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Breast Cancer: the Journal of the Japanese Breast Cancer Society

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https://www.readbyqxmd.com/read/30617938/association-of-insulin-like-growth-factor-1-receptor-and-estrogen-receptor-with-pathological-complete-response-to-neoadjuvant-chemotherapy-in-her2-negative-breast-cancer
#1
Lei Liu, Yunhui Hu, Sheng Zhang, Xiru Li, Jin Zhang
PURPOSE: To investigate the association of insulin like growth factor 1 receptor (IGF-1R) and estrogen receptor (ER) with pathological complete response (pCR) secondary to neoadjuvant chemotherapy in human epidermal growth factor receptor-2 (HER2)-negative breast cancer. MATERIALS AND METHODS: The immunohistochemical expressions of IGF-1R and ER were detected in puncture specimens from 273 patients who received neoadjuvant chemotherapy. Association of IGF-1R and ER expression with pCR to neoadjuvant chemotherapy was evaluated...
January 8, 2019: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/30617675/nomogram-to-predict-non-sentinel-lymph-node-status-using-total-tumor-load-determined-by-one-step-nucleic-acid-amplification-first-report-from-thailand
#2
Doonyapat Sa-Nguanraksa, Eng O-Charoenrat, Anchalee Kulprom, Norasate Samarnthai, Visnu Lohsiriwat, Kampanart Nimpoonsri, Pornchai O-Charoenrat
BACKGROUND: Axillary staging is a significant prognostic factor often used to determine the treatment course for breast cancer. One-step nucleic acid amplification (OSNA) is now the most accepted method for intra-operative assessment of sentinel lymph nodes (SLN) as it can semi-quantitatively determine the tumor burden in these SLN. Axillary lymph node dissection (ALND) may be omitted in patients with limited disease in the axilla. The objective was to create nomogram for prediction of non-sentinel lymph node (NSLN) status using OSNA to avoid unnecessary ALND...
January 7, 2019: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/30610551/cancer-stem-like-properties-of-hormonal-therapy-resistant-breast-cancer-cells
#3
Kanami Uchiumi, Kouki Tsuboi, Nozomi Sato, Takako Ito, Hisashi Hirakawa, Toshifumi Niwa, Yuri Yamaguchi, Shin-Ichi Hayashi
BACKGROUND: Presently, hormonal therapy targeting estrogen receptors is the most effective treatment available for luminal breast cancer. However, many patients relapse after the therapy. It has been suggested that cancer stem-like cells are involved with hormonal therapy resistance; in the present study, we evaluated this hypothesis. METHODS: In the present study, we used our previously established hormonal therapy-resistant cell lines, including aromatase inhibitor (AI)-resistant cells (Type 1 and Type 2) and fulvestrant-resistant cells (MFR)...
January 4, 2019: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/30604398/breast-cancer-incidence-mortality-and-mortality-to-incidence-ratio-mir-are-associated-with-human-development-1990-2016-evidence-from-global-burden-of-disease-study-2016
#4
Rajesh Sharma
OBJECTIVE: To examine breast cancer burden in females using incidence, mortality and mortality-to-incidence ratio (MIR) and its association with human development. METHODS: We employ the data of breast cancer in females from the Global Burden of Disease 2016 study for the period 1990 to 2016 for 102 countries. Human development is measured using the human development index (HDI). 5-year survival rate of breast cancer is proxied using the mortality-to-incidence ratio (MIR)...
January 2, 2019: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/30604397/quantitative-assessment-and-risk-factors-for-chest-wall-deformity-resulting-from-tissue-expansion-for-breast-reconstruction
#5
Takaya Makiguchi, Daisuke Atomura, Hideharu Nakamura, Takaaki Fujii, Satoshi Yokoo
BACKGROUND: Chest wall deformity after tissue expansion for breast reconstruction is less recognized than complications such as infection, hematoma, skin necrosis and capsular contracture. However, the condition should not be discounted because pain, rib fracture and dyspnea may occur in severe cases. The aim of this study is to evaluate the extent of chest wall deformity quantitatively using computed tomography (CT) and to identify risk factors for this condition after tissue expansion...
January 2, 2019: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/30591993/atypical-ductal-hyperplasia-and-the-risk-of-underestimation-tissue-sampling-method-multifocality-and-associated-calcification-significantly-influence-the-diagnostic-upgrade-rate-based-on-subsequent-surgical-specimens
#6
Christoph J Rageth, Ravit Rubenov, Cristian Bronz, Daniel Dietrich, Christoph Tausch, Ann-Katrin Rodewald, Zsuzsanna Varga
BACKGROUND: Risk assessment and therapeutic options are challenges when counselling patients with an atypical ductal hyperplasia (ADH) to undergo either open surgery or follow-up only. METHODS: We retrospectively analyzed a series of ADH lesions and assessed whether the morphological parameters of the biopsy materials indicated whether the patient should undergo surgery. A total of 207 breast biopsies [56 core needle biopsies (CNBs) and 151 vacuum-assisted biopsies (VABs)] histologically diagnosed as ADH were analyzed retrospectively, together with subsequently obtained surgical specimens...
December 27, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/30564995/post-surgical-pyoderma-gangrenosum-of-the-breast-needs-for-early-diagnosis-and-right-therapy
#7
Giorgia Guaitoli, Federico Piacentini, Claudia Omarini, Alessia Andreotti, Enza Palma, Simona Papi, Chiara De Pietri, Andrea Conti, Stefano Cascinu, Giovanni Tazzioli
Post-surgical pyoderma gangrenosum (PSPG) of the breast is a rare dermatosis that worsens surgical manipulation, with a chronical relapsing course. Diagnosis is mostly clinical and made by exclusion after the failure of antibiotic therapies and surgical debridement, while the mainstay of therapy is corticosteroid-based. Here we report a case of PSPG of the breast in a young woman with breast cancer, to emphasize the needs of an early and accurate diagnosis, to guarantee the most efficacious treatment and to avoid life-threatening complications...
December 18, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/30543015/toll-like-receptor-4-and-breast-cancer-an-updated-systematic-review
#8
REVIEW
Morteza Khademalhosseini, Mohammad Kazemi Arababadi
Toll-like receptors (TLRs) may play dual roles in human cancers. TLR4 is a key molecule which may participate in both friend and foe roles against breast cancer. This review article collected recent data regarding the mechanisms used by TLR4 in the eradication of breast cancer cells and induction of the tumor cells, and discussed the mechanisms involved in the various functions of TLR4. The literature searches revealed that TLR4 is a key molecule that participates in breast cancer cell eradication or induction of breast cancer development and also transformation of the normal cells...
December 12, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/30539373/invasive-breast-cancers-in-adolescent-and-young-adult-women-show-more-aggressive-immunohistochemical-and-clinical-features-than-those-in-women-aged-40-44-years
#9
Ai Hironaka-Mitsuhashi, Hitoshi Tsuda, Masayuki Yoshida, Chikako Shimizu, Sota Asaga, Takashi Hojo, Kenji Tamura, Takayuki Kinoshita, Toshikazu Ushijima, Nobuyoshi Hiraoka, Yasuhiro Fujiwara
BACKGROUND: Limited knowledge exists concerning the clinicopathological features of breast cancers (BCs) occurring in adolescent and young adult (AYA) women. We evaluated tumor characteristics in AYA women in comparison with those in middle-aged premenopausal women. METHODS: From consecutive AYA patients (< 35-year-old) with invasive BC in a single institute, 82 patients first treated with surgery were examined. As the control group, 82 tumors from middle-aged premenopausal patients (40-44 years) were selected by matching pathological T and N factors...
December 11, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/30535581/mutation-screening-of-tp53-chek2-and-brca-genes-in-patients-at-high-risk-for-hereditary-breast-and-ovarian-cancer-hboc-in-brazil
#10
Nilson Moreira Cipriano, Amanda Marques de Brito, Eneida Santos de Oliveira, Fabiana Castro de Faria, Sara Lemos, Angélica Nogueira Rodrigues, Débora de Oliveira Lopes, Luciana Lara Dos Santos
BACKGROUND: Few studies related to hereditary breast and ovarian cancer syndrome (HBOC) have been conducted in Brazil, and they are restricted to only small areas of the country. Here, we report the mutation profile of BRCA1/2, CHEK2 and TP53 genes in a cohort from Minas Gerais state. METHODS: These genes from 44 patients at high risk for HBOC were screened through high-resolution melting and/or sequencing. The pathogenicity of the alterations was checked using ClinVar database and bioinformatics programs...
December 11, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/30519923/apocrine-papillary-lesion-comparison-of-pathological-findings-from-22-years-previously-and-the-present
#11
Yuki Nomoto, Heiji Yoshinaka, Yasuyo Ohi, Naoki Hayashi, Ayako Nagata, Kazunobu Sueyoshi, Yuka Eguchi, Yoshiaki Shinden, Yuko Kijima, Shoji Natsugoe
Apocrine papillary lesion (APL) is difficult to diagnose as benign or malignant. We experienced an APL remaining in the body for 22 years. We present a case of a 71-year-old woman who had undergone excisional biopsy 22 years previously at the first hospital that she visited. 1 year previously, she had undergone fine-needle aspiration cytology at a second hospital, and the lesion was diagnosed as potentially malignant. She underwent core-needle biopsy at a third hospital, but whether the lesion was benign or malignant could not be definitively diagnosed...
December 5, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/30499025/p110%C3%AE-and-p110%C3%AE-isoforms-of-pi3k-are-involved-in-protection-against-h-2-o-2-induced-oxidative-stress-in-cancer-cells
#12
Paramjeet Singh, Nasima Bano, Md Mehedi Hossain, Rafia Basit, Mohd Jamal Dar
PURPOSE: Phosphatidylinositol-3 kinases (PI3Ks) are involved in regulating cell growth, proliferation, differentiation, apoptosis and survival. p110α and p110β, two ubiquitously expressed isoforms of PI3K signalling, are involved in growth factor mediated signaling and survival by generating second messengers. Earlier, we have generated GFP-fusion proteins of p110α and p110β and expressed them in normal and cancer cell-lines to investigate their subcellular localization and their role in various activities...
November 29, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/30446972/clinicopathological-features-of-breast-cancer-in-japanese-female-patients-with-lynch-syndrome
#13
Nobuhiko Kanaya, Kohji Tanakaya, Rie Yamasaki, Takashi Arata, Kunitoshi Shigeyasu, Hideki Aoki, Toshiaki Morito, Hiromi Sanaii, Kiwamu Akagi, Toshiyoshi Fujiwara
BACKGROUND: Lynch syndrome (LS) is a predominantly inherited syndrome caused by a pathological germline mutation in one of the mismatch repair (MMR) genes. Whether breast cancer (BC) is one of the LS-associated tumors is controversial. The aim of this retrospective cohort study was to evaluate the clinical features of BC in Japanese patients with LS. METHODS: Of 38 mutation carriers, 4 females with BC were examined in this study. RESULTS: Two of the four patients had multiple BC...
November 16, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/30446971/identification-of-differentially-expressed-genes-and-typical-fusion-genes-associated-with-three-subtypes-of-breast-cancer
#14
Rong Wang, Jinbin Li, Chunyu Yin, Di Zhao, Ling Yin
BACKGROUND: This study aimed to identify the differentially expressed genes (DEGs) and the typical fusion genes in different types of breast cancers using RNA-seq. METHODS: GSE52643 was downloaded from Gene Expression Omnibus, which included 1 normal sample (MCF10A) and 7 breast cancer samples (BT-474, BT-20, MCF7, MDA-MB-231, MDA-MB-468, T47D, and ZR-75-1). The transcript abundance and the DEGs screening were performed by Cufflinks. The functional and pathway enrichment was analyzed by Gostats...
November 16, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/30430339/breast-cancer-risk-associated-with-brca1-2-variants-in-the-pakistani-population
#15
Saba Abbas, Ayesha Siddique, Naeem Shahid, Rabbia Tariq Khan, Warda Fatima
BACKGROUND: Majority of the BRCA1 and BRCA2 mutations are associated with the risk of sporadic and familial breast cancer. Since these genes are significant in DNA repair mechanisms, we focused homology-directed DNA repair (HDDR) and BRCA complex. METHODS: We selected BRCA1 variant (rs80356932, 4491C/T) and BRCA2 variant (rs80359182, 319T/C) from the interaction region of BRCA complex and studied in 100 breast cancer patients and 100 controls using tetra-ARMS-PCR...
November 14, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/30387023/can-quantitative-evaluation-of-mammographic-breast-density-volumetric-measurement-predict-the-masking-risk-with-dense-breast-tissue-investigation-by-comparison-with-subjective-visual-estimation-by-japanese-radiologists
#16
Mikinao Oiwa, Tokiko Endo, Namiko Suda, Takako Morita, Yasuyuki Sato, Tomonori Kawasaki, Shu Ichihara
BACKGROUND: Sensitivity to detect breast cancer (BC) is not high in a dense breast due to masking in mammography. To evaluate the breast density, a volumetric measurement system has been recently developed that measures the percent fibroglandular tissue volume (percent FGV, hereafter termed as "FG%") to the breast volume (BV). This study was designed to investigate whether evaluation using FG% can accurately predict the masking risk by comparing with the current standard method of subjective visual estimation (SVE)...
November 1, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/30367358/ofs-plus-ai-or-serm-vs-serm-alone-in-premenopausal-women-with-hormone-receptor-positive-breast-cancer-a-prospective-cohort-study-using-the-real-world-database
#17
Kejia Hu, Ping He, Qian Peng, Xiaorong Zhong, Ling Deng, Yuxin Xie, Jiayuan Li, Hongping Xu, Donghao Lu, Hong Zheng
BACKGROUND: Ovarian function suppression (OFS) plus other endocrine treatment was recommended to hormone receptor (HR)-positive breast cancer by some guidelines recently. We performed this study to validate the survival benefits of OFS plus aromatase inhibitors (AI) or selective estrogen receptor modulators (SERM) in the real world. METHODS: All premenopausal, HR-positive breast cancer patients diagnosed between 1996 and 2017 were identified. Eligible patients were classified into three groups according to their adjuvant endocrine treatment, including OFS plus AI, OFS plus SERM and SERM alone...
October 26, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/30361832/intimacy-and-sexuality-in-women-with-breast-cancer-professional-guidance-needed
#18
Marjolein E M Den Ouden, Myrna N Pelgrum-Keurhorst, Madeleen J Uitdehaag, Hilde M De Vocht
BACKGROUND: Approximately 60-70% of breast cancer survivors experience sexuality problems resulting from treatment. This study investigated information and communication preferences with professionals on the topic intimacy and sexuality of women diagnosed with breast cancer. METHODS: Members of the Dutch Breast Cancer Patient Association were surveyed regarding their experiences and preferences about information on intimacy and sexuality. An online questionnaire was developed that included five close-ended and one open-ended question regarding: information received; type of professional preferred; method and timing of communication on the topics of intimacy and sexuality...
October 25, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/30361831/physical-activity-and-physiotherapy-perception-of-women-breast-cancer-survivors
#19
Jackeline Rangel, Maria Teresa Tomás, Beatriz Fernandes
BACKGROUND: Physical activity levels seem to play an important role on musculoskeletal disorders in women diagnosed with breast cancer. However, the effects of physical activity after diagnosis are not fully understood. Our purpose was to understand the importance of physical activity and physiotherapy on musculoskeletal disorders as a sequela of treatment in breast cancer survivor women. METHODS: For this cross-sectional study, a sample of 94 breast cancer survivor women fulfilled a self-completed questionnaire with questions on clinical and functional variables, and levels of physical activity before and after breast cancer diagnosis...
October 25, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/30350259/aldehyde-dehydrogenase-2-genotype-in-tolerability-of-alcohol-contained-in-paclitaxel-in-japanese-breast-cancer-patients
#20
Toshinari Yagi, Koto Fujiishi, Akiko Hasegawa, Tomoyuki Otsuka, Tetsuhiro Yoshinami, Minako Nishio, Fumie Fujisawa, Naotoshi Sugimoto, Fumio Imamura
BACKGROUND: Paclitaxel (PTX) is an essential anticancer drug used to treat breast cancer. Because it contains alcohol as a solvent, it is contraindicated in many Japanese breast cancer patients when they are suspected of alcohol intolerance. Aldehyde dehydrogenase 2 (ALDH2) is one of several enzymes that catalyzes dehydrogenation of aldehydes, and plays an important role in ethanol metabolism. Deficiency of this isozyme is believed to be responsible for facial flushing and other unpleasant symptoms following ethanol intake...
October 22, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
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