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American Journal of Clinical Dermatology

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https://www.readbyqxmd.com/read/29752702/daylight-photodynamic-therapy-for-actinic-keratoses
#1
REVIEW
Colin A Morton, Lasse R Braathen
Topical photodynamic therapy (PDT) using daylight is effective in the treatment of actinic keratoses (AKs), offering the potential for treatment of large fields such as full face and balding scalp, but with minimal therapy-associated pain. Comparison with conventional PDT indicates similar efficacy for thin and moderate-thickness AKs, but with significantly less discomfort/pain, driving a patient preference for daylight-mediated PDT (DL-PDT) compared with conventional PDT using high-intensity office/hospital-based light sources...
May 11, 2018: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/29744784/acne-scarring-management-systematic-review-and-evaluation-of-the-evidence
#2
REVIEW
Shashank Bhargava, Paulo R Cunha, Jennifer Lee, George Kroumpouzos
BACKGROUND: Modalities for atrophic acne scarring can be classified depending upon the needs they satisfy; that is, resurfacing, lifting/volumization, tightening, or surgical removal/movement of tissue that is required for correction. A plethora of treatment options have resulted from the need to treat various acne scar types, variability of responses noted in various skin types, and increasing popularity of minimally invasive modalities. Still, there is a lack of consensus guidelines on treatment or combination therapies for various clinical scenarios...
May 9, 2018: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/29721816/underlying-systemic-diseases-in-pyoderma-gangrenosum-a-systematic-review-and-meta-analysis
#3
Khalaf Kridin, Arnon D Cohen, Kyle T Amber
BACKGROUND: There is little consensus regarding the prevalence and distribution of underlying systemic diseases among patients with pyoderma gangrenosum. OBJECTIVE: The objective of this study was to synthesize existing data on the prevalence of associated systemic diseases in patients with pyoderma gangrenosum. METHODS: We performed a systematic review and meta-analysis of observational studies in MEDLINE, EMBASE, and Scopus (1823-2017). The quality of evidence was assessed using a modified Newcastle-Ottawa Scale...
May 2, 2018: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/29691768/skin-cancer-following-solid-organ-transplantation-a-review-of-risk-factors-and-models-of-care
#4
REVIEW
Matthew D Howard, John C Su, Alvin H Chong
The number of solid organ transplants has been increasing annually worldwide. Advances in transplantation surgery and community awareness of organ donation have been key contributors. Combined with increased understanding of immunosuppression, there are a growing number of solid organ transplant recipients in the community as a result of improved long-term outcomes. There remains a high incidence of deaths worldwide post-transplant due to non-melanoma skin cancer (NMSC), which has greater morbidity and mortality in this population than in the general community...
April 24, 2018: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/29687361/tildrakizumab-asmn-what-s-in-a-name
#5
Eric J Yang, Kristen M Beck, Wilson Liao
No abstract text is available yet for this article.
April 23, 2018: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/29600394/correction-to-efficacy-and-safety-of-switching-to-ixekizumab-in-etanercept-non-responders-a-subanalysis-from-two-phase-iii-randomized-clinical-trials-in-moderate-to-severe-plaque-psoriasis-uncover-2-and-3
#6
Andrew Blauvelt, Kim A Papp, Christopher E M Griffiths, Luis Puig, Jamie Weisman, Yves Dutronc, Lisa Farmer Kerr, Dapo Ilo, Lotus Mallbris, Matthias Augustin
The article Efficacy and Safety of Switching to Ixekizumab in Etanercept Non-Responders: A Subanalysis from Two Phase III Randomized Clinical Trials in Moderate-to-Severe Plaque Psoriasis (UNCOVER-2 and -3) written by Andrew Blauvelt.
March 29, 2018: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/29594974/emerging-therapies-for-acne-vulgaris
#7
REVIEW
Megha K Trivedi, Suzana S Bosanac, Raja K Sivamani, Larissa N Larsen
As we gain a greater understanding of acne pathogenesis, both new agents as well as new uses for established drugs are being considered for the treatment of acne vulgaris. Multiple clinical trials assessing new formulations or combinations of established acne treatments have been conducted, and novel uses of antimicrobials such as modified diallyl disulfide oxide and nitric oxide are being assessed in clinical trials. There are also a multitude of new therapies currently being studied that target the inflammatory cascade of acne pathogenesis, including sebosuppressive and anti-inflammatory phytochemicals, and  small molecule inhibitors targeting sebaceous glands and enzymes, among others...
March 29, 2018: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/29594973/clinical-and-therapeutic-aspects-of-linear-psoriasis-a-study-of-30-cases
#8
Matthieu Say, Franck Boralévi, Cédric Lenormand, Anne-Claire Bursztejn, Eric Estève, Alice Phan, Emmanuelle Bourrat, Jean-Philippe Lacour, Marie-Aleth Richard, Aurélie Acher, Denis Jullien, Nathalie Beneton, Vincent Descamps, Christine Bodemer, Marion Lagaude, Christine Chiaverini, Emmanuel Mahé
BACKGROUND: Psoriasis affects 2-4% of the population, with the most common clinical type being plaque psoriasis. The linear form of psoriasis is very rare. The literature on linear psoriasis (LP) consists of only case reports, and data are few. OBJECTIVE: This study aimed to better understand LP in a large-scale study. PATIENTS AND METHODS: We retrospectively retrieved the medical records from 14 French medical centers of patients newly diagnosed clinically with LP, with or without the support of histology, between 1 February and 31 July 2015...
March 29, 2018: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/29582369/field-cancerization-therapies-for-management-of-actinic-keratosis-a-narrative-review
#9
REVIEW
Nathan Jetter, Neha Chandan, Stephanie Wang, Maria Tsoukas
Actinic keratoses (AKs) are atypical, precancerous proliferations of keratinocytes that develop because of chronic exposure to ultraviolet (UV) radiation. Treatment of AK can be lesion-directed or field-directed. Field cancerization theory postulates that the skin surrounding AK is also at increased risk for possible malignant transformation since it has been exposed to the same chronic UV light. Field-directed therapies thus have the potential to address subclinical damage, reduce AK recurrence rates, and potentially reduce the risk of squamous cell carcinoma (SCC) development...
March 26, 2018: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/29556985/the-use-of-hormonal-antiandrogen-therapy-in-female-patients-with-acne-a-10-year-retrospective-study
#10
Joyce H Park, Amanda Bienenfeld, Seth J Orlow, Arielle R Nagler
BACKGROUND: Little is known about how dermatologists prescribe hormonal antiandrogen acne treatment (HAAT). OBJECTIVE: The aim of this study was to investigate dermatologists' HAAT-prescribing habits and HAAT's impact on systemic antibiotic use in women with acne. METHODS: We performed a retrospective study at an academic medical center of female patients receiving HAAT (combined oral contraceptive [COC], spironolactone) for acne from January 2005 to October 2015...
March 20, 2018: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/29549588/prevention-and-reduction-of-atrophic-acne-scars-with-adapalene-0-3-benzoyl-peroxide-2-5-gel-in-subjects-with-moderate-or-severe-facial-acne-results-of-a-6-month-randomized-vehicle-controlled-trial-using-intra-individual-comparison
#11
Brigitte Dréno, Robert Bissonnette, Angélique Gagné-Henley, Benjamin Barankin, Charles Lynde, Nabil Kerrouche, Jerry Tan
BACKGROUND: Very few clinical trials have investigated the effect of topical acne treatment on scarring. OBJECTIVES: Our objective was to evaluate the efficacy of adapalene 0.3%/benzoyl peroxide 2.5% gel (A0.3/BPO2.5) in atrophic acne scar formation in patients with acne. METHODS: In this multicenter, randomized, investigator-blinded, vehicle-controlled study, subjects with moderate or severe facial acne (Investigator's Global Assessment [IGA] score 3 or 4; ≥ 25 inflammatory lesions; ten or more atrophic acne scars) applied A0...
March 16, 2018: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/29488102/therapeutics-for-adult-nail-psoriasis-and-nail-lichen-planus-a-guide-for-clinicians
#12
REVIEW
Danielle R McClanahan, Joseph C English
Nail psoriasis (NP) and nail lichen planus (NLP) can be limiting, stigmatizing and difficult to treat. Dermatologists commonly treat psoriasis and lichen planus but when associated onychodystrophy is present or is an isolated finding, some develop apprehension. The goal of this review is to develop therapeutic ladders to be used as a guide for the management of NP and NLP in everyday clinical practice. Evidence-based therapies for NP are robust and range from topical treatments to conventional systemic therapies (i...
February 27, 2018: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/29525933/american-academy-of-dermatology-annual-meeting-san-diego-ca-usa-16-20-feb-2018
#13
Kathy A Fraser
No abstract text is available yet for this article.
April 2018: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/29368043/comparison-of-urticaria-activity-score-over-7-days-uas7-values-obtained-from-once-daily-and-twice-daily-versions-results-from-the-assure-csu-study
#14
Kelly Hollis, Christina Proctor, Doreen McBride, Maria-Magdalena Balp, Lori McLeod, Shannon Hunter, Haijun Tian, Sam Khalil, Marcus Maurer
BACKGROUND: The Urticaria Activity Score summed over 7 days (UAS7) assesses the itch severity and hive count in chronic spontaneous urticaria (CSU) using once- or twice-daily diary-based documentation. OBJECTIVE: The aim of this study was to evaluate the comparability of twice-daily versus once-daily versions of the UAS and the resulting UAS7 values. METHODS: Data came from the ASSURE-CSU study. The twice-daily and once-daily UAS7 was calculated from morning and evening ratings, as well as from exact 24-h evening ratings of hive count and itch severity, respectively...
April 2018: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28994020/vitamin-d-and-the-skin-an-update-for-dermatologists
#15
REVIEW
Elio Kechichian, Khaled Ezzedine
Vitamin D plays a key role in skeletal and cardiovascular disorders, cancers, central nervous system diseases, reproductive diseases, infections, and autoimmune and dermatological disorders. The two main sources of vitamin D are sun exposure and oral intake, including vitamin D supplementation and dietary intake. Multiple factors are linked to vitamin D status, such as Fitzpatrick skin type, sex, body mass index, physical activity, alcohol intake, and vitamin D receptor polymorphisms. Patients with photosensitive disorders tend to avoid sun exposure, and this practice, along with photoprotection, can put this category of patients at risk for vitamin D deficiency...
April 2018: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/29453712/author-correction-to-psoriasis-in-skin-of-color-insights-into-the-epidemiology-clinical-presentation-genetics-quality-of-life-impact-and-treatment-of-psoriasis-in-non-white-racial-ethnic-groups
#16
Bridget P Kaufman, Andrew F Alexis
In the original publication, section 5, paragraph 1 was incorrectly published.
February 16, 2018: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/29417399/melanoma-brain-metastases-local-therapies-targeted-therapies-immune-checkpoint-inhibitors-and-their-combinations-chances-and-challenges
#17
REVIEW
Marvin Kuske, Ricarda Rauschenberg, Marlene Garzarolli, Michelle Meredyth-Stewart, Stefan Beissert, Esther G C Troost, Oliva Isabella Claudia Glitza, Friedegund Meier
Recent phase II trials have shown that BRAF/MEK inhibitors and immune checkpoint inhibitors are active in patients with melanoma brain metastases (MBM), reporting intracranial disease control rates of 50-75%. Furthermore, retrospective analyses suggest that combining stereotactic radiosurgery with immune checkpoint inhibitors or BRAF/MEK inhibitors prolongs overall survival. These data stress the need for inter- and multidisciplinary cooperation that takes into account the individual prognostic factors in order to establish the best treatment for each patient...
February 7, 2018: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/29396702/a-phase-ii-randomized-double-blind-clinical-study-evaluating-the-safety-tolerability-and-efficacy-of-a-topical-minocycline-foam-fmx103-for-the-treatment-of-facial-papulopustular-rosacea
#18
Ulrich Mrowietz, Tal Hetzroni Kedem, Rita Keynan, Meir Eini, Dov Tamarkin, Dror Rom, Mitchell Shirvan
OBJECTIVE: Our objective was to demonstrate the safety, tolerability, and efficacy of a minocycline foam, FMX103, in the treatment of moderate-to-severe facial papulopustular rosacea. METHODS: This was a phase II, randomized, double-blind, multicenter study. Healthy subjects aged ≥ 18 years with moderate-to-severe rosacea that had been diagnosed ≥ 6 months previously and with ≥ 12 inflammatory facial lesions were randomized (1:1:1) to receive once-daily 1...
February 2, 2018: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/29392620/treatment-of-autoimmune-bullous-disorders-in-pregnancy
#19
REVIEW
Carolyn J Kushner, Josef Symon S Concha, Victoria P Werth
Autoimmune bullous diseases (AIBD), including pemphigus, bullous pemphigoid, epidermolysis bullosa acquisita, mucous membrane pemphigoid, and pemphigoid gestationis, pose significant therapeutic challenges, especially in pregnant and post-partum breastfeeding patients or those planning to conceive. Data on the safety and efficacy of therapeutic interventions during the perinatal period are lacking because randomized controlled trials are typically not performed in this setting. However, many of the treatments for AIBD are also used in other diseases, so data can be extrapolated from studies or case reports in these other patient populations...
February 2, 2018: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/29340955/adult-atopic-dermatitis-is-associated-with-increased-aortic-stiffness
#20
LETTER
Győző Szolnoky, Anita Altmayer, József Varga, Henriette Gavallér, Lajos Kemény, Tamás Forster, Attila Nemes
No abstract text is available yet for this article.
February 2018: American Journal of Clinical Dermatology
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