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Epilepsy & Behavior: E&B

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https://www.readbyqxmd.com/read/27889242/benign-mesial-temporal-lobe-epilepsy-a-clinical-cohort-and-literature-review
#1
REVIEW
Amal AlQassmi, Jorge G Burneo, Richard S McLachlan, Seyed M Mirsattari
OBJECTIVE: We present a single-center retrospective study of benign mesial temporal lobe epilepsy (bMTLE) between 1995 and 2014. METHODS: Hospital records and clinic charts were reviewed. The clinical, Eelectroencephalographic (EEG), imaging features, and response to treatment with antiepileptic drugs (AEDs) were documented. Patients were included in this study if they were seizure-free for a minimum of 24months with or without an AED. RESULTS: Twenty-seven patients were identified...
November 23, 2016: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/27884642/psychiatric-comorbidities-in-epilepsy-should-they-be-considered-in-the-classification-of-epileptic-disorders
#2
Andres M Kanner
The prevalence of psychiatric comorbidities is relatively high in people with epilepsy (PWE), as one in three patients will have experienced a psychiatric disorder in the course of their life. The new definition of epilepsy recognizes these comorbidities as part of the seizure disorder, which need to be recognized and treated together with the actual epileptic seizures. Psychiatric comorbidities have a complex relation with epilepsy, being associated with a negative course of the seizure disorder, worse tolerance of pharmacotherapy with AEDs, development of iatrogenic psychiatric complications from pharmacologic and surgical treatments, and increased mortality risks...
November 21, 2016: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/27875784/anticonvulsant-effect-of-dextrometrophan-on-pentylenetetrazole-induced-seizures-in-mice-involvement-of-nitric-oxide-and-n-methyl-d-aspartate-receptors
#3
Gholamreza Mohseni, Sattar Ostadhadi, Reyhaneh Akbarian, Mohsen Chamanara, Abbas Norouzi-Javidan, Ahmad-Reza Dehpour
Dextrometrophan (DM), widely used as an antitussive, has recently generated interest as an anticonvulsant drug. Some effects of dextrometrophan are associated with alterations in several pathways, such as inhibition of nitric oxide synthase (NOS) enzyme and N-methyl d-aspartate (NMDA) receptors. In this study, we aimed to investigate the anticonvulsant effect of acute administration of dextrometrophan on pentylenetetrazole (PTZ)-induced seizures and the probable involvement of the nitric oxide (NO) pathway and NMDA receptors in this effect...
November 19, 2016: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/27876294/reprint-of-the-new-approach-to-epilepsy-classification-cognition-and-behavior-in-adult-epilepsy-syndromes
#4
REVIEW
Sallie Baxendale, Pamela Thompson
The revised terminology and concepts for the organization of seizures and epilepsy proposed by the ILAE Commission on Classification and Terminology in 2010 allows for a number of new opportunities in the study of cognition and behavior in adults. This review examines the literature that has looked for behavioral and cognitive correlates of the newly recognized genetic epilepsies in adults. While some studies report clear cognitive phenotypes associated with specific genetic mutations in adults with epilepsy, others report remarkable clinical heterogeneity...
November 18, 2016: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/27876293/foreword
#5
EDITORIAL
Sallie Baxendale, Sarah Wilson
No abstract text is available yet for this article.
November 18, 2016: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/27876292/reprint-of-the-new-approach-to-classification-rethinking-cognition-and-behavior-in-epilepsy
#6
REVIEW
Sarah J Wilson, Sallie Baxendale
There has been considerable debate surrounding the benefits and drawbacks of the new approach to classifying the epilepsies released by the ILAE Commission on Classification and Terminology (2005-2009). This new approach has significant implications for the way we conceptualize and assess cognition and behavior in epilepsy; however, as yet, there has been limited discussion of these issues in the field. The purpose of this Targeted Review is to spark this discussion by encouraging researchers and clinicians to think about the changes that the new approach may bring...
November 18, 2016: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/27866083/neuroanatomical-differences-in-fast-and-slow-rat-strains-with-differential-vulnerability-to-kindling-and-behavioral-comorbidities
#7
Pragati Sharma, Stefanie Dedeurwaerdere, Michael A D Vandenberg, Ke Fang, Leigh A Johnston, Sandy R Shultz, Terence J O'Brien, Krista L Gilby
OBJECTIVE: The neurobiological factors underlying a predisposition towards developing epilepsy and its common behavioral comorbidities are poorly understood. FAST rats are a strain that has been selectively bred for enhanced vulnerability to kindling, while the SLOW strain has been bred to be resistant to kindling. FAST rats also exhibit behavioral traits reminiscent of those observed in neurodevelopmental disorders (autism spectrum disorder (ASD)/attention-deficit/hyperactivity disorder (ADHD)) commonly comorbid with epilepsy...
November 17, 2016: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/27865173/accelerated-cognitive-decline-in-a-rodent-model-for-temporal-lobe-epilepsy
#8
Sandra Schipper, Marlien W Aalbers, Kim Rijkers, Melanie Lagiere, Jan G Bogaarts, Arjan Blokland, Sylvia Klinkenberg, Govert Hoogland, Johan S H Vles
OBJECTIVE: Cognitive impairment is frequently observed in patients with temporal lobe epilepsy. It is hypothesized that cumulative seizure exposure causes accelerated cognitive decline in patients with epilepsy. We investigated the influence of seizure frequency on cognitive decline in a rodent model for temporal lobe epilepsy. METHODS: Neurobehavioral assessment was performed before and after surgery, after the induction of self-sustaining limbic status epilepticus (SSLSE), and in the chronic phase in which rats experienced recurrent seizures...
November 16, 2016: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/27863278/neoplasm-study-real-life-use-of-lacosamide-in-patients-with-brain-tumor-related-epilepsy
#9
Vicente Villanueva, Rosana Saiz-Diaz, Manuel Toledo, Ana Piera, Jose Angel Mauri, Juan Jesús Rodriguez-Uranga, Francisco Javier López-González, Asier Gómez-Ibáñez, Mercedes Garcés, Jesús González de la Aleja, Xiana Rodríguez-Osorio, Susana Palao-Duarte, Ascensión Castillo, Macarena Bonet, Jesús Ruiz-Giménez, Juan Palau, Alberto Arcediano, Maria Toledo, Ana Gago
BACKGROUND: The choice of antiepileptic drug (AED) therapy in patients with brain tumor-related epilepsy (BTRE) is complicated, and there are a lack of robust clinical trial data to date. METHODS: The NEOPLASM (Neuroncologic Patients treated with LAcoSaMide) study was a 6-month, multicenter, retrospective, observational study in patients with BTRE treated with lacosamide. Patients were started on lacosamide because of a lack of efficacy or adverse events (AEs) with prior AEDs or suitability versus other AEDs, according to clinical practice...
November 15, 2016: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/27855355/seizure-control-and-cognitive-improvement-via-immunotherapy-in-late-onset-epilepsy-patients-with-paraneoplastic-versus-gad65-autoantibody-associated-limbic-encephalitis
#10
N Hansen, G Widman, J-A Witt, J Wagner, A J Becker, C E Elger, C Helmstaedter
OBJECTIVE: To determine the efficacy of immunotherapy in limbic encephalitis (LE) associated epilepsies with autoantibodies against intracellular antigens in the forms of paraneoplastic autoantibodies versus glutamic acid decarboxylase 65 (GAD)-autoantibodies. METHODS: Eleven paraneoplastic-antibodies+ and eleven age- and gender-matched GAD-antibodies+ patients with LE were compared regarding EEG, seizure frequency, MRI volumetry of the brain, and cognition. All patients received immunotherapy with corticosteroids add-on to antiepileptic therapy...
November 14, 2016: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/27842976/go-with-the-flow
#11
EDITORIAL
Jerome Engel
No abstract text is available yet for this article.
November 11, 2016: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/27838562/quality-of-life-in-epilepsy-31-inventory-qolie-31-scores-a-global-comparison
#12
REVIEW
Altaf Saadi, Bryan Patenaude, Farrah J Mateen
Quality of life is a pragmatic endpoint for understanding the experience of people with epilepsy (PWE) in low- and middle-income countries (LMICs), where>80% of PWE reside. However, the literature is bereft of QOL in epilepsy (QOLIE) studies among LMICs and knowledge of the variation in QOLIE globally. We therefore performed a Medline search of original research studies using the quality of life in epilepsy-31 inventory (QOLIE-31) in a recent fifteen-year period (2000-2015). Each of the 194 countries listed by the World Health Organization (WHO) was individually included as search terms...
November 10, 2016: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/27829187/behavioral-health-in-young-adults-with-epilepsy-implications-for-transition-of-care
#13
Janelle L Wagner, Dulaney A Wilson, Tanja Kellermann, Gigi Smith, Angela M Malek, Braxton Wannamaker, Anbesaw W Selassie
AIM: Neurodevelopmental and behavioral health disorders commonly occur with epilepsy, yet risk for young adults is unknown. The aim of this study was to determine the distribution and risk characteristics of neurodevelopmental and behavior health comorbidities among young adults with epilepsy compared with those among young adults with migraine and healthy controls. METHOD: A case-control study examining hospital admission, outpatient, and emergency department (ED) visits for young adults with an ICD-9-CM diagnosis of epilepsy, migraine, or lower extremity fracture (LEF) was conducted...
November 6, 2016: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/27825562/a-step-at-a-time
#14
EDITORIAL
Liz Molyneux
No abstract text is available yet for this article.
November 4, 2016: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/27806905/a-bridge-between-neurology-and-psychiatry
#15
EDITORIAL
Edward H Reynolds
No abstract text is available yet for this article.
October 30, 2016: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/27829186/counseling-by-epileptologists-affects-contraceptive-choices-of-women-with-epilepsy
#16
Alyssa R Espinera, Jay Gavvala, Irena Bellinski, Jeffrey Kennedy, Micheal P Macken, Aditi Narechania, Jessica Templer, Stephen VanHaerents, Stephan U Schuele, Elizabeth E Gerard
INTRODUCTION: There are several important interactions between antiepileptic drugs (AEDs) and hormonal contraception that need to be carefully considered by women with epilepsy (WWE) and their practitioners. Many AEDs induce hepatic enzymes and decrease the efficacy of hormonal contraception. In addition, estrogen-containing hormonal contraception can increase the metabolism of lamotrigine, the most commonly prescribed AED in women of childbearing age. The intrauterine device (IUD) is a highly effective form of reversible contraception without AED drug interactions that is considered by many to be the contraceptive of choice for WWE...
October 29, 2016: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/27780086/are-people-with-epilepsy-using-ehealth-tools
#17
Loes A M Leenen, Ben F M Wijnen, Reina J A de Kinderen, Caroline M van Heugten, Silvia M A A Evers, Marian H J M Majoie
INTRODUCTION: Self-management for people with epilepsy (PWE) should lead to shared decision-making and thus to adherence to the treatment plan. eHealth is an important way of supporting PWE in their self-management. METHOD: In this survey, we used a mixed method to explore the following: 1) which factors were monitored by PWE and how (using pen and paper or eHealth-tools), 2) how many PWE own a computer or smartphone, and 3) how do they perceive the use of eHealth...
October 22, 2016: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/27780085/proceedings-of-the-eighth-international-workshop-on-advances-in-electrocorticography
#18
Anthony L Ritaccio, Justin Williams, Tim Denison, Brett L Foster, Philip A Starr, Aysegul Gunduz, Maeike Zijlmans, Gerwin Schalk
Excerpted proceedings of the Eighth International Workshop on Advances in Electrocorticography (ECoG), which convened October 15-16, 2015 in Chicago, IL, are presented. The workshop series has become the foremost gathering to present current basic and clinical research in subdural brain signal recording and analysis.
October 22, 2016: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/27776299/effects-of-different-physical-exercise-programs-on-susceptibility-to-pilocarpine-induced-seizures-in-female-rats
#19
Diego Vannucci Campos, Glauber Menezes Lopim, Vanessa Santos de Almeida, Débora Amado, Ricardo Mario Arida
No abstract text is available yet for this article.
October 21, 2016: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/27776298/neurologists-can-identify-diagnostic-linguistic-features-during-routine-seizure-clinic-interactions-results-of-a-one-day-teaching-intervention
#20
Laura Jenkins, Jeremy Cosgrove, Paul Chappell, Ammar Kheder, Dilraj Sokhi, Markus Reuber
The diagnostic distinction between epilepsy and psychogenic nonepileptic seizures (PNES) can be challenging. Previous studies have demonstrated that experts in conversation analysis can identify linguistic and interactional features in transcripts and recordings of interviews with patients that reliably distinguish between epilepsy and PNES. In this study, ten senior neurology trainees took part in a one-day intervention workshop about linguistic and interactional differences in the conversation behavior of patients with epilepsy and those with PNES...
October 21, 2016: Epilepsy & Behavior: E&B
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