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Current Hypertension Reports

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https://www.readbyqxmd.com/read/30229358/adipose-tissue-and-modulation-of-hypertension
#1
REVIEW
Eashita Das, Joon Ho Moon, Ju Hee Lee, Nikita Thakkar, Zdenka Pausova, Hoon-Ki Sung
PURPOSE OF REVIEW: Obesity is a major risk factor for the development of hypertension (HTN), a leading cause of cardiovascular morbidity and mortality. Growing body of research suggests that adipose tissue function is directly associated with the pathogenesis of obesity-related HTN. In this review, we will discuss recent research on the role of adipose tissue in blood pressure (BP) regulation and activation of brown adipose tissue (BAT) as a potentially new therapeutic means for obesity-related HTN...
September 18, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/30218213/sprint-and-the-kidney-what-have-we-learned
#2
REVIEW
Racquel Wells, Mahboob Rahman
PURPOSE OF REVIEW: To review the impact of the Systolic Blood Pressure Interventional Trial (SPRINT) on renal function and chronic kidney disease. RECENT FINDINGS: Hypertension is a risk factor for cardiovascular and kidney outcomes in patients with chronic kidney disease (CKD). The benefits of intensive blood pressure lowering in the CKD population in previous studies are unclear. The SPRINT compared standard (< 140 mmHg) and intensive (< 120 mmHg) blood pressure management in nondiabetic patients with high risk of cardiovascular disease...
September 14, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/30215153/skin-sodium-and-hypertension-a-paradigm-shift
#3
REVIEW
Viknesh Selvarajah, Kathleen Connolly, Carmel McEniery, Ian Wilkinson
PURPOSE OF REVIEW: Dietary sodium is an important trigger for hypertension and humans show a heterogeneous blood pressure response to salt intake. The precise mechanisms for this have not been fully explained although renal sodium handling has traditionally been considered to play a central role. RECENT FINDINGS: Animal studies have shown that dietary salt loading results in non-osmotic sodium accumulation via glycosaminoglycans and lymphangiogenesis in skin mediated by vascular endothelial growth factor-C, both processes attenuating the rise in BP...
September 13, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/30203149/catheter-based-renal-denervation-for-hypertension
#4
REVIEW
Raymond R Townsend, Paul A Sobotka
PURPOSE OF REVIEW: This review was undertaken to update readers on the field of therapeutic renal denervation for hypertension during the 2016 through 2018 period. RECENT FINDINGS: After the failure of Symplicity HTN-3 to meet its top line objective, intense scrutiny revealed several possible concerns addressed by the newer investigations into the area of renal denervation. These included better device technology, more intense subject monitoring for off-protocol antihypertensive drug usage, and deeper penetration into the renal vasculature by the interventionist...
September 10, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/30194545/modulation-of-sympathetic-overactivity-to-treat-resistant-hypertension
#5
REVIEW
Raven Voora, Alan L Hinderliter
PURPOSE OF REVIEW: To review the role and evidence for sympathetic overactivity in resistant hypertension and review the therapies that have been studied to modulate the sympathetic nervous system to treat resistant hypertension, with a focus on non-pharmacologic therapies such as renal denervation, baroreflex activation therapy, and carotid body ablation. RECENT FINDINGS: Based on the two best current techniques available for assessing sympathetic nerve activity, resistant hypertension is characterized by increased sympathetic nerve activity...
September 7, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/30159611/candidate-gene-genome-wide-association-and-bioinformatic-studies-in-pre-eclampsia-a-review
#6
REVIEW
Semone Thakoordeen, Jagidesa Moodley, Thajasvarie Naicker
PURPOSE OF REVIEW: Regardless of the familial linkage reported in pre-eclampsia development, understanding the polymorphic genes associated with pre-eclampsia remains limited. Hence, this review aims to outline the main genetic factors that have been investigated in respect to pre-eclampsia development. RECENT FINDINGS: It is apparent that different genes show significance in varying populations. Notably, it is reported that apolipoprotein-1 gene polymorphisms are associated with pre-eclampsia development in an African-American population, which may be worthwhile to investigate in a Black South African cohort...
August 29, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/30145617/novel-medical-treatments-for-hypertension-and-related-comorbidities
#7
REVIEW
Jared Davis, Suzanne Oparil
PURPOSE OF REVIEW: The purpose of this review is to summarize the most recent data available on advances in development of novel medical treatments for hypertension and related comorbidities. RECENT FINDINGS: Approximately half of all hypertensive patients have not achieved goal blood pressure with current available antihypertensive medications. Recent landmark studies and new hypertension guidelines have called for stricter blood pressure control, creating a need for better strategies for lowering blood pressure...
August 25, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/30120623/enhancing-mitochondrial-health-to-treat-hypertension
#8
REVIEW
Alfonso Eirin, Amir Lerman, Lilach O Lerman
PURPOSE OF REVIEW: This review summarizes literature pertaining to the dawning field of therapeutic targeting of mitochondria in hypertension and discusses the potential of these interventions to ameliorate hypertension-induced organ damage. RECENT FINDINGS: In recent years, mitochondrial dysfunction has been reported as an important contributor to the pathogenesis of hypertension-related renal, cardiac, and vascular disease. This in turn prompted development of novel mitochondria-targeted compounds, some of which have shown promising efficacy in experimental studies and safety in clinical trials...
August 17, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/30109433/mineralocorticoids-and-cardiovascular-disease-in-females-with-insulin-resistance-and-obesity
#9
REVIEW
Manav Nayyar, Guido Lastra, Camila Manrique Acevedo
PURPOSE OF THE REVIEW: In the present review, we will discuss the evidence and the mechanisms underlying the complex interplay between obesity, mineralocorticoid receptor activation, and cardiovascular dysfunction with special emphasis on the pathogenesis of cardiovascular disease (CVD) in obese and insulin-resistant females. RECENT FINDINGS: Since the initial isolation of aldosterone in 1953 and the cloning of the mineralocorticoid receptor (MR) decades later, our understanding has expanded tremendously regarding their involvement in the pathogenesis of CVD...
August 14, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/30090982/environmental-toxicant-exposure-and-hypertensive-disorders-of-pregnancy-recent-findings
#10
REVIEW
Linda G Kahn, Leonardo Trasande
PURPOSE OF REVIEW: To assess the strength of evidence for associations between environmental toxicants and hypertensive disorders of pregnancy, suggest potential biological mechanisms based on animal and in vitro studies, and highlight avenues for future research. RECENT FINDINGS: Evidence is strongest for links between persistent chemicals, including lead, cadmium, organochlorine pesticides, and polycyclic biphenyls, and preeclampsia, although associations are sometimes not detectable at low-exposure levels...
August 8, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/30088110/effectiveness-of-mhealth-interventions-in-improving-medication-adherence-among-people-with-hypertension-a-systematic-review
#11
REVIEW
Shangzhi Xiong, Hudson Berkhouse, Mary Schooler, William Pu, Anli Sun, Enying Gong, Lijing L Yan
PURPOSE OF REVIEW: This study aims to systematically review existing evidence on the effectiveness of mobile health technology (mHealth) interventions in addressing medication adherence among people with hypertension. RECENT FINDINGS: Twenty-one studies of mHealth interventions were included in the final review after systematic searching and screening of publications from 2000 to 2017 in PubMed, Web of Science, and Embase. Key features of the mHealth interventions include high intervention intensity, multifactorial components, and patient-centered approaches with tailored content and interaction...
August 7, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/30062568/the-role-of-out-of-clinic-blood-pressure-measurements-in-preventing-hypertension
#12
REVIEW
Yi Chen, Dong-Yan Zhang, Yan Li, Ji-Guang Wang
PURPOSE OF REVIEW: One of the possible strategies for preventing hypertension is identifying high-risk people and then implementing lifestyle modifications or therapeutic interventions. Out-of-clinic blood pressure measurements, either home or ambulatory blood pressure monitoring, may identify people with early blood pressure elevation or white-coat or masked hypertension and potentially help prevent hypertension. In this review, we will summarize the evidence on the role of out-of-clinic blood pressure measurements in preventing hypertension either from prehypertension or high normal or elevated blood pressure, or from white-coat or masked hypertension...
July 30, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/30051236/the-incidence-and-pathophysiology-of-the-obesity-paradox-should-peritoneal-dialysis-and-kidney-transplant-be-offered-to-patients-with-obesity-and-end-stage-renal-disease
#13
REVIEW
Ramzi Vareldzis, Mihran Naljayan, Efrain Reisin
PURPOSE OF REVIEW: To educate nephrologists and primary-care physicians about the incidence, pathophysiology, and survival benefits of the obesity paradox in end-stage renal disease (ESRD). This review also discusses the future of kidney transplant and peritoneal dialysis in obese dialysis patients. RECENT FINDINGS: Obesity paradox in ESRD was first reported three decades ago, and since then, there have been several epidemiological studies that confirmed the phenomenon...
July 26, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/30051151/phosphodiesterase-inhibition-in-the-treatment-of-preeclampsia-what-is-new
#14
REVIEW
Anne Brandolt Larré, Fernando Sontag, Débora Montenegro Pasin, Nathália Paludo, Rayssa Ruszkowski do Amaral, Bartira Ercília Pinheiro da Costa, Carlos Eduardo Poli-de-Figueiredo
PURPOSE OF REVIEW: The present study intends to review the possibility of using phosphodiesterase inhibitors as a treatment option for preeclampsia, addressing potential risks and benefits. RECENT FINDINGS: Preeclampsia is the most common hypertensive disorder of pregnancy, often responsible for severe maternal and fetal complications, which can lead to early pregnancy termination and death. Despite the numerous studies, its pathophysiology is still unclear, although it seems to involve a multiplicity of complex factors related to angiogenesis, ineffective vasodilation, oxidative stress, inflammatory cytokines, and endothelial dysfunction...
July 26, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/30051144/big-data-and-blood-pressure-control-insights-from-the-pamela-and-bp-care-study-cohorts
#15
REVIEW
M Bombelli, Rita Facchetti, Giuseppe Mancia, Guido Grassi
PURPOSE OF REVIEW: The paper examines the patterns of BP control achieved in two large scale observational studies, i.e., the Pressioni Arteriose Monitorate E Loro Associazioni (PAMELA) study and the Blood Pressure control rate and CArdiovascular Risk profilE (BP-CARE), carried out in the general population and in treated hypertensive patients, respectively. RECENT FINDINGS: It is well known that only a minor fraction among the treated hypertensive patients exhibits a good blood pressure control...
July 26, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/30006901/the-effects-of-oral-taurine-on-resting-blood-pressure-in-humans-a-meta-analysis
#16
REVIEW
Mark Waldron, Stephen David Patterson, Jamie Tallent, Owen Jeffries
PURPOSE OF REVIEW: The aims of this meta-analysis were to investigate the effects of orally administered isolated taurine on resting systolic blood pressure (SBP) and diastolic blood pressure (DBP) in humans. RECENT FINDINGS: There is growing evidence that taurine deficiency is associated with hypertension and that oral supplementation can have antihypertensive effects in humans. However, these investigations have been conducted across a number of decades and populations and have not been collectively reviewed...
July 13, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/29992526/an-overview-of-metabolic-phenotyping-in-blood-pressure-research
#17
REVIEW
Ioanna Tzoulaki, Aikaterini Iliou, Emmanuel Mikros, Paul Elliott
PURPOSE OF THE REVIEW: This review presents the analytical techniques, processing and analytical steps used in metabolomics phenotyping studies, as well as the main results from epidemiological studies on the associations between metabolites and high blood pressure. RECENT FINDINGS: A variety of metabolomic approaches have been applied to a range of epidemiological studies to uncover the pathophysiology of high blood pressure. Several pathways have been suggested in relation to blood pressure including the possible role of the gut microflora, inflammatory, oxidative stress, and lipid pathways...
July 10, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/29992504/orexins-sleep-and-blood-pressure
#18
REVIEW
Mariusz Sieminski, Jacek Szypenbejl, Eemil Partinen
PURPOSE OF REVIEW: The aim of this review was to summarize collected data on the role of orexin and orexin neurons in the control of sleep and blood pressure. RECENT FINDINGS: Although orexins (hypocretins) have been known for only 20 years, an impressive amount of data is now available regarding their physiological role. Hypothalamic orexin neurons are responsible for the control of food intake and energy expenditure, motivation, circadian rhythm of sleep and wake, memory, cognitive functions, and the cardiovascular system...
July 10, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/29992362/visceral-adipose-tissue-accumulation-and-residual-cardiovascular-risk
#19
REVIEW
Thierry H Le Jemtel, Rohan Samson, Gregory Milligan, Abhishek Jaiswal, Suzanne Oparil
PURPOSE OF THE REVIEW: Low-grade systemic inflammation increases residual cardiovascular risk. The pathogenesis of low-grade systemic inflammation is not well understood. RECENT FINDINGS: Visceral adipose tissue accumulates when the subcutaneous adipose tissue can no longer store excess nutrients. Visceral adipose tissue inflammation initially facilitates storage of nutrients but with time become maladaptive and responsible for low-grade systemic inflammation. Control of low-grade systemic inflammation requires reversal of visceral adipose tissue accumulation with intense and sustained aerobic exercise or bariatric surgery...
July 10, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/29992361/the-role-of-uric-acid-in-preeclampsia-is-uric-acid-a-causative-factor-or-a-sign-of-preeclampsia
#20
REVIEW
Olive P Khaliq, Tadashi Konoshita, Jagidesa Moodley, Thajasvarie Naicker
PURPOSE OF REVIEW: Because of the significant discrepancies on this topic, this review will focus on the role of uric acid in PE, uric acid as a predictor of preeclampsia and fetal growth retardation. We considered eligible review and original articles relevant to the research question. RECENT FINDINGS: Hypertensive disorders of pregnancy such as preeclampsia (PE) are a major cause of both maternal and fetal morbidity and mortality worldwide. Uric acid has been reported as a key factor contributing to the pathogenesis of PE...
July 10, 2018: Current Hypertension Reports
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