Kenji Oshima, Kiyotsugu Iede, Yukiko Oshima, Hironobu Kobayashi, Yasunori Kimura
BACKGROUND: Superior mesenteric vein-portal vein confluence resection combined with pancreatoduodenectomy (SMPVrPD) is occasionally required for resection of pancreatic head tumors. It remains unclear whether such situations require splenic vein (SV) reconstruction for decompression of left-sided portal hypertension (LSPH). METHODS: The data from 93 of 104 patients who underwent pancreatoduodenectomy (PD) for pancreatic head malignancies were reviewed. Surgical outcomes in three groups-standard PD (control group), PD combined with vascular resection and SV preservation (SVp group), and SMPVrPD with SV resection (SVr group)-were compared...
June 16, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28625391/twelve-year-experience-of-radical-but-conservative-liver-surgery-for-colorectal-metastases-impact-on-surgical-practice-and-oncologic-efficacy
#18
Guido Torzilli, Luca Viganò, Andrea Gatti, Guido Costa, Matteo Cimino, Fabio Procopio, Matteo Donadon, Daniele Del Fabbro
BACKGROUND: Liver surgery for colorectal metastases (CLM) is moving toward parenchyma-sparing approaches. The authors reported the technical feasibility of parenchyma-sparing hepatectomy for deeply located tumors, but its impact on daily practice and long-term outcomes remain unclear. METHODS: The patients undergoing liver resection (LR) for CLM with vascular contact (first-/second-order pedicle or hepatic vein (HV) trunk) were considered. Those undergoing major hepatectomy were excluded...
June 16, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28602644/increased-kinetic-growth-rate-during-late-phase-liver-regeneration-impacts-the-risk-of-tumor-recurrence-after-colorectal-liver-metastases-resection
#19
Georgios A Margonis, Kazunari Sasaki, Nikolaos Andreatos, Manijeh Zargham Pour, Nannan Shao, Mounes Aliyari Ghasebeh, Stefan Buettner, Efstathios Antoniou, Christopher L Wolfgang, Matthew Weiss, Ihab R Kamel, Timothy M Pawlik
BACKGROUND: Although experimental data strongly support the pro-tumorigenic role of postoperative liver regeneration, this hypothesis has not been clinically investigated. We aimed to examine the impact of liver regeneration determined by volumetric imaging on recurrence following resection of colorectal liver metastasis (CRLM). METHODS: Resected liver volume was subtracted from total liver volume (TLV) to define postoperative remnant liver volume (RLVp). Early and late kinetic growth rates (KGR) were defined as the postoperative increases in liver volume within 2-3 and 8-10 months from surgery, respectively, divided by the corresponding time interval...
June 8, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28602643/the-use-of-negative-pressure-wound-therapy-to-prevent-post-operative-surgical-site-infections-following-pancreaticoduodenectomy
#20
Richard A Burkhart, Ammar A Javed, Sean Ronnekleiv-Kelly, Michael J Wright, Katherine E Poruk, Frederic Eckhauser, Martin A Makary, John L Cameron, Christopher L Wolfgang, Jin He, Matthew J Weiss
BACKGROUND: Rates of superficial surgical site infection (SSI) following pancreaticoduodenectomy remain high. Following resection for cancer, complications such as SSI impact adjuvant therapy delivery and portend worse survival. An incisional negative pressure dressing (iVAC) has been demonstrated to reduce SSI in other high-risk cohorts. METHODS: Following a comprehensive effort to identify patients at high risk for SSI, the practice patterns at a single academic center shifted and iVAC use increased...
June 8, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
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