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Libo Zhang, Yanmei Xu, Thomas M Makris, Qian Wang
A novel N-oxygenase coated core-shell nanoparticle was generated through the co-assembly of poly(4-vinylpyridine) (P4VP) and arylamine N-oxygenase CmlI. The resulting enzyme-hybridized particles, P4VP-CmlI, showed excellent catalytic activities on the oxidation of two arylamine substrates, i.e. p-aminophenol (pAP) and p-aminobenzoic acid (pABA), using a surrogate redox system or a peroxide shunt as co-oxidants. In comparison to the free enzyme, P4VP-CmlI particles exhibited a significantly enhanced catalytic efficiency when using pyridine nucleotide (NADH) and proper redox mediators...
February 20, 2018: Biomacromolecules
Bin Du, Shaona Jia, Qinghui Wang, Xiaoyu Ding, Ying Liu, Hanchun Yao, Jie Zhou
In this study, an intelligent pH and ROS dual-responsive drug delivery system based on apoferritin (AFt) nanocage was prepared. This therapeutic system can specifically self-targeting to 4T1 breast cancer cells by exploiting L-apoferritin receptor SCARA 5, avoiding the nonspecific binding or aggregation of nanoparticles due to the chemical functionalization for targeting. The characteristics of AFt were utilized for the simultaneous delivery of anticancer drug doxorubicin (DOX) and photosensitizer rose bengal (RB)...
February 17, 2018: Biomacromolecules
Sujit Kootala, Luimar Filho, Vaibhav Srivastava, Victoria Linderberg, Amani Moussa, Laurent David, Stéphane Trombotto, Thomas Crouzier
The mucus gel covers the wet epithelia that forms the inner lining of the body. It constitutes our first line of defense protecting the body from infections and other deleterious molecules. Failure of the mucus barrier can lead to the inflammation of the mucosa such as in inflammatory bowel diseases. Unfortunately, there are no effective strategies that reinforce the mucus barrier properties to recover or enhance its ability to protect the epithelium. Herein, we describe a mucus engineering approach that addresses this issue where we physically crosslink the mucus gel with low molar mass chitosan variants to reinforce its barrier functions...
February 16, 2018: Biomacromolecules
Anuradha Gupta, Anas Ahmad, Hardeep Singh, Sharanjeet Kaur, Neethu K M, Md Meraj Ansari, Govindasamy Jayamurugan, Rehan Khan
Synthetic lethality is a molecular targeted therapy for selective killing of cancer cells. We exploited a lethal interaction between Superoxide dismutase1 inhibition and Bloom syndrome gene product (BLM) defect for the treatment of colorectal cancer (CRC) cells (HCT 116) with lung cancer screen-1 (LCS-1) loaded customized nanocarrier. LCS-1 has poor aqueous solubility. To overcome its limitations, customized nanocarrier (NC), composed of magnetite core coated with three polymeric shells namely, aminocellulose, branched poly(amidoamine) and paraben-PEG, was developed for encapsulating LCS-1...
February 16, 2018: Biomacromolecules
Anasua Mukhopadhayay, Tarasankar Das, Anindya Datta, Kamendra P Sharma
Solvents particularly those having low-volatility are of great interest for the biocatalytic synthesis of utility chemicals and fuels. Here we show novel and universal solvent-like properties of a neat and water-less polymer surfactant-BSA conjugated material (WL-PSpBSA). This highly viscous, non-volatile material, behaves as a liquid above its solid-liquid transition temperature (≈ 25-27 °C), and can be used as a solvent for variety of completely dry solutes of different sizes, and surface chemistries. We show using a combination of optical microscopy, steady state and time-resolved fluoresence spectroscopy, that dry and powdered dyes (hydrophobic Coumarin 153; C153), enzymes (α-chymotrypsin; α-Chy), or even 2 μm microparticles (diffusion coefficient ca...
February 16, 2018: Biomacromolecules
Zhuo Zhang, Xiaolin Wang, Yitong Wang, Jingcheng Hao
To meet the progressive requirements of advanced engineering materials with superior physicochemical performances, self-healing and injectable hydrogels (AD hydrogels) based on agarose with pH-response were prepared through dynamic covalent Schiff-base linkages by simply mixing nontoxic agarose-ethylenediamine conjugate (AG-NH2) and dialdehyde-functionalized polyethylene glycol (DF-PEG) solutions. The self-healing and injectable capabilities of the hydrogels without any external stimulus are ascribed to dynamic covalent Schiff-base linkages between the aldehyde groups of DF-PEG and amine groups on AG-NH2 backbone...
February 16, 2018: Biomacromolecules
Keith H Parsons, Mosharrof H Mondal, Charles L McCormick, Alex S Flynt
RNAi-based technologies are ideal for pest control as they can provide species specificity and spare non-target organisms. However, in some pests biological barriers prevent use of RNAi, and therefore broad application. In this study we tested the ability of a synthetic cationic polymer, poly-[N-(3-guanidinopropyl)methacrylamide] (pGPMA), that mimics arginine-rich cell penetrating peptides to trigger RNAi in an insensitive animal-Spodoptera frugiperda. Polymer-dsRNA interpolyelectrolyte complexes (IPECs) were found to be efficiently taken up by cells, and to drive highly efficient gene knockdown...
February 15, 2018: Biomacromolecules
Xue-Jian Zhang, Xiao-Wei Wang, Xiao-Di Da, Yanlin Shi, Chunli Liu, Fei Sun, Shuguang Yang, Wen-Bin Zhang
Protein-based materials call for innovative processing techniques to integrate their unique biologically enabled functions with other materials of complementary features. Herein, we report the covalent protein layer-by-layer assembly via orthogonal "Tag-Catcher" reactions as a facile and robust approach to make entirely protein-based multilayers on a variety of substrates. Programmed assembly of native telechelic proteins not only endows the materials valuable stimuli-sensitive behaviors, but also unique properties unparalleled by any synthetic counterparts...
February 14, 2018: Biomacromolecules
Laura J Smith, S Maryamdokht Taimoory, Roger Y Tam, Alexander E G Baker, Niema Binth Mohammad, John F Trant, Molly S Shoichet
Engineered hydrogels have been extensively used to direct cell function in 3D cell culture models, which are more representative of the native cellular microenvironment than conventional 2D cell culture. Previously, hyaluronan-furan and bis-maleimide polyethylene glycol hydrogels were synthesized via Diels-Alder chemistry at acidic pH, which did not allow encapsulation of viable cells. In order to enable gelation at physiological pH, the reaction kinetics were accelerated by replacing the hyaluronan-furan with the more electron-rich hyaluronan-methylfuran...
February 14, 2018: Biomacromolecules
Lindsey A Sharpe, Julia E Vela Ramirez, Olivia M Haddadin, Kathleen A Ross, Balaji Narasimhan, Nicholas A Peppas
Multi-compartmental polymer carriers, referred to as Polyanhydride-Releasing Oral MicroParticle Technology (PROMPT), were formed by a pH-triggered anti-solvent precipitation technique. Polyanhydride nanoparticles were encapsulated into anionic pH-responsive microparticles, allowing for nanoparticle encapsulation in acidic conditions and subsequent release in neutral pH conditions. The effects of varying the nanoparticle composition and feed ratio on the encapsulation efficiency were evaluated. Nanoparticle encapsulation was confirmed by confocal microscopy and infrared spectroscopy...
February 14, 2018: Biomacromolecules
Myriam Hayder, Matteo Garzoni, Davide Bochicchio, Anne-Marie Caminade, François Couderc, Varravaddheay Ong-Meang, Jean-Luc Davignon, Cédric-Olivier Turrin, Giovanni M Pavan, Remy Poupot
Dendrimers are nanosized, non-linear, hyperbranched polymers whose overall three-dimensional shape is key for their biological activity. Poly(PhosphorHydrazone) (PPH) dendrimers capped with aza-bisphosphonate (ABP) end groups are known to have anti-inflammatory properties enabling the control of inflammatory diseases in different mouse models. Here we screen the anti-inflammatory activity of a series of PPH bearing between 2 and 16 ABP end groups in a mouse model of arthritis, and confront the biological results with atomistic simulations of the dendrimers...
February 14, 2018: Biomacromolecules
Arushi Prakash, Marcel D Baer, Christopher J Mundy, Jim Pfaendtner
Peptoids are peptide-mimetic biopolymers that are easy-to-synthesize and adaptable for use in drugs, chemical scaffolds, and coatings. However, there is insufficient information about their structural preferences and interactions with the environment in various applications. We conducted a study to understand the fundamental differences between peptides and peptoids using molecular dynamics simulations with semi-empirical (PM6) and empirical (AMBER) potentials, in conjunction with metadynamics enhanced sampling...
February 14, 2018: Biomacromolecules
Siqi Huan, Guoxiang Liu, Guangping Han, Long Bai
Uniform PLA/CNC nanofibrous mats composed of either random or aligned fibers reinforced with up to 20 wt% cellulose nanocrystals (CNCs) were successfully produced by two different electrospinning processes. Various concentrations of CNCs could be stably dispersed in PLA solution prior to nanofiber manufacture. The microstructure of produced fibrous mats, regardless of random or aligned orientation, was transformed from smooth to nanoporous surface by changing CNC loading levels. Aligning process through secondary stretching during high-speed collecting can also affect the porous structure of fibers...
February 14, 2018: Biomacromolecules
Nejla B Erdal, Minna Hakkarainen
Bioactive and reinforced poly(ε-caprolactone) (PCL) films were constructed by incorporation of cellulose derived reduced nano-graphene oxide (r-nGO) carbon nanodots. Two different microwave-assisted reduction routes in superheated water were utilized to obtain r-nGO and r-nGO-CA. For the latter a green reducing agent, caffeic acid (CA) was incorporated in the reduction process. The materials were extruded and compression molded to obtain proper dispersion of the carbon nanodots in the polymer matrix. FTIR results revealed favorable interactions between r-nGO-CA and PCL that improved the dispersion of r-nGO-CA...
February 13, 2018: Biomacromolecules
Charmainne Cruje, Joy Dunmore-Buyze, Jarret P MacDonald, David W Holdsworth, Maria Drangova, Elizabeth R Gillies
Despite recent technological advancements in microcomputed tomography (micro-CT) and contrast agent development, pre-clinical contrast agents are still predominantly iodine-based. Higher contrast can be achieved when using elements with higher atomic numbers, such as lanthanides; lanthanides also have x-ray attenuation properties that are ideal for spectral CT. However, the formulation of lanthanide-based contrast agents at the high concentrations required for vascular imaging presents a significant challenge...
February 13, 2018: Biomacromolecules
Yue Tao, Shixue Wang, Xiaojie Zhang, Zhen Wang, Youhua Tao, Xianhong Wang
Alternating polypeptoids are particularly appealing because alternating sequence may impart highly-ordered structure and special functions, while their simple synthesis still remains a key challenge. Herein, we describe that natural amino acid monomers can be polymerized via Ugi reaction in a step-growth fashion as an AA' BB' system, which leads to alternating polypeptoids with molecular weight up to 15 kg/mol. These alternating polypeptoids are thermally responsive and exhibit cloud points (Tcps) between 27 and 37 oC...
February 13, 2018: Biomacromolecules
Hadi Hezaveh, Steffen Cosson, Ellen A Otte, Guannan Su, Benjamin D Fairbanks, Justin J Cooper-White
Capturing cell-secreted extracellular matrix (ECM) proteins through cooperative binding with high specificity and affinity is an important function of native tissue matrices during both tissue homeostasis and repair. However, whilst synthetic hydrogels, such as those based on polyethylene glycol (PEG), are often proposed as ideal materials to deliver human mesenchymal stem cells (hMSCs) to sites of injury to enable tissue repair, they do not have this capability, a capability that would enable cells to actively remodel their local extracellular microenvironment and potentially provide the required feedback control for more effective tissue genesis...
February 13, 2018: Biomacromolecules
Nikunjkumar R Visaveliya, J Michael Köhler
Controlling shapes of polymer nanoparticles via single-step process is a challenge due to their amorphous chemical nature. Precise regulation of interfacial interactions, electrical charging and reaction dynamics during ongoing polymerization process provides an environment where uniform nucleation, growth and in-situ assembling can be realized, and hence nanoparticles of complex shapes can be obtained. In this work, it is investigated how in-situ assembling of the growing nanoparticles succeeds and specifically in different manners by using cationic, anionic, poly-ionic, and non-ionic surface-active agents in a time-dependent blended form...
February 12, 2018: Biomacromolecules
Xinyuan Xu, Dongyue Zhang, Shangwei Gao, Toshikazu Shiba, Quan Yuan, Kai Cheng, Hong Tan, Jianshu Li
Current implant materials have widespread clinical applications together with some disadvantages, the majority of which are easily to induce infection and hardly to exhibit biocompatibility. To efficiently improve their properties, the development of interface multifunctional modification in a simple, universal and environment benign approach becomes a critical challenge and appeals numerous attention of scientists. In this study, a lysozyme-polyphosphate composite coating was fabricated for titanium(Ti)-based biomaterial in order to obtain multifunctional surface...
February 12, 2018: Biomacromolecules
Ding Qu, Lixiang Wang, Meng Liu, Shiyang Shen, Teng Li, Yuping Liu, Mengmeng Huang, Congyan Liu, Yan Chen, Ran Mo
No abstract text is available yet for this article.
February 12, 2018: Biomacromolecules
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