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Current Cardiology Reports

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https://www.readbyqxmd.com/read/29992515/preventing-major-amputations-in-patients-with-critical-limb-ischemia
#1
REVIEW
Eric W Rudofker, Shea E Hogan, Ehrin J Armstrong
PURPOSE OF REVIEW: This review summarizes the risks of lower extremity amputation associated with critical limb ischemia (CLI) and discusses current therapies that can prevent amputation in CLI. RECENT FINDINGS: CLI remains an under-recognized condition associated with high rates of major amputation and disparities in care. Optimal medical therapy can reduce the risk of major adverse cardiovascular and limb events, but revascularization combined with close wound care remains the cornerstone of amputation prevention...
July 10, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/29992503/complications-of-cardiac-transplantation
#2
REVIEW
Luciano Potena, Andreas Zuckermann, Francesco Barberini, Arezu Aliabadi-Zuckermann
PURPOSE OF REVIEW: Despite the improvement in medical therapy for heart failure and the advancements in mechanical circulatory support, heart transplantation (HT) still remains the best therapeutic option to improve survival and quality of life in patients with advanced heart failure. Nevertheless, HT recipients are exposed to the risk of several potential complications that may impair their outcomes. In this article, we aim to provide a practical and scholarly framework for clinicians approaching heart transplant medicine, as well as a concise update for the experienced readers on the most relevant post-HT complications...
July 10, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/29992480/cardiovascular-risk-assessment-in-patients-with-hypertriglyceridemia
#3
REVIEW
Matthew C Evans, Tapati Stalam, Michael Miller
PURPOSE OF REVIEW: Assessing the cardiovascular risk associated with hypertriglyceridemia can be challenging due to frequent confounding conditions such as hypertension, diabetes mellitus, and hyperlipidemia. We sought to quantify this risk by examining several meta-analyses as well as subgroup analyses of previously published major randomized controlled trials that focused on the treatment of hyperlipidemia. RECENT FINDINGS: Recent trials measuring the effects of PCSK9 inhibitors such as evolocumab and alirocumab on cardiovascular outcomes have demonstrated a high degree of residual cardiovascular risk even after profound reductions in low-density-lipoprotein cholesterol (LDL-C)...
July 10, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/29992422/an-overview-of-clinical-outcomes-in-transvenous-and-subcutaneous-icd-patients
#4
REVIEW
S W E Baalman, A B E Quast, T F Brouwer, R E Knops
PURPOSE OF REVIEW: Clear guidelines on when to select a subcutaneous ICD (S-ICD) over a transvenous ICD (TV-ICD) are lacking. This review will provide an overview of the most recent clinical data on S-ICD and TV-ICD therapy by pooling comparison studies in order to aid clinical decision making. RECENT FINDINGS: Pooling of observational-matched studies demonstrated an incidence rate ratio (IRR) for device-related complication of 0.90 (95% CI 0.58-1.42) and IRR for lead-related complications of 0...
July 10, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/29987623/coronary-artery-calcium-score-the-mammogram-of-the-heart
#5
REVIEW
Miguel Cainzos-Achirica, Philip A Di Carlo, Catherine E Handy, Renato Quispe, Gerard Roura, Xavier Pinto, Roger S Blumenthal, Josep Comin-Colet, Xavier Corbella, Michael J Blaha
PURPOSE OF REVIEW: To discuss the classic analogy of "coronary artery calcium (CAC) as a mammogram of the heart", by evaluating the conceptual strengths, weaknesses, opportunities, and threats of a potential cardiovascular disease (CVD) screening strategy using CAC in apparently healthy adults. RECENT FINDINGS: CAC is typically used for further CVD risk assessment. CAC is also currently being used as a screening test in specific subgroups of individuals, particularly in some Asian countries...
July 10, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/29971575/cardiovascular-autonomic-dysfunction-in-patients-with-cancer
#6
REVIEW
Ben G T Coumbe, John D Groarke
PURPOSE OF REVIEW: Elucidating the mechanisms that contribute to adverse cardiovascular (CV) outcomes and reduce quality of life among patients with cancer is paramount. Cancer, certain cancer drugs, radiation therapy, cancer-associated lifestyle disturbances, and cancer-independent comorbidities combine to predispose oncology patients to autonomic dysfunction (AD). This review will explore the assessment, etiology, and clinical implications of AD in cancer patients and will speculate on therapeutic and research opportunities...
July 3, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/29946937/long-term-management-of-the-arterial-switch-patient
#7
REVIEW
Jared Kirzner, Altaf Pirmohamed, Jonathan Ginns, Harsimran S Singh
PURPOSE OF REVIEW: This review paper describes the management of patients with dextro-transposition of the great arteries (D-TGA) with a focus on the complications seen and the appropriate care required to identify and prevent adverse events. RECENT FINDINGS: D-TGA is a form of cyanotic congenital heart disease (CHD) representing ~‚ÄČ3% of all CHD and almost 20% of all cyanotic CHD. Since the late 1980s, standard of care is to repair these patients with an arterial switch operation (ASO) as opposed to a Mustard/Senning operation...
June 26, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/29931487/update-on-incorporating-biomarkers-with-imaging-findings-for-the-detection-and-management-of-cardiotoxicity
#8
REVIEW
Neha Quatromoni, Marielle Scherrer-Crosbie
PURPOSE OF REVIEW: Modern cancer therapy comes at a cost of increased risk of cardiotoxicity. The purpose of our paper is to provide an updated review highlighting research incorporating biomarkers and imaging findings for the detection of subclinical cardiac dysfunction and management of cancer treatment-related cardiotoxicity. RECENT FINDINGS: Biomarkers, particularly troponin, NTproBNP, and myeloperoxidase, have been shown to have a predictive role in the development of cancer treatment-related cardiotoxicity...
June 22, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/29926285/cardiovascular-and-renal-outcomes-of-newer-anti-diabetic-medications-in-high-risk-patients
#9
REVIEW
Lima Lawrence, Venu Menon, Sangeeta Kashyap
PURPOSE OF REVIEW: We review the cardiovascular and renal outcomes and safety of newer anti-diabetic medications in high-risk patients. We examine the outcomes of the IRIS, EMPA-REG OUTCOME, CANVAS, LEADER, SAVOR-TIMI 53, and EXAMINE trials demonstrating the cardiovascular and renal benefits of thiazolidinediones, SGLT2 inhibitors, GLP-1 agonists, and DPP-4 inhibitors. RECENT FINDINGS: Diabetes mellitus is a leading risk factor for cardiovascular disease with rising prevalence and disease burden...
June 21, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/29926215/hdl-mimetics-infusion-and-regression-of-atherosclerosis-is-it-still-considered-a-valid-therapeutic-option
#10
REVIEW
I Karalis, J W Jukema
PURPOSE OF REVIEW: This review aims to summarize and discuss the recent findings in the field of using HDL mimetics for the treatment of patients with coronary artery disease. RECENT FINDINGS: Following the largely disappointing results with the cholesteryl ester transfer protein inhibitors, focus moved to HDL functionality rather than absolute HDL cholesterol values. A number of HDL/apoA-I mimicking molecules were developed, aiming to enhance reverse cholesterol transport that has been associated with an atheroprotective effect...
June 21, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/29909444/gender-disparities-in-presentation-management-and-outcomes-of-acute-myocardial-infarction
#11
REVIEW
Matthew Liakos, Puja B Parikh
PURPOSE OF REVIEW: This review provides updates in gender disparities in the symptom profile, risk factors, quality and timeliness of guideline-based medical care, and clinical outcomes, including mortality, bleeding, and vascular complications, in patients with acute myocardial infarction (AMI). RECENT FINDINGS: While AMI continues to be a leading cause of mortality in both men and women, significant gender differences exist in presentation, management, and outcomes...
June 16, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/29904899/use-of-interleukin-1-blockers-in-pericardial-and-cardiovascular-diseases
#12
REVIEW
Giacomo Emmi, Maria Letizia Urban, Massimo Imazio, Marco Gattorno, Silvia Maestroni, Giuseppe Lopalco, Luca Cantarini, Domenico Prisco, Antonio Brucato
PURPOSE OF REVIEW: This review aims to summarize the role of the interleukin-1 (IL-1) blocking agents in cardiovascular diseases, briefly describing the pathogenetic rationale and the most relevant clinical studies. RECENT FINDINGS: IL-1 is a pivotal cytokine of the innate immune system. Anti-IL-1 agents are currently used for the treatment of several autoimmune and autoinflammatory conditions. Recently, the role of IL-1 has also emerged in cardiovascular diseases...
June 14, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/29904823/cardiomyocyte-proliferation-for-therapeutic-regeneration
#13
REVIEW
John P Leach, James F Martin
PURPOSE OF REVIEW: Current pharmacologic treatments for cardiovascular disease do not correct the underlying cellular defect, the loss of cardiomyocytes. With recent advancements in cardiac regenerative approaches, the induction of endogenous mature cardiomyocyte proliferation has emerged as a new possibility. Here, we review progress made toward the regeneration of cardiac tissue in the mammalian heart through the stimulation of mature cardiomyocyte renewal. RECENT FINDINGS: The targeting of several developmental and signaling pathways has been shown to stimulate cell cycle re-entry in mature cardiomyocytes...
June 14, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/29904810/colchicine-in-pericardial-disease-from-the-underlying-biology-and-clinical-benefits-to-the-drug-drug-interactions-in-cardiovascular-medicine
#14
REVIEW
Aldo L Schenone, Venu Menon
PURPOSE OF REVIEW: This is an in-depth review on the mechanism of action, clinical utility, and drug-drug interactions of colchicine in the management of pericardial disease. RECENT FINDINGS: Recent evidence about therapeutic targets on pericarditis has demonstrated that NALP3 inflammasome blockade is the cornerstone in the clinical benefits of colchicine. Such benefits extend from acute and recurrent pericarditis to transient constriction and post-pericardiotomy syndrome...
June 14, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/29904807/determinants-of-achieved-ldl-cholesterol-and-non-hdl-cholesterol-in-the-management-of-dyslipidemias
#15
REVIEW
Chris J Packard
PURPOSE OF REVIEW: The advent of combination therapy to provide LDL lowering beyond that achieved with statins necessitates the development of greater understanding of how drugs work together, what changes occur in key lipoprotein fractions, and what residual risk remains. RECENT FINDINGS: Clinical trials of agents that, when added to statins, generate profound LDL lowering have been successful in reducing further the risk of cardiovascular disease. LDL cholesterol can be now decreased to unprecedented levels, so the focus of attention then shifts to other apolipoprotein B-containing, atherogenic lipoprotein classes such as lipoprotein(a) and remnants of the metabolism of triglyceride-rich particles...
June 14, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/29900479/the-synergistic-use-of-coronary-artery-calcium-imaging-and-noninvasive-myocardial-perfusion-imaging-for-detecting-subclinical-atherosclerosis-and-myocardial-ischemia
#16
REVIEW
Alan Rozanski, Daniel S Berman
PURPOSE OF REVIEW: This review aims to assess the synergistic use of coronary artery calcium (CAC) scanning and stress-rest SPECT myocardial perfusion imaging (MPI) for the workup of patients with suspected coronary artery disease (CAD). RECENT FINDINGS: The CAC score bears a proportional relationship to both the frequency of obstructive CAD and inducible ischemia. Consequently, the test can be used to improve the Bayesian assessment of pre-test CAD likelihood and assist in triaging patients for stress testing...
June 13, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/29860642/recent-progress-in-genome-editing-approaches-for-inherited-cardiovascular-diseases
#17
REVIEW
Balpreet Kaur, Isaac Perea-Gil, Ioannis Karakikes
PURPOSE OF REVIEW: This review describes the recent progress in nuclease-based therapeutic applications for inherited heart diseases in vitro, highlights the development of the most recent genome editing technologies and discusses the associated challenges for clinical translation. RECENT FINDINGS: Inherited cardiovascular disorders are passed from generation to generation. Over the past decade, considerable progress has been made in understanding the genetic basis of inherited heart diseases...
June 2, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/29802591/the-development-and-regeneration-of-coronary-arteries
#18
REVIEW
Lingjuan He, Bin Zhou
PURPOSE OF REVIEW: In this review, we aim to summarize and discuss the cellular origins of the coronary endothelial cells during development and neovascularization in the adult stage after cardiac injury. RECENT FINDINGS: Recent work identified three different developmental origins for coronary endothelial cells: proepicardium, endocardium, and sinus venosus. However, the level of contribution by each source remains debated. During heart injury and regeneration, although multiple cell types such as endothelial progenitor cells, epicardial cells, and endocardial cells were reported to contribute neovascularization, convincing evidence is still lacking...
May 25, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/29802549/cholesterol-lowering-nutraceuticals-affecting-vascular-function-and-cardiovascular-disease-risk
#19
REVIEW
Vanessa Bianconi, Massimo Raffaele Mannarino, Amirhossein Sahebkar, Teresa Cosentino, Matteo Pirro
PURPOSE OF REVIEW: The aim of this review is to provide an update on the effects of the dietary supplementation with cholesterol-lowering nutraceuticals and nutraceutical combinations affecting vascular function and CV risk in clinical interventional studies. RECENT FINDINGS: Current evidence supports the mild-to-moderate cholesterol-lowering efficacy of red yeast rice, berberine, plant sterols, fibers, and some nutraceutical combinations whereas data on the individual cholesterol-lowering action of other nutraceuticals are either less striking or even inconclusive...
May 25, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/29802475/combination-lipid-lowering-therapies-for-the-prevention-of-recurrent-cardiovascular-events
#20
REVIEW
Sara Lee, Christopher P Cannon
PURPOSE OF REVIEW: There has been confusion following the 2013 American College of Cardiology/American Heart Association (ACC/AHA) Lipid guidelines on the role of non-statin medications for cardiovascular prevention. RECENT FINDINGS: Several recent large trials have also now shown that lowering LDL with non-statins reduces cardiovascular events. In ASCVD patients on statins, adding ezetimibe or a PCSK9 inhibitor led to reductions in CV events in the IMPROVE IT, FOURIER, and most recently the ODYSSEY-OUTCOMES trials...
May 25, 2018: Current Cardiology Reports
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