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Clinical & Experimental Ophthalmology

Nicole Balducci, Maria Lucia Cascavilla, Antonio Ciardella, Chiara La Morgia, Giacinto Triolo, Vincenzo Parisi, Francesco Bandello, Alfredo A Sadun, Valerio Carelli, Piero Barboni
IMPORTANCE: The contribution of the microvascular supply to the pathogenesis of Leber's Hereditary Optic Neuropathy (LHON) is poorly understood. BACKGROUND: We aimed at measuring the peripapillary capillary vessel density (VD) using optical coherence tomography angiography (OCT-A) at different stages of LHON. DESIGN: Prospective, cross-sectional, multicenter, observational study. PARTICIPANTS: Twenty-two LHON patients divided in 4 groups: unaffected mutation carriers (LHON-u); early subacute stage (LHON-e); late subacute stage (LHON-l); chronic stage (LHON-ch)...
May 22, 2018: Clinical & Experimental Ophthalmology
James A Slater, Stuti L Misra, Geoffrey Braatvedt, Charles Nj McGhee
No abstract is available for this article. This article is protected by copyright. All rights reserved.
May 20, 2018: Clinical & Experimental Ophthalmology
Ivailo Zhekov, Shahina Pardhan, Rupert Ra Bourne
IMPORTANCE: The change in the anatomical dimensions over time and the effect on diurnal intraocular pressure (DIOP) following laser peripheral iridotomy is poorly understood. BACKGROUND: To evaluate change over time in anterior chamber angle anatomy following laser peripheral iridotomy (LPI) in patients with primary angle closure compared to control eyes. Additionally, the effect of LPI on DIOP fluctuation was investigated. DESIGN: Longitudinal, prospective, double-randomized research study...
May 16, 2018: Clinical & Experimental Ophthalmology
Maria Cabrera-Aguas, Dana Robaei, Peter McCluskey, Stephanie Watson
IMPORTANCE: Standardise initial anti-viral therapy for herpes simplex keratitis (HSK) BACKGROUND: To determine prescribing trends for the management of HSK and compare the trends to available clinical trial evidence. DESIGN: Retrospective review of patients at the Sydney Eye Hospital, Australia. PARTICIPANTS: Three hundred and one eyes of 296 patients prescribed anti-virals for HSK aged 18 years and above, from January 1, 2012 to December 31, 2013...
May 10, 2018: Clinical & Experimental Ophthalmology
Hiroaki Endo, Satoru Kase, Mitsuo Takahashi, Masahiko Yokoi, Chisato Isozaki, Satoshi Katsuta, Manabu Kase
IMPORTANCE: Choroidal thickness changes in diabetic retinopathy improve the understanding of the pathophysiology and managements of this disease. BACKGROUND: To examine the choroidal layer thickness in diabetes mellitus (DM) patients and normal individuals, and to compare the findings based on medical history of systemic DM treatments, and stage of diabetic retinopathy (DR). DESIGN: Case control study. PARTICIPANTS: Two hundred and sixty-eight eyes of 134 DM patients and age-matched 72 healthy controls of 92 eyes...
May 9, 2018: Clinical & Experimental Ophthalmology
Katia A Maccora, Emmanuelle Souzeau, Jonathan B Ruddle, Jamie E Craig
Hereditary hyperferritinaemia cataract syndrome (HHCS, OMIM 600886) is a rare autosomal dominant disorder characterised by early cataract formation and isolated high serum ferritin. Typical cataracts in HHCS are of a distinctive morphology characterised by progressive axial and peripheral white flecks with small crystalline aggregates1 .
May 8, 2018: Clinical & Experimental Ophthalmology
Shikha Gupta, Harathy Selvan, Surbhi Agrawal, Viney Gupta
Cyclodialysis is the detachment of the longitudinal ciliary body muscle from the scleral spur. Bypassing the angle, it directs the aqueous into the suprachoroidal space causing hypotony. Hence it is important that the cleft be identified and treated, especially when associated with complications such as hypotonic maculopathy.1 Small clefts may resolve spontaneously, however, most of them need some form of treatment, primarily decided based on the number, height and extent of the clefts.2 Hence, accurate estimation of the cleft dimensions is important...
May 7, 2018: Clinical & Experimental Ophthalmology
Chi Yd Ho, Jia J Lek, Khin Z Aung, Myra B McGuinness, Chi D Luu, Robyn H Guymer
We thank Invernizzi, Nguyen and Gillies1 for their interest in our paper "Relationship between reticular pseudodrusen and choroidal thickness in intermediate age-related macular degeneration".2 .
May 7, 2018: Clinical & Experimental Ophthalmology
Daniel T Hogarty, Deborah J Russell, Bernadette M Ward, Nicholas Dewhurst, Peter Burt
IMPORTANCE: This study is the first to compare the extended range of vision (ERV) intraocular lens (IOL) targeted at micro-monovision to a monofocal targeted at binocular emmetropia. BACKGROUND: Compares visual acuity, range of vision and spectacle independence in monofocal and ERV IOLs. DESIGN: Assessor-blinded retrospective cohort study. PARTICIPANTS: 88 participants (176 eyes) with bilateral IOL implants at 5+ month post-operative review...
May 3, 2018: Clinical & Experimental Ophthalmology
Mabel K Yan, John Sm Chang, Tommy Cy Chan
Uncorrected refractive errors are a leading cause of visual impairment across the world. In today's society, laser in-situ keratomileusis (LASIK) has become the most commonly performed surgical procedure to correct refractive errors. However, regression of the initially-achieved refractive correction has been a widely-observed phenomenon following LASIK since its inception more than two decades ago. Despite technological advances in laser refractive surgery and various proposed management strategies, post-LASIK regression is still frequently observed and has significant implications for the long-term visual performance and quality of life of patients...
April 26, 2018: Clinical & Experimental Ophthalmology
Mark Zada, Hamish Dunn, Andrew White
Argon laser peripheral iridoplasty (ALPI) is often used in patients with primary angle closure (PAC) and elevated intraocular pressure (IOP) following peripheral iridotomy. In these patients, factors other than pupillary block contribute to persistent angle closure such as plateau iris syndrome1 and ALPI has been proposed as a means to widen the angle recess by causing thinning and contraction of the peripheral iris.2 .
April 26, 2018: Clinical & Experimental Ophthalmology
Braden Young, Salim Okera
A healthy 62-year-old female presented with an atraumatic subconjunctival haemorrhage in her left eye. The patient had no previous ophthalmic history apart from recurrent subconjunctival haemorrhage in alternating eyes. She reported five previous episodes in her right eye and nine in the left over the course of 10 years. There were no identified precipitants to these episodes. There was a history of mitral valve regurgitation not requiring anticoagulation. There was no history of hypertension. She was a non-smoker and drank minimal alcohol...
April 26, 2018: Clinical & Experimental Ophthalmology
Justin C Sherwin, Gokulan Ratnarajan, Babar Elahi, Anna Bilkiewicz-Pawelec, John F Salmon
IMPORTANCE: Ocular surface disease (OSD) is common and can reduce treatment compliance and quality of life. BACKGROUND: To determine whether a punctal plug improves OSD and reduces IOP in patients using prostaglandin-analogue monotherapy. DESIGN: Randomised-controlled trial PARTICIPANTS: Sixty eligible subjects aged >18 years with symptomatic OSD from glaucoma clinics were invited to participate. Lacrimal or glaucoma surgery, lid malposition and contact lens wear were exclusion criteria...
April 26, 2018: Clinical & Experimental Ophthalmology
Luke Halliday, David Curragh, Dinesh Selva
Epiblepharon is a common eyelid abnormality characterised by a fold of skin overlapping the lid margin.1 It is frequently congenital, and often resolves spontaneously with growth of the facial bones during early life.1 Acquired epiblepharon is uncommon and infrequently reported. We present a case of transient bilateral epiblepharon occurring during pregnancy in an Asian woman.
April 26, 2018: Clinical & Experimental Ophthalmology
Philip J Polkinghorne, Niall Crosby, Bia Kim, Charles McGhee, Sarah Welch, Andrew Riley, Philip J Polkinghorne
IMPORTANCE: To determine if endophthamitis following cataract surgery is linked to increased mortality. BACKGROUND: Increased mortality has been linked to patients with cataract and cataract surgery. We tested the hypothesis that post-cataract endophthalitis has a greater risk of death than pseudo-phakes who don't develop this complication. DESIGN: Case control study conducted in a tertiary public hospital. PARTICIPANTS: The study group comprised of 50 consecutive patients with post-cataract endophthalmitis and these were matched selected controls...
April 24, 2018: Clinical & Experimental Ophthalmology
Ling Chen, Xiongze Zhang, Bing Liu, Lan Mi, Feng Wen
IMPORTANCE: Fundus aging and its imaging features BACKGROUND: To characterize the demographic and multimodal-imaging features of age-related scattered hypofluorescent spots on late-phase indocyanine green angiography (ASHS-LIA). DESIGN: A hospital-based retrospective study. PARTICIPANTS: 875 normal fundi fellow eyes from 875 patients underwent indocyanine green angiography (ICGA), fluorescence angiography (FA), autofluorescence (AF) and spectral-domain optical coherence tomography (OCT)...
April 19, 2018: Clinical & Experimental Ophthalmology
Abby C Dawson, Keryn A Williams, Binoy Appukuttan, Justine R Smith
Vitreoretinal lymphoma, which most commonly is diffuse large B cell non-Hodgkin in type, is a rare cancer with high morbidity and high mortality. Making a tissue diagnosis of vitreoretinal lymphoma is a major challenge for clinicians due to biological and technical factors. Yet, the delay in start of treatment may have vision- and life- threatening consequences, and there is considerable interest in the application of molecular assays to improve the accuracy of the diagnostic process: detection of a clonal immunoglobulin heavy chain rearrangements in lymphoma cells by polymerase chain reaction; measurement of vitreous or aqueous interleukin-10 protein levels in ocular fluids; and identification of mutations in the myeloid differentiation primary response gene 88 in tumour cells...
April 19, 2018: Clinical & Experimental Ophthalmology
Luke K Chehade, David Curragh, Dinesh Selva
We report a case of central retinal artery occlusion (CRAO) with cilioretinal sparing following orbital biopsy, with a review of the literature regarding post-orbital surgery CRAO. The case highlights the importance of routine post-operative observations following orbital surgery, the significance of recognizing CRAO as a potential complication, and its management.
April 17, 2018: Clinical & Experimental Ophthalmology
Xiaotong Han, Pei Ying Lee, Chi Liu, Mingguang He
IMPORTANCE: This study helps to better understand the need and trend in presbyopic add power in the aging society. BACKGROUND: Distribution and progression of presbyopic add power in East Asian population is largely unknown. DESIGN: Prospective cohort study. PARTICIPANTS: 303 participants from a population-based study of residents aged 35 years and older in Guangzhou, China. METHODS: Visual acuity (VA) test and non-cycloplegic automated refraction were performed at baseline in 2008 and the 6-year follow-up per standardized protocol...
April 16, 2018: Clinical & Experimental Ophthalmology
Alessandro Invernizzi, Vuong Nguyen, Mark Gillies
Dear Editor, we read with interest the study by Dr. Ho et al.1 about the relationship between reticular pseudodrusen (RPD) and choroidal thickness in intermediate age related macular degeneration and would like to comment on their results and conclusions.
April 16, 2018: Clinical & Experimental Ophthalmology
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