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Clinical Breast Cancer

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https://www.readbyqxmd.com/read/28935542/phase-i-trial-of-veliparib-a-poly-adp-ribose-polymerase-inhibitor-plus-metronomic-cyclophosphamide-in-metastatic-her2-negative-breast-cancer
#1
Jesus Anampa, Alice Chen, John Wright, Margi Patel, Christine Pellegrino, Karen Fehn, Joseph A Sparano, Eleni Andreopoulou
BACKGROUND: Poly-ADP-ribose-polymerase is an essential nuclear enzyme, involved in base-excision repair of damaged DNA. Poly-ADP-ribose-polymerase inhibition sensitizes tumor cells to cytotoxic agents, which induce DNA damage, including cyclophosphamide (C), and metronomic dosing of C may optimize potential for synergy. METHODS: The primary objective of this phase I trial was to determine the safety and identify the recommended phase II dose of the combination of low-dose oral C (50, 75, 100, and 125 mg) once daily in combination with veliparib (V) (100, 200, and 300 mg) administered twice a day (BID) for 21-day cycles using a standard 3 + 3 design in patients with metastatic human epidermal growth factor receptor 2/neu-negative breast cancer...
September 1, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28916400/assessing-changes-in-the-activity-levels-of-breast-cancer-patients-during-radiation-therapy
#2
Colin E Champ, Nitin Ohri, Rainer J Klement, Matthew Cantor, Sushil Beriwal, Scott M Glaser, Ryan P Smith
BACKGROUND: Radiation therapy (RT) is often delivered after lumpectomy for women with breast cancer. A common perceived side effect of RT is fatigue, yet its exact effect on activity levels and sleep is unknown. In this study we analyzed the change in activity levels and sleep using an activity tracking device before, during, and after RT for women with early stage breast cancer and ductal carcinoma in situ who underwent adjuvant RT. PATIENTS AND METHODS: After institutional review board approval, activity levels were quantified before, during, and after RT with measurements of steps, miles walked, calories burned, and sleep metrics in 10 women fitted with activity trackers...
August 24, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28927692/prognostic-influence-of-tumor-stroma-on-breast-cancer-subtypes
#3
Sandra Cid, Noemi Eiro, Berta Fernández, Rosario Sánchez, Alejandro Andicoechea, Pablo Ignacio Fernández-Muñiz, Luis O González, Francisco J Vizoso
INTRODUCTION: The objective of the present work was to evaluate the impact of the phenotype of both intratumoral mononuclear inflammatory cells (MICs) and cancer-associated fibroblast (CAFs), assessed as to their expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) on prognosis in different breast cancer subtypes. MATERIALS AND METHODS: A total of 247 tumors of patients with primary ductal invasive breast cancer were categorized into 1 of 4 major subtypes, using the 3 standard immunohistochemical markers (estrogen receptor [ER], progesterone receptor [PR], and human epidermal growth factor receptor/Neu 2 [HER2] receptor status)...
August 19, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28899623/tyms-gene-polymorphisms-in-breast-cancer-patients-receiving-5-fluorouracil-based-chemotherapy
#4
Yvonne L Chao, Carey K Anders
No abstract text is available yet for this article.
August 19, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28890185/stromal-clusterin-expression-predicts-therapeutic-response-to-neoadjuvant-chemotherapy-in-triple-negative-breast-cancer
#5
Yihong Wang, Alexander S Brodsky, Jinjun Xiong, Mary L Lopresti, Dongfang Yang, Murray B Resnick
BACKGROUND: Expression of clusterin correlates with tumor progression and therapeutic response in several human malignancies, including breast cancer. However, its predictive value in the neoadjuvant setting in breast cancer remains unexplored. The objective of this explorative study was to determine whether clusterin expression in breast cancer correlated with clinical pathologic characteristics and whether its expression was predictive of response to neoadjuvant chemotherapy (NAC). MATERIALS AND METHODS: We determined the clusterin expression pattern in 72 triple negative breast cancers (TNBC) treated with NAC before surgery...
August 19, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28890184/evaluation-of-the-tumor-response-after-neoadjuvant-chemotherapy-in-breast-cancer-patients-correlation-between-dynamic-contrast-enhanced-magnetic-resonance-imaging-and-pathologic-tumor-cellularity
#6
Woo Jung Choi, Won Kyung Kim, Hee Jung Shin, Joo Hee Cha, Eun Young Chae, Hak Hee Kim
BACKGROUND: We evaluated the tumor response after neoadjuvant chemotherapy (NAC) in breast cancer patients using dynamic contrast-enhanced (DCE) magnetic resonance (MR) imaging parameters assessed using a commercially available computer-aided system. We also analyzed their correlation with pathologic tumor cellularity. MATERIALS AND METHODS: We retrospectively reviewed the data from 130 patients with breast cancer who had undergone NAC followed by surgery from January to October 2013...
August 18, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28890183/radiomics-analysis-on-ultrasound-for-prediction-of-biologic-behavior-in-breast-invasive-ductal-carcinoma
#7
Yi Guo, Yuzhou Hu, Mengyun Qiao, Yuanyuan Wang, Jinhua Yu, Jiawei Li, Cai Chang
INTRODUCTION: In current clinical practice, invasive ductal carcinoma is always screened using medical imaging techniques and diagnosed using immunohistochemistry. Recent studies have illustrated that radiomics approaches provide a comprehensive characterization of entire tumors and can reveal predictive or prognostic associations between the images and medical outcomes. To better reveal the underlying biology, an improved understanding between objective image features and biologic characteristics is urgently required...
August 18, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28888580/predicting-brain-metastasis-in-breast-cancer-patients-stage-versus-biology
#8
Hamdy A Azim, Raafat Abdel-Malek, Loay Kassem
BACKGROUND: Brain metastasis (BM) is a life-threatening event in breast cancer patients. Identifying patients at a high risk for BM can help to adopt screening programs and test preventive interventions. We tried to identify the incidence of BM in different stages and subtypes of breast cancer. PATIENTS AND METHODS: We reviewed the clinical records of 2193 consecutive breast cancer patients who presented between January 1999 and December 2010. We explored the incidence of BM in relation to standard clinicopathological factors, and determined the cumulative risk of BM according to the disease stage and phenotype...
August 18, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28888579/reliability-of-self-reported-treatment-data-by-patients-with-breast-cancer-compared-with-medical-record-data
#9
Melissa Kool, Esther Bastiaannet, Cornelis J H Van de Velde, Perla J Marang-van de Mheen
OBJECTIVES: Medical records are considered the gold standard for accurate treatment information. However, treatment data are increasingly obtained from questionnaires. It can be questioned whether self-reported treatment data are reliable, particularly because patients have to process a lot of information during their diagnosis and treatment process. The present study assesses the reliability of self-reported treatment data compared with medical records. METHODS: All patients with stage I, II, and III breast cancer (n = 606) in 5 hospitals in the west of the Netherlands were invited to complete a questionnaire 9 to 18 months after surgery...
August 18, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28887010/improved-performance-of-adjunctive-ultrasonography-after-mammography-screening-for-breast-cancer-among-chinese-females
#10
Henglei Dong, Yubei Huang, Fengju Song, Hongji Dai, Peifang Liu, Ying Zhu, Peishan Wang, Jiali Han, Xishan Hao, Kexin Chen
INTRODUCTION: Until now, no studies have investigated whether women other than those with dense breasts are suitable for adjunctive ultrasonography after negative mammography, and investigated whether all women with negative mammography are suitable for adjunctive ultrasonography. METHODS: Based on the Multi-modality Independent Screening Trial in China, a total of 31,918 women aged 45 to 65 years underwent both ultrasonography and mammography. Physicians performed ultrasonography and mammography separately and were blinded to each other's findings until their interpretations had been recorded...
August 15, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28939291/scalp-hypothermia-for-preventing-alopecia-during-chemotherapy-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#11
Hope S Rugo, Jeffrey Voigt
BACKGROUND: Alopecia is a side effect of chemotherapy and affects a patient's quality of life. Cooling the scalp during chemotherapy might reduce alopecia. The objective of this systematic and meta-analysis was to examine the effects of scalp cooling on the end point of alopecia in randomized controlled trials. MATERIALS AND METHODS: Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed. Electronic searches of databases were undertaken through February 2017...
August 10, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28888581/treatment-outcomes-and-prognostic-factors-in-male-patients-with-stage-iv-breast-cancer-a%C3%A2-population-based-study
#12
Wei Chen, Ying Huang, Gary D Lewis, Sean S Szeja, Sandra S Hatch, Andrew Farach, Darlene Miltenburg, E Brian Butler, Jenny C Chang, Bin S Teh
PURPOSE: Male breast cancer (MBC) represents < 1% of breast cancer patients, and limited data exists regarding metastatic MBC. To better characterize this patient subset, we performed a population-based study examining prognostic factors among patients with stage IV MBC. METHODS: Patients with stage IV MBC diagnosed between 1988 and 2012 were selected from the Surveillance, Epidemiology, and End Results database. Prognostic factors for overall survival (OS) and cause-specific survival (CSS) were evaluated...
August 10, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28867445/changing-natural-history-of-her2-positive-breast-cancer-metastatic-to-the-brain-in-the-era-of-new-targeted-therapies
#13
Louisa A Mounsey, Allison M Deal, Kevin C Keith, Julia M Benbow, Shlomit S Shachar, Timothy Zagar, E Claire Dees, Lisa A Carey, Matthew G Ewend, Carey K Anders
BACKGROUND: Given the wide adoption of human epidermal growth factor receptor 2 (HER2)-targeted therapies for advanced HER2-positive breast cancer, we studied the natural history of patients with HER2-positive breast cancer brain metastases (BCBM) over time. PATIENTS AND METHODS: Patients with HER2-positive BCBM identified from a prospectively maintained database at the University of North Carolina were divided into 3 cohorts by year of BCBM diagnosis. Cohorts were selected by year of HER2-targeted therapy US Food and Drug Administration approval...
August 9, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28867444/use-of-breast-magnetic-resonance-imaging-and-ultrasonography-for-identifying-nonpalpable-axillae-metastases-in-newly-diagnosed-breast-cancer-patients
#14
Juan Zhou, Feng-Juan Guo, Xiao-Peng Hao, Cui-Jing Chen, Ze-Fei Jiang, Gong-Jie Li
BACKGROUND: The metastasis of axillary lymph node (ALNs) is a critical step in the initial cancer staging of newly diagnosed breast cancer (BC) patients. Various imaging modalities can enhance the sensitivity of clinical examination in assessing the ALN status. PATIENTS AND METHODS: We enrolled 135 patients with BC, confirmed via histopathology, including 4 bilateral BC cases. A total of 139 ipsilateral ALNs adjacent to the breast lesion were examined via physical examination, ultrasonography (US), and magnetic resonance imaging (MRI); of these, 100 were nonpalpable ALNs, as determined by experienced breast surgeons and physicians...
August 9, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28830795/indications-for-postmastectomy-radiation-after-neoadjuvant-chemotherapy-in-ypn0-and-ypn1-3-axillary-node-positive-women
#15
Barbara Fowble, Abhishek Keshav Jairam, Frederick Wang, Anne Peled, Michael Alvarado, Cheryl Ewing, Laura Esserman, Catherine Park, Ann Lazar
INTRODUCTION: Downstaging with neoadjuvant chemotherapy (NAC) might obscure indications for postmastectomy radiation (PMRT). The degree of downstaging that results in local-regional recurrence (LRR) rates low enough to omit PMRT remains controversial. We examined the rate of LRR in women who received NAC who underwent mastectomy without PMRT. PATIENTS AND METHODS: Between 2004 and 2013, 81 women with stage I to IIIA breast cancer had NAC and mastectomy; 48 patients (59%) were clinical N0 and 33 patients (41%) were clinical N1; median age was 45 years; 33 patients (41%) had hormone receptor-positive (HR(+))HER2(-), 21 patients (26%) HR(+)HER2(+), 19 patients (23%) HR(-) HER2(-), and 7 patients (9%) HR(-)HER2(+) disease...
August 1, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28818493/progression-free-survival-and-time-to-progression-as-real-surrogate-end-points-for-overall-survival%C3%A2-in-advanced-breast-cancer-a-meta-analysis-of-37-trials
#16
Ling Li, Zhanyu Pan
BACKGROUND: Progression-free survival (PFS) and time to progression (TTP) have been reported to correlate with overall survival (OS) in several cancer types. To our knowledge, however, the correlation between them is unclear. METHODS: A literature-based meta-analysis was performed to assess whether PFS and TTP can be considered reliable surrogate end points for OS in a phase 3 clinical trial of advanced breast cancer (ABC). The median hazard ratios of PFS/TTP and OS were analyzed by determining their nonparametric Spearman rank correlation coefficients (Rs)...
July 25, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28843513/discrepancies-between-pathological-tumor-responses-and-estimations-of-complete-response-by-magnetic-resonance-imaging-after-neoadjuvant-chemotherapy-differ-by-breast-cancer-subtype
#17
Maki Namura, Hiroko Tsunoda, Hiroshi Yagata, Naoki Hayashi, Atsushi Yoshida, Emiko Morishita, Junko Takei, Koyu Suzuki, Hideko Yamauchi
INTRODUCTION: The influence of breast cancer (BC) subtype in discrepancies between pathologic complete response (pCR) and complete response by magnetic resonance imaging (MRI-CR) after neoadjuvant chemotherapy (NAC) have not been discussed well. We evaluated the association between BC subtype and pCR or only residual in situ lesion without invasive cancer (pCR/in situ(+)) in patients with MRI-CR (positive predictive value [PPV]). MATERIAL AND METHODS: From the data of 716 patients with primary BC who were diagnosed with invasive cancer and treated with NAC and then surgery from January 2009 to May 2014 at St...
July 21, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28801156/alarming-burden-of-triple-negative-breast-cancer-in-india
#18
REVIEW
Krishan K Thakur, Devivasha Bordoloi, Ajaikumar B Kunnumakkara
Breast cancer is the most prevalent cancer among women worldwide. Among the different breast cancer subtypes, triple-negative breast cancer (TNBC), which is more prevalent among younger age women, is the most aggressive form. Numerous clinicopathologic studies performed throughout the world strongly support the utterly poor prognoses and high recurrence rate of TNBC. The present report details a thorough data survey from Google and PubMed on the burden of TNBC worldwide and other associated factors, with special emphasis on its ever increasing incidence among Indian women...
July 20, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28784266/do-we-consider-locoregional-treatment-of-primary-site-in-patients-with-de-novo-stage-iv-breast-cancer-numerous-data-are-accumulating
#19
LETTER
Kadri Altundag
No abstract text is available yet for this article.
July 20, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28784267/refusal-of-cancer-directed-surgery-by-breast-cancer-patients-risk-factors-and-survival-outcomes
#20
Apostolos Gaitanidis, Michail Alevizakos, Christos Tsalikidis, Alexandra Tsaroucha, Constantinos Simopoulos, Michail Pitiakoudis
BACKGROUND: It has been reported that some patients with breast cancer may refuse cancer-directed surgery, but the incidence in the United States is not currently known. The purpose of this study was to identify the incidence, trends, risk factors, and eventual survival outcomes associated with refusal of recommended breast cancer-directed surgery. PATIENTS: A retrospective review of the Surveillance Epidemiology and End Results (SEER) database between 2004 and 2013 was performed...
July 18, 2017: Clinical Breast Cancer
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