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Revista Brasileira de Psiquiatria

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https://www.readbyqxmd.com/read/28177063/prevalence-of-and-factors-associated-with-antipsychotic-polypharmacy-in-patients-with-serious-mental-illness-findings-from-a-cross-sectional-study-in-an-upper-middle-income-country
#1
Kerryn S Armstrong, Henk Temmingh
Objective: The aim of our study was to examine the prevalence of and factors associated with antipsychotic polypharmacy (APP) among patients with serious mental illness in the current South African health care context. Methods: We collected data on patient, illness, and treatment characteristics of patients discharged on one or more antipsychotic agents from January to June 2014. We analyzed the associations of APP with demographic and clinical variables using hierarchical multivariable logistic regression, and examined prescription patterns...
February 6, 2017: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/28177062/critical-neuropsychobiological-analysis-of-panic-attack-and-anticipatory-anxiety-like-behaviors-in-rodents-confronted-with-snakes-in-polygonal-arenas-and-complex-labyrinths-a-comparison-to-the-elevated-plus-and-t-maze-behavioral-tests
#2
Norberto C Coimbra, Tatiana Paschoalin-Maurin, Gabriel S Bassi, Alexandre Kanashiro, Audrey F Biagioni, Tatiana T Felippotti, Daoud H Elias-Filho, Joyce Mendes-Gomes, Jade P Cysne-Coimbra, Rafael C Almada, Bruno Lobão-Soares
Objective: To compare prey and snake paradigms performed in complex environments to the elevated plus-maze (EPM) and T-maze (ETM) tests for the study of panic attack- and anticipatory anxiety-like behaviors in rodents. Methods: PubMed was reviewed in search of articles focusing on the plus maze test, EPM, and ETM, as well as on defensive behaviors displayed by threatened rodents. In addition, the authors' research with polygonal arenas and complex labyrinth (designed by the first author for confrontation between snakes and small rodents) was examined...
February 6, 2017: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/28099631/associations-of-cerebrovascular-metabolism-genotypes-with-neuropsychiatric-symptoms-and-age-at-onset-of-alzheimer-s-disease-dementia
#3
Fabricio F de Oliveira, Elizabeth S Chen, Marilia C Smith, Paulo H Bertolucci
Objective: To study associations of cerebrovascular metabolism genotypes and haplotypes with age at Alzheimer's disease dementia (AD) onset and with neuropsychiatric symptoms according to each dementia stage. Methods: Consecutive outpatients with late-onset AD were assessed for age at dementia onset and Neuropsychiatric Inventory scores according to Clinical Dementia Rating scores, apolipoprotein E gene (APOE) haplotypes, angiotensin-converting enzyme gene (ACE) variants rs1800764 and rs4291, low-density lipoprotein cholesterol receptor gene (LDLR) variants rs11669576 and rs5930, cholesteryl ester transfer protein gene (CETP) variants I422V and TaqIB, and liver X receptor beta gene (NR1H2) polymorphism rs2695121...
January 12, 2017: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/28099630/the-brain-derived-neurotrophic-factor-bdnf-gene-val66met-polymorphism-affects-memory-performance-in-older-adults
#4
Lucas A de Azeredo, Tatiana De Nardi, Mateus L Levandowski, Saulo G Tractenberg, Julia Kommers-Molina, Andrea Wieck, Tatiana Q Irigaray, Irênio G da Silva, Rodrigo Grassi-Oliveira
Objective: Memory impairment is an important contributor to the reduction in quality of life experienced by older adults, and genetic risk factors seem to contribute to variance in age-related cognitive decline. Brain-derived neurotrophic factor (BDNF) is an important nerve growth factor linked with development and neural plasticity. The Val66Met polymorphism in the BDNF gene has been associated with impaired episodic memory in adults, but whether this functional variant plays a role in cognitive aging remains unclear...
January 12, 2017: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/28099629/the-role-of-the-cnr1-gene-in-schizophrenia-a-systematic-review-including-unpublished-data
#5
Eduardo S Gouvêa, Airton F Santos, Vanessa K Ota, Vinicius Mrad, Ary Gadelha, Rodrigo A Bressan, Quirino Cordeiro, Sintia I Belangero
Objective: Schizophrenia is a multifactorial disorder. It is known that a combination of extensive multiple common alleles may be involved in its etiology, each contributing with a small to moderate effect, and, possibly, some rare alleles with a much larger effect size. We aimed to perform a systematic review of association studies between schizophrenia (and its subphenotypes) and polymorphisms in the CNR1 gene, which encodes cannabinoid receptors classically implicated in schizophrenia pathophysiology, as well as to present unpublished results of an association study in a Brazilian population...
January 12, 2017: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/28099628/elevated-plasma-concentrations-of-s100-calcium-binding-protein-b-and-tumor-necrosis-factor-alpha-in-children-with-autism-spectrum-disorders
#6
Selin Aktan Guloksuz, Osman Abali, Esin Aktas Cetin, Sema Bilgic Gazioglu, Gunnur Deniz, Abdurrahman Yildirim, Ivana Kawikova, Sinan Guloksuz, James F Leckman
Objective: To investigate plasma concentrations of S100B (a calcium-binding protein derived primarily from the glia) and inflammatory cytokines in children with autism and the relationship between S100B and cytokine concentrations. Methods: Plasma levels of S100B, tumor necrosis factor alpha (TNF-α), interferon gamma, interleukin (IL)-1β, IL-4, IL-6, IL-10, and IL-17A were measured in 40 unmedicated children with autism and 35 normally developing healthy children...
January 12, 2017: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/28076650/chronotype-and-anxiety-are-associated-in-patients-with-chronic-primary-insomnia
#7
Giselle S Passos, Marcos G Santana, Dalva Poyares, Carolina V D'Aurea, Alexandre A Teixeira, Sergio Tufik, Marco T de Mello
Objective: To assess the interaction of chronotype with anxiety in patients with chronic primary insomnia. Methods: Sixty-four patients (50 women) with mean age 43.9±8.1 years were investigated with the Horne and Östberg Morningness-Eveningness Questionnaire (MEQ) and State-Trait Anxiety Inventory (STAI). Results: Significant negative correlations of chronotype-MEQ score with STAI state-anxiety (r = -0.40, p < 0.05), STAI trait-anxiety (r = -0...
January 9, 2017: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/28076649/suicide-attempts-in-bipolar-i-patients-impact-of-comorbid-personality-disorders
#8
Severino Bezerra, Amanda Galvão-de-Almeida, Paula Studart, Davi F Martins, André C Caribé, Paulo A Schwingel, Ângela Miranda-Scippa
Objective: To evaluate the association between personality disorders (PDs) and suicide attempts (SAs) in euthymic patients with type I bipolar disorder (BD). Methods: One-hundred twenty patients with type I BD, with and without history of SA, were evaluated during euthymia. The assessment included a clinical and sociodemographic questionnaire, the Hamilton Depression Rating Scale, the Young Mania Rating Scale, the Barratt Impulsiveness Scale, and Structured Clinical Interviews for DSM-IV Axis I and II Disorders...
January 9, 2017: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/28076648/latent-class-profile-of-psychiatric-symptoms-and-treatment-utilization-in-a-sample-of-patients-with-co-occurring-disorders
#9
Luis Villalobos-Gallegos, Rodrigo Marín-Navarrete, Calos Roncero, Hugo González-Cantú
Objective: To identify symptom-based subgroups within a sample of patients with co-occurring disorders (CODs) and to analyze intersubgroup differences in mental health services utilization. Methods: Two hundred and fifteen patients with COD from an addiction clinic completed the Symptom Checklist 90-Revised. Subgroups were determined using latent class profile analysis. Services utilization data were collected from electronic records during a 3-year span. Results: The five-class model obtained the best fit (Bayesian information criteria [BIC] = 3,546...
January 9, 2017: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/28076647/sex-specific-cognitive-abnormalities-in-early-onset-psychosis
#10
Miguel Ruiz-Veguilla, Josefa Moreno-Granados, Maria D Salcedo-Marin, Maria L Barrigon, Maria J Blanco-Morales, Evelio Igunza, Anselmo Cañabate, Maria D Garcia, Teresa Guijarro, Francisco Diaz-Atienza, Maite Ferrin
Objectives: Brain maturation differs depending on the area of the brain and sex. Girls show an earlier peak in maturation of the prefrontal cortex. Although differences between adult females and males with schizophrenia have been widely studied, there has been less research in girls and boys with psychosis. The purpose of this study was to examine differences in verbal and visual memory, verbal working memory, auditory attention, processing speed, and cognitive flexibility between boys and girls...
January 9, 2017: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/27982293/postpartum-depression-bipolar-or-unipolar-analysis-of-434-polish-postpartum-women
#11
Rafał R Jaeschke, Dominika Dudek, Roman Topór-Mądry, Katarzyna Drozdowicz, Wojciech Datka, Marcin Siwek, Janusz Rybakowski
Objective: To assess the prevalence of soft bipolar features in a sample of women with postpartum depressive symptoms, as well as to compare the sociodemographic and obstetric characteristics of subjects with bipolar or unipolar postpartum depressive symptomatology. Methods: Four hundred and thirty-four participants were enrolled in this cross-sectional study. Postpartum depression (PPD) symptoms were assessed using the Edinburgh Postnatal Depression Scale (EPDS), while the Mood Disorder Questionnaire (MDQ) was used to screen for bipolarity features...
December 8, 2016: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/27901215/a-systematic-review-of-the-neural-correlates-of-positive-emotions
#12
Leonardo Machado, Amaury Cantilino
Objective: To conduct a systematic literature review of human studies reporting neural correlates of positive emotions. Methods: The PubMed and Web of Science databases were searched in January 2016 for scientific papers written in English. No restrictions were placed on year of publication. Results: Twenty-two articles were identified and 12 met the established criteria. Five had been published during the last 4 years. Formation and regulation of positive emotions, including happiness, are associated with significant reductions in activity in the right prefrontal cortex and bilaterally in the temporoparietal cortex, as well as with increased activity in the left prefrontal regions...
November 24, 2016: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/27901214/predictors-of-response-in-the-treatment-of-moderate-depression
#13
Andre G Bastos, Luciano S Guimarães, Clarissa M Trentini
Objective: To identify neurocognitive and sociodemographic variables that could be associated with clinical response to three modalities of treatment for depression, as well as variables that predicted superior response to one treatment over the others. Method: The present study derives from a research project in which depressed patients (n=272) received one of three treatments - long-term psychodynamic psychotherapy (n=90), fluoxetine therapy (n=91), or a combination thereof (n=91) - over a 24-month period...
November 24, 2016: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/27901213/the-rs11191580-variant-of-the-nt5c2-gene-is-associated-with-schizophrenia-and-symptom-severity-in-a-south-chinese-han-population-evidence-from-gwas
#14
Zhen Li, Juan Jiang, Jianxiong Long, Weijun Ling, Guifeng Huang, Xiaojing Guo, Li Su
Objective: Recent genome-wide association studies have identified a significant relationship between the NT5C2 variant rs11191580 and schizophrenia (SCZ) in European populations. This study aimed to validate the association of rs11191580 polymorphism with SCZ risk in a South Chinese Han population. The relationship of this polymorphism with the severity of SCZ clinical symptoms was also explored. Methods: A case-control study was performed in 462 patients with SCZ and 598 healthy controls...
November 24, 2016: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/27901212/validation-of-the-brazilian-portuguese-version-of-the-premenstrual-symptoms-screening-tool-psst-and-association-of-psst-scores-with-health-related-quality-of-life
#15
Rachel de A Câmara, Cristiano A Köhler, Benicio N Frey, Thomas N Hyphantis, André F Carvalho
Objective: To develop and validate a Brazilian Portuguese version of the Premenstrual Symptoms Screening Tool (PSST), a questionnaire used for the screening of premenstrual syndrome (PMS) and of the most severe form of PMS, premenstrual dysphoric disorder (PMDD). The PSST also rates the impact of premenstrual symptoms on daily activities. Methods: A consecutive sample of 801 women aged ≥ 18 years completed the study protocol. The internal consistency, test-retest reliability, and content validity of the Brazilian PSST were determined...
November 24, 2016: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/27901211/how-to-tell-a-happy-from-an-unhappy-schizotype-personality-factors-and-mental-health-outcomes-in-individuals-with-psychotic-experiences
#16
Letícia O Alminhana, Miguel Farias, Gordon Claridge, Claude R Cloninger, Alexander Moreira-Almeida
Objective: It is unclear why some individuals reporting psychotic experiences have balanced lives while others go on to develop mental health problems. The objective of this study was to test if the personality traits of harm avoidance, self-directedness, and self-transcendence can be used as criteria to differentiate healthy from unhealthy schizotypal individuals. Methods: We interviewed 115 participants who reported a high frequency of psychotic experiences. The instruments used were the Temperament and Character Inventory (140), Structured Clinical Interview for DSM-IV, and the Oxford-Liverpool Inventory of Feelings and Experiences...
November 24, 2016: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/27828668/symptoms-of-anxiety-and-depression-are-related-to-cardiovascular-responses-to-active-but-not-passive-coping-tasks
#17
Kornanong Yuenyongchaiwat, Ian S Baker, David Sheffield
Objective: Anxiety and depression have been linked to blunted blood pressure (BP) and heart rate (HR) reactions to mental stress tests; however, most studies have not included indices of underlying hemodynamics nor multiple stress tasks. This study sought to examine the relationships of anxiety and depression with hemodynamic responses to acute active and passive coping tasks. Methods: A total of 104 participants completed the Hospital Anxiety and Depression Scales and mental arithmetic, speech, and cold pressor tasks while BP, HR, total peripheral resistance, and cardiac output (CO) were assessed...
November 7, 2016: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/27828667/development-and-validation-of-the-gambling-follow-up-scale-self-report-version-an-outcome-measure-in-the-treatment-of-pathological-gambling
#18
Ana M Galetti, Hermano Tavares
Objective: To validate the Gambling Follow-up Scale, Self-Report version (GFS-SR), a 10-item scale designed to assess gambling frequency, time and money spent on gambling, gambling craving, debts, emotional distress, family relationships, autonomy, and frequency of and satisfaction with leisure activities in individuals diagnosed with gambling disorder according to the DSM-5 criteria. Methods: One hundred and twenty treatment-seeking gamblers were evaluated, 84 of whom proceeded to treatment...
November 7, 2016: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/27783716/the-biological-rhythms-interview-of-assessment-in-neuropsychiatry-in-patients-with-bipolar-disorder-correlation-with-affective-temperaments-and-schizotypy
#19
Ewa Dopierala, Adrian A Chrobak, Flavio Kapczinski, Michal Michalak, Anna Tereszko, Ewa Ferensztajn-Rochowiak, Dominika Dudek, Daria Dembinska-Krajewska, Marcin Siwek, Jan Jaracz, Janusz K Rybakowski
Objective: To assess the relationship of biological rhythms, evaluated by the Biological Rhythms Interview of Assessment in Neuropsychiatry (BRIAN), with affective temperaments and schizotypy. Methods: The BRIAN assessment, along with the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego-Autoquestionnaire (TEMPS-A) and the Oxford-Liverpool Inventory for Feelings and Experiences (O-LIFE), was administered to 54 patients with remitted bipolar disorder (BD) and 54 healthy control (HC) subjects...
October 20, 2016: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/27783715/suicide-detection-in-chile-proposing-a-predictive-model-for-suicide-risk-in-a-clinical-sample-of-patients-with-mood-disorders
#20
Jorge Barros, Susana Morales, Orietta Echávarri, Arnol García, Jaime Ortega, Takeshi Asahi, Claudia Moya, Ronit Fischman, María P Maino, Catalina Núñez
Objective: To analyze suicidal behavior and build a predictive model for suicide risk using data mining (DM) analysis. Methods: A study of 707 Chilean mental health patients (with and without suicide risk) was carried out across three healthcare centers in the Metropolitan Region of Santiago, Chile. Three hundred forty-three variables were studied using five questionnaires. DM and machine-learning tools were used via the support vector machine technique. Results: The model selected 22 variables that, depending on the circumstances in which they all occur, define whether a person belongs in a suicide risk zone (accuracy = 0...
October 20, 2016: Revista Brasileira de Psiquiatria
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