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Nature Cell Biology

J Paul Luzio
No abstract text is available yet for this article.
November 5, 2018: Nature Cell Biology
Brittany C Michel, Andrew R D'Avino, Seth H Cassel, Nazar Mashtalir, Zachary M McKenzie, Matthew J McBride, Alfredo M Valencia, Qianhe Zhou, Michael Bocker, Luis M M Soares, Joshua Pan, David I Remillard, Caleb A Lareau, Hayley J Zullow, Nora Fortoul, Nathanael S Gray, James E Bradner, Ho Man Chan, Cigall Kadoch
Mammalian SWI/SNF chromatin remodelling complexes exist in three distinct, final-form assemblies: canonical BAF (cBAF), PBAF and a newly characterized non-canonical complex (ncBAF). However, their complex-specific targeting on chromatin, functions and roles in disease remain largely undefined. Here, we comprehensively mapped complex assemblies on chromatin and found that ncBAF complexes uniquely localize to CTCF sites and promoters. We identified ncBAF subunits as synthetic lethal targets specific to synovial sarcoma and malignant rhabdoid tumours, which both exhibit cBAF complex (SMARCB1 subunit) perturbation...
November 5, 2018: Nature Cell Biology
Alberto di Ronza, Lakshya Bajaj, Jaiprakash Sharma, Deepthi Sanagasetti, Parisa Lotfi, Carolyn Joy Adamski, John Collette, Michela Palmieri, Abdallah Amawi, Lauren Popp, Kevin Tommy Chang, Maria Chiara Meschini, Hon-Chiu Eastwood Leung, Laura Segatori, Alessandro Simonati, Richard Norman Sifers, Filippo Maria Santorelli, Marco Sardiello
Organelle biogenesis requires proper transport of proteins from their site of synthesis to their target subcellular compartment1-3 . Lysosomal enzymes are synthesized in the endoplasmic reticulum (ER) and traffic through the Golgi complex before being transferred to the endolysosomal system4-6 , but how they are transferred from the ER to the Golgi is unknown. Here, we show that ER-to-Golgi transfer of lysosomal enzymes requires CLN8, an ER-associated membrane protein whose loss of function leads to the lysosomal storage disorder, neuronal ceroid lipofuscinosis 8 (a type of Batten disease)7 ...
November 5, 2018: Nature Cell Biology
Youn-Sang Jung, Sohee Jun, Moon Jong Kim, Sung Ho Lee, Han Na Suh, Esther M Lien, Hae-Yun Jung, Sunhye Lee, Jie Zhang, Jung-In Yang, Hong Ji, Ji Yuan Wu, Wenqi Wang, Rachel K Miller, Junjie Chen, Pierre D McCrea, Scott Kopetz, Jae-Il Park
Vesicular acidification and trafficking are associated with various cellular processes. However, their pathologic relevance to cancer remains elusive. We identified transmembrane protein 9 (TMEM9) as a vesicular acidification regulator. TMEM9 is highly upregulated in colorectal cancer. Proteomic and biochemical analyses show that TMEM9 binds to and facilitates assembly of vacuolar-ATPase (v-ATPase), a vacuolar proton pump, resulting in enhanced vesicular acidification and trafficking. TMEM9-v-ATPase hyperactivates Wnt/β-catenin signalling via lysosomal degradation of adenomatous polyposis coli (APC)...
October 29, 2018: Nature Cell Biology
Laura Chan Wah Hak, Shaheen Khan, Ilaria Di Meglio, Ah-Lai Law, Safa Lucken-Ardjomande Häsler, Leonor M Quintaneiro, Antonio P A Ferreira, Matthias Krause, Harvey T McMahon, Emmanuel Boucrot
In the version of this Letter originally published, the name of co-author Safa Lucken-Ardjomande Häsler was coded wrongly, resulting in it being incorrect when exported to citation databases. This has been corrected, though no visible changes will be apparent.
August 20, 2018: Nature Cell Biology
Erica T Goddard, Ivana Bozic, Stanley R Riddell, Cyrus M Ghajar
Despite increased focus on the clinical relevance of dormant metastatic disease, our understanding of dormant niches, mechanisms underlying emergence from dormancy, and the immune system's role in this phenomenon, remains in its infancy. Here, we discuss key work that has shaped our current understanding of these topics. Because tumour dormancy provides a unique therapeutic window to prevent metastatic disease, we discuss on-going clinical trials and weigh the potential for immunotherapy to eradicate dormant disease...
November 2018: Nature Cell Biology
Valentina Cigliola, Luiza Ghila, Fabrizio Thorel, Léon van Gurp, Delphine Baronnier, Daniel Oropeza, Simone Gupta, Takeshi Miyatsuka, Hideaki Kaneto, Mark A Magnuson, Anna B Osipovich, Maike Sander, Christopher E V Wright, Melissa K Thomas, Kenichiro Furuyama, Simona Chera, Pedro L Herrera
The mechanisms that restrict regeneration and maintain cell identity following injury are poorly characterized in higher vertebrates. Following β-cell loss, 1-2% of the glucagon-producing α-cells spontaneously engage in insulin production in mice. Here we explore the mechanisms inhibiting α-cell plasticity. We show that adaptive α-cell identity changes are constrained by intra-islet insulin- and Smoothened-mediated signalling, among others. The combination of β-cell loss or insulin-signalling inhibition, with Smoothened inactivation in α- or δ-cells, stimulates insulin production in more α-cells...
November 2018: Nature Cell Biology
(no author information available yet)
Science denial is not new but, in the digital age, evidence-based conclusions appear to be increasingly threatened by beliefs based on emotion and isolated personal experience. When confronting a post-truth world, scientists must defend the scientific method and increase public engagement.
November 2018: Nature Cell Biology
John G Lock, Matthew C Jones, Janet A Askari, Xiaowei Gong, Anna Oddone, Helene Olofsson, Sara Göransson, Melike Lakadamyali, Martin J Humphries, Staffan Strömblad
Adhesion to the extracellular matrix persists during mitosis in most cell types. However, while classical adhesion complexes, such as focal adhesions, do and must disassemble to enable mitotic rounding, the mechanisms of residual mitotic cell-extracellular matrix adhesion remain undefined. Here, we identify 'reticular adhesions', a class of adhesion complex that is mediated by integrin αvβ5, formed during interphase, and preserved at cell-extracellular matrix attachment sites throughout cell division. Consistent with this role, integrin β5 depletion perturbs mitosis and disrupts spatial memory transmission between cell generations...
November 2018: Nature Cell Biology
Ronen Zaidel-Bar
No abstract text is available yet for this article.
November 2018: Nature Cell Biology
Youn-Sang Jung, Wenqi Wang, Sohee Jun, Jie Zhang, Mrinal Srivastava, Moon Jong Kim, Esther M Lien, Joan Shang, Junjie Chen, Pierre D McCrea, Songlin Zhang, Jae-Il Park
Epithelial integrity is maintained by the cytoskeleton and through cell adhesion. However, it is not yet known how a deregulated cytoskeleton is associated with cancer. We identified cancer-related regulator of actin dynamics (CRAD) as frequently mutated or transcriptionally downregulated in colorectal cancer. We found that CRAD stabilizes the cadherin-catenin-actin complex via capping protein inhibition. The loss of CRAD inhibits F-actin polymerization and subsequently disrupts the cadherin-catenin-actin complex, which leads to β-catenin release and Wnt signalling hyperactivation...
November 2018: Nature Cell Biology
George Eng, Jonathan Braverman, Ömer H Yilmaz
No abstract text is available yet for this article.
November 2018: Nature Cell Biology
Zhe Ying, Madeline Sandoval, Slobodan Beronja
Oncogenic lesions are surprisingly common in morphologically and functionally normal human skin. However, the cellular and molecular mechanisms that suppress their cancer-driving potential to maintain tissue homeostasis are unknown. By employing assays for the direct and quantitative assessment of cell fate choices in vivo, we show that oncogenic activation of PI3K-AKT, the most commonly activated oncogenic pathway in cancer, promotes the differentiation and cell cycle exit of epidermal progenitors. As a result, oncogenic PI3K-AKT-activated epidermis exhibits a growth disadvantage even though its cells are more proliferative...
November 2018: Nature Cell Biology
Paola Kuri, Panteleimon Rompolas
No abstract text is available yet for this article.
November 2018: Nature Cell Biology
Neophytos Christodoulou, Christos Kyprianou, Antonia Weberling, Ran Wang, Guizhong Cui, Guangdum Peng, Naihe Jing, Magdalena Zernicka-Goetz
The morphogenetic remodelling of embryo architecture after implantation culminates in pro-amniotic cavity formation. Despite its key importance, how this transformation occurs remains unknown. Here, we apply high-resolution imaging of embryos developing in vivo and in vitro, spatial RNA sequencing and 3D trophoblast stem cell models to determine the sequence and mechanisms of these remodelling events. We show that cavitation of the embryonic tissue is followed by folding of extra-embryonic tissue to mediate the formation of a second extra-embryonic cavity...
November 2018: Nature Cell Biology
Mareike A Jordan, Dennis R Diener, Ludek Stepanek, Gaia Pigino
Movement of cargos along microtubules plays key roles in diverse cellular processes, from signalling to mitosis. In cilia, rapid movement of ciliary components along the microtubules to and from the assembly site is essential for the assembly and disassembly of the structure itself1 . This bidirectional transport, known as intraflagellar transport (IFT)2 , is driven by the anterograde motor kinesin-23 and the retrograde motor dynein-1b (dynein-2 in mammals)4,5 . However, to drive retrograde transport, dynein-1b must first be delivered to the ciliary tip by anterograde IFT6 ...
November 2018: Nature Cell Biology
Yevgeniy V Serebrenik, Ophir Shalem
No abstract text is available yet for this article.
November 2018: Nature Cell Biology
Qing Li, Yanjing Li, Suming Yang, Shuo Huang, Meng Yan, Yifu Ding, Wei Tang, Xiwen Lou, Qi Yin, Zhanfei Sun, Lei Lu, Huijuan Shi, Hongyan Wang, Yong Chen, Jinsong Li
CRISPR-mediated base editing can introduce single-nucleotide changes in the DNA of living cells. One intriguing application of base editing is to screen pivotal amino acids for protein function in vivo; however, it has not been achieved. Here, we report an enhanced third-generation base-editing system with extra nuclear localization sequences that can efficiently introduce a homozygous base mutation in embryonic stem cells. Meanwhile, we establish a strategy to generate base-mutant mice by injection of haploid embryonic stem cells carrying a constitutively expressed enhanced third-generation base-editing system (4B2N1) and single guide RNA into oocytes...
November 2018: Nature Cell Biology
Alexia-Ileana Zaromytidou
Given that the authors of 'FMN2 makes perinuclear actin to protect nuclei during confined migration and promote metastasis' (Skau et al. Cell 167, 1571-1585; 2016) have retracted their paper, I wish to retract this Research Highlight, which discussed the findings reported in that study.
November 2018: Nature Cell Biology
Rishi Raj Chhipa, Qiang Fan, Jane Anderson, Ranjithmenon Muraleedharan, Yan Huang, Georgianne Ciraolo, Xiaoting Chen, Ronald Waclaw, Lionel M Chow, Zaza Khuchua, Matthew Kofron, Matthew T Weirauch, Ady Kendler, Christopher McPherson, Nancy Ratner, Ichiro Nakano, Nupur Dasgupta, Kakajan Komurov, Biplab Dasgupta
In the version of this Article originally published, in ref. 34 the first author's name was spelled incorrectly. The correct reference is: Rodón, L. et al. Active CREB1 promotes a malignant TGFβ2 autocrine loop in glioblastoma. Cancer Discov. 10, 1230-1241 (2014). This has now been amended in all online versions of the Article.
November 2018: Nature Cell Biology
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