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Journal of the Association for Research in Otolaryngology: JARO

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https://www.readbyqxmd.com/read/30377852/interaction-between-pitch-and-timbre-perception-in-normal-hearing-listeners-and-cochlear-implant-users
#1
Xin Luo, Samara Soslowsky, Kathryn R Pulling
Despite their mutually exclusive definitions, pitch and timbre perception interact with each other in normal-hearing (NH) listeners. Cochlear implant (CI) users have worse than normal pitch and timbre perception. However, the pitch-timbre interaction with CIs is not well understood. This study tested the interaction between pitch and sharpness (an aspect of timbre) perception related to the fundamental frequency (F0) and spectral slope of harmonic complex tones, respectively, in both NH listeners and CI users...
October 30, 2018: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/30341698/study-of-the-mechanisms-by-which-aminoglycoside-damage-is-prevented-in-chick-embryonic-hair-cells
#2
Huanju Bai, Xi Wang, Xue Gao, Jie Bing, Weiqian Wang, Xuebo Zhang, Chao Xi, Lingling Jiang, Xinwen Zhang, Zhongming Han, Shaoju Zeng, Jincao Xu
A major side effect of aminoglycoside antibiotics is mammalian hair cell death. It is thus intriguing that embryonic chick hair cells treated with aminoglycosides at embryonic day (E) 12 are insensitive to ototoxicity. To exclude some unknown factors in vivo that might be involved in preventing aminoglycoside damage to embryonic hair cells, we first cultured chick embryonic basilar papilla (BP) with an aminoglycoside antibiotic in vitro. The results indicated that the hair cells were almost intact at E12 and E14 and were only moderately damaged in most parts of the BP at E16 and E18...
October 18, 2018: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/30341699/amplitude-modulation-detection-in-children-with-a-history-of-temporary-conductive-hearing-loss-remains-impaired-for-years-after-restoration-of-normal-hearing
#3
Margo McKenna Benoit, Mark Orlando, Kenneth Henry, Paul Allen
Otitis media with effusion (OME) is considered a form of relative sensory deprivation that often occurs during a critical period of language acquisition in children. Animal studies have demonstrated that hearing loss during early development can impair behavioral sensitivity to amplitude modulation (AM), critical for speech understanding, even after restoration of normal hearing thresholds. AM detection in humans with a history of OME-associated conductive hearing loss (CHL) has not been previously investigated...
October 17, 2018: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/30264229/interaural-time-difference-perception-with-a-cochlear-implant-and-a-normal-ear
#4
Tom Francart, Konstantin Wiebe, Thomas Wesarg
Currently there is a growing population of cochlear-implant (CI) users with (near) normal hearing in the non-implanted ear. This configuration is often called SSD (single-sided deafness) CI. The goal of the CI is often to improve spatial perception, so the question raises to what extent SSD CI listeners are sensitive to interaural time differences (ITDs). In a controlled lab setup, sensitivity to ITDs was investigated in 11 SSD CI listeners. The stimuli were 100-pps pulse trains on the CI side and band-limited click trains on the acoustic side...
September 27, 2018: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/30251187/human-vestibulo-ocular-reflex-adaptation-training-time-beats-quantity
#5
M Muntaseer Mahfuz, Michael C Schubert, William V C Figtree, Christopher J Todd, Americo A Migliaccio
The vestibulo-ocular reflex (VOR) is the main gaze stabilising system during rapid head movements. The VOR is highly plastic and its gain (eye/head velocity) can be increased via training that induces an incrementally increasing retinal image slip error signal to drive VOR adaptation. Using the unilateral incremental VOR adaptation technique and horizontal active head impulses as the vestibular stimulus, we sought to determine the factors important for VOR adaptation including: the total training time, ratio and number of head impulses to each side (adapting and non-adapting sides; the adapting side was pseudo-randomised left or right) and exposure time to the visual target during each head impulse...
September 24, 2018: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/30238407/the-masked-abr-mabr-a-new-measurement-method-for-the-auditory-brainstem-response
#6
Christian Brandt, Nanna Brande-Lavridsen, Jakob Christensen-Dalsgaard
The auditory brainstem response (ABR) is relatively non-invasive, and in many species, the only practical way to assess auditory sensitivity. The two main methods for measuring ABR are using either transients or tone bursts as a stimulus. The transient stimulus produces strong neural responses that contain no frequency information. In contrast, tone bursts stimulate only a small part of the auditory system, eliciting weaker neural responses but supplying frequency information. Furthermore, short tone bursts become less and less frequency specific with increasing stimulus wavelength, making them unsuitable for testing low-frequency hearing...
September 20, 2018: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/30232712/evaluation-of-possible-effects-of-a-potassium-channel-modulator-on-temporal-processing-by-cochlear-implant-listeners
#7
Robert P Carlyon, John M Deeks, François Guérit, Wiebke Lamping, Alexander J Billig, Charles H Large, Shakeel R Saeed, Peter Harris
Temporal processing by cochlear implant listeners is degraded and is affected by auditory deprivation. The fast-acting Kv3.1 potassium channel is important for sustained temporally accurate firing and is also susceptible to deprivation, the effects of which can be partially restored in animals by the molecule AUT00063. We report the results of a randomised placebo-controlled double-blind study on psychophysical tests of the effects of AUT00063 on temporal processing by CI listeners. The study measured the upper limit of temporal pitch, gap detection, and discrimination of low rates (centred on 120 pps) for monopolar pulse trains presented to an apical electrode...
September 19, 2018: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/30191426/the-stress-response-in-the-non-sensory-cells-of-the-cochlea-under-pathological-conditions-possible-role-in-mediating-noise-vulnerability
#8
Anni Herranen, Kuu Ikäheimo, Jussi Virkkala, Ulla Pirvola
Various stressors, such as loud sounds and the effects of aging, impair the function and viability of the cochlear sensory cells, the hair cells. Stressors trigger pathophysiological changes in the cochlear non-sensory cells as well. We have here studied the stress response mounted in the lateral wall of the cochlea during acute noise stress and during age-related chronic stress. We have used the activation of JNK/c-Jun, ERK, and NF-κB pathways as a readout of the stress response, and the expression of the FoxO3 transcription factor as a possible additional player in cellular stress...
September 6, 2018: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/30191425/noise-induced-hypersensitization-of-the-acoustic-startle-response-in-larval-zebrafish
#9
Ashwin A Bhandiwad, David W Raible, Edwin W Rubel, Joseph A Sisneros
Overexposure to loud noise is known to lead to deficits in auditory sensitivity and perception. We studied the effects of noise exposure on sensorimotor behaviors of larval (5-7 days post-fertilization) zebrafish (Danio rerio), particularly the auditory-evoked startle response and hearing sensitivity to acoustic startle stimuli. We observed a temporary 10-15 dB decrease in startle response threshold after 18 h of flat-spectrum noise exposure at 20 dB re·1 ms-2 . Larval zebrafish also exhibited decreased habituation to startle-inducing stimuli following noise exposure...
September 6, 2018: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/30191424/surface-motion-of-tympanic-membrane-in-a-chinchilla-model-of-acute-otitis-media
#10
Xuelin Wang, Rong Z Gan
The conductive hearing loss caused by acute otitis media (AOM) is commonly related to a reduction of the tympanic membrane (TM) mobility in response to sound stimuli. However, spatial alterations of the TM surface motion associated with AOM have rarely been addressed. In this study, the TM surface motion was determined using scanning laser Doppler vibrometry (SLDV) in a chinchilla model of AOM. The AOM was established by transbullar injection of nontypeable Haemophilus influenzae. The TM surface vibration was measured in control (uninfected) animals and two AOM groups of animals: 4 days (4D) and 8 days (8D) post inoculation...
September 6, 2018: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/30191423/improved-neural-coding-of-itd-with-bilateral-cochlear-implants-by-introducing-short-inter-pulse-intervals
#11
Brian D Buechel, Kenneth E Hancock, Yoojin Chung, Bertrand Delgutte
Bilateral cochlear implant (CI) users have poor perceptual sensitivity to interaural time differences (ITDs), which limits their ability to localize sounds and understand speech in noisy environments. This is especially true for high-rate (> 300 pps) periodic pulse trains, which are used as carriers in CI processors. Here, we investigate a novel stimulation strategy in which extra pulses are added to high-rate periodic pulse trains to introduce short inter-pulse intervals (SIPIs). We hypothesized that SIPIs can improve neural ITD sensitivity similarly to the effect observed by randomly jittering IPIs (Hancock et al...
September 6, 2018: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/30187298/otoprotective-effects-of-stephania-tetrandra-s-moore-herb-isolate-against-acoustic-trauma
#12
Yan Yu, Bing Hu, Jianxin Bao, Jessica Mulvany, Eric Bielefeld, Ryan T Harrison, Sarah A Neton, Partha Thirumala, Yingying Chen, Debin Lei, Ziyu Qiu, Qingyin Zheng, Jihao Ren, Maria Cristina Perez-Flores, Ebenezer N Yamoah, Pezhman Salehi
Noise is the most common occupational and environmental hazard, and noise-induced hearing loss (NIHL) is the second most common form of sensorineural hearing deficit. Although therapeutics that target the free-radical pathway have shown promise, none of these compounds is currently approved against NIHL by the United States Food and Drug Administration. The present study has demonstrated that tetrandrine (TET), a traditional Chinese medicinal alkaloid and the main chemical isolate of the Stephania tetrandra S...
September 5, 2018: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/30182318/correction-to-effect-of-stimulus-polarity-on-detection-thresholds-in-cochlear-implant-users-relationships-with-average-threshold-gap-detection-and-rate-discrimination
#13
Robert P Carlyon, Stefano Cosentino, John M Deeks, Wendy Parkinson, Julie G Arenberg
The middle initial of Julie G. Arenberg's name was incorrect in the original publication; it is correct as displayed here.
September 4, 2018: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/30171386/intracochlear-sound-pressure-measurements-in-normal-human-temporal-bones-during-bone-conduction-stimulation
#14
Christof Stieger, Xiying Guan, Rosemary B Farahmand, Brent F Page, Julie P Merchant, Defne Abur, Hideko Heidi Nakajima
Bone conduction (BC) is heavily relied upon in the diagnosis and treatment of hearing loss, but is poorly understood. For example, the relative importance and frequency dependence of various identified BC sound transmission mechanisms that contribute to activate the cochlear partition remain unknown. Recently, we have developed techniques in fresh human cadaveric specimens to directly measure scalae pressures with micro-fiberoptic sensors, enabling us to monitor the input pressure drive across the cochlear partition that triggers the cochlear traveling wave during air conduction (AC) and round-window stimulation...
August 31, 2018: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/30171385/effects-of-3-3-iminodipropionitrile-on-hair-cell-numbers-in-cristae-of-cba-caj-and-c57bl-6j-mice
#15
Brent A Wilkerson, Filippo Artoni, Colby Lea, Kayla Ritchie, Catherine A Ray, Olivia Bermingham-McDonogh
This study examines absolute hair cell numbers in the cristae of C57BL/6J mice and CBA/CaJ mice from weaning to adulthood as well as the dose required for 3,3'-iminodiproprionitrile (IDPN)-injury of the cristae in C57BL/6J mice and CBA/CaJ mice, the two mouse strains most commonly used by inner ear researchers. In cristae of CBA/CaJ and C57BL/6J mice, no loss of hair cells was observed up to 24 weeks. In both strains, dose-dependent loss of hair cells was observed 7 days after IDPN treatment of 2-month-old mice (IC50  = 16...
August 31, 2018: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/30128623/effects-of-masker-envelope-fluctuations-on-the-temporal-effect
#16
Skyler G Jennings, Kayla Sivas, Caitlin Stone
Under certain conditions, detection thresholds in simultaneous masking improve when the onset of a short sinusoidal probe is delayed from the onset of a long masker. This improvement, known as the temporal effect, is largest for broadband maskers and is smaller or absent for narrowband maskers centered on the probe frequency. This study tests the hypothesis that small or absent temporal effects for narrowband maskers are due to the inherent temporal envelope fluctuations of Gaussian noise. Temporal effects were measured for narrowband noise maskers with fluctuating ("fluctuating maskers") and flattened ("flattened maskers") temporal envelopes as a function of masker level (Exp...
August 20, 2018: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/30120621/human-vestibulo-ocular-reflex-adaptation-consolidation-time-between-repeated-training-blocks-improves-retention
#17
M Muntaseer Mahfuz, Michael C Schubert, William V C Figtree, Christopher J Todd, Americo A Migliaccio
We sought to determine if separating vestibulo-ocular reflex (VOR) adaptation training into training blocks with a consolidation (rest) period in between repetitions would result in improved VOR adaptation and retention. Consolidation of motor learning refers to the brain benefitting from a rest period after prior exposure to motor training. The role of consolidation on VOR adaptation is unknown, though clinicians often recommend rest periods as a part of vestibular rehabilitation. The VOR is the main gaze stabilising system during rapid head movements...
August 17, 2018: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/30076555/correction-to-aminoglycoside-damage-and-hair-cell-regeneration-in-the-chicken-utricle
#18
Mirko Scheibinger, Daniel C Ellwanger, C Eduardo Corrales, Jennifer S Stone, Stefan Heller
This article was updated to correct a formatting error in Table 1.
August 2018: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/30014309/spectral-ripples-in-round-window-cochlear-microphonics-evidence-for-multiple-generation-mechanisms
#19
Karolina K Charaziak, Jonathan H Siegel, Christopher A Shera
The cochlear microphonic (CM) results from the vector sum of outer hair cell transduction currents excited by a stimulus. The classical theory of CM generation-that the response measured at the round window is dominated by cellular sources located within the tail region of the basilar membrane (BM) excitation pattern-predicts that CM amplitude and phase vary little with stimulus frequency. Contrary to expectations, CM amplitude and phase-gradient delay measured in response to low-level tones in chinchillas demonstrate a striking, quasiperiodic pattern of spectral ripples, even at frequencies > 5 kHz, where interference with neurophonic potentials is unlikely...
August 2018: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/29869048/platelet-derived-growth-factor-subunit-b-signaling-promotes-pericyte-migration-in-response-to-loud-sound-in-the-cochlear-stria-vascularis
#20
Zhiqiang Hou, Xiaohan Wang, Jing Cai, Jinhui Zhang, Ahmed Hassan, Manfred Auer, Xiaorui Shi
Normal blood supply to the cochlea is critical for hearing. Noise damages auditory sensory cells and has a marked effect on the microvasculature in the cochlear lateral wall. Pericytes in the stria vascularis (strial pericytes) are particularly vulnerable and sensitive to acoustic trauma. Exposure of NG2DsRedBAC transgenic mice (6-8 weeks old) to wide-band noise at a level of 120 dB for 3 h per day for 2 consecutive days produced a significant hearing threshold shift and caused pericytes to protrude and migrate from their normal endothelial attachment sites...
August 2018: Journal of the Association for Research in Otolaryngology: JARO
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