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Paediatric Respiratory Reviews

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https://www.readbyqxmd.com/read/29754778/long-acting-inhaled-bronchodilators-for-cystic-fibrosis
#1
Sherie Smith, Christopher T Edwards
No abstract text is available yet for this article.
April 22, 2018: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/29716830/pediatric-donation-after-circulatory-determination-of-death-pdcd-a-narrative-review
#2
REVIEW
Matthew J Weiss, Wendy Sherry, Laura Hornby
Pediatric donation after circulatory death (pDCD) is an established pathway for organ donation. It remains, however, a relatively rare event worldwide, and most clinicians outside of the pediatric intensive care unit (PICU) are unfamiliar with it. The goal of this review is to introduce the processes and concepts of pDCD. While most children die in circumstances that would not allow pDCD, many children that die after withdrawal of life sustaining therapy (WLST) may be eligible for donation of some organs. The potential benefits of this practice to patients on the wait list are well known, but donation can also be an opportunity to honor a patient's or family's desire to altruistically improve the lives of others...
April 14, 2018: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/29752125/persistent-and-progressive-long-term-lung-disease-in-survivors-of-preterm-birth
#3
REVIEW
Rhea Urs, Sailesh Kotecha, Graham L Hall, Shannon J Simpson
Preterm birth accounts for approximately 11% of births globally, with rates increasing across many countries. Concurrent advances in neonatal care have led to increased survival of infants of lower gestational age (GA). However, infants born <32 weeks of GA experience adverse respiratory outcomes, manifesting with increased respiratory symptoms, hospitalisation and health care utilisation into early childhood. The development of bronchopulmonary dysplasia (BPD) - the chronic lung disease of prematurity - further increases the risk of poor respiratory outcomes throughout childhood, into adolescence and adulthood...
April 13, 2018: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/29703693/hypersensitivity-reactions-to-intravenous-antibiotics-in-cystic-fibrosis
#4
REVIEW
Marie F A Wright, Andrew Bush, Siobhan B Carr
Hypersensitivity reactions to intravenous antibiotics are common in cystic fibrosis (CF). As well as causing immediate morbidity, the need for future avoidance of the causative antibiotic can have a long-term negative impact on CF management. This paper reviews the epidemiology and clinical presentation of hypersensitivity reactions in CF patients, and using an illustrative case describes a rare but severe form of delayed drug reaction for which a high index of suspicion is required.
April 5, 2018: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/29703692/new-and-developing-therapies-in-spinal-muscular-atrophy
#5
REVIEW
Didu Kariyawasam, Kate A Carey, Kristi J Jones, Michelle A Farrar
Great progress has been made in the clinical translation of several therapeutic strategies for spinal muscular atrophy (SMA), including measures to selectively address Survival Motor Neuron (SMN) protein deficiency with SMN1 gene replacement or modulation of SMN2 encoded protein levels, as well as neuroprotective approaches and supporting muscle strength and function. This review highlights these novel therapies. This is particularly vital with the advent of the first disease modifying therapy, which has brought to the fore an array of questions surrounding who, how and when to treat, and stimulated challenges in resource limited healthcare systems to streamline access for those eligible for drug therapy...
April 5, 2018: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/29685805/interventions-for-autumn-exacerbations-of-asthma-in-children
#6
Katharine C Pike, Melika Akhbari, Dylan Kneale, Katherine M Harris
No abstract text is available yet for this article.
April 4, 2018: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/29627169/side-effects-of-medications-used-to-treat-childhood-interstitial-lung-disease
#7
REVIEW
Oded Breuer, André Schultz
Interstitial lung disease in children (chILD) comprises a range of different rare diseases. There is limited evidence for the treatment of chILD and no randomised clinical trials of treatment have been undertaken. Most treatments are therefore prescribed off-label based on expert opinion. The off-label nature of prescription of drugs for chILD highlights the importance of a solid understanding of the side effects to facilitate risk-benefit assessment. The European Respiratory Society chILD guidelines recommend the use of systemic glucocorticosteroids, hydroxychloroquine and azithromycin...
March 17, 2018: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/29627168/cystic-fibrosis-papers-of-the-year-2017
#8
REVIEW
Iolo Doull
The number of published articles on Cystic Fibrosis (CF) continues to increase year on year. The evidence base for small molecule therapies in CF has continued to expand, with evidence for lumacaftor/ivacaftor in younger patients and longer-term evidence in adults, and pivotal studies on tezacaftor/ivacaftor. There were reports on emerging CFTR mutation agnostic therapies, and new evidence for long standing therapies.
March 15, 2018: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/29456076/inhaled-magnesium-sulfate-in-the-treatment-of-acute-asthma-in-children
#9
Rebecca Normansell, Rachel Knightly, Stephen J Milan, Jennifer A Knopp-Sihota, Brian H Rowe, Colin Powell
No abstract text is available yet for this article.
March 2018: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/29033214/the-evaluation-and-management-of-respiratory-disease-in-children-with-down-syndrome-ds
#10
REVIEW
Haya S Alsubie, Dennis Rosen
Children with Down syndrome (DS) have wide range of respiratory problems. Although underlying abnormalities in the respiratory system are important causes of morbidity and mortality in children with DS, particularly in the young, abnormalities in other organ systems may also impact respiratory function. A comprehensive evaluation of the child with DS and respiratory disease may prevent short-term morbidity and mortality, and reduce the incidence of complications in the long term. This review provides an overview of the various causes of respiratory disease, and insight into some of the newer therapies available to treat obstructive sleep apnea, in this population...
March 2018: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/29031795/pulmonary-sequelae-and-functional-limitations-in-children-and-adults-with-bronchopulmonary-dysplasia
#11
REVIEW
Daniel T Malleske, Olena Chorna, Nathalie L Maitre
Preterm infants with bronchopulmonary dysplasia (BPD) often suffer from life-long pulmonary impairments in pulmonary physical function. This review summarizes our current understanding of the chronic pulmonary impairments and physical functional limitations associated with BPD from preterm birth to adulthood. It also identifies opportunities for intervention in children and adults living with chronic lung disease (CLD) after preterm birth.
March 2018: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/28844414/childhood-community-acquired-pneumonia-a-review-of-etiology-and-antimicrobial-treatment-studies
#12
REVIEW
Gerdien A Tramper-Stranders
Community acquired pneumonia (CAP) is a leading cause of childhood morbidity worldwide. Because of the rising antimicrobial resistance rates and adverse effects of childhood antibiotic use on the developing microbiome, rational prescribing of antibiotics for CAP is important. This review summarizes and critically reflects on the available evidence for the epidemiology, etiology and antimicrobial management of childhood CAP. Larger prospective studies on antimicrobial management derive mostly from low- or middle-income countries as they have the highest burden of CAP...
March 2018: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/28709779/bronchial-hyper-responsiveness-after-preterm-birth
#13
REVIEW
Hege H Clemm, Merete Engeseth, Maria Vollsæter, Sailesh Kotecha, Thomas Halvorsen
Being born preterm often adversely affects later lung function. Airway obstruction and bronchial hyperresponsiveness (BHR) are common findings. Respiratory symptoms in asthma and in lung disease after preterm birth might appear similar, but clinical experience and studies indicate that symptoms secondary to preterm birth reflect a separate disease entity. BHR is a defining feature of asthma, but can also be found in other lung disorders and in subjects without respiratory symptoms. We review different methods to assess BHR, and findings reported from studies that have investigated BHR after preterm birth...
March 2018: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/28673835/when-should-parapneumonic-pleural-effusions-be-drained-in-children
#14
REVIEW
Gilberto Bueno Fischer, Helena Teresinha Mocelin, Cistiano Feijó Andrade, Edgar E Sarria
Pneumonia is an important health problem in children, and parapneumonic pleural effusion (PPE) is a frequent complication. There is no standard strategy for treating PPE, reflected in the few international guidelines that have been published on the issue. Compared to adults, there is no consensus on the utility of pleural fluid analysis in paediatric PPE. This is because of the lack of good evidence either in favour or against it and the risks of procedural sedation for acquiring pleural fluid for analysis to guide management...
March 2018: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/28583720/disease-modifying-drug-therapy-in-cystic-fibrosis
#15
REVIEW
Katharine Harman, Rebecca Dobra, Jane C Davies
Whilst substantial progress has been made in the treatment of cystic fibrosis, the disease still carries a significant burden in terms of symptoms, requirement for treatment and early mortality. The last decade has witnessed a new era in the development of small molecule drugs targeting the CFTR protein, which for the first time may provide a truly disease-modifying approach to treatment. This article reviews progress and highlights some of the current and future challenges in CFTR modulator therapies.
March 2018: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/28539256/anorexia-nervosa-in-cystic-fibrosis
#16
REVIEW
Lynette Linkson, Patricia Macedo, Felicity M R Perrin, Caroline M Elston
This article explores the challenges associated with diagnosing and managing eating disorders such as anorexia nervosa amongst adolescents and adults with cystic fibrosis. It reviews the known risk factors, generic verses disease specific eating disorder risk screening tools and considers the ethical dilemmas associated with critically low body mass indices. A case review is included to illustrate the complexities of managing both conditions in the context of declining respiratory function.
March 2018: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/28539217/cystic-fibrosis-papers-of-the-year-2016
#17
REVIEW
Iolo Doull
This is arguably the most exciting era in the treatment of Cystic Fibrosis (CF) with the emergence of potentially disease modifying therapies. The last year has seen fewer landmark papers, with the consolidation of existing knowledge and advances in the understanding of the patho-physiology and management of CF.
March 2018: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/28420572/nutritional-management-of-cystic-fibrosis-an-update-for-the-21st-century
#18
REVIEW
Sarah Collins
Nutritional management is an essential part of multidisciplinary care for infants, children and adults with cystic fibrosis (CF). In 2016 two updated nutritional consensus guidelines were published [1,2]. This review will explore some of the key points in the nutritional management of people with CF in the 21st Century.
March 2018: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/28416301/telemedicine-is-the-way-forward-for-the-management-of-cystic-fibrosis-the-case-in-favour
#19
REVIEW
Robert Ian Ketchell
Despite rapid changes in Information and Communication Technology, outpatient chronic disease management has changed very little in decades. However, the introduction of Telemedicine defined here as the use of remote patient-centred clinical services including the use of video and audio connections, telemonitoring and mobile applications provides us with an ideal opportunity to revolutionise care. Its appeal in cystic fibrosis (CF) care is clear offering better access to services, the opportunity of earlier intervention and improved monitoring and self management through virtual clinics and the use of real-time applications for adherence monitoring...
March 2018: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/28411069/clostridium-difficile-and-cystic-fibrosis-management-strategies-and-the-role-of-faecal-transplantation
#20
REVIEW
Roisin Dunwoody, Alan Steel, Jonathan Landy, Nicholas Simmonds
Clostridium difficile is a bacterial infection that colonises the gut in susceptible hosts. It is associated with exposure to healthcare settings and antibiotic use. It could be assumed that cystic fibrosis (CF) patients are a high-risk group for C.difficile. However, despite high carriage rates, CF patients have low rates of active disease. There are guidelines for the treatment of C.difficile, however little is published specific to treating C.difficile in CF. This article provides an overview of the current management strategies for C...
March 2018: Paediatric Respiratory Reviews
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