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Current Cardiology Reports

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https://www.readbyqxmd.com/read/29770888/mitral-valve-interventions-in-structural-heart-disease
#1
REVIEW
Matteo Saccocci, Maurizio Taramasso, Francesco Maisano
PURPOSE OF REVIEW: Analyze the current state of the art and the future perspectives of mitral interventions in clinical setting. RECENT FINDINGS: A systematic and critical review of the new mitral percutaneous therapies and imaging technologies is the basis to adopt the right treatment for each patient according to specific valve dysfunction and clinical presentation, waiting for definitive guidelines. While surgical mitral repair will remain the gold standard for low-risk healthy patients with degenerative mitral regurgitation (DMR), transcatheter mitral valve repair is becoming first line therapy in high risk patients with functional mitral regurgitation (FMR)...
May 17, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/29749590/imaging-health-record-and-artificial-intelligence-hype-or-hope
#2
REVIEW
Marco Mazzanti, Ervina Shirka, Hortensia Gjergo, Endri Hasimi
PURPOSE OF REVIEW: The review is focused on "digital health", which means advanced analytics based on multi-modal data. The "Health Care Internet of Things", which uses sensors, apps, and remote monitoring could provide continuous clinical information in the cloud that enables clinicians to access the information they need to care for patients everywhere. Greater standardization of acquisition protocols will be needed to maximize the potential gains from automation and machine learning...
May 10, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/29749577/the-various-applications-of-3d-printing-in-cardiovascular-diseases
#3
REVIEW
Abdallah El Sabbagh, Mackram F Eleid, Mohammed Al-Hijji, Nandan S Anavekar, David R Holmes, Vuyisile T Nkomo, Gustavo S Oderich, Stephen D Cassivi, Sameh M Said, Charanjit S Rihal, Jane M Matsumoto, Thomas A Foley
PURPOSE OF REVIEW: To highlight the various applications of 3D printing in cardiovascular disease and discuss its limitations and future direction. RECENT FINDINGS: Use of handheld 3D printed models of cardiovascular structures has emerged as a facile modality in procedural and surgical planning as well as education and communication. Three-dimensional (3D) printing is a novel imaging modality which involves creating patient-specific models of cardiovascular structures...
May 10, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/29736735/current-endovascular-approach-to-the-management-of-acute-ischemic-stroke
#4
REVIEW
Rakesh Khatri, Anantha R Vellipuram, Alberto Maud, Salvador Cruz-Flores, Gustavo J Rodriguez
PURPOSE OF REVIEW: The review provides an overview of current endovascular management of patients with acute ischemic stroke in the light of recent landmark trials proving unequivocal benefit of the intervention. RECENT FINDINGS: Several randomized trials looking at selective groups of patients presenting after an acute ischemic stroke due to large vessel occlusion in the anterior circulation demonstrated an overwhelming benefit of the endovascular treatment compared to intravenous thrombolysis, leading to expedited changes in the American Heart Association/American Stroke Association guidelines...
May 7, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/29730842/generation-of-human-pluripotent-stem-cell-derived-endothelial-cells-and-their-therapeutic-utility
#5
REVIEW
Shin-Jeong Lee, Kyung Hee Kim, Young-Sup Yoon
PURPOSE OF REVIEW: Human pluripotent stem cell-derived endothelial cells (hPSC-ECs) emerged as an important source of cells for cardiovascular regeneration. This review summarizes protocols for generating hPSC-ECs and provides an overview of the current state of the research in clinical application of hPSC-derived ECs. RECENT FINDINGS: Various systems were developed for differentiating hPSCs into the EC lineage. Stepwise two-dimensional systems are now well established, in which various growth factors, small molecules, and coating materials are used at specific developmental stages...
May 5, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/29730796/the-saga-of-defibrillation-testing-when-less-is-more
#6
REVIEW
Marye J Gleva, Melissa Robinson, Jeanne Poole
PURPOSE OF REVIEW: In the current era of implantable cardioverter-defibrillator procedures, the decision of whether or not to perform defibrillation threshold testing at the time of implantation is now less of a clinical conundrum. In this paper, we summarize this current practice, beginning with the physiology of defibrillation, followed by a review of the salient data, and discussion of specific situations where defibrillation threshold testing remains a clinical consideration. RECENT FINDINGS: Two prospective randomized trials demonstrated no mortality difference and no overall complication rate difference between patients who underwent defibrillation testing at implant compared with patients who underwent no defibrillation testing...
May 5, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/29687241/perspectives-on-current-training-guidelines-for-cardiac-imaging-and-recommendations-for-the-future
#7
REVIEW
James A Arrighi, Sena Kilic, Philip G Haines
PURPOSE OF REVIEW: To summarize current training guidelines for cardiac imaging and provide recommendations for future guidelines. RECENT FINDINGS: The current structure of training in cardiac imaging is largely dictated by modality-specific guidelines. While there has been debate on how to define the advanced cardiac imager for over a decade, a uniform consensus has not emerged. We report the perspectives of three key stakeholders in this debate: a senior faculty member-former fellowship program director, a cardiology fellow, and an academic junior faculty imaging expert...
April 23, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/29680999/current-state-of-left-atrial-appendage-closure
#8
REVIEW
Ricardo Kosturakis, Matthew J Price
PURPOSE OF REVIEW: Atrial fibrillation (AF), the most common sustained arrhythmia, is a major cause of stroke and systemic embolism, and is increasing in prevalence. Device closure of the left atrial appendage (LAA) represents a non-pharmacologic approach to stroke prevention in AF patients. This review presents the rationale for LAA closure (LAAC), describes current transcatheter approaches to LAAC, and summarizes the current evidence for LAAC for stroke prevention, highlighting the main randomized trials and the most recent data available...
April 21, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/29675684/the-role-of-epicardial-fat-in-pericardial-diseases
#9
REVIEW
George Lazaros, Alexios Antonopoulos, Charalambos Antoniades, Dimitris Tousoulis
PURPOSE OF REVIEW: Despite the recent advancements in diagnostic modalities and therapeutic options available, the pathophysiology of pericardial syndromes remains poorly understood. In this review article, we explore the possible links between cardiac adiposity and pericardial syndromes. RECENT FINDINGS: Over the last years, the notion of cardiac adipose tissue has radically changed, and its pivotal role in myocardial diseases has been acknowledged. Recent evidence suggests a cross-talk between epicardial fat and the heart...
April 19, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/29675613/the-role-of-central-blood-pressure-monitoring-in-the-management-of-hypertension
#10
REVIEW
Adrian Ochoa, Gabriel Patarroyo-Aponte, Mahboob Rahman
PURPOSE OF REVIEW: Central blood pressure is a novel predictor of cardiovascular risk that can be measured in the clinical setting using currently available technology. This paper will review current available methods of central blood pressure monitoring as well as its impact in cardiac and renal disease. RECENT FINDINGS: Both aortic and carotid systolic blood pressure are independently associated with cardiovascular mortality and serious cardiac events. Furthermore, studies show that systolic aortic blood pressure has been shown to be superior predictor of cardiovascular as compared to brachial blood pressure...
April 19, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/29667019/what-is-new-in-heart-failure-management-in-2017-update-on-acc-aha-heart-failure-guidelines
#11
REVIEW
Biykem Bozkurt
PURPOSE OF REVIEW: The goal of this paper is to provide a summary of the new recommendations in the most recent 2017 ACC/AHA/HFSA Focused Update of the 2013 ACCF/AHA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Failure Society of America. The intent is to provide the background and the supporting evidence for the recommendations and to provide practical guidance for management strategies in treatment of heart failure patients...
April 17, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/29666940/asd-closure-in-structural-heart-disease
#12
REVIEW
Dominik M Wiktor, John D Carroll
PURPOSE OF REVIEW: While the safety and efficacy of percutaneous ASD closure has been established, new data have recently emerged regarding the negative impact of residual iatrogenic ASD (iASD) following left heart structural interventions. Additionally, new devices with potential advantages have recently been studied. We will review here the potential indications for closure of iASD along with new generation closure devices and potential late complications requiring long-term follow-up...
April 17, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/29666931/genome-editing-and-induced-pluripotent-stem-cell-technologies-for-personalized-study-of-cardiovascular-diseases
#13
REVIEW
Young Wook Chun, Matthew D Durbin, Charles C Hong
PURPOSE OF REVIEW: The goal of this review is to highlight the potential of induced pluripotent stem cell (iPSC)-based modeling as a tool for studying human cardiovascular diseases. We present some of the current cardiovascular disease models utilizing genome editing and patient-derived iPSCs. RECENT FINDINGS: The incorporation of genome-editing and iPSC technologies provides an innovative research platform, providing novel insight into human cardiovascular disease at molecular, cellular, and functional level...
April 17, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/29574623/genetic-risk-prediction-for-primary-and-secondary-prevention-of-atherosclerotic-cardiovascular-disease-an-update
#14
REVIEW
Christopher Labos, George Thanassoulis
PURPOSE OF REVIEW: This review aims to summarize the research on genetic risk scores and their ability to improve risk prediction in both a primary and a secondary prevention population. RECENT FINDINGS: Several groups have examined the role of genetic scores in different patient populations. Recent studies have capitalized on the growing number of identified genetic variants to construct polygenic risk scores that include hundreds and sometimes thousands of SNPs...
March 24, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/29574588/should-primary-prevention-icds-still-be-placed-in-patients-with-non-ischemic-cardiomyopathy-a-review-of-the-evidence
#15
REVIEW
Harsha V Ganga, Abhishek Maan, E Kevin Heist
PURPOSE OF REVIEW: Recent evidence has suggested that implantable defibrillator (ICD) in non-ischemic cardiomyopathy (NICM) may not offer mortality benefit in the presence of guideline-directed medical therapy (GDMT) and cardiac resynchronization therapy (CRT). RECENT FINDINGS: Despite significant benefits of GDMT and CRT, current evidence is derived from ICD trials that rely predominantly on reduced left ventricular ejection fraction alone (LVEF). The majority of patients with sudden cardiac death (SCD) have LVEF > 30% indicating that LVEF by itself is an inadequate predictor of SCD...
March 24, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/29574587/can-nuclear-imaging-techniques-predict-patient-outcome-and-guide-medical-management-in-hereditary-transthyretin-cardiac-amyloidosis
#16
REVIEW
Vincent Algalarrondo, Eve Piekarski, Ludivine Eliahou, Dominique Le Guludec, Michel S Slama, François Rouzet
PURPOSE OF REVIEW: Nuclear imaging recently gained a key role in the diagnosis and prognostic assessment of transthyretin (TTR)-related cardiac amyloidosis. This review aims at summarizing the state-of-the art regarding the implementation of nuclear imaging in the management of hereditary mutated TTR-cardiac amyloidosis (mTTR-CA). RECENT FINDINGS: Although cardiac uptake of bone tracers is acknowledged as a specific marker of TTR amyloid cardiac burden, recent studies validated the implementation of bone scan in the flow chart for non-invasive diagnosis and follow-up of CA in multicenter trials...
March 24, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/29574581/new-algorithm-for-the-prediction-of-cardiovascular-risk-in-symptomatic-adults-with-stable-chest-pain
#17
REVIEW
Muralidhar R Papireddy, Carl J Lavie, Abhizith Deoker, Hadii Mamudu, Timir K Paul
PURPOSE OF REVIEW: To review the landmark studies in predicting obstructive coronary artery disease (CAD) in symptomatic patients with stable chest pain and identify better prediction tools and propose a simplified algorithm to guide the health care providers in identifying low risk patients to defer further testing. RECENT FINDINGS: There are a few risk prediction models described for stable chest pain patients including Diamond-Forrester (DF), Duke Clinical Score (DCS), CAD Consortium Basic, Clinical, and Extended models...
March 24, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/29574550/light-sheet-imaging-to-elucidate-cardiovascular-injury-and-repair
#18
REVIEW
Yichen Ding, Juhyun Lee, Jeffrey J Hsu, Chih-Chiang Chang, Kyung In Baek, Sara Ranjbarvaziri, Reza Ardehali, René R Sevag Packard, Tzung K Hsiai
PURPOSE OF REVIEW: Real-time 3-dimensional (3-D) imaging of cardiovascular injury and regeneration remains challenging. We introduced a multi-scale imaging strategy that uses light-sheet illumination to enable applications of cardiovascular injury and repair in models ranging from zebrafish to rodent hearts. RECENT FINDINGS: Light-sheet imaging enables rapid data acquisition with high spatiotemporal resolution and with minimal photo-bleaching or photo-toxicity. We demonstrated the capacity of this novel light-sheet approach for scanning a region of interest with specific fluorescence contrast, thereby providing axial and temporal resolution at the cellular level without stitching image columns or pivoting illumination beams during one-time imaging...
March 24, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/29574524/addressing-multimorbidity-and-polypharmacy-in-individuals-with-atrial-fibrillation
#19
REVIEW
Fahad Shaikh, Lachlan B Pasch, Phillip J Newton, Beata V Bajorek, Caleb Ferguson
PURPOSE OF REVIEW: The objectives of this review were to (1) discuss how multimorbidity and polypharmacy contributes to the complexity of management among individuals with AF and (2) identify any interventions to manage polypharmacy in relation to AF. RECENT FINDINGS: Based on the four landmark clinical trials of novel anticoagulants, the most common comorbidities with AF are hypertension, heart failure, diabetes, stroke and myocardial infarction. Polypharmacy was also found prevalent in 76...
March 24, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/29574494/motion-correction-and-its-impact-on-absolute-myocardial-blood-flow-measures-with-pet
#20
REVIEW
Marina Piccinelli, John R Votaw, Ernest V Garcia
PURPOSE OF REVIEW: Motion artifacts, due to cardiac and respiratory cycles, myocardial cardiac creep, or gross patient movements, have been extensively investigated in the context of relative myocardial perfusion imaging with SPECT and PET. These movements have been identified as a major source of errors in image quantification and diagnosis. Recently, as dynamic PET quantification for myocardial blood flow assessment has entered clinical practice, similar questions have arisen on the impact of motion on final blood flow values...
March 24, 2018: Current Cardiology Reports
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