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Epilepsy & Behavior: E&B

Teppei Matsubara, Katsuya Ogata, Naruhito Hironaga, Yoshikazu Kikuchi, Taira Uehara, Hiroshi Chatani, Takako Mitsudo, Hiroshi Shigeto, Shozo Tobimatsu
OBJECTIVE: Our previous study of monaural auditory evoked magnetic fields (AEFs) demonstrated that hippocampal sclerosis significantly modulated auditory processing in patients with mesial temporal lobe epilepsy (mTLE). However, the small sample size (n = 17) and focus on the M100 response were insufficient to elucidate the lateralization of the epileptic focus. Therefore, we increased the number of patients with mTLE (n = 39) to examine whether neural synchronization induced by monaural pure tone stimulation provides useful diagnostic information about epileptic foci in patients with unilateral mTLE...
September 19, 2018: Epilepsy & Behavior: E&B
Taylor Kuhn, Joseph M Gullett, Angelique E Boutzoukas, Anastasia Bohsali, Thomas H Mareci, David B FitzGerald, Paul R Carney, Russell M Bauer
Evidence for structural connectivity patterns within the medial temporal lobe derives primarily from postmortem histological studies. In humans and nonhuman primates, the parahippocampal gyrus (PHg) is subdivided into parahippocampal (PHc) and perirhinal (PRc) cortices, which receive input from distinct cortical networks. Likewise, their efferent projections to the entorhinal cortex (ERc) are distinct. The PHc projects primarily to the medial ERc (M-ERc). The PRc projects primarily to the lateral portion of the ERc (L-ERc)...
September 19, 2018: Epilepsy & Behavior: E&B
Lu-Wei Jiang, Ruo-Bing Qian, Xian-Ming Fu, Dong Zhang, Nan Peng, Chao-Shi Niu, Ye-Han Wang
PURPOSE: Epilepsy is considered a disorder of neural networks. Patients diagnosed with refractory epilepsy frequently experience attention impairments. Seizure activity in epilepsy may disturb brain networks and damage the brain function of attention. The aims of this study were to assess functional and causal connectivities of the attention networks and default mode network using resting-state functional magnetic resonance imaging (fMRI). METHOD: Resting-state fMRI data were gathered from 19 patients with refractory epilepsy (mixed localization and aetiologies) and 21 healthy people...
September 19, 2018: Epilepsy & Behavior: E&B
Shahram Etemadifar, Maryam Heidari, Nahid Jivad, Reza Masoudi
OBJECTIVES: Family caregivers face numerous challenges in taking care of their family members with epilepsy. The empowerment of this group of people, who can be described as forgotten patients, should always be considered through supportive interventions; therefore, this study investigated the effect of a family-centered intervention program on stress, anxiety, and depression among family caregivers of patients with epilepsy. METHODS: In 2017, a trial was conducted in Iran among subjects selected by the convenience sampling method and randomly assigned to two groups: intervention and control...
September 19, 2018: Epilepsy & Behavior: E&B
Selim R Benbadis, Eric Geller, Philippe Ryvlin, Steven Schachter, James Wheless, Werner Doyle, Fernando L Vale
For drug-resistant epilepsy, nonpharmacologic treatments should be considered early rather than late. Of the nondrug treatments, only resective surgery can be curative. Neurostimulation is palliative, i.e., not expected to achieve a seizure-free outcome. While resective surgery is the goal, other options are necessary because the majority of patients with drug-resistant epilepsy are not surgical candidates, and others have seizures that fail to improve with surgery or have only partial improvement but not seizure freedom...
September 18, 2018: Epilepsy & Behavior: E&B
Mayoura Bounlu, Emilie Auditeau, Somchit Vorachit, Phetvongsinh Chivorakoun, Vimalay Souvong, Noudy Sengxeu, Pierre-Marie Preux, Farid Boumediene
RELEVANCE: A low level of knowledge about epilepsy among health workers, a context of stigmatizing sociocultural beliefs, and a low availability of antiepileptic drugs in Lao People's Democratic Republic (PDR) are major gaps in the medical management of people with epilepsy in this country. OBJECTIVES: The principal objective of the study was to identify the associated factors of adherence to community healthcare structures in Lao PDR. Specific objectives were to evaluate patients' adherence status, practices and knowledge about epilepsy and its care, and factors influencing decision-making on therapeutic interventions...
September 18, 2018: Epilepsy & Behavior: E&B
Nancy L Reaven, Susan E Funk, Georgia D Montouris, Timothy B Saurer, Tyler J Story
OBJECTIVE: Lennox-Gastaut syndrome (LGS) is a severe and treatment-resistant epilepsy syndrome characterized by multiple subtypes of intractable seizures, moderate to severe cognitive impairment, and slow spike-wave complexes on electroencephalographic (EEG) recordings. Lennox-Gastaut syndrome is also associated with increased risk for injury, reduced quality of life, long-term disability, and early mortality. By evaluating private and public US medical insurance claims, we quantified healthcare utilization and direct costs in patients with possible LGS...
September 18, 2018: Epilepsy & Behavior: E&B
Matthieu Perrenoud, Pascal André, Thierry Buclin, Laurent A Decosterd, Andrea O Rossetti, Jan Novy
INTRODUCTION: Intravenous levetiracetam (LEV) is broadly used in the treatment of status epilepticus (SE). A loading dose is usually infused, aiming to reach quickly the range of plasma concentrations considered as therapeutic (12-46 mg/l). The aim of the study was to evaluate the response to LEV in SE, correlated exposure assessed by plasma concentration monitoring, as well as calculated exposure parameters. MATERIALS & METHODS: We retrospectively analyzed a SE registry, including patients since 2015 with at least one available LEV plasma level measured less than 36 h after loading...
September 18, 2018: Epilepsy & Behavior: E&B
Bertrand de Toffol, Michael Trimble, Dale C Hesdorffer, Lauren Taylor, Perminder Sachdev, Maurice Clancy, Naoto Adachi, José Augusto Bragatti, Marco Mula, Kousuke Kanemoto
The recognition and treatment of psychosis in persons with epilepsy (PWE) is recommended with the apparent dilemma between treating psychosis and opening the possibility of exacerbating seizures. The pooled prevalence estimate of psychosis in PWE is 5.6%. It has been proposed that a 'two hit' model, requiring both aberrant limbic activity and impaired frontal control, may account for the wide range of clinical phenotypes. The role of antiepileptic drugs in psychosis in PWE remains unclear. Alternating psychosis, the clinical phenomenon of a reciprocal relationship between psychosis and seizures, is unlikely to be an exclusively antiepileptic drug-specific phenomenon but rather, linked to the neurobiological mechanisms underlying seizure control...
September 18, 2018: Epilepsy & Behavior: E&B
Leman İnanç, Yasemin Ünal, Ümit Başar Semiz, Gülnihal Kutlu
PURPOSE: We aimed to study the relationship between the mentalizing ability and stigma in patients with epilepsy. METHODS: Patients with epilepsy were administered the following battery of tests: Mini-International Neuropsychiatric Interview (MINI) form, Reading the Mind in the Eyes Test (Eyes Test), Stigma Scale of Epilepsy (SSE), Internalized Stigma of Mental Illness (ISMI) Scale, Beck Depression Inventory (BDI), and Beck Anxiety Inventory (BAI). RESULTS: Assessment of an association between the Eyes Test score, ISMI Scale total score, and subscale scores revealed a negative significant correlation of Eyes Test scores with approval of stereotypes, perceived discrimination, stigma resistance, and total score...
September 18, 2018: Epilepsy & Behavior: E&B
Kirsten Labudda, Michael Frauenheim, Dominik Illies, Inga Miller, Mario Schrecke, Nadine Vietmeier, Christian Brandt, Christian G Bien
Several studies found high prevalence rates of psychiatric disorders in patients with pure psychogenic nonepileptic seizures (PNES). Traumatic experiences were also reported to be elevated in patients with PNES and were discussed as a crucial risk factor for the development of PNES. Much less is known about psychiatric comorbidities and specifically, about trauma history in patients with PNES and coexisting epilepsy. Here, we aimed at directly comparing psychiatric disorders and traumatic life experiences in patients with pure PNES and in patients with PNES and coexisting epilepsy...
September 18, 2018: Epilepsy & Behavior: E&B
Nadine Conradi, Anke Hermsen, Kristina Krause, Iris Gorny, Adam Strzelczyk, Susanne Knake, Felix Rosenow
Since its introduction, functional transcranial Doppler sonography (fTCD) has been extensively applied in research and clinical settings and has now become part of the routine presurgical work-up of patients with epilepsy. Because of its importance in planning neurosurgical interventions and predicting possible cognitive risks, the reproducibility of fTCD in determining hemispheric language lateralization (HLL) has to be ensured. In the present study, fTCD was performed twice in 33 initially lateralized patients with temporal lobe epilepsy (TLE) as part of their presurgical work-up, using a standard word generation paradigm...
September 11, 2018: Epilepsy & Behavior: E&B
Zachary J Waldman, Liliana Camarillo-Rodriguez, Inna Chervenova, Brent Berry, Shoichi Shimamoto, Bahareh Elahian, Michal Kucewicz, Chaitanya Ganne, Xiao-Song He, Leon A Davis, Joel Stein, Sandhitsu Das, Richard Gorniak, Ashwini D Sharan, Robert Gross, Cory S Inman, Bradley C Lega, Kareem Zaghloul, Barbara C Jobst, Katheryn A Davis, Paul Wanda, Mehraneh Khadjevand, Joseph Tracy, Daniel S Rizzuto, Gregory Worrell, Michael Sperling, Shennan A Weiss
BACKGROUND: We sought to determine if ripple oscillations (80-120 Hz), detected in intracranial electroencephalogram (iEEG) recordings of patients with epilepsy, correlate with an enhancement or disruption of verbal episodic memory encoding. METHODS: We defined ripple and spike events in depth iEEG recordings during list learning in 107 patients with focal epilepsy. We used logistic regression models (LRMs) to investigate the relationship between the occurrence of ripple and spike events during word presentation and the odds of successful word recall following a distractor epoch and included the seizure onset zone (SOZ) as a covariate in the LRMs...
September 11, 2018: Epilepsy & Behavior: E&B
Rosa Michaelis, Helmut Schöller, Yvonne Höller, Gudrun Kalss, Margarita Kirschner, Elisabeth Schmid, Eugen Trinka, Günter Schiepek
BACKGROUND: Admission to the epilepsy monitoring unit (EMU) for long-term video-electroencephalography (EEG) monitoring (VEEG) constitutes the gold standard for seizure diagnosis and presurgical evaluation. This study applied the concept of a high-frequency systematic monitoring of psychological states and tested patients' compliance in order to evaluate if its integration in the EMU is feasible and if patients benefit from the graphically underpinned discussion of their EMU stay-related cognitions and emotions...
September 10, 2018: Epilepsy & Behavior: E&B
Viola L Vogt, Juri-Alexander Witt, Daniel Delev, Alexander Grote, Marec von Lehe, Albert J Becker, Johannes Schramm, Christian E Elger, Christoph Helmstaedter
OBJECTIVE: The objective of the study was to evaluate cognitive and epilepsy-related features in 166 surgically treated patients with epilepsy with long-term epilepsy-associated tumors (LEATs) located in the temporal lobe. METHOD: Pre- and postsurgical cognitive as well as the one-year seizure outcome of adult patients with histopathologically confirmed LEATs (28 grade-I dysembryoplastic neuroepithelial tumors (DNET), 95 grade-I gangliogliomas (GG), 24 grade-I pilocytic astrocytomas (PA), 9 grade-II pleomorphic xanthoastrocytoma (PXA), 10 grade-II diffuse astrocytoma (DA)) who underwent epilepsy surgery in Bonn/Germany between 1988 and 2012 were evaluated...
September 10, 2018: Epilepsy & Behavior: E&B
Ferhat Balgetir, Bülent Müngen, Murat Gönen, Eren Müngen, İrem Taşcı
No abstract text is available yet for this article.
September 10, 2018: Epilepsy & Behavior: E&B
Emilio Verche, Concepción San Luis, Sergio Hernández
Frontal lobe epilepsy (FLE) is associated with cognitive problems, especially in areas related to frontal lobe functioning as executive functions, attention, and motor skills, but with impact on memory and psychosocial adaptation. Deficits are similar in both adults and children with FLE, although no studies have compared adult and pediatric performance in the same study. The aim of this research was to analyze the existing evidence concerning the cognition in adults and children with FLE. A random effect meta-analysis was used using Cohen's d, and the confidence interval for each cognitive factor was calculated...
September 10, 2018: Epilepsy & Behavior: E&B
Julia Oppenheimer, Alan Leviton, Madeline Chiujdea, Annalee Antonetty, Oluwafemi William Ojo, Stephanie Garcia, Sarah Weas, Eric W Fleegler, Eugenia Chan, Tobias Loddenkemper
PURPOSE: The purpose of this study was to review electronic tools that might improve the delivery of epilepsy care, reduce medical care costs, and empower families to improve self-management capability. METHOD: We reviewed the epilepsy-specific literature about self-management, electronic patient-reported or provider-reported outcomes, on-going remote surveillance, and alerting/warning systems. CONCLUSIONS: The improved care delivery system that we envision includes self-management, electronic patient (or provider)-reported outcomes, on-going remote surveillance, and alerting/warning systems...
September 6, 2018: Epilepsy & Behavior: E&B
Samuel Gittins, Dora Steel, Andreas Brunklaus, Imogen Newsom-Davis, Christina Hawkins, Sarah E Aylett
Sturge-Weber syndrome (SWS) is a neurocutaneous disorder characterized by the combination of a facial naevus flammeus and pial angioma, often associated with learning difficulties and/or epilepsy. Here, we report on the neuropsychological characteristics of a cohort of 92 children with SWS seen at a national referral center between 2002 and 2015. Almost a quarter (24%) had a diagnosis of autism spectrum disorder (ASD), with 45% overall having evidence of social communication difficulties (SCD). Autism spectrum disorder was more commonly seen in those individuals with bilateral angioma (p = 0...
September 6, 2018: Epilepsy & Behavior: E&B
Santoshi Billakota, Nicole Odom, Andrew J Westwood, Eric Hanna, Alison M Pack, Lisa M Bateman
INTRODUCTION: Sudden unexpected death in epilepsy (SUDEP) is a major contributor to epilepsy-related mortality. It is associated with nocturnal seizures and centrally mediated postictal cardiorespiratory dysfunction (CRD), but mechanisms and contributors remain poorly understood. METHODS: We performed a prospective, cross-sectional, observational pilot study in the Columbia University Medical Center (CUMC) adult epilepsy monitoring unit (EMU) to explore relationships between periictal CRD, sleep-disordered breathing (SDB), neuroendocrine function, and clinical SUDEP risk...
August 31, 2018: Epilepsy & Behavior: E&B
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