journal
MENU ▼
Read by QxMD icon Read
search

Biomacromolecules

journal
https://www.readbyqxmd.com/read/28631927/stabilization-of-a-virus-like-particle-and-its-application-as-a-nanoreactor-at-physiological-conditions
#1
Lise Schoonen, Sjors Maassen, Roeland J M Nolte, Jan C M van Hest
Virus-like particles are very interesting tools for application in bio-nanotechnology, due to their monodisperse features and biocompatibility. In particular, the cowpea chlorotic mottle virus (CCMV) capsid has been studied extensively as it can be assembled and disassembled reversibly, facilitating cargo encapsulation. CCMV is, however, only stable at physiological conditions when its endogenous nucleic acid cargo is present. To gain more flexibility in the type of cargo encapsulated and to broaden the window of operation, it is interesting to improve the stability of the empty virus-like particles...
June 20, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28631478/drying-affects-the-fiber-network-in-low-molecular-weight-hydrogels
#2
Laura L E Mears, Emily R Draper, Ana M Castilla, Hao Su, Zhuola Zhuola, Bart Dietrich, Michael Nolan, Gregory N Smith, James Doutch, Sarah E Rogers, Riaz Akhtar, Honggang Cui, Dave J Adams
Low molecular weight gels are formed by the self-assembly of a suitable small molecule gelator into a three-dimensional network of fibrous structures. The gel properties are determined by the fiber structures, the number and type of cross-links and the distribution of the fibers and cross-links in space. Probing these structures and cross-links is difficult. Many reports rely on microscopy of dried gels (xerogels), where the solvent is removed prior to imaging. The assumption is made that this has little effect on the structures, but it is not clear that this assumption is always (or ever) valid...
June 20, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28628303/folate-and-heptamethine-cyanine-modified-chitosan-based-nanotheranostics-for-tumor-targeted-near-infrared-fluorescence-imaging-and-photodynamic-therapy
#3
Yingying Zhang, Tingting Lv, Huijuan Zhang, Xiaodong Xie, Ziying Li, Haijun Chen, Yu Gao
Folate (FA) and heptamethine cyanine (Cy7)-modified chitosan (CF7) was synthesized by click chemistry and its self-assembled nanoparticles (CF7Ns) were developed for tumor-specific imaging and photodynamic therapy. The characterization spectrum confirmed CF7 had a good FA and Cy7 conjugation efficacy. The diameter of CF7Ns measured by DLS was about 291.6 nm and the morphology observed with AFM showed filamentous clusters of particles. The results of targeting ability of CF7Ns demonstrated enhanced targeting behaviors of CF7Ns compared with non-FA-modified nanoparticles C7Ns in FA receptor-positive HeLa cells...
June 19, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28621927/hemocompatibility-of-degrading-polymeric-biomaterials-degradable-polar-hydrophobic-ionic-polyurethane-d-phi-vs-poly-lactic-co-glycolic-acid-plga
#4
Kathryne Saini Brockman, Benjamin F L Lai, Jayachandran N Kizhakkedathu, J Paul Santerre
The use of degradable polymers in vascular tissue regeneration has sparked the need to characterize polymer biocompatibility during degradation. While tissue compatibility has been frequently addressed, studies on polymer hemocompatibility during degradation are limited. The current study evaluated the differences in hemocompatibility (platelet response, complement activation, and coagulation cascade initiation) between as-made and hydrolyzed poly(lactic-co-glycolic) acid (PLGA) and degradable polar hydrophobic ionic polyurethane (D-PHI)...
June 16, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28618228/mechanical-properties-and-cell-compatibility-of-agarose-hydrogels-containing-proteoglycan-mimetic-graft-copolymers
#5
Hannah M Pauly, Laura W Place, Tammy L Haut Donahue, Matt J Kipper
Proteoglycans have vital biochemical and biomechanical functions. Their proteolytic degradation results in loss of these functions. We have previously reported non-protein proteoglycan-mimetic graft copolymers that stabilize and deliver growth factors and are not subject to proteases. Here we expand our investigation of these proteoglycan mimics by also investigating their effects on hydrogel mechanical properties. Four polysaccharide side chains - chondroitin sulfate, heparin, dextran, and dextran sulfate - are each grafted to a hyaluronan backbone...
June 15, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28618219/hierarchical-microspheres-constructed-from-chitin-nanofibers-penetrated-hydroxyapatite-crystals-for-bone-regeneration
#6
Bo Duan, Kangquan Shou, Xiaojuan Su, Yahui Niu, Guan Zheng, Yao Huang, Ai-Xi Yu, Yu Zhang, Hong Xia, Lina Zhang
Chitin exists abundantly in the crab and shrimp shell as the template of the minerals, which inspired us to mineralize it for fabricating the bone grafting materials. In present work, chitin nanofibrous microspheres were used as the matrix for in situ synthesisof the hydroxyapatite (HA) crystals including micro-flake, submicron-needle and submicron-osphere, which were penetrated by long chitin nanofibers, leading to the hierarchical structure. The shape and size of the HA crystals could be controled by changing the HA synthesisprocess...
June 15, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28617594/formation-of-polyrotaxane-particles-via-template-assembly
#7
Blaise L Tardy, Shereen Tan, Henk H Dam, Tomoya Suma, Junling Guo, Greg G Qiao, Frank Caruso
In this study, we report a versatile method to assemble tunable poly(ethylene glycol) (PEG)-based polyrotaxane (PRX) particles and capsules. By threading α-cyclodextrins (αCDs) onto PEG chains physically adsorbed onto template particles and subsequently dissolving the templates, PRX replica particles and hollow capsules are formed. This approach overcomes issues related to CD steric hindrance, and also reduces the multiple processing steps often associated with PRX-based particle formation. By simple variation of the molecular weight and end-group functionality of the PEG, we show that the rate of particle degradation as well as the stability of the particles can be tuned...
June 15, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28616970/the-structure-and-biocompabibility-of-bioabsorbable-nanocomposites-of-aliphatic-aromatic-co-polyester-and-cellulose-nanocrystals
#8
Shahab Kashani Rahimi, Robabeh Aeinehvand, Kyoungtae Kim, Joshua U Otaigbe
Poly(butylene adipate-co-terephthalate) (PBAT) was first chemically modified via free radical grafting with maleic anhydride (MA) and the MA-g-PBAT graft copolymer was then used as a matrix material to obtain cellulose nanocrystal (CNC)-reinforced MA-g-PBAT bio-nanocomposites via reactive extrusion process to accelerate efforts to develop functional bioabsorbable polymer nanocomposites with improved properties. The molecular structure of the PBAT after chemical modification with maleic anhydride was confirmed by 1H NMR and FTIR spectroscopy...
June 15, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28578565/conditional-network-assembly-and-targeted-protein-retention-via-environmentally-responsive-engineered-%C3%AE-roll-peptides
#9
Beyza Bulutoglu, Sarah J Yang, Scott Banta
Stimulus-responsive biomaterials have applications in many areas of biotechnology, such as tissue engineering, drug delivery, and bioelectrocatalysis. The intrinsically disordered repeat-in-toxin (RTX) domain is a conformationally dynamic peptide that gains β-roll secondary structure when bound to calcium ions. A smart hydrogel platform was constructed by genetically fusing two rationally designed mutant RTX domains: first, a mutant peptide with hydrophobic interfaces capable of calcium-dependent network assembly, and second, another mutant that conditionally binds the model target protein lysozyme...
June 15, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28530806/photoluminescent-hybrids-of-cellulose-nanocrystals-and-carbon-quantum-dots-as-cytocompatible-probes-for-in-vitro-bioimaging
#10
Jiaqi Guo, Dongfei Liu, Ilari Filpponen, Leena-Sisko Johansson, Jani-Markus Malho, Sakeena Quraishi, Falk Liebner, Hélder A Santos, Orlando J Rojas
We present an approach to construct biocompatible and photoluminescent hybrid materials comprised of carbon quantum dots (CQDs) and TEMPO-oxidized cellulose nanocrystals (TO-CNCs). First, the amino-functionalized carbon quantum dots (NH2-CQDs) were synthesized using a simple microwave method, and the TO-CNCs were prepared by hydrochloric acid (HCl) hydrolysis followed by TEMPO-mediated oxidation. The conjugation of NH2-CQDs and TO-CNCs was conducted via carbodiimide-assisted coupling chemistry. The synthesized TO-CNC@CQD hybrid nanomaterials were characterized using X-ray photoelectron spectroscopy, cryo-transmittance electron microscopy, confocal microscopy, and fluorescence spectroscopy...
June 15, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28613846/unimolecular-micelle-based-hybrid-system-for-perivascular-drug-delivery-produces-long-term-efficacy-for-neointima-attenuation-in-rats
#11
Guojun Chen, Xudong Shi, Bowen Wang, Ruosen Xie, Lian-Wang Guo, Shaoqin Gong, K Craig Kent
At present, there are no clinical options for preventing neointima-caused (re)stenosis after open surgery such as bypass surgery for treating flow-limiting vascular disease. Perivascular drug delivery is a promising strategy, but in translational research, it remains a major challenge to achieve long-term (e.g., > 3 months) anti(re)stenotic efficacy. In this study, we engineered a unique drug delivery system consisting of durable unimolecular micelles, formed by single multiarm star amphiphilic block copolymers with only covalent bonds, and a thermosensitive hydrogel formed by a poly(lactide-co-glycolide)-poly(ethylene glycol)-poly(lactide-co-glycolide) triblock copolymer (abbreviated as triblock gel) that is stable for about 4 weeks in vitro...
June 14, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28535058/peo-ppo-diblock-copolymers-protect-myoblasts-from-hypo-osmotic-stress-in-vitro-dependent-on-copolymer-size-composition-and-architecture
#12
Mihee Kim, Karen J Haman, Evelyne M Houang, Wenjia Zhang, Demetris Yannopoulos, Joseph M Metzger, Frank S Bates, Benjamin J Hackel
Poloxamer 188, a triblock copolymer of poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO), protects cellular membranes from various stresses. Though numerous block copolymer variants exist, evaluation of alternative architecture, composition, and size has been minimal. Herein, cultured murine myoblasts are exposed to the stresses of hypotonic shock and isotonic recovery, and membrane integrity was evaluated by quantifying release of lactate dehydrogenase. Comparative evaluation of a systematic set of PEO-PPO diblock and PEO-PPO-PEO triblock copolymers demonstrates that the diblock architecture can be protective in vitro...
June 14, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28609610/an-rna-aptamer-capable-of-forming-hydrogel-by-self-assembly
#13
Zhen Huang, Gagan N Kangovi, Wei Wen, Sangwoo Lee, Li Niu
Hydrogels are supramolecular assemblies with both solute transport properties like liquids and mechanical properties like elastomers. To date, every type of biomolecules, except ribonucleic acid (RNA), are capable of forming hydrogel. Here we report an RNA that forms hydrogel by self-assembly. This RNA is originally identified by systematic evolution of ligands by exponential enrichment (SELEX) to enhance the activity of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors as a potential RNA drug for treatment of cognitive disorders...
June 13, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28605182/%C3%AE-%C3%AF-diphenylalanine-end-capping-of-peg-ppg-peg-polymers-changes-the-micelle-morphology-and-enhances-stability-of-the-thermogel
#14
Hae An Kim, Hyun Jung Lee, Ja Hye Hong, Hyo Jung Moon, Du Young Ko, Byeongmoon Jeong
Pluronics F127 (P, PEG-PPG-PEG triblock copolymer) was coupled with diphenylalanine (FF) to prepare FF-end-capped Pluronics (FFPFF). With increasing temperature from 10 to 60 oC, the FFPFF self-assembled to vesicles in water. The unimer-to-vesicle transition accompanies endothermic enthalpy of 53.9 Kcal/mol. Aqueous P and FFPFF solutions exhibited thermogelation in 15.0-24.0 wt.%. The gel phase of FFPFF was stable up to 90 oC whereas that of P turned into a sol again at 55-86 oC, indicating that end-capping with FF improved the gel stability against heat...
June 12, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28605176/reduction-and-ph-sensitive-hyaluronan-nanoparticles-for-delivery-of-iridium-iii-anticancer-drugs
#15
Zhixiang Cai, Hongbin Zhang, Yue Wei, Yuanyuan Wei, Yanping Xie, Fengsong Cong
The organoiridium(III) complex (Ir(III)) [(η5-Cpxbiph)Ir(phpy)(py)]PF6 containing π-bonded biphenyltetramethylcyclopentadienyl(Cpxbiph), C^N-chelated phenylpyridine(phpy), and pyridine (py) ligands has more potent antitumor activity as a new generation of drug than cisplatin toward various cancer cells. However, poor site-specific delivery, low solubility, and poor tumor penetration are common limitations of chemotherapy drugs. To develop CD44-targetable, pH-, and reduction-responsive drug delivery systems for Ir(III) drugs, the amphiphilic hyaluronan (HA)-based conjugates of HA-cystamin-pyrenyl (HA-ss-Py) containing disulfide bonds and HA-pyrenyl (HA-Py) were designed...
June 12, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28603980/sericin-promotes-fibroin-silk-i-stabilization-across-a-phase-separation
#16
Hyo Won Kwak, Ji Eun Ju, Munju Shin, Chris Holland, Ki Hoon Lee
Natural silk spinning offers several advantages over the synthetic fiber spinning, although the underlying mechanisms of this process are yet to be fully elucidated. Silkworm silks, specifically which of B. mori, comprise of two main proteins; fibroin, which forms the fiber, and sericin, a co-extruded coating which acts as a matrix in the resulting non-woven composite cocoon. To date, most studies have focused on fibroins' self-assembly and gelation, with the influence of sericin during spinning receiving little to no attention...
June 12, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28561567/clathrin-independent-killing-of-intracellular-mycobacteria-and-biofilm-disruptions-using-synthetic-antimicrobial-polymers
#17
Prabhu S Yavvari, Siddhi Gupta, Divya Arora, Vinay K Nandicoori, Aasheesh Srivastava, Avinash Bajaj
Current membrane targeting antimicrobials fail to target mycobacteria due to their hydrophobic membrane structure, ability to form drug-resistant biofilms, and their natural intracellular habitat within the confines of macrophages. In this work, we describe engineering of synthetic antimicrobial polymers (SAMPs) derived from biocompatible polyamides that can target drug-sensitive and drug-resistant mycobacteria with high selectivity. Structure-activity relationship studies revealed that reduced hydrophobicity of cationic pendants induces enhanced and selective permeabilization of mycobacterial membranes...
June 12, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28558194/adaptive-chitosan-hollow-microspheres-as-efficient-drug-carrier
#18
Ya-Nan Fu, Yongsan Li, Guofeng Li, Lei Yang, Qipeng Yuan, Lei Tao, Xing Wang
Smart drug carrier with function-oriented adaptations is highly desired due to its unique properties in medical applications. Herein, adaptive chitosan hollow microspheres (CHM) are fabricated by employing interfacial Schiff-base bonding reaction. Hydrophilic macromolecules of glycol chitosan are fixed at the oil/water interface through numerous hydrophobic small molecules of borneol 4-formylbenzoate, forming the CHM with a positively charged surface and lipophilic cavity. These CHM have an average size of 400-1000 nm after passing through the 0...
June 7, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28535062/supramolecular-hydrogel-formation-in-a-series-of-self-assembling-lipopeptides-with-varying-lipid-chain-length
#19
V Castelletto, A Kaur, R M Kowalczyk, I W Hamley, M Reza, J Ruokolainen
The self-assembly in aqueous solution of three lipopeptides comprising a bioactive motif conjugated at the N terminus to dodecyl, tetradecyl or hexadecyl lipid chains has been examined. The bioactive motif is the peptide block YEALRVANEVTLN; a C-terminal fragment of the lumican proteoglycan. This study was motivated by our previous studies on the hexadecyl homologue C16-YEALRVANEVTLN, which showed aggregation into β-sheet structures above a critical aggregation concentration (cac), but most remarkably, we found that these aggregates were stable to dilution below the cac...
June 5, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28574695/fabrication-of-silk-scaffolds-with-nano-microscaled-structures-and-tunable-stiffness
#20
Liying Xiao, Shanshan Liu, Danyu Yao, Zhaozhao Ding, Zhihai Fan, Qiang Lu, David L Kaplan
Detailed control of nano- and microstructures in porous biomaterial scaffold systems is important for control of interfacial and biological functions. Self-assembled silk protein nanostructured building blocks were incorporated into salt-leached scaffolds to control these features. Controllable concentration and pH were used to induce the formation of amorphous silk nanofibers in solution and also to reduce beta-sheet transformation during the more traditional salt-leaching process. These new scaffolds showed nanofibrous-microporous structures, reduced beta-sheet content, and tunable mechanical properties...
June 2, 2017: Biomacromolecules
journal
journal
34768
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"