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American Journal of Clinical Dermatology

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https://www.readbyqxmd.com/read/28624960/drug-induced-pyoderma-gangrenosum-a-review
#1
REVIEW
Jane Y Wang, Lars E French, Neil H Shear, Afkham Amiri, Afsaneh Alavi
Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis that may be caused by an adverse drug reaction. We discuss the clinical presentation and outcomes of 52 cases of drug-induced PG reported to date in the literature. We conducted our literature search for case reports of drug-induced PG using keywords on PubMed and Medical Subject Heading (MeSH) terms on MEDLINE and EMBASE. To assess the probability that each case of PG was related to drug therapy, we used the Naranjo criteria. We identified 44 studies in the literature, with a total of 52 cases of drug-induced PG...
June 17, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28624959/systematic-review-of-diagnostic-criteria-used-in-atopic-dermatitis-randomized-controlled-trials
#2
REVIEW
Paras P Vakharia, Rishi Chopra, Jonathan I Silverberg
BACKGROUND: Numerous diagnostic criteria for atopic dermatitis are used in clinical trials, which may limit comparison of results. OBJECTIVE: We sought to determine the most commonly used atopic dermatitis diagnostic criteria in randomized controlled trials internationally. METHODS: We performed a systematic review of randomized controlled trials with a pharmacological intervention from 2007 to 2016. Cochrane Library, EMBASE, GREAT, LILACS, MEDLINE, and Scopus were searched...
June 17, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28597182/apremilast-a-novel-oral-treatment-for-psoriasis-and-psoriatic-arthritis
#3
REVIEW
Tiago Torres, Luis Puig
Psoriasis is a chronic immune-mediated disease associated with several co-morbidities and negative impacts on a patient's quality of life. Despite the advances in biologic therapy, there are still unmet needs in the treatment of psoriasis, as current treatments are limited in terms of long-term efficacy, tolerability, safety, route of administration, and cost. Apremilast is an oral, small-molecule phosphodiesterase 4 inhibitor that works intracellularly by blocking the degradation of cyclic adenosine 3',5'-monophosphate, resulting in increased intracellular cyclic adenosine 3',5'-monophosphate levels in phosphodiesterase 4-expressing cells...
June 8, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28597181/clinical-signs-pathophysiology-and-management-of-cutaneous-side-effects-of-anti-tumor-necrosis-factor-agents
#4
REVIEW
Siegfried Segaert, Caroline Hermans
Approximately one in four patients treated with anti-TNF agents (infliximab, etanercept, adalimumab, certolizumab, and golimumab) develops cutaneous adverse events, typically months to years after the initiation of treatment, with xerosis cutis, eczema (often psoriasiform), psoriasis, palmoplantar pustulosis, cutaneous infections, alopecia, and skin cancer being the most frequently encountered. The typical skin lesion of anti-tumor necrosis factor (TNF)-treated patients is orange-red psoriasiform eczema affecting the flexures, genitalia, scalp, or face, with high susceptibility to bacterial superinfection with Staphylococcus aureus...
June 8, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28597180/author-s-reply-to-cohen-facial-hyperpigmentation-in-skin-of-color-special-considerations-and-treatment
#5
LETTER
Neelam A Vashi, Mayra B C Maymone, Roopal V Kundu
No abstract text is available yet for this article.
June 8, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28597179/comment-on-facial-hyperpigmentation-in-skin-of-color-special-considerations-and-treatment
#6
LETTER
Philip R Cohen
No abstract text is available yet for this article.
June 8, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28597178/comment-on-assessing-pruritus-in-hidradenitis-suppurativa-a-cross-sectional-study
#7
LETTER
José C Pascual, Pedro Alvarez, Belén Encabo, Iris González, Patricia Hispán, Inés Poveda, David Romero
No abstract text is available yet for this article.
June 8, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28577207/vitiligo-an-update-on-pathophysiology-and-treatment-options
#8
REVIEW
Reinhart Speeckaert, Nanja van Geel
The pathophysiology of vitiligo is becoming increasingly clarified. In non-segmental vitiligo, early factors include activation of innate immunity, inflammasome activation, oxidative stress, and loss of melanocyte adhesion. Nonetheless, the main mechanism leading to non-segmental vitiligo involves an immune-mediated destruction of melanocytes. Anti-melanocyte-specific cytotoxic T cells exert a central role in the final effector stage. Genetic research revealed a multi-genetic inheritance displaying an overlap with other autoimmune disorders...
June 2, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28555441/alopecia-areata-of-the-beard-a-review-of-the-literature
#9
REVIEW
Jessica Cervantes, Raymond M Fertig, Austin Maddy, Antonella Tosti
Alopecia areata (AA) is a T-cell mediated autoimmune disorder in which inflammatory cells attack the hair follicle, resulting in round, well-circumscribed patches of noncicatricial hair loss in normal appearing skin. AA affecting the beard area is well known and is referred to as AA of the beard (BAA) or AA barbae when involvement is limited exclusively to the beard. BAA has been documented in a select number of studies. We review the literature and discuss the clinical features, epidemiology, diagnosis, and treatment of BAA...
May 29, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28540590/pediatric-psoriasis
#10
REVIEW
Maria Relvas, Tiago Torres
Psoriasis is a chronic inflammatory systemic disease associated with an important physical and physiological burden. It primarily affects the skin, but it is associated with several serious medical co-morbidities. One third of total psoriatic cases have their onset during the pediatric age, although some of them may not be diagnosed until the patient reaches adulthood. Additionally, in the pediatric age, there is an association with several medical co-morbidities; thus, an early recognition of the disease and a subsequent appropriate approach may delay or even prevent considerable co-morbidities...
May 24, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28540589/erratum-to-calcipotriol-plus-betamethasone-dipropionate-aerosol-foam-in-patients-with-moderate-to-severe-psoriasis-sub-group-analysis-of-the-pso-able-study
#11
Carle Paul, Craig Leonardi, Alan Menter, Kristian Reich, Linda Stein Gold, Richard B Warren, Anders Møller, Mark Lebwohl
No abstract text is available yet for this article.
May 24, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28537004/mek-inhibitors-in-the-treatment-of-metastatic-melanoma-and-solid-tumors
#12
REVIEW
Antonio M Grimaldi, Ester Simeone, Lucia Festino, Vito Vanella, Martina Strudel, Paolo A Ascierto
The mitogen-activated protein kinase (MAPK) cascade is an intracellular signaling pathway involved in the regulation of cellular proliferation and the survival of tumor cells. Several different mutations, involving BRAF or NRAS, exert an oncogenic effect by activating the MAPK pathway, resulting in an increase in cellular proliferation. These mutations have become targets for new therapeutic strategies in melanoma and other cancers. Selective MEK inhibitors have the ability to inhibit growth and induce cell death in BRAF- and NRAS-mutant melanoma cell lines...
May 23, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28534318/association-between-inflammatory-skin-disease-and-cardiovascular-and-cerebrovascular-co-morbidities-in-us-adults-analysis-of-nationwide-inpatient-sample-data
#13
Michael C Kwa, Jonathan I Silverberg
BACKGROUND: Psoriasis, atopic dermatitis or eczema (AD-E), pemphigus, bullous pemphigoid (BP), and hidradenitis are chronic inflammatory skin disorders associated with systemic immune activation, considerable symptom burden, stigma, functional disturbances, and mental health symptoms. All of these might increase cardiovascular risk. OBJECTIVE: The objective of this study was to determine whether these inflammatory skin diseases are associated with increased cardiovascular/cerebrovascular risk and/or disease...
May 22, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28510141/sunscreens-an-update
#14
REVIEW
Jennifer Brescoll Mancuso, Rohit Maruthi, Steve Q Wang, Henry W Lim
Sunscreens have been widely used by the general public for their photoprotective properties, including prevention of photocarcinogenesis and photoaging and management of photodermatoses. It is important to emphasize to consumers the necessity of broad-spectrum protection, with coverage of both ultraviolet A (320-400 nm) and ultraviolet B (290-320 nm) radiation. This review discusses the benefits of sunscreen, different ultraviolet filters, sunscreen regulations and controversies, the importance of broad-spectrum protection, issues of photostability and formulation, and patient education and compliance...
May 16, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28508257/diagnosing-allergic-contact-dermatitis-through-elimination-perception-detection-and-deduction
#15
REVIEW
Korbkarn Pongpairoj, Pailin Puangpet, Supitchaya Thaiwat, John P McFadden
Several authors have commented upon the skills of detection required in making a diagnosis of allergic contact dermatitis. Here, we emphasise the search for clues in a systematic manner. We describe four stages as part of a systematic method for diagnosing allergic contact dermatitis. Firstly, elimination (or inclusion) of non-allergic diagnoses. Secondly, perception: the pre-patch test diagnosis and the 'three scenarios' principle. Thirdly, detection: optimising the sensitivity of the patch test process. Fourthly, deduction: diagnosing allergic contact dermatitis by associating the dermatitis with the allergen exposure...
May 15, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28508256/the-role-of-micronutrients-in-alopecia-areata-a-review
#16
REVIEW
Jordan M Thompson, Mehwish A Mirza, Min Kyung Park, Abrar A Qureshi, Eunyoung Cho
Alopecia areata (AA) is a common, non-scarring form of hair loss caused by immune-mediated attack of the hair follicle. As with other immune-mediated diseases, a complex interplay between environment and genetics is thought to lead to the development of AA. Deficiency of micronutrients such as vitamins and minerals may represent a modifiable risk factor associated with development of AA. Given the role of these micronutrients in normal hair follicle development and in immune cell function, a growing number of investigations have sought to determine whether serum levels of these nutrients might differ in AA patients, and whether supplementation of these nutrients might represent a therapeutic option for AA...
May 15, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28488241/onychotillomania-diagnosis-and-management
#17
REVIEW
Pierre Halteh, Richard K Scher, Shari R Lipner
Onychotillomania, defined as self-induced trauma to the nail unit, either by picking or pulling at the nails, affects 0.9% of the population. It may lead to severe irreversible nail dystrophy, melanonychia, or infections. Although no large clinical trials have assessed the efficacy of treatments, cognitive-behavioral therapy, physical barrier methods, and pharmacological treatments have shown some benefits in case reports. The objective of this article is to review the prevalence, diagnostic criteria, etiology, historical and physical examination findings, pathological features, and current treatment methods...
May 9, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28488240/erratum-to-increasing-frequency-of-seborrheic-keratosis-diagnoses-as-a-favorable-consequence-of-teledermatology-based-skin-cancer-screening-a-cross-sectional-study-of-34-553-patients
#18
David Moreno-Ramírez, Jesús Raya-Maldonado, Macarena Morales-Conde, Teresa Ojeda-Vila, Francisco J Martín-Gutiérrez, Andrés Ruíz-de-Casas, Almudena Fernández-Orland, Juan M Herrerías-Esteban, Lara Ferrándiz
No abstract text is available yet for this article.
May 9, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28477309/oral-ulcers-in-juvenile-onset-systemic-lupus-erythematosus-a-review-of-the-literature
#19
REVIEW
Pongsawat Rodsaward, Titipong Prueksrisakul, Tawatchai Deekajorndech, Steven W Edwards, Michael W Beresford, Direkrit Chiewchengchol
Oral ulcers are the most common mucosal sign in juvenile-onset systemic lupus erythematosus (JSLE). The ulcers are one of the key clinical features; however, the terminology of oral ulcers, especially in JSLE patients, is often vague and ill-defined. In fact, there are several clinical manifestations of oral ulcers in JSLE, and some lesions occur when the disease is active, indicating that early management of the disease should be started. Oral ulcers are classified as lupus erythematosus (LE) specific, where the lesional biopsy shows a unique pattern of mucosal change in LE, and LE nonspecific, where the ulcers and their histopathological findings can be found in other oral diseases...
May 5, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28447213/discordance-between-physician-and-patient-reported-disease-severity-in-adults-with-atopic-dermatitis-a-us-cross-sectional-survey
#20
Wenhui Wei, Peter Anderson, Abhijit Gadkari, Stuart Blackburn, Rachel Moon, James Piercy, Shashank Shinde, Jorge Gomez, Eric Ghorayeb
BACKGROUND: There is limited understanding of severity rating of atopic dermatitis in clinical practice. OBJECTIVES: To evaluate the agreement between physician- and patient-rated severity of atopic dermatitis. METHODS: Data were collected from the 2014 Adelphi US Atopic Dermatitis Disease Specific Programme, a cross-sectional survey of physicians and their patients with a history of moderate-to-severe atopic dermatitis; patients voluntarily completed a questionnaire...
April 26, 2017: American Journal of Clinical Dermatology
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