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Nutritional Neuroscience

Eftyhia Tsagalioti, Christina Trifonos, Aggeliki Morari, Konstantinos Vadikolias, Constantinos Giaginis
Neurodegenerative diseases constitute a major problem of public health that is associated with an increased risk of mortality and poor quality of life. Malnutrition is considered as a major problem that worsens the prognosis of patients suffering from neurodegenerative diseases. In this aspect, the present review is aimed to critically collect and summarize all the available existing clinical data regarding the clinical impact of nutritional assessment in neurodegenerative diseases, highlighting on the crucial role of nutritional status in disease progression and management...
November 30, 2016: Nutritional Neuroscience
Deborah P Waber, Cyralene P Bryce, Jonathan M Girard, Laura K Fischer, Garrett M Fitzmaurice, Janina R Galler
OBJECTIVES: We compared the IQ and academic achievement of the young adult offspring of parents malnourished in infancy and those of a healthy control group in order to test the hypothesis that the offspring of previously malnourished individuals would show IQ and academic deficits that could be related to reduced parental socioeconomic status. METHODS: We conducted a group comparison study based on a community sample in Barbados (Barbados Nutrition Study). Participants were adult children ≥16 years of age whose parents had been malnourished during the first year of life (n = 64; Mean age 19...
November 25, 2016: Nutritional Neuroscience
Nora Schneider, Gisella Mutungi, Javier Cubero
OBJECTIVES: The establishment of organized sleep patterns is an important developmental process during infancy. Little is known about the role of nutrition in sleep maturation. This review focuses on exploring the link between infant sleep and nutrition with the aim to provide an overview of existing literature on the impact of diet and specific nutrients on sleep modulation in infants. METHODS: An exploratory literature search was performed on the topic in Medline, Scopus and Cochrane Library databases, with a focus on publications in English...
November 21, 2016: Nutritional Neuroscience
M Atif Raza Cheema, Shazia Nawaz, Sumera Gul, Tabinda Salman, Sabira Naqvi, Ahsana Dar, Darakhshan J Haleem
OBJECTIVES: In the last few decades, therapeutic uses of medicinal compounds present in food as a normal constituent has risen substantially, largely because of their fewer side effects and adequate efficacy. This study is designed to investigate a role of brain serotonin (5-HT) and dopamine (DA) in the potential nootropic, anxiolytic, and other beneficial effects of Nigella sativa (NS) and Olea europaea (OE) oil in rat models. METHODS: Animals were treated with NS and OE oil orally at doses of 0...
November 21, 2016: Nutritional Neuroscience
Shinki Murakami, Ikuko Miyazaki, Masato Asanuma
OBJECTIVES: Nuclear factor erythroid 2-related factor (Nrf2) in astrocyte plays important roles in brain homeostasis. Fermented papaya preparation (FPP) has anti-oxidative, anti-inflammatory, immunoregulatory properties. The present study investigated the effects of FPP on activation of Nrf2 and release of Nrf2-regulated neuroprotective antioxidants and detoxifying molecules. METHODS: Primary cultured astrocytes from rat embryos were treated with FPP for 6 or 24 hours...
November 14, 2016: Nutritional Neuroscience
Nazanin Mohebali, Seyed Abolhassan Shahzadeh Fazeli, Hossein Ghafoori, Zeinab Farahmand, Elham MohammadKhani, Faezeh Vakhshiteh, Abdolreza Ghamarian, Mansoureh Farhangniya, Mohammad Hossein Sanati
OBJECTIVES: Alzheimer's disease (AD) is one of the most common forms of neurodegenerative diseases. Despite vast ongoing researches focusing on the area, little is known about novel treatments. In this study, we aimed to survey the effects of Capparis spinosa (C. spinosa) extract on amyloid-beta peptide (Aβ)-injected rat. METHODS: For this purpose, hydroalcoholic extracts of caper leaf and fruit were prepared. Total phenolic content, DPPH, and FRAP assay were accomplished to determine antioxidant activity of C...
October 25, 2016: Nutritional Neuroscience
Brandon P Lucke-Wold, Aric F Logsdon, Linda Nguyen, Ahmed Eltanahay, Ryan C Turner, Patrick Bonasso, Chelsea Knotts, Adam Moeck, Joseph C Maroon, Julian E Bailes, Charles L Rosen
Studies using traditional treatment strategies for mild traumatic brain injury (TBI) have produced limited clinical success. Interest in treatment for mild TBI is at an all time high due to its association with the development of chronic traumatic encephalopathy and other neurodegenerative diseases, yet therapeutic options remain limited. Traditional pharmaceutical interventions have failed to transition to the clinic for the treatment of mild TBI. As such, many pre-clinical studies are now implementing non-pharmaceutical therapies for TBI...
October 5, 2016: Nutritional Neuroscience
Mohammadreza Alizadeh-Ghodsi, Ali Zavvari, Abbas Ebrahimi-Kalan, Mohammad Reza Shiri-Shahsavar, Bahman Yousefi
Multiple sclerosis (MS) is a disease which manifests demyelination of neuronal cells in the brain. Despite extensive research on the mechanisms of disease development and progression, the exact mechanism is not elucidated yet, which has hampered drug development and subsequent treatment of the disease. We have recently shown that the serum levels of arsenic and malondialdehyde, a lipid peroxidation marker, are high in MS patients. In this article, we would like to formulate the hypothesis that arsenic may cause MS by induction of inflammation, degeneration, and apoptosis in neuronal cells...
October 4, 2016: Nutritional Neuroscience
Marisol Orozco-Ibarra, Jazmín García-Morales, Francisco José Calvo-Silva, Francisca Fernández-Valverde, Norma Serrano-García
BACKGROUND: Mitochondrial dysfunction is involved in neurodegenerative diseases, such as Huntington's disease (HD). 3-Nitropropionic acid (3-NP) is a mitochondrial toxin that specifically inhibits complex II of the electron transport chain (ETC) and is used to generate an experimental model of HD. OBJECTIVE: To study the effect of fish liver oil (FO) over the mitochondrial dysfunction induced via partial ETC inhibition by 3-NP. METHODS: This study was performed in rats and consisted of two phases: (i) administration of increasing doses of 3-NP and (ii) administration of FO for 14 days before to 3-NP...
September 28, 2016: Nutritional Neuroscience
Larissa de Brito Medeiros, Suênia Marcele Vitor-de-Lima, Regina de Deus Lira Benevides, Rita de Cássia Ramos do Egypto Queiroga, Rubem Carlos Araújo Guedes
OBJECTIVES: Goat whey, a usually discarded byproduct from goat cheese manufacturing, is a good source of sialic acid (SA), an oligosaccharide that is involved in processes such as memory and brain excitability. Here, we investigated in rats the effect of dried goat whey (DGW) on memory and the brain excitability-dependent phenomenon known as cortical spreading depression (CSD). We also provide evidence for the involvement of SA in this effect. In addition, we tested animals under unfavorable suckling conditions to evaluate whether nutritional deficiency would modulate DGW action...
September 20, 2016: Nutritional Neuroscience
Veerappan Venkatesh Gobi, Srinivasagam Rajasankar, Muthu Ramkumar, Chinnasamy Dhanalakshmi, Thamilarasan Manivasagam, Arokiasamy Justin Thenmozhi, Musthafa Mohamed Essa, Ranganathan Chidambaram
The present study was aimed to find out the effect of Agaricus blazei mushroom extract against rotenone-induced cellular model. SH-SY5Y neuroblastoma cells are divided into four experimental groups (control, rotenone (100 nM), A. blazei (5 μg/ml) + rotenone (100 nM), and A. blazei alone treated) based on MTT assay, cells were allowed to measure the ROS, TBARS levels, and antioxidants activities. Finally, mitochondrial transmembrane potential (MMP) and expressions of apoptotic proteins were also analyzed...
September 20, 2016: Nutritional Neuroscience
Youssef Bahbiti, Hammou Ammouri, Inssaf Berkiks, Aboubaker El Hessni, Ali Ouichou, Redouan Nakache, Miloud Chakit, Leila Bikjdaouene, Abdelhalem Mesfioui
Argan oil (AO) is rich in oleic and linoleic acids, polyphenols, sterols, and tocopherols. This composition gives it numerous beneficial pharmacological effects such as hypolipemiant, hypotensive, and antiproliferative. Oxidative stress is a mechanism of cell death induced by seizures and status epilepticus (SE). This study aims at investigating AO effects on (i) latency to first seizure, seizure severity, weight loss, mortality rate, (ii) lipid peroxidation level, nitrite level, and catalase activity in the hippocampus after SE induced by pilocarpine (PC)...
September 12, 2016: Nutritional Neuroscience
Itziar Abete, Maria Angeles Zulet, Estíbaliz Goyenechea, Vanessa Blazquez, Ana Maria de Arce Borda, Adolfo Lopez de Munain, J Alfredo Martinez
BACKGROUND: Lifestyle, including dietary patterns, could involve specific factors participating in inflammation that confer a higher risk of suffering a stroke. However, little attention has been apparently given to habitual food consumption in patients suffering a cerebrovascular event. OBJECTIVE: To assess the influence of dietary habits as well as other lifestyle-related variables on the risk of suffering a stroke. DESIGN: A case-control study was designed...
September 7, 2016: Nutritional Neuroscience
David S Liebeskind, Nerses Sanossian, Katherine A Fu, He-Jing Wang, Lenore Arab
OBJECTIVE: To determine the association in amount of daily coffee consumption with incidence of stroke in a broad cohort, considering other vascular risk factors. METHODS: We utilized the Third National Health and Nutrition Examination Survey (1988-1994; NHANES III) data on participants aged ≥17 years old to examine coffee consumption and stroke. Multivariate logistic regression models related the amount of coffee use reported in a food frequency questionnaire with stroke, controlling for other vascular risk factors...
November 2016: Nutritional Neuroscience
Salvador Marí-Bauset, Agustín Llopis-González, Itziar Zazpe, Amelia Marí-Sanchis, María Morales Suárez-Varela
OBJECTIVE: Children with autism spectrum disorder (ASD) have been found to have alterations in dietary fat intake and fat quality. The fat intakes of the foods consumed by children with and without ASD were compared, and the deficiency and excess of these nutrients were examined. METHODS: In a matched case-control study, 3-day food diaries were completed by 105 children with ASD and 495 typically developing (TD) 6- to 9-year-old children in Valencia (Spain). We used the probabilistic approach and estimated average requirement cut-point to evaluate the risk of inadequate nutrients intakes...
November 2016: Nutritional Neuroscience
Pramod Kumar Singh, Rajendra Nath, Mohammad Kaleem Ahmad, Akash Rawat, Suresh Babu, Rakesh Kumar Dixit
BACKGROUND: Among various types of polyunsaturated fatty acid (PUFA), omega-3 fatty acids play a crucial role in development and function of the brain. This study was undertaken to investigate the possible neuroprotective efficacy of omega-3 fatty acid on lead-induced neurotoxicity in rats. MATERIAL AND METHODS: The experiment was carried out on 32 male Wistar rats divided into four groups. The first group (control) was treated with distilled water and second group with lead acetate at the doses of 3 mg/kg b...
November 2016: Nutritional Neuroscience
Ali Akbar Mohammadi, Shima Jazayeri, Kianoush Khosravi-Darani, Zahra Solati, Nakisa Mohammadpour, Zatollah Asemi, Zohre Adab, Mahmoud Djalali, Mehdi Tehrani-Doost, Mostafa Hosseini, Shahryar Eghtesadi
OBJECTIVE: The aim of this study was to determine effects of probiotic yogurt and multispecies probiotic capsule supplementation on mental health and hypothalamic-pituitary-adrenal axis in petrochemical workers. METHODS: The present randomized double-blind, placebo-controlled trial was conducted on 70 petrochemical workers. Subjects were randomly divided into three groups to receive 100 g/day probiotic yogurt + one placebo capsule (n = 25) or one probiotic capsule daily + 100 g/day conventional yogurt (n = 25) or 100 g/day conventional yogurt + one placebo capsule (n = 20) for 6 weeks...
November 2016: Nutritional Neuroscience
B Carrillo, P Collado, F Díaz, J A Chowen, H Pinos
OBJECTIVES: Undernutrition during development alters the expression of peptides that control energy expenditure and feeding behavior. Estrogens can also modulate these peptides. Here, we analyze whether the early postnatal administration of estradiol modulates the effects of undernutrition on neuroendocrine parameters in adult female Wistar rats. METHODS: Control rats were fed a control diet. Undernourished pups were submitted to a restricted diet with half of the undernourished rats receiving 0...
November 2016: Nutritional Neuroscience
Katherine Caldwell, Karen Elizabeth Charlton, Steven Roodenrys, Andrew Jenner
No abstract text is available yet for this article.
November 2016: Nutritional Neuroscience
Byron C Jones
No abstract text is available yet for this article.
September 2016: Nutritional Neuroscience
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