Mohammed Al-Onaizi, Kawthar Braysh, Selma S Alkafeef, Dana Altarrah, Shorouk Dannoon, Dalal Alasousi, Hawraa Adel, Mariam Al-Ajmi, Anwar Kandari, Rawan Najem, Rasheeba Nizam, Michayla R Williams, Sumi John, Thangavel Alphonse Thanaraj, Rasheed Ahmad, Heba Al-Hussaini, Fahd Al-Mulla, Fawaz Alzaid
OBJECTIVES: Type 2 diabetes (T2D) is a metabolic disease of major public health concern. It impacts peripheral tissues and the central nervous system, leading to systemic dysmetabolism and neurocognitive impairments, including memory deficits, anxiety, and depression. The metabolic determinants of these neurocognitive impairments remain unidentified. Here, we sought to address this question by developing a proprietary (P-) high-fat diet (HFD), in which glucose intolerance precedes weight gain and insulin resistance...
February 6, 2024: Nutritional Neuroscience