Yumi Elena Nakazawa-Ueji, Guillermo Valencia-Pacheco, Lizbeth Josefina González-Herrera, Laureano Chan-Chalé, Rubí Misol-Ha Velasco-Cárdenas, Martha Julia Carreño-Gonzalez, Gerardo Pérez-Mendoza, Guadalupe Isabel Amaro-Adrián, Edwin Arturo Rodríguez-Dzul, Irma Guadalupe Quintal-Ortiz, Angélica Vanesa Angulo-Ramírez, Ricardo Francisco López-Villanueva
Introduction: IFN-α is the main cytokine in SLE, and single nucleotide polymorphisms (SNP) in different genes could induce it. Aim: To determine the association of rs2004640 ( IRF5 ), rs179008 ( TLR7 ), rs1800795 ( IL-6 ) and rs2280788 ( CCL5 ) with SLE in Mexican women with Mayan ethnicity. Methods: DNA and RNA were isolated from the peripheral blood of 110 patients and 200 healthy control subjects. SNP genotyping and gene expression analysis of IRF5, TLR7, IL-6 and IFN-α were determined by real-time PCR and analyzed with SNP Stat, Stata 10...
March 8, 2024: Nucleosides, Nucleotides & Nucleic Acids