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Current Rheumatology Reports

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https://www.readbyqxmd.com/read/29754330/gender-differences-in-axial-spondyloarthritis-women-are-not-so-lucky
#1
REVIEW
T Rusman, R F van Vollenhoven, I E van der Horst-Bruinsma
PURPOSE OF REVIEW: Ankylosing spondylitis (AS) was historically seen as a predominantly male disease. However, more recent data showed a more homogenous sex prevalence. Unfortunately, in many studies in axial spondyloarthritis (axSpA), the number of women included is low and the analyses are often not stratified for gender distribution. The purpose of this review is to aggregate the existing data on gender differences in axSpA in order to increase the awareness that female axSpA patients are still under-recognized...
May 12, 2018: Current Rheumatology Reports
https://www.readbyqxmd.com/read/29725880/new-trials-in-lupus-and-where-are-we-going
#2
REVIEW
Aikaterini Thanou, Joan T Merrill
PURPOSE OF REVIEW: To review progress in the field of clinical trials for SLE. RECENT FINDINGS: Treatment development for SLE has been marked by failures of many later phase studies, representing billions of dollars of lost research and development funding. Recently, more successful Phase II trials have tested reductions in background medications, novel stringent endpoints, and identification of informative immunologic subsets to achieve greater treatment effects...
May 3, 2018: Current Rheumatology Reports
https://www.readbyqxmd.com/read/29713837/current-options-and-emerging-biomaterials-for-periprosthetic-joint-infection
#3
REVIEW
Ashley E Levack, Erika L Cyphert, Mathias P Bostrom, Christopher J Hernandez, Horst A von Recum, Alberto V Carli
PURPOSE OF REVIEW: Infection in the setting of total joint arthroplasty, referred to as periprosthetic joint infection (PJI), is a devastating complication requiring prolonged and costly treatment. The unique environment around an artificial joint and ability of surrounding tissues to sequester bacteria collectively make prevention, diagnosis, and treatment of this condition challenging. In light of the unique pathogenesis of PJI, this review explores the limitations of contemporary treatments and discusses novel treatment options...
April 30, 2018: Current Rheumatology Reports
https://www.readbyqxmd.com/read/29679241/therapeutic-approaches-to-type-i-interferonopathies
#4
REVIEW
Marc Bienias, Normi Brück, Constanze Griep, Christine Wolf, Stefanie Kretschmer, Barbara Kind, Victoria Tüngler, Reinhard Berner, Min Ae Lee-Kirsch
To review recent scientific advances and therapeutic approaches in the expanding field of type I interferonopathies. Type I interferonopathies represent a genetically and phenotypically heterogenous group of disorders of the innate immune system caused by constitutive activation of antiviral type I interferon (IFN). Clinically, type I interferonopathies are characterized by autoinflammation and varying degrees of autoimmunity or immunodeficiency. The elucidation of the underlying genetic causes has revealed novel cell-intrinsic mechanisms that protect the organism against inappropriate immune recognition of self nucleic acids by cytosolic nucleic acid sensors...
April 20, 2018: Current Rheumatology Reports
https://www.readbyqxmd.com/read/29675606/therapy-for-cppd-options-and-evidence
#5
REVIEW
Mariano Andrés, Francisca Sivera, Eliseo Pascual
PURPOSE OF REVIEW: Current evidence and accumulated experience for the management of calcium pyrophosphate deposition disease (CPPD) are presented. RECENT FINDINGS: Contrary to other rheumatic inflammatory conditions that account for high interest and growing research, advances in treating CPPD are still very limited and mostly derive from those achieved in gout. Once formed, calcium pyrophosphate crystals cannot be dissolved; therefore, management relies on the control of crystal-derived inflammation...
April 19, 2018: Current Rheumatology Reports
https://www.readbyqxmd.com/read/29663162/functional-defects-of-treg-cells-new-targets-in-rheumatic-diseases-including-ankylosing-spondylitis
#6
REVIEW
Jinlin Miao, Ping Zhu
PURPOSE OF REVIEW: This study aims to review the advances of Treg cell biology, the functional defects of Treg cells, and the potential strategies for the experimental, preclinical or clinical application of Treg cell therapy in the context of autoimmune/immune-mediated rheumatic diseases. RECENT FINDINGS: CD4+ CD25+ regulatory T (Treg) cells are a phenotypically and functionally heterogeneous subset of lymphocytes that prevent a variety of autoimmune diseases. As in many autoimmune diseases, the functional defects of Treg cells are supposed to play relevant roles in the pathogenesis and development of systemic lupus erythematosus, rheumatoid arthritis, ankylosing spondylitis, and other autoimmune/immune-mediated rheumatic diseases...
April 16, 2018: Current Rheumatology Reports
https://www.readbyqxmd.com/read/29637414/dermatomyositis-clinical-and-pathological-phenotypes-associated-with-myositis-specific-autoantibodies
#7
REVIEW
Paige W Wolstencroft, David F Fiorentino
PURPOSE OF REVIEW: Dermatomyositis is an idiopathic inflammatory myopathy with a variety of systemic and cutaneous manifestations. The myositis-specific autoantibodies (MSAs) are associated with phenotypic features and provide a tool for sub-classification of dermatomyositis patients. This review focuses on recent work characterizing the clinical features that accompany the MSAs in dermatomyositis. RECENT FINDINGS: There is increasing recognition of the distinct clinical and pathological phenotypes associated with each MSA...
April 10, 2018: Current Rheumatology Reports
https://www.readbyqxmd.com/read/29637406/innovative-research-design-to-meet-the-challenges-of-clinical-trials-for-juvenile-dermatomyositis
#8
REVIEW
Silvia Rosina, Giulia Camilla Varnier, Marta Mazzoni, Stefano Lanni, Clara Malattia, Angelo Ravelli
PURPOSE OF REVIEW: This paper aims to provide a summary of the recent therapeutic advances and the latest research on outcome measures for clinical trials in juvenile dermatomyositis (JDM). RECENT FINDINGS: Recent randomized controlled trials (RCTs) have demonstrated the superiority of the combination of prednisone with methotrexate over other conventional therapies and the potential effectiveness of rituximab in refractory cases. A multinational project has led to develop new criteria for the definition of minimal, moderate, and major improvement in future JDM clinical trials...
April 10, 2018: Current Rheumatology Reports
https://www.readbyqxmd.com/read/29637383/management-of-interstitial-lung-disease-in-patients-with-myositis-specific-autoantibodies
#9
REVIEW
Christopher A Mecoli, Lisa Christopher-Stine
PURPOSE OF REVIEW: To review advances in the management of idiopathic inflammatory myopathy-associated interstitial lung disease (IIM-associated ILD) in the past 5 years, with highlights in myositis-specific antibody (MSA) groups. RECENT FINDINGS: With the recent advent of widespread MSA testing, the study of specific homogeneous autoantibody-based subgroups of IIM-associated ILD is now possible. The prevalence, severity, prognosis, and response to treatment are under study for these individual MSAs...
April 10, 2018: Current Rheumatology Reports
https://www.readbyqxmd.com/read/29611059/new-developments-in-the-genetics-of-inclusion-body-myositis
#10
REVIEW
Kyla A Britson, Stephanie Y Yang, Thomas E Lloyd
PURPOSE OF REVIEW: Our goal is to review the recent literature pertaining to the genetics of sporadic inclusion body myositis (IBM). RECENT FINDINGS: In a study of 252 IBM patients, the class II MHC allele HLA-DRB1*03:01 showed the most significant association with IBM, and that risk could be largely attributed to amino acids within the peptide-binding pocket. Candidate gene sequencing identified rare missense variants in proteins regulating protein homeostasis including VCP and SQSTM1...
April 2, 2018: Current Rheumatology Reports
https://www.readbyqxmd.com/read/29611051/iga-vasculitis-genetics-and-clinical-and-therapeutic-management
#11
REVIEW
Miguel A González-Gay, Raquel López-Mejías, Trinitario Pina, Ricardo Blanco, Santos Castañeda
PURPOSE OF REVIEW: The purpose of the study is to perform an update on the current knowledge on genetics, clinical manifestations, and therapy in immunoglobulin A vasculitis (IgAV) (Henoch-Schönlein purpura). RECENT FINDINGS: A strong genetic predisposition in individuals with IgAV was confirmed. It was due to the association with the HLA class II region that in people of European background is mainly related to HLA-DRB1*01 allele. Recent reports support the claim that kidney disease is more common in adults than in children with IgAV...
April 2, 2018: Current Rheumatology Reports
https://www.readbyqxmd.com/read/29611005/recent-advances-in-giant-cell-arteritis
#12
REVIEW
M Guevara, C S Kollipara
PURPOSE OF REVIEW: Giant cell arteritis (GCA) is the most common systemic vasculitis. GCA is categorized as a granulomatous vasculitis of large and medium size vessels. Majority of the symptoms and signs of GCA result from involvement of the aorta and its branches intra- and extracranial. Temporal artery biopsy continues to be the cardinal diagnostic procedure despite new imaging modalities for diagnosing GCA with cranial involvement. Great advances in awareness have led to improvement in preventing irreversible vision loss due to early diagnosis...
April 2, 2018: Current Rheumatology Reports
https://www.readbyqxmd.com/read/29611001/eosinophilic-granulomatosis-with-polyangiitis-newer-therapies
#13
REVIEW
Erika P Navarro-Mendoza, Gabriel J Tobón
PURPOSE OF REVIEW: Eosinophilic granulomatosis with polyangiitis (EGPA) is a systemic disseminated vasculitis associated with extravascular granulomas in patients suffering from asthma and tissue eosinophilia. Current therapies to achieve remission and prevent relapse include glucocorticoids and immunosuppressants like cyclophosphamide. RECENT FINDINGS: With the right treatment, clinical prognosis is favorable, so concerted efforts have been made in recent years to find new alternatives for treating severe EGPA...
April 2, 2018: Current Rheumatology Reports
https://www.readbyqxmd.com/read/29582188/immune-mediated-necrotizing-myopathy
#14
REVIEW
Iago Pinal-Fernandez, Maria Casal-Dominguez, Andrew L Mammen
PURPOSE OF REVIEW: Immune-mediated necrotizing myopathy (IMNM) is a type of autoimmune myopathy characterized by relatively severe proximal weakness, myofiber necrosis with minimal inflammatory cell infiltrate on muscle biopsy, and infrequent extra-muscular involvement. Here, we will review the characteristics of patients with IMNM. RECENT FINDINGS: Anti-signal recognition particle (SRP) and anti-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) autoantibodies are closely associated with IMNM and define unique subtypes of patients...
March 26, 2018: Current Rheumatology Reports
https://www.readbyqxmd.com/read/29550994/sirtuins-and-accelerated-aging-in-scleroderma
#15
REVIEW
Anne E Wyman, Sergei P Atamas
PURPOSE OF REVIEW: Premature activation of aging-associated molecular mechanisms is emerging as an important contributor to many diseases, including scleroderma. Among central regulators of the aging process are a group of histone deacetylases called sirtuins (SIRTs). Recent findings implicate these molecules as pathophysiological players in scleroderma skin and lung fibrosis. The goal of this article is to review recent studies on the involvement of SIRTs in scleroderma from the perspective of aging-related molecular mechanisms...
March 17, 2018: Current Rheumatology Reports
https://www.readbyqxmd.com/read/29550993/patient-satisfaction-and-costs-of-multidisciplinary-models-of-care-in-rheumatology-a-review-of-the-recent-literature
#16
REVIEW
Jill Hall, K Julia Kaal, Junho Lee, Ross Duncan, Nicole Tsao, Mark Harrison
PURPOSE OF THE REVIEW: A number of novel models of care utilizing allied healthcare professionals, including nurses and pharmacists, have emerged as an alternate to rheumatologist specialist care to achieve disease outcomes in patients with inflammatory arthritis. We conducted a review of the literature for studies from the past 5 years that reported on measures of patient satisfaction and/or any health economic outcome in a model of care where the care providers had substantial, but not completely independent, responsibility...
March 17, 2018: Current Rheumatology Reports
https://www.readbyqxmd.com/read/29550962/macrophages-wound-healing-and-fibrosis-recent-insights
#17
REVIEW
Kate S Smigiel, William C Parks
PURPOSE OF REVIEW: Macrophages are central players in the immune response following tissue injury. These cells perform many functions, and the changing tissue microenvironment during injury shapes macrophage phenotype down a variety of polarized pathways. This review summarizes the current knowledge on the roles of macrophages during different stages of tissue injury, repair, and-if repair is not achieved-fibrosis. RECENT FINDINGS: Macrophages present early in inflammation are functionally distinct from those at later stages...
March 17, 2018: Current Rheumatology Reports
https://www.readbyqxmd.com/read/29550947/the-representation-of-gender-and-race-ethnic-groups-in-randomized-clinical-trials-of-individuals-with-systemic-lupus-erythematosus
#18
REVIEW
Titilola Falasinnu, Yashaar Chaichian, Michelle B Bass, Julia F Simard
PURPOSE OF REVIEW: This review evaluated gender and race/ethnic representation in randomized controlled trials (RCTs) of patients with systemic lupus erythematosus (SLE). RECENT FINDINGS: Whites comprise 33% of prevalent SLE cases and comprised 51% of RCT enrollees. Blacks encompass 43% of prevalent SLE cases, but only represented 14% of RCT enrollees. Hispanics comprise 16% of prevalent SLE cases and 21% of RCT enrollees, while Asians comprise 13% of prevalent SLE cases and 10% of RCT enrollees...
March 17, 2018: Current Rheumatology Reports
https://www.readbyqxmd.com/read/29550929/new-myositis-classification-criteria-what-we-have-learned-since-bohan-and-peter
#19
REVIEW
Valérie Leclair, Ingrid E Lundberg
PURPOSE OF REVIEW: Idiopathic inflammatory myopathy (IIM) classification criteria have been a subject of debate for many decades. Despite several limitations, the Bohan and Peter criteria are still widely used. The aim of this review is to discuss the evolution of IIM classification criteria. RECENT FINDINGS: New IIM classification criteria are periodically proposed. The discovery of myositis-specific and myositis-associated autoantibodies led to the development of clinico-serological criteria, while in-depth description of IIM morphological features improved histopathology-based criteria...
March 17, 2018: Current Rheumatology Reports
https://www.readbyqxmd.com/read/29541874/update-on-antiphospholipid-syndrome-ten-topics-in-2017
#20
REVIEW
Ilaria Cavazzana, Laura Andreoli, Maarteen Limper, Franco Franceschini, Angela Tincani
PURPOSE OF REVIEW: This review focuses on new clinical aspects of antiphospholipid syndrome (APS) in the last 5 years. RECENT FINDINGS: The pathogenesis of APS is related to endothelial activation by mechanisms other than autoantibody-mediated massive coagulation. These include Toll-like receptors, the m-TORC pathway, and neutrophil activation, inducing an uncontrolled inflammatory cascade. Given these new pathogenetic hypotheses, the treatment of APS could be directed towards a fine balance between anticoagulation and immunomodulation...
March 15, 2018: Current Rheumatology Reports
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