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Epilepsy & Behavior: E&B

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https://www.readbyqxmd.com/read/29033118/physical-activity-stigma-and-quality-of-life-in-patients-with-epilepsy
#1
Gloria Maria Almeida Souza Tedrus, Guilherme Sabbag Sterca, Renato Buarque Pereira
Indication of physical activity (PA) for people with epilepsy (PWE) is debatable. This study investigated whether the International Physical Activity Questionnaire (IPAQ) score is related to the clinical aspects of epilepsy, QOLIE-31, and the Stigma Scale of Epilepsy (SSE) score of 67 PWE at a significance level of 5% (p<0.05). About one-third (32.8%) of the PWE were sedentary/irregularly active. Lower QOLIE-31 scores and higher SSE scores were found in PWE who did not practice PA for fear of seizures and in sedentary/irregularly active PWE...
October 12, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28958777/incidence-of-sudden-unexpected-death-in-epilepsy-in-community-based-cohort-in-china
#2
Yan Ge, Ding Ding, Qing Zhang, Bin Yang, Taiping Wang, Beixu Li, Jie Wang, Jianfeng Luo, Patrick Kwan, Wenzhi Wang, Zhen Hong, Josemir W Sander
OBJECTIVE: Sudden unexpected death in epilepsy (SUDEP) is associated with the high premature mortality observed among people with epilepsy. It is, however, considered a rare event in China, probably because of lack of awareness and limitation of studies in the country. We aimed to provide some initial estimation of the burden of SUDEP in China. METHODS: We established a large Chinese community-based cohort of people with epilepsy between January 2010 and December 2011...
September 25, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28954709/visual-field-defects-following-different-resective-procedures-for-mesiotemporal-lobe-epilepsy
#3
Barbara Schmeiser, Moritz Daniel, Evangelos Kogias, Daniel Böhringer, Karl Egger, Shan Yang, Niels Alexander Foit, Andreas Schulze-Bonhage, Bernhard Jochen Steinhoff, Josef Zentner, Wolf Alexander Lagrèze, Nikolai Johannes Gross
INTRODUCTION: One of the most common side effects of mesiotemporal lobe resection in patients with medically intractable epilepsy are visual field defects (VFD). While peripheral defects usually remain unnoticed by patients, extended VFD influence daily life activities and can, in particular, affect driving regulations. This study had been designed to evaluate frequency and extent of VFD following different surgical approaches to the mesiotemporal area with respect to the ability to drive...
September 24, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28931473/psychiatric-and-behavioral-side-effects-of-antiepileptic-drugs-in-adults-with-epilepsy
#4
Baibing Chen, Hyunmi Choi, Lawrence J Hirsch, Austen Katz, Alexander Legge, Richard Buchsbaum, Kamil Detyniecki
PURPOSE: Psychiatric and behavioral side effects (PBSEs) are common, undesirable effects associated with antiepileptic drug (AED) use. The objective of the study was to compare the PBSE profiles of older and newer AEDs in a large specialty practice-based sample of patients diagnosed with epilepsy. METHODS: As part of the Columbia and Yale AED Database Project, we reviewed patient records including demographics, medical history, AED use, and side effects for 4085 adult patients (age: 18 years) newly started on an AED regimen...
September 17, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28928072/orbitofrontal-epilepsy-case-series-and-review-of-literature
#5
Imane Samah Chibane, Olivier Boucher, François Dubeau, Thi Phuoc Yen Tran, Ismail Mohamed, Richard McLachlan, R Mark Sadler, Richard Desbiens, Lionel Carmant, Dang Khoa Nguyen
BACKGROUND: Orbitofrontal epilepsy (OFE) is less known and is poorly characterized in comparison with temporal lobe epilepsy, partly because it is rare and possibly because it is unrecognized and therefore underestimated. OBJECTIVE: This paper aimed to better characterize seizure semiology, presurgical findings, and surgical outcomes in patients with OFE. METHODS: We retrospectively reviewed all confidently established OFE cases from six Canadian epilepsy monitoring units between 1988 and 2014, and in the literature between 1972 and 2017...
September 16, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28927716/the-effects-of-lifestyle-modification-and-statin-therapy-on-the-circulatory-markers-for-vascular-risk-in-patients-with-epilepsy
#6
Dong Wook Kim, Hyun Kyung Kim, Eun-Kee Bae
Although long-term therapy with antiepileptic drugs can increase the risk of vascular diseases, there have been little attempts to reduce the increased vascular risk in patients with epilepsy. We conducted a prospective longitudinal study to assess the effects of lifestyle modification and 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor (statin) therapy on the increased circulatory markers for vascular risk in patients with epilepsy. We recruited patients with increased vascular risk such as a history of vascular events or hypercholesterolemia, and they decided whether to be treated with statin or just to modify their lifestyle...
September 15, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28927715/microstructural-white-matter-changes-and-their-relation-to-neuropsychological-deficits-in-patients-with-juvenile-myoclonic-epilepsy
#7
Susanne Knake, Christine Roth, Marcus Belke, Jens Sonntag, Tobias Kniess, Soeren Krach, Andreas Jansen, Jens Sommer, Frieder M Paulus, Barbara Carl, Felix Rosenow, Anke M Hermsen, Katja Menzler
OBJECTIVE: Juvenile myoclonic epilepsy (JME) is the most common idiopathic generalized epilepsy syndrome. Neuropsychological, electrophysiological, and neuroimaging studies have led to the hypothesis that JME is related to dysfunction of frontal brain regions and mainly frontal thalamocortical networks. METHODS: We investigated possible microstructural white matter abnormalities of 20 patients with JME as compared with 20 healthy control subjects using diffusion tensor imaging (DTI)...
September 15, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28927714/differentiating-pnes-from-epileptic-seizures-using-conversational-analysis
#8
Costanza Papagno, Lorenzo Montali, Katherine Turner, Alessandra Frigerio, Martina Sirtori, Elena Zambrelli, Valentina Chiesa, Maria Paola Canevini
We applied conversation analysis in an unselected continuous series of 70 patients to discriminate patients with psychogenic nonepileptic seizures (PNES) from patients with epilepsy. Two psychologists examined the patients' recorded reports. Patients were also submitted to an extensive neuropsychological battery in order to verify whether specific cognitive deficits or mental health problems are typical of patients with PNES and whether some cognitive deficits could prevent the correct diagnosis. The results showed a good percentage of correct diagnosis, with a sensitivity of 0...
September 15, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28927713/risk-factors-of-early-adverse-drug-reactions-with-phenytoin-a-prospective-inpatient-cohort
#9
Reinaldo Uribe-San-Martín, Ethel Ciampi, Wilhelm Uslar, Silvana Villagra, Jose Plaza, Jaime Godoy, Patricio Mellado
INTRODUCTION: Phenytoin (PHT) is an effective and inexpensive antiepileptic drug (AED). However, its use has been limited for fear of adverse drug reactions (ADRs) and is being replaced by newer AED, increasing the costs and causing major budget problems, particularly for developing countries. OBJECTIVE: The objective of this study was to determine ADR frequency, explore, and establish related risk factors. METHODS: Prospective data were collected from a cohort of inpatients using PHT for the first time...
September 15, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28927712/real-world-data-on-rufinamide-treatment-in-patients-with-lennox-gastaut-syndrome-results-from-a-european-noninterventional-registry-study
#10
Marina Nikanorova, Christian Brandt, Stéphane Auvin, Rob McMurray
INTRODUCTION: Rufinamide is approved for the adjunctive treatment of seizures associated with Lennox-Gastaut syndrome (LGS) in patients aged ≥4years. The objective of this study was to provide real-world, long-term data on patients with LGS initiating rufinamide as add-on therapy and patients with LGS receiving other antiepileptic drugs (AEDs). METHODS: A Phase IV, noninterventional, multicenter registry study was conducted in patients with LGS aged ≥4years requiring modification to any AED treatment, including initiation of add-on rufinamide therapy...
September 15, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28927711/efficacy-tolerability-and-retention-rates-of-zonisamide-in-older-adult-patients-with-focal-onset-epilepsy-experiences-from-two-tertiary-epilepsy-centers
#11
Ebru Apaydın Doğan, Emine Genç, Bülent Oğuz Genç, Çağla Erdoğan
OBJECTIVE: The objective of this study was to evaluate the efficacy, tolerability, and retention rates for zonisamide (ZNS) in older adult patients with focal-onset epilepsy. PATIENTS AND METHODS: Chart reviews of patients aged 60years and older with focal-onset epilepsy treated with ZNS in two tertiary epilepsy centers were analyzed retrospectively. RESULTS: Eighty-five patients (41 males, 44 females) aged over 60years (range: 60-81) with focal-onset epilepsy treated with ZNS were identified; 55...
September 15, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28927710/the-hanging-of-derek-bentley-a-19-year-old-boy-with-epilepsy
#12
Mia Tuft, Karl O Nakken
Derek Bentley (1933-1953) was sentenced to death by hanging at the age of 19. He was convicted as a party to murder, and he died in Wandsworth Prison in London. After the police had reached the crime scene, he ostensibly shouted to his 16-year-old friend Christopher (Chris) Craig the ambiguous phrase, "Let him have it, Chris!" Chris fired shots at two policemen, wounding one and killing another. Derek Bentley had epilepsy and a mental age of about 11, and he could neither read nor write. In 1993, 40years after his death, he received a posthumous pardon from the British government...
September 15, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28927709/high-spirituality-may-be-associated-with-right-hemispheric-lateralization-in-korean-adults-living-with-epilepsy
#13
Sang-Ahm Lee, Myung-Ah Ko, Eun-Ju Choi, Ji-Ye Jeon, Han Uk Ryu
PURPOSE: Although it is known that epilepsy and spirituality are related, spirituality in epilepsy has received relatively little clinical and scientific attention. Therefore, we investigated which epilepsy-related factors are associated with high spirituality in Korean adults living with epilepsy. METHODS: This cross-sectional study was conducted in two university hospitals in Korea. Spirituality was assessed using the 6-item Spirituality Self-Rating Scale (SSRS)...
September 15, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28919388/altered-brain-functional-connectivity-induced-by-physical-exercise-may-improve-neuropsychological-functions-in-patients-with-benign-epilepsy
#14
Gyan Raj Koirala, Dongpyo Lee, Soyong Eom, Nam-Young Kim, Heung Dong Kim
OBJECTIVE: The objective of this study was to elucidate alteration in functional connectivity (FC) in patients with benign epilepsy with centrotemporal spikes (BECTS) as induced by physical exercise therapy and their correlation to the neuropsychological (NP) functions. METHODS: We analyzed 115 artifact- and spike-free 2-second epochs extracted from resting state EEG recordings before and after 5weeks of physical exercise in eight patients with BECTS. The exact Low Resolution Electromagnetic Tomography (eLORETA) was used for source reconstruction...
September 15, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28919387/health-related-quality-of-life-in-adolescents-with-epilepsy-in-montenegro
#15
Nelica Ivanović Radović, Ksenija Božić, Aleksandra Plećaš Đurić, Sanja Vodopić, Ljiljana Radulović, Slavica Vujisić
OBJECTIVE: The objective of this study was to establish potential risk factors for poor health-related quality of life among adolescents with epilepsy in Montenegro. MATERIAL AND METHODS: A sample of 104 adolescents with epilepsy (age: 11-19years) at a tertiary referral center in Podgorica, Montenegro, completed the validated Serbian version of the QOLIE-AD-48 questionnaire. They were divided into two groups: a group with active epilepsy (60 adolescents) and a group with inactive epilepsy (44 adolescents)...
September 14, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28919386/comparison-of-lacosamide-versus-sodium-valproate-in-status-epilepticus-a-pilot-study
#16
Usha K Misra, Deepanshu Dubey, Jayantee Kalita
PURPOSE: The purpose of this study was to compare the efficacy and safety of lacosamide (LCM) and sodium valproate (SVA) in lorazepam (LOR)-resistant SE. METHODS: Patients with LOR-resistant SE were randomized to intravenous LCM 400mg at the rate of 60mg/kg/min or SVA 30mg/kg at the rate of 100mg/min. The SE severity score (STESS), duration of SE and its etiology, and MRI findings were noted. Primary outcome was seizure cessation for 1h, and secondary outcomes were 24h seizure remission, in-hospital death, and severe adverse events (SAE)...
September 14, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28917501/personalized-translational-epilepsy-research-novel-approaches-and-future-perspectives-part-i-clinical-and-network-analysis-approaches
#17
REVIEW
Felix Rosenow, Natascha van Alphen, Albert Becker, Andreas Chiocchetti, Ralf Deichmann, Thomas Deller, Thomas Freiman, Christine M Freitag, Johannes Gehrig, Anke M Hermsen, Peter Jedlicka, Christian Kell, Karl Martin Klein, Susanne Knake, Dimitri M Kullmann, Stefan Liebner, Braxton A Norwood, Diana Omigie, Karlheinz Plate, Andreas Reif, Philipp S Reif, Yvonne Reiss, Jochen Roeper, Michael W Ronellenfitsch, Stephanie Schorge, Gerhard Schratt, Stephan W Schwarzacher, Joachim P Steinbach, Adam Strzelczyk, Jochen Triesch, Marlies Wagner, Matthew C Walker, Frederic von Wegner, Sebastian Bauer
Despite the availability of more than 15 new "antiepileptic drugs", the proportion of patients with pharmacoresistant epilepsy has remained constant at about 20-30%. Furthermore, no disease-modifying treatments shown to prevent the development of epilepsy following an initial precipitating brain injury or to reverse established epilepsy have been identified to date. This is likely in part due to the polyetiologic nature of epilepsy, which in turn requires personalized medicine approaches. Recent advances in imaging, pathology, genetics and epigenetics have led to new pathophysiological concepts and the identification of monogenic causes of epilepsy...
September 13, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28917500/economic-evaluation-of-childhood-epilepsy-in-a-resource-challenged-setting-a-preliminary-survey
#18
Aliyu Ibrahim, Umar Isa Umar, Umar Musa Usman, Lukman Femi Owolabi
BACKGROUND: Considerable disease variability exists between patients with epilepsy, and the societal costs for epilepsy care are overall high, because of high frequency in the general population especially in children from developing countries. MATERIALS AND METHODS: A cross-sectional study where children with established diagnosis of epilepsy were interviewed using a semi-structured questionnaire. Prevalence-based costs were stratified by patients' sociodemographic characteristics and socioeconomic scores (SES)...
September 13, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28917499/association-of-sleep-with-sudden-unexpected-death-in-epilepsy
#19
REVIEW
Ahmer Ali, Shasha Wu, Naoum P Issa, Sandra Rose, Vernon L Towle, Peter Warnke, James X Tao
OBJECTIVE: The objective of this study was to determine the association of sleep with sudden unexpected death in epilepsy (SUDEP). METHODS: We conducted a systematic review and meta-analysis based on literature search from databases PubMed, Web of Science, and Scopus using keywords "SUDEP", or "sudden unexpected death in epilepsy", or "sudden unexplained death in epilepsy". Sudden unexpected death in epilepsy was considered to occur during sleep if the patient was found in bed, if the SUDEP cases were documented as in sleep, or if the patient was found at bedside on the bedroom floor...
September 13, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28917498/personalized-translational-epilepsy-research-novel-approaches-and-future-perspectives-part-ii-experimental-and-translational-approaches
#20
REVIEW
Sebastian Bauer, Natascha van Alphen, Albert Becker, Andreas Chiocchetti, Ralf Deichmann, Thomas Deller, Thomas Freiman, Christine M Freitag, Johannes Gehrig, Anke M Hermsen, Peter Jedlicka, Christian Kell, Karl Martin Klein, Susanne Knake, Dimitri M Kullmann, Stefan Liebner, Braxton A Norwood, Diana Omigie, Karlheinz Plate, Andreas Reif, Philipp S Reif, Yvonne Reiss, Jochen Roeper, Michael W Ronellenfitsch, Stephanie Schorge, Gerhard Schratt, Stephan W Schwarzacher, Joachim P Steinbach, Adam Strzelczyk, Jochen Triesch, Marlies Wagner, Matthew C Walker, Frederic von Wegner, Felix Rosenow
Despite the availability of more than 15 new "antiepileptic drugs", the proportion of patients with pharmacoresistant epilepsy has remained constant at about 20-30%. Furthermore, no disease-modifying treatments shown to prevent the development of epilepsy following an initial precipitating brain injury or to reverse established epilepsy have been identified to date. This is likely in part due to the polyetiologic nature of epilepsy, which in turn requires personalized medicine approaches. Recent advances in imaging, pathology, genetics, and epigenetics have led to new pathophysiological concepts and the identification of monogenic causes of epilepsy...
September 13, 2017: Epilepsy & Behavior: E&B
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