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Journal of the Association for Research in Otolaryngology: JARO

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https://www.readbyqxmd.com/read/29464412/speech-intelligibility-predicted-from-neural-entrainment-of-the-speech-envelope
#1
Jonas Vanthornhout, Lien Decruy, Jan Wouters, Jonathan Z Simon, Tom Francart
Speech intelligibility is currently measured by scoring how well a person can identify a speech signal. The results of such behavioral measures reflect neural processing of the speech signal, but are also influenced by language processing, motivation, and memory. Very often, electrophysiological measures of hearing give insight in the neural processing of sound. However, in most methods, non-speech stimuli are used, making it hard to relate the results to behavioral measures of speech intelligibility. The use of natural running speech as a stimulus in electrophysiological measures of hearing is a paradigm shift which allows to bridge the gap between behavioral and electrophysiological measures...
February 20, 2018: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/29464411/optimal-human-passive-vestibulo-ocular-reflex-adaptation-does-not-rely-on-passive-training
#2
M Muntaseer Mahfuz, Michael C Schubert, William V C Figtree, Christopher J Todd, Serajul I Khan, Americo A Migliaccio
The vestibulo-ocular reflex (VOR) is the main vision-stabilising system during rapid head movements in humans. A visual-vestibular mismatch stimulus can be used to train or adapt the VOR response because it induces a retinal image slip error signal that drives VOR motor learning. The training context has been shown to affect VOR adaptation. We sought to determine whether active (self-generated) versus passive (externally imposed) head rotation vestibular training would differentially affect adaptation and short-term retention of the active and passive VOR responses...
February 20, 2018: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/29349595/the-development-of-a-nano-based-approach-to-alleviate-cisplatin-induced-ototoxicity
#3
Mohammad N Kayyali, Andrew J Ramsey, Elizabeth M Higbee-Dempsey, Lesan Yan, Bert W O'Malley, Andrew Tsourkas, Daqing Li
Cisplatin-induced hearing loss is experienced by a high percentage of patients with squamous cell carcinoma undergoing cisplatin chemotherapy. A novel nano-construct capable of sequestering extracellular cisplatin was developed to combat this problem. The nano-construct consisted of superparamagnetic iron oxide nanoparticles (SPIONs) entrapped within polymeric micelles, which were formed from a glutathione diethyl ester-conjugated amphiphilic diblock copolymer. The glutathione-micelles were analyzed at the cellular level and in an organotypic study for safety evaluation...
January 18, 2018: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/29318409/oncomodulin-expression-reveals-new-insights-into-the-cellular-organization-of-the-murine-utricle-striola
#4
Larry F Hoffman, Kristel R Choy, David R Sultemeier, Dwayne D Simmons
Oncomodulin (OCM, aka β-parvalbumin) is an EF-hand calcium binding protein that is expressed in a restricted set of hair cells in the peristriolar region of the mammalian utricle. In the present study, we determined the topologic distribution of OCM among hair cell phenotypes to advance our understanding of the cellular organization of the striola and the relationship of these phenotypes with characteristics of tissue polarity. The distributions of OCM-positive (OCM+) hair cells were quantified in utricles of mature C57Bl/6 mice...
January 9, 2018: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/29313147/voice-discrimination-by-adults-with-cochlear-implants-the-benefits-of-early-implantation-for-vocal-tract-length-perception
#5
Yael Zaltz, Raymond L Goldsworthy, Liat Kishon-Rabin, Laurie S Eisenberg
Cochlear implant (CI) users find it extremely difficult to discriminate between talkers, which may partially explain why they struggle to understand speech in a multi-talker environment. Recent studies, based on findings with postlingually deafened CI users, suggest that these difficulties may stem from their limited use of vocal-tract length (VTL) cues due to the degraded spectral resolution transmitted by the CI device. The aim of the present study was to assess the ability of adult CI users who had no prior acoustic experience, i...
January 8, 2018: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/29302822/robust-neuronal-discrimination-in-primary-auditory-cortex-despite-degradations-of-spectro-temporal-acoustic-details-comparison-between-guinea-pigs-with-normal-hearing-and-mild-age-related-hearing-loss
#6
Yonane Aushana, Samira Souffi, Jean-Marc Edeline, Christian Lorenzi, Chloé Huetz
This study investigated to which extent the primary auditory cortex of young normal-hearing and mild hearing-impaired aged animals is able to maintain invariant representation of critical temporal-modulation features when sounds are submitted to degradations of fine spectro-temporal acoustic details. This was achieved by recording ensemble of cortical responses to conspecific vocalizations in guinea pigs with either normal hearing or mild age-related sensorineural hearing loss. The vocalizations were degraded using a tone vocoder...
January 4, 2018: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/29299694/correction-to-aminoglycoside-damage-and-hair-cell-regeneration-in-the-chicken-utricle
#7
Mirko Scheibinger, Daniel C Ellwanger, C Eduardo Corrales, Jennifer S Stone, Stefan Heller
This article was updated to correct a formatting error in Table 1.
January 3, 2018: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/29294193/effects-of-acoustic-environment-on-tinnitus-behavior-in-sound-exposed-rats
#8
Aikeen Jones, Bradford J May
Laboratory studies often rely on a damaging sound exposure to induce tinnitus in animal models. Because the time course and ultimate success of the induction process is not known in advance, it is not unusual to maintain sound-exposed animals for months while they are periodically assessed for behavioral indications of the disorder. To demonstrate the importance of acoustic environment during this period of behavioral screening, sound-exposed rats were tested for tinnitus while housed under quiet or constant noise conditions...
January 2, 2018: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/29181615/right-ear-advantage-for-speech-in-noise-recognition-in-patients-with-nonlateralized-tinnitus-and-normal-hearing-sensitivity
#9
Yihsin Tai, Fatima T Husain
Despite having normal hearing sensitivity, patients with chronic tinnitus may experience more difficulty recognizing speech in adverse listening conditions as compared to controls. However, the association between the characteristics of tinnitus (severity and loudness) and speech recognition remains unclear. In this study, the Quick Speech-in-Noise test (QuickSIN) was conducted monaurally on 14 patients with bilateral tinnitus and 14 age- and hearing-matched adults to determine the relation between tinnitus characteristics and speech understanding...
November 27, 2017: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/29134476/aminoglycoside-damage-and-hair-cell-regeneration-in-the-chicken-utricle
#10
Mirko Scheibinger, Daniel C Ellwanger, C Eduardo Corrales, Jennifer S Stone, Stefan Heller
In this study, we present a systematic characterization of hair cell loss and regeneration in the chicken utricle in vivo. A single unilateral surgical delivery of streptomycin caused robust decline of hair cell numbers in striolar as well as extrastriolar regions, which in the striola was detected very early, 6 h post-insult. During the initial 12 h of damage response, we observed global repression of DNA replication, in contrast to the natural, mitotic hair cell production in undamaged control utricles...
November 13, 2017: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/29134475/synchronized-spontaneous-otoacoustic-emissions-provide-a-signal-to-noise-ratio-advantage-in-medial-olivocochlear-reflex-assays
#11
James D Lewis
Detection of medial olivocochlear-induced (MOC) changes to transient-evoked otoacoustic emissions (TEOAE) requires high signal-to-noise ratios (SNR). TEOAEs associated with synchronized spontaneous (SS) OAEs exhibit higher SNRs than TEOAEs in the absence of SSOAEs, potentially making the former well suited for MOC assays. Although SSOAEs may complicate interpretation of MOC-induced changes to TEOAE latency, recent work suggests SSOAEs are not a problem in non-latency-dependent MOC assays. The current work examined the potential benefit of SSOAEs in TEOAE-based assays of the MOC efferents...
November 13, 2017: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/29110135/the-effect-of-visual-contrast-on-human-vestibulo-ocular-reflex-adaptation
#12
M Muntaseer Mahfuz, Michael C Schubert, Christopher J Todd, William V C Figtree, Serajul I Khan, Americo A Migliaccio
The vestibulo-ocular reflex (VOR) is the main retinal image stabilising mechanism during rapid head movement. When the VOR does not stabilise the world or target image on the retina, retinal image slip occurs generating an error signal that drives the VOR response to increase or decrease until image slip is minimised, i.e. VOR adaptation occurs. Visual target contrast affects the human smooth pursuit and optokinetic reflex responses. We sought to determine if contrast also affected VOR adaptation. We tested 12 normal subjects, each over 16 separate sessions...
November 6, 2017: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/29086155/evaluating-multipulse-integration-as-a-neural-health-correlate-in-human-cochlear-implant-users-effects-of-stimulation-mode
#13
Ning Zhou, Lixue Dong, Mingqi Hang
Previous psychophysical studies have shown that a steep detection-threshold-versus-stimulation-rate function (multipulse integration; MPI) is associated with laterally positioned electrodes producing a broad neural excitation pattern. These findings are consistent with steep MPI depending on either a certain width of neural excitation allowing a large population of neurons operating at a low point on their dynamic range to respond to an increase in stimulation rate or a certain slope of excitation pattern that allows recruitment of neurons at the excitation periphery...
October 30, 2017: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/29047013/behavioral-animal-model-of-the-emotional-response-to-tinnitus-and-hearing-loss
#14
Amanda M Lauer, Gail Larkin, Aikeen Jones, Bradford J May
Increased prevalence of emotional distress is associated with tinnitus and hearing loss. The underlying mechanisms of the negative emotional response to tinnitus and hearing loss remain poorly understood, and it is challenging to disentangle the emotional consequences of hearing loss from those specific to tinnitus in listeners experiencing both. We addressed these questions in laboratory rats using three common rodent anxiety screening assays: elevated plus maze, open field test, and social interaction test...
October 18, 2017: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/29027038/rescue-of-outer-hair-cells-with-antisense-oligonucleotides-in-usher-mice-is-dependent-on-age-of-treatment
#15
Abhilash Ponnath, Frederic F Depreux, Francine M Jodelka, Frank Rigo, Hamilton E Farris, Michelle L Hastings, Jennifer J Lentz
The absence of functional outer hair cells is a component of several forms of hereditary hearing impairment, including Usher syndrome, the most common cause of concurrent hearing and vision loss. Antisense oligonucleotide (ASO) treatment of mice with the human Usher mutation, Ush1c c.216G>A, corrects gene expression and significantly improves hearing, as measured by auditory-evoked brainstem responses (ABRs), as well as inner and outer hair cell (IHC and OHC) bundle morphology. However, it is not clear whether the improvement in hearing achieved by ASO treatment involves the functional rescue of outer hair cells...
October 12, 2017: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/28971333/attentional-modulation-of-envelope-following-responses-at-lower-93-109%C3%A2-hz-but-not-higher-217-233%C3%A2-hz-modulation-rates
#16
Emma Holmes, David W Purcell, Robert P Carlyon, Hedwig E Gockel, Ingrid S Johnsrude
Directing attention to sounds of different frequencies allows listeners to perceive a sound of interest, like a talker, in a mixture. Whether cortically generated frequency-specific attention affects responses as low as the auditory brainstem is currently unclear. Participants attended to either a high- or low-frequency tone stream, which was presented simultaneously and tagged with different amplitude modulation (AM) rates. In a replication design, we showed that envelope-following responses (EFRs) were modulated by attention only when the stimulus AM rate was slow enough for the auditory cortex to track-and not for stimuli with faster AM rates, which are thought to reflect 'purer' brainstem sources...
October 2, 2017: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/28815315/emerging-gene-therapies-for-genetic-hearing-loss
#17
REVIEW
Hena Ahmed, Olga Shubina-Oleinik, Jeffrey R Holt
Gene therapy, or the treatment of human disease using genetic material, for inner ear dysfunction is coming of age. Recent progress in developing gene therapy treatments for genetic hearing loss has demonstrated tantalizing proof-of-principle in animal models. While successful translation of this progress into treatments for humans awaits, there is growing interest from patients, scientists, clinicians, and industry. Nonetheless, it is clear that a number of hurdles remain, and expectations for total restoration of auditory function should remain tempered until these challenges have been overcome...
October 2017: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/28755309/spatial-selectivity-in-cochlear-implants-effects-of-asymmetric-waveforms-and-development-of-a-single-point-measure
#18
Robert P Carlyon, John M Deeks, Jaime Undurraga, Olivier Macherey, Astrid van Wieringen
Three experiments studied the extent to which cochlear implant users' spatial selectivity can be manipulated using asymmetric waveforms and tested an efficient method for comparing spatial selectivity produced by different stimuli. Experiment 1 measured forward-masked psychophysical tuning curves (PTCs) for a partial tripolar (pTP) probe. Maskers were presented on bipolar pairs separated by one unused electrode; waveforms were either symmetric biphasic ("SYM") or pseudomonophasic with the short high-amplitude phase being either anodic ("PSA") or cathodic ("PSC") on the more apical electrode...
October 2017: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/28752334/erratum-to-a-modeling-study-of-the-responses-of-the-lateral-superior-olive-to-ipsilateral-sinusoidally-amplitude-modulated-tones
#19
Le Wang, H Steven Colburn
No abstract text is available yet for this article.
October 2017: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/28748487/predictions-of-speech-chimaera-intelligibility-using-auditory-nerve-mean-rate-and-spike-timing-neural-cues
#20
Michael R Wirtzfeld, Rasha A Ibrahim, Ian C Bruce
Perceptual studies of speech intelligibility have shown that slow variations of acoustic envelope (ENV) in a small set of frequency bands provides adequate information for good perceptual performance in quiet, whereas acoustic temporal fine-structure (TFS) cues play a supporting role in background noise. However, the implications for neural coding are prone to misinterpretation because the mean-rate neural representation can contain recovered ENV cues from cochlear filtering of TFS. We investigated ENV recovery and spike-time TFS coding using objective measures of simulated mean-rate and spike-timing neural representations of chimaeric speech, in which either the ENV or the TFS is replaced by another signal...
October 2017: Journal of the Association for Research in Otolaryngology: JARO
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