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Clinical & Experimental Ophthalmology

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https://www.readbyqxmd.com/read/28032398/cultivation-and-characterisation-of-the-surface-markers-and-carbohydrate-profile-of-human-corneal-endothelial-cells
#1
Richárd Nagymihály, Zoltán Veréb, Réka Albert, Laura Sidney, Harminder Dua, Andrew Hopkinson, Goran Petrovski
BACKGROUND: To characterise human corneal endothelial cell (HCEnC) cultures generated by the peel-and-digest method based on their surface protein/carbohydrate expression pattern. METHODS: QPCR was used to compare expression of Vimentin, CD90, Cytokeratin-19, ZO-1, Claudin 14 in cultured HCEnC and cell line B4G12 versus stromal cells. Fluorescence-activated cell sorting (FACS) was used to assess surface protein distribution of cultured and uncultured HCEnC. Distribution of surface proteins/ carbohydrates was visualised by immunofluorescent and lectin staining...
December 29, 2016: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28013528/pathogens-and-antibiotic-sensitivities-in-endophthalmitis
#2
Geraldine R Slean, Neal H Shorstein, Liyan Liu, John F Paschal, Kevin L Winthrop, Lisa J Herrinton
BACKGROUND: Antibiotic prophylaxis in cataract surgery is intended to minimize endophthalmitis. We describe pathogenic organisms, antibiotic sensitivities, and antibiotic prophylaxis in culture-proven endophthalmitis cases. DESIGN: Retrospective consecutive case series, community-based setting. SAMPLES: 215 cases of endophthalmitis after cataract surgery performed during 2007-2012 in Kaiser Permanente, California. METHODS AND MAIN OUTCOME MEASURES: Descriptive analysis of isolated organisms and antibiotic sensitivities in relation to antibiotic prophylaxis in culture-proven endophthalmitis cases...
December 25, 2016: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28013525/interaction-of-primary-human-trabecular-meshwork-cells-with-metal-alloy-candidates-for-micro-invasive-glaucoma-surgery
#3
Wan Wendy Wang, Kelsey A Watson, S Jeffrey Dixon, Hong Liu, Amin Rizkalla, Cindy Ml Hutnik
BACKGROUND: Microinvasive glaucoma surgery (MIGS) is a relatively new addition to the glaucoma treatment paradigm. Small metallic stents are inserted into the trabecular meshwork in order to increase aqueous humour drainage. MIGS procedures are rapidly being adopted due to a more favourable side effect profile when compared to traditional surgery. Remarkably, this rapid rate of utilization has occurred without any published studies on the effect of metal alloys used in these stents on human trabecular meshwork cells (HTMCs)...
December 25, 2016: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28009474/prostaglandin-use-is-associated-with-increased-vascular-endothelial-growth-factor-in-the-aqueous-humor-of-glaucoma-patients
#4
LETTER
Jin-Woo Kwon, Donghyun Jee
No abstract text is available yet for this article.
December 23, 2016: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28002880/beware-the-tiger-x-s-stripes-two-cases-of-rapid-cataract-formation-in-patients-taking-rociletinib
#5
LETTER
Anupam Ca Rao, Karen Tiuseco, Steven Yun, Andrew White
No abstract text is available yet for this article.
December 21, 2016: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28002873/effects-of-pupil-dilation-on-maia-microperimetry
#6
Ruofan C Han, Jasleen K Jolly, Kanmin Xue, Robert E MacLaren
BACKGROUND: MAIA microperimetry assesses macular sensitivity to projected point light sources and maps eye movements to assess fixation stability. While microperimetry is gaining prominence as an assessment tool in clinical and research settings, there is no consensus on whether it should be performed before or after pupil dilation. No studies to date have examined the effect of pupil dilation on results. The aim of this project was to elucidate the effect of pupil dilation on microperimetry outcomes...
December 21, 2016: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28002872/lutein-facilitates-physiological-revascularization-in-a-mouse-model-of-retinopathy-of-prematurity
#7
Zhongjie Fu, Steven S Meng, Samuel B Burnim, Lois Eh Smith, Amy Cy Lo
BACKGROUND: Retinopathy of prematurity is one of the leading causes of childhood blindness worldwide, with vessel growth cessation and vessel loss in phase I followed by neovascularization in phase II. Ischemia contributes to its pathogenesis and lutein protects against ischemia-induced retinal damages. We aimed to investigate the effects of lutein on a murine model of oxygen-induced retinopathy. METHODS: Mouse pups were exposed to 75% oxygen for five days and returned to room air for another five days...
December 21, 2016: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/27990744/-en-face-ex-vivo-reflectance-confocal-microscopy-to-help-the-surgery-of-basal-cell-carcinoma-of-the-eyelid
#8
Marine Espinasse, Elisa Cinotti, Damien Grivet, Bruno Labeille, Virginie Prade, Catherine Douchet, Frédéric Cambazard, Gilles Thuret, Philippe Gain, Jean Luc Perrot
BACKGROUND: Fluorescence confocal microscopy (FCM) is a recent imaging technique for the examination of surgical cutaneous specimens and has been suggested as a fast alternative to Mohs micrographic surgery. Up-to-date it has been used in the fluorescence mode and with vertical sections of the specimen margins. The aim of this study was to evaluate FCM in the reflectance mode and with a horizontal ("en face") scanning of the surgical specimen in a series of basal cell carcinoma (BCC) of the eyelid...
December 19, 2016: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/27990740/hypertensive-eye-disease-a-review
#9
REVIEW
Samantha Fraser-Bell, Richard Symes, Anagha Vaze
Hypertension is a risk factor for a number of vision-threatening eye conditions including retinal vascular occlusion, retinal macroaneurysm and non arteritic anterior ischaemic optic neuropathy. In addition, hypertension may exacerbate the vision-threatening effects of diabetic retinopathy and has been implicated in the pathogenesis of age-related macular degeneration. The effects of sustained hypertension are directly visible in the eye as hypertensive retinopathy and choroidopathy, reflecting a pathological process occurring throughout the body...
December 19, 2016: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/27976518/classification-of-needling-for-trabeculectomy-blebs
#10
LETTER
Anthony King
No abstract text is available yet for this article.
December 15, 2016: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/27958676/refinement-of-needling-classification-for-trabeculectomy-blebs
#11
LETTER
Hamish P Dunn, Paul R Healey, Linda Zheng, Andrew Jr White
No abstract text is available yet for this article.
December 13, 2016: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/27957797/increased-corneal-subbasal-nerve-density-in-patients-with-sj%C3%A3-gren-syndrome-treated-with-topical-cyclosporine-a
#12
Ora Levy, Antoine Labbé, Vincent Borderie, Taous Hamiche, Bénédicte Dupas, Laurent Laroche, Christophe Baudouin, Nacim Bouheraoua
BACKGROUND: To evaluate quantitative and qualitative changes in subbasal corneal nerves (SBN) via in vivo confocal microscopy (IVCM) in patients with Sjögren syndrome dry eye (SSDE) treated with topical cyclosporine A (CsA). DESIGN: Prospective, observational, non-randomized study. PARTICIPANTS: Thirty eyes of 30 patients with SSDE refractory to conventional treatment treated with CsA 0.05% twice daily for six months. Fifteen eyes of 15 healthy, age and gender matched, volunteers constituted the control group at baseline...
December 13, 2016: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/27943526/kingella-kingae-microbial-keratitis-in-a-hiv-patient-with-orthokeratology-lens-wear
#13
LETTER
Harry Yip, Mark Whiting
No abstract text is available yet for this article.
December 12, 2016: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/27931076/sampling-methodology-and-site-selection-in-the-national-eye-health-survey-nehs-an-australian-population-based-prevalence-study
#14
Joshua Foreman, Stuart Keel, Ross Dunn, Peter van Wijngaarden, Hugh R Taylor, Mohamed Dirani
BACKGROUND: To present the sampling methodology and selected testing sites of the National Eye Health Survey (NEHS); a cross-sectional population-based survey that aimed to determine the prevalence of vision impairment and blindness in Australia. DESIGN: Indigenous Australians aged 40 years and older and non-Indigenous Australians aged 50 years and older residing in all levels of geographic remoteness in Australia. METHODS: Using multi-stage, random-cluster sampling, 30 geographic areas were selected to provide a sample of 3000 non-Indigenous Australians and 1400 Indigenous Australians...
December 8, 2016: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/27928901/calculating-resistance-in-the-lacrimal-system
#15
LETTER
Albert Wu, James Griggs, Dinesh Selva
No abstract text is available yet for this article.
December 8, 2016: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/27928879/minimally-invasive-glaucoma-surgery-as-primary-stand-alone-surgery-for-glaucoma
#16
REVIEW
Nathan M Kerr, Jing Wang, Keith Barton
Recently many new devices and procedures have been developed to lower intraocular pressure in a less invasive and purportedly safer manner than traditional glaucoma surgery. These new devices might encourage an earlier transition to surgery and reduce the long term commitment to topical glaucoma medications with their associated compliance and intolerance issues. While often seen as an adjunct to cataract surgery, a growing body of evidence suggests that primary MIGS may be a viable initial treatment option...
December 8, 2016: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/27928872/functional-visual-acuity-measurement-in-glaucoma
#17
LETTER
Haruka Sato, Hiroshi Kunikata, Junko Ouchi, Toru Nakazawa
No abstract text is available yet for this article.
December 8, 2016: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/27928888/self-care-tools-to-treat-depressive-symptoms-in-patients-with-age-related-eye-disease-a-randomized-controlled-clinical-trial
#18
Hortence Kamga, Jane McCusker, Mark Yaffe, Maida Sewitch, Tamara Sussman, Erin Strumpf, Sébastien Olivier, Walter Wittich, Solmaz Moghadaszadeh, Ellen E Freeman
BACKGROUND: Depression is very common in people with age-related eye disease. Our goal was to determine if self-care tools plus limited telephone support could reduce depressive symptoms in patients with age-related macular degeneration (AMD) or diabetic retinopathy (DR). DESIGN: A single-blind randomized controlled clinical trial was conducted at Maisonneuve-Rosemont Hospital in Montreal, Canada. PARTICIPANTS: Eighty participants were recruited METHODS: To be eligible, participants must have had either late stage AMD or DR, at least mild depressive symptoms, and visual acuity better than 20/200...
December 7, 2016: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/27928876/increased-levels-of-alphab-crystallin-in-vitreous-fluid-of-patients-with-proliferative-diabetic-retinopathy-and-correlation-with-vascular-endothelial-growth-factor
#19
Wei Chen, Qianyi Lu, Li Lu, Huaijin Guan
BACKGROUND: AlphaB-crystallin has been shown to have angiogenic properties. The purpose of this study was to determine the levels of alphaB-crystallin in the vitreous fluid of patients with proliferative diabetic retinopathy (PDR) and to confirm the association between the expression level of alphaB-crystallin and vascular endothelial growth factor (VEGF). METHODS: Vitreous samples were collected before vitrectomy from 46 eyes of 46 consecutive patients with PDR and 19 patients without diabetes mellitus (DM) had vitrectomy for idiopathic macular hole (IMH)...
December 7, 2016: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/27925385/communication-in-the-multidisciplinary-care-of-diabetic-eye-disease
#20
LETTER
Eddy J Tabet, Maria I Constantino, Jencia Wong, Dennis Yue
No abstract text is available yet for this article.
December 7, 2016: Clinical & Experimental Ophthalmology
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