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Journal of Clinical Hypertension

Alejandro Diaz, Yanina Zócalo, Daniel Bia, Sandra Wray, Edmundo Cabrera Fischer
There is little information regarding age-related reference intervals (RIs) of carotid-femoral pulse wave velocity (cfPWV) for large healthy populations in South America. The aims of this study were to determine cfPWV RIs and percentiles in a cohort of healthy children, adolescents, and adults and to generate year-to-year percentile curves and body-height percentile curves for children and adolescents. cfPWV was measured in 1722 healthy participants with no cardiovascular risk factors (9-87 years, 60% men)...
March 13, 2018: Journal of Clinical Hypertension
Omar Al Dhaybi, George L Bakris
No abstract text is available yet for this article.
March 13, 2018: Journal of Clinical Hypertension
Yan Gong, Steven M Smith, Eileen M Handberg, Carl J Pepine, Rhonda M Cooper-DeHoff
The objective of this analysis is to determine the effect of intensive (<120 mm Hg) versus standard (<140 mm Hg) systolic blood pressure (SBP) targets on cardiovascular (CV) outcomes among SPRINT participants with low-normal or high-normal fasting glucose (FG). We categorized the 5425 SPRINT participants with FG <100 mg/dL into 2 groups: <85 mg/dL (low-normal) and 85 to <100 mg/dL (high-normal). Among participants with low-normal glucose, there was no significant difference in the primary outcome (PO) between the 2 treatment arms (adjusted hazard ratio, HR: 1...
March 13, 2018: Journal of Clinical Hypertension
Philip Gerretsen, Julia Kim, Parita Shah, Lena Quilty, Thushanthi Balakumar, Fernando Caravaggio, Eric Plitman, Jun Ku Chung, Yusuke Iwata, Bruce G Pollock, Satya Dash, Sanjeev Sockalingam, Ariel Graff-Guerrero
Impaired illness awareness or not accepting that one has hypertension (HTN) may be an important predictor of treatment adherence and optimal blood pressure control. The purpose of this study was to perform a systematic review of available instruments to evaluate HTN awareness, and subsequently present a novel scale that measures the core domains of subjective illness awareness in HTN. Based on the absence of any validated HTN specific measure identified through our review, the Blood Pressure Awareness and Insight Scale (BASIS) was developed (www...
March 10, 2018: Journal of Clinical Hypertension
Magnus O Wijkman
No abstract text is available yet for this article.
March 9, 2018: Journal of Clinical Hypertension
Jamario Skeete, Donald J DiPette
No abstract text is available yet for this article.
March 9, 2018: Journal of Clinical Hypertension
Yandiswa Y Yako, Eric V Balti, Tandi E Matsha, Anastase Dzudie, Deirdre Kruger, Eugene Sobngwi, Charles Agyemang, Andre P Kengne
In a systematic review, the authors explored genetic association studies of essential hypertension in African populations. Studies reporting on the association of polymorphism(s) with hypertension in African populations were included. Appropriate studies were pooled using random effects model meta-analysis, under six potential inheritance models. In all, 46 polymorphisms in 33 genes were investigated for their association with hypertension or blood pressure levels. Meta-analysis was possible for three single nucleotide polymorphisms: rs4340, rs699, and rs5186...
March 9, 2018: Journal of Clinical Hypertension
Yoav Eizenberg, Ehud Grossman, David Tanne, Silvia Koton
The impact of beta-blockers (BB) treatment on stroke outcome is unclear. We used data from a prospective national stroke registry to assess the associations between use of BB and poor outcome 3 months after stroke. Using the National Acute Stroke Israeli (NASIS) registry, we identified 1126 patients with ischemic stroke and intracerebral hemorrhage with pre-stroke hypertension treatment, who were followed for 3-months. Functional outcome and mortality at 3-month were compared by use of BB, adjusting for demographics and clinical factors...
March 9, 2018: Journal of Clinical Hypertension
Jonathan C L Rodrigues, Antonio Matteo Amadu, Amardeep Ghosh Dastidar, Iwan Harries, Amy E Burchell, Laura E K Ratcliffe, Emma C Hart, Mark C K Hamilton, Julian F R Paton, Angus K Nightingale, Nathan E Manghat
We investigate the impact of dipper status on cardiac structure with cardiovascular magnetic resonance (CMR). Ambulatory blood pressure monitoring and 1.5T CMR were performed in 99 tertiary hypertension clinic patients. Subgroup analysis by extreme dipper (n = 9), dipper (n = 39), non-dipper (n = 35) and reverse dipper (n = 16) status was performed, matched in age, gender and BMI. Left ventricular (LV) mass was significantly higher for extreme dippers than dippers after correction for covariates (100 ± 6 g/m2 vs 79 ± 3 g/m2 , P = ...
March 8, 2018: Journal of Clinical Hypertension
George L Bakris, Lin Zhao, Stuart Kupfer, Attila Juhasz, Michie Hisada, Eric Lloyd, Suzanne Oparil
An open-label, long-term study evaluated safety and tolerability of azilsartan medoxomil/chlorthalidone (AZL-M/CLD) vs olmesartan/hydrochlorothiazide (OLM/HCTZ) in hypertensive participants with stage 3 chronic kidney disease. Initial therapy was AZL-M/CLD 20/12.5 mg (n = 77) or OLM/HCTZ 20/12.5 mg (n = 76), but could be up-titrated (AZL-M/CLD to 40/25 mg; OLM/HCTZ to 40/25 mg [US] or 20/25 mg [Europe]) with other agents added during weeks 4-52. Primary endpoint was proportion of participants with ≥ 1 adverse event (AE) through week 52...
March 4, 2018: Journal of Clinical Hypertension
Walter M van der Merwe
No abstract text is available yet for this article.
March 4, 2018: Journal of Clinical Hypertension
Ignatios Ikonomidis, Astrinos Voumvourakis, George Makavos, Helen Triantafyllidi, George Pavlidis, Konstantinos Katogiannis, Dimitris Benas, Dimitris Vlastos, Paraskevi Trivilou, Maria Varoudi, John Parissis, Efstathios Iliodromitis, John Lekakis
We investigated the association of endothelial glycocalyx damage with arterial stiffness, impairment of coronary microcirculatory function, and LV myocardial deformation in 320 untreated hypertensives and 160 controls. We measured perfused boundary region (PBR) of the sublingual microvessels, a marker inversely related with glycocalyx thickness, coronary flow reserve (CFR), and Global Longitudinal strain (GLS) by echocardiography, pulse wave velocity (PWV), and central systolic blood pressure (cSBP). Hypertensives had higher PBR, PWV cSBP, and lower CFR and GLS than controls (P < ...
March 2, 2018: Journal of Clinical Hypertension
Lulu Chen, Binyan Wang, Jiancheng Wang, Qianyun Ban, Hongxu Wu, Yun Song, Jingping Zhang, Jingjing Cao, Ziyi Zhou, Lishun Liu, Tianyu Cao, Lan Gao, Huiyuan Guo, Tao Zhang, Genfu Tang, Xiao Huang, Yan Zhang, Jianping Li, Yong Huo, Xiaoshu Cheng, Tonghua Zang, Xiping Xu, Hao Zhang, Xianhui Qin
Both increased arterial stiffness and higher total homocysteine (tHcy) are associated with an elevated risk for cardiovascular disease. However, the relationship between tHcy and arterial stiffness is still inconclusive. The authors aimed to test the relationship of tHcy with carotid-femoral pulse wave velocity (cfPWV) and examine the possible effect modifiers in adults. A study was conducted from July to September 2016 in Jiangsu Province, China. A total of 16 644 participants were enrolled in the final analysis...
February 26, 2018: Journal of Clinical Hypertension
Takeshi Fujiwara, Satoshi Hoshide, Hiroshi Kanegae, Kazuo Eguchi, Kazuomi Kario
We investigated the association between working memory (WM) impairment and blood pressure variability (BPV) in very elderly patients. Japanese outpatients ≥80 years who engaged in normal activities of daily living were the study cohort. WM function was evaluated by a simple visual WM test consisting of 3 figures. We considered the number of figures recalled by the patient his/her test score. We defined the patients with a score of 0 or 1 as those with WM impairment and those with scores of 2 or 3 as those without...
February 21, 2018: Journal of Clinical Hypertension
Simona Lattanzi, Fabrizio Vernieri, Mauro Silvestrini
No abstract text is available yet for this article.
February 21, 2018: Journal of Clinical Hypertension
Vivian S S Gonçalves, Taís F Galvão, Marcus T Silva, Maria C Kuschnir, Eliane S Dutra, Kênia M B Carvalho
Given the high prevalence of hypertension in adolescents, it is important to investigate alternatives for estimating the magnitude of the disease. Our objective was to investigate the accuracy of self-reported hypertension. The study assessed participants of the Study of Cardiovascular Risk in Adolescents (ERICA). The following were calculated: sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV). The associations between inaccurate self-reporting and socioeconomic factors were investigated...
February 20, 2018: Journal of Clinical Hypertension
Luis M Ruilope, Jose R Banegas
No abstract text is available yet for this article.
February 19, 2018: Journal of Clinical Hypertension
Andrew Sherwood, Christi S Ulmer, Jean C Beckham
No abstract text is available yet for this article.
February 19, 2018: Journal of Clinical Hypertension
Shikai Yu, Chen Chi, Athanase D Protogerou, Michel E Safar, Jacques Blacher, Antonis A Argyris, Efthimia G Nasothimiou, Petros P Sfikakis, Theodore G Papaioannou, Henry Xu, Yi Zhang, Yawei Xu
We aim to compare 24-hour aortic blood pressure variability (BPV) with brachial BPV in relation to carotid damage as estimated by carotid intima-media thickness (CIMT) and cross-sectional area (CCSA). Four hundred and forty five individuals received brachial and aortic 24-hour ambulatory BP monitoring with a validated device (Mobil-O-Graph). Systolic BPV was estimated by average real variability (ARV) and time-weighted standard deviation (wSD). In multiple logistic regression analysis, CIMT > 900 μm was significantly and independently associated with aortic ARV (OR = 1...
February 19, 2018: Journal of Clinical Hypertension
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