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Elad Arad, Ravit Malishev, Hanna Rapaport, Raz Jelinek
Assembly of fibrillar peptide structures is dependent both upon their intrinsic propensities towards β-structure formation, as well as on structural modulation by external molecular factors. β-sheet structures may either be designed to form useful assemblies or be the undesired consequence of protein denaturation to toxic amyloid structures in several neurodegenerative diseases. Membrane bilayers have been implicated as primary initiators and modulators of amyloid fibrillation and the reasons for this effect are yet to be elucidated...
December 14, 2017: Biomacromolecules
Michael H Staegemann, Susanna Gräfe, Burkhard Gitter, Katharina Achazi, Elisa Quaas, Rainer Haag, Arno Wiehe
An adaptable approach toward cleavable nanoparticle carrier systems for photodynamic therapy (PDT) is presented, comprising a biocompatible carrier loaded with multiple photosensitizer (PS) molecules related to the clinically employed PS Temoporfin, two linkers cleavable under different triggers and glyco-targeting with mannose. A synthetic pathway to stimuli responsive hyperbranched polyglycerol (hPG) porphyrin conjugates via the copper(I)-catalyzed 1,3-dipolar cycloaddition (CuAAC) or the strain-promoted alkyne-azide cycloaddition (SPAAC) has been developed...
December 12, 2017: Biomacromolecules
Maureen R Newman, Steven G Russell, Christopher S Schmitt, Ian A Marozas, Tzong-Jen Sheu, J Edward Puzas, Danielle S W Benoit
Drug delivery to bone is challenging, whereby drug distribution is commonly <1% of injected dose, despite development of several bone-targeted drug delivery systems specific to hydroxyapatite. These bone-targeted drug delivery systems still suffer from poor target cell localization within bone, as at any given time overall bone volume is far greater than acutely remodeled bone volume, which harbors relevant cell targets (osteoclasts or osteoblasts). Thus, there exists a need to target bone-acting drugs specifically to the cells responsible for bone remodeling...
December 11, 2017: Biomacromolecules
Gili Abramov, Rona Shaharabani, Omry Morag, Ram Avinery, Anat Haimovich, Inbal Oz, Roy Beck, Amir Goldbourt
No abstract text is available yet for this article.
December 11, 2017: Biomacromolecules
Sibo Guo, Hiroki Kamite, Nozomu Suzuki, Laibing Wang, Asuka Ohkubo, Michiya Fujiki
We investigated whether helicity and/or chirality of cellulose tris(phenylcarbamate) (CTPC) can transfer to non-charged, non-helical oligo- and polyfluorenes (F3, F5, F7, PF6, and PF8, Chart 1) when CTPC was employed as a solution processable homochiral platform of a D-glucose-skeletal polymer. Noticeably, CTPC revealed the solvent-driven, ambidextrous intermolecular helicity/chirality transfer capability to these fluorenes. The chiroptical inversion characteristics of circularly polarized luminescence (CPL) and the corresponding CD spectra were realized by solely choosing a proper achiral solvents and/or achiral cosolvents...
December 8, 2017: Biomacromolecules
Karolin Dietrich, Marie-Josée Dumont, Timothy Schwinghamer, Valérie Orsat, Luis F Del Rio
Softwood hemicellulose hydrolysates are a cheap source of sugars that can be used as a feedstock to produce polyhydroxybutyrates (PHB), which are biobased and compostable bacterial polyesters. To assess the potential of the hemicellulosic sugars as a carbon source for PHB production, synthetic media containing softwood hemicellulose sugars (glucose, mannose, galactose, xylose, arabinose) and the potentially inhibitory lignocellulose degradation products (acetic acid, 5-hydroxymethylfurfural (HMF), furfural, and vanillin) were fermented with the model strain Paraburkholderia sacchari IPT 101...
December 8, 2017: Biomacromolecules
Matteo Romio, Giulia Morgese, Lucca Trachsel, Samuel Babity, Cristina Paradisi, Davide Brambilla, Edmondo Maria Benetti
Functional block-copolymers based on poly(2-oxazoline)s are versatile building blocks for the fabrication of dual-drug delivery nanoparticles (NPs) that show promising properties for the development of a anticancer chemotherapy. Core-shell NPs are fabricated from diblock-copolymers featuring a long and hydrophilic poly(2-methyl-2-oxazoline) (PMOXA) block, coupled to a relatively short and functionalizable poly(2-methylsuccinate-2-oxazoline) (PMestOXA) segment. The PMOXA block stabilizes the NP dispersions, whereas the PMestOXA segment is used to conjugate pterostilbene (PTS), a natural bioactive phenolic compound that is used as lipophilic model-drug and constitutes the hydrophobic core of the designed NPs...
December 7, 2017: Biomacromolecules
Mohamad Gabriel Alameh, Marc Lavertu, Nicolas Tran-Khanh, Chi-Yuan Chang, Frédéric Lesage, Martine Bail, Vincent Darras, Anik Chevrier, Michael D Buschmann
Chitosan (CS) shows in vitro and in vivo efficacy for siRNA delivery, but with contradictory findings for incompletely characterized systems. To understand which parameters produce effective delivery, a library of precisely characterized chitosans was produced at different DDAs and Mn. Encapsulation and transfection efficiencies were characterized in vitro. Formulations were selected to examine the influence of Mn and N:P ratio on nanoparticle uptake, metabolic activity, genotoxicity, and in vitro transfection...
December 6, 2017: Biomacromolecules
Christiane Claaßen, Marc H Claaßen, Vincent Truffault, Lisa Sewald, Günter E M Tovar, Kirsten Borchers, Alexander Southan
Cross-linkable gelatin methacryloyl (GM) is widely used for the generation of artificial extracellular matrix (ECM) in tissue engineering. However, the quantification of modified groups in GM is still an unsolved issue, although this is the key factor for tailoring the physico-chemical material properties. In this contribution, 1H-13C-HSQC-NMR-spectra are used to gain detailed structural information of GMs and of two-fold modified gelatin containing methacryloyl and acetyl groups (GMAs). Distinctive identification of methacrylate, methacrylamide, and acetyl groups present in GMs and GMAs revealed an overlap of methacrylamide and modified hydroxyproline signals in the 1H-NMR spectrum...
December 6, 2017: Biomacromolecules
Yingkun Yang, Weiying Hou, Siyang Liu, Kai Sun, Minyong Li, Changfeng Wu
Conventional photodynamic therapy is severely constrained by the limited light-penetration depth in tissue. Here, we show efficient photodynamic therapy (PDT) mediated by bioluminescence resonance energy transfer (BRET) that overcomes the light-penetration limitation. A photosensitizer Rose Bengal (RB) was loaded in biodegradable poly(lactic-co-glycolic acid) (PLGA) nanoparticles, which were then conjugated with firefly luciferase. Spectroscopic characterizations indicated that BRET effectively activated RB to generate reactive oxygen species (ROS)...
December 6, 2017: Biomacromolecules
Xiaobin Huang, Yong Hou, Leilei Zhong, Dechun Huang, Hongliang Qian, Marcel Karperien, Wei Chen
We investigated the effects of different oxygen tension (21% and 2.5% O2) on the chondrogenesis of different cell systems cultured in pH-degradable PVA hydrogels including human articular chondrocytes (hACs), human mesenchymal stem cells (hMSCs) and their co-cultures with a hAC/hMSC ratio of 20/80. These hydrogels were prepared with vinyl ether acrylate-functionalized PVA (PVA-VEA) and thiolated PVA-VEA (PVA-VEA-SH) via Michael-type addition reaction. The rheology tests determined the gelation of the hydrogels was controlled within 2-7 min dependent on the polymer concentrations...
December 6, 2017: Biomacromolecules
Amanda Andersen, Marie Krogsgaard, Henrik Birkedal
Mussel-inspired hydrogels held together by reversible catecholato-metal coordination bonds have recently drawn great attention owing to their attractive self-healing, viscoelastic and adhesive properties together with their pH-responsive nature. A major challenge in these systems is to orchestrate the degree of catechol oxidation that occurs under alkaline conditions in air and has a great impact on the aforementioned properties because it introduces irreversible covalent cross-links to the system, which stiffens the hydrogels but consume catechols needed for self-healing...
December 4, 2017: Biomacromolecules
Linying Li, Nan K Li, Qing Tu, Owen Im, Chia-Kuei Mo, Wei Han, William Hayden Fuss, Nick J Carroll, Ashutosh Chilkoti, Yaroslava G Yingling, Stefan Zauscher, Gabriel P Lopez
A powerful tool for controlling interfacial properties and molecular architecture relies on the tailored adsorption of stimuli-responsive block copolymers onto surfaces. Here, we use computational and experimental approaches to investigate the adsorption behavior of thermally-responsive polypeptide block copolymers (elastin-like polypeptides, ELPs) onto silica surfaces, and to explore the effects of surface affinity and micellization on the adsorption kinetics and the resultant polypeptide layers. We demonstrate that genetic incorporation of a silica-binding peptide (silaffin R5) results in enhanced adsorption of these block copolymers onto silica surfaces as measured by quartz crystal microbalance and ellipsometry...
December 1, 2017: Biomacromolecules
Charlotte J C Edwards-Gayle, Francesca Greco, Ian W Hamley, Robert P Rambo, Mehedi Reza, Janne Ruokolainen, Dimitrios Skoulas, Hermis Iatrou
We investigate the self-assembly of two telechelic star polymer-peptide conjugates based on poly(ethylene oxide) (PEO) four-arm star polymers capped with oligotyrosine. The conjugates were prepared via N-carboxy anhydride (NCA)-mediated ring-opening polymerization from PEO star polymer macroinitiators. Self-assembly occurs above a critical aggregation concentration determined via fluorescence probe assays. Peptide conformation was examined using circular dichroism spectroscopy. The structure of self-assembled aggregates was probed using small-angle X-ray Scattering (SAXS) and cryogenic transmission electron microscopy (Cryo-TEM)...
December 1, 2017: Biomacromolecules
Sarah-Jane Richards, Klea Isulfi, Laura E Wilkins, Julia Lipecki, Elizabeth Fullam, Matthew I Gibson
Due to the emergence of antimicrobial resistance to traditional small molecule drugs, cationic antimicrobial polymers are appealing targets. Mycobacterium tuberculosis is a particular problem, with multi- and total drug resistance spreading and more than a billion latent infections globally. This study reports nanoparticles bearing variable densities of poly(dimethylaminoethyl methacrylate) and the unexpected and distinct mechanisms of action this multivalent presentation imparts against Escherichia coli verses Mycobacterium smegmatis (model of M...
December 1, 2017: Biomacromolecules
Pratyawadee Singhsa, Diana Diaz-Dussan, Hathaikarn Manuspiya, Ravin Narain
Cationic glycopolymers have shown to be excellent candidates for the fabrication of gene delivery devices due to their ability to electrostatically interact with negatively charged nucleic acids and the carbohydrate residues ensure enhanced stability and low toxicity of the polyplexes. The ability to engineer the polymers for optimized compositions, molecular weights and architectures is critical in the design of effective gene delivery vehicles. Therefore, in this study, the aqueous reversible addition-fragmentation chain transfer polymerization (RAFT) was used to synthesize well-defined cationic glycopolymers with various cationic segments...
December 1, 2017: Biomacromolecules
Daniela Cioloboc, Christopher Kennedy, Emily N Boice, Emily R Clark, Donald M Kurtz
Traditional photodynamic therapy for cancer relies on dye-photosensitized generation of singlet oxygen. However, therapeutically effective singlet oxygen generation requires well-oxygenated tissues, whereas many tumor environments tend to be hypoxic. We describe a platform for targeted enhancement of photodynamic therapy that produces singlet oxygen in oxygenated environments and hydroxyl radical, which is typically regarded as the most toxic reactive oxygen species, in hypoxic environments. The 24-subunit iron storage protein bacterioferritin (Bfr) has the unique property of binding 12 heme groups in its protein shell...
December 1, 2017: Biomacromolecules
Bailiang Wang, Huihua Liu, Lin Sun, Yingying Jin, Xiaoxu Ding, Lingli Li, Jian Ji, Hao Chen
Bacterial infections and biofilm formation on the surface of implants is an important issue which greatly affect biomedical applications and even cause device failure. Construction of high drug loading systems on the surface and control the drug release on-demand is an efficient way to lower the development of resistant bacteria and biofilm formation. In the present study, (montmorillonite/hyaluronic acid-gentamicin)10 ((MMT/HA-GS)10) organic/inorganic hybrid multilayer films were alternately self-assembled on substrates...
November 30, 2017: Biomacromolecules
Aaron Burkey, Christopher L Riley, Lyndsey K Wang, Taylor A Hatridge, Nathaniel A Lynd
The development of improved cryopreservative materials is necessary to enable complete recovery of living cells and tissue after frozen storage. Remarkably, poly(vinyl alcohol) (PVA) displays some of the same cryoprotective properties as many antifreeze proteins found in cold tolerant organisms. In particular, PVA is very effective at halting the Ostwald ripening of ice, a process that mechanically damages cells and tissue. Despite the large practical importance of such a property, the mechanism by which PVA interacts with ice is poorly understood, hindering the development of improved cryoprotective materials...
November 29, 2017: Biomacromolecules
Jun Liu, Markus Bacher, Thomas Rosenau, Stefan M Willför, Albert Mihranyan
Knowledge gaps in the biosafety data of the nanocellulose (NC) for biomedical use through various routes of administration call for closer look at health and exposure evaluation. This work evaluated the potentially immunogenic contaminants levels, e.g. endotoxin and (1,3)-β-D-glucan, in four representative NCs, i.e. wood-based NCs and bacterial cellulose (BC). The hot-water extracts were analysed with ELISA assays, HPSEC-MALLS, GC, and NMR analysis. Varying levels of endotoxin and (1,3)-β-D-glucan contaminats were found in these widely used NCs...
November 28, 2017: Biomacromolecules
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