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Japanese Journal of Infectious Diseases

Trang Thi Thu Pham, Xiuqiong Bi, Huyen Thi Thanh Hoang, Azumi Ishizaki, Mai Thi Phuong Nguyen, Cuong Hung Nguyen, Hung Phi Nguyen, Thuc Van Pham, Hiroshi Ichimura
We previously reported human papillomavirus type 52 (HPV52) as the most prevalent high-risk genotype in non-cancer individuals in Vietnam. This study aimed to evaluate HPV genotypes and HPV16 E6 and E7 (E6/E7) gene variations in Vietnamese patients with genital cancers. Biopsy samples were collected from 124 Vietnamese patients with genital cancers (20 with vaginal, 50 with vulvar, and 54 with penile cancer). The HPV-DNA was amplified and genotyped, and HPV16 E6/E7 genes were compared with those previously reported for women with a normal cervical cytology (N=23)...
June 29, 2018: Japanese Journal of Infectious Diseases
Takahiro Maeki, Shigeru Tajima, Aung Kyaw Kyaw, Fumiaki Matsumoto, Kana Miura, Ayaka Yamashita, Akira Yoshikawa, Kodai Negishi, Yuji Noguchi, Koh Tadokoro, Koji Abe, Junko Taruya, Jinsoo Koh, Hidefumi Ito, Asaka Ikegaya, Fuyuki Abe, Mieko Wada, Tsuyoshi Nishigata, Makiko Ikeda, Fumihiro Kato, Satoshi Taniguchi, Eri Nakayama, Tomohiko Takasaki, Kouichi Morita, Chang-Kweng Lim, Masayuki Saijo
Japanese encephalitis (JE) is an acute viral disease caused by the Japanese encephalitis virus (JEV). JEV strains are classified into five genotypes (I-V). JEV genotype V strains have never been detected in Japan to date, but they have been recently detected in South Korea. In the present analysis, we tried to determine if a JEV genotype V strain caused any JE case in Japan in 2016. The serum and cerebrospinal fluid samples were collected from 10 JE patients reported in Japan in 2016. JEV RNA was not detected in any of the samples...
June 29, 2018: Japanese Journal of Infectious Diseases
Kenichi Komabayashi, Junji Seto, Shizuka Tanaka, Yu Suzuki, Tatsuya Ikeda, Noriko Onuki, Keiko Yamada, Tadayuki Ahiko, Hitoshi Ishikawa, Katsumi Mizuta
Modified measles (M-Me), characterized by milder symptoms than typical measles (T-Me), has been increasing in Japan, but M-Me dominated outbreak has not been investigated sufficiently worldwide. During March-April 2017, there was the largest importation-related outbreak of measles with genotype D8 in Yamagata, Japan, after Japan had achieved measles elimination in 2015. We confirmed 60 cases by detecting measles virus (MeV) genome, among whom 38 M-Me and 22 T-Me cases were identified. Thirty-nine cases (65...
June 29, 2018: Japanese Journal of Infectious Diseases
De-Qing Yin, Chuan-Bao Wang, Xiao-Zhou, Sheng-Xiang Ji
In China, a rapid expansion of Hand, foot, and mouth disease (HFMD) outbreaks has occurred since 2004 and HFMD has become an important issue for China. There are more than 20 types of enterovirus causing HFMD, of which Coxsackievirus A16 (CA16) and enterovirus 71 (EV71) are the most common. To analyze the epidemiological characteristics of HFMD caused by EV71 and CA16 in Linyi, Shandong province, China from 2009 to 2017. 5324 stool specimens or throat samples were collected from 5324 HFMD cases for nucleic acid detection of enterovirus...
June 29, 2018: Japanese Journal of Infectious Diseases
Fazilet Duygu, Tugba Sari, Ozgur Gunal, Sener Barut, Ayfer Atay, Feyza Aytekin
Crimean-Congo haemorrhagic fever (CCHF) is a viral zoonotic disease. We aimed here in this study to investigate the cutaneous manifestations of CCHF and reveal their associations with fatality. Two hundred and sixty-nine patients diagnosed with CCHF were recorded. Skin findings were seen in 170 (63.1%) patients. A facial rash was most common cutaneous finding (82 (30.4%)). In the severe cases, haemorrhagic cutaneous manifestations (petechiae and ecchymoses) were recognised. A statistically significant correlation was obtained between the cutaneous manifestations and fatality, and it was determined that there was a strong positive correlation between the fatality and ecchymosis (r=567, p<0...
June 29, 2018: Japanese Journal of Infectious Diseases
Arman Abeev, Assylbek Zhylkibayev, Dinara Kamalova, Nadezhda Kusheva, Gauhar Nusupbaeva, Nazim Tleumbetova, Manar Smagul, Sarkit Beissenova, Saltanat Aubakirova, Zhuldiz Kassenova, Balzira Demessinova, Altay Amanbayev, Yerlan Ramankulov, Alexander Shevtsov
This study was addressed to epidemiological surveillance of measles virus (MV) in the territory of Republic of Kazakhstan during 2015 - 2016 years. In our study we have detected D8 genotype of MV occurred in outbreak season of measles disease. Totally 2341 cases were registered and 19 of them were identified by genotyping. As a result, 16 samples attributed to subgroup A of D8 genotype, and 3 import cases were represented by B3 and H1 genotype of MV. Vaccination coverage analysis showed that large group of infected people were not vaccinated and did not have a reliable report on vaccination status...
June 29, 2018: Japanese Journal of Infectious Diseases
Ki-Hyun Cho, Seung-Yong Park, Won-Chang Lee, Myeong-Jin Lee, Joong-Bok Lee
We undertook analysis of reported dengue fever (DF) cases and DF-relevant characteristics in South Korea from 2006 to 2015. A total of 1,260 DF notifications occurred in the study period were presumedly introduced from endemic foreign countries. The nationwide cumulative incidence rate (CIR) of DF was 0.25 per 100,000 populations; the cumulative incidence rate of DF among overseas travelers was 0.93. CIRs of overseas male and female travelers were 1.13 and 0.87, respectively. CIR of overseas travelers of 20 to 39 years old was highest...
June 29, 2018: Japanese Journal of Infectious Diseases
Nozomi Imanishi, Yukiko Higa, Hwa-Jen Teng, Toshihiko Sunahara, Noboru Minakawa
Anopheles (Anopheles) lindesayi Giles consists of five subspecies. From Japan, only one subspecies, An. l. japonicus Yamada, has been recorded; its geographical populations are morphologically diverse, however, they are regarded as a single subspecies. In this study, we re-evaluated the taxonomic status of An. l. japonicus in Japan and another subspecies, An. l. pleccau distributed in Taiwan, by comparative morphological and molecular analyses based on gene sequences of mitochondrial DNA cytochrome oxidase I (COI) and ribosomal DNA internal transcribed spacer 2 (ITS2)...
June 29, 2018: Japanese Journal of Infectious Diseases
Hande Celiker, Haluk Kazokoglu, Muhsin Eraslan, Eren Cerman, Levent Karabas
Cat-scratch disease (CSD) is a syndrome which is characterized by lymphadenopathy, fever, and skin lesions in association with a cat scratch or bite. Bartonella henselae is the primary bacterial agent responsible for CSD. Here we report serologically proven atypical presentation cases of B henselae neuroretinitis. In this study, three neuroretinitis patients were evaluated. Animal contact histories, ocular examinations, systemic work-up, clinical findings, and treatment compliance of the patients were assessed...
June 29, 2018: Japanese Journal of Infectious Diseases
Yusuke Watanabe, Takehito Kobayashi, Itaru Nakamura, Hiroaki Fujita, Midori Shimoinaba, Shinji Fukushima, Yoshitsugu Miyazaki, Tetsuya Matsumoto
We report the first case of invasive ophthalmologic infection by Acrophialophora sp. that was successfully treated using voriconazole (VRCZ). Acrophialophora spp., which has been reported to be an opportunistic pathogen, is rare thermotolerant soil fungus, but its pathogenicity remains unclear. A 77-year-old man had neutropenia and prostate carcinoma, and was receiving hemodialysis. His right eye had been infected for 2 days. His conjunctiva was congested and partially formed an abscess. Liposomal amphotericin B (L-AMB) was administered following systemic itraconazole...
June 29, 2018: Japanese Journal of Infectious Diseases
Shinji Fukushima, Hitoshi Kikuchi, Mitsunobu Miyazu, Atsuo Hamada, Kazunobu Ouchi, Hiroki Takagi, Hanako Mihara, Toru Sasaki, Hayato Oka, Valerie Bosch-Castells, Philipp Oster
Meningococcal disease can cause significant disability and mortality. The quadrivalent meningococcal polysaccharide diphtheria toxoid conjugate vaccine (Men-ACWY-D) protects against invasive meningococcal disease caused by serogroups A, C, W, and Y. This phase III, open-label, single-arm, multicenter study evaluated the safety and immunogenicity of a single vaccine dose in healthy Japanese adults. The study enrolled 200 participants 2-55 years of age. Immunogenicity was assessed by quantifying seroprotection rates (the proportion of participants with antibody titers ≥1:128 against capsular polysaccharide from all 4 serogroups, measured 28 days after vaccination)...
June 29, 2018: Japanese Journal of Infectious Diseases
Takuya Inagaki, Masaaki Satoh, Hikaru Fujii, Souichi Yamada, Miho Shibamura, Tomoki Yoshikawa, Shizuko Harada, Haruko Takeyama, Masayuki Saijo
Several cases of herpes simplex encephalitis (HSE) caused by acyclovir (ACV)-resistant herpes simplex virus type 1 (HSV-1) have been reported. Amino acid substitutions of R41H, Q125H, and A156V in the viral thymidine kinase (vTK) gene were reported to confer ACV-resistance. Recombinant HSV-1 clones with each amino acid substitution in the vTK were generated using the bacterial artificial chromosome (BAC) system. A recombinant HSV-1 with the substitution of Q125H showed ACV-resistance, while those of R41H or A156V were sensitive to ACV...
May 31, 2018: Japanese Journal of Infectious Diseases
Kyung-Hee Park, Yeon-Joo Choi, Jeoungyeon Kim, Hye-Jin Park, Dayoung Song, Won-Jong Jang
Using Borrelia isolated from South Korea, we evaluated by MLST and three intergenic genes (16S rRNA, ospA, and 5S-23S IGS) typing to analyze the relationship between host and vector and molecular background. Using the MLST analysis, we identified B. afzelii, B. yangtzensis, B. garinii, and B. bavariensis. This study was first report of the identification of B. yangtzensis using the MLST in South Korea.
May 31, 2018: Japanese Journal of Infectious Diseases
Evangelia Sarikloglou, Anastasia Goula, Charalampos Sidiropoulos, Maria Tsolia, Anna Papa
We report a case of murine typhus in a 4-year-old boy living in northern Greece. Although the illness started with mild symptoms, maculopapular rash was presented at the end of the first week of illness followed by marked thrombocytopenia. The detection of IgM antibodies against Rickettsia typhi and a positive PCR result in blood combined by sequencing confirmed the diagnosis of infection by Rickettsia typhi. Clinicians in northern Greece should be aware of the disease, even in cases presented with no specific initial symptoms...
May 31, 2018: Japanese Journal of Infectious Diseases
S Aswathyraj, Sasidharanpillai Sabeena, Kamalakshi G Bhat, Kiran Chandra Bharani, Ramachandran Sanjay, Govindakarnavar Arunkumar
No abstract text is available yet for this article.
May 31, 2018: Japanese Journal of Infectious Diseases
Yoshinori Mitsui, Kentaro Kato
The possible emergence of praziquantel (PZQ)-tolerant and/or resistant schistosomes urgently necessitates the study and development of new antischistosomal drugs as alternatives to PZQ. The aim of the present study was to investigate the capacity of three dyes, namely methylene blue (MB), neutral red (NR) and trypan blue (TB), for the assessment of the in vitro antischistosomal effect of antimalarial drugs on Schistosoma mansoni adult worms. S. mansoni adult worms were incubated in a medium alone for control or supplemented with 10 μg/ml primaquine (PQ), artesunate (AR) and amodiaquine (AQ) for five days...
May 31, 2018: Japanese Journal of Infectious Diseases
Yuko Yoshikawa, Yoshitsugu Ochiai, Mariko Mochizuki, Takashi Takano, Ryo Hondo, Fukiko Ueda
To assess the level of Listeria monocytogenes contamination of domestic retail meat in Tokyo, Japan, we compared isolates from 2004 to 2007 with those isolated before 2003. The overall prevalence of L. monocytogenes among these samples significantly diminished over time (1998-2003, 28.0%; 2004-2007, 17.6%) reflecting a significant decrease in the frequency of contamination of beef. Serotype 1/2a was isolated most frequently, reflecting a change in the predominant serotype in pork from 1/2c to 1/2a. We performed a simple genetic subtyping method based on three genes, iap, sigB, and actA, as well as traditional multilocus sequence typing to classify the allele types (ATs)...
May 31, 2018: Japanese Journal of Infectious Diseases
Konstantinos Fragkiadakis, Petros Ioannou, John A Papadakis, Adam Hatzidakis, Achilleas Gikas, Diamantis P Kofteridis
Cytomegalovirus (CMV) rarely causes disease in immunocompetent individuals but may cause severe disease in immunocompromised patients. We report the case of a multi-transfused, splenectomized young woman due to homozygous β-thalassemia that presented with prolonged fever and respiratory distress. Although broad-spectrum antibiotic therapy had initially been applied, the patient was clinically deteriorated. Serology and molecular blood testing established CMV infection and viremia. Computed tomography of the chest demonstrated pneumonitis and she was successfully treated with 3 weeks ganciclovir...
May 31, 2018: Japanese Journal of Infectious Diseases
Kayoko Hayakawa, Maki Nagashima, Kaichi Ohta, Norio Ohmagari, Niro Tayama
Fusobacterium necrophorum has recently been suggested to be associated with tonsillopharyngitis, peritonsillar abscess, and recurrent tonsillitis. Among the 2 subspecies of F. necrophorum, subsp. funduliforme is known to be a major human pathogen. To better understand the epidemiology of F. necrophorum subsp. funduliforme (FNSF), we studied the prevalence of FNSF in the tonsils of patients undergoing elective tonsillectomy (TE) for different indications. Adult patients who underwent elective TE from October 2014 to November 2015 were included...
May 31, 2018: Japanese Journal of Infectious Diseases
Hidenori Matsunaga, Akio Fukumori, Kohji Mori, Tomoyuki Honda, Takeshi Uema, Keizo Tomonaga
While we had previously detected anti-bornavirus antibodies via radioligand assay in psychiatric patients, we had not examined the viral pathogenicity in these individuals. Herein, we present two psychiatric patients who were seropositive for bornavirus and whose treatment-resistant symptoms improved by oral administration of ribavirin, a broad-spectrum antiviral agent. Cerebrospinal fluid analysis indicated that the ribavirin affected the central nervous system of these patients. Ribavirin ameliorated intermittent involuntary head shaking, which is reminiscent of a symptom observed in bornavirus-infected animals...
May 31, 2018: Japanese Journal of Infectious Diseases
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