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Clinical & Experimental Ophthalmology

Chee Foong Chong, Charles Nj McGhee, Shuan H Dai
IMPORTANCE: This is the first national study on childhood visual impairment in a developed nation, New Zealand; describing prevalence, aetiology and preventable causes of low vision and blindness in children. BACKGROUND: Causes of childhood blindness varies between regions. This study aimed to present region-specific data on epidemiology of childhood blindness affecting a developed nation, New Zealand. DESIGN: Retrospective data analysis PARTICIPANTS: All children enrolled with the Blind and Low Vision Education Network (BLENNZ) with best corrected visual acuity =<6/18, or binocular visual field <10 degrees...
November 14, 2018: Clinical & Experimental Ophthalmology
Abhishek Sharma, Asim Ali, Robert H Henderson, C K Patel, Cynthia VandenHoven, Wai-Ching Lam
IMPORTANCE: There is variation in the literature for sclerotomy and intravitreal injection placement in young children, ranging from 0.5-3.0mm from the limbus. We assess the accuracy of scleral transillumination to identify the ciliary body in infants for safe sclerotomy and intravitreal injections in young children. BACKGROUND: The study compares the perilimbal 'dark band' seen on scleral transillumination (STI) with the Ultrasound Biomicroscopy (UBM), and compares these measurements with the current guidelines for sclerotomy in infants...
November 12, 2018: Clinical & Experimental Ophthalmology
Tess G Ryan, David S Curragh, Dinesh Selva
No abstract text is available yet for this article.
November 11, 2018: Clinical & Experimental Ophthalmology
Jennifer H Court, Lucy M Lu, Nancy Wang, Charles Nj McGhee
IMPORTANCE: Open globe injuries (OGI) are a leading cause of monocular blindness world-wide with considerable cost to the individual and society. BACKGROUND: To characterize the epidemiology, severity and outcomes of OGI treated at a major ophthalmology centre in New Zealand. DESIGN: Retrospective study. PARTICIPANTS: A total of 385 eyes of 381 patients over a ten year period. METHODS: Eligible patients were identified using diagnosis and surgery codes on hospital discharge summaries...
November 9, 2018: Clinical & Experimental Ophthalmology
Guojun Cao, Chen Tan, Yuyan Zhang, Xiangmei Kong, Xinhuai Sun, Yanchun Ma, Junyi Chen, Ming Guan
BACKGROUND: To compare the detection results consistency of quantitative polymerase chain reaction (qPCR) and digital droplet polymerase chain reaction (ddPCR), and determine the value of ddPCR for viral detection in the aqueous humour. METHODS: A total of 130 aqueous humour samples were collected, including 60 patients with PSS in case group and 70 elderly patients with senile cataract in control group. The target nucleic acid fragments of HCMV, HSV, EBV and VZV in aqueous humour were analyzed by qPCR and ddPCR respectively, for the diagnosis and curative effect monitoring of pathogen-induced PSS...
November 9, 2018: Clinical & Experimental Ophthalmology
Jiwon Baek, Jae Hyung Lee, Byung-Joo Chung, Kook Lee, Won Ki Lee
IMPORTANCE: To reveal choroidal morphological profiles under pachydrusen. BACKGROUND: Drusen in pachychoroid disorders show certain differences from conventional drusen and are recently named as 'pachydrusen'. This study analyzed the specific choroidal morphology under pachydrusen. DESIGN: This study is a cross-sectional case series. PARTICIPANTS: Enrolled were 136 eyes with pachydrusen from 134 patients. METHODS: The presence of pachydrusen in fundus area covered by a 12x9 mm2 optical coherence tomography (OCT) image was accessed in eyes with pachychoroid-related diseases or their fellow eyes using colour fundus photography and swept source OCT...
November 4, 2018: Clinical & Experimental Ophthalmology
Aparna Murali, Charmaine A Ramlogan-Steel, Slawomir Andrzejewski, Jason C Steel, Christopher J Layton
The retina is the tissue responsible for light detection, in which retinal neurons convert light energy into electrical signals to be transported towards the visual cortex. Damage of retinal neurons leads to neuronal cell death and retinal pathologies, compromising visual acuity and eventually leading to irreversible blindness. Models of retinal neurodegeneration include 2D systems like cell lines, disassociated cultures and co-cultures, and 3D models like organoids, organotypic retinal cultures and animal models...
October 30, 2018: Clinical & Experimental Ophthalmology
Clark H Stevenson, Sheng Chiong Hong, Kelechi C Ogbuehi
IMPORTANCE: Artificial intelligence (AI) algorithms are under development for use in diabetic retinopathy photo screening pathways. To be clinically acceptable, such systems must also be able to classify other fundus abnormalities and clinical features at the point of care. BACKGROUND: We aimed to develop an AI system that can detect several fundus pathologies and report relevant clinical features. DESIGN: Convolutional neural network training with retrospective data set...
October 29, 2018: Clinical & Experimental Ophthalmology
Jack Ao, Swati Singh, David S Curragh, Rowan Valentine, Dinesh Selva
No abstract is available for this article. This article is protected by copyright. All rights reserved.
October 28, 2018: Clinical & Experimental Ophthalmology
Xiaotong Han, Chimei Liao, Chi Liu, Pei Ying Lee, Jian Zhang, Stuart Keel, Mingguang He
IMPORTANCE: Data on the incidence of presenting vision impairment (PVI) and spectacle coverage rate (SCR) in urban China is limited. BACKGROUND: To estimate the 6-year incidence and risk factors for PVI and the SCR in urban Southern China. DESIGN: Population-based cohort study. PARTICIPANTS: 1817 participants aged ≥35 years were identified from Guangzhou in 2008 for baseline and 1427 attended follow-up examination in 2014...
October 26, 2018: Clinical & Experimental Ophthalmology
William Yan, Wei Wang, Peter van Wijngaarden, Andreas Mueller, Mingguang He
IMPORTANCE: Cataract is the leading cause of blindness and the second leading cause of vision impairment. The majority of people with vision impairment reside in low-resource settings with limited access to cataract surgery and services. BACKGROUND: Cataract surgery rate (CSR) is a proxy measure for eye care service delivery and estimating the burden of cataract disease. This research aims to evaluate the longitudinal changes of CSR inequality globally and by income groups...
October 26, 2018: Clinical & Experimental Ophthalmology
Morgan S Kennedy, James Robinson, Eline Whist, Gabrielle B McCallum, Tharmalingam Mahendrarajah
IMPORTANCE: Epidemiological data on visually significant ocular trauma in the Top End of the Northern Territory. BACKGROUND: Our main objective is to determine whether Indigenous patients are disproportionately affected by visually significant ocular trauma as compared to non-Indigenous patients. DESIGN: This was a retrospective audit at the Royal Darwin Hospital (RDH) in the Top End of the Northern Territory during January 2013 - June 2015...
October 26, 2018: Clinical & Experimental Ophthalmology
Luke K Chehade, David Curragh, Dinesh Selva
No abstract text is available yet for this article.
October 25, 2018: Clinical & Experimental Ophthalmology
Alicia Muñoz-Gallego, Javier De la Cruz, Martín Rodríguez-Salgado, José L Torres-Peña, Javier Sambricio, Ana Ortueta-Olartecoechea, Pilar Tejada-Palacios
IMPORTANCE: Optical coherence tomography software classifies abnormality of macular ganglion cell-inner plexiform layer thickness and macular retinal nerve fibre layer thickness based on adult series. BACKGROUND: We assessed the impact of using paediatric reference macular ganglion cell complex values instead of adult reference values. DESIGN: Cross-sectional study. Primary and tertiary health-care setting. PARTICIPANTS: Out of 140 healthy participants aged 5 to 18 years, 90% were eligible...
October 24, 2018: Clinical & Experimental Ophthalmology
Lam Nguyen Hoang, Peter J McCluskey, John R Grigg, Anne J Lee
No abstract text is available yet for this article.
October 23, 2018: Clinical & Experimental Ophthalmology
Marko Popovic, Shakeel Shareef, Juan J Mura, Felipe Valenzuela, Julio González Martín-Moro, Matthew B Schlenker, Keith Barton, Francisco Muñoz-Negrete, M Reza Razeghinejad, Iqbal Ike K Ahmed
No abstract is available for this article. This article is protected by copyright. All rights reserved.
October 23, 2018: Clinical & Experimental Ophthalmology
Calvin S Fong, Saul N Rajak, Akihide Watanabe, Dinesh Selva
No abstract text is available yet for this article.
October 22, 2018: Clinical & Experimental Ophthalmology
Cameron A McLintock, James McKelvie, Zisis Gatzioufas, Samer Hamada
No abstract text is available yet for this article.
October 21, 2018: Clinical & Experimental Ophthalmology
Gareth Lingham, Alex Burton, Holly A Brown, Emily Huynh, Seyhan Yazar, Minas T Coroneo, David A Mackey
IMPORTANCE: Excessive ocular sun exposure is linked to various eye pathologies. Conjunctival ultraviolet autofluorescence (CUVAF) is a method of detecting sun-related conjunctival damage; however, the custom-built camera system required is not readily available. BACKGROUND: We investigate whether blue laser autofluorescence (BAF) on a commonly used confocal scanning laser ophthalmoscope (cSLO) can be utilised to measure CUVAF area. DESIGN: Cross-Sectional evaluation of a diagnostic technology at a medical research institute...
October 21, 2018: Clinical & Experimental Ophthalmology
Charmaine A Ramlogan-Steel, Aparna Murali, Slawomir Andrzejewski, Bijay Dhungel, Jason C Steel, Christopher J Layton
Voretigene neparvovec-rzyl was recently approved for the treatment of Leber Congenital Amaurosis, and the use of gene therapy for eye disease is attracting even greater interest. The eye has immune privileged status, is easily accessible, requires a reduced dosage of therapy due to its size, and is highly compartmentalized, significantly reducing systemic spread. Adeno-associated virus (AAV), with its low pathogenicity, prolonged expression profile and ability to transduce multiple cell types, has become the leading gene therapy vector...
October 21, 2018: Clinical & Experimental Ophthalmology
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