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Epilepsy & Behavior: E&B

Patricia Rzezak, Sylvie Paes Moschetta, Melanie Mendonça, Maria Luisa Maia Nobre Paiva, Ana Carolina Coan, Carlos Guerreiro, Kette Dualibi Ramos Valente
Executive deficits and impulsiveness are extensively reported in juvenile myoclonic epilepsy (JME). Previous literature suggests that intelligence may mediate these deficits. In this study, we evaluated and compared the performance of adults with JME with high and low intelligence quotient (IQ) and controls on tasks for executive function (EF) and impulsive traits. We investigated the neuropsychological performance of 53 adults with JME and below average IQ (57% women; 26.9 [±7.88] years; mean IQ: 89.8 [±5...
July 13, 2018: Epilepsy & Behavior: E&B
Giuliano Avanzini
No abstract text is available yet for this article.
July 13, 2018: Epilepsy & Behavior: E&B
Chizuko Nagamori, Keiko Hara, Yuka Hirose, Katsuya Ohta, Miho Akaza, Yuki Sumi
BACKGROUND: Public attitudes and stigma toward epilepsy may limit people with epilepsy (PWE) in seeking treatment and participating in social activities. The prevalence of epilepsy is approximately 0.8% in Japan, similar to rates reported in other countries. Although epilepsy is relatively common, few studies have investigated public awareness about epilepsy in Japan. Recently, several serious car accidents in Japan involving PWE resulted in pedestrian fatalities. Traffic accidents involving PWE have been reported extensively and repeatedly in the media since 2011...
July 12, 2018: Epilepsy & Behavior: E&B
James W Wheless, Andrew J Gienapp, Phillippe Ryvlin
Epilepsy affects millions of people worldwide. Approximately one-third have pharmacoresistant epilepsy, and of these, the majority are not candidates for epilepsy surgery. Vagus nerve stimulation (VNS) therapy has been an option to treat pharmacoresistant seizures for 30 years. In this update, we will review the clinical data that support the device's efficacy in children, adolescents, and adults. We will also review its side-effect profile, quality of life and cost benefits, and the impact the device has on sudden unexpected death in epilepsy (SUDEP)...
July 12, 2018: Epilepsy & Behavior: E&B
Erik Saetre, Michael Abdelnoor
OBJECTIVE: The aim of the study was to summarize the pooled incidence rate of sudden unexpected death in epilepsy (SUDEP) in patients. Meta-regression analysis was applied to identify factors influencing the incidence rate. DESIGN: The study was a systematic review and critical appraisal with a meta-analysis of cohort studies, both prospective and retrospective. MATERIAL AND METHOD: In a literature search, a total of 45 cohort studies were identified...
July 12, 2018: Epilepsy & Behavior: E&B
María Crespo, David Agustín León-Navarro, Mairena Martín
Febrile seizures (FS) represent one of the most frequent convulsive disorders in children which can be classified into simple and prolonged depending on the duration. Although simple FS are generally considered as benign, there is controversy about the outcome of prolonged FS. Here, we have used an animal model of prolonged FS to investigate persistent neurochemical and behavioral alterations in adult rats. Hyperthermic seizures were induced in 12-day-old rats using a warmed air stream from a hair dryer. Neonates exhibited arrest of heat-induced hyperkinesis followed by body flexion and rearing and falling over associated with hindlimb clonus seizures (stage 5 on Racine scale criteria) after hyperthermic induction...
July 12, 2018: Epilepsy & Behavior: E&B
Senem Sezikli, Tuğba Argün Pulat, Betül Tekin, Pelin Doğan Ak, Cahit Keskinkılıç, Dilek Ataklı
PURPOSE: The study aimed to examine the relationship between frontal lobe functions and interictal electroencephalography (EEG) discharge characteristics of patients with juvenile myoclonic epilepsy (JME). METHOD: Thirty patients with JME who had EEG with asymmetrical generalized discharge (aEEG), 15 patients with JME who had EEG with symmetrical generalized discharge (sEEG), and 15 healthy controls were included in the study. To evaluate attention, the digit span and Corsi block tests were used; to evaluate memory, we applied verbal and visual memory tests; to evaluate frontal lobe functions, we used clock drawing, verbal fluency, the Stroop test, trail making, mental control, and antisaccadic eye movement tests as well as the continuous performance (CPT) tests...
July 12, 2018: Epilepsy & Behavior: E&B
Ya-Yu Chen, Sha Huang, Wen-Yue Wu, Chao-Rong Liu, Xiao-Yan Yang, Hai-Ting Zhao, Ling-Chao Wu, Lang-Zi Tan, Li-Li Long, Bo Xiao
OBJECTIVE: Identifying the factors that are correlated with and predictive of reduced quality of life (QOL) is essential to optimize the treatment of epilepsy and the management of comorbidities. METHODS: We analyzed the independent associations between the Quality of Life in Epilepsy-31 (QOLIE-31) inventory and the demographic, clinical, psychiatric, and cognitive variables of 47 consecutive patients with temporal lobe epilepsy (TLE). Predictors of the correlated variables were analyzed by multiple linear regression analysis...
July 12, 2018: Epilepsy & Behavior: E&B
Charlotte Young, Rohit Shankar, William Henley, Adam Rose, Katie Cheatle, Josemir W Sander
BACKGROUND: Sudden unexpected death in epilepsy (SUDEP) is a leading cause of death among people with chronic epilepsy. People with intellectual disability (ID) are overrepresented in this population. The SUDEP and Seizure Safety Checklist ("Checklist") is a tool to discuss risk factors influencing seizures and the risk of SUDEP. It includes questions about the availability of nocturnal monitoring. In Cornwall UK, people with epilepsy and ID and their relatives and carers are routinely advised to consider nocturnal surveillance to reduce harm from potential nocturnal seizures...
July 11, 2018: Epilepsy & Behavior: E&B
Wen-Yu Lu, Wen-Chin Weng, Lee-Chin Wong, Wang-Tso Lee
BACKGROUND: Both refractory convulsive status epilepticus (SE) and super-refractory SE are medical emergencies. However, there are limited data on super-refractory SE in children. Thus, this study focuses on characterizing the demographics, outcomes, and prognostic factors for super-refractory SE in children. METHODS: This study was a retrospective analysis of super-refractory SE treated in a tertiary referral center in Taiwan. The functional outcome was evaluated by modified Rankin scale (mRS)...
July 10, 2018: Epilepsy & Behavior: E&B
Orrin Devinsky, Chloe Verducci, Elizabeth A Thiele, Linda C Laux, Anup D Patel, Francis Filloux, Jerzy P Szaflarski, Angus Wilfong, Gary D Clark, Yong D Park, Laurie E Seltzer, E Martina Bebin, Robert Flamini, Robert T Wechsler, Daniel Friedman
OBJECTIVE: We studied our collective open-label, compassionate use experience in using cannabidiol (CBD) to treat epilepsy in patients with CDKL5 deficiency disorder and Aicardi, Doose, and Dup15q syndromes. METHODS: We included patients aged 1-30 years with severe childhood-onset epilepsy who received CBD for ≥10 weeks as part of multiple investigator-initiated expanded access or state access programs for a compassionate prospective interventional study: CDKL5 deficiency disorder (n = 20), Aicardi syndrome (n = 19), Dup15q syndrome (n = 8), and Doose syndrome (n = 8)...
July 10, 2018: Epilepsy & Behavior: E&B
Gabriel Tremblay, Daniel Howard, Wan Tsong, Vardhaman Patel, Jesús De Rosendo
BACKGROUND: Persistent seizures are associated with physical injury, reduced quality of life, and psychosocial impairment. Perampanel is approved for the adjunctive treatment of primary generalized tonic-clonic seizures (PGTCS). OBJECTIVE: This study aimed to determine the cost-effectiveness of perampanel as adjunctive therapy to other antiepileptic drugs (AED) compared with AED maintenance therapy alone for the treatment of PGTCS. METHODS: We developed a Markov model for PGTCS where transitions were based on treatment response rates...
July 9, 2018: Epilepsy & Behavior: E&B
Temitayo Oyefunmike Oyegbile, John W VanMeter, Gholam Motamedi, Nassim Zecavati, Cesar Santos, Christabel Lee Earn Chun, William D Gaillard, Bruce Hermann
OBJECTIVES: Children with temporal lobe epilepsy (TLE) exhibit executive dysfunction on traditional neuropsychological tests. However, there is limited evidence of neural network alterations associated with this clinical executive dysfunction. The objective of this study was to characterize working memory deficits in children with TLE via activation of the executive control network on functional magnetic resonance imaging (fMRI) and determine the relationships to fMRI behavioral findings and traditional neuropsychological tests...
July 9, 2018: Epilepsy & Behavior: E&B
Lucretia Long, Sheri Cotterman-Hart, Jennae Shelby
OBJECTIVE: The study aimed to evaluate adult patient or caregiver feelings and viewpoints about sudden unexpected death in epilepsy (SUDEP) awareness. BACKGROUND: The decision to discuss SUDEP with patients and families has created much debate. Many healthcare providers (HCPs) are hesitant to discuss SUDEP because of the perception of evoking unnecessary fear in patients while others argue that informing patients about SUDEP may enhance patient compliance, improve seizure control, and aid in saving lives...
July 9, 2018: Epilepsy & Behavior: E&B
Kimford Meador
No abstract text is available yet for this article.
July 9, 2018: Epilepsy & Behavior: E&B
Blandine Dozières-Puyravel, Laurent François, Silvana de Lucia, Estelle Goujon, Marion Danse, Stéphane Auvin
Ketogenic diets (KDs) are well-established treatments for pharmacoresistant epilepsies and some metabolic disorders. The amount of publications including evidence-based trials has continuously increased in the last 10 years. We evaluated the use of KDs in France using 2 surveys from more than ten years ago (2005 and 2008). METHODS: We conducted a new survey based on 10 questions to evaluate the evolution of the practice since 2008 and the thoughts of French pediatric neurologists on the barriers as well as possible ways to support the use of KDs...
July 8, 2018: Epilepsy & Behavior: E&B
Rebecca O'Dwyer, Richard Byrne, Fiona Lynn, Pouya Nazari, Travis Stoub, Michael C Smith, Sepehr Sani
BACKGROUND: A quarter of patients with newly diagnosed epilepsy are older, yet they are less likely to be offered resective surgery potentially because of clinical bias that they incur increased surgical risks. There are few peer-reviewed case series that address this cohort and their outcomes. OBJECTIVE: In the context of current literature, the objective of this study was to report on all epilepsy surgeries in patients aged 50 years or older from a tertiary care center over 15 years with an average follow-up period of 6 years...
July 8, 2018: Epilepsy & Behavior: E&B
Sander R Hilberink, Marion van Ool, Heleen A van der Stege, Michelle C van Vliet, Heidi J M van Heijningen-Tousain, Anton J A de Louw, AnneLoes van Staa
INTRODUCTION: The consequences of having epilepsy seriously hamper the development of autonomy for youth with epilepsy (YWE) and limit their social participation. This study was designed to provide insight into the impact of epilepsy on autonomy and empowerment and to evaluate the use of the Skills for Growing Up (SGU-Epilepsy) communication tool in pediatric epileptic care. METHODS: A mixed methods design was used to examine the impact of epilepsy on autonomy and empowerment and to evaluate the feasibility and use of the SGU-Epilepsy...
July 8, 2018: Epilepsy & Behavior: E&B
Danmeng Wei, Matthew Garlinghouse, Wenyang Li, Nicholas Swingle, Kaeli K Samson, Olga Taraschenko
BACKGROUND: Psychogenic nonepileptic spells (PNES) are paroxysmal movements or sensory events that resemble epileptic seizures but lack corresponding ictal electrographic changes. A confirmed diagnosis of PNES is only accomplished via video electroencephalogram (vEEG) monitoring. Prior to diagnosis, patients are often assessed with neurodiagnostic imaging and their conditions treated with anticonvulsant medications, both of which are of limited clinical value and contribute to the higher cost of care...
July 4, 2018: Epilepsy & Behavior: E&B
Stacy Schantz Wilkins, Boulenouar Mesraoua, Gonzalo Alarcón Palomo, Hassan Al Hail, Abdul Salam, Gayane Melikyan, Nabil Azar, Naim Haddad, Bassim Uthman, Maria Siddiqi, Lubna Elsheikh, Musab Ali, Abdulraheem Alrabi, Ashfaq Shuaib, Dirk Deleu, Ali A Asadi-Pooya
OBJECTIVE: The Middle Eastern country of Qatar opened its first epilepsy monitoring unit (EMU) in late 2015. This study compared demographic and clinical characteristics of patients with confirmed epilepsy to those of patients with confirmed psychogenic nonepileptic seizures (PNES). METHODS: Data were collected via retrospective chart review on 113 patients admitted for evaluation to the Qatar national health system EMU between November 2015 and May 2017. RESULTS: Seventy-one patients had a confirmed diagnosis (20 had PNES, 46 had epilepsy, 5 had both PNES and epilepsy)...
July 3, 2018: Epilepsy & Behavior: E&B
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