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Breast Cancer: the Journal of the Japanese Breast Cancer Society

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https://www.readbyqxmd.com/read/28070832/objection-to-postoperative-radiation-therapy-in-breast-cancer-with-one-to-three-lymph-nodes-involvements
#1
Takashi Ishikawa, Hiroshi Kaise, Kimito Yamada, Mari Hosonaga, Takashi Chishima, Kazutaka Narui, Akimitsu Yamada, Sadatoshi Sugae, Yasushi Ichikawa, Mitsuyoshi Ota, Miyako Nozaki, Ryuji Mikami, Koichi Tokuuye
My arguments regarding postmastectomy radiotherapy (PMRT) for this case are based on the following 4 reasons: (1) high rate of local recurrence in the no PMRT group in the Early Breast Cancer Trialists' Collaborative Group meta-analysis on which the present guideline is based, (2) stage migration by sentinel node biopsy, (3) possible adverse events of radiotherapy, and (4) problems on extrapolation of data from western countries.
January 9, 2017: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/28070831/the-prolyl-oligopeptidase-inhibitor-suam-14746-attenuates-the-proliferation-of-human-breast-cancer-cell-lines-in-vitro
#2
Satoshi Tanaka, Kanayo Suzuki, Minoru Sakaguchi
BACKGROUND: Prolyl oligopeptidase (POP, EC 3.4.1.26) is a serine peptidase that hydrolyzes post-proline peptide bonds in peptides that are <30 amino acids in length. We previously reported that POP inhibition suppressed the growth of NB-1 human neuroblastomas cells and KATO III human gastric cancer cells. POP activity is commonly elevated in many cancers, which includes breast cancer. However, the effect of POP inhibition as a candidate breast cancer therapy is unknown. METHODS: The effects of POP inhibition and knockdown on the proliferation of cultured human estrogen receptor-positive (ER+) MCF7 and T47D, and ER-negative (ER-) MDA-MB-231 breast cancer cell lines and the MCF12A non-tumorigenic epithelial cell line were tested by analyzing their influence on cell proliferation (WST-1 assay), cell viability (trypan blue exclusion assay), and cell cycle arrest (cell cycle analysis, cell cycle regulator proteins expression)...
January 9, 2017: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/28058615/complete-remission-in-metastatic-breast-cancer-expecting-the-unexpected-results-of-a-cross-sectional-study
#3
Giulia Galli, Anna Tessari, Luca Porcu, Giacomo Bregni, Biagio Paolini, Maria Luisa Carcangiu, Massimiliano Gennaro, Maria Carmen De Santis, Laura Lozza, Filippo de Braud, Serena Di Cosimo
BACKGROUND: Complete response (CR) in metastatic breast cancer (MBC) is rare. This study aims at analyzing the characteristics and outcome of MBC patients achieving CR. METHODS: We performed a cross-sectional analysis of clinical data from a consecutive series of MBC patients admitted at the Division of Medical Oncology of Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy, achieving CR following treatment for systemic disease and with at least 2 years of follow-up...
January 5, 2017: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/28058614/simultaneous-atm-brca1-rad51-expression-variations-associated-with-prognostic-factors-in-iranian-sporadic-breast-cancer-patients
#4
Zeinab Hallajian, Frouzandeh Mahjoubi, Nahid Nafissi
BACKGROUND: DNA double-strand breaks (DSBs) as a serious lesion are repaired by non-homologous end-joining and homologous recombination pathways. ATM, BRCA1, RAD51 genes are involved in HR pathways. While some studies have revealed individual expression changes of these genes in different types of cancer, there are limited studies attempting to evaluate correlation of expression variations of these genes in breast cancer pathogenesis. This study aimed to determine RAD51, ATM and BRCA1 gene expression level and its association with clinicopathological factors in fresh breast cancer tissues...
January 5, 2017: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/28050738/preoperative-neoadjuvant-chemotherapy-using-nanoparticle-albumin-bound-paclitaxel-followed-by-epirubicin-and-cyclophosphamide-for-operable-breast-cancer-a-multicenter-phase-ii-trial
#5
Manabu Futamura, Yasuko Nagao, Kazuhiro Ishihara, Makoto Takeuchi, Takumi Nakada, Yoshihiro Kawaguchi, Masayoshi Asano, Iwao Kumazawa, Takashi Shiroko, Kasumi Morimitsu, Ryutaro Mori, Masahito Nawa, Toshio Shimokawa, Kazuhiro Yoshida
BACKGROUND: Recently, the use of taxane-based regimens before anthracycline-based regimens has been shown to achieve high pathological complete response (pCR) rates in patients with breast cancer. Nanoparticle albumin-bound paclitaxel (nab-PTX) has been reported as highly effective and less toxic compared with Cremophor-based Taxol. This phase II clinical trial evaluated the safety and efficacy of preoperative neoadjuvant chemotherapy (NAC) with nab-PTX followed by an epirubicin plus cyclophosphamide (EC)-based regimen for operable breast cancer...
January 3, 2017: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/28008557/the-effects-of-complex-exercise-on-shoulder-range-of-motion-and-pain-for-women-with-breast-cancer-related-lymphedema-a-single-blind-randomized-controlled-trial
#6
Jin-Hyuck Park
BACKGROUND: This study was to investigate the effects of complex exercise on shoulder range of motion and pain for women with breast cancer-related lymphedema. METHODS: 69 women participated in this study and then they were randomly allocated to complex exercise group (n = 35) or the conventional decongestive therapy group (n = 34). All subjects received 8 sessions for 4 weeks. To identify the effects on shoulder range of motion and pain, goniometer and visual analog scale were used, respectively...
December 23, 2016: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/27943163/atypical-femoral-fracture-after-receiving-antiresorptive-drugs-in-breast-cancer-patients-with-bone-metastasis
#7
Seiya Ota, Ryo Inoue, Takashi Shiozaki, Yuji Yamamoto, Naoki Hashimoto, On Takeda, Kei Yoshikawa, Junji Ito, Yasuyuki Ishibashi
BACKGROUND: Atypical femoral fracture (AFF) occurs with minor trauma in patients receiving antiresorptive drugs such as bisphosphonate and denosumab. We hypothesized that patients with bone metastasis who receive higher doses of antiresorptive drugs tend to experience AFF more frequently. This study aimed to investigate the prevalence rate of AFF in patients receiving antiresorptive drugs for bone metastasis of breast cancer. METHODS: Based on the database from our hospital, patients with breast cancer between March and September 2014 were investigated...
December 10, 2016: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/27896661/erratum-to-breast-reconstruction-using-free-medial-circumflex-femoral-artery-perforator-flaps-intraoperative-anatomic-study-and-clinical-results
#8
Mai Shibuya, Toshihiko Satake, Reiko Nakasone, Marina Ogawa, Mayu Muto, Kazutaka Narui, Kazunori Yasumura, Takashi Ishikawa, Jiro Maegawa
No abstract text is available yet for this article.
November 28, 2016: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/27882505/antitumor-immunity-and-advances-in-cancer-immunotherapy
#9
EDITORIAL
Tomoharu Sugie, Masakazu Toi
No abstract text is available yet for this article.
November 23, 2016: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/27878697/nf%C3%AE%C2%BAbp65-transcription-factor-modulates-resistance-to-doxorubicin-through-abc-transporters-in-breast-cancer
#10
Kobra Velaei, Nasser Samadi, Sina Soltani, Balal Barazvan, Jafar Soleimani Rad
BACKGROUND: Shedding light on chemoresistance biology of breast cancer could contribute to enhance the clinical outcome. Intrinsic or acquired resistance to chemotherapy is a major problem in breast cancer treatment. METHODS AND MATERIALS: The NFκB pathway by siRNAP65 and JSH-23 as a translocational inhibitor of NFκBP65 in the doxorubicin-resistant MCF-7 (MCF-7/Dox) and MCF-7 cells was blocked. Then, the ABC transporter expression and function were assessed by real-time qRT-PCR and flow cytometry, respectively...
November 23, 2016: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/27878446/accuracy-assessment-methods-of-tissue-marker-clip-placement-after-11-gauge-vacuum-assisted-stereotactic-breast-biopsy-comparison-of-measurements-using-direct-and-conventional-methods
#11
Hidetoshi Yatake, Yuka Sawai, Toshio Nishi, Yoshiaki Nakano, Ayaka Nishimae, Toshizo Katsuda, Koichi Yabunaka, Yoshihiro Takeda, Hideo Inaji
BACKGROUND: The objective of the study was to compare direct measurement with a conventional method for evaluation of clip placement in stereotactic vacuum-assisted breast biopsy (ST-VAB) and to evaluate the accuracy of clip placement using the direct method. METHODS: Accuracy of clip placement was assessed by measuring the distance from a residual calcification of a targeted calcification clustered to a clip on a mammogram after ST-VAB. Distances in the craniocaudal (CC) and mediolateral oblique (MLO) views were measured in 28 subjects with mammograms recorded twice or more after ST-VAB...
November 22, 2016: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/27873170/overcalling-low-risk-findings-grouped-amorphous-calcifications-found-at-screening-mammography-associated-with-minimal-cancer-risk
#12
Madoka Iwase, Hiroko Tsunoda, Kanako Nakayama, Emiko Morishita, Naoki Hayashi, Koyu Suzuki, Hideko Yamauchi
BACKGROUND: Because of the increasing availability of screening mammography and spread of information about its benefits, the incidence of early breast cancer has been increasing in Japan. However, screening mammography can result in overdiagnoses or false positives, causing in some subjects undergoing unnecessary invasive procedures. The current mammography guidelines recommend further investigation of subjects with grouped amorphous calcifications; this recommendation may have resulted in overdiagnoses or false positives...
November 21, 2016: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/27848085/long-non-coding-rna-tug1-promotes-cell-proliferation-and-metastasis-in-human-breast-cancer
#13
Teng Li, Yun Liu, Haifeng Xiao, Guanghui Xu
BACKGROUND: Long non-coding RNAs (LncRNAs) utilize a wide variety of mechanisms to regulate RNAs or proteins on the transcriptional or post-transcriptional levels. Accumulating studies have identified numerous LncRNAs to exert critical effects on different physiological processes, genetic disorders, and human diseases. MATERIALS AND METHODS: Both clinical tissues from breast cancer patients and cultured cells were used for the qRT-PCR analysis. Specific siRNAs were included to assess the roles of TUG1 with cell viability assay, transwell assay, and cell apoptosis assay, respectively...
November 15, 2016: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/27838870/evaluation-of-the-sonographic-visibility-and-sonographic-appearance-of-the-breast-biopsy-marker-ultraclip-%C3%A2-placed-in-phantoms-and-patients
#14
Naomi Sakamoto, Yukari Ogawa, Yuko Tsunoda, Eisuke Fukuma
PURPOSE: To evaluate the usefulness of the UltraClip(®) dual trigger breast tissue marker (UltraClip) for sonographic localization, we investigate the sonographic visibility and sonographic appearance of the UltraClip placed in phantoms and patients. MATERIALS AND METHODS: Ten UltraClips were placed in the target lesions in the phantoms. After the ultrasound examination of the UltraClip, the ultrasound images were compared to the real appearance of the UltraClip obtained by cutting the phantoms...
November 12, 2016: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/27837442/non-calcified-ductal-carcinoma-in-situ-of-the-breast-comparison-of-diagnostic-accuracy-of-digital-breast-tomosynthesis-digital-mammography-and-ultrasonography
#15
Xiaohui Su, Qing Lin, Chunxiao Cui, Wenjian Xu, Zhimin Wei, Jie Fei, Lili Li
BACKGROUND: To retrospectively compare the diagnostic accuracy of digital breast tomosynthesis (DBT), digital mammography (DM), and ultrasonography (US) in non-calcified ductal carcinoma in situ (DCIS, include DCIS with micro-invasion). PATIENTS AND METHODS: Ninety-eight patients with non-calcified DCIS (include DCIS with micro-invasion) were enrolled in our study. Breast carcinoma in situ was confirmed by surgical pathologic evaluation. Our Institutional Review Board granted approval and the participating women provided written informed consent...
November 11, 2016: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/27837441/tp53-codon-72-polymorphism-and-breast-cancer-risk-in-bangladeshi-population
#16
Amir Hossain, Gazi Md Monjur Murshid, Md Nazmul Hasan Zilani, Fahrima Islam, Razia Sultana, Tamanna Sultana, Md Golam Hossain, Md Mustafizur Rahman
BACKGROUND: Breast cancer, a hereditary or heterogeneous sporadic disease, is the most common cancer in women worldwide. The tumor suppressor TP53 gene has been found to be the most commonly mutated genes in many types of human cancers, including breast cancer. This study aimed to investigate the association of codon 72 polymorphism of TP53 gene with breast cancer risk in Bangladeshi females. METHODS: The study included 125 cases and 125 healthy controls. Genotyping and polymorphism were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis...
November 11, 2016: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/27812996/effect-of-the-childhood-trauma-on-the-adjustment-to-cancer-in-the-patients-with-breast-cancer
#17
Hulya Guveli, Murat Emin Guveli, Fatma Sen, Serap Oflaz, Necla Gurdal, Makbule Tambas, Seden Kucucuk, Adnan Aydıner, Mine Ozkan
BACKGROUND: Early identification of patients coping poorly is important for compliance with treatment and control of distress. This study aims to investigate the effect of the childhood trauma experience on the type of reaction and adjustment that the person exhibits to the cancer among the patients with breast cancer. METHODS: This cross-sectional study enrolled 310 patients with breast cancer. The effect of the childhood trauma and the psychological condition on the adjustment to cancer was investigated by assessing the adjustment to cancer, the experiences of childhood trauma and psychological status of the subjects using mental adjustment to cancer scale (MAC), childhood trauma questionnaire (CTQ28), Beck Depression Inventory (BDI) and Beck anxiety inventory (BAI)...
November 3, 2016: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/27796923/recent-development-of-targeted-approaches-for-the-treatment-of-breast-cancer
#18
V L Maruthanila, R Elancheran, A B Kunnumakkara, S Kabilan, Jibon Kotoky
Breast cancer is the most prominent cause of cancer death in women worldwide. The highlights of this review are to provide an overview of the targeted therapeutic agents, challenges with metastatic breast cancer (MBCa), mechanisms of action through Hedgehog/Gli 1 signaling pathway and future prospective. Over a decade of success, several drugs have been approved and are in the advanced stages of clinical trials that target the receptors such as estrogen receptor, growth factor receptor, receptor activator of nuclear factor kappa-B, etc...
October 31, 2016: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/27259342/the-need-for-supplemental-breast-cancer-screening-modalities-a-perspective-of-population-based-breast-cancer-screening-programs-in-japan
#19
Takayoshi Uematsu
PURPOSE: This article discusses possible supplemental breast cancer screening modalities for younger women with dense breasts from a perspective of population-based breast cancer screening program in Japan. CONCLUSION: Supplemental breast cancer screening modalities have been proposed to increase the sensitivity and detection rates of early stage breast cancer in women with dense breasts; however, there are no global guidelines that recommend the use of supplemental breast cancer screening modalities in such women...
January 2017: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/27138387/immune-infiltrates-in-the-breast-cancer-microenvironment-detection-characterization-and-clinical-implication
#20
Samantha Burugu, Karama Asleh-Aburaya, Torsten O Nielsen
Although unlike melanoma, breast cancer is not generally viewed as a highly immunogenic cancer, recent studies have described a rich tumor immune microenvironment in a subset of breast cancers. These immune infiltrates, comprised cells from the innate and adaptive immune response, can be detected and characterized in biopsy specimens and have prognostic value. Tumor-infiltrating lymphocytes (TILs) represent the majority of mononuclear immune infiltrates in the breast tumor microenvironment and can be easily identified in formalin-fixed paraffin-embedded tissues after standard hematoxylin and eosin staining...
January 2017: Breast Cancer: the Journal of the Japanese Breast Cancer Society
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