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Japanese Journal of Infectious Diseases

Fernando Cobo, Javier Rodríguez-Granger, Antonio Sampedro, José Gutiérrez-Fernández, José María Navarro-Marí
Trueperella bernardiae is a Gram-positive curved rod that is considered an uncommon pathogen involved in few infections. The true incidence of infections with this bacterium as well as the clinical implications are still unknown. We report two cases of wound infections in two patients that underwent different surgical procedures, although in the second case the microorganism was isolated in mixed culture. Culture of wound secretion resulted on T. bernardiae isolation. Treatment was performed and resolution of these infections were documented...
September 11, 2017: Japanese Journal of Infectious Diseases
Takehiro Hashimoto, Satoshi Kutsuna, Takahiro Maeki, Shigeru Tajima, Saho Takaya, Yuichi Katanami, Kei Yamamoto, Nozomi Takeshita, Kayoko Hayakawa, Yasuyuki Kato, Shuzo Kanagawa, Norio Ohmagari
Dengue fever remains underreported in Africa due to lack of awareness among healthcare providers, the presence of other febrile illnesses, and insufficient laboratory testing. We present a case of imported dengue fever from Burkina Faso to Japan, where an outbreak of dengue was reported on October 18, 2016. The phylogenetic analysis revealed that the isolate from our patient belonged to a distinct of sylvatic dengue viruses, suggesting that dengue viruses have been maintained in the mosquitoes and human cycles in Burkina Faso for more than 30 years...
September 11, 2017: Japanese Journal of Infectious Diseases
Shizuka Tanaka, Yohei Matoba, Maki Unno, Tatsuya Ikeda, Tsutomu Itagaki, Katsumi Mizuta
No abstract text is available yet for this article.
September 11, 2017: Japanese Journal of Infectious Diseases
Sawitree Nuramrum, Aroonwadee Chanawong, Kamonwan Lunha, Aroonlug Lulitanond, Arunnee Sangka, Chotechana Wilailuckana, Sunpetch Angkititrakul, Nicha Charoensri, Lumyai Wonglakorn, Prajuab Chaimanee, Ploenchan Chetchotisakd
Twelve non-replicate carbapenemase-negative ertapenem-non-susceptible (CNENS) Escherichia coli isolates from a Thai university hospital between 2010 and 2014 were characterized and compared with two carbapenemase-producing E. coli isolates from the same hospital. Eight unique PFGE patterns were obtained. All produced CTX-M-15 β-lactamase and two isolates co-expressed either CMY-2 cephalosporinase or increased efflux pump. Amino acid sequence analysis revealed that OmpF defect (seven isolates) due to mutations generating premature proteins or an IS1 insertion was more prevalent than in OmpC (no truncated proteins found)...
September 11, 2017: Japanese Journal of Infectious Diseases
Wataru Yamazaki, Islam Ibrahim Sabike, Satoshi Sekiguchi
No abstract text is available yet for this article.
September 11, 2017: Japanese Journal of Infectious Diseases
Hiroshi Yoshikura, Fumihiko Takeuchi
 In norovirus and Campylobacter food poisonings, the frequencies of the number of patients per incident and that of the number of eaters per incident followed lognormal distribution, and their respective medians were 12~27 and 23~48 for norovirus food poisoning and 5~8 and 9~21 for Campylobacter food poisoning. The lognormal frequency distribution of eaters could be simulated by assuming that people are attracted more to a dish that has already attracted many. The number of patients per incident and that of eaters per incident were not necessarily inter-correlated; the frequencies of the attack rates (number of patients/number of eaters) were distributed evenly from ~0...
September 11, 2017: Japanese Journal of Infectious Diseases
Yoshikazu Mutoh, Nobuo Koizumi, Eriko Morino, Kayoko Hayakawa, Yasuyuki Kato, Norio Ohmagari
In Japan, 20-50 cases of leptospirosis are reported annually, typically involving farmers or returnees from tropical areas. Here, we report five indigenous leptospirosis cases that occurred in the Tokyo urban area. All cases were male (mean age 65.8 ± 4.7 years) and presented with clinical features including high fever, acute kidney injury, and jaundice. Three cases presented with pulmonary infiltration and ground glass opacity on admission. Two of the five patients were intubated and underwent continuous hemodiafiltration...
September 11, 2017: Japanese Journal of Infectious Diseases
Qian Tang, Yanfang Zhao, Boxuan Xu, Ping Gong, Di Wang
 Oxazolidinones comprise a novel class of antimicrobials as inhibitors of bacterial ribosomal protein synthesis. In the present study, we identified 15 novel oxazolidinone analogues with potent antituberculosis activities. Compounds sy124 and sy125 displayed the best antituberculosis activity in vitro, against various clinically relevant bacterial species, including most Gram positive bacteria, Mycobacterium and Helicobacter pylori, which are better than that of the linezolid. Cell based assay indicated that these compounds showed strong ability to kill the intracellular pathogens...
September 11, 2017: Japanese Journal of Infectious Diseases
Liu Ming, Jian-An Huang
OP-145 is a synthetic antimicrobial peptide developed from the human cathelicidin LL-37. The purpose of this investigation was to evaluate the effect of the antimicrobial peptide OP-145 against clinically isolated drug resistant strains. Ten Methicillin-resistant Staphylococcus aureus (MRSA) strains were obtained from our hospital's clinical inspection center and the activity of OP-145 on growth and biofilm formation on these strains was evaluated by colony counts and scanning electron microscopy. The antimicrobial peptide OP-145 showed significant antibacterial activity against 9 MRSA strains...
September 11, 2017: Japanese Journal of Infectious Diseases
Shetty Pooja, Sasidharanpillai Sabeena, Bhaskar Revti, Ramachandran Sanjay, Aithal Anjali, Kumar Rajendra, Sushama Aswathyraj, Dsouza Giselle, Maity Hindol, Govindakarnavar Arunkumar
Dengue is found to be the most prevalent arboviral disease affecting humans. Tropical and subtropical regions are at high risk of dengue virus infections. The clinical manifestations often range from mild fever to fever with hemorrhagic manifestations and shock. Since 2010, India is witnessing a marked increase in the number of Dengue Virus Serotype 1(DENV-1) apart from Dengue Virus 2 (DENV-2) and Dengue Virus 3 (DENV-3) Serotypes. The present study was undertaken to understand the circulating genotypes of DENV-1 in South West India by sequencing the envelope gene of DENV-1 samples representative of the time period 2014-2015...
September 11, 2017: Japanese Journal of Infectious Diseases
Yuka Yamagishi, Tatsuya Shibata, Satoshi Nakagawa, Nobuhiko Nomura, Junichi Mitsuyama, Hiroshige Mikamo
The pharmacokinetic-pharmacodynamic (PK-PD) breakpoints (BPs) of garenoxacin (GRNX) and other oral quinolones were calculated using the Monte Carlo simulation (MCS) based on the distribution of changes in their plasma concentrations. PK-PD BPs of 400 mg once a day (QD) of GRNX for the free area under the curve/minimum inhibitory concentration (fAUC/MIC) for 30 of Streptococcus pneumoniae and 100 of Gram-negative bacteria: (G (-)) were 0.5 and 0.125 μg/mL, respectively. PK-PD BPs of other quinolones for S. pneumoniae/G(-) were 1/0...
September 11, 2017: Japanese Journal of Infectious Diseases
Shahla Afrasiabian, Behzad Mohsenpour, Ebrahim Ghaderi, Sara Nadri, Katayon Hajibagheri
Brucellosis is endemic in Iran. Several studies show that brucellosis is associated with other infectious diseases. This study aimed to determine the relationship between brucellosis and Helicobacter pylori. In this case-control study, 100 patients with brucellosis as ceases and 200 participants without brucellosis as controls were evaluated. To compare the prevalence of Helicobacter pylori in the two groups, odds ratio and confidence intervals for every variable were analyzed through using logistic regression model after adjustment for confounding factors...
September 11, 2017: Japanese Journal of Infectious Diseases
Satoshi Hiroi, Saeko Morikawa, Keiko Nakata, Tetsuo Kase
Human adenovirus (HAdV) strains isolated from respiratory specimens of 139 children between 2008 and 2015 were analyzed with the intent of evaluating the endemic situation of HAdV infections in Osaka, Japan. The cases increased in spring and winter, and the infections were confirmed mainly in children aged ≤ 5 years, comprising 91.9% of the total population examined. Molecular typing of the isolates revealed that the most common types belonged to HAdV-B and HAdV-C, and a case of co-infection with HAdV-C1 and HAdV-C2 was confirmed...
September 11, 2017: Japanese Journal of Infectious Diseases
Lipika Singhal, Varsha Gupta, Vibha Mehta, Nidhi Singla, A K Janmeja, Jagdish Chander
No abstract text is available yet for this article.
September 11, 2017: Japanese Journal of Infectious Diseases
Akihiro Ito, Tadashi Ishida, Hiromasa Tachibana, Yuhei Ito, Takuya Takaiwa, Hiroyuki Fujii, Toru Hashimoto, Hiroshi Nakajima, Junko Amemura-Maekawa
Legionella species are important causative pathogens for severe community-acquired pneumonia (CAP). Most cases of Legionella pneumonia are due to Legionella pneumophila serogroup 1, and CAP due to Legionella pneumophila serogroup 9 is rare. A fourth case of CAP due to Legionella pneumophila serogroup 9 is reported, and initial treatment using single-dose oral azithromycin appeared useful. Azithromycin injection or fluoroquinolone injection is usually recommended for the treatment of Legionella pneumonia, and no previous reports have shown the effectiveness of single-dose oral azithromycin...
September 11, 2017: Japanese Journal of Infectious Diseases
Hung Thai Do, Dong Thanh Nguyen, Lan Anh Thi Nguyen, Duong Huy Do, Huy Xuan Le, Xuan Mai Thi Trinh, Hong Vy Nu Ton, Ikumi Sawada, Noriko Kitamura, Nhat Minh Le, Keisuke Yoshihara, Thu Huong Thi Phan, Chien Trong Bui, Koya Ariyoshi, Lay Myint Yoshida
We investigated the prevalence of HIV drug resistance among high risk groups such as injecting drug user (IDU), female sex worker (FSW) and men having sex with men (MSM) in central Vietnam. We used HIV positive samples from 2012-2013 sentinel surveillance surveys. Study subjects were screened for HIV infection by standardized screening assays and the positive samples were further tested for HIV viral load and drug resistant mutations by in-house assays. Drug resistant mutations (DRMs) were determined using the Stanford University online sequence analysis tool...
September 11, 2017: Japanese Journal of Infectious Diseases
Shao-Ming Chen, Li Qiu, Zhong-Hua Du, Yu-Ming Jin, Jian-Wei Du, Yan Chen, Chiho Watanabe, Masahiro Umezaki
  The incidence of severe Hand-Foot-Mouth disease (HFMD) in Southeast/East Asia has recently increased. This study explored spatial clusters of the incidence and proportion of severe HFMD cases in Hainan Island, Where the prevalence and mortality of HFMD were the highest in China in 2011. A spatial autocorrelation statistic (Anselin's Local Moran I) was calculated for the Empirical Bayesian (EB) smoothed dataset of severe HFMD cases. Significantly spatial clusters were detected for both incidence and the proportion of severe HFMD cases...
September 11, 2017: Japanese Journal of Infectious Diseases
Chutatip Limkunakul, Palakorn Srinithiwat, Busaraporn Lochinda, Kittisak Sawanyawisuth
Chronic kidney disease (CKD) has been shown to be a poor prognostic factor in HIV patients. This study aimed to find risk factors in HIV-infected patients with early decline renal function or less than 90 ml/min/1.73m(2). The study was retrospective conducted at Chonprathan Hospital, Thailand. The inclusion criteria were HIV-infected adult patients who were treated at the hospital's HIV clinic and whose eGFR levels at the first visit had been evaluated. Eligible patients were categorized by eGFR level at 90 ml/min/1...
September 11, 2017: Japanese Journal of Infectious Diseases
Kentaro Fujita, Seishiro Naito, Masaki Ochiai, Toshifumi Konda, Atsushi Kato
Many countries have established their own vaccine lot release system, which fits each country's situation, while the World Health Organization is promoting convergence in regulatory systems for vaccines so that vaccines of assured quality are provided globally. We conducted questionnaire-based investigation of the lot release systems for vaccines in seven countries and two regions. It was found that a review of the summary protocol by National Regulatory Authorities was commonly applied for independent lot release of vaccines, whereas there was diversity, especially in the testing policy...
July 1, 2017: Japanese Journal of Infectious Diseases
Shuji Suzuki, Tomoko Kawamura, Yusuke Saeki, Mika Okubo, Masami Konagaya, Nozomu Hanaoka, Takeshi Arashiro, Tsuguto Fujimoto, Eiichi Uchio
No abstract text is available yet for this article.
July 1, 2017: Japanese Journal of Infectious Diseases
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