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Epilepsy & Behavior: E&B

Loretta Giuliano, Calogero Edoardo Cicero, Sandra Padilla, David Rojo Mayaregua, Walter Mario Camargo Villarreal, Vito Sofia, Mario Zappia, Alessandro Bartoloni, Elizabeth Blanca Crespo Gómez, Alessandra Nicoletti
INTRODUCTION: Epilepsy represents around 0.7% of the overall global burden of diseases and is particularly prevalent and associated with significant disability in low- and middle-income countries (LMIC) in Latin American Countries (LAC). A community-based epilepsy awareness program was carried out by our group in the rural areas of the Chaco region, Plurinational state of Bolivia, to improve the knowledge about epilepsy, with a first part directed toward general practitioners and a second part toward nurses and community health workers (CHWs) of the rural communities with a positive outcome...
January 8, 2019: Epilepsy & Behavior: E&B
Frances Rapport, Patti Shih, Mona Faris, Armin Nikpour, Geoffrey Herkes, Andrew Bleasel, Mike Kerr, Robyn Clay-Williams, Virginia Mumford, Jeffrey Braithwaite
This paper offers a new way of understanding the course of a chronic, neurological condition through a comprehensive model of patient-reported determinants of health and wellbeing: The Patient Reported ImpleMentation sciEnce (PRIME) model is the first model of its kind to be based on patient-driven insights for the design and implementation of initiatives that could improve tertiary, primary, and community healthcare services for patients with refractory epilepsy, and has broad implications for other disorders; PRIME focuses on: patient-reported determinants of health and wellbeing, pathways through care, gaps in treatment and other system delays, patient need and expectation, and barriers and facilitators to high-quality care provision; PRIME highlights that in the context of refractory epilepsy, patients value appropriate, clear, and speedy referrals from primary care practitioners and community neurologists to specialist healthcare professionals based in tertiary epilepsy centers...
January 8, 2019: Epilepsy & Behavior: E&B
Rima Nabbout, Alexis Arzimanoglou, Richard F M Chin, Zachary Grinspan, Kathy Speechley, Peter Camfield
There is limited information about the effectiveness of transition programs for youth moving from pediatric to adult care with any chronic disease. Two Delphi studies and National Institute for Health and Care Excellence (NICE) guidelines about transition for epilepsy have suggested few critical outcome measures for transition. A single large prospective study found that the most important transition program elements were appropriate parent involvement, promotion of health self-efficacy, and meeting the adult team before transfer...
January 6, 2019: Epilepsy & Behavior: E&B
Elena M Suleymanova, Maria A Borisova, Lyudmila V Vinogradova
Mood and anxiety disorders, as well as memory impairments, are important factors affecting quality of life in patients with epilepsy and can influence the antiepileptic therapy. Clinical studies of psychiatric comorbidities are quite complicated to design and interpret, so animal studies of behavioral impairments associated with seizures can be of use. We investigated the effect of early administration of endocannabinoid receptor agonist WIN-55,212-2 on the development of spontaneous seizures, long-term behavioral and memory impairments, and neurodegeneration in the hippocampus on the lithium-pilocarpine model of status epilepticus (SE)...
January 5, 2019: Epilepsy & Behavior: E&B
Do-Hyung Kim, Young-Soo Kim, Tae-Won Yang, Oh-Young Kwon
BACKGROUND AND PURPOSE: The Neurological Disorders Depression Inventory for Epilepsy (NDDI-E) is a useful inventory for screening major depressive disorder (MDD) in people with epilepsy (PWE). The cutoff score for detecting MDD has been reported with the range of >11 to >16. The aim of this study was to find optimal cutoff score of the NDDI-E for MDD detection by combining the raw data from previous studies. METHODS: We searched MEDLINE, EMBASE, Cochrane Library, Web of Science, and SCOPUS to identify proper studies...
January 4, 2019: Epilepsy & Behavior: E&B
Sara K Trowbridge, Christopher J Yuskaitis, Nicole Baumer, Mark Libenson, Sanjay P Prabhu, Chellamani Harini
INTRODUCTION: Infantile spasms (IS) are the most frequent epilepsy syndrome in children with Down syndrome (DS). In DS, cellular (synaptic/dendritic changes) and molecular mechanisms are believed to contribute to epileptogenesis, rather than gross structural anomalies. Neuroimaging is a standard part of the evaluation of newly diagnosed infantile epilepsy including IS and, in this age group, often requires sedation. It is unclear if neuroimaging provides additional clinically useful etiologic information in IS associated with DS...
January 4, 2019: Epilepsy & Behavior: E&B
Sunjay Nunley, Peter Glynn, Steve Rust, Jorge Vidaurre, Dara V F Albert, Anup D Patel
RATIONALE: About 20 per 100,000 children have convulsive status epilepticus every year, a life-threatening condition. Benzodiazepines are the first-line treatment for prolonged and recurrent seizures. Our study was designed to gain understanding of caregiver perception of acute seizure treatments. METHODS: Our project uses a cross-sectional survey study design using the electronic medical record and a survey at a large academic tertiary children's medical center...
January 3, 2019: Epilepsy & Behavior: E&B
Maja Milovanovic, Vlada Radivojevic, Jelena Radosavljev-Kircanski, Roberto Grujicic, Oliver Toskovic, Olivera Aleksić-Hil, Milica Pejovic-Milovancevic
PURPOSE: The purpose of this study was to determine the prevalence of epilepsy and subclinical epileptiform abnormalities in children with autism spectrum disorder (ASD), and to investigate its effects on core autistic symptoms and adaptive behavior skills. METHODS: Patients with diagnosis of ASD who met full criteria on Autism Diagnostic Interview-Revised (ADI-R) were included in the study. Adaptive behavior skills were assessed by Vineland Adaptive Behavior Scale-II (VABS-II)...
January 2, 2019: Epilepsy & Behavior: E&B
Christina Möller, Roelof Maarten van Dijk, Fabio Wolf, Michael Keck, Katharina Schönhoff, Vera Bierling, Heidrun Potschka
Although an impact of epilepsy on circadian rhythmicity is well-recognized, there are profound gaps in our understanding of the influence of seizures on diurnal rhythms. The effect on activity levels and heart rate is of particular interest as it might contribute to the disease burden. The kindling model with telemetric transmitter implants provides excellent opportunities to study the consequences of focal and generalized seizures under standardized conditions. Data from kindled rats with generalized seizures revealed an increase in activity and heart rate during the resting phase...
January 2, 2019: Epilepsy & Behavior: E&B
Joyce A Cramer, Krithika Rajagopalan, Kathryn Plante Anastassopoulos, David Blum
PURPOSE: While antiepileptic drug (AED) treatment effectiveness is traditionally assessed based on seizure frequency reduction (SFR), the overall value of AEDs in managing epilepsy and associated sequelae may be best assessed by how patients feel and function in terms of overall health-related quality of life (HRQoL). We conducted a pooled analysis of the Quality of Life in Epilepsy-31 (QOLIE-31) questionnaire from two phase 3 trials to explore the effect of response to conversion to eslicarbazepine acetate (ESL) monotherapy on HRQoL...
January 2, 2019: Epilepsy & Behavior: E&B
Adriana Bermeo-Ovalle
Psychiatric comorbidities are common in patients with epilepsy (PWE). Depression and anxiety are the most prevalent of these comorbidities and are associated with worse quality of life. Several screening tools are available to identify and follow up these conditions. However, time constrains in outpatient clinic visits and limited access to mental healthcare professionals discourage clinicians to use them. This paper discusses the advantage and limitations of screening tools and makes a compelling argument for neurologists to take an active role in the diagnosis and treatment of common psychiatric comorbidities in PWE...
December 29, 2018: Epilepsy & Behavior: E&B
Louis Jacob, Bettina Schmitz, Jens Bohlken, Karel Kostev
OBJECTIVE: The goal of this study was to analyze trends in valproate use in patients followed by neurologists and general practitioners in Germany between 2009 and 2017. METHODS: This study included all patients aged ≥15 years followed in 2009, 2013, and 2017 in neurological (N = 99) and general (N = 499) practices in Germany. Trends in valproate use were estimated based on the mean number of patients per practice who were prescribed valproate and the proportion of physicians prescribing it...
December 29, 2018: Epilepsy & Behavior: E&B
Jason Randhawa, Chantelle T Hrazdil, Islam Hassan
Seizures are commonly thought to occur in a spontaneous, unpredictable manner. However, it is well-established that a subset of patients with epilepsy can experience reflex seizures that are consistently elicited by a specific stimulus. While various forms of reflex epilepsy have been documented in the literature, acute affective states have not been commonly described as a potential reflex seizure trigger. We performed a systematic literature review to determine if acute emotional states can trigger reflex seizures...
December 29, 2018: Epilepsy & Behavior: E&B
Daria Putignano, Antonio Clavenna, Rita Campi, Maria Paola Canevini, Aglaia Vignoli, Dina Battino, Ettore Beghi, Emilio Perucca, Angela Bortolotti, Ida Fortino, Luca Merlino, Maurizio Bonati
Healthcare administrative databases of Italy's Lombardy Region were analyzed with the aim to assess perinatal outcomes and healthcare resource utilization during the first year of life in infants exposed to antiepileptic drugs (AEDs) during pregnancy. Drug prescriptions dispensed in the 12 months before delivery to women, who delivered between 2005 and 2011, were analyzed. Neonates were classified as cases if exposed to AEDs, and each case was randomly matched to seven controls. No significant differences were observed in the risk of congenital malformations between 526 cases and 3682 controls except for valproic acid (odds ratio (OR): 2...
December 29, 2018: Epilepsy & Behavior: E&B
Lance Vincent Watkins, William Owen Pickrell, Michael Patrick Kerr
This paper will explore the nature of psychiatric co-morbidities in people with an intellectual disability (ID) who have epilepsy. The complexity of clinical presentations and associated co-morbidities require thorough assessment utilising both neurological and psychiatric skills. The neurologist plays a central role in the management of epilepsy in people with ID and therefore requires basic competencies in the assessment of neuropsychiatric co-morbidities. This is key to liaison with other specialist services to ensure individuals receive holistic person-centred care...
December 28, 2018: Epilepsy & Behavior: E&B
Zouari Salma, Haj Kacem Hanen, Sakka Salma, Hdiji Olfa, Farhat Nouha, Damak Mariem, Mhiri Chokri
PURPOSE: The frequent association between headache and epilepsy has been increasingly studied in recent years. Through this study, we attempted to study possible temporal associations between epileptic seizures and headaches. We also tried to describe clinical aspects of headache in our patients with epilepsy. PATIENTS AND METHODS: We included patients with epilepsy and patients without epilepsy who presented for a first neurologic episode suggestive of epileptic seizure or unusual headache...
December 21, 2018: Epilepsy & Behavior: E&B
Iris Jaitovich Groisman, Thierry Hurlimann, Béatrice Godard
PURPOSE: The use of Next Generation Sequencing technologies (NGS), such as Whole Genome Sequencing (WGS), is expected to improve the often complex and protracted course of treatment of patients with epilepsy by providing an earlier and more accurate diagnosis. As part of the "Personalized medicine in the treatment of epilepsy" project, which aimed to determine whether WGS could be used as a valuable "diagnostic tool" in pharmacoresistant epilepsies, we examined parents' expectations, hopes, and concerns upon receiving results related to their child's epilepsy, comorbidities, resistance to medication, and genetic information on unrelated conditions, and how these results could impact their and their child's life...
December 21, 2018: Epilepsy & Behavior: E&B
Thierry Matonda-Ma-Nzuzi, Samuel Mampunza Ma Miezi, Dominique Charlier-Mikolajczak, Diane Muanza Mvumbi, Fanny Malendakana, Glennie Eba Ntsambi, Junior Nsundi Mayemba, Davin Mbeya Mpaka, Magloire Nkosi Mpembi, Gilbert Mananga Lelo
BACKGROUND: Epilepsy mostly affects children in sub-Saharan Africa. However, little is known about the therapeutic itinerary of these children living with epilepsy (CWE). This study aimed to describe the therapeutic itinerary of CWE in Kinshasa and to analyze its relationships with clinical features, behavioral problems, and cognitive impairment. METHODS: This hospital-based study has included 104 CWE aged 6 to 17 years. The features of their therapeutic itinerary and their relationship with clinical features, behavioral problems, and cognitive impairment were vast majority of CWE (87%) has started their therapeutic itinerary by the Western medicine...
December 20, 2018: Epilepsy & Behavior: E&B
Prince Antwi, Ece Atac, Jun Hwan Ryu, Christopher Andrew Arencibia, Shiori Tomatsu, Neehan Saleem, Jia Wu, Michael J Crowley, Barbara Banz, Federico E Vaca, Heinz Krestel, Hal Blumenfeld
Generalized spike-wave discharges (SWDs) are the hallmark of generalized epilepsy on the electroencephalogram (EEG). In clinically obvious cases, generalized SWDs produce myoclonic, atonic/tonic, or absence seizures with brief episodes of staring and behavioral unresponsiveness. However, some generalized SWDs have no obvious behavioral effects. A serious challenge arises when patients with no clinical seizures request driving privileges and licensure, yet their EEG shows generalized SWD. Specialized behavioral testing has demonstrated prolonged reaction times or missed responses during SWD, which may present a driving hazard even when patients or family members do not notice any deficits...
December 20, 2018: Epilepsy & Behavior: E&B
Reinhard Schulz, Christian G Bien, Theodor W May
OBJECTIVE: The objective of this study was to investigate the incidence of sudden unexpected death in epilepsy (SUDEP) in a tertiary epilepsy center in the years 1981-2016 with an emphasis on patient supervision and nursing intervention in different departments. METHODS: We identified 14 SUDEP cases (probable, definite, definite plus). Patient-years (PY) and incidence were calculated for the periods of six years for the general epileptology wards (adults and children) and, in addition, for the epilepsy monitoring unit (EMU) since 1990...
December 20, 2018: Epilepsy & Behavior: E&B
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