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https://www.readbyqxmd.com/read/30635953/transplacental-delivery-of-genome-editing-components-causes-mutations-in-embryonic-cardiomyocytes-of-mid-gestational-murine-fetuses
#1
Shingo Nakamura, Masayuki Ishihara, Naoko Ando, Satoshi Watanabe, Takayuki Sakurai, Masahiro Sato
Genome editing, as exemplified by CRISPR/Cas9, is now recognized as a powerful tool for the engineering of endogenous target genes. It employs only two components, namely, Cas9 in the form of DNA, mRNA, or protein; and guide RNA (gRNA), which is specific to a target gene. When these components are transferred to cells, they create insertion/deletion mutations (indels) within a target gene. Therefore, when fetuses within the uteri of pregnant murine females are exposed to these reagents, fetal cells incorporating them should show mutations in the target gene...
January 11, 2019: IUBMB Life
https://www.readbyqxmd.com/read/30632663/vitamin-e-regulatory-role-on-gene-and-protein-expression-and-metabolomics-profiles
#2
REVIEW
Hye-Kyeong Kim, Sung Nim Han
Results from microarray analyzes have shown that both vitamin E deficiency and supplementation have a significant impact on the gene expression of various tissues and cells. Genes that were modulated by vitamin E supplementation were different depending on the tissue, which suggested that changes in gene expression are reflective of tissue function and the tissue-specific regulation of vitamin E. In addition, the magnitude of gene expression and types of genes whose expression was altered were differentially affected by the vitamin E forms used for intervention...
January 11, 2019: IUBMB Life
https://www.readbyqxmd.com/read/30629799/nutritional-evaluation-on-lignosus-cameronensis-c-s-tan-a-medicinal-polyporaceae
#3
Shin Yee Fung, Peter Chiew Hing Cheong, Nget Hong Tan, Szu Ting Ng, Chon Seng Tan
Sclerotial powder of a cultivated species of the Tiger Milk Mushroom, Lignosus cameronensis was analysed for its nutritional components and compared against species of the same genus, Lignosus rhinocerus and Lignosus tigris. All three species have been used by indigenous tribes in Peninsular Malaysia as medicinal mushrooms. Content of carbohydrate, fibre, mineral, amino acid, palatable index, fat, ash and moisture were determined. L. cameronensis sclerotial material consists of carbohydrate (79.7%), protein (12...
January 10, 2019: IUBMB Life
https://www.readbyqxmd.com/read/30629798/lncrna-miat-facilitates-osteosarcoma-progression-by-regulating-mir-128-3p-vegfc-axis
#4
Chunyan Zhang, Linsen Xie, Huiling Liang, Yuanbo Cui
The aberrant expression of long non-coding RNAs (lncRNAs) has been involved in the progression of many human tumors including osteosarcoma (OS). However, the biological function and the underlying mechanism of the lncRNA myocardial infarction-associated transcript (MIAT) in OS remain unclear. In the present study, we found that lncRNA MIAT was significantly up-regulated in both OS tissues and cell lines, and high expression of MIAT was positively associated with tumor size and lymph node metastasis of OS patients...
January 10, 2019: IUBMB Life
https://www.readbyqxmd.com/read/30624851/the-great-controlling-nucleotide-coenzymes
#5
REVIEW
Richard L Veech, Michael Todd King, Robert Pawlosky, Yoshihiro Kashiwaya, Patrick C Bradshaw, William Curtis
Nucleotide coenzymes dot the map of metabolic pathways providing energy to drive the reactions of the pathway and play an important role in regulating and controlling energy metabolism through their shared potential energy, which is widely unobserved due to the paradox that the energy in the coenzyme pools cannot be determined from the concentration of the coenzyme couples. The potential energy of the nucleotide couples in the mitochondria or the cytoplasm is expressed in the enzyme reactions in which they take part...
January 9, 2019: IUBMB Life
https://www.readbyqxmd.com/read/30615268/structural-studies-on-m-tuberculosis-argininosuccinate-lyase-and-its-liganded-complex-insights-into-catalytic-mechanism
#6
Anju Paul, Archita Mishra, Avadhesha Surolia, Mamannamana Vijayan
Argininosuccinate lyase catalyses the reversible breakdown of argininosuccinate into arginine and fumarate and is known to form tetramers in its quaternary association. The absence of structures involving competent enzymes bound to substrate/products came in the way of the precise elucidation of the catalytic mechanism of this family of proteins. Crystal structures of the enzyme from Mycobacterium tuberculosis in an unliganded form and its complex with the substrate/products have now been determined at 2.2 and 2...
January 7, 2019: IUBMB Life
https://www.readbyqxmd.com/read/30597731/ring-finger-protein-10-attenuates-vascular-restenosis-by-inhibiting-vascular-smooth-muscle-cell-hyperproliferation-in-vivo-and-vitro
#7
Siyu Li, Guiquan Yu, Fuyu Jing, Hui Chen, Aoyi Liu, Minghao Luo, Wei Huang, Peng Pu, Ming Chen
Vascular smooth muscle cell (VSMC) hyperproliferation is the main pathological process in various cardiovascular diseases, such as vascular restenosis. This process may be repressed by RING finger protein 10 (RNF10) in metabolic syndrome (MetS) rats. The aim of this study is to evaluate the inhibitory effects and molecular mechanisms of RNF10 on VSMC hyperproliferation. Neointimal hyperplasia in MetS and high-glucose-induced VSMC hyperproliferation were measured after infection with adenoviruses encoding RNF10 (Ad-RNF10), short hairpin RNF10 (Ad-shRNF10), or green fluorescent protein (Ad-GFP)...
December 30, 2018: IUBMB Life
https://www.readbyqxmd.com/read/30592131/linc00969-promotes-the-degeneration-of-intervertebral-disk-by-sponging-mir-335-3p-and-regulating-nlrp3-inflammasome-activation
#8
Lei Yu, Yingjie Hao, Chaojun Xu, Guangduo Zhu, Yingchun Cai
Long noncoding RNAs (LncRNAs) may serve as miRNA sponges to regulate the expressions of miRNA target genes. LncRNA LINC00969 has been indicated to be upregulated in intervertebral disk degeneration. However, the regulatory mechanism of LINC00969 in intervertebral disk degeneration progression remains unclear. Differently expressed LINC00969, miR-335-3p, and thioredoxin-interacting protein (TXNIP) were determined in nucleus pulposus (NP) tissues and cells isolated from patients with intervertebral disk degeneration...
December 28, 2018: IUBMB Life
https://www.readbyqxmd.com/read/30592129/role-of-vitamin-e-in-nonalcoholic-fatty-liver-disease
#9
REVIEW
Mayumi Nagashimada, Tsuguhito Ota
Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases worldwide. NAFLD manifests as hepatic lipid accumulation, insulin resistance, and inflammation, and can progress to nonalcoholic steatohepatitis (NASH) and cirrhosis. However, the underlying mechanisms of NAFLD, including those that drive its progression, are unclear. Both liver-resident (Kupffer cells) and recruited macrophages play a crucial role in the development of insulin resistance and NASH. Therefore, NALFD could potentially be ameliorated by modifying the polarization of macrophages/Kupffer cells...
December 27, 2018: IUBMB Life
https://www.readbyqxmd.com/read/30589231/microrna-23a-inhibits-melanoma-cell-proliferation-migration-and-invasion-in-mice-through-a-negative-feedback-regulation-of-sdcbp-and-the-mapk-erk-signaling-pathway
#10
Shelian Lu, Qunyuan Xu
Melanoma is the main cause of death associated with skin cancer. Surgical resection and adjuvant therapy are currently effective treatments, but the recurrence rate is very high. The understanding of microRNA (miR) dynamics after surgical resection of melanoma is essential to accurately explain the changes in the recurrence of melanoma. In this study, we hypothesized that microRNA-23a (miR-23a) affects the cell proliferation, migration, and invasion of melanoma with a mechanism related to SDCBP and the MAPK/ERK signaling pathway...
December 27, 2018: IUBMB Life
https://www.readbyqxmd.com/read/30589200/different-propolis-samples-phenolic-content-and-breast-cancer-cell-lines-variable-cytotoxicity-ranging-from-ineffective-to-potent
#11
Mehmet Fatih Seyhan, Eren Yılmaz, Özlem Timirci-Kahraman, Neslihan Saygılı, Halil İbrahim Kısakesen, Sema Gazioğlu, Ahmet C Gören, Allison Pınar Eronat, A Begüm Ceviz, Tülin Öztürk, Hülya Yılmaz-Aydoğan, Oğuz Öztürk
Researchers have started focusing on investigating the anticarcinogenic effects of natural products with the slightest side effects possible, because current breast cancer treatment approaches are unable to achieve absolute success especially on aggressive subtypes. Propolis is among these products with its antimicrobial, antifungal, anti-inflammatory, and anticancer effects. Therefore, seven different samples were collected from different regions (Argentina, China, and Istanbul-Turkey) and applied on nonaggressive breast cancer cell line (BCCL) MCF-7 and aggressive cell lines SK-BR-3, and MDA-MB-231...
December 27, 2018: IUBMB Life
https://www.readbyqxmd.com/read/30578665/new-paradigm-of-functional-regulation-by-dna-mimic-proteins-recent-updates
#12
REVIEW
Hao-Ching Wang, Chia-Cheng Chou, Kai-Cheng Hsu, Chi-Hua Lee, Andrew H-J Wang
For many, "DNA mimic protein" (DMP) remains an unfamiliar term. The key feature of these proteins is their DNA-like shape and charge distribution, and they affect the activity of DNA-binding proteins by occupying their DNA-binding domains. Functionally, DMPs regulate mechanisms such as gene expression, restriction, and DNA repair as well as the nucleosome package. Although a few DMPs, such as phage uracil DNA glycosylase inhibitor (UGI) and overcome classical restriction (Ocr), were reported about 20 years ago, only a small number of DMPs have been studied to date...
December 22, 2018: IUBMB Life
https://www.readbyqxmd.com/read/30578664/vitamin-e-regulatory-role-of-metabolites
#13
REVIEW
Marc Birringer, Stefan Lorkowski
Vitamin E plays an important role as a lipophilic antioxidant in cellular redox homeostasis. Besides this function, numerous non-antioxidant properties of this vitamin have been discovered in the past. DNA microarray technology revealed a complex regulatory network influenced by the different vitamin E forms (Rimbach et al., Molecules, 15, 1746 (2010); Galli et al., Free Radic. Biol. Med., 102, 16 (2017)); however, little is known about the biological activity of vitamin E metabolites. A new chapter of vitamin E research was been opened when endogenous long-chain tocopherol metabolites were identified and their high biological activity in vitro and in vivo was recognized (Schmölz et al...
December 22, 2018: IUBMB Life
https://www.readbyqxmd.com/read/30576064/ginsenoside-rd-inhibits-the-metastasis-of-colorectal-cancer-via-epidermal-growth-factor-receptor-signaling-axis
#14
Lan Thi Hanh Phi, Ita Novita Sari, Yoseph Toni Wijaya, Kwang Seock Kim, Kichul Park, Art E Cho, Hyog Young Kwon
Ginsenoside Rd is a saponin from ginseng and has been reported to have various biological activities. However, the effect of ginsenoside Rd on the metastasis of colorectal cancer (CRC) remains unknown. Here, we found that ginsenoside Rd decreased the colony-forming ability, migration, invasion, and wound-healing abilities of CRC cells, although it did not affect cell proliferation. In addition, using an inverse-docking assay, we found that ginsenoside Rd bound to epidermal growth factor receptor (EGFR) with a high binding affinity, inducing the downregulation of stemness- and epithelial-mesenchymal transition-related genes; these were partially rescued by either exogenous EGF treatment or ectopic expression of SOX2...
December 21, 2018: IUBMB Life
https://www.readbyqxmd.com/read/30566276/effect-of-naturally-occurring-variations-of-the-f-type-lectin-sequence-motif-on-glycan-binding-studies-on-f-type-lectin-domains-with-typical-and-atypical-sequence-motifs
#15
Aasawari Khairnar, Shailza Sharma, Ritika Bishnoi, Thirumalai Nallan Chakravarthy Ramya
The typical F-type lectin domain (FLD) has an L-fucose-binding motif [HX(26)RXDX(4)R/K] with conserved basic residues that mediate hydrogen bonding with alpha-L-fucose. About one-third of the nonredundant FLD sequences in the publicly available databases are "atypical"; they have motifs with substitutions of these critical residues and/or variations in motif length. We addressed the question if atypical FLDs with substitutions of the critical residues retain lectin activity by performing site-directed mutagenesis and assessing the glycan-binding functions of typical and atypical FLDs...
December 19, 2018: IUBMB Life
https://www.readbyqxmd.com/read/30556640/vitamin-e-mechanism-of-transport-and-regulation-in-the-cns
#16
REVIEW
Paris Lee, Lynn M Ulatowski
Although vitamin E has been recognized as a critical micronutrient to neuronal health for more than half a century, vitamin E transport and regulation in the brain remain a mystery. Currently, the majority of what is known about vitamin E transport has been delineated in the liver. However, clues from the pathogenesis of neurological-related vitamin E deficient diseases point to compromised neuronal integrity and function, underlining the critical need to understand vitamin E regulation in the CNS. Additionally, most of the same molecular players involved in vitamin E transport in the liver are also found in CNS, including sterol SRB1, TTP, and ABCA/ABCG, suggesting similar intracellular pathways between these organ systems...
December 17, 2018: IUBMB Life
https://www.readbyqxmd.com/read/30556637/vitamin-e-regulatory-role-on-signal-transduction
#17
REVIEW
Jean-Marc Zingg
Vitamin E modulates signal transduction pathways by several molecular mechanisms. As a hydrophobic molecule located mainly in membranes it contributes together with other lipids to the physical and structural characteristics such as membrane stability, curvature, fluidity, and the organization into microdomains (lipid rafts). By acting as the main lipid-soluble antioxidant, it protects other lipids such as mono- and poly-unsaturated fatty acids (MUFA and PUFA, respectively) against chemical reactions with reactive oxygen and nitrogen species (ROS and RNS, respectively) and prevents membrane destabilization and cellular dysfunction...
December 17, 2018: IUBMB Life
https://www.readbyqxmd.com/read/30550633/vitamin-e-the-next-100-years
#18
REVIEW
Fatemeh Khadangi, Angelo Azzi
α-Tocopherol is the only tocopherol that has been shown to prevent the human deficiency disease Ataxia with Isolated Vitamin E Deficiency (AVED), and thus it is the only one that, for humans, can be called vitamin E. Vitamin E in addition to preventing AVED has documented immune boosting properties and an activity against nonalcoholic hepatosteatosis and low-grade inflammation. Epidemiological studies indicating that vitamin E could prevent cardiovascular events, neurodegenerative disease, macular degeneration, and cancer were in general not confirmed by clinical intervention studies...
December 14, 2018: IUBMB Life
https://www.readbyqxmd.com/read/30550624/detection-of-malignancy-associated-phosphoproteome-changes-in-human-colorectal-cancer-induced-by-cell-surface-binding-of-growth-inhibitory-galectin-4
#19
Malwina Michalak, Uwe Warnken, Martina Schnölzer, Hans-Joachim Gabius, Jürgen Kopitz
Emerging evidence on efficient tumor growth regulation by endogenous lectins directs interest to determine on a proof-of-principle level the range of information on alterations provided by full-scale analysis using phosphoproteomics. In our pilot study, we tested galectin-4 (gal-4) that is a growth inhibitor for colon cancer cells (CRC), here working with the LS 180 line. In order to cover monitoring of short- and long-term effects stable isotope labeling by amino acids in cell culture-based quantitative phosphoproteomic analyses were conducted on LS 180 cell preparations collected 1 and 72 h after adding gal-4 to the culture medium...
December 14, 2018: IUBMB Life
https://www.readbyqxmd.com/read/30549198/microrna-101-protects-bladder-of-boo-from-hypoxia-induced-fibrosis-by-attenuating-tgf-%C3%AE-smad2-3-signaling
#20
Ning Wang, Liujian Duan, Jie Ding, Qifeng Cao, Subo Qian, Haibo Shen, Jun Qi
Bladder outlet obstruction is a common disease, which always evokes urinary bladder wall remodeling significantly. It has been suggested that bladder outlet obstruction can make the bladder progression from inflammation to fibrosis, and hypoxia may play a vital role. It has been found the expression of microRNA-101 varied in bladder after BOO. But what role microRNA-101 and hypoxia play in bladder is not well known. This study is to investigate the mechanism of microRNA-101 and hypoxia in fibrosis of bladder after BOO...
December 13, 2018: IUBMB Life
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