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Biomacromolecules

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https://www.readbyqxmd.com/read/30433770/modification-of-poly-ethylene-2-5-furandicarboxylate-with-bio-based-1-5-pentanediol-significantly-toughened-copolyesters-retaining-high-tensile-strength-and-o2-barrier-property
#1
Hongzhou Xie, Linbo Wu, Bo-Geng Li, Philippe Dubois
Poly(ethylene 2,5-furandicarboxylate) (PEF) is a bio-based polyester characterized by high gas barrier properties as well as high tensile modulus and strength, but poor toughness. Toughening PEF without sacrificing its modulus, strength and gas barrier performance is a great challenge for PEF modification. In this study, high molecular weight random poly(ethylene-co-1,5-pentylene 2,5-furandicarboxylate)s (PEPeFs) were synthesized via melt copolycondensation of 2,5-furandicarboxylic acid (FDCA), ethylene glycol (EG) and 1,5-pentanediol (PeDO), a cheap, bio-based and commercially available odd-carbon comonomer...
November 15, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/30433767/use-of-light-degradable-aliphatic-polycarbonate-nanoparticles-as-drug-carrier-for-photosensitizer
#2
Jingjiang Sun, Wolfgang Birnbaum, Juliane Anderski, Marie-Theres Picker, Dennis Mulac, Klaus Langer, Dirk Kuckling
Aliphatic poly(carbonate)s (APCs) with rapid and controlled degradation upon specific stimulation have great advantages for a variety of biomedical and pharmaceutical applications. In the present work, we reported a new poly(trimethylene carbonate) (PTMC)-based copolymer containing multiple 4,5-dimethoxy-2-nitrobenzyl photo cleavable groups as pendent chains. The six-membered light-responsive cyclic carbonate monomer (LrM) was first prepared from 2-(hydroxymethyl)-2-methylpropane-1,3-diol and 4,5-dimethoxy-2-nitrobenzyl alcohol, and then copolymerized with trimethylene carbonate (TMC) by 1,8-diazabicyclo(5...
November 15, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/30433766/blocking-free-and-substrate-independent-serological-microarray-immunoassays
#3
Frank D Scherag, Andreas Mader, Marc Zinggeler, Nicole Birsner, Richard E Kneusel, Thomas Brandstetter, Jürgen Rühe
In bioanalytical applications, many coating strategies have been established for so-called "blocking" of the surfaces. However, most of the procedures developed so far require additional processing steps for surface blocking and small variations in the blocking efficiency result in increased background noise, which lowers the overall sensitivity of an assay. In this study, we demonstrate the preparation of a bioanalytical surface with a thin film of a photo-crosslinkable copolymer that is transformed photochemically into a surface-attached hydrogel network...
November 15, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/30428671/uniform-symmetric-and-asymmetric-polymer-nanostructures-via-directed-chain-organization
#4
Valentin A Bobrin, Sung-Po R Chen, Zhongfan Jia, Michael J Monteiro
Polymer nanostructures can be designed with specific properties and functions, such as controlled shape, size, chemical composition, and adaptive ability to change shape or size in response to environmental cues. Precise control to organize polymer chains into uniform nonspherical symmetric and asymmetric nanostructures and at scale remains a synthetic challenge. Here, by using the temperature-directed morphology transformation (TDMT) method, we show through a systematic organization of polymer chains the synthesis of well-defined asymmetric (i...
November 14, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/30427659/avidin-biotin-cross-linked-microgel-multilayers-as-carriers-for-antimicrobial-peptides
#5
Lina Nyström, Noor Al-Rammahi, Sara Malekkhaiat Häffner, Adam A Strömstedt, Kathryn L Browning, Martin Malmsten
Herein, we report on the formation of cross-linked antimicrobial peptide-loaded microgel multilayers. Poly(ethyl acrylate-co-methacrylic acid) microgels were synthesized and functionalized with biotin in order to enable the formation of microgel multilayers cross-linked with avidin. Microgel functionalization and avidin cross-linking were verified with infrared spectroscopy, dynamic light scattering, and z-potential measurements, while multilayer formation (up to four layers) was studied with null ellipsometry and quartz crystal microbalance with dissipation (QCM-D)...
November 14, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/30376297/effect-of-delivery-platforms-structure-on-the-epidermal-antigen-transport-for-topical-vaccination
#6
Ana S Sonzogni, Guy Yealland, Mrityunjoy Kar, Stefanie Wedepohl, Luis M Gugliotta, Verónica D G Gonzalez, Sarah Hedtrich, Marcelo Calderón, Roque J Minari
Transdermal immunization is highly attractive because of the skin's accessibility and unique immunological characteristics. However, it remains a relatively unexplored route of administration because of the great difficulty of transporting antigens past the outermost layer of skin, the stratum corneum. In this article, the abilities of three poly( N-vinylcaprolactam) (PVCL)-based thermoresponsive assemblies-PVCL hydrogels and nanogels plus novel film forming PVCL/acrylic nanogels-to act as protein delivery systems were investigated...
November 14, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/30422635/topological-transition-in-spontaneously-formed-cellulosic-liquid-crystalline-microspheres-in-a-w-o-emulsion
#7
Arindam Chakrabarty, Kazuma Miyagi, Monali Maiti, Yoshikuni Teramoto
A cholesteric liquid crystal (ChLC) in a confined space has attracted significant scientific interest and has potential applications. ChLC microspheres have been obtained by devising processing such as a microfluidic technique. Herein, we adopted the self-assembly approach for the spontaneous formation of cellulosic ChLC microspheres. A functional block copolymer (BCP) was grafted to hydroxypropyl cellulose (HPC), making it amphiphilic to self-assembly in a w/o emulsion. The HPC segment aggregated in the aqueous phase under lyotropic conditions and produced the ChLC microspheres dispersed in the oil phase...
November 13, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/30376309/degradable-and-injectable-hydrogel-for-drug-delivery-in-soft-tissues
#8
Vincent Pertici, Caroline Pin-Barre, Claudio Rivera, Christophe Pellegrino, Jérôme Laurin, Didier Gigmes, Thomas Trimaille
Injectable hydrogels are promising platforms for tissue engineering and local drug delivery as they allow minimal invasiveness. We have here developed an injectable and biodegradable hydrogel based on an amphiphilic PNIPAAm- b-PLA- b-PEG- b-PLA- b-PNIPAAm pentablock copolymer synthesized by ring-opening polymerization/nitroxide-mediated polymerization (ROP/NMP) combination. The hydrogel formation at around 30 °C was demonstrated to be mediated by intermicellar bridging through the PEG central block. Such a result was particularly highlighted by the inability of a PEG- b-PLA- b-PNIPAAm triblock analog of the same composition to gelify...
November 13, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/30418756/the-cinnamaldehyde-based-poly-ester-thioacetal-to-generate-reactive-oxygen-species-for-fabricating-ros-responsive-nanoparticles
#9
Long Xu, Mingying Zhao, Hai Zhang, Wenxia Gao, Zhaoyuan Guo, Xuequan Zhang, Jiangfeng Zhang, Jun Cao, Yuji Pu, Bin He
Reactive oxygen species (ROS)-responsive nanoparticles have attracted great interest for anticancer drug delivery. In this paper, a new ROS-responsive moiety, thioacetal, was designed and synthesized, cinnamaldehyde (CA) was introduced in the polymer chain to trigger the generation of ROS to expect the enhancement of ROS-responsive effect. The poly(ester-thioacetal) mPEG2k-b-(NTA-HD)12 polymer, its self-assembled micelles and the ROS-responsive behavior were characterized by 1H NMR and DLS. Anticancer drug doxorubicin (DOX) was loaded in the poly(ester-thioacetal) micelles...
November 12, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/30395450/preparation-of-amphiphilic-poly-ethylene-glycol-b-poly-%C3%AE-butyrolactone-diblock-copolymer-via-ring-opening-polymerization-catalyzed-by-a-cyclic-trimeric-phosphazene-base-or-alkali-alkoxide
#10
Yong Shen, Jinbo Zhang, Zhichao Zhao, Na Zhao, Fusheng Liu, Zhibo Li
Biobased poly(γ-butyrolactone) (PγBL) as a fully biodegradable and bioabsorbable biomaterial has shown superior properties compared to those of other aliphatic polyesters. It is of great importance to prepare amphiphilic block copolymer containing PγBL block to make ordered nano-objects for biomedical applications such as drug delivery systems. However, such an amphiphilic copolymer containing PγBL segment was never successfully prepared mostly due to the synthetic challenges of ring-opening polymerization (ROP) of nonstrained γ-butyrolactone (γBL) monomer...
November 12, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/30412396/biodegradable-polyglycerol-sulfates-exhibit-promising-features-for-anti-inflammatory-applications
#11
Magda Ferraro, Kim Silberreis, Ehsan Mohammadifar, Falko Neumann, Jens Dernedde, Rainer Haag
Inflammatory processes are beneficial responses to overcome injury or illness. Knowledge of the underlying mechanisms allows for a specific treatment. Thus, synthetic systems can be generated for a targeted interaction. In this context, dendritic polyglycerol sulfates (dPGS) have been investigated as anti-inflammatory compounds. Biodegradable systems are required to prevent compound accumulation in the body. Here we present biodegradable analogs of dPGS based on hyperbranched poly(glycidol-co-caprolactone) bearing a hydrophilic sulfate outer shell (hPG-co-PCLS)...
November 9, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/30412387/highly-transparent-strong-and-flexible-films-with-modified-cellulose-nanofiber-bearing-uv-shielding-property
#12
Xun Niu, Yating Liu, Guigan Fang, Chaobo Huang, Orlando J Rojas, Hui Pan
This work investigates multifunctional composite films synthesized with cellulose nanofibers (CNFs) and poly (vinyl alcohol) (PVA). First, TEMPO-oxidized CNFs were modified in heterogeneous phase with benzophenone, diisocyanate and epoxidized soybean oil via esterification reactions. A thorough characterization was carried out via elemental analysis as well as FT-IR, X-ray photoelectron spectroscopies, and solid-state NMR. Following, the surface-modified CNFs where combined with PVA to endow composite films with UV-absorbing capabilities while increasing their thermo-mechanical strength and maintaining a high light transmittance...
November 9, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/30412385/a-synergy-of-key-properties-promotes-dendrimer-conjugates-as-prospective-ratiometric-bioresponsive-mri-probes
#13
Liam Connah, Goran Angelovski
Bioresponsive or smart contrast agents (SCAs) sensitive to Ca2+ are of extreme interest in the development of functional magnetic resonance imaging (MRI) techniques as they can aid in tracking neural activity in vivo. To this end, the design of macromolecular systems based on nanoscaffolds such as dendrimers functionalised with multiple MRI contrast agents have been used to conveniently increase the local concentration of paramagnetic MR reporters and slow the diffusion time of the probe, which are favourable in vivo characteristics...
November 9, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/30380842/radiolabeled-molecular-imaging-probes-for-the-in-vivo-evaluation-of-cellulose-nanocrystals-for-biomedical-applications
#14
Surachet Imlimthan, Sofia Otaru, Outi Keinänen, Alexandra Correia, Kalle Lintinen, Hélder A Santos, Anu J Airaksinen, Mauri A Kostiainen, Mirkka Sarparanta
Cellulose nanocrystals (CNCs) have remarkable potential to improve the delivery of diagnostic and therapeutic agents to tumors; however, the in vivo studies on CNC biodistribution are still limited. We developed CNC-based imaging probes for the in vitro and in vivo evaluation using two labeling strategies: site-specific hydrazone linkage to the terminal aldehyde of the CNC and nonsite-specific activation using 1,1'-carbonyldiimidazole (CDI). The in vivo behavior of unmodified CNC, DOTA-CNC (ald.), and DOTA-CNC (OH) was investigated in healthy and 4T1 breast cancer mouse models...
November 9, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/30407801/dna-polymer-conjugates-by-photo-induced-raft-polymerization
#15
Thorsten Lückerath, Tina Strauch, Kaloian Koynov, Christopher Barner-Kowollik, David Ng, Tanja Weil
Conventional grafting-to approaches to DNA-polymer conjugates are often limited by low reaction yields due to the sterically hindered coupling of a pre-synthesized polymer to DNA. The grafting-from strategy, in contrast, allows to directly graft polymers from an initiator that is covalently attached to DNA. Herein, we report blue light-mediated reversible addition-fragmentation chain-transfer (Photo-RAFT) polymerization from two different RAFT agent-terminated DNA sequences. Three monomer families (methacrylates, acrylates and acrylamides) were successfully polymerized from DNA via the Photo-RAFT procedure...
November 8, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/30406987/correction-to-switching-from-controlled-ring-opening-polymerization-crop-to-controlled-ring-closing-depolymerization-crcdp-by-adjusting-the-reaction-parameters-that-determine-the-ceiling-temperature
#16
Peter Olsén, Jenny Undin, Karin Odelius, Helmut Keul, Ann-Christine Albertsson
No abstract text is available yet for this article.
November 8, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/30365881/smart-ph-sensitive-nanogels-for-controlled-release-in-an-acidic-environment
#17
Peng Wei, Gauri Gangapurwala, David Pretzel, Meike N Leiske, Limin Wang, Stephanie Hoeppener, Stephanie Schubert, Johannes C Brendel, Ulrich S Schubert
The encapsulation of therapeutic compounds into nanosized delivery vectors has become an important strategy to improve efficiency and reduce side effects in drug delivery applications. Here, we report the synthesis of pH-sensitive nanogels, which are based on the monomer N-[(2,2-dimethyl-1,3-dioxolane)methyl]acrylamide (DMDOMA) bearing an acid cleavable acetal group. Degradation studies revealed that these nanogels hydrolyze under acidic conditions and degrade completely, depending on the cross-linker, but are stable in physiological environment...
November 8, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/30403862/the-molecular-dance-of-fibronectin-conformational-flexibility-leads-to-functional-versatility
#18
Raffaele Mezzenga, Maria Mitsi
Fibronectin, a large multimodular protein and one of the major fibrillar components of the extracellular matrix, has been the subject of study for many decades and plays critical roles in embryonic development and tissue homeostasis. Moreover, fibronectin has been implicated in the pathology of many diseases, including cancer, and abnormal depositions of fibronectin have been identified in a number of amyloid and non-amyloid lesions. The ability of fibronectin to carry all these diverse functionalities is through interactions with a large number of molecules, including adhesive and signaling cell surface receptors, other components of the extracellular matrix, and growth factors and cytokines...
November 7, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/30398849/lipase-catalyzed-regioselective-synthesis-of-dextrin-esters
#19
Hakyong Lee, Satoshi Kimura, Tadahisa Iwata
Four lipase enzymes were investigated as catalysts in the synthesis of regioselectively mono-substituted dextrin esters from dextrin and vinyl acetate. An immobilized lipase enzyme (Lipozyme TL IM) exhibited the highest activity. This enzyme showed regioselective substitution of the dextrin at the primary hydroxyl group (C6 position) under optimal conditions (60°C for 24 hours, using a 1:3 molar ratio of glucose unit/vinyl acetate and 2.5 U/mL enzyme dosage in an organic solvent). To compare the reactivity of other vinyl esters, mono-substituted dextrin esters (degrees of substitution [DS] ≈ 1) with varying side-chain lengths (C2-12) were synthesized...
November 6, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/30360619/cellulose-derived-nanographene-oxide-surface-functionalized-three-dimensional-scaffolds-with-drug-delivery-capability
#20
Nejla B Erdal, Jenevieve G Yao, Minna Hakkarainen
Multifunctional three-dimensional (3D) scaffolds were targeted by surface grafting cellulose-derived nanographene oxide (nGO) on the surface of porous poly(ε-caprolactone) (PCL) scaffolds. nGO was derived from cellulose by microwave-assisted carbonization process and covalently grafted onto aminolyzed PCL scaffolds through an aqueous solution process. Fourier transform infrared spectroscopy and thermogravimetric analysis both verified the successful attachment of nGO and scanning electron microscopy depicted a homogeneous dispersion of nGO over the scaffold surface...
November 6, 2018: Biomacromolecules
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