journal
MENU ▼
Read by QxMD icon Read
search

Neurosurgical Focus

journal
https://www.readbyqxmd.com/read/29385928/effects-on-cognition-and-quality-of-life-with-unilateral-magnetic-resonance-guided-focused-ultrasound-thalamotomy-for-essential-tremor
#1
Na Young Jung, Chang Kyu Park, Won Seok Chang, Hyun Ho Jung, Jin Woo Chang
OBJECTIVE Although neurosurgical procedures are effective treatments for controlling involuntary tremor in patients with essential tremor (ET), they can cause cognitive decline, which can affect quality of life (QOL). The purpose of this study is to assess the changes in the neuropsychological profile and QOL of patients following MR-guided focused ultrasound (MRgFUS) thalamotomy for ET. METHODS The authors prospectively analyzed 20 patients with ET who underwent unilateral MRgFUS thalamotomy at their institute in the period from March 2012 to September 2014...
February 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/29385927/preliminary-experience-with-a-transcranial-magnetic-resonance-guided-focused-ultrasound-surgery-system-integrated-with-a-1-5-t-mri-unit-in-a-series-of-patients-with-essential-tremor-and-parkinson-s-disease
#2
Domenico Gerardo Iacopino, Cesare Gagliardo, Antonella Giugno, Giuseppe Roberto Giammalva, Alessandro Napoli, Rosario Maugeri, Francesca Graziano, Francesca Valentino, Giuseppe Cosentino, Marco D'Amelio, Tommaso Vincenzo Bartolotta, Carlo Catalano, Brigida Fierro, Massimo Midiri, Roberto Lagalla
OBJECTIVE Transcranial magnetic resonance-guided focused ultrasound surgery (tcMRgFUS) is one of the emerging noninvasive technologies for the treatment of neurological disorders such as essential tremor (ET), idiopathic asymmetrical tremor-dominant Parkinson's disease (PD), and neuropathic pain. In this clinical series the authors present the preliminary results achieved with the world's first tcMRgFUS system integrated with a 1.5-T MRI unit. METHODS The authors describe the results of tcMRgFUS in a sample of patients with ET and with PD who underwent the procedure during the period from January 2015 to September 2017...
February 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/29385926/magnetic-resonance-guided-interstitial-high-intensity-focused-ultrasound-for-brain-tumor-ablation
#3
Jacquelyn MacDonell, Niravkumar Patel, Sebastian Rubino, Goutam Ghoshal, Gregory Fischer, E Clif Burdette, Roy Hwang, Julie G Pilitsis
Currently, treatment of brain tumors is limited to resection, chemotherapy, and radiotherapy. Thermal ablation has been recently explored. High-intensity focused ultrasound (HIFU) is being explored as an alternative. Specifically, the authors propose delivering HIFU internally to the tumor with an MRI-guided robotic assistant (MRgRA). The advantage of the authors' interstitial device over external MRI-guided HIFU (MRgHIFU) is that it allows for conformal, precise ablation and concurrent tissue sampling. The authors describe their workflow for MRgRA HIFU delivery...
February 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/29385925/predicting-lesion-size-during-focused-ultrasound-thalamotomy-a-review-of-63-lesions-over-3-clinical-trials
#4
Aaron E Bond, W Jeffrey Elias
OBJECTIVE The goal of this study was to improve the predictability of lesion size during focused ultrasound (FUS) thalamotomy procedures. METHODS Treatment profiles and T2-weighted MRI (T2 MRI) studies obtained in 63 patients who participated in 3 clinical trials of FUS thalamotomy from February 2011 to March 2015 were reviewed retrospectively. Four damage estimate models were compared with lesion sizes measured on postprocedural T2 MRI. Models were based on 54°C × 3 seconds, 240 cumulative equivalent minutes at 43°C, and simple thermal threshold analysis, which recorded the maximum diameter that reached a temperature of at least 51°C and 54°C...
February 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/29385924/neuromodulation-with-transcranial-focused-ultrasound
#5
Jan Kubanek
The understanding of brain function and the capacity to treat neurological and psychiatric disorders rest on the ability to intervene in neuronal activity in specific brain circuits. Current methods of neuromodulation incur a tradeoff between spatial focus and the level of invasiveness. Transcranial focused ultrasound (FUS) is emerging as a neuromodulation approach that combines noninvasiveness with focus that can be relatively sharp even in regions deep in the brain. This may enable studies of the causal role of specific brain regions in specific behaviors and behavioral disorders...
February 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/29385923/high-intensity-focused-ultrasound-past-present-and-future-in-neurosurgery
#6
Syed A Quadri, Muhammad Waqas, Inamullah Khan, Muhammad Adnan Khan, Sajid S Suriya, Mudassir Farooqui, Brian Fiani
Since Lynn and colleagues first described the use of focused ultrasound (FUS) waves for intracranial ablation in 1942, many strides have been made toward the treatment of several brain pathologies using this novel technology. In the modern era of minimal invasiveness, high-intensity focused ultrasound (HIFU) promises therapeutic utility for multiple neurosurgical applications, including treatment of tumors, stroke, epilepsy, and functional disorders. Although the use of HIFU as a potential therapeutic modality in the brain has been under study for several decades, relatively few neuroscientists, neurologists, or even neurosurgeons are familiar with it...
February 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/29385922/a-review-of-potential-applications-of-mr-guided-focused-ultrasound-for-targeting-brain-tumor-therapy
#7
Layton Lamsam, Eli Johnson, Ian D Connolly, Max Wintermark, Melanie Hayden Gephart
Magnetic resonance-guided focused ultrasound (MRgFUS) has been used extensively to ablate brain tissue in movement disorders, such as essential tremor. At a lower energy, MRgFUS can disrupt the blood-brain barrier (BBB) to allow passage of drugs. This focal disruption of the BBB can target systemic medications to specific portions of the brain, such as for brain tumors. Current methods to bypass the BBB are invasive, as the BBB is relatively impermeable to systemically delivered antineoplastic agents. Multiple healthy and brain tumor animal models have suggested that MRgFUS disrupts the BBB and focally increases the concentration of systemically delivered antitumor chemotherapy, immunotherapy, and gene therapy...
February 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/29385921/volumetric-analysis-of-magnetic-resonance-guided-focused-ultrasound-thalamotomy-lesions
#8
Maya Harary, Walid I Essayed, Pablo A Valdes, Nathan McDannold, G Rees Cosgrove
OBJECTIVE Magnetic resonance-guided focused ultrasound (MRgFUS) thalamotomy was recently approved for use in the treatment of medication-refractory essential tremor (ET). Previous work has described lesion appearance and volume on MRI up to 6 months after treatment. Here, the authors report on the volumetric segmentation of the thalamotomy lesion and associated edema in the immediate postoperative period and 1 year following treatment, and relate these radiographic characteristics with clinical outcome. METHODS Seven patients with medication-refractory ET underwent MRgFUS thalamotomy at Brigham and Women's Hospital and were monitored clinically for 1 year posttreatment...
February 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/29385920/a-minimally-invasive-catheter-based-ultrasound-technology-for-therapeutic-interventions-in-brain-initial-preclinical-studies
#9
Goutam Ghoshal, Lucy Gee, Tamas Heffter, Emery Williams, Corinne Bromfield, Laurie Rund, John M Ehrhardt, Chris J Diederich, Gregory S Fischer, Julie G Pilitsis, E Clif Burdette
OBJECTIVE Minimally invasive procedures may allow surgeons to avoid conventional open surgical procedures for certain neurological disorders. This paper describes the iterative process for development of a catheter-based ultrasound thermal therapy applicator. METHODS Using an ultrasound applicator with an array of longitudinally stacked and angularly sectored tubular transducers within a catheter, the authors conducted experimental studies in porcine liver, in vivo and ex vivo, in order to characterize the device performance and lesion patterns...
February 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/29385919/focused-ultrasound-in-neurosurgery-a-historical-perspective
#10
Maya Harary, David J Segar, Kevin T Huang, Ian J Tafel, Pablo A Valdes, G Rees Cosgrove
Focused ultrasound (FUS) has been under investigation for neurosurgical applications since the 1940s. Early experiments demonstrated ultrasound as an effective tool for the creation of intracranial lesions; however, they were limited by the need for craniotomy to avoid trajectory damage and wave distortion by the skull, and they also lacked effective techniques for monitoring. Since then, the development and hemispheric distribution of phased arrays has resolved the issue of the skull and allowed for a completely transcranial procedure...
February 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/29385918/magnetic-resonance-guided-high-intensity-focused-ultrasound-sonolysis-potential-applications-for-stroke
#11
Adeel Ilyas, Ching-Jen Chen, Dale Ding, Andrew Romeo, Thomas J Buell, Tony R Wang, M Yashar S Kalani, Min S Park
Stroke is one of the leading causes of death worldwide and a significant source of long-term morbidity. Unfortunately, a substantial number of stroke patients either are ineligible or do not significantly benefit from contemporary medical and interventional therapies. To address this void, investigators recently made technological advances to render transcranial MR-guided, high-intensity focused ultrasound (MRg-HIFU) sonolysis a potential therapeutic option for both acute ischemic stroke (AIS)-as an alternative for patients with emergent large-vessel occlusion (ELVO) who are ineligible for endovascular mechanical thrombectomy (EMT) or as salvage therapy for patients in whom EMT fails-and intracerebral hemorrhage (ICH)-as a neoadjuvant means of clot lysis prior to surgical evacuation...
February 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/29385917/a-meta-analysis-of-outcomes-and-complications-of-magnetic-resonance-guided-focused-ultrasound-in-the-treatment-of-essential-tremor
#12
Nasser Mohammed, Devi Patra, Anil Nanda
OBJECTIVE Magnetic resonance-guided focused ultrasound (MRgFUS) is a novel technique that uses high-intensity focused ultrasound to achieve target ablation. Like a lens focusing the sun's rays, the ultrasound waves are focused to generate heat. This therapy combines the noninvasiveness of Gamma Knife thalamotomy and the real-time ablation of deep brain stimulation with acceptable complication rates. The aim of this study was to analyze the overall outcomes and complications of MRgFUS in the treatment of essential tremor (ET)...
February 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/29385916/introduction-focused-ultrasound
#13
Nir Lipsman, W Jeffrey Elias, Ryder P Gwinn, Julie G Pilitsis
No abstract text is available yet for this article.
February 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/29385915/focused-ultrasound-mediated-noninvasive-blood-brain-barrier-modulation-preclinical-examination-of-efficacy-and-safety-in-various-sonication-parameters
#14
Jaewoo Shin, Chanho Kong, Jae Sung Cho, Jihyeon Lee, Chin Su Koh, Min-Sik Yoon, Young Cheol Na, Won Seok Chang, Jin Woo Chang
OBJECTIVE The application of pharmacological therapeutics in neurological disorders is limited by the ability of these agents to penetrate the blood-brain barrier (BBB). Focused ultrasound (FUS) has recently gained attention for its potential application as a method for locally opening the BBB and thereby facilitating drug delivery into the brain parenchyma. However, this method still requires optimization to maximize its safety and efficacy for clinical use. In the present study, the authors examined several sonication parameters of FUS influencing BBB opening in small animals...
February 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/29385914/transcranial-magnetic-resonance-imaging-guided-focused-ultrasound-thalamotomy-for-tremor-technical-note
#15
Tony R Wang, Aaron E Bond, Robert F Dallapiazza, Aaron Blanke, David Tilden, Thomas E Huerta, Shayan Moosa, Francesco U Prada, W Jeffrey Elias
Although the use of focused ultrasound (FUS) in neurosurgery dates to the 1950s, its clinical utility was limited by the need for a craniotomy to create an acoustic window. Recent technological advances have enabled efficient transcranial delivery of US. Moreover, US is now coupled with MRI to ensure precise energy delivery and monitoring. Thus, MRI-guided transcranial FUS lesioning is now being investigated for myriad neurological and psychiatric disorders. Among the first transcranial FUS treatments is thalamotomy for the treatment of various tremors...
February 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/29385913/erratum-initial-experience-with-a-robotically-operated-video-optical-telescopic-microscope-in-cranial-neurosurgery-feasibility-safety-and-clinical-applications
#16
https://www.readbyqxmd.com/read/29385912/editorial-tremor-thalamotomy-and-cognition
#17
Ying Meng, Nir Lipsman
No abstract text is available yet for this article.
February 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/29291298/neurofibroma-of-the-peroneal-nerve
#18
Clayton Haldeman, Amgad Hanna
Neurofibromas are benign tumors composed of different cell types from the peripheral nervous system. Neurofibromas infiltrate between nerve fascicles and do not have a discrete capsule. On MRI, they are T1 hypointense or isointense, T2 hyperintense, often with a "target sign," and contrast enhancing. The video shows gross-total resection of a peroneal nerve neurofibroma presenting as a painful mass in the popliteal fossa. Incisions across a skin crease can be either oblique or zigzag, but never perpendicular to it...
January 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/29291297/surgical-repair-of-sciatic-nerve-traumatic-rupture-technical-considerations-and-approaches
#19
Hussam Abou-Al-Shaar, Nam Yoon, Mark A Mahan
Traumatic proximal sciatic nerve rupture poses surgical repair dilemmas. Disruption often causes a large nerve gap after proximal neuroma and distal scar removal. Also, autologous graft material to bridge the segmental defect may be insufficient, given the sciatic nerve diameter. The authors utilized knee flexion to allow single neurorrhaphy repair of a large sciatic nerve defect, bringing healthy proximal stump to healthy distal segment. To avoid aberrant regeneration, the authors split the sciatic nerve into common peroneal and tibial divisions...
January 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/29291296/acute-repair-of-traumatic-pan-brachial-plexus-injury-technical-considerations-and-approaches
#20
Hussam Abou-Al-Shaar, Michael Karsy, Vijay Ravindra, Evan Joyce, Mark A Mahan
Particularly challenging after complete brachial plexus avulsion is reestablishing effective hand function, due to limited neurological donors to reanimate the arm. Acute repair of avulsion injuries may enable reinnervation strategies for achieving hand function. This patient presented with pan-brachial plexus injury. Given its irreparable nature, the authors recommended multistage reconstruction, including contralateral C-7 transfer for hand function, multiple intercostal nerves for shoulder/triceps function, shoulder fusion, and spinal accessory nerve-to-musculocutaneous nerve transfer for elbow flexion...
January 2018: Neurosurgical Focus
journal
journal
34803
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"