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American Journal of Clinical Dermatology

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https://www.readbyqxmd.com/read/28074446/efficacy-and-safety-of-switching-to-ixekizumab-in-etanercept-non-responders-a-subanalysis-from-two-phase-iii-randomized-clinical-trials-in-moderate-to-severe-plaque-psoriasis-uncover-2-and-3
#1
Andrew Blauvelt, Kim A Papp, Christopher E M Griffiths, Luis Puig, Jamie Weisman, Yves Dutronc, Lisa Farmer Kerr, Dapo Ilo, Lotus Mallbris, Matthias Augustin
BACKGROUND: Patients with psoriasis who have an inadequate response to one biologic may benefit from switching to a new biologic, such as ixekizumab, a high affinity monoclonal antibody that selectively targets interleukin (IL)-17A. OBJECTIVE: Our aim was to assess the response to ixekizumab in patients with moderate-to-severe plaque psoriasis who did not respond adequately to etanercept using a post-hoc analysis in two phase III studies. METHODS: For the subanalyses in two phase III trials (UNCOVER-2 and -3), non-response was defined by either failure to have a static physician global assessment (sPGA) of 0/1 in UNCOVER-2 or failure to have at least 75% improvement in psoriasis area and severity index (PASI 75) in UNCOVER-3 at Week 12 of each study...
January 10, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28063095/the-use-of-cosmeceuticals-in-acne-help-or-hoax
#2
Brittany S Barros, Andrea L Zaenglein
The use of cosmeceuticals by patients with acne is common; however, their role is unclear and confusing, with many asking, "Do they really help acne?" Cosmeceuticals are intermediate products between prescription medications and cosmetics, available to consumers over the counter. These products are popular and may be used without the direct supervision of a dermatologist, creating a practice gap in educating patients. Herein, a variety of cosmeceuticals are discussed, including retinoids, niacinamide, and glycolic acid...
January 6, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28063094/stasis-dermatitis-pathophysiology-evaluation-and-management
#3
REVIEW
Swaminathan Sundaresan, Michael R Migden, Sirunya Silapunt
Stasis dermatitis commonly occurs in older age. It is caused by venous hypertension resulting from retrograde flow due to incompetent venous valves, valve destruction, or obstruction of the venous system. Further tissue changes arise from an inflammatory process mediated by metalloproteinases, which are up-regulated by ferric ion from extravasated red blood cells. Stasis dermatitis presents initially as poorly demarcated erythematous plaques of the lower legs bilaterally, classically involving the medial malleolus...
January 6, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28063093/honey-and-wound-healing-an-update
#4
REVIEW
Sami K Saikaly, Amor Khachemoune
For centuries, honey has been utilized for wound healing purposes. In recent times, this specific topic has become a field of interest, possibly due to the advent of antibiotic resistance in microbial pathogens. With constant technological advancement, the information regarding honey's mechanisms of action on wound healing has accumulated at a rapid pace. Similarly, clinical studies comparing honey with traditional wound care therapies are steadily emerging. As a follow-up to a previous review published in the journal in 2011, the current review article outlines publications regarding honey and wound healing that have been published between June 2010 and August 2016...
January 6, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28035650/the-emerging-zika-virus-threat-a-guide-for-dermatologists
#5
REVIEW
Alice He, Patrícia Brasil, Andre M Siqueira, Guilherme A Calvet, Shawn G Kwatra
We provide a guide for dermatologists to follow if they encounter patients with a rash and clinical history suspicious of Zika virus infection, including diagnostic testing and management options. We also provide an illustrative case report of a patient from Brazil who was diagnosed with Zika virus infection after presenting with a generalized pruritic rash. One of the most prominent symptoms of Zika virus infection is a cutaneous eruption. As such, it is especially necessary for dermatologists to understand this virus so that they may appropriately recognize this entity as a diagnostic consideration in the clinic...
December 29, 2016: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28035649/melanoma-perception-in-people-of-color-a-targeted-educational-intervention
#6
Lucy X Chao, Stavonnie S L Patterson, Alfred W Rademaker, Dachao Liu, Roopal V Kundu
BACKGROUND: Although melanoma is more common in non-Hispanic Whites, ethnic minorities face a greater risk of melanoma-related mortality, which may be partially attributed to presentation at atypical sites and a lack of awareness. OBJECTIVE: Our objective was to assess the effectiveness of a melanoma educational intervention targeted towards people of color. DESIGN: Participants received one of two scripted melanoma educational interventions in the summer of 2015...
December 29, 2016: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28005194/dapsone-7-5-gel-a-review-in-acne-vulgaris
#7
Zaina T Al-Salama, Emma D Deeks
Dapsone 7.5% gel (Aczone(®)) is indicated for the once-daily topical treatment of acne vulgaris in patients aged ≥12 years. Dapsone is a sulfone antibacterial with anti-inflammatory actions, which are thought to be largely responsible for its efficacy in treating acne vulgaris. In two phase III trials of 12 weeks' duration in patients aged ≥12 years with moderate acne vulgaris, once-daily dapsone 7.5% gel reduced acne severity (as per the Global Acne Assessment Score) and lesion counts versus vehicle...
December 22, 2016: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28004257/literature-review-of-cosmetic-procedures-in-men-approaches-and-techniques-are-gender-specific
#8
REVIEW
Brandon E Cohen, Sameer Bashey, Ashley Wysong
The proportion of men receiving non-surgical cosmetic procedures has risen substantially in recent years. Various physiologic, anatomic, and motivational considerations differentiate the treatments for male and female patients. Nevertheless, research regarding approaches to the male cosmetic patient is scarce. We sought to provide an overview and sex-specific discussion of the most popular cosmetic dermatologic procedures pursued by men by conducting a comprehensive literature review pertaining to non-surgical cosmetic procedures in male patients...
December 21, 2016: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/27988837/talimogene-laherparepvec-t-vec-and-other-oncolytic-viruses-for-the-treatment-of-melanoma
#9
Praveen K Bommareddy, Anand Patel, Saamia Hossain, Howard L Kaufman
Many mammalian viruses have properties that can be commandeered for the treatment of cancer. These characteristics include preferential infection and replication in tumor cells, the initiation of tumor cell lysis, and the induction of innate and adaptive anti-tumor immunity. Furthermore, viruses can be genetically engineered to reduce pathogenicity and increase immunogenicity resulting in minimally toxic therapeutic agents. Talimogene laherparepvec (T-VEC; Imlygic™), is a genetically modified herpes simplex virus, type 1, and is the first oncolytic virus therapy to be approved for the treatment of advanced melanoma by the US FDA...
December 17, 2016: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/27943085/facial-hyperpigmentation-in-skin-of-color-special-considerations-and-treatment
#10
Neelam A Vashi, Stephen A Wirya, Meyene Inyang, Roopal V Kundu
Differences in cutaneous diseases in people of color call for nuanced evaluation and management. One of the most common dermatological complaints from patients with skin of color is dyspigmentation, particularly hyperpigmentation. The challenge for clinicians is to establish correct diagnoses along with consistently successful treatments to meet the needs of the increasingly diverse population served. This review focuses on facial hyperpigmentation and outlines the most common skin disorders and treatment options...
December 9, 2016: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/27943084/need-for-improved-skin-cancer-surveillance-in-pediatric-cancer-survivors
#11
Divya Sharma, Thomas Lee, Adam J Friedman, Kelley Pagliai Redbord
Survivors of pediatric cancer are at increased risk of developing secondary malignancies, with non-melanoma skin cancer being the most common. These patients are also at increased risk of melanoma. Currently, guidelines provided by the National Cancer Institute and Children's Oncology Group emphasize the importance of annual clinical examination for skin cancer screening; however, the literature reports that less than one-third of survivors of pediatric cancer have ever had a clinical skin exam by a physician...
December 9, 2016: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/27913962/bathing-and-associated-treatments-in-atopic-dermatitis
#12
REVIEW
Julia K Gittler, Jason F Wang, Seth J Orlow
Atopic dermatitis is one of the most common complaints presenting to dermatologists, and patients typically inquire as to appropriate bathing recommendations. Although many dermatologists, allergists, and primary-care practitioners provide explicit bathing instructions, recommendations regarding frequency of bathing, duration of bathing, and timing related to emollient and medication application relative to bathing vary widely. Conflicting and vague guidelines stem from knowledge related to the disparate effects of water on skin, as well as a dearth of studies, especially randomized controlled trials, evaluating the effects of water and bathing on the skin of patients with atopic dermatitis...
December 3, 2016: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/27878477/paraneoplastic-pemphigus-and-autoimmune-blistering-diseases-associated-with-neoplasm-characteristics-diagnosis-associated-neoplasms-proposed-pathogenesis-treatment
#13
REVIEW
Saritha Kartan, Vivian Y Shi, Ashley K Clark, Lawrence S Chan
Autoimmune paraneoplastic and neoplasm-associated skin syndromes are characterized by autoimmune-mediated cutaneous lesions in the presence of a neoplasm. The identification of these syndromes provides information about the underlying tumor, systemic symptoms, and debilitating complications. The recognition of these syndromes is particularly helpful in cases of skin lesions presenting as the first sign of the malignancy, and the underlying malignancy can be treated in a timely manner. Autoimmune paraneoplastic and neoplasm-associated bullous skin syndromes are characterized by blister formation due to an autoimmune response to components of the epidermis or basement membrane in the context of a neoplasm...
November 22, 2016: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/27854065/the-utility-of-text-message-reminders-for-acne-patients-a-pilot-study
#14
Jean-Phillip Okhovat, Francesca Tenconi, Jenny Kim, Christina N Kim
BACKGROUND: Acne vulgaris is one of the three most common cutaneous disorders, affecting approximately 50 million people in the US and many more throughout the world. OBJECTIVE: We designed a pilot program to explore how patients may interact with cell phone technology to supplement medical care beyond patient reminders that would encompass education, interaction, and data capturing. METHODS: Twenty-four patients completed a 3-month study in which participants received daily text message reminders for the first 2 weeks of the study, then once weekly thereafter, to take their oral medication or apply topical therapy either once or twice daily...
November 16, 2016: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/27826815/is-there-a-role-for-opportunistic-infection-prophylaxis-in-pemphigus-an-expert-survey
#15
Yael A Leshem, Igor Snast, Rivka Friedland, Lihi Atzmony, Assi Levi, Emmilia Hodak, Daniel Mimouni
BACKGROUND: Opportunistic infections (OIs) are a dreaded adverse effect of immunosuppressive therapy, leading to the use of opportunistic infection prophylaxis (OIP) in many immunosuppressed conditions. However, guidelines for OIP in pemphigus are lacking. OBJECTIVE: Our objective was to evaluate the approach of leading pemphigus experts towards OIP. METHODS: We conducted an online survey of OIP trends. RESULTS: The survey was completed by 33 experts...
November 8, 2016: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/27804089/topical-treatment-of-facial-seborrheic-dermatitis-a-systematic-review
#16
REVIEW
Aditya K Gupta, Sarah G Versteeg
BACKGROUND: Facial seborrheic dermatitis (SD), a chronic inflammatory skin condition, can impact quality of life, and relapses can be frequent. Three broad categories of agents are used to treat SD: antifungal agents, keratolytics, and corticosteroids. Topical therapies are the first line of defense in treating this condition. OBJECTIVE: Our objective was to critically review the published literature on topical treatments for facial SD. METHODS: We searched PubMed, Scopus, Clinicaltrials...
November 2, 2016: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/27770310/treating-alopecia-areata-current-practices-versus-new-directions
#17
Aditya K Gupta, Jessie Carviel, William Abramovits
Alopecia areata (AA) is non-scarring hair loss resulting from an autoimmune disorder. Severity varies from patchy hair loss that often spontaneously resolves to severe and chronic cases that can progress to total loss of scalp and body hair. Many treatments are available; however, the efficacy of these treatments has not been confirmed, especially in severe cases, and relapse rates are high. First-line treatment often includes corticosteroids such as intralesional or topical steroids for mild cases and systemic steroids or topical immunotherapy with diphenylcyclopropenone or squaric acid dibutylester in severe cases...
October 22, 2016: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/27826816/acknowledgement-to-referees
#18
(no author information available yet)
No abstract text is available yet for this article.
December 2016: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/27815915/body-region-involvement-and-quality-of-life-in-psoriasis-analysis-of-a-randomized-controlled-trial-of-adalimumab
#19
April W Armstrong, Delfina Guadalupe Villanueva Quintero, Cristina M Echeverría, Yihua Gu, Mahinda Karunaratne, Ofelia Reyes Servín
BACKGROUND: Psoriasis severity and treatment responsiveness vary by body region, which differentially impacts quality of life (QoL). OBJECTIVE: The objective of the study was to examine adalimumab efficacy by body region and regional response and QoL relationship. METHODS: Patients (n = 1212) with moderate-to-severe psoriasis were randomized 2:1 to 80 mg at week 0, followed by adalimumab 40 mg or placebo every other week for 16 weeks in the double-blind REVEAL study...
December 2016: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/27785707/medical-malpractice-in-dermatology-part-ii-%C3%A2-what-to-do-once-you-have-been-served-with-a-lawsuit
#20
Vidhi V Shah, Marshall B Kapp, Stephen E Wolverton
Facing a malpractice lawsuit can be a daunting and traumatic experience for healthcare practitioners, with most clinicians naïve to the legal landscape. It is crucial for physicians to know and understand the malpractice system and his or her role once challenged with litigation. We present part II of a two-part series addressing the most common medicolegal questions that cause a great deal of anxiety. Part I focused upon risk-management strategies and prevention of malpractice lawsuits, whereas part II provides helpful suggestions and guidance for the physician who has been served with a lawsuit complaint...
December 2016: American Journal of Clinical Dermatology
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