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Clinical & Experimental Ophthalmology

Andre Ma, Martin Sy Mak, Kendrick Co Shih, Claudia Ky Tsui, Rachel Ky Cheung, Sherman Haynam Lee, Hubert Leung, Joyce Ns Leung, Jason Th Leung, Marco Zhenji Van-Boswell, Michael Tl Wong, Alex Lap-Ki Ng, Chi-Ho Lee, Vishal Jhanji, Louis Tong
Importance Diabetes mellitus is known to be associated with dry eye syndrome (DES), but the effects of long term glycaemic control on tear film metrics and dry eye symptoms are not known in the Chinese population. BACKGROUND: To evaluate tear film stability and dry eye symptoms and their associations with systemic risk factors in Chinese patients with type 2 diabetes (T2DM) Design Cross-sectional study set at the Lo Fong Siu Po Eye Centre (Grantham Hospital), Hong Kong.
January 18, 2018: Clinical & Experimental Ophthalmology
Vijay P Zawar, Swati V Zawar, Manoj K Pawar, Parikshit Gogate
Wood's lamp was invented by a Baltimore physicist, Robert W. Wood in 1903. It was first used by Margarot and Deveze in dermatology for the detection of fungal hair infection 1925.
January 11, 2018: Clinical & Experimental Ophthalmology
Huw E Oliphant, Saul Rajak
Punctal prolapse is an exceedingly rare clinical finding, and is yet to be described in English language literature. Conceivable pathogeneses are likely to be traumatic, infective or iatrogenic.
January 11, 2018: Clinical & Experimental Ophthalmology
Michael Tm Wang, Thomas L Kersey, Brian H Sloan, Jennifer P Craig
The modified Hughes tarsoconjunctival flap is widely used for posterior lamella repair during full thickness lower eyelid reconstruction, following tumour excision or trauma.1-3 The flap bisects the meibomian glands in the upper tarsal plate and places the donor flap into the lower eyelid defect.1,2 However, the effects of this procedure on tear film function have not yet been fully established.1-3.
January 8, 2018: Clinical & Experimental Ophthalmology
Sukhpal S Sandhu, Lyndell Lp Lim
No abstract text is available yet for this article.
January 3, 2018: Clinical & Experimental Ophthalmology
Anna Cs Tan, Ryan Man, Chee Wai Wong, Shu Yen Lee, Ecosse L Lamoureux, Marcus Ang
IMPORTANCE: The novel intervention was effective at improving compliance to appropriate tertiary eye-care after community eye screening. BACKGROUND: Elderly individuals from low socioeconomic background with visual impairment (VI) often do not attend tertiary care, even if significant eye diseases are detected while in the community. We evaluate a novel incentive-care scheme (ICS) to improve compliance to appropriate follow-up after community eye screening. DESIGN: Randomised controlled trial in a population-based setting...
December 28, 2017: Clinical & Experimental Ophthalmology
Huw Oliphant, Mark Taylor, Saul Rajak
Cutaneous pleomorphic rhabdomyosarcoma is a rare malignant mesenchymal tumour which can affect all age ranges, though subcutaneous forms of this disease are uncommonly described. We present a case of a 77 year old lady with a rapidly growing periocular lesion subsequently demonstrated on histopathological and immunohistochemical examination to be a pleomorphic rhabdomyosarcoma. No orbital involvement was demonstrated and no distant metastases were evident.
December 28, 2017: Clinical & Experimental Ophthalmology
Geoffrey Chan, William H Morgan, Dao-Yi Yu, Chandrakumar Balaratnasingam
Optic nerve head (ONH) drusen is a condition of unresolved aetiology with an incidence of approximately 3.4 per 1000 in the general population.1 Presumably, similar to glaucoma, the predominant site of retinal ganglion cell (RGC) axonal injury due to disc drusen occurs at the ONH, where laminated, calcified aggregates of hyaline-like material are found.1 A large number of studies have delineated the complex pathophysiologic pathways underlying glaucomatous optic neuropathy and have demonstrated alterations to all 4 compartments of the RGC; namely the dendritic arborisations, cell body, unmyelinated portion of the RGC axon and myelinated portion of the RGC axon...
December 27, 2017: Clinical & Experimental Ophthalmology
Jonathan S Myers, Scott J Fudemberg, Daniel Lee
Visual evaluation of the optic nerve has been one of the earliest and most widely used methods to evaluate patients for glaucoma. Photography has proven very useful for documentation of the nerve's appearance at a given time, allowing more detailed scrutiny then, and later comparison for change. Photography serves as the basis for real time or non-simultaneous review in telemedicine and screening events allowing fundus and optic nerve evaluation by experts elsewhere. Expert evaluation of disc photographs has shown diagnostic performance similar to other methods of optic nerve evaluation for glaucoma...
December 27, 2017: Clinical & Experimental Ophthalmology
Chia-Chieh Hsiao, Ming Yao, Jia-Hau Liu, Wei-Li Chen
Recently immunotherapy has made considerable progress in cancer treatment. Pembrolizumab is a humanized monoclonal antibody against immune checkpoint programmed death 1 (PD-1) receptor that is approved for the treatment of unresectable or metastatic melanoma and lung cancer 1,2 .
December 27, 2017: Clinical & Experimental Ophthalmology
Rachel Fan, Tommy Cy Chan, Gaurav Prakash, Vishal Jhanji
Corneal imaging is essential for diagnosing and management of a wide variety of ocular diseases. Corneal topography is used to characterize the shape of the cornea, specifically, the anterior surface of the cornea. Most corneal topographical systems are based on Placido disc that analyze rings that are reflected off the corneal surface. The posterior corneal surface cannot be characterized using Placido disc technology. Imaging of the posterior corneal surface is useful for diagnosis of corneal ectasia. Unlike corneal topographers, tomographers generate a three-dimensional recreation of the anterior segment and provide information about the corneal thickness...
December 20, 2017: Clinical & Experimental Ophthalmology
Syed Amal Hussnain, Kyle D Kovacs, Joshua L Warren, Christopher C Teng
IMPORTANCE: Corneal hysteresis (CH) is a dynamic marker of structural and functional changes in the cornea associated with IOP and central corneal thickness, but its utility in assessing primary angle closure suspects (PACS) has not been fully elucidated. BACKGROUND: This study assesses if anterior segment measurements correlate with CH in PACS patients. DESIGN: IRB-approved retrospective review of imaging and records at a university practice...
December 18, 2017: Clinical & Experimental Ophthalmology
Matthew McCartney, Luke Chehade, Paul McCartney
For the patient with significant intractable diplopia, unresponsive to strabismus surgery or prismatic correction, management options are limited and usually involve occlusion. Implantation of pupil-occlusive intraocular lenses (POIL) offers a cosmetically pleasing solution1-2 .Photophobia, image delay, leukocoria and intractable diplopia all represent potential indications for occlusion, and can arise from traumatic eye injury causing extraocular muscle nerve palsies, vision loss, meningioma, juvenile cataract and Coates' disease1-2 ...
December 18, 2017: Clinical & Experimental Ophthalmology
Ellen F Wang, Andrew Worsley, Philip J Polkinghorne
IMPORTANCE: To compare the safety and outcomes of femtosecond laser assisted cataract surgery and conventional phacoemulsification in post-vitrectomy eyes. BACKGROUND: To compare visual outcomes and adverse outcomes of femtosecond laser assisted cataract surgery and conventional phacoemulsification in vitrectomised eyes. DESIGN: Single surgeon, retrospective study set in a private clinic in Auckland, New Zealand. Patients selected in a chronological manner, without masking or randomisation...
December 14, 2017: Clinical & Experimental Ophthalmology
Chi Yun Doreen Ho, Jia Jia Lek, Khin Zaw Aung, Myra B McGuinness, Chi D Luu, Robyn H Guymer
IMPORTANCE: Reticular pseudodrusen (RPD) is strongly associated with late age-related macular degeneration (AMD) but their etiology remains unknown. RPD have been associated with reduced choroidal thickness but most studies are limited by small sample size and varying severity of AMD. BACKGROUND: To investigate the relationship between choroidal thickness (ChT) and RPD in eyes with intermediate AMD (iAMD), controlling for variables known to influence ChT. DESIGN: Retrospective cohort study PARTICIPANTS: Participants were recruited from Centre for Eye Research Australia...
December 13, 2017: Clinical & Experimental Ophthalmology
Andrzej Grzybowski, Piotr Kanclerz
We have read the article by Walsh et al.1 with interest, however, we believe some issues should be clarified. The authors present a database study evaluating records of 4,942 patients who underwent cataract surgery, particularly regarding antibiotic prophylaxis.
December 13, 2017: Clinical & Experimental Ophthalmology
Jeffrey F Scott, Ritva Vyas, Jessica Galvin, Erica Gotow, Lori Fiessinger, Adam T Gerstenblith, Meg R Gerstenblith
IMPORTANCE: Primary bilateral uveal melanoma is a rare and incompletely described entity. It is not known how these patients compare to those with unilateral uveal melanoma. BACKGROUND: We sought to comprehensively characterize and compare patients with primary bilateral and unilateral uveal melanoma. DESIGN: Retrospective, population-based and systematic review. PARTICIPANTS: Patients with bilateral (N=52) and unilateral uveal melanoma (N=8915)...
December 8, 2017: Clinical & Experimental Ophthalmology
Luke Halliday, Paul Ikgan Sia, Shane Durkin, Dinesh Selva
Acute orbital inflammation due to hyaluronidase allergy is a rare complication of regional eye anaesthesia.1, 2 It commonly presents as pain, proptosis, periorbital oedema and restricted extraocular movements.3 We report an atypical case of hyaluronidase allergy that had resulted in profound visual loss.
December 8, 2017: Clinical & Experimental Ophthalmology
Lanhua Wang, Yanzhi Zhao, Xiaotong Han, Wenyong Huang, Guofu Huang, Mingguang He
IMPORTANCE: Longitudinal data on visual outcome of correctable visual impairments (VI) are of paramount importance for decision-maker to estimate burden and demand to treat avoidable VI. BACKGROUND: To assess the 5-year visual outcome among participants with correctable VI and to identify associated risk factors. DESIGN: Population-based longitudinal cohort study. PARTICIPANTS: Participants with correctable VI at baseline attended the 5-year follow-up visit of the Liwan Eye Study...
December 7, 2017: Clinical & Experimental Ophthalmology
Emil D Kurniawan, John R Rocke, Sukhpal S Sandhu, Penelope J Allen
We thank Grzybowski and Turczynowska (1) for their interest in our recent publication (2). The Endophthalmitis Vitrectomy Study (EVS) (3) is now over two decades old, and the criterion of early vitrectomy within six hours was strictly adhered to as part of this prospective, limited-time study. Our retrospective study exposes the limitations of such a strict criterion, even in the setting of a quaternary specialist eye hospital.
December 7, 2017: Clinical & Experimental Ophthalmology
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