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Epilepsy & Behavior: E&B

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https://www.readbyqxmd.com/read/29778846/efficacy-and-tolerability-of-treatment-with-lacosamide-postmarketing-experience-from-the-middle-east-region
#1
Maher Arabi, Taoufik Alsaadi, Wassim Nasreddine, Jasem Al-Hashel, Maya Dirani, Ahmad Beydoun
PURPOSE: Lacosamide (LCM) was recently introduced in the Middle East. The aim of this study was to evaluate the safety, tolerability, and efficacy of LCM in patients with focal onset seizures and determine if our results are comparable with those derived from Western countries. METHODS: This is a retrospective analysis from two medical centers on consecutive patients diagnosed as having focal onset seizures and treated with add-on LCM. The primary efficacy variables were the 50% responder and seizure-free rates, and the secondary outcome variables included the percentages of patients who achieved seizure remission during the last 6-month follow-up period and the percentages of discontinuation due to lack of efficacy or tolerability...
May 17, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29778845/predictors-of-long-term-mortality-in-status-epilepticus
#2
Somsak Tiamkao, Pawinee Saybungkla, Prapassara Sirikarn, Kittisak Sawanyawisuth
BACKGROUND: There were several studies that have reported on the long-term mortality rate of status epilepticus (SE). However, these studies were conducted mainly in Western countries using small study populations. This study aimed to evaluate predictors for long-term mortality in SE using the Thai national healthcare database. METHODS: This study was conducted using the Thai national Universal Health Coverage (UC) database. The eligibility criteria for this study were that all patients were diagnosed with SE and had been admitted to any hospital between 2005 and 2015...
May 17, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29775848/long-term-outcome-in-children-with-neonatal-seizures-a-tertiary-center-experience-in-cohort-of-168-patients
#3
Biljana Vucetic Tadic, Ruzica Kravljanac, Vlada Sretenovic, Vladislav Vukomanovic
PURPOSE: The purpose of this study was to evaluate long-term outcome and assess predictors of prognosis in children with neonatal seizures (NS). METHOD: This retrospective study includes children with NS treated at our Institute from January the 1st 2005 until December the 31st 2015. The data were collected from medical charts and the electroencephalogram (EEG) database at the Institute. The predictive value was evaluated for following parameters: (1) characteristics of the patients, such as gender, gestational age, birth body weight, Apgar score, artificial ventilation; (2) etiology; (3) characteristics of seizures such as type, time of onset, resistance to treatment; and (4) EEG background activity and paroxysmal discharges...
May 15, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29764729/epilepsy-south-africa-celebrates-its-50th-anniversary
#4
EDITORIAL
Marina Clarke
No abstract text is available yet for this article.
May 12, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29758446/improving-staff-response-to-seizures-on-the-epilepsy-monitoring-unit-with-online-eeg-seizure-detection-algorithms
#5
Nicole Rommens, Evelien Geertsema, Lisanne Jansen Holleboom, Fieke Cox, Gerhard Visser
OBJECTIVE: User safety and the quality of diagnostics on the epilepsy monitoring unit (EMU) depend on reaction to seizures. Online seizure detection might improve this. While good sensitivity and specificity is reported, the added value above staff response is unclear. We ascertained the added value of two electroencephalograph (EEG) seizure detection algorithms in terms of additional detected seizures or faster detection time. METHODS: EEG-video seizure recordings of people admitted to an EMU over one year were included, with a maximum of two seizures per subject...
May 11, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29758445/intravenous-lacosamide-lcm-in-status-epilepticus-se-weight-adjusted-dose-and-efficacy
#6
Estevo Santamarina, Montserrat González-Cuevas, Manuel Toledo, Marta Jiménez, Juan Luis Becerra, Alex Quílez, Ana Suller, J A Mauri, Ángel Fernández, Ainhoa Marinas, Manuel Quintana, Xavier Salas Puig
BACKGROUND: Some studies suggest higher efficacy of lacosamide (LCM) in status epilepticus (SE) with higher loading doses; however, this weight-adjusted dose has not been evaluated. OBJECTIVE: The objective was to evaluate the relationship between loading weight-adjusted dose and efficacy of LCM in SE. METHODS: A group of patients with SE treated with LCM from Spanish hospitals was examined retrospectively. Demographic data, type of SE, etiology, response rate, last antiepileptic drug (AED) used, treatment line in which LCM was used, total loading dose, and weight-adjusted dose were collected...
May 11, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29758444/yield-of-eeg-monitoring-in-children-with-developmental-disabilities-is-high
#7
Ali A Asadi-Pooya
PURPOSE: The purpose of this study was to investigate the yield of a 2-hour electroencephalography (EEG) monitoring (awake and sleep) in children with developmental disabilities and without any clinically apparent seizures. METHODS: In this retrospective study, I investigated all children below 9 years of age who had developmental disabilities and were referred to Shiraz Comprehensive Epilepsy center for electroencephalographic investigation from June 2017 until January 2018...
May 11, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29754110/ghanaian-traditional-and-faith-healers-explanatory-models-for-epilepsy
#8
Lily Kpobi, Leslie Swartz, Mpoe Johannah Keikelame
Epilepsy is the most common neurological condition in sub-Saharan Africa. A significant number of people with epilepsy in low- and middle-income countries do not receive formal biomedical care. They utilize the services of various traditional and alternative medicine practitioners. However, there is relatively little information about the beliefs and methods of alternative healthcare providers about epilepsy in many African countries. Using explanatory models of illness framework, we interviewed thirty-six traditional and faith healers in Ghana on their beliefs and perceptions about epilepsy, as well as how they would treat epilepsy...
May 10, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29754109/improving-effect-of-mild-foot-electrical-stimulation-on-pentylenetetrazole-induced-impairment-of-learning-and-memory
#9
Monir Abasi-Moghadam, Arefe Ghasemi-Dehno, Mehdi Sadegh, Mohammad Reza Palizvan
Epilepsy is a common neurological disorder that affects learning and memory. Recently it has been shown that mild foot electrical stimulation (MFES) can increase learning and memory in normal rats. Pentylenetetrazole (PTZ) kindling is a model of human epilepsy. As with human epilepsy, PTZ kindling impairs learning and memory in rats. The purpose of this study was to investigate the effect MFES on kindling-induced learning and memory deficits in rats. Forty-nine male Wistar rats weighting 200 to 250 g were divided into the following seven groups: PTZ only, phenytoin only, MFES only, PTZ plus phenytoin, PTZ plus MFES, phenytoin plus MFES, and saline (control), with the treatments administered for 26 days...
May 10, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29754108/knowledge-of-women-issues-and-epilepsy-among-doctors-in-sudan
#10
Awab K Elnaeim, Mohamed K Elnaeim, Ismat B A Babiker
OBJECTIVE: The objective of this study was to assess the knowledge of doctors in Sudan about women issues related to epilepsy. METHODS: In this cross-sectional study that was conducted in Sudan during the period from October 2017 to December 2017, we used Google forms to collect data from 154 doctors using Knowledge of Women Issues and Epilepsy (KOWIE) II standardized questionnaire. RESULTS: Our studied group included house officers (n = 34), medical officers (n = 60), registrars (n = 52), and specialists (n = 8)...
May 10, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29754107/amantadine-a-new-treatment-for-refractory-electrical-status-epilepticus-in-sleep
#11
Rujuta B Wilson, Yazan Eliyan, Raman Sankar, Shaun A Hussain
PURPOSE: Electrical status epilepticus in sleep (ESES) is an electrographic abnormality linked to language abnormalities and cognitive dysfunction and specifically associated with Landau-Kleffner syndrome (LKS), the syndrome of continuous spike and wave in slow-wave sleep (CSWS), and autistic regression with epileptiform EEG (AREE). As first-line therapies for treatment of ESES display inadequate efficacy and confer substantial risk, we set out to describe our center's experience with amantadine in the treatment of ESES...
May 10, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29753296/mortality-specific-comorbidity-among-inpatients-with-epilepsy-a-preliminary-cross-sectional-study-in-west-china
#12
Yang Si, Xiaoqiang Xiao, Hongbin Sun
PURPOSE: The purpose of this study was to investigate the current condition of mortality-specific comorbidity among hospitalized patients with epilepsy (PWE). METHODS: The discharge abstract records of PWE from over 730,000 admissions were extracted from the hospital medical database. Fourteen mortality-related comorbidities from an epilepsy-specific index (ESI) were selected for the present assessment. The hospital-based prevalence of these comorbidities was estimated...
May 9, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29753295/major-depressive-disorder-in-epilepsy-clinics-a-meta-analysis
#13
REVIEW
Minjung Kim, Young-Soo Kim, Do-Hyung Kim, Tae-Won Yang, Oh-Young Kwon
BACKGROUND AND PURPOSE: Although depression is a frequent psychiatric comorbidity in people with epilepsy (PWE), its prevalence has been underestimated. Comorbid depression has negative impacts on treatment outcomes and quality of life (QOL). It also causes various problems in PWE, such as fatigue, irritability, and suicidality. This meta-analysis was performed to estimate the frequency of major depression disorder (MDD) in clinics managing PWE. METHODS: We searched MEDLINE, EMBASE, Cochrane Library, Web of Science, and SCOPUS to identify studies...
May 9, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29753294/prescription-trends-and-psychiatric-symptoms-following-first-receipt-of-one-of-seven-common-antiepileptic-drugs-in-general-practice
#14
Colin B Josephson, Jordan D T Engbers, Nathalie Jette, Scott B Patten, Tolulope T Sajobi, Deborah Marshall, Mark Lowerison, Samuel Wiebe
We sought to examine the risk of psychiatric symptoms associated with a first prescription for specific antiepileptic drugs (AEDs) used in monotherapy in a general cohort of patients with epilepsy. We used The Health Improvement Network database (comprising the years 2000-2012) to identify incident patients with epilepsy. The index date was that on which they met the case definition for epilepsy, and analyses only included patients who remained on monotherapy or received no AED therapy following diagnosis to avoid confounding by polytherapy...
May 9, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29753293/risk-assessment-of-in-hospital-mortality-of-patients-with-epilepsy-a-large-cohort-study
#15
Yang Si, Xiaoqiang Xiao, Shunju Xiang, Jing Liu, Qianning Mo, Hongbin Sun
PURPOSE: This study aimed to explore the mortality risks of hospitalized patients with epilepsy (PWE). METHODS: Our data source was extracted from discharge abstracts in a hospital medical database. Various clinical variables, including demographical characteristics, natural features of epilepsy, and comprehensive set of comorbidities, were screened to investigate the risk. Comorbidities were defined using a validated ICD-10-based classification. The distributions of comorbid conditions and demographics were presented...
May 9, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29752000/noncompliance-of-patients-with-driving-restrictions-due-to-uncontrolled-epilepsy
#16
Laurent M Willems, Philipp S Reif, Susanne Knake, Hajo M Hamer, Constantin Willems, Günter Krämer, Felix Rosenow, Adam Strzelczyk
Epilepsies are a common and chronic neurological disorder characterized by sustained risk of recurrent seizures. Because of paroxysmal and often unpredictable occurrence of seizures, patients with uncontrolled epilepsy are subject to disease-specific restrictions in daily life, such as their career choice or specific work limitations. According to German law and many other European and international guidelines, driving is strictly prohibited in patients with uncontrolled epilepsy so as to increase active and passive safety in public road traffic...
May 9, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29747033/optimizing-parents-performance-in-anticonvulsant-rescue-medication-administration
#17
Pia Madeleine Schumacher, Almuth Kaune, Andreas Merkenschlager, Matthias Karl Bernhard, Wieland Kiess, Martina Patrizia Neininger, Astrid Bertsche, Thilo Bertsche
OBJECTIVE: Parents of children with epilepsy are at risk of committing high-risk handling errors with a high potential to harm the patient when administering anticonvulsant rescue medication. We developed a training concept addressing identified high-risk handling errors and investigated its effects on parents' skills. STUDY DESIGN: In a controlled prospective intervention study, parents of children with epilepsy were asked to demonstrate their administration of rescue medication by using dummy dolls...
May 7, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29738958/predictive-values-and-specificity-of-electroencephalographic-findings-in-autoimmune-encephalitis-diagnosis
#18
Chusak Limotai, Chayaporn Denlertchaikul, Abhinbhen W Saraya, Suda Jirasakuldej
OBJECTIVE: Early diagnosis of autoimmune encephalitis (AE) to not delay treatment is challenging but needed in practice. Most previous evidences of electroencephalographic (EEG) findings in AE were derived from descriptive studies. Given paucity of evidence of specific EEG findings to help with early diagnosis of AE, this study aimed to ascertain specific EEG findings and assess their predictive values in diagnosis of AE. METHODS: We included all cases with AE in our institution from January 2013 to June 2017...
May 5, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29734104/late-onset-anti-n-methyl-d-aspartate-receptor-encephalitis-in-china
#19
Le Zhang, Xu Liu, Xin-Yue Jiang, Yun-Hui Wang, Jin-Mei Li, Dong Zhou
PURPOSE: This study aimed to summarize the clinical characteristics and outcome of late-onset anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis in China. METHOD: All cases of people with a definitive diagnosis of anti-NMDAR encephalitis in West China Hospital between June 2012 and April 2017 were retrospectively reviewed. The demographics, clinical characteristics, and outcome of those patients (age≥45years old) were summarized. Comparisons were conducted between older (≥45years old) and younger (18-44years old) adults...
May 4, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29730501/language-skills-in-children-with-benign-childhood-epilepsy-with-centrotemporal-spikes-a-systematic-review
#20
REVIEW
Joana Teixeira, Maria Emília Santos
Benign childhood epilepsy with centrotemporal spikes (BECTS) is the epileptic syndrome that most affects preschool and school-age children. Despite being usually considered a benign condition, several studies have shown that this epileptic syndrome is responsible for cognitive morbidities in children, namely at the level of attention and memory, as well as language. However, language disorders are still superficially addressed by the literature. This review aimed to compile and synthesize recent literature in this area...
May 3, 2018: Epilepsy & Behavior: E&B
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