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Epilepsy & Behavior: E&B

Phani Kumar Kola, Annapurna Akula, Lakshmi Sudeepthi Nissankara Rao, Ravi Chandra Sekhara Reddy Danduga, Abutalaha Mohammad, Srikanth Ineedi
Phenytoin (Dilantin) is an orally active, use-dependent voltage-gated sodium channel inhibitor and is a potent, economical, and widely used anticonvulsant agent. The objective of the present study was to investigate the effect of the combined treatment of naringin (40 mg/kg and 80 mg/kg) and phenytoin on prevention of seizure attacks, development of kindling, oxidative stress, cognitive impairment, and neurochemicals in the frontal cortex, temporal cortex, and hippocampus, and morphological changes in the hippocampus...
November 8, 2018: Epilepsy & Behavior: E&B
Katie L Reger, Abigail Hughes-Scalise, Maureen A O'Connor
Approximately 50% of patients diagnosed with epilepsy in childhood will need treatment in adulthood. Transition from pediatric to adult epilepsy care is challenging, and an unsuccessful transition can have detrimental effects. Researchers emphasize the importance of addressing possible barriers to transition in a multidisciplinary setting. In this paper, we describe a transition program implemented in a Level 4 epilepsy center in the Midwest. This program involves a psychosocial multidisciplinary team including a pediatric neuropsychologist, pediatric psychologist, and social worker who meet jointly with patient and his/her caregiver(s) before and after the transition...
November 8, 2018: Epilepsy & Behavior: E&B
Jiahe Lin, Xinshi Wang, Feirong Dong, Yanru Du, Jingzan Shen, Siqi Ding, Li Wang, Mengqian Ye, Yi Wang, Niange Xia, Rongyuan Zheng, Hong Chen, Huiqin Xu
OBJECTIVE: This study aimed to validate the Chinese version of the 17-item Hamilton Rating Scale for Depression (C-HRSD-17) for use in adult patients with epilepsy (PWE). METHODS: A consecutive sample of Chinese adult PWE from a tertiary hospital was examined using the C-HRSD-17 and the Mini International Neuropsychiatric Interview (MINI) Plus Chinese Version 5.0.0. RESULTS: A total of 191 PWE completed the assessment of depression. According to the MINI, thirty patients (15...
November 8, 2018: Epilepsy & Behavior: E&B
Tushar D Gosavi, Stella Wang, Siew Ju See, John Ng, Shih Hui Lim
A survey to assess the familiarity, attitudes, and knowledge about epilepsy was done using a questionnaire identical to the one used in 1999. Two hundred forty-six people participated in our survey in 2017 as compared with 214 in the 1999 survey. In terms of familiarity about epilepsy, 76% had heard or read about epilepsy, 55.7% had witnessed a seizure, and 35.8% knew someone with epilepsy (85%, 56%, and 36% respectively in 1999). Forty point five percent were not familiar with or did not know what to do if they witnessed a seizure (44% in 1999); 25...
November 8, 2018: Epilepsy & Behavior: E&B
Lauren B Bolden, Joseph C Griffis, Rodolphe Nenert, Jane B Allendorfer, Jerzy P Szaflarski
We recently found that higher cortical excitability is associated with poorer attention performance in healthy adults. While patients with idiopathic generalized epilepsies (IGEs), previously termed genetic generalized epilepsies, are known to demonstrate increased cortical excitability and cognitive deficits, a relationship between these variables in IGEs has not been investigated. Therefore, we aimed to characterize the effects of cortical excitability and seizure control on cognitive performance in IGEs...
November 8, 2018: Epilepsy & Behavior: E&B
Meltem Korucuk, Sibel Gazioglu, Ahmet Yildirim, Evrim Ozkorumak Karaguzel, Sibel K Velioglu
Psychogenic nonepileptic seizures (PNES) are more prevalent among women, and diagnosis may sometimes be delayed by as much as seven years. Understanding the effect of gender on the presentation of a PNES may assist with diagnosis based on semiological details in the clinical setting. Although video-EEG monitoring (VEM) is the gold standard for diagnosing PNES, determining gender-related seizure semiology through careful history may prevent diagnostic delay while waiting for VEM. The aim of this study was to investigate gender-related differences in the semiology of PNES...
November 8, 2018: Epilepsy & Behavior: E&B
Ann Little, Mary Secco, Jacob Mugumbate
No abstract text is available yet for this article.
November 7, 2018: Epilepsy & Behavior: E&B
Frank John Emery Vajda, Terence John O'Brien, Janet Elizabeth Graham, Alison Anne Hitchcock, Raphael John Paul Kuhn, Cecilie Margaret Lander, Mervyn John Eadie
The literature suggests that cesarean delivery or birth is carried out more often in pregnant women with epilepsy (WWE) than in pregnant women in the general population. Data were utilized from the Australian Pregnancy Register (APR) for Women on Antiepileptic Medication to investigate this issue in Australia. Over almost two decades, the mean CS rate in 1900 APR women was 39.2%, but was only 29.9% in women in the general population (relative risk (R.R.) = 1.31, 95% confidence interval (C.I.) 1.24, 1.39)...
November 7, 2018: Epilepsy & Behavior: E&B
Sungtae An, Kunal Malhotra, Cynthia Dilley, Edward Han-Burgess, Jeffrey N Valdez, Joseph Robertson, Chris Clark, M Brandon Westover, Jimeng Sun
Patients with drug-resistant epilepsy (DRE) are at high risk of morbidity and mortality, yet their referral to specialist care is frequently delayed. The ability to identify patients at high risk of DRE at the time of treatment initiation, and to subsequently steer their treatment pathway toward more personalized interventions, has high clinical utility. Here, we aim to demonstrate the feasibility of developing algorithms for predicting DRE using machine learning methods. Longitudinal, intersected data sourced from US pharmacy, medical, and adjudicated hospital claims from 1,376,756 patients from 2006 to 2015 were analyzed; 292,892 met inclusion criteria for epilepsy, and 38,382 were classified as having DRE using a proxy measure for drug resistance...
November 6, 2018: Epilepsy & Behavior: E&B
Colin Reilly, Patricia Atkinson, Ayesha Memon, Chloe Jones, Lyvia Dabydeen, Krishna B Das, J Helen Cross, Brian G R Neville, Christopher Gillberg, Rod C Scott
The aim was to provide data on parenting stress and perceived stigma in mothers (n = 47) of young children with epilepsy, and to compare findings with those of mothers (n = 48) of developmental, age- and gender-matched children with nonepilepsy-related neurodisability (neurological and/or neurodevelopmental concerns). The mothers of young children (1-7 years) with epilepsy and mothers of children with neurodisability in a defined geographical area of the UK, completed the Parenting Stress Index-4th Edition (PSI-4) and a measure of perceived stigma...
November 6, 2018: Epilepsy & Behavior: E&B
Belén Abarrategui, Beatriz Parejo-Carbonell, Maria Eugenia García García, Daniela Di Capua, Irene García-Morales
OBJECTIVE: Dysexecutive traits have been described in idiopathic generalized epilepsy (IGE), but studies mainly focused on juvenile myoclonic epilepsy (JME). To better understand the neuropsychology of IGE, more research is needed on syndromes other than JME, controlling potential confounding factors as the cognitive effects of valproate and epileptic discharges (ED). We describe the neuropsychological profile of a group of patients with different syndromes of IGE including simultaneous video electroencephalography (EEG)...
November 5, 2018: Epilepsy & Behavior: E&B
Niels Hansen, Guido Widman, Svenja Stuff, Albert J Becker, Juri-Alexander Witt, Hojjat Ahmadzadehfar, Christoph Helmstaedter, Christian E Elger
OBJECTIVE: Paraneoplastic limbic encephalitis (LE) occurs frequently with considerable variability according to literature reports. We thus determined the cancer frequency in mixed LE subtypes sharing the diagnosis of temporal lobe epilepsy (TLE). METHODS: All patients underwent magnetic resonance imaging (MRI) of the brain, electroencephalography (EEG) recordings, neuropsychological testing, immunohistochemistry, and clinical examination together with whole body 2-fluor-2-desoxy-d-glucose (FDG)-positron emission tomography (PET)/computed tomography (CT) to detect cancer in this observatory study...
November 5, 2018: Epilepsy & Behavior: E&B
Hannah Purtell, Sameer C Dhamne, Sarika Gurnani, Elizabeth Bainbridge, Meera E Modi, Stephen H T Lammers, Chloe E Super, Mustafa Q Hameed, Ervin L Johnson, Mustafa Sahin, Alexander Rotenberg
High-voltage rhythmic electroencephalographic (EEG) spikes have been recorded in wildtype (WT) rats during periods of light slow-wave sleep and passive wakefulness. The source of this activity is unclear but has been attributed to either an inherent form of absence epilepsy or a normal feature of rodent sleep EEG. In contrast, little is known about epileptiform spikes in WT mice. We thus characterize and quantify epileptiform discharges in WT mice for the first time. Thirty-six male WT C57 mice with 24-h wireless telemetry video-EEG recordings were manually scored by blinded reviewers to mark individual spikes and spike trains...
November 3, 2018: Epilepsy & Behavior: E&B
Steven Owens, Joseph I Sirven, Patricia O Shafer, Jesse Fishman, Imane Wild, Mark Findley, Russell Derry, Jenniafer Walters, Vicki Kopplin, Jody Kakacek
OBJECTIVE: The Connectors Project, a collaboration between the Epilepsy Foundation and UCB Pharma, was a multiyear project designed to improve epilepsy care in underserved communities. A core objective of the Connectors Project was to pilot new and innovative approaches to epilepsy awareness and education in rural and underserved areas, including standardized curricula for healthcare providers and patients. METHODS: A series of consensus conferences explored opportunities and barriers to epilepsy care throughout the United States including access to local Epilepsy Foundations, neurologists, and epilepsy centers...
October 31, 2018: Epilepsy & Behavior: E&B
Susanne Schubert-Bast, Laurent M Willems, Gerhard Kurlemann, Susanne Knake, Karen Müller-Schlüter, Felix Rosenow, Adam Strzelczyk
INTRODUCTION: This multicenter, retrospective study aimed to evaluate the efficiency, retention, safety, and tolerability of brivaracetam (BRV) in children and adolescents with focal epilepsy. METHODS: All patients aged ≤17 years with focal epilepsy who started BRV in 2016 and 2017 were analyzed. RESULTS: Thirty-four patients (mean age: 12.2 years, range: 3-17 years, 56% female) were treated with BRV for 25 days to 24 months, with a total exposure time of 19...
October 31, 2018: Epilepsy & Behavior: E&B
Kristen Malloy, Damon Cardenas, August Blackburn, Luke Whitmire, Jose E Cavazos
OBJECTIVE: There is a high cost associated with recording quality video and electroencephalography (EEG) data in National Association of Epilepsy Center (NAEC) level IV epilepsy monitoring units (EMU). This study considers potential quality measures in EMUs for generalized tonic-clonic (GTC) seizures: types of safety signals, response time, and visibility of patient's limbs for semiology. These quality measures have been summarized across 12 EMUs to estimate response times to GTC seizures and the quality of video data that is captured during admissions...
October 30, 2018: Epilepsy & Behavior: E&B
Qin Zhao, Man Wang, Huicong Kang, Suiqiang Zhu
In this study, we aimed to evaluate the prevalence of attention-deficit hyperactivity disorder (ADHD) in children with epilepsy in Central China and compare the behavioral problems in children with epilepsy combined with and without ADHD. Children with epilepsy aged between 6 and 16 years were recruited for this study. Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria were administered for the diagnosis of ADHD and ADHD subtype in children with epilepsy. Children Behavior Checklist (CBCL) was administered by trained research assistants to evaluate children's behavior problems...
October 30, 2018: Epilepsy & Behavior: E&B
Martha Sajatovic, Kelley Needham, Kari Colón-Zimmermann, Nicole Richter, Hongyan Liu, John Garrity, Eleanor R Ryan, Norma Storer, Valeria Harper
AIMS: Comorbid mental health conditions (MHCs) such as depression and anxiety are common in people with epilepsy. Targeted Self-Management for Epilepsy and Mental Illness (TIME) is a behavioral program that targets mood symptoms in adults with epilepsy and comorbid MHCs. Building upon positive findings of a randomized controlled study to establish the efficacy of TIME, the Community-TIME (C-TIME) initiative assessed the implementation feasibility and pre-/post-outcomes of this new evidence-based epilepsy self-management intervention in a community setting and in collaboration with key stakeholders...
October 29, 2018: Epilepsy & Behavior: E&B
Mansur A Kutlubaev, Ying Xu, Maree L Hackett, Jon Stone
Comorbid epilepsy and psychogenic nonepileptic seizures (PNES) represent a serious challenge for the clinicians. However, the frequency, associations, and outcomes of dual diagnosis of epilepsy and PNES are unclear. The aim of the review was to determine the frequency, correlates, and outcomes of a dual diagnosis. A systematic review of all published observational studies (from inception to Dec. 2016) was conducted to determine the frequency, correlates, and outcomes of dual diagnosis. We included studies of individuals of any age reporting a dual diagnosis of epilepsy and PNES...
October 29, 2018: Epilepsy & Behavior: E&B
Jessica Willis, Lauren Hophing, Nadilein Mahlberg, Gabriel M Ronen
PURPOSE: We aimed to explore (i) the impact that a motivated walking program had on youth with epilepsy and (ii) the facilitators and barriers to implementing and sustaining the program. METHODS: Data were gathered using semi-structured interviews with the intervention group of a randomized controlled trial to study the effect of enhanced physical activity on youth with epilepsy. Participants had active epilepsy and were 8-14 years at recruitment. All wore an activity tracker for a year and received coaching via phone calls during the first six months to encourage reaching a step goal, which they then attempted to maintain independently for the following six months...
October 27, 2018: Epilepsy & Behavior: E&B
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