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Current Hypertension Reports

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https://www.readbyqxmd.com/read/28785887/quality-of-meta-analyses-for-randomized-trials-in-the-field-of-hypertension-an-updated-and-improved-systematic-review
#1
REVIEW
George C Roush, Fiorella Perez, Ramy Abdelfattah, Andrew Prindle, Elie Jean, Tanveer Singh, John B Kostis, William J Kostis, William J Elliott, Jesse A Berlin
Publications of hypertension-related meta-analyses (MAs) have increased exponentially in the past 25 years and now average 8/month. Theoretically, this is facilitating evidence-based management of patients. However, some practitioners and authors of guidelines have questioned the quality of published MAs. By extending a prior review, we have assessed the quality of 212 hypertension-related meta-analyses over 5 years based on systematically searching three computerized libraries. Seventeen criteria grouped into four domains of quality yielded the following results: (1) Assessment of trial quality was accomplished in 89% of MAs, and 38% analyzed trials in subgroups of trial quality where appropriate...
September 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/28780627/primary-pediatric-hypertension-current-understanding-and-emerging-concepts
#2
REVIEW
Andrew C Tiu, Michael D Bishop, Laureano D Asico, Pedro A Jose, Van Anthony M Villar
The rising prevalence of primary pediatric hypertension and its tracking into adult hypertension point to the importance of determining its pathogenesis to gain insights into its current and emerging management. Considering that the intricate control of BP is governed by a myriad of anatomical, molecular biological, biochemical, and physiological systems, multiple genes are likely to influence an individual's BP and susceptibility to develop hypertension. The long-term regulation of BP rests on renal and non-renal mechanisms...
September 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/28770533/hyperuricemia-type-2-diabetes-mellitus-and-hypertension-an-emerging-association
#3
REVIEW
Ibrahim Mortada
Uric acid is the final oxidation product of purine metabolism in circulation and has been associated with the occurrence of gout and kidney stones. Type 2 diabetes mellitus and hypertension are two important public health challenges, and both are linked to increased risk of cardiovascular events. Hyperuricemia has recently emerged as an independent risk factor in the development of type 2 diabetes mellitus and hypertension through several proposed mechanisms. Few clinical trials investigated the use of uric acid lowering agents in the management of these two disease entities; however, their results provided encouraging evidence to a potential role for these agents in fighting disease burden...
September 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/28755274/regression-of-left-ventricular-mass-after-bariatric-surgery
#4
REVIEW
Thierry H Le Jemtel, Rohan Samson, Abhishek Jaiswal, Eliza B Lewine, Suzanne Oparil
Notwithstanding the presence of hypertension, obstructive sleep apnea, or both, obesity is associated with increased left ventricular (LV) mass. The effects of bariatric surgery on LV mass have been sparsely investigated by M-mode and two-dimensional (2D) echocardiography. Overall, Roux-en-Y gastric bypass, adjustable gastric banding, and sleeve gastrectomy reduce LV mass. However, the reduction in LV mass is extremely variable. Besides duration and severity of obesity, presence of hypertension, obstructive sleep apnea or both, and type of surgical procedures, the inaccuracy of M-mode and 2D echocardiography for assessment of LV mass contributes to the variable effects of bariatric surgery on LV mass...
September 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/28801878/pulse-waveform-analysis-is-it-ready-for-prime-time
#5
REVIEW
Bernhard Hametner, Siegfried Wassertheurer
PURPOSE OF REVIEW: Arterial pulse waveform analysis has a long tradition but has not pervaded medical routine yet. This review aims to answer the question whether the methodology is ready for prime time use. The current methodological consensus is assessed, existing technologies for waveform measurement and pulse wave analysis are discussed, and further needs for a widespread use are proposed. RECENT FINDINGS: A consensus document on the understanding and analysis of the pulse waveform was published recently...
August 11, 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/28791529/effects-of-raas-inhibitors-in-patients-with-kidney-disease
#6
REVIEW
Fan Zhang, Hong Liu, Di Liu, Yexin Liu, Huiqiong Li, Xia Tan, Fuyou Liu, Youming Peng, Hongqing Zhang
Proteinuria and decline of renal function are associated with progression of kidney disease. The Renin Angiotensin Aldosterone System (RAAS) plays an important role in blood pressure regulation, fluid volume, and sodium balance. Overactivity of RAAS contributes to the pathogenesis of a variety of clinical conditions including progress of chronic kidney disease (CKD). This review summarizes the use of RAAS inhibitors as dual therapy or monotherapy in different stages of kidney disease. Experimental and clinical studies have demonstrated RAAS inhibitors prevent proteinuria, kidney fibrosis and slow decline of renal function and thus play a protective role in both early and end stages of kidney disease...
August 8, 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/28755159/managing-hypertension-in-the-elderly-what-is-different-what-is-the-same
#7
REVIEW
Wilbert S Aronow
PURPOSE OF REVIEW: The goal is to discuss management of hypertension in the elderly. RECENT FINDINGS: At 3.14-year follow-up of 2636 persons ≥75 years in the Systolic Blood Pressure Intervention Trial (SPRINT), compared with a systolic blood pressure (SBP) goal of <140 mmHg, a SBP goal of <120 mmHg reduced the primary endpoint of myocardial infarction, other acute coronary syndrome, stroke, heart failure, or cardiovascular death by 34% (p = 0.001), all-cause mortality by 33% (p = 0...
August 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/28741156/response-to-the-letter-from-landman-et-al
#8
REVIEW
Reuven Zimlichman
No abstract text is available yet for this article.
August 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/28735433/comments-on-cernes-r-zimlichman-r-role-of-paced-breathing-for-treatment-of-hypertension-curr-hypertens-rep-2017-19-45
#9
REVIEW
Gijs W D Landman, Kornelis J J van Hateren, Nanne Kleefstra
No abstract text is available yet for this article.
August 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/28717886/endoplasmic-reticulum-stress-a-driver-or-an-innocent-bystander-in-endothelial-dysfunction-associated-with-hypertension
#10
REVIEW
Robyn Cunard
PURPOSE OF REVIEW: Hypertension (htn) is a polygenic disorder that effects up to one third of the US population. The endoplasmic reticulum (ER) stress response is a homeostatic pathway that regulates membrane structure, protein folding, and secretory function. Emerging evidence suggests that ER stress may induce endothelial dysfunction; however, it is unclear whether ER stress-associated endothelial dysfunction modulates htn. RECENT FINDINGS: Exogenous and endogenous molecules activate ER stress in the endothelium, and ER stress mediates some forms of neurogenic htn, such as angiotensin II-dependent htn...
August 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/28707234/the-elusive-search-for-optimal-blood-pressure-targets
#11
REVIEW
Alan H Gradman
BP treatment thresholds/targets determine when to initiate treatment and to what level BP should be reduced. The Seventh Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC-7) recommended a target of <140/90 for most patients and a target <130/80 mmHg for patients with diabetes or chronic kidney disease. Subsequently, meta-analyses, retrospective studies relating on-treatment BP to clinical outcomes and two large, randomized clinical trials (RCTs) have re-evaluated BP targets...
August 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/28695400/role-of-collecting-duct-renin-in-the-pathogenesis-of-hypertension
#12
REVIEW
Alexis A Gonzalez, Lucienne S Lara, Minolfa C Prieto
The presence of renin production by the principal cells of the collecting duct has opened new perspectives for the regulation of intrarenal angiotensin II (Ang II). Angiotensinogen (AGT) and angiotensin-converting enzyme (ACE) are present in the tubular fluid coming from the proximal tubule and collecting duct. All the components needed for Ang II formation are present along the nephron, and much is known about the mechanisms regulating renin in juxtaglomerular cells (JG); however, those in the collecting duct remain unclear...
August 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/28689331/pathophysiology-and-current-clinical-management-of-preeclampsia
#13
REVIEW
Lorena M Amaral, Kedra Wallace, Michelle Owens, Babbette LaMarca
Preeclampsia is characterized by blood pressure greater than 140/90 mmHg in the second half of pregnancy. This disease is a major contributor to preterm and low birth weight babies. The early delivery of the baby, which becomes necessary for maintaining maternal well-being, makes preeclampsia the leading cause for preterm labor and infant mortality and morbidity. Currently, there is no cure for this pregnancy disorder. The current clinical management of PE is hydralazine with labetalol and magnesium sulfate to slow disease progression and prevent maternal seizure, and hopefully prolong the pregnancy...
August 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/28676941/molecular-mechanisms-of-sodium-sensitive-hypertension-in-the-metabolic-syndrome
#14
REVIEW
Jonathan M Nizar, Vivek Bhalla
PURPOSE OF REVIEW: We review the known mechanisms of sodium-sensitive hypertension in the metabolic syndrome with a focus on preclinical models, differences between these models, and methodological limitations. We also identify future directions for a better understanding and treatment of this common condition. RECENT FINDINGS: Rigorous methodologies to measure blood pressure in preclinical models may clarify some of the inconsistencies in the literature. Renal, neural, hormonal, and cardiovascular systems are dysregulated and contribute to elevated blood pressure...
August 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/28620841/device-based-approaches-for-the-treatment-of-arterial-hypertension
#15
REVIEW
Jens Jordan
Device-based antihypertensive treatments have primarily been developed and clinically tested for patients with hypertension refractory to pharmacological treatment. Most but not all device-based treatments target the sympathetic nervous system and provided important new insight in the mechanisms of human hypertension. This review provides an overview on the scientific rational and clinical data on recent device-based antihypertensive treatment approaches. Device-based treatments targeting the sympathetic nervous system include catheter-based renal nerve ablation, electrical carotid sinus stimulation, modulation of baroreflex transduction through a dedicated carotid stent, carotid body denervation, and deep brain stimulation...
July 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/28597405/hyperbilirubinemia-hypertension-and-ckd-the-links
#16
REVIEW
Ibrahim Mortada
PURPOSE OF REVIEW: This review aims to highlight recent advances on the role of hyperbilirubinemia in hypertension and chronic kidney disease, with a focus on the pathophysiological mechanisms explaining the protective effects of bilirubin. An overview of pharmacologic induction of hyperbilirubinemia will also be discussed. RECENT FINDINGS: The findings depict a protective role of bilirubin in the development of hypertension and cardiovascular diseases. Hyperbilirubinemia is also negatively correlated with the development and progression of chronic kidney disease...
July 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/28597404/relevance-of-microrna-21-in-different-types-of-hypertension
#17
REVIEW
Durairaj Sekar, B R Shilpa, Anupam J Das
Hypertension (HTN) is a chronic medical condition that commonly affects the aging population worldwide. The prevalence of HTN is increasing in developing countries and is one of the leading causes of death in older individuals. HTN results from a complex interplay of genetic and environmental factors. Besides, HTN can result in various other health complications such as stroke and chronic kidney diseases, if not treated. Although various studies have explained the underlying mechanisms in the pathogenesis of HTN, limited information is available on their biomarkers...
July 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/28597403/resistant-hypertension-mechanisms-and-treatment
#18
REVIEW
Andrew Y Hwang, Eric Dietrich, Carl J Pepine, Steven M Smith
PURPOSE OF REVIEW: Emerging evidence suggests that multiple mechanisms may be responsible for the development of treatment-resistant hypertension (TRH). This review aims to summarize recent data on potential mechanisms of resistance and discuss current pharmacotherapeutic options available in the management of TRH. RECENT FINDINGS: Excess sodium and fluid retention, increased activation of the renin-angiotensin-aldosterone system, and heightened activity of the sympathetic nervous system appear to play an important role in development of TRH...
July 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/28593612/an-obesity-paradox-increased-body-mass-index-is-associated-with-decreased-aortic-atherosclerosis
#19
REVIEW
Rolf F Barth, L Maximilian Buja, Lei Cao, Sergey V Brodsky
Brodsky et al. (Cardiovasc Pathol 25(6), 515-520, 2016) recently have reported that there was an unexpected and highly significant inverse correlation between body mass index (BMI) and atherosclerosis of the aortas of morbidly obese decedents (BMI >40 kg/m(2)). In a series of 304 decedents, 65 of whom were morbidly obese, minimal or no atherosclerosis was seen in 46 of them (70%) versus 20 (30%) who had severe atherosclerosis (P = 0.008). This obesity paradox was unexpected and raises important questions about the etiology and pathogenesis of atherosclerosis, which will be the subject of this commentary...
July 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/28551831/clinical-implications-of-different-blood-pressure-measurement-techniques
#20
REVIEW
Paul Drawz
PURPOSE OF REVIEW: The appropriate treatment targets for individuals with elevated blood pressure (BP) have received increased attention in light of recent clinical trial results. However, it is well known that the method used to measure BP can have a significant impact on the observed BP. In this review, we summarize the existing literature on the impact of BP measurement technique on observed BP readings. RECENT FINDINGS: Manual BPs obtained in-clinic routinely differ from those obtained using automated devices...
July 2017: Current Hypertension Reports
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