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Paediatric Respiratory Reviews

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https://www.readbyqxmd.com/read/28625493/question-12-what-do-you-consider-when-discussing-treatment-adherence-in-patients-with-cystic-fibrosis
#1
REVIEW
Mon Ohn, Dominic A Fitzgerald
No abstract text is available yet for this article.
April 27, 2017: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/28566196/ataluren-and-similar-compounds-specific-therapies-for-premature-termination-codon-class-i-mutations-for-cystic-fibrosis
#2
Aisha Aslam, Nikki Jahnke, Tracey Remmington, Kevin W Southern
No abstract text is available yet for this article.
April 27, 2017: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/28479112/interventions-to-improve-inhaler-technique-and-adherence-to-inhaled-corticosteroids-in-children-with-asthma
#3
Rebecca Normansell, Kayleigh Kew, Elizabeth Stovold, Alexander G Mathioudakis, Emma Dennett
No abstract text is available yet for this article.
April 8, 2017: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/28433261/dyspnea-in-children-what-is-driving-it-and-how-to-approach-it
#4
REVIEW
Larry C Lands
Dyspnea in children has important physical and psychosocial impact. It is useful to define the quality of the dyspnea and quantify its magnitude in a child-friendly manner. Through careful history taking and physical examination, a targeted investigation can lead to identification of the cause and potential treatment. This article provides a framework for the clinical approach to dyspnea in children, including important information to gather during the history, physical assessment, how to quantify dyspnea, and choice and use of laboratory measurements...
March 31, 2017: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/28539256/anorexia-nervosa-in-cystic-fibrosis
#5
REVIEW
Lynette Linkson, Patricia Macedo, Felicity M R Perrin, Caroline M Elston
This article explores the challenges associated with diagnosing and managing eating disorders such as anorexia nervosa amongst adolescents and adults with cystic fibrosis. It reviews the known risk factors, generic verses disease specific eating disorder risk screening tools and considers the ethical dilemmas associated with critically low body mass indices. A case review is included to illustrate the complexities of managing both conditions in the context of declining respiratory function.
March 23, 2017: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/28416135/all-the-rage-in-lung-disease-the-receptor-for-advanced-glycation-endproducts-rage-is-a-major-mediator-of-pulmonary-inflammatory-responses
#6
REVIEW
Elizabeth A Oczypok, Timothy N Perkins, Tim D Oury
The receptor for advanced glycation endproducts (RAGE) is a pro-inflammatory pattern recognition receptor (PRR) that has been implicated in the pathogenesis of numerous inflammatory diseases. It was discovered in 1992 on endothelial cells and was named for its ability to bind advanced glycation endproducts and promote vascular inflammation in the vessels of patients with diabetes. Further studies revealed that RAGE is most highly expressed in lung tissue and spurred numerous explorations into RAGE's role in the lung...
March 18, 2017: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/28408202/airway-clearance-techniques-for-primary-ciliary-dyskinesia-is-the-cystic-fibrosis-literature-portable
#7
REVIEW
Lynne Marie Schofield, Alistair Duff, Cathy Brennan
Primary Ciliary Dyskinesia (PCD) is a rare inherited disease with impaired mucociliary clearance. Airway clearance techniques (ACTs) are commonly recommended for patients with PCD to facilitate mucus clearance, despite a lack of evidence in this group. Current physiotherapy practice in PCD is based on evidence extrapolated from the field of Cystic Fibrosis (CF). This paper focuses on the available evidence and outlines challenges in extrapolating evidence between the conditions for best clinical practice.
March 16, 2017: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/28416301/telemedicine-is-the-way-forward-for-the-management-of-cystic-fibrosis-the-case-in-favour-the-debate-telemedicine-is-the-future-for-cf-care
#8
REVIEW
Robert Ian Ketchell
Despite rapid changes in Information and Communication Technology, outpatient chronic disease management has changed very little in decades. However, the introduction of Telemedicine defined here as the use of remote patient-centred clinical services including the use of video and audio connections, telemonitoring and mobile applications provides us with an ideal opportunity to revolutionise care. Its appeal in cystic fibrosis (CF) care is clear offering better access to services, the opportunity of earlier intervention and improved monitoring and self management through virtual clinics and the use of real-time applications for adherence monitoring...
March 15, 2017: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/28583720/disease-modifying-drug-therapy-in-cystic-fibrosis
#9
REVIEW
Katharine Harman, Rebecca Dobra, Jane C Davies
Whilst substantial progress has been made in the treatment of cystic fibrosis, the disease still carries a significant burden in terms of symptoms, requirement for treatment and early mortality. The last decade has witnessed a new era in the development of small molecule drugs targeting the CFTR protein, which for the first time may provide a truly disease-modifying approach to treatment. This article reviews progress and highlights some of the current and future challenges in CFTR modulator therapies.
March 14, 2017: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/28539217/cystic-fibrosis-papers-of-the-year-2016
#10
REVIEW
Iolo Doull
This is arguably the most exciting era in the treatment of Cystic Fibrosis (CF) with the emergence of potentially disease modifying therapies. The last year has seen fewer landmark papers, with the consolidation of existing knowledge and advances in the understanding of the patho-physiology and management of CF.
March 14, 2017: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/28420572/nutritional-management-of-cystic-fibrosis-an-update-for-the-21st-century
#11
REVIEW
Sarah Collins
Nutritional management is an essential part of multidisciplinary care for infants, children and adults with cystic fibrosis (CF). In 2016 two updated nutritional consensus guidelines were published [1,2]. This review will explore some of the key points in the nutritional management of people with CF in the 21st Century.
March 14, 2017: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/28411069/clostridium-difficile-and-cystic-fibrosis-management-strategies-and-the-role-of-faecal-transplantation
#12
REVIEW
Roisin Dunwoody, Alan Steel, Jonathan Landy, Nicholas Simmonds
Clostridium difficile is a bacterial infection that colonises the gut in susceptible hosts. It is associated with exposure to healthcare settings and antibiotic use. It could be assumed that cystic fibrosis (CF) patients are a high-risk group for C.difficile. However, despite high carriage rates, CF patients have low rates of active disease. There are guidelines for the treatment of C.difficile, however little is published specific to treating C.difficile in CF. This article provides an overview of the current management strategies for C...
March 14, 2017: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/28400242/the-impact-of-co-morbidity-in-childhood-cystic-fibrosis
#13
REVIEW
Julie A Duncan, Sarah M N Brown
A number of risk factors have been identified for deterioration of lung disease in children with Cystic Fibrosis (CF), and current management strategies are based on the prevention and treatment of such elements. Further challenge ensues when a patient has co-morbid disease in addition to CF, particularly when faced with rapidly deteriorating pulmonary status. It is difficult to measure the contribution of other pathologies to this decline and optimisation of both CF care and co-morbidity is paramount. This review explores the challenges faced when treating children with CF and co-morbid conditions, focussing on gastroesophageal reflux disease pre- and post-lung transplantation...
March 14, 2017: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/28400241/highlights-from-the-30th-north-american-cystic-fibrosis-conference-orlando-2016
#14
REVIEW
Anna Shawcross, Peter J Barry
This is a selection of papers presented at the 30th North American Cystic Fibrosis Conference held in Orlando in October 2016. The papers discussed are thought to be of particular interest to CF caregivers in the UK. We highlight the major themes covered in the conference including novel therapies, recently published and proposed guidelines and insights from registry studies.
March 14, 2017: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/28366680/telemedicine-is-the-way-forward-for-the-management-of-cystic-fibrosis-the-case-against
#15
REVIEW
Warren Lenney
It is reasonable to suggest that Telemedicine could help in the management of chronic diseases by giving patients more flexibility to remain at home with opportunities to forward electronic data to healthcare professionals, reduce hospital emergency attendances and reduce overall costs. The reality, particularly in cystic fibrosis care, is this has not happened. There is concern that home-generated lung function data is of poor quality and virtually no studies show improved outcomes. The UK has a poor record in developing novel IT programmes and we need many more well designed clinical studies in Telemedicine before wading in with ill-conceived expensive plans just because the idea seems interesting...
March 14, 2017: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/28372929/cystic-fibrosis-in-the-era-of-precision-medicine
#16
REVIEW
Shruti M Paranjape, Peter J Mogayzel
The treatment of people with cystic fibrosis (CF) has been transformed by the availability of drugs that target the basic chloride defect in the disease. The use of drugs that target specific molecular defects embodies the goals of precision medicine, which incorporate preventive and therapeutic strategies and takes into account differences among individuals. However, the entirety of CF care, from diagnosis to understanding the clinical phenotype and developing a therapeutic strategy, depends on taking into account individual characteristics to achieve optimal outcomes...
March 9, 2017: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/28237418/micrornas-in-lung-development-and-disease
#17
REVIEW
Dustin Ameis, Naghmeh Khoshgoo, Barbara M Iwasiow, Phillip Snarr, Richard Keijzer
MicroRNAs (miRNAs) are small (∼22 nucleotides), non-coding RNA molecules that regulate gene expression post-transcriptionally by inhibiting target mRNAs. Research into the roles of miRNAs in lung development and disease is at the early stages. In this review, we discuss the role of miRNAs in pediatric respiratory disease, including cystic fibrosis, asthma, and bronchopulmonary dysplasia.
March 2017: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/28139427/tobacco-vaccine-preventable-diseases-and-malnutrition-more-to-be-done-to-prevent-respiratory-disease
#18
EDITORIAL
Dominic A Fitzgerald
No abstract text is available yet for this article.
March 2017: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/28029591/cardiorespiratory-interactions-in-paediatrics-it-s-almost-always-the-circulation-stupid
#19
REVIEW
M L Rigby, M Rosenthal
The interaction of the heart and lungs is probably the most important aspect of life and survival. Fortunately, it is not difficult to understand the fundamentals. The purpose of the lungs and their ventilation is to present oxygen to the circulation via the alveoli and to receive carbon dioxide from the circulation and then expel it. The relations of the heart and lungs and the matching of blood flow to the various organs with ventilation and lung perfusion may be disrupted by a variety of congenital or acquired heart malformations...
March 2017: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/27964951/topical-cystic-fibrosis-transmembrane-conductance-regulator-gene-replacement-for-cystic-fibrosis-related-lung-disease
#20
L A Perry, J C Penny-Dimri, A A Aslam, T W Lee, K W Southern
No abstract text is available yet for this article.
March 2017: Paediatric Respiratory Reviews
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