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Current Hypertension Reports

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https://www.readbyqxmd.com/read/27889904/how-to-screen-for-non-adherence-to-antihypertensive-therapy
#1
REVIEW
Pankaj Gupta, Prashanth Patel, Robert Horne, Heather Buchanan, Bryan Williams, Maciej Tomaszewski
The quality of assessment of non-adherence to treatment in hypertensive is poor. Within this review, we discuss the different methods used to assess adherence to blood-pressure-lowering medications in hypertension patients. Subjective reports such as physicians' perceptions are inaccurate, and questionnaires completed by patients tend to overreport adherence and show a low diagnostic specificity. Indirect objective methods such as pharmacy database records can be useful, but they are limited by the robustness of the recorded data...
December 2016: Current Hypertension Reports
https://www.readbyqxmd.com/read/27878563/asymptomatic-elevated-bp-and-the-hypertensive-insurgency
#2
REVIEW
Candace D McNaughton, Phillip Levy
No abstract text is available yet for this article.
December 2016: Current Hypertension Reports
https://www.readbyqxmd.com/read/27837398/role-of-microrna-in-endothelial-dysfunction-and-hypertension
#3
REVIEW
Miruna Nemecz, Nicoleta Alexandru, Gabriela Tanko, Adriana Georgescu
PURPOSE OF REVIEW: Hypertension is either a cause or a consequence of the endothelial dysfunction and a major risk factor for cardiovascular disease (CVD). In vitro and in vivo studies established that microRNAs (miRNAs) are decisive for endothelial cell gene expression and function in various pathological conditions associated with CVD. This review provides an overview of the miRNA role in controlling the key connections between endothelial dysfunction and hypertension. RECENT FINDINGS: Herein we summarize the present understanding of mechanisms underlying hypertension and its associated endothelial dysfunction as well as the miRNA role in endothelial cells with accent on the modulation of renin-angiotensin-aldosterone-system, nitric oxide, oxidative stress and on the control of vascular inflammation and angiogenesis in relation to endothelial dysfunction in hypertension...
December 2016: Current Hypertension Reports
https://www.readbyqxmd.com/read/27837397/from-arb-to-arni-in-cardiovascular-control
#4
REVIEW
Estrellita Uijl, Lodi C W Roksnoer, Ewout J Hoorn, A H Jan Danser
Coexistence of hypertension, diabetes mellitus and chronic kidney disease synergistically aggravates the risk of cardiovascular and renal morbidity and mortality. These high-risk, multi-morbid patient populations benefit less from currently available anti-hypertensive treatment. Simultaneous angiotensin II type 1 receptor blockade and neprilysin inhibition ('ARNI') with valsartan/sacubitril (LCZ696) might potentiate the beneficial effects of renin-angiotensin-aldosterone inhibition by reinforcing its endogenous counterbalance, the natriuretic peptide system...
December 2016: Current Hypertension Reports
https://www.readbyqxmd.com/read/27837396/prognostic-importance-of-ambulatory-blood-pressure-monitoring-in-resistant-hypertension-is-it-all-that-matters
#5
REVIEW
Claudia R L Cardoso, Gil F Salles
PURPOSE OF REVIEW: This article reviews the current knowledge on the prognostic importance of ambulatory blood pressure (BP) monitoring parameters in patients with apparent treatment-resistant hypertension. RECENT FINDINGS: Although mean 24-h ambulatory BPs have been consistently established as better cardiovascular risk predictors than clinic (office) BPs in several clinical settings, and ambulatory BP monitoring is generally indicated in patients with resistant hypertension; there were only five previous longitudinal prospective studies that specifically evaluated the prognostic importance of ambulatory BP monitoring parameters in resistant hypertensive patients...
December 2016: Current Hypertension Reports
https://www.readbyqxmd.com/read/27832457/pulmonary-arterial-hypertension-and-the-sex-hormone-paradox
#6
REVIEW
Andrew Foderaro, Corey E Ventetuolo
PURPOSE OF REVIEW: Prevalence and outcome differences between women and men with pulmonary arterial hypertension (PAH) raise questions about the role of sex hormones in disease pathobiology. This review will summarize the current understanding of sex and sex hormone pathways and their influence on heart-lung function in health and in disease. RECENT FINDINGS: Female sex has been shown to be a risk factor for the development of PAH, but women have improved survival compared to men with PAH...
November 2016: Current Hypertension Reports
https://www.readbyqxmd.com/read/27787838/a-clinical-perspective-contribution-of-dysfunctional-perivascular-adipose-tissue-pvat-to-cardiovascular-risk
#7
REVIEW
Xiaoming Lian, Maik Gollasch
Perivascular adipose tissue (PVAT) is now recognized as an important paracrine organ influencing the homeostasis of the vessel wall, regional blood flow and peripheral arterial resistance. There is remarkable phenotypic variability and plasticity of PVAT among various vascular beds, exhibiting phenotypes from white to brown and beige adipocytes. PVAT dysfunction is characterized by disturbed secretion of various adipokines, which, together with endothelial dysfunction, contribute to hypertension and cardiovascular disease (CVD)...
November 2016: Current Hypertension Reports
https://www.readbyqxmd.com/read/27787837/effects-of-aspirin-on-endothelial-function-and-hypertension
#8
REVIEW
Mikhail S Dzeshka, Alena Shantsila, Gregory Y H Lip
PURPOSE OF REVIEW: Endothelial dysfunction is intimately related to the development of various cardiovascular diseases, including hypertension, and is often used as a target for pharmacological treatment. The scope of this review is to assess effects of aspirin on endothelial function and their clinical implication in arterial hypertension. RECENT FINDINGS: Emerging data indicate the role of platelets in the development of vascular inflammation due to the release of proinflammatory mediators, for example, triggered largely by thromboxane...
November 2016: Current Hypertension Reports
https://www.readbyqxmd.com/read/27787836/should-all-patients-with-resistant-hypertension-receive-spironolactone
#9
REVIEW
Ján Rosa, Tomáš Zelinka, Ondřej Petrák, Branislav Štrauch, Robert Holaj, Jiří Widimský
PURPOSE OF REVIEW: Resistant hypertension is a common clinical situation. Identification of true resistant hypertension (using 24-h ambulatory blood pressure monitoring to exclude white coat phenomenon, excluding secondary causes and non-adherence to treatment) is important mostly because of the application of a proper therapeutic approach and the higher cardiovascular risk of these patients. This review surveys recent studies, with a focus on mineralocorticoid receptor antagonists, including spironolactone, in the treatment of resistant hypertension...
November 2016: Current Hypertension Reports
https://www.readbyqxmd.com/read/27787835/white-coat-hypertension-to-treat-or-not-to-treat
#10
REVIEW
Cesare Cuspidi, Carla Sala, Guido Grassi, Giuseppe Mancia
Definition of white coat hypertension (WCH) traditionally relies on elevated office blood pressure (BP) during repeated visits concomitant with normal out-of-office BP values, as assessed by home and/or 24-h ambulatory BP monitoring measurements. Accumulating evidence focusing on the association of WCH with target organ damage and, more importantly, with cardiovascular events indicates that the risk conveyed by this condition is intermediate between normotension and sustained hypertension. This article will review a number of issues concerning WCH with particular emphasis on the following: (1) prevalence and clinical correlates, (2) association with target organ damage and cardiovascular events, (3) therapeutic interventions...
November 2016: Current Hypertension Reports
https://www.readbyqxmd.com/read/27785714/endoluminal-treatments-for-obesity-and-related-hypertension-updates-review-and-clinical-perspective
#11
REVIEW
Courtney Cripps, Mitchell Roslin
PURPOSE OF REVIEW: Obesity is a global epidemic that continues to grow and results in related conditions such as hypertension and diabetes despite established interventions, thus suggesting the importance of new technologies. RECENT FINDINGS: Endoscopic interventions are vast in scope and effectiveness. Intra-gastric balloons appear to dominate the field at this time, but a recent FDA-approved technique, the Aspire device, may soon cause a shift in the treatment paradigm...
November 2016: Current Hypertension Reports
https://www.readbyqxmd.com/read/27739020/isolated-systolic-hypertension-in-young-and-middle-aged-adults
#12
Yuichiro Yano, Donald M Lloyd-Jones
Young and middle-aged adults (ages ≤50 years) are increasingly prone to stroke, kidney disease, and worsening cardiovascular disease (CVD) mortality. An alarming increase in the prevalence of high blood pressure (BP) may underlie the adverse trend. However, there is often uncertainty in BP management for young and middle-aged adults. Isolated systolic hypertension (ISH) is one such example. Whether ISH in young and middle-aged adults represents "pseudo" or "spurious" hypertension is still being debated. ISH in young and middle-aged adults is a heterogeneous entity; some individuals appear to have increased stroke volume, whereas others have stiffened aortae, or both...
November 2016: Current Hypertension Reports
https://www.readbyqxmd.com/read/27739019/hypertension-in-athletes-and-active-populations
#13
Kevin T Schleich, M Kyle Smoot, Michael E Ernst
Hypertension continues to be the most common cardiovascular disorder in the USA and worldwide. While generally considered a disorder of aging individuals, hypertension is more prevalent in athletes and the active population than is generally appreciated. The timely detection, diagnosis, and appropriate treatment of hypertension in athletes must focus on both adequately managing the disorder and ensuring safe participation in sport while not compromising exercise capacity. This publication focuses on appropriately diagnosing hypertension, treating hypertension in the athletic population, and suggesting follow-up and participation guidelines for athletes...
November 2016: Current Hypertension Reports
https://www.readbyqxmd.com/read/27730495/management-of-dyslipidemia-in-patients-with-hypertension-diabetes-and-metabolic-syndrome
#14
Sundararajan Srikanth, Prakash Deedwania
PURPOSE OF REVIEW: The purpose of this review is to discuss dyslipidemia in the various common clinical conditions including hypertension, diabetes mellitus, and metabolic syndrome and review the current therapeutic strategy in these settings. RECENT FINDINGS: Dyslipidemias are common in patients with hypertension, diabetes mellitus, and metabolic syndrome. Epidemiologic studies have shown a strong correlation between serum lipid levels and risk of atherosclerotic cardiovascular disease...
October 2016: Current Hypertension Reports
https://www.readbyqxmd.com/read/27699587/effects-of-antihypertensive-therapy-on-blood-pressure-variability
#15
Kazuo Eguchi
PURPOSE OF REVIEW: The study aims to summarize the effect of antihypertensive therapy on various types of BP variability in hypertensives. RECENT FINDINGS: Visit-to-visit, day-by-day, and ambulatory BPV are markers of target organ damage and cardiovascular prognosis, as was shown in the LIFE study, which showed that visit-to-visit variability in BP predicted cardiovascular events in treated hypertensive patients with left ventricular hypertrophy. Long-acting calcium channel blockers (CCBs) may be a preferable treatment in reducing BPV measures...
October 2016: Current Hypertension Reports
https://www.readbyqxmd.com/read/27696189/hyperuricemia-hypertension-and-chronic-kidney-disease-an-emerging-association
#16
Samir G Mallat, Sahar Al Kattar, Bassem Y Tanios, Abdo Jurjus
Uric acid is a product of purine metabolism and has been linked to gout and kidney calculi. Chronic kidney disease (CKD) and hypertension (HTN) are two major public health problems, and both are associated with increased risk of cardiovascular events. Emerging evidence suggests a pathogenic role of hyperuricemia in the development of HTN and CKD, in addition to progression of CKD, by inducing renal inflammation, endothelial dysfunction, and activation of the renin-angiotensin system. In addition, several epidemiological studies have linked hyperuricemia with an increased risk of HTN and CKD...
October 2016: Current Hypertension Reports
https://www.readbyqxmd.com/read/27671491/common-substances-that-may-contribute-to-resistant-hypertension-and-recommendations-for-limiting-their-clinical-effects
#17
Samuel J Jurca, William J Elliott
PURPOSE OF REVIEW: The purpose of this review is to highlight common or important substances or habits that elevate blood pressure and offer suggestions, based on recent literature, to limit their use or effects. RECENT FINDINGS: Despite decades of advice to the general populace from public health authorities to avoid or reduce dietary sodium and non-steroidal anti-inflammatory drug (NSAID) use, more evidence has accumulated from nationwide surveys, clinical trials, and pathophysiological or mechanistic studies that show how important these modalities can (and should) be for hypertensive and prehypertensive individuals and the general population...
October 2016: Current Hypertension Reports
https://www.readbyqxmd.com/read/27659178/twenty-four-hour-ambulatory-pulse-wave-analysis-in-hypertension-management-current-evidence-and-perspectives
#18
REVIEW
Stefano Omboni, Igor N Posokhov, Yulia V Kotovskaya, Athanase D Protogerou, Jacques Blacher
The predictive value of vascular biomarkers such as pulse wave velocity (PWV), central arterial pressure (CAP), and augmentation index (AIx), obtained through pulse wave analysis (PWA) in resting conditions, has been documented in a variety of patient groups and populations. This allowed to make appropriate recommendations in clinical practice guidelines of several scientific societies. Due to advances in technologies, largely operator-independent methods are currently available for estimating vascular biomarkers also in ambulatory conditions, over the 24 h...
October 2016: Current Hypertension Reports
https://www.readbyqxmd.com/read/27628629/the-renal-sodium-bicarbonate-cotransporter-nbce2-is-it-a-major-contributor-to-sodium-and-ph-homeostasis
#19
REVIEW
Robin A Felder, Pedro A Jose, Peng Xu, John J Gildea
The sodium bicarbonate cotransporter (NBCe2, aka NBC4) was originally isolated from the human testis and heart (Pushkin et al. IUBMB Life 50:13-19, 2000). Subsequently, NBCe2 was found in diverse locations where it plays a role in regulating sodium and bicarbonate transport, influencing intracellular, extracellular, interstitial, and ultimately plasma pH (Boron et al. J Exp Biol. 212:1697-1706, 2009; Parker and Boron, Physiol Rev. 93:803-959, 2013; Romero et al. Mol Asp Med. 34:159-182, 2013). NBCe2 is located in human and rodent renal-collecting duct and proximal tubule...
September 2016: Current Hypertension Reports
https://www.readbyqxmd.com/read/27614755/salt-sensitivity-challenging-and-controversial-phenotype-of-primary-hypertension
#20
REVIEW
Rossella Iatrino, Paolo Manunta, Laura Zagato
Increases in life expectancy and cardiovascular adverse events in patients with hypertension highlight the need for new risk-reduction strategies to reduce the burden of degenerative diseases. Among the environmental factors, high salt consumption is currently considered the most important risk factor of hypertension. However, while high salt intake significantly raises blood pressure in some individuals, others do not show variation or even decrease their blood pressure. This heterogeneity is respectively classified as salt sensitivity and salt resistance...
September 2016: Current Hypertension Reports
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