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Current Hypertension Reports

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https://www.readbyqxmd.com/read/28929454/antihypertensive-therapies-and-left-ventricular-hypertrophy
#1
REVIEW
Elsayed Z Soliman, Ronald J Prineas
PURPOSE OF REVIEW: It is widely accepted that successful lowering of blood pressure (BP) in patients with hypertension leads to regression of left ventricular hypertrophy (LVH). However, whether differences exist among pharmacological BP-lowering therapies is debated. In this report, we discuss these differences in light of recent literature and the position of extant practice guidelines. RECENT FINDINGS: Studies comparing the effects of antihypertensive classes on LVH regression reached different conclusions, but the overall direction which is reflected in current society guidelines is that successful lowering of BP is more important than selection of an individual antihypertensive class...
September 19, 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/28929450/intrarenal-angiotensin-converting-enzyme-the-old-and-the-new
#2
REVIEW
Silas Culver, Caixia Li, Helmy M Siragy
PURPOSE OF REVIEW: The intrarenal renin-angiotensin-aldosterone system (RAS) is an independent paracrine hormonal system with an increasingly prominent role in hypertension and renal disease. Two enzyme components of this system are angiotensin-converting enzyme (ACE) and more recently discovered ACE2. The purpose of this review is to describe recent discoveries regarding the roles of intrarenal ACE and ACE2 and their interaction. RECENT FINDINGS: Renal tubular ACE contributes to salt-sensitive hypertension...
September 19, 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/28929438/masked-hypertension
#3
REVIEW
Yuichiro Yano, Suzanne Oparil
No abstract text is available yet for this article.
September 19, 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/28929331/glutamatergic-regulation-of-hypothalamic-presympathetic-neurons-in-hypertension
#4
De-Pei Li, Hui-Lin Pan
Elevated sympathetic vasomotor tone emanating from the brain is a major mechanism involved in the development of hypertension. Increased glutamatergic excitatory input to presympathetic neurons in the paraventricular nucleus (PVN) of the hypothalamus leads to increased sympathetic outflow in various animal models of hypertension. Recent studies have revealed molecular and cellular mechanisms underlying enhanced glutamatergic synaptic input to PVN presympathetic neurons in hypertension. In this review article, we summarize recent findings on changes in inotropic and metabotropic glutamate receptors, at both presynaptic and postsynaptic sites, responsible for increased glutamatergic input to PVN presympathetic neurons in hypertension...
September 19, 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/28921053/herbs-used-for-the-treatment-of-hypertension-and-their-mechanism-of-action
#5
REVIEW
Steven G Chrysant, George S Chrysant
There is great interest lately, in the use of herbs for the treatment of hypertension and cardiovascular disease (CVD). Herbs and plants contain many phytochemicals that have been effective in the treatment of CVD and hypertension. Accumulating scientific evidence provides a reason for the use of herbs by health practitioners for treating their patients. The rationale for this expanding use of herbs is the belief of patients in a "holistic medicine" and that herbs are natural, safe, and effective. However, there are reasons of concern with the use of herbs, because they are not regulated or supervised carefully and their use could lead to serious complications or interactions with their combination with traditional medicines...
September 18, 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/28825211/response-to-the-letter-from-gay-and-kolkhof
#6
REVIEW
Elvira O Gosmanova
No abstract text is available yet for this article.
September 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/28785887/quality-of-meta-analyses-for-randomized-trials-in-the-field-of-hypertension-an-updated-and-improved-systematic-review
#7
REVIEW
George C Roush, Fiorella Perez, Ramy Abdelfattah, Andrew Prindle, Elie Jean, Tanveer Singh, John B Kostis, William J Kostis, William J Elliott, Jesse A Berlin
Publications of hypertension-related meta-analyses (MAs) have increased exponentially in the past 25 years and now average 8/month. Theoretically, this is facilitating evidence-based management of patients. However, some practitioners and authors of guidelines have questioned the quality of published MAs. By extending a prior review, we have assessed the quality of 212 hypertension-related meta-analyses over 5 years based on systematically searching three computerized libraries. Seventeen criteria grouped into four domains of quality yielded the following results: (1) Assessment of trial quality was accomplished in 89% of MAs, and 38% analyzed trials in subgroups of trial quality where appropriate...
September 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/28780627/primary-pediatric-hypertension-current-understanding-and-emerging-concepts
#8
REVIEW
Andrew C Tiu, Michael D Bishop, Laureano D Asico, Pedro A Jose, Van Anthony M Villar
The rising prevalence of primary pediatric hypertension and its tracking into adult hypertension point to the importance of determining its pathogenesis to gain insights into its current and emerging management. Considering that the intricate control of BP is governed by a myriad of anatomical, molecular biological, biochemical, and physiological systems, multiple genes are likely to influence an individual's BP and susceptibility to develop hypertension. The long-term regulation of BP rests on renal and non-renal mechanisms...
September 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/28770533/hyperuricemia-type-2-diabetes-mellitus-and-hypertension-an-emerging-association
#9
REVIEW
Ibrahim Mortada
Uric acid is the final oxidation product of purine metabolism in circulation and has been associated with the occurrence of gout and kidney stones. Type 2 diabetes mellitus and hypertension are two important public health challenges, and both are linked to increased risk of cardiovascular events. Hyperuricemia has recently emerged as an independent risk factor in the development of type 2 diabetes mellitus and hypertension through several proposed mechanisms. Few clinical trials investigated the use of uric acid lowering agents in the management of these two disease entities; however, their results provided encouraging evidence to a potential role for these agents in fighting disease burden...
September 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/28755274/regression-of-left-ventricular-mass-after-bariatric-surgery
#10
REVIEW
Thierry H Le Jemtel, Rohan Samson, Abhishek Jaiswal, Eliza B Lewine, Suzanne Oparil
Notwithstanding the presence of hypertension, obstructive sleep apnea, or both, obesity is associated with increased left ventricular (LV) mass. The effects of bariatric surgery on LV mass have been sparsely investigated by M-mode and two-dimensional (2D) echocardiography. Overall, Roux-en-Y gastric bypass, adjustable gastric banding, and sleeve gastrectomy reduce LV mass. However, the reduction in LV mass is extremely variable. Besides duration and severity of obesity, presence of hypertension, obstructive sleep apnea or both, and type of surgical procedures, the inaccuracy of M-mode and 2D echocardiography for assessment of LV mass contributes to the variable effects of bariatric surgery on LV mass...
September 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/28836157/relevance-of-haemodynamics-in-treating-pre-eclampsia
#11
REVIEW
Christoph Lees, Enrico Ferrazzi
Blood pressure is a way of describing the end result of changes in cardiac output, intravascular volume and peripheral resistance. It has certain advantages in that it is a reproducible and easily measured parameter, but in itself, it offers only a limited understanding of the underlying haemodynamics. In pregnancy, profound haemodynamic changes occur and in hypertensive diseases of pregnancy defining a condition by blood pressure alone risks missing the underlying cause. Partly, this has been a problem of ascribing the cause of hypertensive syndromes to the placenta which has inhibited rigorous research into other possible causes of haemodynamic dysfunction...
August 23, 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/28822115/comments-on-lyubarova-r-and-gosmanova-e-o-mineralocorticoid-receptor-blockade-in-end-stage-renal-disease-current-hypertension-reports-2017-19-5
#12
REVIEW
Alain Gay, Peter Kolkhof
No abstract text is available yet for this article.
August 18, 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/28801878/pulse-waveform-analysis-is-it-ready-for-prime-time
#13
REVIEW
Bernhard Hametner, Siegfried Wassertheurer
PURPOSE OF REVIEW: Arterial pulse waveform analysis has a long tradition but has not pervaded medical routine yet. This review aims to answer the question whether the methodology is ready for prime time use. The current methodological consensus is assessed, existing technologies for waveform measurement and pulse wave analysis are discussed, and further needs for a widespread use are proposed. RECENT FINDINGS: A consensus document on the understanding and analysis of the pulse waveform was published recently...
August 11, 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/28791529/effects-of-raas-inhibitors-in-patients-with-kidney-disease
#14
REVIEW
Fan Zhang, Hong Liu, Di Liu, Yexin Liu, Huiqiong Li, Xia Tan, Fuyou Liu, Youming Peng, Hongqing Zhang
Proteinuria and decline of renal function are associated with progression of kidney disease. The Renin Angiotensin Aldosterone System (RAAS) plays an important role in blood pressure regulation, fluid volume, and sodium balance. Overactivity of RAAS contributes to the pathogenesis of a variety of clinical conditions including progress of chronic kidney disease (CKD). This review summarizes the use of RAAS inhibitors as dual therapy or monotherapy in different stages of kidney disease. Experimental and clinical studies have demonstrated RAAS inhibitors prevent proteinuria, kidney fibrosis and slow decline of renal function and thus play a protective role in both early and end stages of kidney disease...
August 8, 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/28755159/managing-hypertension-in-the-elderly-what-is-different-what-is-the-same
#15
REVIEW
Wilbert S Aronow
PURPOSE OF REVIEW: The goal is to discuss management of hypertension in the elderly. RECENT FINDINGS: At 3.14-year follow-up of 2636 persons ≥75 years in the Systolic Blood Pressure Intervention Trial (SPRINT), compared with a systolic blood pressure (SBP) goal of <140 mmHg, a SBP goal of <120 mmHg reduced the primary endpoint of myocardial infarction, other acute coronary syndrome, stroke, heart failure, or cardiovascular death by 34% (p = 0.001), all-cause mortality by 33% (p = 0...
August 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/28741156/response-to-the-letter-from-landman-et-al
#16
REVIEW
Reuven Zimlichman
No abstract text is available yet for this article.
August 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/28735433/comments-on-cernes-r-zimlichman-r-role-of-paced-breathing-for-treatment-of-hypertension-curr-hypertens-rep-2017-19-45
#17
REVIEW
Gijs W D Landman, Kornelis J J van Hateren, Nanne Kleefstra
No abstract text is available yet for this article.
August 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/28717886/endoplasmic-reticulum-stress-a-driver-or-an-innocent-bystander-in-endothelial-dysfunction-associated-with-hypertension
#18
REVIEW
Robyn Cunard
PURPOSE OF REVIEW: Hypertension (htn) is a polygenic disorder that effects up to one third of the US population. The endoplasmic reticulum (ER) stress response is a homeostatic pathway that regulates membrane structure, protein folding, and secretory function. Emerging evidence suggests that ER stress may induce endothelial dysfunction; however, it is unclear whether ER stress-associated endothelial dysfunction modulates htn. RECENT FINDINGS: Exogenous and endogenous molecules activate ER stress in the endothelium, and ER stress mediates some forms of neurogenic htn, such as angiotensin II-dependent htn...
August 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/28707234/the-elusive-search-for-optimal-blood-pressure-targets
#19
REVIEW
Alan H Gradman
BP treatment thresholds/targets determine when to initiate treatment and to what level BP should be reduced. The Seventh Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC-7) recommended a target of <140/90 for most patients and a target <130/80 mmHg for patients with diabetes or chronic kidney disease. Subsequently, meta-analyses, retrospective studies relating on-treatment BP to clinical outcomes and two large, randomized clinical trials (RCTs) have re-evaluated BP targets...
August 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/28695400/role-of-collecting-duct-renin-in-the-pathogenesis-of-hypertension
#20
REVIEW
Alexis A Gonzalez, Lucienne S Lara, Minolfa C Prieto
The presence of renin production by the principal cells of the collecting duct has opened new perspectives for the regulation of intrarenal angiotensin II (Ang II). Angiotensinogen (AGT) and angiotensin-converting enzyme (ACE) are present in the tubular fluid coming from the proximal tubule and collecting duct. All the components needed for Ang II formation are present along the nephron, and much is known about the mechanisms regulating renin in juxtaglomerular cells (JG); however, those in the collecting duct remain unclear...
August 2017: Current Hypertension Reports
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