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Susana Torron, Stefan Semlitsch, Mats Martinelle, Mats Johansson
The work herein presented describes the synthesis and polymerization of series of biobased epoxy resins prepared through lipase catalyzed transesterification. The epoxy-functional polyester resins with various architectures (linear, tri-branched and tetra-branched) were synthesized through condensation of fatty acids derived from epoxidized soybean oil and linseed oil with 3 different hydroxyl cores under bulk conditions. The selectivity of the lipases towards esterification/ transesterification reactions allowed the formation of macromers with up to 12 epoxides in the backbone...
November 3, 2016: Biomacromolecules
Takashi Hoshiba, Eri Nemoto, Kazuhiro Sato, Hiroka Maruyama, Chiho Endo, Masaru Tanaka
Stem cell differentiation is an important issue in regenerative medicine and tissue engineering. It has been reported that cell shape is one of the factors that determine the lineage commitment of mesenchymal stem cells (MSCs). Therefore, the substrates have been developed to control their shapes. Recently, we found that poly(2-methoxyethyl acrylate) (PMEA) analogs can control tumor cell shape through the alteration of protein adsorption. Here, the adipogenesis of an adipocyte-progenitor cell, 3T3-L1 cells, was attempted; adipogenesis was to be regulated by surfaces coated with PMEA analogs through the control of their shape...
November 3, 2016: Biomacromolecules
Irawan Pramudya, Catalina Gomez Rico, Choogon Lee, Hoyong Chung
A new terpolymer adhesive, poly(2-methoxyethyl acrylate-co-N-methacryloyl 3,4-dihydroxyl-L-phenylalanine-co-heptaisobutyl substituted polyhedral oligomeric silsesquioxane propylmethacrylate) (poly(MEA-co-MDOPA-co-MPOSS) was synthesized by thermally initiated radical polymerization. In this study, we investigated the effect of the POSS component on adhesion, mechanical, and optical properties of the catechol-group containing bioinspired adhesives. The terpolymer contains the catechol group which is known to improve the adhesion properties of polymers...
November 1, 2016: Biomacromolecules
Adel Dalilottojari, Bahman Delalat, Frances J Harding, Michaelia P Cockshell, Claudine S Bonder, Nicolas H Voelcker
Porous silicon (pSi) substrates are a promising platform for cell expansion, since pore size and chemistry can be tuned to control cell behavior. In addition, a variety of bioactives can be loaded into the pores and subsequently released to act on cells adherent to the substrate. Here, we construct a cell microarray on a plasma polymer coated pSi substrate that enables the simultaneous culture of human endothelial cells on printed immobilized protein factors, while a second soluble growth factor is released from the same substrate...
November 1, 2016: Biomacromolecules
Yiping Cao, Shugang Li, Yapeng Fang, Katsuyoshi Nishinari, Glyn O Phillips
Conformation and conformational transitions are essential for the biological and technological functions of natural polyelectrolytes, e.g., DNA. This study aims to clarify how the conformational transition of natural polyelectrolyte is affected and tuned by electrostatic complexation with protein as encountered in many biological processes. A model protein/polyelectrolyte system, β-lactoglobulin (β-lg) and κ-carrageenan (κ-car), was used for the investigation. The effect was found to be determined by the molecular state of β-lg/κ-car electrostatic complexation and the molecular weight of protein...
October 28, 2016: Biomacromolecules
Yihua Liu, Haruka Oda, Yuuki Inoue, Kazuhiko Ishihara
Quantum dots (QDs) were functionalized with well-defined polymer chains having both cytocompatibility and pH-responsiveness to monitor the movement of nanoparticles in a cellular environment with changing local pH. We used a triblock-type water-soluble polymer composed of three segments: (1) pH-responsive poly[2-(N, N-diethylamino)ethyl methacrylate; DEAEMA] segment, (2) poly[ω-(p-nitrophenyloxycarbonyl oligo(ethylene glycol)) methacrylate; MEONP] segment bearing an active ester group to react with an amino compound, and (3) cytocompatible poly[(2-methacryloyloxyethyl phosphorylcholine; MPC) segment...
October 28, 2016: Biomacromolecules
Reidar Lund, JooChuan Ang, Jessica Y Shu, Ting Xu
Coiled-coil peptide-polymer conjugates are an emerging class of biomaterials. Fundamental understanding of the coiled-coil oligomeric state and assembly process of these hybrid building blocks is necessary to exert control over their assembly into well-defined structures. Here, we studied the effect of peptide structure and PEGylation on the self-assembly process and oligomeric state of a Langmuir monolayer of amphiphilic coiled-coil peptide-polymer conjugates using x-ray reflectivity (XR) and grazing-incidence x-ray diffraction (GIXD)...
October 26, 2016: Biomacromolecules
Svenja Winzen, James Ciro Schwabacher, Julius Mueller, Katharina Landfester, Kristin Mohr
Surfactants, even in miniscule amounts, are often used for the synthesis and especially the stabilization of nanomaterials, which is essential for in vivo applications. In this study, we show that the interaction between nanoparticles and proteins strongly depends on the type of stabilizing surfactants and their (small) concentration changes. The reaction between human serum albumin (HSA) and polystyrene nanoparticles (PS-NPs) stabilized by an ionic or nonionic surfactant - sodium dodecyl sulfate (SDS) or Lutensol AT50, respectively - was monitored using isothermal titration calorimetry (ITC)...
October 26, 2016: Biomacromolecules
Peter Olsén, Jenny Undin, Karin Odelius, Helmut Keul, Ann-Christine Albertsson
Full control over the ceiling temperature (Tc) enables a selective transition between the monomeric and polymeric state. This is exemplified by the conversion of the monomer 2-allyloxymethyl-2-ethyl-trimethylene carbonate (AOMEC) to poly(AOMEC) and back to AOMEC within 10 h by controlling the reaction from conditions that favor ring-opening polymerization (Tc > T0) (where T0 is the reaction temperature) to conditions that favor ring-closing depolymerization (Tc < T0). The ring-closing depolymerization (RCDP) mirrors the polymerization behavior, with a clear relation between the monomer concentration and the molecular weight of the polymer, indicating that RCDP occurs at the chain end...
October 26, 2016: Biomacromolecules
Xia Song, Yuting Wen, Jing-Ling Zhu, Feng Zhao, Zhongxing Zhang, Jun Li
Paclitaxel (PTX), a hydrophobic anticancer drug, is facing several clinical limitations such as low bioavailability and drug resistance. To solve the problems, a well-defined b-cyclodextrin-poly(N-isopropylacrylamide) star polymer was synthesized and used as a nanocarrier to improve the water solubility and aim to thermoresponsive delivery of PTX to cancer cells. The star polymer was able to form supramolecular self-assembled inclusion complex with PTX via host-guest interaction at room temperature, which is below the low critical solution temperature (LCST) of the star polymer, significantly improving the solubilization of PTX...
October 24, 2016: Biomacromolecules
Kaixuan Ren, Haitao Cui, Qinghua Xu, Chaoliang He, Gao Li, Xuesi Chen
Bone marrow-derived mesenchymal stem cells (BMSCs) possess vast potential for tissue engineering and regenerative medicine. In this study, an injectable hydrogel comprising poly(L-glutamic acid)-graft-tyramine (PLG-g-TA) with tunable microenvironment was developed via enzyme-catalyzed crosslinking, and used as artificial extracellular matrix (ECM) to explore the behaviors of BMSCs during three dimensional (3D) culture. It was found that the mechanical property, porous structure as well as degradation process of the hydrogels could be tuned by changing the copolymer concentration...
October 24, 2016: Biomacromolecules
Hyemin Kim, Won Ho Kong, Keum-Yong Seong, Dong Kyung Sung, Hyeonseon Jeong, Jin Kon Kim, Seung Yun Yang, Sei Kwang Hahn
Epidermal growth factor (EGF) has been recognized as an excellent wound healing agent due to its therapeutic function stimulating skin cell growth, proliferation and differentiation. However, the transdermal delivery of EGF poses a significant challenge due to its short half-life and lack of efficient formulation. Here, to improve the transdermal delivery efficiency, EGF was conjugated to hyaluronate (HA), which was formulated into a patch-type film for skin wound healing. HA-EGF conjugate was synthesized by coupling reaction between aldehyde-modified HA and N-terminal amine group of EGF to minimize the loss of biological activities...
October 24, 2016: Biomacromolecules
Niloofar Eslahi, Marjan Abdorahim, Abdolreza Arash Simchi
Stimuli responsive hydrogels (SRHs) are attractive bio-scaffolds for tissue engineering. The structural similarity of SRHs to the extracellular matrix (ECM) of many tissues offers great advantages for a minimally invasive tissue repair. Among various potential applications of SRHs, cartilage regeneration has attracted significant attention. The repair of cartilage damage is challenging in orthopedics owing to its low repair capacity. Recent advances include development of injectable hydrogels to minimize invasive surgery with nanostructured features and rapid stimuli-responsive characteristics...
October 24, 2016: Biomacromolecules
Maarten A Mees, Christiane Effenberg, Dietmar Appelhans, Richard Hoogenboom
Carbohydrates are important in signaling, energy storage and metabolism. Depending on their function, carbohydrates can be part of larger structures, such as glycoproteins, glycolipids or other functionalities (glycoside). To this end, polymers can act as carriers of carbohydrates in so-called glycopolymers, which mimic the multivalent carbohydrate functionalities. We chose a biocompatible poly(2-ethyl-2-oxazoline) (PEtOx) as the basis for making glycopolymers. Via the partial hydrolysis of PEtOx, a copolymer of PEtOx and polyethyleneimine (PEI) was obtained; the subsequent reductive amination with the linear forms of glucose and maltose yielded the glycopolymers...
October 21, 2016: Biomacromolecules
Natalia Eliza Domeradzka, Marc W T Werten, Frits A de Wolf, Renko de Vries
Previously, we developed triblock protein polymers that form fibrillar hydrogels at low protein polymer concentrations (denoted C2-SH48-C2). We here demonstrate that the structure of these hydrogels can be tuned via heterodimeric coiled coils that cross-link and bundle the self-assembled protein-polymer fibrils. We fused well-characterized, 47 amino acids-long heterodimeric coiled coil "linkers" (DA or DB) to the C-terminus of the triblock polymer. The resulting C2-SH48-C2-DA and C2-SH48-C2-DB polymers, were successfully produced as secreted proteins in Pichia pastoris, with titers of purified protein in the order of g L-1 of clarified broth...
October 21, 2016: Biomacromolecules
Erfan Dashtimoghadam, Ghasem Bahlakeh, Hamed Salimi-Kenari, Mohammad Mahdi Hasani-Sadrabadi, Hamid Mirzadeh, Bo Nyström
The temperature-induced gelation of chitosan/glycerophosphate (Chs/GP) systems through physical interactions has shown great potential for various biomedical applications. In the present work, hydroxyethyl cellulose (HEC) was added to the thermosensitive Chs/GP solution to improve the mechanical strength and gel properties of the incipient Chs/HEC/GP gel in comparison with the Chs/GP hydrogel at body temperature. The physical features of the macromolecular complexes formed by the synergistic interaction between chitosan and hydroxyethyl cellulose in the presence of β-glycerophosphate disodium salt solution have been studied essentially from a rheological point of view...
October 21, 2016: Biomacromolecules
Rajesh A Shenoi, Srinivas Abbina, Jayachandran N Kizhakkedathu
Understanding the influence of degradable chemical moieties on in vivo degradation, tissue distribution and excretion is critical for the design of novel biodegradable drug carriers. Polyketals have recently emerged as a promising therapeutic delivery platform due to their ability to degrade under mild acidic intracellular compartments and generation of non-toxic degradation products. However, the effect of chemical structure of the ketal groups on the in vivo degradation, biodistribution and pharmacokinetics of water soluble ketal-containing polymers has not been explored...
October 17, 2016: Biomacromolecules
Yang Wang, Ting Li, Xuefei Wang, Piming Ma, Huiyu Bai, Weifu Dong, Yi Xie, Mingqing Chen
Melanin, a kind of well-known multifunctional biomacromolecules that are widely available in large quantities from a variety of natural sources. In this work, Polyurethane (PU) /melanin nanocomposites with enhanced tensile strength and toughness were successfully fabricated via in situ polymerization. It was found that the tensile strength (σ), elongation-at-break (εmax) and work to fracture (W) were increased from 5.6 MPa, 770% and 33 MJ/m3 for PU to 51.5 MPa, 1880% and 413 MJ/m3 for PU/melanin (2 wt %) nanocomposite, respectively...
October 17, 2016: Biomacromolecules
Alexander K Andrianov, Alexander Marin, Thomas R Fuerst
Two macromolecular immunoadjuvants - poly[di(carboxylatophenoxy)phosphazene], PCPP and poly[di(carboxylatoethylphenoxy)phosphazene], PCEP have been investigated for their molecular interactions with model and bio-pharmaceutically important proteins in solutions, as well as for their TLR stimulatory effects and pH-dependent membrane disruptive activity in cellular assays. Solution interactions between polyphosphazenes and proteins, including antigens and soluble immune receptor proteins, have been studied using Asymmetric Flow Field Flow Fractionation (AF4) and Dynamic Light Scattering (DLS) at near physiological conditions - phosphate buffered saline, pH 7...
October 17, 2016: Biomacromolecules
Hao-Ching Hsiao, Andres Santos, David W Howell, Jan L Patterson, Robin S L Fuchs-Young, Sarah E Bondos
Tumorigenic cell behaviors can be suppressed or enhanced by their physicochemical environment. As a first step toward developing materials that allow tumorigenic behaviors to be observed and manipulated, we cultured related MCF10 breast cell lines on fibers composed of the Drosophila protein Ultrabithorax (Ubx). These cell lines, originally derived from fibrocystic breast tissue, represent a continuum of tumorigenic behavior. Immortal but nontumorigenic MCF10A cells, as well as semitumorigenic MCF10AT cells, attached and spread on Ubx fibers...
October 17, 2016: Biomacromolecules
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