Hong Chen, Mei-Zhen Zhu, Xi-Ting Wang, Min Ai, Shuang-Shuang Li, Ming-Yu Wan, Pei-Yao Wang, Wei-Wei Cai, Bao Hou, Fei Xu, Florian Lang, Li-Ying Qiu, Yue-Tao Zhou
High prevalence and metastasis rates are characteristics of lung cancer. Glycolysis provides energy for the development and metastasis of cancer cells. The 1,25-dihydroxy vitamin D3 (1,25(OH)2 D3 ) has been linked to reducing cancer risk and regulates various physiological functions. We hypothesized that 1,25(OH)2 D3 could be associated with the expression and activity of Na+ /H+ exchanger isoform 1 (NHE1) of Lewis lung cancer cells, thus regulating glycolysis as well as migration by actin reorganization. Followed by online public data analysis, Vitamin D3 receptor, the receptor of 1,25(OH)2 D3 has been proved to be abundant in lung cancers...
November 3, 2023: IUBMB Life