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Nature Cell Biology

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https://www.readbyqxmd.com/read/29784918/early-lineage-segregation-of-multipotent-embryonic-mammary-gland-progenitors
#1
Aline Wuidart, Alejandro Sifrim, Marco Fioramonti, Shigeru Matsumura, Audrey Brisebarre, Daniel Brown, Alessia Centonze, Anne Dannau, Christine Dubois, Alexandra Van Keymeulen, Thierry Voet, Cédric Blanpain
The mammary gland is composed of basal cells and luminal cells. It is generally believed that the mammary gland arises from embryonic multipotent progenitors, but it remains unclear when lineage restriction occurs and what mechanisms are responsible for the switch from multipotency to unipotency during its morphogenesis. Here, we perform multicolour lineage tracing and assess the fate of single progenitors, and demonstrate the existence of a developmental switch from multipotency to unipotency during embryonic mammary gland development...
May 21, 2018: Nature Cell Biology
https://www.readbyqxmd.com/read/29784917/clonal-analysis-of-notch1-expressing-cells-reveals-the-existence-of-unipotent-stem-cells-that-retain-long-term-plasticity-in-the-embryonic-mammary-gland
#2
Anna M Lilja, Veronica Rodilla, Mathilde Huyghe, Edouard Hannezo, Camille Landragin, Olivier Renaud, Olivier Leroy, Steffen Rulands, Benjamin D Simons, Silvia Fre
Recent lineage tracing studies have revealed that mammary gland homeostasis relies on unipotent stem cells. However, whether and when lineage restriction occurs during embryonic mammary development, and which signals orchestrate cell fate specification, remain unknown. Using a combination of in vivo clonal analysis with whole mount immunofluorescence and mathematical modelling of clonal dynamics, we found that embryonic multipotent mammary cells become lineage-restricted surprisingly early in development, with evidence for unipotency as early as E12...
May 21, 2018: Nature Cell Biology
https://www.readbyqxmd.com/read/29784916/mammary-lineage-restriction-in-development
#3
Philip Bland, Beatrice A Howard
No abstract text is available yet for this article.
May 21, 2018: Nature Cell Biology
https://www.readbyqxmd.com/read/29784915/gene-corrections-in-sight
#4
Christine Weber
No abstract text is available yet for this article.
May 21, 2018: Nature Cell Biology
https://www.readbyqxmd.com/read/29784914/a-biobank-for-bladder-cancer
#5
Christine Weber
No abstract text is available yet for this article.
May 21, 2018: Nature Cell Biology
https://www.readbyqxmd.com/read/29784913/modelling-pdac-niche-adaption
#6
Christine Weber
No abstract text is available yet for this article.
May 21, 2018: Nature Cell Biology
https://www.readbyqxmd.com/read/29784912/an-update-on-organoid-research
#7
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
May 21, 2018: Nature Cell Biology
https://www.readbyqxmd.com/read/29784911/organoids-test-drug-response
#8
Christine Weber
No abstract text is available yet for this article.
May 21, 2018: Nature Cell Biology
https://www.readbyqxmd.com/read/29784910/consent-for-governance-in-the-ethical-use-of-organoids
#9
Sarah N Boers, Annelien L Bredenoord
No abstract text is available yet for this article.
May 21, 2018: Nature Cell Biology
https://www.readbyqxmd.com/read/29713018/a-pax5-oct4-prdm1-developmental-switch-specifies-human-primordial-germ-cells
#10
Fang Fang, Benjamin Angulo, Ninuo Xia, Meena Sukhwani, Zhengyuan Wang, Charles C Carey, Aurélien Mazurie, Jun Cui, Royce Wilkinson, Blake Wiedenheft, Naoko Irie, M Azim Surani, Kyle E Orwig, Renee A Reijo Pera
Dysregulation of genetic pathways during human germ cell development leads to infertility. Here, we analysed bona fide human primordial germ cells (hPGCs) to probe the developmental genetics of human germ cell specification and differentiation. We examined the distribution of OCT4 occupancy in hPGCs relative to human embryonic stem cells (hESCs). We demonstrated that development, from pluripotent stem cells to germ cells, is driven by switching partners with OCT4 from SOX2 to PAX5 and PRDM1. Gain- and loss-of-function studies revealed that PAX5 encodes a critical regulator of hPGC development...
April 30, 2018: Nature Cell Biology
https://www.readbyqxmd.com/read/29674682/author-correction-segregation-of-mitochondrial-dna-heteroplasmy-through-a-developmental-genetic-bottleneck-in-human-embryos
#11
Vasileios I Floros, Angela Pyle, Sabine Dietmann, Wei Wei, Walfred W C Tang, Naoko Irie, Brendan Payne, Antonio Capalbo, Laila Noli, Jonathan Coxhead, Gavin Hudson, Moira Crosier, Henrik Strahl, Yacoub Khalaf, Mitinori Saitou, Dusko Ilic, M Azim Surani, Patrick F Chinnery
In the version of this Letter originally published, an author error led to the affiliations for Brendan Payne, Jonathan Coxhead and Gavin Hudson being incorrect. The correct affiliations are: Brendan Payne: 3 Wellcome Trust Centre for Mitochondrial Research, Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK. 6 Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK; this is a new affiliation 6 and subsequent existing affiliations have been renumbered. Jonathan Coxhead: 11 Genomic Core Facility, Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK; this is a new affiliation 11 and subsequent existing affiliations have been renumbered...
April 19, 2018: Nature Cell Biology
https://www.readbyqxmd.com/read/29674681/publisher-correction-msk1-regulates-luminal-cell-differentiation-and-metastatic-dormancy-in-er-breast-cancer
#12
Sylwia Gawrzak, Lorenzo Rinaldi, Sara Gregorio, Enrique J Arenas, Fernando Salvador, Jelena Urosevic, Cristina Figueras-Puig, Federico Rojo, Ivan Del Barco Barrantes, Juan Miguel Cejalvo, Marta Palafox, Marc Guiu, Antonio Berenguer-Llergo, Aikaterini Symeonidi, Anna Bellmunt, Daniela Kalafatovic, Anna Arnal-Estapé, Esther Fernández, Barbara Müllauer, Rianne Groeneveld, Konstantin Slobodnyuk, Camille Stephan-Otto Attolini, Cristina Saura, Joaquín Arribas, Javier Cortes, Ana Rovira, Montse Muñoz, Ana Lluch, Violeta Serra, Joan Albanell, Aleix Prat, Angel R Nebreda, Salvador Aznar Benitah, Roger R Gomis
In the version of this Article originally published, the boxes framing the two plots in Fig. 1g were misaligned from the axes due to a technical error. This has now been corrected in all versions of the Article.
April 19, 2018: Nature Cell Biology
https://www.readbyqxmd.com/read/29674680/author-correction-transient-scute-activation-via-a-self-stimulatory-loop-directs-enteroendocrine-cell-pair-specification-from-self-renewing-intestinal-stem-cells
#13
Jun Chen, Na Xu, Chenhui Wang, Pin Huang, Huanwei Huang, Zhen Jin, Zhongsheng Yu, Tao Cai, Renjie Jiao, Rongwen Xi
In the version of this Article originally published, the author had misnumbered the reference citations in the Methods, using numbers 1-14 instead of 46-59. These errors have now been corrected in all online versions of the Article.
April 19, 2018: Nature Cell Biology
https://www.readbyqxmd.com/read/29674679/publisher-correction-hitchhiking-on-selective-autophagy
#14
Christian Münch, Ivan Dikic
In the version of this News & Views originally published, owing to a technical error some incorrect characters were introduced into the second sentence of the main text, starting "Autophagy can be divided into non-selective...", where "caspringDE@2017n" should have read 'can'. This has now been corrected in all versions of this News & Views.
April 19, 2018: Nature Cell Biology
https://www.readbyqxmd.com/read/29662180/myc-sets-a-tumour-stroma-metabolic-loop
#15
Hilary A Coller
No abstract text is available yet for this article.
April 16, 2018: Nature Cell Biology
https://www.readbyqxmd.com/read/29662179/spatial-orchestration-of-mitochondrial-translation-and-oxphos-complex-assembly
#16
Stefan Stoldt, Dirk Wenzel, Kirsten Kehrein, Dietmar Riedel, Martin Ott, Stefan Jakobs
Oxidative phosphorylation (OXPHOS) is vital for the regeneration of the vast majority of ATP in eukaryotic cells 1 . OXPHOS is carried out by large multi-subunit protein complexes in the cristae membranes, which are invaginations of the mitochondrial inner membrane. The OXPHOS complexes are a mix of subunits encoded in the nuclear and mitochondrial genomes. Thus, the assembly of these dual-origin complexes is an enormous logistical challenge for the cell. Using super-resolution microscopy (nanoscopy) and quantitative cryo-immunogold electron microscopy, we determined where specific transcripts are translated and where distinct assembly steps of the dual-origin complexes in the yeast Saccharomyces cerevisiae occur...
April 16, 2018: Nature Cell Biology
https://www.readbyqxmd.com/read/29662178/defining-essential-genes-for-human-pluripotent-stem-cells-by-crispr-cas9-screening-in-haploid-cells
#17
Atilgan Yilmaz, Mordecai Peretz, Aviram Aharony, Ido Sagi, Nissim Benvenisty
The maintenance of pluripotency requires coordinated expression of a set of essential genes. Using our recently established haploid human pluripotent stem cells (hPSCs), we generated a genome-wide loss-of-function library targeting 18,166 protein-coding genes to define the essential genes in hPSCs. With this we could allude to an intrinsic bias of essentiality across cellular compartments, uncover two opposing roles for tumour suppressor genes and link autosomal-recessive disorders with growth-retardation phenotypes to early embryogenesis...
April 16, 2018: Nature Cell Biology
https://www.readbyqxmd.com/read/29662177/brd4-independence-in-ground-state-pluripotency
#18
Yaser Atlasi, Hendrik G Stunnenberg
No abstract text is available yet for this article.
April 16, 2018: Nature Cell Biology
https://www.readbyqxmd.com/read/29662176/cancer-cell-secreted-exosomal-mir-105-promotes-tumour-growth-through-the-myc-dependent-metabolic-reprogramming-of-stromal-cells
#19
Wei Yan, Xiwei Wu, Weiying Zhou, Miranda Y Fong, Minghui Cao, Juan Liu, Xiaojing Liu, Chih-Hong Chen, Oluwole Fadare, Donald P Pizzo, Jiawen Wu, Liang Liu, Xuxiang Liu, Andrew R Chin, Xiubao Ren, Yuan Chen, Jason W Locasale, Shizhen Emily Wang
Cancer and other cells residing in the same niche engage various modes of interactions to synchronize and buffer the negative effects of environmental changes. Extracellular microRNAs (miRNAs) have recently been implicated in the intercellular crosstalk. Here we show a mechanistic model involving breast-cancer-secreted, extracellular-vesicle-encapsulated miR-105, which is induced by the oncoprotein MYC in cancer cells and, in turn, activates MYC signalling in cancer-associated fibroblasts (CAFs) to induce a metabolic program...
April 16, 2018: Nature Cell Biology
https://www.readbyqxmd.com/read/29662175/pluripotency-transcription-factors-and-tet1-2-maintain-brd4-independent-stem-cell-identity
#20
Lydia W S Finley, Santosha A Vardhana, Bryce W Carey, Direna Alonso-Curbelo, Richard Koche, Yanyang Chen, Duancheng Wen, Bryan King, Megan R Radler, Shahin Rafii, Scott W Lowe, C David Allis, Craig B Thompson
A robust network of transcription factors and an open chromatin landscape are hallmarks of the naive pluripotent state. Recently, the acetyllysine reader Brd4 has been implicated in stem cell maintenance, but the relative contribution of Brd4 to pluripotency remains unclear. Here, we show that Brd4 is dispensable for self-renewal and pluripotency of embryonic stem cells (ESCs). When maintained in their ground state, ESCs retain transcription factor binding and chromatin accessibility independent of Brd4 function or expression...
April 16, 2018: Nature Cell Biology
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