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Biomacromolecules

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https://www.readbyqxmd.com/read/28776978/multilayered-polysaccharide-nanofilms-for-controlled-delivery-of-pentoxifylline-and-possible-treatment-of-chronic-venous-ulceration
#1
Jan Stana, Janja Stergar, Lidija Gradišnik, Vojko Flis, Rupert Kargl, Eleonore Fröhlich, Karin Stana Kleinschek, Tamilselvan Mohan, Uroš Maver
Local drug delivery systems made from nontoxic polysaccharide nanofilms have an enormous potential in wound care. A detailed understanding of the structural, surface, physicochemical, and cytotoxic properties of such systems is crucial to design clinically efficacious materials. Herein, we fabricated polysaccharide-based nanofilms onto either a 2D model (SiO2 and Au sensors) or on nonwoven alginate 3D substrates using an alternating assembly of N,N,N-trimethylchitosan (TMC) and alginic acid (ALG) by a spin-assisted layer-by-layer (LbL) technique...
August 22, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28825470/self-assembled-peptide-carbon-nitride-hydrogel-as-a-light-responsive-scaffold-material
#2
Jong Wan Ko, Woo Seok Choi, Jinhyun Kim, Su Keun Kuk, Sahng Ha Lee, Chan Beum Park
Peptide self-assembly is a facile route to the development of bioorganic hybrid materials that have sophisticated nanostructures towards diverse applications. Here, we report the synthesis of self-assembled peptide (Fmoc-diphenylalanine, Fmoc-FF)/graphitic carbon nitride (g-C3N4) hydrogels for light harvesting and biomimetic photosynthesis through non-covalent interactions between aromatic rings in Fmoc-FF nanofibers and tris-s-triazine in g-C3N4 nanosheets. According to our analysis, the photocurrent density of the Fmoc-FF/g-C3N4 hydrogel was 1...
August 21, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28820944/exploration-of-macroporous-polymeric-sponges-as-drug-carriers
#3
Gaigai Duan, Amir R Reza Bagheri, Shaohua Jiang, Jacob Golenser, Seema Agarwal, Andreas Greiner
Achieving high drug loading capacity and controlling drug delivery are two main challenges related to drug carriers. In this study, polymeric macroporous sponges with very high pore volume and large porosity are introduced as a new-type of drug carrier. Due to the high pore volume (285 and 166 cm3/g for the sponges with densities of 3.5 and 6.0 mg/cm3, respectively), the sponges exhibit very high drug loading capacities with average values of 1870 ± 114 and 2697 ± 73 mg/g in the present study, which is much higher than the meso and microporous drug carriers (< 1500 mg/g)...
August 18, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28820580/enhanced-fluorescence-emission-and-singlet-oxygen-generation-of-photosensitizers-embedded-in-injectable-hydrogels-for-imaging-guided-photodynamic-cancer-therapy
#4
Liu-Yuan Xia, Xiaodong Zhang, Meng Cao, Zhan Chen, Fu-Gen Wu
Benefiting from their inherent localized and controlled release properties, hydrogels are ideal delivery systems for therapeutic drugs or nanoparticles. In particular, the applications of hydrogels for the delivery and release of photo-responsive drugs or nanoparticles are receiving increasing attention. However, the effect of the hydrogel matrix on the fluorescence emission and singlet oxygen generation efficiency of the embedded photosensitizers (PSs) has not been clarified. Herein, meso-tetrakis (1-methylpyridinium-4-yl) porphyrin (TMPyP) as a water-soluble PS is encapsulated into an injectable hydrogel formed by glycol chitosan and dibenzaldehyde-terminated telechelic poly(ethylene glycol)...
August 18, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28817771/ice-templated-and-cross-linked-amyloid-fibril-aerogel-scaffolds-for-cell-growth
#5
Gustav Nyström, Wye-Khay Fong, Raffaele Mezzenga
Amyloid fibrils prepared from β-lactoglobulin were used to form freeze-dried and cross-linked aerogels. By varying the fibril concentration and freezing gradient, it was possible to control the pore structure and elastic modulus of the aerogels over one order of magnitude from ~2 to ~200 kPa. Using butane tetracarboxylic acid as cross-linker these aerogels maintained their monolithic shape in aqueous conditions displaying elastic behavior and a modulus in the range of 4-40 kPa. When explored as scaffolds for cell growth, the amyloid fibril aerogels demonstrated biocompatibility and led to the successful penetration and permeation of two epithelial cell lines (Caco-2 and HT29) throughout the scaffold...
August 17, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28817259/sub-20-nm-stable-micelles-based-on-a-mixture-of-coiled-coils-a-platform-for-controlled-ligand-presentation
#6
JooChuan Ang, Dan Ma, Benson Thomas Jung, Sinan Keten, Ting Xu
Ligand-functionalized, multivalent nanoparticles have been extensively studied for biomedical applications from imaging agents to drug delivery vehicles. However, the ligand cluster size is usually heterogeneous and the local valency is ill-defined. Here, we present a mixed micelle platform hierarchically self-assembled from a mixture of two amphiphilic 3-helix and 4-helix peptide-PEG-lipid hybrid conjugates. We demonstrate that the local multivalent ligand cluster size on the micelle surface can be controlled based on the coiled-coil oligomeric state...
August 17, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28816438/interfacial-mechanisms-of-water-vapor-sorption-into-cellulose-nanofibril-films-as-revealed-by-quantitative-models
#7
Minna Hakalahti, Marco Faustini, Cédric Boissière, Eero Kontturi, Tekla Tammelin
Humidity is an efficient instrument for facilitating changes in local architectures of 2-dimensional surfaces assembled from nanoscaled biomaterials. Here, complementary surface-sensitive methods are used to collect explicit and precise experimental evidence on the water vapor sorption into (2,2,6,6-tetramethylpiperidin-1-yl)oxyl (TEMPO) oxidized cellulose nanofibril (CNF) thin film over the relative humidity (RH) range from 0 to 97%. Changes in thickness and mass of the film due to water vapor uptake are tracked using Spectroscopic Ellipsometry and Quartz Crystal Microbalance with Dissipation monitoring, respectively...
August 17, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28813139/tunable-injectable-hydrogels-based-on-peptide-crosslinked-cyclized-polymer-nanoparticles-for-neural-progenitor-cell-delivery
#8
Tianyu Zhao, Drew L Sellers, Yilong Cheng, Philip J Horner, Suzie H Pun
A PEG-based cyclized vinyl polymer was synthesized via one-step RAFT polymerization and used as a precursor of injectable hydrogels. Dithiol linkers including laminin-derived peptides containing IKVAV and YIGSR sequences and DTT were used for gelation. Fast and adjustable gelation rate was achieved through nucleophile-initiated thiol-Michael reaction under physiological conditions. Low swelling ratio and moderate degradation rate of the formed hydrogels were observed. 3D encapsulation of neural progenitor cells in the synthetic hydrogel showed good cell viability over 8 days...
August 16, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28813136/targeting-of-cellular-organelles-by-fluorescent-plasmid-dna-nanoparticles
#9
Diana Costa, Carolina Costa, Margarida Vaz Caldeira, Luisa Maria Cortes, João A Queiroz, Carla Cruz
The development of a suitable delivery system and the targeting of intracellular organelles are both essential for the success of drug and gene therapies. The conception of fluorescent ligands, displaying targeting specificity together with low toxicity, is an emerging and reliable tool to develop innovative delivery systems. Biocompatible BSA or pDNA/ligand nanoparticles were synthesized by a co-precipitation method and were shown to display adequate sizes and morphology for delivery purposes, and positive surface charges...
August 16, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28774173/ph-responsive-poly-ethylene-glycol-block-polylactide-micelles-for-tumor-targeted-drug-delivery
#10
Lin Xiao, Lixia Huang, Firmin Moingeon, Mario Gauthier, Guang Yang
A biodegradable micellar drug delivery system with a pH-responsive sheddable PEG shell was developed using an acetal-linked poly(ethylene glycol)-block-polylactide (PEG-a-PLA) copolymer and applied to the tumoral release of paclitaxel (PTX). The micelles with a diameter of ∼100 nm were stable in PBS at pH 7.4, started shedding the shell and aggregating slowly at pH 6.5, and decomposed faster at pH 5.5. PTX-loaded micelles (M-PTX) with a drug loading of 6.9 wt % exhibited pH-triggered PTX release in simulated tumoral acidic environments corresponding to the extracellular and intracellular spaces...
August 16, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28809539/polymersomes-with-endosomal-ph-induced-vesicle-to-micelle-morphology-transition-and-a-potential-application-for-controlled-doxorubicin-delivery
#11
Turgay Yildirim, Anja Traeger, Pelin Sungur, Stephanie Hoeppener, Carolin Kellner, Ilknur Yildirim, David Pretzel, Stephanie Schubert, Ulrich S Schubert
A series of pH responsive block copolymers were synthesized via the reversible addition-fragmentation chain transfer (RAFT) polymerization of 3,4-dihydro-2H-pyran (DHP) protected 2-hydroxyethyl methacrylate (HEMA) (2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl methacrylate (THP-HEMA)) and 2-(dimethylamino) ethyl methacrylate (DMAEMA) using p(THP-HEMA) as a macro chain transfer agent (mCTA). The degree of polymerization (DP) of the p(THP-HEMA) block was fixed to 35, whereas the DP of the p(DMAEMA) block was systematically varied from 21 to 50...
August 15, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28731680/nitrilotriacetic-amine-functionalized-polymeric-core-shell-nanoparticles-as-enzyme-immobilization-supports
#12
Dominic Keller, Ana Beloqui, Mónica Martínez-Martínez, Manuel Ferrer, Guillaume Delaittre
Nitrilotriacetic amine (NTA)-functionalized nanoparticles obtained by aqueous polymerization-induced self-assembly (PISA) are introduced as immobilization supports for polyhistidine-functionalized (His-tagged) enzymes. A novel initiator for nitroxide-mediated polymerization based on the nitroxide SG1 and carrying a protected NTA moiety was first synthesized. Size-exclusion chromatography (SEC) and electrospray ionization mass spectrometry (ESI-MS) proved the ability of this initiator to produce well-defined end-functional vinyl polymers...
August 15, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28806522/development-of-a-recombinant-multifunctional-biomacromolecule-for-targeted-gene-transfer-to-prostate-cancer-cells
#13
Arash Hatefi, Zahra Karjoo, Alireza Nomani
The objective of this study was to genetically engineer a fully functional single chain fusion peptide composed of motifs from diverse biological and synthetic origins that can perform multiple tasks including DNA condensation, cell targeting, cell transfection, particle shielding from immune system and effective gene transfer to prostate tumors. To achieve the objective, a single chain biomacromolecule (vector) consisted of four repetative units of histone H2A peptide, fusogenic peptide GALA, short elastin-like peptide and PC-3 cell targeting peptide was designed...
August 14, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28806066/thiol-mediated-synthesis-of-hyaluronic-acid-epigallocatechin-3-o-gallate-conjugates-for-the-formation-of-injectable-hydrogels-with-free-radical-scavenging-property-and-degradation-resistance
#14
Chixuan Liu, Ki Hyun Bae, Atsushi Yamashita, Joo Eun Chung, Motoichi Kurisawa
Hyaluronic acid (HA)-based biomaterials have demonstrated only limited in vivo stability as a result of rapid degradation by hyaluronidase and reactive oxidative species. The green tea catechin, (-)-epigallocatechin-3-O-gallate (EGCG), has received considerable attention because of its powerful antioxidant and enzyme-inhibitory activities. We describe here the synthesis of HA-EGCG conjugate using a thiol-mediated reaction and its use for the preparation of a long-lasting injectable hydrogel. HA-EGCG conjugates with tunable degrees of substitution were synthesized by the nucleophilic addition reaction between EGCG quinone and thiolated HA under mild conditions...
August 14, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28806059/bis-pyrene-doped-cationic-dipeptide-nanoparticles-for-two-photon-activated-photodynamic-therapy
#15
Bingbing Sun, Lei Wang, Qi Li, Ping-Ping He, Huiling Liu, Hao Wang, Yang Yang, Junbai Li
At present, one of main problems for photodynamic therapy (PDT) is how to improve the treatment depth. Two-photon activated (TPA) developed recently provide a possible solution for it. In this work, we report the energy-transferring assembled cationic dipeptide nanoparticles for two-photon activated photodynamic therapy (TPA-PDT). In the nanoparticles, the co-encapsulated two-photon fluorescent dye bis(pyrene) (BP) is an energy donor and a photosensitizer rose bengal (RB) is an acceptor based on an intraparticle fluorescence resonance energy transfer (FRET) mechanism...
August 14, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28806055/selective-release-system-for-antioxidative-and-anti-inflammatory-activities-using-h2o2-responsive-therapeutic-nanoparticles
#16
A Young Kim, Ji Hoon Ha, Soo Nam Park
We developed nanoparticles that were degraded by H2O2, a reactive oxygen species (ROS), to study a drug delivery system that targets damaged skin cells with oxidative stress and inflammation. In this study, tyrosol-incorporated copolyoxalate (TPOX) was synthesized by using 1,4-cyclohexanedimethanol, 4-(2-hydroxyethyl)phenol (tyrosol) and oxalyl chloride (Mw ~8835 Da). In vitro drug release behavior was assessed by loading nile red, a lipophilic fluorescent material such as quercetin, into the TPOX nanoparticles...
August 14, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28799758/ph-sensitive-interactions-between-cellulose-nanocrystals-and-dopc-liposomes
#17
Yotam Navon, Harisoa Radavidson, Jean-Luc Putaux, Bruno Jean, Laurent Heux
The interaction of DOPC vesicles with cellulose nanocrystals (CNCs) have been investigated using several complementary techniques. Dynamic light scattering, zeta-potential, cryo-transmission electron microscopy and isothermal titration calorimetry (ITC) analyses confirmed the formation of pH-dependent CNC-liposome complexes. ITC was used to characterize the thermodynamic properties of this interaction. Positive values of enthalpy were found at pH lower than 5 where the charge sign of the constituents was opposite...
August 11, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28799757/immobilization-of-growth-factors-to-collagen-surfaces-using-visible-light
#18
Gabriella Maria Fernandes Cunha, Hyun Jong Lee, Alisha Kumar, Alexander Kreymerman, Sarah Christine Heilshorn, David Myung
In the treatment of traumatic injuries, burns, and ulcers of the eye, inadequate epithelial tissue healing remains a major challenge. Wound healing is a complex process involving the temporal and spatial interplay between cells and their extracellular milieu. It can be impaired by a variety of causes including infection, poor circulation, loss of critical cells and/or proteins, and a deficiency in normal neural signaling (e.g. neurotrophic ulcers). Ocular anatomy is particularly vulnerable to lasting morbidity from delayed healing, whether it be scarring or perforation of the cornea, destruction of the conjunctival mucous membrane, or cicatricial changes to the eyelids and surrounding skin...
August 11, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28792747/the-effect-of-water-on-rheology-of-native-cellulose-ionic-liquids-solutions
#19
Behzad Nazari, Nyalaliska Utomo, Ralph H Colby
Cellulose coagulates upon adding water to its solutions in ionic liquids. Although cellulose remains in solution with much higher water contents, here we report the effect of 0-3 wt.% water on solution rheology of cellulose in 1-butyl-3-methylimidazolium chloride (BMImCl) and 1-ethyl-3-methylimidazolium acetate (EMImAc). Fourier transform infrared (FTIR) spectroscopy, thermal gravimetric analysis (TGA), and polarized light microscopy were also used to study water absorbance to the solutions. Tiny amounts of water (0...
August 9, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28792743/a-paradigm-shift-for-preparing-versatile-m2-free-gels-from-unmodified-sodium-alginate
#20
Maria M Pérez-Madrigal, Juan Torras, Jordi Casanovas, Marleen Häring, Carlos Aleman, David Díaz Díaz
This manuscript describes a new route to prepare rapidly Ca2+-free hydrogels from unmodified sodium alginate by simply mixing with small organic molecules such as polycarboxylic acid compounds as cross-linker agents instead of classical divalent metal salts such as CaCl2. DMSO was also found to induce the rapid gelation of aqueous alginate solutions. The gelation process takes place at RT and depending on the composition, gels with good thermal (90-100 °C) and mechanical properties compared to classical metal-containing analogs are obtained...
August 9, 2017: Biomacromolecules
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