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Nutritional Neuroscience

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https://www.readbyqxmd.com/read/29788823/synbiotic-supplementation-systemic-inflammation-and-symptoms-of-brain-disorders-in-elders-a-secondary-study-from-a-randomized-clinical-trial
#1
Eliana Regina Louzada, Sandra Maria Lima Ribeiro
OBJECTIVES: We aimed to investigate the effect of a symbiotic substance on symptoms of brain disorders and inflammation in the elderly. METHODS: Forty-nine elders, both genders, assigned into two groups: S-group (synbiotic) and P-group (placebo). Evaluations at the beginning and at the end of the experiment: geriatric depressive symptoms scale-15 (GDS-15); mini-mental status examination (MMSE); % of body fat (%fat); serum IL-6, TNF-α and IL-10; serum diamine-oxidase (DAO), intestinal fatty-acid binding protein (IFABP), and lipopolysaccharide (LPS)...
May 23, 2018: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29781405/changes-of-hippocampus-proteomic-profiles-after-blueberry-extracts-supplementation-in-app-ps1-transgenic-mice
#2
Hai-Qiang Li, Long Tan, Hong-Peng Yang, Wei Pang, Tong Xu, Yu-Gang Jiang
OBJECTIVE: To examine protein changes in the hippocampus of APP/PS1 transgenic mice after blueberry extracts (BB) intervention. METHODS: Eight APP/PS1 transgenic mice were randomly assigned to Alzheimer's disease (AD)+BB group (n=4) and AD+control group (n=4). After a 16-week treatment, 2-DE and MALDI-TOF-MS were used to compare the proteomic profiles of the hippocampus in the two groups and Western blot was used to confirm the important differentially expressed proteins...
May 21, 2018: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29756544/influence-of-malnutrition-on-the-development-of-the-central-nervous-system-of-malnourished-children
#3
Rosimar Costa Penido, Myriam Lima Isaac, Alexandre Batista Penido
INTRODUCTION: Protein-caloric malnutrition is a public health concern in certain areas of the Brazil. It can affect growth, the auditory nervous system development and, consequently, the cognition. This study compared the Brainstem Auditory Evoked Potential (BAEP) between malnourished and eutrophic children. METHODS: A total of 111 children, aged 0-60 months, were examined: 57 were malnourished, according to the World Health Organization criteria, and 54 were normo-nourished...
May 14, 2018: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29734917/body-composition-in-spinocerebellar-ataxia-type-3-and-10-patients-comparative-study-with-control-group
#4
Christiane de M B Almeida Leite, Maria Eliana M Schieferdecker, Caroline Frehner, Renato P Munhoz, Tetsuo Ashizawa, Hélio A G Teive
BACKGROUND: Spinocerebellar ataxias (SCAs) are a group of neurodegenerative genetic diseases characterized by movement disorders that can affect nutritional status and body composition. This study sought to assess body composition in SCA3 and SCA10 patients. METHODS: Anthropometric assessments and bioelectric impedance analysis were performed in 46 SCA3 and SCA10 patients and 76 controls of both genders. RESULTS: Of the patients, 69.6% had SCA3 and 58...
May 7, 2018: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29734883/is-transcranial-direct-current-stimulation-an-effective-modality-in-reducing-food-craving-a-systematic-review-and-meta-analysis
#5
Seyed-Ali Mostafavi, Ali Khaleghi, Mohammad Reza Mohammadi, Shahin Akhondzadeh
Non-invasive electrical stimulation of the brain has recently been extensively investigated to regulate food craving. However, the existing literature is controversial and there are some important questions which need to be addressed about clinical and technical factors contributing to efficacy of this method. A systematic search was performed in reliable scientific databases, and 15 eligible studies were identified. The pooled standardized mean differences for the effects of transcranial direct current stimulation (tDCS) on Visual Analogue Scale, energy intake and food craving questionnaire were -0...
May 7, 2018: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29733259/alcohol-consumption-in-meni%C3%A3-re-s-disease-patients
#6
Inés Sánchez-Sellero, Elena San-Román-Rodríguez, Sofía Santos-Pérez, Marcos Rossi-Izquierdo, Andrés Soto-Varela
OBJECTIVES: Dietary changes are useful in the management of Menière's disease; regarding alcohol, many clinicians recommend to avoid or reduce its consumption. However, there are no researches aimed to evaluate whether habitual alcohol consumption is more prevalent and/or more intense in patients with Menière's disease. METHODS: Cross-sectional, observational, case-control study, including three groups: patients with Menière's disease, patients with vertigo of other origins, and control subjects...
May 7, 2018: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29730972/the-protective-effect-of-extra-virgin-olive-oil-in-the-experimental-model-of-multiple-sclerosis-in-the-rat
#7
C Conde, B M Escribano, E Luque, M Aguilar-Luque, M Feijóo, J J Ochoa, M LaTorre, A I Giraldo, R Lillo, E Agüera, A Santamaría, I Túnez
This study has evaluated the effect of EVOO (Extra-Virgin olive oil), OA (oleic acid) and HT (hydroxytyrosol) in an induced model of MS through experimental autoimmune encephalomyelitis (EAE). Dark Agouti 2-month old rats (25 males) were divided into five groups: (i) control group, (ii) EAE group, (iii) EAE+EVOO, (iv) EAE+HT, and (v) EAE+OA. At 65 days, the animals were sacrificed and the glutathione redox system and bacterial lipopolysaccharide (LPS) and LPS-binding protein (LBP) products of the microbiota in brain, spinal cord, and blood were evaluated...
May 5, 2018: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29712539/the-ethanolic-extract-obtained-from-campomanesia-pubescens-d-c-o-berg-fruits-exerts-anxiolytic-and-antidepressant-effects-on-chronic-mild-stress-model-and-on-anxiety-models-in-wistar-rats-behavioral-evidences
#8
Gustavo Roberto Villas Boas, Ana Paula Stefanello da Silveira, Brunna Charlla Feitosa Farinelli, Claudia Andréa Lima Cardoso, Emely Arce, Silvia Aparecida Oesterreich
OBJECTIVES: Campomanesia pubescens (DC) O.BERG (Myrtaceae) fruits contain high levels of flavonoids and are widely consumed by the South American population. In the central nervous system (CNS), some flavonoids act as modulators of GABA-A receptors and monoamine oxidase inhibitors, resulting in anxiolytic antidepressants effects, respectively. The objective of the present study was to evaluate the anxiolytic and antidepressant effects of ethanolic extract of C. pubescens fruits (EEFCP) in rats...
May 1, 2018: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29712510/modulation-of-brain-insulin-signaling-in-alzheimer-s-disease-new-insight-on-the-protective-role-of-green-coffee-bean-extract
#9
Hoda E Mohamed, Mervat E Asker, Nahla N Younis, Mohamed A Shaheen, Rana G Eissa
OBJECTIVE: Alzheimer's disease (AD), a neurodegenerative disorder, involves brain insulin signaling cascades and insulin resistance (IR). Because of limited treatment options, new treatment strategies are mandatory. Green coffee bean extract (GCBE) was reported to attenuate IR and improve brain energy metabolism. We aimed to investigate the possible use of GCBE as a prophylactic strategy to delay the onset of AD or combined with pioglitazone (PIO) as a strategy to retard the progression of AD...
May 1, 2018: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29697017/high-fat-diet-induces-depression-like-behaviour-in-mice-associated-with-changes-in-microbiome-neuropeptide-y-and-brain-metabolome
#10
Ahmed M Hassan, Giulia Mancano, Karl Kashofer, Esther E Fröhlich, Andrija Matak, Raphaela Mayerhofer, Florian Reichmann, Marta Olivares, Audrey M Neyrinck, Nathalie M Delzenne, Sandrine P Claus, Peter Holzer
OBJECTIVES: The biological mechanisms linking diet-related obesity and depression remain unclear. Therefore, we examined the impact of high-fat diet (HFD) on murine behaviour, intestinal microbiome, brain metabolome, neuropeptide Y (NPY) expression, and dipeptidyl peptidase-4 (DPP-4) activity. METHODS: Male C57Bl/6J mice were fed an HFD (60 kJ% from fat) or control diet (12 kJ% from fat) for 8 weeks, followed by behavioural phenotyping. Caecal microbiome was analysed by 16S rDNA sequencing, brain metabolome by 1 H nuclear magnetic resonance, NPY expression by PCR and immunoassay, and dipeptidyl peptidase-4 (DPP-4) activity by enzymatic assay...
April 26, 2018: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29690822/association-between-macronutrient-intake-and-amyotrophic-lateral-sclerosis-prognosis
#11
Boeun Kim, Youri Jin, Seung Hyun Kim, Yongsoon Park
OBJECTIVES: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease, and the nutritional state of ALS patients is associated with survival. The purpose of the present study was to investigate whether macronutrient intake at early stage of the disease was positively associated with survival and duration from symptom onset to death, tracheostomy, or non-invasive ventilation (NIV) in ALS. METHODS: ALS patients diagnosed according to EI Escorial criteria were recruited from 2011 to 2016 and followed up until 2017, when they reached the endpoint of death, tracheostomy, or NIV use...
April 24, 2018: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29669486/diet-the-keystone-of-autism-spectrum-disorder
#12
S Peretti, M Mariano, C Mazzocchetti, M Mazza, M C Pino, A Verrotti Di Pianella, M Valenti
Children with autism are characterized by an impairment of social interaction and repetitive patterns of behaviour. Autism is a heterogeneous span of disorders with unknown aetiology. Research has grown significantly and has suggested that environmental risk factors acting during the prenatal period could influence the neurodevelopment of offspring. The literature suggests that the maternal diet during pregnancy has a fundamental role in the etiopathogenesis of autism. Indeed, a maternal diet that is high in some nutrients has been associated with an increase or reduction in the risk of develop Autism Spectrum Disorders (ASD)...
April 19, 2018: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29649949/postprandial-effects-of-breakfast-glycaemic-index-on-cognitive-performance-among-young-healthy-adults-a-crossover-clinical-trial
#13
Natalia Sanchez-Aguadero, Jose I Recio-Rodriguez, Maria C Patino-Alonso, Sara Mora-Simon, Rosario Alonso-Dominguez, Benigna Sanchez-Salgado, Manuel A Gomez-Marcos, Luis Garcia-Ortiz
OBJECTIVE: To evaluate the postprandial effects of high and low glycaemic index (GI) breakfasts on cognitive performance in young, healthy adults. METHODS: A crossover clinical trial including 40 young, healthy adults (aged 20-40 years, 50% females) recruited from primary healthcare centres in Salamanca, Spain. Verbal memory, phonological fluency, attention, and executive functions were examined 0, 60, and 120 minutes after consuming a low GI (LGI), high GI (HGI), or water breakfast...
April 12, 2018: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29642764/distinct-effects-of-resveratrol-on-seizures-and-hyperexcitability-induced-by-nmda-and-4-aminopyridine
#14
Ya-Jean Wang, Chung-Pin Hsieh, Ming-Huan Chan, Tzu-Yi Chan, Linyi Chen, Hwei-Hisen Chen
OBJECTIVES: The antiepileptic activity of resveratrol has been revealed in various experimental models of epilepsy. The present study evaluated the effects of resveratrol on the seizures and hyperexcitable neuronal activity associated with activation of N-methyl-d-aspartic acid (NMDA) receptor and inhibition of voltage-gated potassium channels. METHODS: The effects of resveratrol on seizure thresholds, excitatory field potentials (EFPs) and action potentials induced by NMDA and 4-aminopyridine (4-AP) were monitored in mice, the mouse cortical slices and rat cortical neurons, respectively...
April 12, 2018: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29629638/fluctuations-in-clinical-symptoms-with-changes-in-serum-25-oh-vitamin-d-levels-in-autistic-children-three-cases-report
#15
Feiyong Jia, Ling Shan, Bing Wang, Honghua Li, Junyan Feng, Zhida Xu, Khaled Saad
Autism spectrum disorder (ASD) is a common neurodevelopmental disorder caused by complicated interactions between genetic and environmental factors. Clinical trials, including case reports, case-control studies, and a double-blinded randomized clinical study, have suggested that high-dose vitamin D3 regimens may ameliorate the core symptoms of ASD. Vitamin D3 supplementation was effective in about three-quarters of children with ASD. To further investigate the relationship between vitamin D and ASD symptoms in vitamin D-responsive autistic children, changes in symptoms were assessed in three children with ASD who were given vitamin D3 supplementation followed by a long interruption...
April 8, 2018: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29607741/intragastric-quinine-administration-decreases-hedonic-eating-in-healthy-women-through-peptide-mediated-gut-brain-signaling-mechanisms
#16
Julie Iven, Jessica R Biesiekierski, Dongxing Zhao, Eveline Deloose, Owen G O'Daly, Inge Depoortere, Jan Tack, Lukas Van Oudenhove
OBJECTIVES: Intragastric bitter tastants may decrease appetite and food intake. We aimed to investigate the gut-brain signaling and brain mechanisms underlying these effects. METHODS: Brain responses to intragastric quinine-hydrochloride (QHCl, 10 µmol/kg) or placebo infusion were recorded using functional magnetic resonance imaging in 15 healthy women. Appetite-related sensations, plasma levels of gastrointestinal hormones and hedonic food intake (ad libitum drink test) were assessed...
April 2, 2018: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29595091/neuroprotective-effect-of-tempeh-against-lipopolysaccharide-induced-damage-in-bv-2-microglial-cells
#17
Juen-Haur Hwang, Shu-Jing Wu, Po-Long Wu, Yong-Yao Shih, Yin-Ching Chan
OBJECTIVES: This study evaluated the bioactive composition of tempeh products and examined the effects of tempeh on BV-2 microglial cell cytotoxicity, neurotrophic effects, and expression of inflammatory genes. METHODS: Tempeh products included soybean fermented by Rhizopus, soybean fermented through cocultivation with Rhizopus and Lactobacillus, and red bean fermented through cocultivation with Rhizopus and Lactobacillus (RT-C). We analyzed the bioactive contents of tempeh extracts and evaluated the effects of tempeh water extract on lipopolysaccharide (LPS)-treated BV-2 cells...
March 29, 2018: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29534651/maternal-caffeine-intake-in-pregnancy-is-inversely-related-to-childhood-peer-problems-in-japan-the-kyushu-okinawa-maternal-and-child-health-study
#18
Yoshihiro Miyake, Keiko Tanaka, Hitomi Okubo, Satoshi Sasaki, Masashi Arakawa
OBJECTIVES: The present prebirth cohort study examined the association between maternal caffeine consumption during pregnancy and behavioral problems in Japanese children aged 5 years. METHODS: Subjects were 1199 mother-child pairs. Dietary intake was assessed using a diet history questionnaire. Emotional problems, conduct problems, hyperactivity problems, and peer problems were assessed using the Japanese parent-report version of the Strengths and Difficulties Questionnaire...
March 13, 2018: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29527960/caffeine-and-energy-drink-use-by-combat-arms-soldiers-in-afghanistan-as-a-countermeasure-for-sleep-loss-and-high-operational-demands
#19
Tom M McLellan, Lyndon A Riviere, Kelly W Williams, Dennis McGurk, Harris R Lieberman
OBJECTIVES: Combat deployments are characterized by high operational demands with limited opportunities for sleep leading to fatigue and degraded cognitive and operational performance. Caffeine in moderate doses is recognized as an effective intervention for physical and cognitive decrements associated with sleep loss. METHODS: This report is based on data collected by two separate, independently conducted surveys administered in Afghanistan in 2011-2012. It assessed caffeine use and sleep disruption among U...
March 11, 2018: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29514592/effects-of-isoflavones-on-behavior-estradiol-glutamate-and-gaba-levels-in-intact-middle-aged-female-rats
#20
Thaísa Meira Sandini, Thiago Marinho Reis-Silva, Natalia Moreira, Maria Martha Bernardi, Ivo Lebrun, Helenice de Souza Spinosa
OBJECTIVES: Estrogen and phytoestrogens, mainly isoflavones (SIF) treatment has been suggested to improve mood, behavior, and cognitive function in postmenopausal women. However, there is a lack of information on the mechanism of such treatment on the central nervous system. We used rats to investigate the effects of long-term treatment with commercial isoflavones on behavior, hormones, and brain neurotransmitter levels. METHODS: Intact female middle-aged (12 months) rats received 50, 100, and 200 mg/kg/day of commercial isoflavones extract by gavage for 90 days...
March 7, 2018: Nutritional Neuroscience
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