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Clinical Breast Cancer

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https://www.readbyqxmd.com/read/28202253/flap-fixation-using-tissue-glue-or-sutures-appears-to-reduce-seroma-aspiration-after-mastectomy-for-breast-cancer
#1
James van Bastelaar, Lotte L B Theunissen, Maarten G J Snoeijs, Geerard L Beets, Yvonne L J Vissers
BACKGROUND: Up to 90% of patients undergoing breast cancer surgery suffer from seroma formation, which can cause discomfort and various complications after mastectomy. This retrospective observational cohort study aimed to elucidate whether flap fixation with fibrin sealant (ARTISS) tissue glue reduces seroma formation and seroma aspiration after mastectomy when compared with flap fixation using Vicryl sutures and when compared with a conventional wound closure technique. METHODS: All patients undergoing mastectomy due to invasive breast cancer or ductal carcinoma in situ were eligible for inclusion...
January 24, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28188108/magnetic-resonance-spectroscopy-detected-change-in-marrow-adiposity-is-strongly-correlated-to-postmenopausal-breast-cancer-risk
#2
Guanwu Li, Zheng Xu, Alex Zhuang, Shixin Chang, Lingmi Hou, Yongsheng Chen, Maki Polat, Dongmei Wu
PURPOSE: To determine whether marrow fat fraction (FF) is correlated with postmenopausal breast cancer risk and clinicopathological characteristics of breast cancer. METHODS: Fifty-six patients with newly diagnosed and histologically confirmed postmenopausal breast cancer and 56 healthy controls underwent serologic test and magnetic resonance spectroscopy-based FF measurements. Data were analyzed by logistic multivariate regression models to determine the independent predictors of breast cancer risk and clinicopathological characters of breast cancer...
January 18, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28188107/inflammation-by-breast-implants-and-adenocarcinoma-not-always-a-bad-company
#3
Monia Orciani, Giulia Sorgentoni, Fabiola Olivieri, Monica Mattioli-Belmonte, Giovanni Di Benedetto, Roberto Di Primio
BACKGROUND: Inflammation and tumor are now an inseparable binomial. Inflammation may also derive by the use of breast implants followed by the formation of a periprosthetic capsule. It is known that tumor cells, in an inflamed microenvironment, can profit by the paracrine effect exerted also by mesenchymal stem cells (MSCs). Here we evaluated the role of inflammation on the immunobiology of MSCs before and after cocultures with cells derived from breast adenocarcinoma. METHODS: MSCs derived from both inflamed (I-MSCs) and control (C-MSCs) tissues were isolated and cocultured with MCF7 cells derived from breast adenocarcinoma...
January 17, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28209330/role-of-magnetic-resonance-imaging-in-detection-of-pathologic-complete-remission-in-breast-cancer-patients-treated-with-neoadjuvant-chemotherapy-a-meta-analysis
#4
REVIEW
Yan-Lin Gu, Si-Meng Pan, Jie Ren, Zhi-Xue Yang, Guo-Qin Jiang
Pathologic complete remission after neoadjuvant chemotherapy has a role in guiding the management of breast cancer. The present meta-analysis examined the accuracy of contrast-enhanced magnetic resonance imaging (CE-MRI) and diffusion-weighted magnetic resonance imaging (DW-MRI) in detecting the response to neoadjuvant chemotherapy and compared CE-MRI with ultrasonography, mammography, and positron emission tomography/computed tomography (PET/CT). Medical subject heading terms and related keywords were searched to generate a compilation of eligible studies...
January 11, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28190761/prevalence-of-circulating-tumor-cells-after-adjuvant-chemotherapy-with-or-without-anthracyclines-in-patients-with-her2-negative-hormone-receptor-positive-early-breast-cancer
#5
Amelie Schramm, Fabienne Schochter, Thomas W P Friedl, Nikolaus de Gregorio, Ulrich Andergassen, Marianna Alunni-Fabbroni, Elisabeth Trapp, Bernadette Jaeger, Georg Heinrich, Oumar Camara, Thomas Decker, Angelika Ober, Sven Mahner, Tanja N Fehm, Klaus Pantel, Peter A Fasching, Andreas Schneeweiss, Wolfgang Janni, Brigitte K Rack
BACKGROUND: Use of anthracycline-based chemotherapy in patients with early breast cancer (EBC) has been well-established but is often associated with cardiotoxicity. Based on data suggesting a limited benefit of anthracyclines in human epidermal growth factor receptor 2 (HER2)-negative patients, the Simultaneous Study of Docetaxel Based Anthracycline Free Adjuvant Treatment Evaluation, as well as Life Style Intervention Strategies (SUCCESS) C study randomized patients to either anthracycline-containing or anthracycline-free chemotherapy...
January 10, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28169145/poor-prognosis-of-lower-inner-quadrant-in-lymph-node-negative-breast-cancer-patients-who-received-no-chemotherapy-a-study-based-on-nationwide-korean-breast-cancer-registry%C3%A2-database
#6
Ki-Tae Hwang, Jongjin Kim, Eun-Kyu Kim, Sung Hoo Jung, Guiyun Sohn, Seung Il Kim, Joon Jeong, Hyouk Jin Lee, Jin Hyun Park, Sohee Oh
BACKGROUND: We aimed to investigate the prognostic influence of primary tumor site on the survival of patients with breast cancer. PATIENTS AND METHODS: Data of 63,388 patients with primary breast cancer from the Korean Breast Cancer Registry were analyzed. Primary tumor sites were classified into 5 groups: upper outer quadrant, lower outer quadrant, upper inner quadrant, lower inner quadrant (LIQ), and central portion. We analyzed overall survival (OS) and breast cancer-specific survival (BCSS) according to primary tumor site...
January 10, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28161131/use-of-low-thrombin-fibrin-sealant-glue-after-axillary-lymphadenectomy-for-breast-cancer-to-reduce-hospital-length-and-seroma
#7
Angelica Conversano, Chafika Mazouni, Anne Thomin, Amélie Gaudin, Marie Fournier, Françoise Rimareix, Julia Bonastre
BACKGROUND: Axillary lymphadenectomy for primary breast cancer produces a non-negligible rate of postoperative lymphorrhea, prolonged hospital stays, and multiple seroma punctures. We evaluated the impact of low-thrombin fibrin sealant glue on surgical wounds in patients undergoing axillary lymph node dissection for breast cancer. METHODS: We conducted an observational study of 149 patients who underwent axillary lymphadenectomy for primary breast cancer between January 2014 and December 2015...
January 10, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28196771/liver-metastases-from-breast-cancer-what-role-for-surgery-indications-and-results
#8
REVIEW
Nicolas Golse, René Adam
Liver metastases from breast cancer (LMBC) have long been considered as a systemic disease because of the hematological route of dissemination, requiring noncurative management. In fact, despite recent advances in drug therapies personalized to tumor phenotype, the chances of a cure are nil and there is little hope of long-term survivors after nonsurgical management alone. By contrast, there is a growing evidence in the literature for satisfactory long-term results after a combination of chemotherapy and liver resection, with 5-year survival reaching >40% in some series...
January 9, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28190760/a-guide-to-prepectoral-breast-reconstruction-a%C3%A2-new-dimension-to-implant-based-breast-reconstruction
#9
REVIEW
Raghavan Vidya, Fahad Mujtaba Iqbal
Acellular dermal matrix has revolutionized implant-based breast reconstruction. Breast reconstruction has evolved from the traditional submuscular to the new prepectoral implant based (also known as muscle-sparing) reconstruction. The new technique is emerging as a highly popular surgery owing to its more minimal approach. We conducted a narrative review to guide prepectoral breast reconstruction, highlighting the technique, the need for appropriate patient selection, and areas for further research. We show that prepectoral breast reconstruction is safe, feasible, and has excellent short-term outcomes (cosmesis and patient satisfaction)...
January 9, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28185739/breast-cancer-outcomes-after-diagnosis-of-hormone-positive-breast-cancer-and-subsequent-pregnancy-in-the-tamoxifen-era
#10
Lauren Nye, Alfred Rademaker, William J Gradishar
BACKGROUND: Counseling patients regarding the risk of future pregnancy on hormone receptor-positive breast cancer outcomes is difficult because of the minimal data and understanding of pregnancy on the breast environment. PATIENTS AND METHODS: The present retrospective analysis included 32 premenopausal women with a diagnosis of estrogen receptor-positive breast cancer from 2000 to 2010 and subsequent pregnancy within 5 years. The control cohort included 29 women matched for age and stage of breast cancer who had not become pregnant...
January 9, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28162950/nipple-sparing-mastectomy-for-the-management-of-recurrent-breast-cancer
#11
Brittany L Murphy, Judy C Boughey, Tina J Hieken
INTRODUCTION: For patients who have an ipsilateral breast cancer recurrence following prior breast-conserving surgery and radiation, total mastectomy generally is recommended. However, little is known about the suitability and outcomes of nipple-sparing mastectomy (NSM) with immediate breast reconstruction for the treatment of recurrent breast cancer, prompting this investigation. PATIENTS AND METHODS: From 1008 patients scheduled for NSM for breast cancer treatment at our institution between January 2009 and June 2016, we identified all patients who underwent surgery for ipsilateral recurrent breast cancer...
January 9, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28161133/new-data-about-first-line-all-oral-vinorelbine-and-capecitabine-in-her2-negative-metastatic-breast-cancer-confirms-results-of-meta-analysis
#12
LETTER
Kadri Altundag
No abstract text is available yet for this article.
January 9, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28161132/genomic-profiling-of-brain-metastasis-and-matched-primary-triple-negative-breast-cancer
#13
LETTER
Kadri Altundag
No abstract text is available yet for this article.
January 9, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28189497/correlates-of-triple-negative-breast-cancer-and-chemotherapy-patterns-in-black-and-white-women-with-breast-cancer
#14
Vanessa B Sheppard, Luciane R Cavalli, Chiranjeev Dash, Yasmine M Kanaan, Asma A Dilawari, Sara Horton, Kepher H Makambi
BACKGROUND: Triple negative breast cancer (TNBC) tumors are estrogen receptor-negative, progesterone receptor-negative, and human epidermal growth factor-negative. TNBC is responsive to chemotherapy, but chemotherapy might be underused in some patient subgroups. The goal of the present study was to characterize the patterns of chemotherapy use (uptake and completion) in TNBC patients. PATIENTS AND METHODS: Women with primary invasive, nonmetastatic breast cancer were recruited in Washington, DC, and Detroit...
January 6, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28139434/synchronous-bilateral-breast-cancer-in-a-patient-with-nager-syndrome
#15
Ryan A Denu, Mark E Burkard
No abstract text is available yet for this article.
January 5, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28111130/added-value-of-breast-mri-for-preoperative-diagnosis-of-ductal-carcinoma-in-situ-diagnostic-performance-on-362-patients
#16
Antonella Petrillo, Roberta Fusco, Mario Petrillo, Flavia Triunfo, Salvatore Filice, Paolo Vallone, Sergio Venanzio Setola, Mariarosaria Rubulotta, Maurizio Di Bonito, Massimo Rinaldo, Massimiliano D'Aiuto, Arturo Brunetti
INTRODUCTION: The purpose of this study was to evaluate the added value of breast magnetic resonance imaging (MRI) in preoperative diagnosis of ductal carcinoma in situ (DCIS). We reviewed our institution database of 3499 consecutive patients treated for breast cancer. PATIENTS AND METHODS: A total of 362 patients with histologically proven DCIS were selected from the institutional database. Of these, 245 (67.7%) preoperatively underwent conventional imaging (CI) (mammography/ultrasonography) (CI group), and 117 (32...
December 29, 2016: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28110902/dedicated-breast-positron-emission-tomography-for-the-evaluation-of-early-response-to-neoadjuvant-chemotherapy-in-breast-cancer
#17
Ella F Jones, Kimberly M Ray, Wen Li, Youngho Seo, Benjamin L Franc, Amy J Chien, Laura J Esserman, Miguel H Pampaloni, Bonnie N Joe, Nola M Hylton
No abstract text is available yet for this article.
December 29, 2016: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28089627/the-relationship-between-tamoxifen-associated-nonalcoholic-fatty-liver-disease-and-the-prognosis-of-patients-with-early-stage-breast-cancer
#18
Meiying Yan, Jingxuan Wang, Qijia Xuan, Tieying Dong, Juan He, Qingyuan Zhang
PURPOSE: To investigate the relationship between tamoxifen-associated nonalcoholic fatty liver disease (NAFLD) and survival outcomes in patients with breast cancer. METHODS: Patients with early-stage invasive breast cancer after curative resection from January 2009 to June 2011 were selected. A total of 646 patients who were treated with tamoxifen were included. Patients diagnosed with NAFLD on ultrasonography were classified into the NAFLD and non-NAFLD groups...
December 24, 2016: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28089626/cisplatin-induces-apoptosis-through-the-endoplasmic-reticulum-mediated-calpain-1-pathway-in-triple-negative-breast-cancer-cells
#19
Shadia M Al-Bahlani, Khadija H Al-Bulushi, Zaina M Al-Alawi, Nadia Y Al-Abri, Zuweina R Al-Hadidi, Shaikha S Al-Rawahi
BACKGROUND: Breast cancer is the most common cancer in women worldwide. Triple-negative breast cancer (TNBC) is an aggressive type that can be treated using platinum-based chemotherapy such as cisplatin (cis-diamminedichloroplatinum II). Although the calpain protein is essential in many cellular processes, including apoptosis, cell signaling, and proliferation, its role in cisplatin-induced apoptosis in TNBC cells is not fully understood. The present study assessed calpain 1-dependent, cisplatin-induced apoptosis in TNBC cells...
December 24, 2016: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28089283/myc-amplification-as-a-predictive-factor-of-complete-pathologic-response-to-docetaxel-based-neoadjuvant-chemotherapy-for-breast-cancer
#20
Cynthia Brito Lins Pereira, Mariana Ferreira Leal, Eliana Saul Furquim Werneck Abdelhay, Sâmia Demachki, Paulo Pimentel Assumpção, Mirian Carvalho de Souza, Caroline Aquino Moreira-Nunes, Adriana Michiko da Silva Tanaka, Marília Cardoso Smith, Rommel Rodríguez Burbano
BACKGROUND: Neoadjuvant chemotherapy is a standard treatment for stage II and III breast cancer. The identification of biomarkers that may help in the prediction of response to neoadjuvant therapies is necessary for a more precise definition of the best drug or drug combination to induce a better response. MATERIAL AND METHODS: We assessed the role of Ki67, hormone receptors expression, HER2, MYC genes and their protein status, and KRAS codon 12 mutations as predictor factors of pathologic response to anthracycline-cyclophosphamide (AC) followed by taxane docetaxel (T) neoadjuvant chemotherapy (AC+T regimen) in 51 patients with invasive ductal breast cancer...
December 24, 2016: Clinical Breast Cancer
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