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Nature Cell Biology

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https://www.readbyqxmd.com/read/30224762/metabolic-control-of-ferroptosis-in-cancer
#1
Michael P Murphy
No abstract text is available yet for this article.
September 17, 2018: Nature Cell Biology
https://www.readbyqxmd.com/read/30224761/life-death-and-autophagy
#2
REVIEW
Johnna Doherty, Eric H Baehrecke
Autophagy influences cell survival through maintenance of cell bioenergetics and clearance of protein aggregates and damaged organelles. Several lines of evidence indicate that autophagy is a multifaceted regulator of cell death, but controversy exists over whether autophagy alone can drive cell death under physiologically relevant circumstances. Here, we review the role of autophagy in cell death and examine how autophagy interfaces with other forms of cell death including apoptosis and necrosis.
September 17, 2018: Nature Cell Biology
https://www.readbyqxmd.com/read/30224760/single-particle-trajectories-reveal-active-endoplasmic-reticulum-luminal-flow
#3
David Holcman, Pierre Parutto, Joseph E Chambers, Marcus Fantham, Laurence J Young, Stefan J Marciniak, Clemens F Kaminski, David Ron, Edward Avezov
The endoplasmic reticulum (ER), a network of membranous sheets and pipes, supports functions encompassing biogenesis of secretory proteins and delivery of functional solutes throughout the cell1,2 . Molecular mobility through the ER network enables these functionalities, but diffusion alone is not sufficient to explain luminal transport across supramicrometre distances. Understanding the ER structure-function relationship is critical in light of mutations in ER morphology-regulating proteins that give rise to neurodegenerative disorders3,4 ...
September 17, 2018: Nature Cell Biology
https://www.readbyqxmd.com/read/30224759/lncgata6-maintains-stemness-of-intestinal-stem-cells-and-promotes-intestinal-tumorigenesis
#4
Pingping Zhu, Jiayi Wu, Yanying Wang, Xiaoxiao Zhu, Tiankun Lu, Benyu Liu, Luyun He, Buqing Ye, Shuo Wang, Shu Meng, Dongdong Fan, Jing Wang, Liuliu Yang, Xiwen Qin, Ying Du, Chong Li, Lei He, Weizheng Ren, Xin Wu, Yong Tian, Zusen Fan
The intestinal epithelium harbours remarkable self-renewal capacity that is driven by Lgr5+ intestinal stem cells (ISCs) at the crypt base. However, the molecular mechanism controlling Lgr5+ ISC stemness is incompletely understood. We show that a Gata6 long noncoding RNA (lncGata6) is highly expressed in ISCs. LncGata6 knockout or conditional knockout in ISCs impairs the stemness of ISCs and epithelial regeneration. Mechanistically, lncGata6 recruits the NURF complex onto the Ehf promoter to induce its transcription, which promotes the expression of Lgr4/5 to enhance Wnt signalling activation...
September 17, 2018: Nature Cell Biology
https://www.readbyqxmd.com/read/30218017/retraction-note-formin-a-perinuclear-actin-cage-in-confined-migration
#5
Alexia-Ileana Zaromytidou
Given that the authors of 'FMN2 makes perinuclear actin to protect nuclei during confined migration and promote metastasis' (Skau et al. Cell 167, 1571-1585; 2016) have retracted their paper, I wish to retract this Research Highlight, which discussed the findings reported in that study.
September 14, 2018: Nature Cell Biology
https://www.readbyqxmd.com/read/30202051/polarized-microtubule-dynamics-directs-cell-mechanics-and-coordinates-forces-during-epithelial-morphogenesis
#6
Amrita Singh, Tanumoy Saha, Isabell Begemann, Andrea Ricker, Harald Nüsse, Oliver Thorn-Seshold, Jürgen Klingauf, Milos Galic, Maja Matis
Coordinated rearrangements of cytoskeletal structures are the principal source of forces that govern cell and tissue morphogenesis1,2 . However, unlike for actin-based mechanical forces, our knowledge about the contribution of forces originating from other cytoskeletal components remains scarce. Here, we establish microtubules as central components of cell mechanics during tissue morphogenesis. We find that individual cells are mechanically autonomous during early Drosophila wing epithelium development. Each cell contains a polarized apical non-centrosomal microtubule cytoskeleton that bears compressive forces, whereby acute elimination of microtubule-based forces leads to cell shortening...
September 10, 2018: Nature Cell Biology
https://www.readbyqxmd.com/read/30202050/a-tension-mediated-glycocalyx-integrin-feedback-loop-promotes-mesenchymal-like-glioblastoma
#7
J Matthew Barnes, Shelly Kaushik, Russell O Bainer, Jason K Sa, Elliot C Woods, FuiBoon Kai, Laralynne Przybyla, Mijeong Lee, Hye Won Lee, Jason C Tung, Ori Maller, Alexander S Barrett, Kan V Lu, Jonathon N Lakins, Kirk C Hansen, Kirsten Obernier, Arturo Alvarez-Buylla, Gabriele Bergers, Joanna J Phillips, Do-Hyun Nam, Carolyn R Bertozzi, Valerie M Weaver
Glioblastoma multiforme (GBMs) are recurrent lethal brain tumours. Recurrent GBMs often exhibit mesenchymal, stem-like phenotypes that could explain their resistance to therapy. Analyses revealed that recurrent GBMs have increased tension and express high levels of glycoproteins that increase the bulkiness of the glycocalyx. Studies showed that a bulky glycocalyx potentiates integrin mechanosignalling and tissue tension and promotes a mesenchymal, stem-like phenotype in GBMs. Gain- and loss-of-function studies implicated integrin mechanosignalling as an inducer of GBM growth, survival, invasion and treatment resistance, and a mesenchymal, stem-like phenotype...
September 10, 2018: Nature Cell Biology
https://www.readbyqxmd.com/read/30202049/bap1-links-metabolic-regulation-of-ferroptosis-to-tumour-suppression
#8
Yilei Zhang, Jiejun Shi, Xiaoguang Liu, Li Feng, Zihua Gong, Pranavi Koppula, Kapil Sirohi, Xu Li, Yongkun Wei, Hyemin Lee, Li Zhuang, Gang Chen, Zhen-Dong Xiao, Mien-Chie Hung, Junjie Chen, Peng Huang, Wei Li, Boyi Gan
The roles and regulatory mechanisms of ferroptosis (a non-apoptotic form of cell death) in cancer remain unclear. The tumour suppressor BRCA1-associated protein 1 (BAP1) encodes a nuclear deubiquitinating enzyme to reduce histone 2A ubiquitination (H2Aub) on chromatin. Here, integrated transcriptomic, epigenomic and cancer genomic analyses link BAP1 to metabolism-related biological processes, and identify cystine transporter SLC7A11 as a key BAP1 target gene in human cancers. Functional studies reveal that BAP1 decreases H2Aub occupancy on the SLC7A11 promoter and represses SLC7A11 expression in a deubiquitinating-dependent manner, and that BAP1 inhibits cystine uptake by repressing SLC7A11 expression, leading to elevated lipid peroxidation and ferroptosis...
September 10, 2018: Nature Cell Biology
https://www.readbyqxmd.com/read/30190576/author-correction-amp-kinase-promotes-glioblastoma-bioenergetics-and-tumour-growth
#9
Rishi Raj Chhipa, Qiang Fan, Jane Anderson, Ranjithmenon Muraleedharan, Yan Huang, Georgianne Ciraolo, Xiaoting Chen, Ronald Waclaw, Lionel M Chow, Zaza Khuchua, Matthew Kofron, Matthew T Weirauch, Ady Kendler, Christopher McPherson, Nancy Ratner, Ichiro Nakano, Nupur Dasgupta, Kakajan Komurov, Biplab Dasgupta
In the version of this Article originally published, in ref. 34 the first author's name was spelled incorrectly. The correct reference is: Rodón, L. et al. Active CREB1 promotes a malignant TGFβ2 autocrine loop in glioblastoma. Cancer Discov. 10, 1230-1241 (2014). This has now been amended in all online versions of the Article.
September 6, 2018: Nature Cell Biology
https://www.readbyqxmd.com/read/30181621/author-correction-topoisomerase-ii%C3%AE-controls-the-decatenation-checkpoint
#10
Kuntian Luo, Jian Yuan, Junjie Chen, Zhenkun Lou
In Fig. 1b of this Article, the authors mistakenly republished a blot previously published as Fig. 1d in their article in Nature Structural & Molecular Biology (Nat. Struct. Mol. Biol. 12, 589-593; 2005).
September 4, 2018: Nature Cell Biology
https://www.readbyqxmd.com/read/30177776/stem-cell-functionality-is-microenvironmentally-defined-during-tumour-expansion-and-therapy-response-in-colon-cancer
#11
Kristiaan J Lenos, Daniël M Miedema, Sophie C Lodestijn, Lisanne E Nijman, Tom van den Bosch, Xavier Romero Ros, Filipe C Lourenço, Maria C Lecca, Maartje van der Heijden, Sanne M van Neerven, Anita van Oort, Nicolas Leveille, Ronja S Adam, Felipe de Sousa E Melo, Joy Otten, Patrick Veerman, Guillaume Hypolite, Lianne Koens, Scott K Lyons, Giorgio Stassi, Douglas J Winton, Jan Paul Medema, Edward Morrissey, Maarten F Bijlsma, Louis Vermeulen
Solid malignancies have been speculated to depend on cancer stem cells (CSCs) for expansion and relapse after therapy. Here we report on quantitative analyses of lineage tracing data from primary colon cancer xenograft tissue to assess CSC functionality in a human solid malignancy. The temporally obtained clone size distribution data support a model in which stem cell function in established cancers is not intrinsically, but is entirely spatiotemporally orchestrated. Functional stem cells that drive tumour expansion predominantly reside at the tumour edge, close to cancer-associated fibroblasts...
September 3, 2018: Nature Cell Biology
https://www.readbyqxmd.com/read/30127497/publisher-correction-fbp17-and-cip4-recruit-ship2-and-lamellipodin-to-prime-the-plasma-membrane-for-fast-endophilin-mediated-endocytosis
#12
Laura Chan Wah Hak, Shaheen Khan, Ilaria Di Meglio, Ah-Lai Law, Safa Lucken-Ardjomande Häsler, Leonor M Quintaneiro, Antonio P A Ferreira, Matthias Krause, Harvey T McMahon, Emmanuel Boucrot
In the version of this Letter originally published, the name of co-author Safa Lucken-Ardjomande Häsler was coded wrongly, resulting in it being incorrect when exported to citation databases. This has been corrected, though no visible changes will be apparent.
August 20, 2018: Nature Cell Biology
https://www.readbyqxmd.com/read/30089844/publisher-correction-self-assembly-of-embryonic-and-two-extra-embryonic-stem-cell-types-into-gastrulating-embryo-like-structures
#13
Berna Sozen, Gianluca Amadei, Andy Cox, Ran Wang, Ellen Na, Sylwia Czukiewska, Lia Chappell, Thierry Voet, Geert Michel, Naihe Jing, David M Glover, Magdalena Zernicka-Goetz
In the version of this Technical Report originally published, the competing interests statement was missing. The authors declare no competing interests; this statement has now been added in all online versions of the Report.
August 8, 2018: Nature Cell Biology
https://www.readbyqxmd.com/read/30089843/publisher-correction-ire1%C3%AE-governs-cytoskeleton-remodelling-and-cell-migration-through-a-direct-interaction-with-filamin-a
#14
Hery Urra, Daniel R Henriquez, José Cánovas, David Villarroel-Campos, Amado Carreras-Sureda, Eduardo Pulgar, Emiliano Molina, Younis M Hazari, Celia M Limia, Sebastián Alvarez-Rojas, Ricardo Figueroa, Rene L Vidal, Diego A Rodriguez, Claudia A Rivera, Felipe A Court, Andrés Couve, Ling Qi, Eric Chevet, Ryoko Akai, Takao Iwawaki, Miguel L Concha, Álvaro Glavic, Christian Gonzalez-Billault, Claudio Hetz
In the version of this Article originally published, the competing interests statement was missing. The authors declare no competing interests; this statement has now been added in all online versions of the Article.
August 8, 2018: Nature Cell Biology
https://www.readbyqxmd.com/read/30089842/publisher-correction-aspartate-is-a-limiting-metabolite-for-cancer-cell-proliferation-under-hypoxia-and-in-tumours
#15
Javier Garcia-Bermudez, Lou Baudrier, Konnor La, Xiphias Ge Zhu, Justine Fidelin, Vladislav O Sviderskiy, Thales Papagiannakopoulos, Henrik Molina, Matija Snuderl, Caroline A Lewis, Richard L Possemato, Kıvanç Birsoy
In the version of this Letter originally published, the competing interests statement was missing. The authors declare no competing interests; this statement has now been added in all online versions of the Letter.
August 8, 2018: Nature Cell Biology
https://www.readbyqxmd.com/read/30089841/publisher-correction-amp-kinase-promotes-glioblastoma-bioenergetics-and-tumour-growth
#16
Rishi Raj Chhipa, Qiang Fan, Jane Anderson, Ranjithmenon Muraleedharan, Yan Huang, Georgianne Ciraolo, Xiaoting Chen, Ronald Waclaw, Lionel M Chow, Zaza Khuchua, Matthew Kofron, Matthew T Weirauch, Ady Kendler, Christopher McPherson, Nancy Ratner, Ichiro Nakano, Nupur Dasgupta, Kakajan Komurov, Biplab Dasgupta
In the version of this Article originally published, the competing interests statement was missing. The authors declare no competing interests; this statement has now been added in all online versions of the Article.
August 8, 2018: Nature Cell Biology
https://www.readbyqxmd.com/read/30038257/publisher-correction-tracing-the-temporal-spatial-transcriptome-landscapes-of-the-human-fetal-digestive-tract-using-single-cell-rna-sequencing
#17
Shuai Gao, Liying Yan, Rui Wang, Jingyun Li, Jun Yong, Xin Zhou, Yuan Wei, Xinglong Wu, Xiaoye Wang, Xiaoying Fan, Jie Yan, Xu Zhi, Yun Gao, Hongshan Guo, Xiao Jin, Wendong Wang, Yunuo Mao, Fengchao Wang, Lu Wen, Wei Fu, Hao Ge, Jie Qiao, Fuchou Tang
In the PDF version of this Resource originally published, on the author list the superscript number 9 to indicate Rui Wang was an equally contributing author was missing owing to a technical error. This has now been amended. In addition, the authors wish to replace Supplementary Table 2, as in the original version Group 1 immune cells were mis-classified into Group 46 immune cells, resulting in three groups of immune cells where there should have been four. Supplementary Table 2 has now been replaced.
July 23, 2018: Nature Cell Biology
https://www.readbyqxmd.com/read/30022120/publisher-correction-single-cell-multi-omics-sequencing-of-human-early-embryos
#18
Lin Li, Fan Guo, Yun Gao, Yixin Ren, Peng Yuan, Liying Yan, Rong Li, Ying Lian, Jingyun Li, Boqiang Hu, Junpeng Gao, Lu Wen, Fuchou Tang, Jie Qiao
In the version of this Resource originally published, owing to a technical error an incorrect file was used for Supplementary Table 2; this has now been replaced with the correct file.
July 18, 2018: Nature Cell Biology
https://www.readbyqxmd.com/read/29991753/publisher-correction-mechanisms-and-impact-of-altered-tumour-mechanics
#19
Hamid Mohammadi, Erik Sahai
In the version of this Review originally published, owing to a technical error the text 'However, given the multitude' was incorrectly introduced after the sentence beginning 'The transition to a mesenchymal state is characterized...'. This has now been amended in all online versions of the Review.
July 10, 2018: Nature Cell Biology
https://www.readbyqxmd.com/read/30154567/mechanisms-of-mitophagy-in-cellular-homeostasis-physiology-and-pathology
#20
REVIEW
Konstantinos Palikaras, Eirini Lionaki, Nektarios Tavernarakis
Mitophagy is an evolutionarily conserved cellular process to remove dysfunctional or superfluous mitochondria, thus fine-tuning mitochondrial number and preserving energy metabolism. In this Review, we survey recent advances towards elucidating the molecular mechanisms that mediate mitochondrial elimination and the signalling pathways that govern mitophagy. We consider the contributions of mitophagy in physiological and pathological contexts and discuss emerging findings, highlighting the potential value of mitophagy modulation in therapeutic intervention...
September 2018: Nature Cell Biology
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