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Clinical Breast Cancer

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https://www.readbyqxmd.com/read/28666812/single-agent-oral-vinorelbine-as-first-line-chemotherapy-for-endocrine-pretreated-breast-cancer-with-bone-metastases-and-no-visceral-involvement-norbreast-228-phase-ii-study
#1
Guenther G Steger, Adriana Dominguez, Natalia Dobrovolskaya, Francesco Giotta, Nicole Tubiana-Mathieu, Martin Pecherstorfer, Antonio Ardizzoia, Maria Blasinska-Morawiec, Enrique Espinosa, Gustavo Villanova
PURPOSE: Single-agent oral chemotherapy is widely used in patients with bone metastases without visceral involvement, especially in hormone receptor-positive metastatic breast cancer (mBC). However, this option has been poorly evaluated in clinical trials. METHODS: Eligible patients had mBC with predominantly bone but not visceral metastases, were receiving bisphosphonate therapy, and had previously received endocrine therapy (any setting) but not chemotherapy for mBC...
June 27, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28720418/invasive-lobular-breast-carcinoma-pleomorphic-versus-classical-subtype-associations-and%C3%A2-prognosis
#2
Ying L Liu, Christine Choi, Shing M Lee, Xiaobo Zhong, Hanina Hibshoosh, Kevin Kalinsky, Eileen P Connolly
BACKGROUND: Invasive pleomorphic lobular carcinoma (IPLC) has been associated with a worse prognosis compared with classic invasive lobular carcinoma (cILC); however, studies are small and conflicting. We seek to examine the prognosis of women with IPLC compared with cILC. METHODS: A retrospective review of women with breast cancer at a single institution from 2003 to 2012 identified 193 women with invasive lobular carcinoma (ILC). IPLC was defined as ILC with a pathological description of primarily pleomorphic features and Nottingham histological grade score of 7, 8, or 9 or overall grade of 3 or mixed classic/pleomorphic features and overall grade of 3...
June 23, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28712925/borderline-er-positive-primary-breast-cancer-gains-no-significant-survival-benefit-from-endocrine-therapy-a-systematic-review-and-meta-analysis
#3
REVIEW
Tong Chen, Ning Zhang, Meena S Moran, Peng Su, Bruce G Haffty, Qifeng Yang
Endocrine responsiveness of primary breast cancers with borderline estrogen receptor expression (ER(+) [1%-9%]) remains unclear. We aimed at investigating differences in endocrine responsiveness, prognosis, and clinicopathological characteristics between the ER(+) (1%-9%) cohort and the ER(-) cohort or ER(+) (≥10%) cohort. Eligible literature published from inception to November 20, 2016 was retrieved from the PubMed database on the basis of Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines...
June 23, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28709748/a-rare-presentation-of-primary-breast-carcinoma-in-the-vulva-a-case-report-and-literature-review
#4
Andre Lopes, Jessica St Louis, Marcelo Luiz Balancin, Angelica Nogueira-Rodrigues, Luana C F F Silva, Eduardo Paulino, Bianca Silveira Sá, Alexandra Bukowski, Edison Mantovani Barbosa, Ronaldo Lúcio Rangel Costa, Paul E Goss
No abstract text is available yet for this article.
June 23, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28705541/risk-factors-affecting-breast-cancer-related-lymphedema-serial-body-weight-change-during-neoadjuvant-anthracycline-plus-cyclophosphamide-followed-by-taxane
#5
Sungmin Park, Jeong Eon Lee, Jonghan Yu, Hyun-June Paik, Jai Min Ryu, Isaac Kim, Soo Youn Bae, Se Kyung Lee, Seok Won Kim, Seok Jin Nam, Eun-Kyu Kim, Eunyoung Kang, Eun Joo Yang
INTRODUCTION: The aim of our study was to analyze the risk of lymphedema (LE) according to the clinicopathologic factors and to investigate the serial change in body weight during neoadjuvant anthracycline plus cyclophosphamide followed by taxane and its correlation with the incidence of LE. PATIENTS AND METHODS: We performed a retrospective 2-center study of 406 patients who had undergone neoadjuvant chemotherapy (NAC) followed by surgery from 2007 to 2014. The regimen included 4 cycles of anthracycline plus cyclophosphamide, followed by 4 cycles of taxane...
June 21, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28689012/locoregional-treatment-of-the-primary-tumor-in-patients-with-de-novo-stage-iv-breast-cancer-a-radiation-oncologist-s-perspective
#6
Seo Hee Choi, Jun Won Kim, Jinhyun Choi, Joohyuk Sohn, Seung Il Kim, Seho Park, Hyung Seok Park, Joon Jeong, Chang-Ok Suh, Ki Chang Keum, Yong Bae Kim, Ik Jae Lee
BACKGROUND: The aim of this study was to assess the outcomes of patients with de novo stage IV breast cancer after locoregional treatment (LRT) of primary site. PATIENTS AND METHODS: We studied 245 patients diagnosed with de novo stage IV breast cancer. LRT of the primary tumor (+ systemic therapy) was performed in 82 (34%) patients (surgery, 27; surgery + radiotherapy (RT), 46; and RT, 9). Among those undergoing surgery, 64 (88%) patients underwent mastectomy, and 9 (12%) patients underwent breast-conserving surgery (BCS)...
June 17, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28689011/coexistence-of-ductal-carcinoma-within-mammary-phyllodes-tumor-a-review-of-557-cases-from-a-20-year-region-wide-database-in-hong-kong-and-southern-china
#7
Michael Co, Gary M Tse, Clement Chen, Jiannan Wei, Ava Kwong
INTRODUCTION: Phyllodes tumor (PT) is an uncommon fibroepithelial tumor of the breast showing predominately proliferation of the stromal component. The presence of ductal carcinoma in situ (DCIS) or invasive ductal carcinoma is rare, with only a few cases reported in the literature. METHODS: A retrospective review of a prospectively maintained database was performed. Patients who were treated for PT in 5 hospitals in Hong Kong and Shenzhen, China over a period of 20 years (1997-2016) were evaluated...
June 17, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28666813/patient-case-lessons-endocrine-management-of-advanced-breast-cancer
#8
REVIEW
Nicholas J Robert, Neelima Denduluri
Advances in treatment for women with advanced breast cancer (ABC) have led to improvements in survival. Although the condition remains incurable, treatment goals focus on stabilizing disease, prolonging life, and maintaining patient quality of life. Hormone receptor-positive (HR(+)) subtypes constitute the majority of breast cancers, and an increasing number of effective endocrine therapies are available. Although practice guidelines provide important recommendations and principles for treatment selection, the choice of specific agents from among existing options should be customized to the individual based on patient and disease characteristics, as well as the nature and duration of response to previous treatments...
June 7, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28645722/circulating-bone-related-markers-and-ykl-40-versus-her2-and-topo2a-in-bone-metastatic-and-nonmetastatic-breast-cancer-diagnostic-implications
#9
Olfat Gamil Shaker, Hebatullah Samy Helmy
BACKGROUND: The bone represents one of the most common sites of metastases in breast cancer. The aim of the current study was to evaluate the diagnostic potential of several circulating markers to detect metastasis to bones in patients with breast cancer. PATIENTS AND METHODS: Receptor activator of Nuclear Factor-kappa β (NF-Kβ) ligand (RANKL), osteoprotegrin (OPG), vitamin D (VIT D), Chitinase-3-like protein 1; also known as YKL-40, topoisomerase IIα (TOPO2a), and human epidermal growth factor receptor 2 (HER2) were measured in blood samples obtained from 122 patients with breast cancer and 25 healthy controls...
June 7, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28648841/fine-needle-aspiration-combined-with-matrix-assisted-laser-desorption-ionization-time-of-flight-mass-spectrometry-to-characterize-lipid-biomarkers-for-diagnosing-accuracy-of-breast-cancer
#10
Yi-Tzu Cho, Hung Su, Yi-Yan Chiang, Jentaie Shiea, Shyng-Shiou F Yuan, Wen-Chun Hung, Yao-Tsung Yeh, Ming-Feng Hou
BACKGROUND: Fine needle aspiration (FNA) cytology has been widely used for pathologic assessment of breast lesions. However, the examination suffers a risk of false-negative results owing to insufficient sample volumes, inaccurate sampling positions, nondefinitive cytologic features, or suboptimal cell preservation. One approach to improve its accuracy is using modern mass spectrometry to detect disease biomarkers, of which the tissue samples are collected through FNA. METHODS: The biological compounds in the FNA tissue samples were extracted and characterized by matrix-assisted laser desorption ionization time-of-flight/mass spectrometry (MALDI-TOF/MS)...
May 25, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28629952/analysis-of-outcomes-using-hypofractionated-tumor-bed-boost-combined-with-hypofractionated-whole-breast-irradiation-for-early-stage-breast-cancer
#11
Esther Yu, David Huang, Kara Leonard, Thomas Dipetrillo, David Wazer, Jaroslaw Hepel
INTRODUCTION: Tumor bed boost improves local control and is an important part of breast-conserving therapy. Data on the use of a hypofractioned tumor bed boost are needed. We performed a retrospective analysis of patients treated with hypofractionated whole breast irradiation (WBI) and hypofractionated boost to examine acute and delayed outcomes. MATERIALS AND METHODS: We examined the records of patients treated with hypofractionated WBI and tumor bed boost after lumpectomy for Stage 0 to II breast cancer...
May 25, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28624156/a-noninvasive-blood-based-combinatorial-proteomic-biomarker-assay-to-detect-breast-cancer-in-women-under-the-age-of-50-years
#12
Ana P Lourenco, Kasey L Benson, Meredith C Henderson, Michael Silver, Elias Letsios, Quynh Tran, Kelly J Gordon, Sherri Borman, Christa Corn, Rao Mulpuri, Wendy Smith, Josie Alpers, Carrie Costantini, Nitin Rohatgi, Rebecca Yang, Ali Haythem, Shah Biren, Michael Morris, Fred Kass, David E Reese
BACKGROUND: Despite significant advances in breast imaging, the ability to detect breast cancer (BC) remains a challenge. To address the unmet needs of the current BC detection paradigm, 2 prospective clinical trials were conducted to develop a blood-based combinatorial proteomic biomarker assay (Videssa Breast) to accurately detect BC and reduce false positives (FPs) from suspicious imaging findings. PATIENTS AND METHODS: Provista-001 and Provista-002 (cohort one) enrolled Breast Imaging Reporting and Data System 3 or 4 women aged under 50 years...
May 23, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28655486/vaginal-atrophy-in-breast-cancer-survivors-attitude-and-approaches-among-oncologists
#13
Nicoletta Biglia, Valentina Elisabetta Bounous, Marta D'Alonzo, Laura Ottino, Valentina Tuninetti, Elisabetta Robba, Tania Perrone
BACKGROUND: Vulvovaginal atrophy (VVA) is a relevant problem for breast cancer survivors (BCSs), in particular for those who receive aromatase inhibitors (AIs). We conducted a survey, to assess the attitude of oncologists toward the diagnosis and treatment of VVA in BCSs. MATERIALS AND METHODS: In 2015, 120 computer-assisted Web interviews were performed among breast oncologists. RESULTS: According to oncologists' perceptions, 60% of postmenopausal BCSs and 39...
May 19, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28606800/physical-exercise-positively-influences-breast-cancer-evolution
#14
REVIEW
Kalliopi Adraskela, Eleftheria Veisaki, Michael Koutsilieris, Anastassios Philippou
Breast cancer is one of the most commonly diagnosed types of cancer in women. Its pathogenesis involves genetic, hormonal, and environmental factors. A large body of evidence indicates that physical activity has positive effects on every aspect of breast cancer evolution, including prevention, medical treatment, and aftercare clinical settings. Thus, different types of exercise can influence the prevention and progression of the disease through several common mechanisms, such as reduction of insulin resistance and improvement of immunity and cardiovascular function...
May 19, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28601383/pretreatment-serum-concentration-of-vitamin-d-and-breast-cancer-characteristics-a-prospective-observational-mediterranean-study
#15
Giuseppe Buono, Mario Giuliano, Carmine De Angelis, Rossella Lauria, Valeria Forestieri, Matilde Pensabene, Dario Bruzzese, Sabino De Placido, Grazia Arpino
BACKGROUND: Recent studies of the correlation between breast cancer (BC) and vitamin D yielded contrasting results. Although preclinical and clinical evidence has implicated vitamin D in BC prevention and outcome, little is known about the link between vitamin D and specific BC histologically defined subtypes. In the attempt to clarify this association we correlated vitamin D levels with BC characteristics. PATIENTS AND METHODS: We enrolled 220 pre- and postmenopausal women with early BC in this prospective observational trial...
May 19, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28600146/surgical-staging-of-the-axilla-is-it-on-its-way-out-a-retrospective-study-and-review-of-the-literature
#16
Debkumar Chowdhury, Ionela Drehuta, Sanjeet Bhattacharya
INTRODUCTION: Sentinel lymph node biopsy (SLNB) is the reference standard for axillary staging in all patients with invasive breast cancer. Surgical practices are being reviewed for a more conservative approach to the axilla. PATIENTS AND METHODS: In this audit, we studied the incidence of axillary disease in patients with ultrasound negative axilla. The selection criteria are similar to an ongoing national study: female patients, age > 50 years, primary breast lesion < 1...
May 19, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28595965/low-expression-of-estrogen-receptor-%C3%AE-and-progesterone-receptor-in-human-breast-cancer-tissues-is-associated-with-high-grade-human-cytomegalovirus-protein-expression
#17
Afsar Rahbar, Joel Touma, Helena Costa, Belghis Davoudi, Ida Rashid Bukholm, Torill Sauer, Katja Vetvik, Jürgen Geisler, Cecilia Söderberg-Naucler
BACKGROUND: The underlying mechanisms for breast cancer (BC) are largely unknown. We investigated possible correlations between the expression levels of human cytomegalovirus (HCMV) proteins and established histopathological markers of BC, including expression of estrogen receptor (ER)-α, the progesterone receptor (PgR), and HER2. MATERIALS AND METHODS: We retrospectively examined paraffin-embedded biopsy specimens of BC (n = 62), ductal carcinoma in situ (n = 19), and adjacent normal breast tissue (n = 42) for HCMV immediate-early protein (IE), HCMV late antigen, HCMV DNA and RNA, and investigated possible correlations between them and expression of ER-α, PgR, and HER2...
May 11, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28625341/efficacy-and-toxicity-of-metronomic-chemotherapy-in-metastatic-breast-cancer-egyptian-experience
#18
Marwa Mahmoud Hussein, Rabab Mohamed Gaafar, Ahmed Mostafa Abdel-Warith, Wafaa Abdallah Ahmed, Nasr Mohamed Ali Allahloubi, Salem Eid Salem, Ibrahem Mohamed Abdel-Salam
BACKGROUND: Metronomic chemotherapy (MC) has shown efficacy in patients with metastatic breast cancer (MBC). We therefore tested the efficacy and toxicity of MC in pretreated MBC. PATIENTS AND METHODS: This prospective phase II study included 50 patients with heavily pretreated MBC who received MC in the form of continuous oral cyclophosphamide 50 mg/day and oral methotrexate 2.5 mg twice per day on days 1 and 2 every week. The primary end point was progression-free survival (PFS), whereas the secondary end points were response rate, overall survival (OS), and safety...
May 8, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28602452/disease-severity-presentation-and-clinical-outcomes-among-adolescents-with-malignant-breast-neoplasms-a-20-year-population-based-outcomes-study-from-the-seer-database-1973-2009
#19
Vijayashree Murthy, Shonali Pawar, Ronald S Chamberlain
INTRODUCTION: Primary breast cancer in adolescents is extremely rare and thus is not widely studied. This study aimed to evaluate trends, characteristics, and outcomes among a cohort of adolescents with breast cancer. PATIENTS AND METHODS: A total of 657,712 female patients with breast cancer from Surveillance Epidemiology and End Results (SEER) database (1973-2009) were analyzed, and 91 adolescents were identified. Three age groups (under 20 years, 20-50 years or premenopausal, and > 50 years or postmenopausal) were compared for tumor size, stage, receptor status, and outcomes...
May 8, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28601382/long-term-follow-up-of-node-negative-breast-cancer-patients-evaluated-via-sentinel-node-biopsy-after-neoadjuvant-chemotherapy
#20
Hiroko Nogi, Ken Uchida, Rei Mimoto, Makiko Kamio, Hisashi Shioya, Yasuo Toriumi, Masafumii Suzuki, Eijiro Nagasaki, Tadashi Kobayashi, Hiroshi Takeyama
BACKGROUND: Sentinel node biopsy (SNB) is used to accurately assess axillary lymph node status in patients with node-negative breast cancer. However, its use after neoadjuvant chemotherapy (NAC) is controversial. We retrospectively assessed the usefulness of SNB after NAC by comparing axillary recurrence rates and other parameters in patients with clinically node-negative breast cancer who underwent SNB after NAC or without NAC. PATIENTS AND METHODS: At our hospital, 1179 patients with clinically node-negative breast cancer underwent SNB from April 2007 to December 2013...
May 8, 2017: Clinical Breast Cancer
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