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Clinical & Experimental Ophthalmology

Fiona C Pearce, Ravi Thomas, Nathan Jy Wong, Mark J Walland
Laser peripheral iridotomy (LPI) can prevent acute attacks and open the angle in primary angle closure suspects (PACS), yet up to 35% percent of patients have a 'closed angle' after LPI.(1) Are only these eyes at risk of progression?
March 2, 2018: Clinical & Experimental Ophthalmology
Stuart Keel, Jing Xie, Joshua Foreman, Hugh R Taylor, Mohamed Dirani
IMPORTANCE: Choroidal nevi are a common incidental finding on fundus examination. The National Eye Health Survey (NEHS, 2015-16) provides an up-to-date estimate of the prevalence of choroidal nevi in non-Indigenous and Indigenous Australian adults. BACKGROUND: To describe the prevalence and characteristics of choroidal nevi amongst non-Indigenous and Indigenous Australian adults. DESIGN: Population-based cross-sectional study PARTICIPANTS: This study included 3098 non-Indigenous Australians (aged 50-98 years) and 1738 Indigenous Australians (aged 40-92 years) living in 30 randomly selected sites, stratified by remoteness...
March 2, 2018: Clinical & Experimental Ophthalmology
Rong-Mei Peng, Yu-Xin Guo, Yuan Qiu, Jing Hong, Ge-Ge Xiao, Hong-Qiang Qu
IMPORTANCE: There is limited literature on paediatric donors in endothelial keratoplasty. BACKGROUND: This study investigated the efficacy of and appropriate paediatric donor age for Descemet's stripping endothelial keratoplasty (DSEK). DESIGN: Retrospective, observational case series. PARTICIPANTS: Thirty-eight consecutive patients underwent DSEK with paediatric donor corneas. METHODS: The age of the donors ranged from 32 weeks gestation (premature neonate) to 3 years old...
March 2, 2018: Clinical & Experimental Ophthalmology
Jessie Huang, Michael P Hennessy, Michael Kalloniatis, Barbara Zangerl
Due to a growing and ageing population, the number of Australians living with chronic eye conditions such as glaucoma and ocular hypertension is projected to increase.1 The current unmet demand for public hospital ophthalmology appointments have caused waiting periods for routine, non-urgent referrals to often exceed 12 months.2 .
March 2, 2018: Clinical & Experimental Ophthalmology
Qiwei Wang, Wu Jiang, Tiao Lin, Yi Zhu, Chuan Chen, Haotian Lin, Weirong Chen
IMPORTANCE: Visual outcome after intraocular lens (IOL) implantation in long eyes is considerably affected by IOL power calculation. Various formulas have been designed to achieve an accurate IOL power prediction. However, controversy about the accuracy remains. BACKGROUND: To evaluate the accuracy of IOL power calculation formulas in long eyes. DESIGN: Meta-analysis PARTICIPANTS: Patients with ocular axial length (AL) over 24.5 mm. METHODS: A comprehensive search in PubMed, EMBASE, Cochrane Data Base of Systematic Reviews, and the Cochrane Central Register of Controlled Trials were conducted by September, 2017...
March 2, 2018: Clinical & Experimental Ophthalmology
Keith Ong, Grace Ang
The opacified posterior capsule after cataract phacoemulsification and posterior chamber intraocular lens insertion compromises light transmission onto the retina. Creating a central opening with YAG laser posterior capsulotomy improves visual acuity. Finding the ideal laser posterior capsulotomy size would be useful.
February 21, 2018: Clinical & Experimental Ophthalmology
Alina Y Yang, James Kempton, Ji Liu
Laser peripheral iridotomy (LPI) is the standard treatment for angle-closure glaucoma and eyes at risk for this condition, such as those with occludable narrow angles. While generally considered a safe and routine procedure in the clinic, it is not without risk.
February 21, 2018: Clinical & Experimental Ophthalmology
Kelvin H Wan, Tommy Cy Chan, Marco Yu, Vishal Jhanji
LASIK intends to decrease the corneal power by increasing the radius of corneal curvature in myopic correction. Though it does not directly affect the posterior corneal surface, modification is not unexpected since LASIK can weaken the cornea especially in high myopic correction.
February 21, 2018: Clinical & Experimental Ophthalmology
Sidra Zafar, Rehman Siddiqui
Retinal astrocytomas are low-grade neoplasms, typically of non-aggressive nature. Tumor characteristics may vary greatly and they most often occur in association with tuberous sclerosis. Less commonly, astrocytomas may occur with neurofibromatosis or they may be sporadic1,2 .
February 21, 2018: Clinical & Experimental Ophthalmology
Chi Yun Doreen Ho, Thomas G Hardy
Crocodile tear syndrome (CTS) is a rare symptom characterized by excessive unilateral tearing occurring with gustatory stimuli known to develop as a sequel of facial nerve involvement as evident by facial palsy on the affected side.(1) CTS may more rarely occur without antecedent facial palsy with only four cases described in English literature.(2).
February 14, 2018: Clinical & Experimental Ophthalmology
Kate E Leahy, Michele C Madigan, Maria Sarris, Stephanie L Watson, Peter McCluskey, Andrew Jr White
IMPORTANCE: Transient corneal endothelial changes are routinely noted on slit-lamp examination immediately following selective laser trabeculoplasty (SLT). BACKGROUND: To determine the mechanism of the transient corneal endothelial changes observed following SLT. DESIGN: University laboratory based observational study SAMPLES: Ten corneas from six human cadaveric donors. METHODS: Corneas were treated with SLT, direct laser, or peroxide, or used as controls...
February 14, 2018: Clinical & Experimental Ophthalmology
Anmar Abdul-Rahman
Clinical examination remains the gold standard in the diagnosis of a cyclodialysis cleft. This could be challenging especially in the presence of folds in Descemet's membrane, hyphema, corneal edema, peripheral anterior synechiae or a shallow anterior chamber.1 .
February 14, 2018: Clinical & Experimental Ophthalmology
Elisa J Campos, João Martins, Dan Brudzewsky, Sandra Correia, Ana R Santiago, David Pd Woldbye, António F Ambrósio
BACKGROUND: Neuropeptide Y (NPY) is a neuromodulator that is expressed in the retina. Increasing evidence suggests that NPY has pronounced anti-inflammatory effects, which might depend on the inhibition of dipeptidyl-peptidase-IV (DPP-IV). The aim of this study was to investigate the impact of type 1 diabetes mellitus (DM) and sitagliptin, a DPP-IV inhibitor, on the NPY system in the retina using an animal model. METHODS: Type 1 DM was induced in male Wistar rats by an intraperitoneal injection of streptozotocin (STZ)...
February 14, 2018: Clinical & Experimental Ophthalmology
Michelle Hui, Aparna Raniga, Samantha Fraser-Bell, Wedad Salem, Colin Clement
In developed countries, age-related macular degeneration (AMD) is a leading cause of visual impairment, particularly in its neovascular form.1 Intravitreal injection of anti-vascular endothelial growth factor (anti-VEGF) is the standard of care for wet AMD. Inspite of the small intravitreal bolus of 0.05ml, many studies have reported a rise in intraocular pressure (IOP) immediately post injection.1-3 .
February 14, 2018: Clinical & Experimental Ophthalmology
Shani Golan, Daniel B Rootman, Val Lambros, Robert A Goldberg
Thyroid eye disease (TED) is characterized in most cases by an expansion in the fat and/or muscle in the orbit (1). Being an enclosed and fixed space, such alterations would be presumed to result in changes to intra-orbital pressure (2) and in compliance of the orbit, leading to decreased retro-displacement of the orbit with supine positioning (3,4).
February 11, 2018: Clinical & Experimental Ophthalmology
Jonathan N Levenson, Kathleen A Regan, J Ruth Asirvatham, Siva Sr Iyer
A 57 year old African American woman presented with a six-month history of progressively worsening right-sided frontal headaches, nasal obstruction with epistaxis, cough, and vision loss of the right eye. She was treated for presumed sinusitis with antibiotics, steroid spray, and a decongestant without relief.
February 9, 2018: Clinical & Experimental Ophthalmology
Brett Drury, Leon Au
The XEN® 45 Gel Stent (Allergan, Dublin, Ireland) is a device for the treatment of glaucoma and is classified amongst the Micro Invasive Glaucoma Surgery (MIGS) devices. The device consists of a gelatin based tube, measuring 6mm in length with a 45µm internal diameter.
February 9, 2018: Clinical & Experimental Ophthalmology
Yu-Yi Lin, Jorn-Hon Liu, Yin Chang
BACKGROUND: To investigate and compare the cytotoxicity of indocyanine green (ICG), brilliant blue G (BBG) and trypan blue (TB) using ARPE-19 cells that have been pre-treated/post- treated with balanced salt solution (BSS) or fetal bovine serum (FBS). METHODS: The cultured human retina pigment epithelium (RPE) ARPE-19 cells were pre-treated/post-treated with BSS or FBS (represent the autologous serum in clinic) in parallel with cells being soaked with various concentrations of ICG, BBG, and TB...
February 8, 2018: Clinical & Experimental Ophthalmology
Jason Lange, Majda Hadziahmetovic, Jingfa Zhang, Weiye Li
IMPORTANCE: Region-specific pathology in proliferative diabetic retinopathy enhances our understanding and management of this disease. BACKGROUND: To investigate non-perfusion, neovascularization, and macular edema. DESIGN: A cross-sectional, observational, non-randomized study. PARTICIPANTS: Consecutive 43 eyes of 27 treatment-naïve patients. METHODS: Ultra-widefield fluorescein angiography for studying specific zones, i...
February 7, 2018: Clinical & Experimental Ophthalmology
James McKelvie, Moaz Alshiakhi, Mohammed Ziaei, Dipika V Patel, Charles Nj McGhee
IMPORTANCE: Acanthamoeba is an increasingly prevalent cause of vision-threatening microbial keratitis. BACKGROUND: To assess the incidence, clinical presentation, diagnosis and outcomes of patients with Acanthamoeba keratitis (AK) in Auckland, New Zealand over a 7-year period. DESIGN: Retrospective observational consecutive case series. PARTICIPANTS: Fifty-eight eyes of 52 patients diagnosed with AK. METHODS: All cases of AK were identified using a cross-referenced search of clinical, laboratory and pharmacy records from March 2009 to May 2016...
February 7, 2018: Clinical & Experimental Ophthalmology
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