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Current Hypertension Reports

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https://www.readbyqxmd.com/read/29779164/update-on-endothelin-receptor-antagonists-in-hypertension
#1
REVIEW
Michel Burnier
To review the most recent data on the development of endothelin receptor antagonists (ERAs) for the treatment of hypertension and the management of diabetic nephropathy RECENT FINDINGS: Recent reviews and meta-analyses of experimental and clinical data obtained with ERAs confirmed that endothelin receptor blockade is associated with significant decreases in blood pressure in essential hypertension but also in resistant hypertension. In addition, in patients with diabetic nephropathy, ERAs induce significant 30-40% decreases in albuminuria when administered on top of blockers of the renin-angiotensin system...
May 19, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/29779139/insomnia-short-sleep-duration-and-high-blood-pressure-recent-evidence-and-future-directions-for-the-prevention-and-management-of-hypertension
#2
REVIEW
Christina J Bathgate, Julio Fernandez-Mendoza
PURPOSE OF REVIEW: To summarize research from the past 2 years on the association between insomnia, short sleep duration, and hypertension and provide a critical analysis of the evidence and suggestions for future directions in this field. RECENT FINDINGS: Evidence indicates that the association between insomnia and elevated blood pressure (BP) or stage 1 and 2 hypertension is stronger in those with chronic insomnia, as compared to those with isolated insomnia symptoms, and primarily found in those with the insomnia with objective short sleep duration phenotype...
May 19, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/29779124/confidenht%C3%A2-system-for-diagnostic-mapping-of-renal-nerves
#3
REVIEW
Costas Tsioufis, Kyriakos Dimitriadis, Panagiotis Tsioufis, Rafael Patras, Maria Papadoliopoulou, Zoi Petropoulou, Dimitris Konstantinidis, Dimitrios Tousoulis
PURPOSE OF REVIEW: To summarize the evidence regarding the distribution of renal nerves and their patterns of anatomic variations in animal and human settings. Moreover, the methodology and results of studies regarding renal nerve stimulation (RNS) in both preclinical and clinical models are presented. RECENT FINDINGS: There are differences regarding the number and the size of renal fibers, as well as their distance from the lumen in the diverse parts of the main renal arteries and the branches...
May 19, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/29779058/genetics-of-resistant-hypertension-the-missing-heritability-and-opportunities
#4
REVIEW
Samantha K Teixeira, Alexandre C Pereira, Jose E Krieger
PURPOSE OF THE REVIEW: Blood pressure regulation in humans has long been known to be a genetically determined trait. The identification of causal genetic modulators for this trait has been unfulfilling at the least. Despite the recent advances of genome-wide genetic studies, loci associated with hypertension or blood pressure still explain a very low percentage of the overall variation of blood pressure in the general population. This has precluded the translation of discoveries in the genetics of human hypertension to clinical use...
May 19, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/29779054/dietary-modifications-and-lipid-accumulation-product-are-associated-with-systolic-and-diastolic-blood-pressures-in-the-women-s-health-trial-feasibility-study-in-minority-populations
#5
REVIEW
Alok Bhargava
PURPOSE OF REVIEW: Approximately 65% of adults over 60 years in the USA are hypertensive. Poor dietary habits and sedentary lifestyles are fueling the hypertension epidemic. The effects of higher intakes of fruits and vegetables and whole-grain products on systolic and diastolic blood pressures were analyzed using data at baseline, 6 months, and 12 months on 349 and 573 subjects, respectively, in the control and intervention groups of the Women's Health Trial: Feasibility Study in Minority Populations...
May 19, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/29754183/correction-to-dimerization-of-at-2-and-mas-receptors-in-control-of-blood-pressure
#6
Sanket Patel, Tahir Hussain
In the original publication, the Fig. 1 caption contains an error. The original article has been corrected.
May 12, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/29744660/anti-inflammatory-effects-of-melatonin-in-obesity-and-hypertension
#7
REVIEW
Natalia Jorgelina Prado, León Ferder, Walter Manucha, Emiliano Raúl Diez
PURPOSE OF REVIEW: Here, we review the known relations between hypertension and obesity to inflammation and postulate the endogenous protective effect of melatonin and its potential as a therapeutic agent. We will describe the multiple effects of melatonin on blood pressure, adiposity, body weight, and focus on mitochondrial-related anti-inflammatory and antioxidant protective effects. RECENT FINDINGS: Hypertension and obesity are usually associated with systemic and tissular inflammation...
May 9, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/29744599/endovascular-baroreflex-amplification-for-resistant-hypertension
#8
REVIEW
Monique E A M van Kleef, Mark C Bates, Wilko Spiering
PURPOSE OF REVIEW: Most hypertension devices have been designed to interrupt or modify the sympathetic nervous system, which seems to be unbalanced in hypertension. Carotid baroreceptors play a pivotal role in maintaining adrenergic balance via a direct feedback interface and would be an exceptional target for intervention. The purpose of this review is to define the role of the baroreceptor in hypertension, to examine device-based therapies targeting the baroreflex and to explore future promises of endovascular baroreflex amplification (EBA)...
May 9, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/29736674/modulation-of-vascular-reactivity-by-perivascular-adipose-tissue-pvat
#9
REVIEW
Claudia Agabiti-Rosei, Anna Paini, Carolina De Ciuceis, Sarah Withers, Adam Greenstein, Anthony M Heagerty, Damiano Rizzoni
PURPOSE OF REVIEW: In this review, we discuss the role of perivascular adipose tissue (PVAT) in the modulation of vascular contractility and arterial pressure, focusing on the role of the renin-angiotensin-aldosterone system and oxidative stress/inflammation. RECENT FINDINGS: PVAT possesses a relevant endocrine-paracrine activity, which may be altered in several pathophysiological and clinical conditions. During the last two decades, it has been shown that PVAT may modulate vascular reactivity...
May 7, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/29730779/the-role-of-circadian-rhythms-in-the-hypertension-of-diabetes-mellitus-and-the-metabolic-syndrome
#10
REVIEW
Björn Lemmer, Henrik Oster
PURPOSE OF THE REVIEW: Cellular circadian clocks regulate physiological functions during day and night. It has been convincingly demonstrated that hypertension in patients suffering from diabetes mellitus or metabolic syndrome is characterized in most cases by a disturbed 24-h profile resulting in a nondipper pattern. We consider possible correlation between biological clocks and symptoms of the metabolic syndrome. RECENT FINDINGS: Changes in circadian clock function have been linked to metabolic disorders in genome-wide association studies...
May 5, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/29717393/hypertension-in-developing-countries-a-major-challenge-for-the-future
#11
REVIEW
M Mohsen Ibrahim
PURPOSE OF REVIEW: Outline recent epidemiologic data regarding hypertension in developing countries, distinguish differences from developed countries, and identify challenges in management and future perspectives. RECENT FINDINGS: Increased sugar intake, air and noise pollution, and low birth weight are emerging hypertension risk factors. The major challenges in management are difficulties in accurate diagnosis of hypertension and adequate blood pressure control...
May 1, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/29717392/arterial-distensibility-physical-activity-and-the-metabolic-syndrome
#12
REVIEW
Francesca Saladini, Paolo Palatini
PURPOSE OF REVIEW: Metabolic syndrome (MetS), a cluster of risk factors including central obesity, metabolic abnormalities, and arterial hypertension, is a well-known determinant of arterial wall remodeling and stiffening. The mechanisms whereby MetS promotes arterial stiffening include increased sympathetic activity with the associated fast heart rate, enhanced activity of the renin-angiotensin-aldosterone system, increased production of inflammatory cytokines and reactive oxygen species, and reduction of nitric oxide availability...
May 1, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/29717388/dimerization-of-at-2-and-mas-receptors-in-control-of-blood-pressure
#13
REVIEW
Sanket Patel, Tahir Hussain
PURPOSE OF REVIEW: Angiotensin type 2 receptor (AT2 R) and receptor Mas (MasR) are part of the "protective arm" of the renin angiotensin system. Gene and pharmacological manipulation studies reveal that AT2 R and MasR are involved in natriuretic, vasodilatory, and anti-inflammatory responses and in lowering blood pressure in various animal models under normal and pathological conditions such as salt-sensitive hypertension, obesity, and diabetes. The scope of this review is to discuss co-localization and heterodimerization as potential molecular mechanisms of AT2 R- and MasR-mediated functions including antihypertensive activities...
May 1, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/29717384/the-complement-alternative-pathway-and-preeclampsia
#14
REVIEW
Layan Alrahmani, Maria Alice V Willrich
PURPOSE OF REVIEW: Significant and intricate immune adaptations are essential for the establishment and maintenance of normal pregnancy. Preeclampsia is a morbid, potentially life-threatening disease for both mother and neonate that occurs uniquely in pregnancy, at least in part, due to maternal immune maladaptation. We aim to review the literature that focuses on case reports, diagnostic approaches, and treatment strategies for disorders of the complement alternative pathway (CAP) as related to preeclampsia...
May 1, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/29717380/selective-vs-global-renal-denervation-a-case-for-less-is-more
#15
REVIEW
Marat Fudim, Asher A Sobotka, Yue-Hui Yin, Joanne W Wang, Howard Levin, Murray Esler, Jie Wang, Paul A Sobotka
PURPOSE OF REVIEW: Review the renal nerve anatomy and physiology basics and explore the concept of global vs. selective renal denervation (RDN) to uncover some of the fundamental limitations of non-targeted renal nerve ablation and the potential superiority of selective RDN. RECENT FINDINGS: Recent trials testing the efficacy of RDN showed mixed results. Initial investigations targeted global RDN as a therapeutic goal. The repeat observation of heterogeneous response to RDN including non-responders with lack of a BP reduction, or even more unsettling, BP elevations after RDN has raised concern for the detrimental effects of unselective global RDN...
May 1, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/29717377/a-systematic-review-of-sleep-hypertension-and-cardiovascular-risk-in-children-and-adolescents
#16
REVIEW
Aaron D Fobian, Lindsey Elliott, Tinnie Louie
PURPOSE OF REVIEW: Many of the risk factors for heart disease have recently been shown to develop during childhood such as left ventricular hypertrophy and fibrous plaque lesions. As risk for cardiovascular disease in children and adolescents has risen, sleep duration has decreased, and inadequate sleep in children and adolescents has been found to be associated with cardiovascular disease risk. The aims of this manuscript are to provide an updated systematic review of the literature assessing sleep, hypertension, and cardiovascular risk and evaluate the strength of the evidence based on the available research...
May 1, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/29713810/the-role-of-interleukin-10-in-the-pathophysiology-of-preeclampsia
#17
REVIEW
Hajrunisa Cubro, Sonu Kashyap, Meryl C Nath, Allan W Ackerman, Vesna D Garovic
PURPOSE OF REVIEW: The pathophysiology of preeclampsia is complex and not entirely understood. A key feature in preeclampsia development is an immunological imbalance that shifts the maternal immune response from one of tolerance towards one promoting chronic inflammation and endothelial dysfunction. As a key regulator of immunity, IL-10 not only has immunomodulatory activity, but also directly benefits vasculature and promotes successful cellular interactions at the maternal-fetal interface...
April 30, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/29637445/atherosclerotic-renal-artery-stenosis-should-we-intervene-earlier
#18
REVIEW
Peter W de Leeuw, Cor T Postma, Wilko Spiering, Abraham A Kroon
PURPOSE OF REVIEW: Randomized trials have failed to show clinical benefit in patients with atherosclerotic renal artery stenosis who were treated with angioplasty with or without stenting. However, these studies were done in patients with a high-grade stenosis. This paper examines whether there are arguments to consider patients with low-grade stenosis for angioplasty. RECENT FINDINGS: Patients with low-grade (< 50%) atherosclerotic renal artery stenosis have an excess risk for cardiovascular and renal complications...
April 10, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/29637419/the-endothelin-system-a-critical-player-in-the-pathophysiology-of-preeclampsia
#19
REVIEW
Joey P Granger, Frank T Spradley, Bhavisha A Bakrania
PURPOSE OF REVIEW: Preeclampsia (PE) is a disorder of pregnancy typically characterized by new-onset hypertension and proteinuria after gestational week 20. Although preeclampsia is one of the leading causes of maternal and perinatal morbidity and death worldwide, the mechanisms of the pathogenesis of the disorder remain unclear and treatment options are limited. Placental ischemic events and the release of placental factors appear to play a critical role in the pathophysiology. These factors contribute to a generalized systemic vascular endothelial dysfunction and result in increased systemic vascular resistance and hypertension...
April 10, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/29637415/clinical-and-molecular-features-of-thiazide-induced-hyponatremia
#20
REVIEW
Jodie Nadal, Sarath K Channavajjhala, Wenjing Jia, Jenny Clayton, Ian P Hall, Mark Glover
PURPOSE OF REVIEW: Hypertension affects more than 30% of the world's adult population and thiazide (and thiazide-like) diuretics are amongst the most widely used, effective, and least costly treatments available, with all-cause mortality benefits equivalent to angiotensin-converting enzyme inhibitors or calcium channel antagonists. A minority of patients develop thiazide-induced hyponatremia (TIH) and this is largely unpredictable at the point of thiazide prescription. In some cases, TIH can cause debilitating symptoms and require hospital admission...
April 10, 2018: Current Hypertension Reports
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