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Journal of Clinical Hypertension

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https://www.readbyqxmd.com/read/28224730/the-concept-of-crosstalk-directed-embryological-target-mining-and-its-application-to-essential-hypertension-treatment-failures
#1
REVIEW
Alan Alper Sag, Oguzhan Sal, Yagmur Kilic, Emine Meltem Onal, Mehmet Kanbay
This review aims to introduce the novel concept of embryological target mining applied to interorgan crosstalk network genesis, and applies embryological target mining to multidrug-resistant essential hypertension (a prototype, complex, undertreated, multiorgan systemic syndrome) to uncover new treatment targets and critique why existing strategies fail. Briefly, interorgan crosstalk pathways represent the next frontier for target mining in molecular medicine. This is because stereotyped stepwise organogenesis presents a unique opportunity to infer interorgan crosstalk pathways that may be crucial to discovering novel treatment targets...
February 21, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28211216/low-dose-eplerenone-treatment-decreases-aortic-stiffness-in-patients-with-resistant-hypertension
#2
Tatjana Kalizki, Bernhard M W Schmidt, Ulrike Raff, Annemarie Reinold, Thomas K Schwarz, Markus P Schneider, Roland E Schmieder, Andreas Schneider
Vascular damage is aggravated in animal models of hypertension with mineralocorticoid (MR) excess and in hypertensive patients with primary hyperaldosteronism. MR antagonism has shown to provide effective blood pressure (BP)-control in patients with treatment resistant hypertension (TRH), but the concurrent effects on the vasculature have not been examined. In a randomized, double-blinded, placebo-controlled parallel-group study, 51 patients with TRH received either eplerenone 50 mg or placebo for 6 months together with additional antihypertensives titrated to achieve a BP target of <140/90 mm Hg...
February 17, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28194861/association-between-reduced-arterial-stiffness-and-preserved-diastolic-function-of-the-left-ventricle-in-middle-aged-and-elderly-patients
#3
Kyung-Taek Park, Hack-Lyoung Kim, Sohee Oh, Woo-Hyun Lim, Jae-Bin Seo, Woo-Young Chung, Sang-Hyun Kim, Myung-A Kim, Joo-Hee Zo
The aim of this study was to investigate whether arterial stiffness plays a role in retaining normal diastolic function in a middle-aged and elderly Korean population. A total of 267 patients without documented cardiovascular disease, 50 years and older (mean age, 57.3±6.3 years; 69.8% men) were retrospectively analyzed. All patients underwent both transthoracic echocardiography and brachial-ankle pulse wave velocity measurement on the same day. Patients with septal annular peak velocity (e') ≥8 cm/s and left atrial volume index <34 mL/m(2) were considered as having normal diastolic function...
February 13, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28191704/implementing-standardized-performance-indicators-to-improve-hypertension-control-at-both-the-population-and-healthcare-organization-levels
#4
Norm Campbell, Pedro Ordunez, Marc G Jaffe, Marcelo Orias, Donald J DiPette, Pragna Patel, Nadia Khan, Oyere Onuma, Daniel T Lackland
The ability to reliably evaluate the impact of interventions and changes in hypertension prevalence and control is critical if the burden of hypertension-related disease is to be reduced. Previously, a World Hypertension League Expert Committee made recommendations to standardize the reporting of population blood pressure surveys. We have added to those recommendations and also provide modified recommendations from a Pan American Health Organization expert meeting for "performance indicators" to be used to evaluate clinical practices...
February 13, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28177196/end-stage-renal-disease-and-adherence-to-angiotensin-converting-enzyme-inhibitors-and-angiotensin-receptor-blockers-among-patients-with-diabetes
#5
Michal Shani, Shlomo Vinker, Leonid Feldman
Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) have become standards of care for diabetic nephropathy. The authors assessed the association between treatment adherence to ACEIs and ARBs and the development of end-stage renal disease (ESRD). The cohort comprised the 9895 members of the Central District of Clalit Health Services aged 40 to 70 years, diagnosed with diabetes before 2002, who filled at least four ACEI or ARB monthly prescriptions during 2002-2011. Forty-six percent of patients made 10 or more purchases a year...
February 8, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28165190/metabolic-syndrome-and-masked-hypertension-among-african-americans-the-jackson-heart-study
#6
Lisandro D Colantonio, D Edmund Anstey, April P Carson, Gbenga Ogedegbe, Marwah Abdalla, Mario Sims, Daichi Shimbo, Paul Muntner
The metabolic syndrome is associated with higher ambulatory blood pressure. The authors studied the association of metabolic syndrome and masked hypertension (MHT) among African Americans with clinic-measured systolic/diastolic blood pressure (SBP/DBP) <140/90 mm Hg in the Jackson Heart Study. MHT was defined as daytime, nighttime, or 24-hour hypertension on ambulatory blood pressure monitoring. Among 359 participants not taking antihypertensive medication, the metabolic syndrome was associated with MHT (prevalence ratio, 1...
February 6, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28160382/association-between-nondipper-pulse-rate-and-measures-of-cardiac-overload-the-j-hop-study
#7
Yusuke Oba, Tomoyuki Kabutoya, Satoshi Hoshide, Kazuo Eguchi, Kazuomi Kario
This study aimed to investigate the relationship between nondipper pulse rate (PR) and hypertensive target organ damage. Ambulatory blood pressure monitoring was conducted in 940 high-risk Japanese patients enrolled in the Japan Morning Surge Home Blood Pressure Study. Nondipper PR was defined as (awake PR-sleep PR)/awake PR <0.1. The authors measured the patients' brain natriuretic peptide (BNP) and left ventricular mass index (LVMI). The nondipper PR group (n=213) had a significantly higher prevalence of high BNP (≥35 pg/mL, 39...
February 3, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28139099/cardiac-magnetic-resonance-imaging-provides-a-new-insight-in-hypertensive-heart-disease
#8
LETTER
Marijana Tadic, Cesare Cuspidi
No abstract text is available yet for this article.
January 31, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28139052/cardiac-magnetic-resonance-imaging-provides-new-insight-into-hypertensive-heart-disease-a-reply
#9
LETTER
Jonathan C L Rodrigues, Stephen Rohan, Amardeep Ghosh Dastidar, Adam Trickey, Gergely Szantho, Laura E K Ratcliffe, Amy E Burchell, Emma C Hart, Chiara Bucciarelli-Ducci, Mark C K Hamilton, Angus K Nightingale, Julian F R Paton, Nathan E Manghat, David H MacIver
No abstract text is available yet for this article.
January 31, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28127859/sodium-and-potassium-urinary-excretion-levels-of-preschool-children-individual-daily-and-seasonal-differences
#10
Kenichiro Yasutake, Mikako Nagafuchi, Ryoji Izu, Tomomi Kajiyama, Katsumi Imai, Yusuke Murata, Kenji Ohe, Munechika Enjoji, Takuya Tsuchihashi
In this study, the authors measured sodium and potassium concentrations in spot urine samples of preschool children on multiple days, and evaluated individual, daily, and seasonal effects. A total of 104 healthy preschool children aged 4 to 5 years were studied. Urine samples were collected from the first urine of the day after waking for three consecutive days (Monday-Wednesday) four times a year (spring, summer, autumn, winter). The authors estimated the daily urine volume as 500 mL and daily creatinine excretion as 300 mg, and used these to calculate daily sodium and potassium excretion levels...
January 27, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28084026/blood-pressure-is-blood-pressure-is-blood-pressure-or-is-it
#11
Rajiv Agarwal
No abstract text is available yet for this article.
January 13, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28079300/assessing-the-accuracy-of-the-omron-hem-907xl-oscillometric-blood-pressure-measurement-device-in-patients-with-nondialytic-chronic-kidney-disease
#12
Jordana B Cohen, Tiffany C Wong, Bruce S Alpert, Raymond R Townsend
The OMRON HEM-907XL is a commercial oscillometric blood pressure (BP) monitor that was used in the Systolic Blood Pressure Intervention Trial (SPRINT), in which 28% of participants had chronic kidney disease (CKD). This study examined the accuracy of the monitor in nondialytic patients with CKD. Eighty-seven patients met inclusion criteria. The authors used a modified Association for the Advancement of Medical Instrumentation (AAMI) protocol, with one observer recording measurements from the monitor and two blinded physicians obtaining simultaneous aneroid values by auscultation...
January 12, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28075064/efficacy-of-nebivolol-valsartan-single-pill-combination-in-obese-and-nonobese-patients-with-hypertension
#13
Christian W Mende, Thomas D Giles, David B Bharucha, William G Ferguson, Madhuja Mallick, Mehul D Patel
Antihypertensive efficacy of single-pill combinations (SPCs) consisting of a β1 -selective adrenergic blocker with vasodilatory properties via β3 -agonism (nebivolol) and an angiotensin II receptor blocker (valsartan) was demonstrated in an 8-week phase 3 trial (NCT01508026). In this post hoc analysis, seated blood pressure, heart rate, 24-hour ambulatory blood pressure monitoring, plasma aldosterone, estimated glomerular filtration rate, and safety measures were assessed in obese (body mass index >32 kg/m(2) ; n=1823) and nonobese (body mass index <27 kg/m(2) ; n=847) adults with hypertension (stage I or II) treated with nebivolol-valsartan SPCs, nebivolol or valsartan monotherapy, or placebo...
January 11, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28058813/outcomes-of-a-multi-community-hypertension-implementation-study-the-american-heart-association-s-check-change-control-program
#14
Monique L Anderson, Rachel Peragallo Urrutia, Emily C O'Brien, Nancy M Allen LaPointe, Alexander J Christian, Lisa A Kaltenbach, Laura E Webb, Angel M Alexander, Paramita Saha Chaudhuri, Juliana Crawford, Patrick Wayte, Eric D Peterson
: Single-site, intensive, community-based blood pressure (BP) intervention programs have led to BP improvements. The authors examined the American Heart Association's Check. Change. CONTROL: (CCC) program (4069 patients/18 cities) to determine whether BP interventions can effectively be scaled to multiple communities, using a simplified template and local customization. Effectiveness was evaluated at each site via site percent enrollment goals, participant engagement, and BP change from first to last measurement...
January 6, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28058765/the-impact-of-an-individualized-risk-adjusted-approach-on-hypertension-treatment-in-primary-care
#15
Stefan Zechmann, Oliver Senn, Fabio Valeri, Stefan Neuner-Jehle, Thomas Rosemann, Sima Djalali
Previous studies suggest that up to 60% of all patients with hypertension receive inappropriate treatment. Current 2013 European Society of Hypertension/European Society of Cardiology (ESH/ESC) guidelines recommend taking cardiovascular risk factors into account when assessing treatment for patients with hypertension. The authors hypothesize that this approach will reduce the proportion of patients receiving inappropriate treatment. In this cross-sectional study using electronic medical records of Swiss primary care patients, the authors estimate the proportion of patients receiving inappropriate treatment using two approaches: (1) based on a blood pressure threshold of 140/90 mm Hg; and (2) based on cardiovascular risk factors...
January 6, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28042916/glucose-homeostasis-abnormalities-among-cameroon-patients-with-newly-diagnosed-hypertension
#16
Félicité Kamdem, Daniel Lemogoum, Marie-Solange Doualla, Fernando Kemta Lepka, Elvis Temfack, Yvette Ngo Nouga, Caroline Kenmegne, Henry Luma, Michel P Hermans
The authors assessed the frequency of glucose homeostasis abnormalities among 839 Cameroonians with newly diagnosed hypertension (mean age: 50.8±11 years; 49.9% female) in a cross-sectional survey conducted at the Douala General Hospital, Douala, Cameroon. In all participants, blood pressure, fasting plasma glucose (FPG), and lipids were recorded. Impaired fasting glycemia was described as an FPG level between 100 and 125 mg/dL and provisional diabetes as an FPG level ≥126 mg/dL. The FPG was 101±30 mg/dL...
January 2, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28042913/new-evidence-for-the-diastolic-j-curve-effect-challenges-the%C3%A2-safety-of-intensive-blood-pressure-control
#17
Steven G Chrysant
No abstract text is available yet for this article.
January 2, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28026098/risk-factors-for-preeclampsia-in-infertile-chinese-women-with-polycystic-ovary-syndrome-a-prospective-cohort-study
#18
Hexia Xia, Ruixiu Zhang, Xiaoli Sun, Lu Wang, Wei Zhang
To explore preconception risk factors for preeclampsia (PE) in women with polycystic ovary syndrome (PCOS), a prospective cohort study was conducted in 92 infertile Chinese women with PCOS who had a singleton pregnancy by ovulation induction and were followed up for 6 weeks after delivery. The patients underwent assessment of physical, endocrine, and metabolic features before ovulation induction. Fifteen (16.3%) patients were diagnosed with PE. Logistic regression analysis showed that preconception sex hormone-binding globulin (SHBG), insulin level at 120 minutes, and body mass index were three independent risk factors for PE (odds ratio [OR], 0...
December 27, 2016: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28026096/interarm-blood-pressure-differences-predict-target-organ-damage-in-type-2-diabetes
#19
Francesco Spannella, Federico Giulietti, Massimiliano Fedecostante, Maddalena Ricci, Paolo Balietti, Guido Cocci, Laura Landi, Anna Rita Bonfigli, Massimo Boemi, Emma Espinosa, Riccardo Sarzani
Patients with type 2 diabetes mellitus are at high risk for atherosclerotic disease, and proper blood pressure measurement is mandatory. The authors examined the prevalence of an interarm difference (IAD) in blood pressure and its association with cardiovascular risk factors and organ damage (nephropathy, retinopathy, left ventricular hypertrophy, and vascular damage) in a large diabetic population. A total of 800 consecutive patients with type 2 diabetes mellitus were evaluated with an automated simultaneous bilateral device (men: 422 [52...
December 27, 2016: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28019714/a-prospective-study-of-the-association-between-total-sleep-duration-and-incident-hypertension
#20
Dhananjay Yadav, Dae Sung Hyun, Song Vogue Ahn, Sang-Baek Koh, Jang Young Kim
The aim of this prospective study was to evaluate total sleep duration as a potential risk factor for the development of hypertension after a mean of 2.6 years of follow-up. The study participants comprised 1715 Korean adults aged 40 to 70 years. The participants were without hypertension at baseline (2005-2008) and during follow-up (2008-2011) to determine the incident cases of hypertension. Based on a self-reported questionnaire, the individuals were stratified according to total sleep duration (<6 hours, 6-7...
December 26, 2016: Journal of Clinical Hypertension
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