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Breast Cancer: the Journal of the Japanese Breast Cancer Society

Volkan Doğru, Muhittin Yaprak, Emel Durmaz, Özlenen Özkan, Ayhan Mesci, Ömer Özkan, Vahit Özmen, Cumhur Arıcı
BACKGROUND: Oncoplastic surgery has been used in breast cancer patients for better cosmetic outcome over the last decades. The aim of this prospective randomized study is to show its place in excisional breast biopsy. METHODS: An oncoplastic approach excision was compared with conventional excisional breast biopsies. The study included 80 patients, of whom half received oncoplastic intervention and half received the conventional. The primary endpoint was the cosmetic result...
July 17, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
K Okumatsu, T Tsujimoto, K Wakaba, A Seki, R Kotake, T Yamauchi, S Hirayama, H Kobayashi, H Yamauchi, K Tanaka
BACKGROUND: Decreases in cardiorespiratory fitness among breast cancer patients have often been reported in previous studies, affecting patients' health and survival. Peak oxygen uptake ([Formula: see text]) is the gold standard for assessing cardiorespiratory fitness and is inversely correlated with cardiovascular disease among women with breast cancer. Some previous studies have reported that aerobic exercise and proper diet positively influence [Formula: see text]. However, almost all studies have been conducted in the Western countries, and few studies are investigating on Asian women who have lower BMI compared with Western ones...
July 10, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
Takaya Makiguchi, Hideharu Nakamura, Takaaki Fujii, Satoshi Yokoo
PURPOSE: Nipple sparing mastectomy (NSM) for breast cancer preserves the nipple-areola complex (NAC) and has limited the extent of the scar, giving good cosmetic results. However, NAC malposition may occur. The aim of this study is to evaluate NAC malposition after NSM and to determine factors associated with malposition in two-stage reconstruction. METHODS: The subjects were 46 patients who underwent unilateral NSM, without contralateral mastopexy or reduction surgery, in two-stage reconstruction using an expander with implant or flap replacement...
July 6, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
Dachang Ma, Cheng Chen, Jun Wu, Honglei Wang, Duoming Wu
BACKGROUND: Long noncoding RNAs (lncRNAs) have been reported to play crucial roles in breast cancer. This study aimed to determine the clinical significance and biological functions of lncRNA AFAP1-AS1 in breast cancer. METHODS: The expression of AFAP1-AS1 in breast cancer tissue and adjacent normal tissue from 160 patients and breast cancer cell lines were determined by qRT-PCR. The clinical characteristics of patients were collected to analyse the correlation between AFAP1-AS1 expression and malignancy status...
July 5, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
Eriko Tokunaga, Aya Fujita, Katsumi Takizawa, Kimiko Baba, Sayuri Akiyoshi, Yoshiaki Nakamura, Hideki Ijichi, Takanobu Masuda, Chinami Koga, Wakako Tajiri, Shinji Ohno, Kenichi Taguchi, Mayumi Ishida
BACKGROUND: Neoadjuvant chemotherapy (NAC) is the standard therapeutic strategy for triple-negative breast cancer (TNBC). TNBC patients with residual disease after NAC have a significantly worse survival than those with pathological complete response (pCR); however, there is no apparent prognostic factor for non-pCR patients. Cancer stemness or epithelial-mesenchymal transition (EMT) might influence the sensitivity to chemotherapy. PATIENTS AND METHODS: Forty-eight patients with TNBC who were treated with NAC were available were included in this study...
July 3, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
Xuan Shao, Bo Sun, Yanwen Shen
In the past decades, breast surgeons have changed the clinical practice in the surgical treatment of breast cancer, by performing sentinel lymph node biopsy (SLNB) instead of performing axillary lymph node dissection (ALND) in axillary lymph node clinically negative breast cancer patients. ALND can also be avoided in SLN-positive patients who meet the Z-0011 criteria. However, the postoperative complications of SLNB and ALND, such as the secondary upper extremity lymphedema, are common and need effective solutions to prevent as soon as possible...
June 30, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
Toru Morioka, Naoki Niikura, Nobue Kumaki, Shinobu Masuda, Takayuki Iwamoto, Kozue Yokoyama, Rin Ogiya, Risa Oshitanai, Mayako Terao, Banri Tsuda, Takuho Okamura, Yuki Saito, Yasuhiro Suzuki, Yutaka Tokuda
BACKGROUND: Routine analysis of Ki-67 is not widely recommended for clinical decision-making because of poor reproducibility. Furthermore, counting numerous cells can be laborious for pathologists. Digital image analysis for immunohistochemical analysis was recently developed; however, the clinical efficacy of the Ki-67 index obtained using image analysis is unknown. METHODS: We retrospectively identified female patients with breast cancer with immunohistochemical Ki-67 and survival data using the pathology database at the Tokai University, Japan...
June 29, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
Asaka Wada, Naoki Hayashi, Fumi Endo, Hiroko Tsunoda, Atsushi Yoshida, Koyu Suzuki, Seigo Nakamura, Hideko Yamauchi
BACKGROUND: This study aimed to assess their characteristics and clinical course of each histologic type of the behavior of phyllodes tumor (PT). METHODS: We retrospectively reviewed 124 patients with PTs who underwent surgical treatment from 2003 to 2011. PTs were classified as benign, borderline, and malignant using surgical specimens. The clinicopathological characteristics according to solitary and multiple lesions on ipsilateral breast and histological change after local recurrence were examined...
June 27, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
Xiang Peng, Bin Yan, Yufeng Shen
BACKGROUND: MiRNAs regulate a variety of biological processes, such as cell proliferation and apoptosis and play critical roles in cancer progression. Accumulating studies have demonstrated that miR-1301-3p could regulate the development and progression of multiple cancers, but its biological behaviors in breast cancer (BC) are still elusive. METHODS: The expression of miR-1301-3p was determined in BC tissues and cell lines using quantitative real-time PCR analysis...
June 27, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
Junichi Kurebayashi, Naoki Kanomata, Yoshikazu Koike, Yusuke Ohta, Wataru Saitoh, Emi Kishino
BACKGROUND: The hedgehog (Hh) signaling pathway plays important roles in cell proliferation, malignant progression, invasion and metastasis, and the expansion of cancer stem cells (CSCs). Comprehensive immunohistochemical (IHC) analyses have not yet been conducted on the expression levels of Hh signaling molecules in breast cancer tissues. METHODS: A total of 204 patients with invasive breast cancer treated in our institute were study subjects. IHC analyses on the expression levels of the Hh signaling molecules, sonic Hh (SHH), PTCH1, GLI1, GLI2, and GLI3 and the CSC-related factor, SOX2, were investigated...
June 26, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
Jacek Zielinski, Radoslaw Jaworski, Ninela Irga-Jaworska, Michal Pikula, Michael Hunerbein, Janusz Jaskiewicz
BACKGROUND: Pathological nipple discharge (PND) is associated with serious clinical and diagnostic issues. Fiberoductoscopy (FDS) is a new diagnostic option in PND patients. This study summarizes our initial experience of FDS for the management of PND patients in a single center in Poland and assesses its safety. METHODS: A total of 256 women with PND were included in this prospective, case-controlled, single-center study between 2006 and 2014. Of the 250 patients who underwent FDS, 154 had mammary duct lesions and 96 had no visible lesions...
June 25, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
Li Liu, Bo Yin, Zhu Yi, XiuJuan Liu, ZhiQian Hu, WenChao Gao, HaiWen Yu, QingQuan Li
BACKGROUND: Cancer stem cells (CSCs) are believed to form metastases. We sought to determine whether CD70 + subpopulation in human breast cancers represents the CSCs accounting for distant metastasis. METHODS: We measured the expression levels of CD70 in breast cancer cell lines and 122 primary breast cancer samples. We characterized the functional roles of CD70 + subpopulation in distant metastasis of breast cancers. RESULTS: We observed a distinct pattern of CD70 expression in a panel of primary breast carcinoma samples, indicating that CD70 serves as a biomarker of lung-specific metastasis...
June 14, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
Daisuke Takabatake, Yukiko Kajiwara, Shoichiro Ohtani, Yoko Itano, Mari Yamamoto, Shinichiro Kubo, Masahiko Ikeda, Mina Takahashi, Fumikata Hara, Kenjiro Aogi, Shozo Ohsumi, Yutaka Ogasawara, Yoshitaka Nishiyama, Hajime Hikino, Kinya Matsuoka, Yuko Takahashi, Tadahiko Shien, Naruto Taira, Hiroyoshi Doihara
BACKGROUND: Perioperative dose-dense chemotherapy (DDCT) with granulocyte-colony stimulating factor (G-CSF) prophylaxis is a standard treatment for patients with high-risk breast cancer. The approval of this approach in Japan led to the widespread adoption of DDCT, despite limited efficacy and safety data among Japanese patients. We evaluated the efficacy and safety of neoadjuvant DDCT for Japanese patients with breast cancer. METHODS: This prospective, multicenter, phase II study evaluated 52 women with operable human epidermal growth factor receptor 2-negative breast cancer and axillary lymph node metastasis...
June 11, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
Tatsuya Toyama, Akiyo Yoshimura, Takako Hayashi, Naomi Kobayashi, Kanako Saito, Michiko Tsuneizumi, Masataka Sawaki, Masaya Hattori, Takumi Nakada, Isao Yokota, Hiroji Iwata
BACKGROUND: Pyridoxine, an activated form of vitamin B6 used to treat allergic dermatitis, may prevent capecitabine-associated hand-foot syndrome (HFS), although evidence of the benefit of prophylactic pyridoxine is lacking. The aim of this open-label, multicenter, randomized phase II study was to determine whether prophylactic pyridoxine could delay the onset of capecitabine-induced HFS in patients with advanced or metastatic breast cancer. METHODS: Patients received either concomitant pyridoxine (60 mg per day; pyridoxine group), or no pyridoxine but treatment with capecitabine-containing regimens (no pyridoxine group)...
June 8, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
Omar Abdel-Rahman
BACKGROUND: This study aims to assess the patterns of development of on-treatment cardiac side effects among patients with early breast cancer receiving anthracycline-based chemotherapy. METHODS: This is a pooled analysis of patient-level data of patients with early-stage breast cancer who were recruited into three clinical trials to receive different adjuvant chemotherapy regimens. Univariable and multivariable analyses of factors predicting the development of on-treatment cardiac adverse events were conducted through logistic regression analysis...
June 7, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
Tahani Louhichi, Sonia Ziadi, Hanene Saad, Myriam Ben Dhiab, Sarra Mestiri, Mounir Trimeche
BACKGROUND: CD44 and aldehyde dehydrogenase 1 (ALDH1) has been reputed to be cancer stem cell (CSC) markers in breast cancer. Yet, the clinicopathologic and prognostic significance of these markers remain unclear. In this study, we have investigated the expression of these markers and their relation with conventional clinicopathologic tumor characteristic including molecular subtype. METHODS: CD44 and ALDH1 expression were investigated by immunohistochemistry in a series of 157 formalin-fixed paraffin-embedded breast cancer tissues...
May 29, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
Lan Gao, Shu-Chuen Li
OBJECTIVES: To examine the cost-effectiveness of lipegfilgrastim versus pegfilgrastim as primary prophylaxis in women with early stage breast cancer. METHODS: Two Markov models including a chemotherapy and a post-chemotherapy models were constructed with a time horizon of 12 weeks and 30 years, respectively. All the transition probabilities and utility weights were derived from clinical trials and/or published literatures. The costs populated in the chemotherapy model were extracted from Medicare, Pharmaceutical Benefit Scheme and the Independent Hospital Pricing Authority...
May 25, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
Lijuan Wen, Lei Liu, Lina Wen, Tao Yu, Fengxiang Wei
BACKGROUND: Recent studies have revealed that artesunate (ART) has clear anti-tumor activity, suggesting that it could be a good candidate chemotherapeutic agent. In this study, we researched the inhibitory effect of ART on MCF7 cells and explored the possible mechanisms. METHODS: MTT assay was used to detect the effect of ART on the proliferation of MCF7 cells. Crystal violet staining was used to observe morphological and quantitative changes. Flow cytometry was used to detect the cell cycle of the drug-acting MCF7 cells...
May 24, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
Yekaterina O Ostapchuk, Yuliya V Perfilyeva, Elena A Kustova, Natalya T Urazalieva, Nazgul A Omarbaeva, Shynar G Talaeva, Nikolai N Belyaev
BACKGROUND: Regulatory T cells (Tregs) play a major role in tumor escape from immunosurveillance by suppressing effector cells. The number of Tregs is increased in tumor sites and peripheral blood of breast cancer patients. However, the data regarding phenotypic and functional heterogeneity of Treg subpopulations in breast cancer are limited. The present study aimed to investigate the number and suppressive potential of Tregs that possess natural naïve-(N nTregs), effector/memory-like (EM nTregs), and Tr1-like phenotypes in breast cancer patients and healthy women...
May 24, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
Sae Byul Lee, Guiyun Sohn, Jisun Kim, Il Yong Chung, Jong Won Lee, Hee Jeong Kim, Beom Seok Ko, Byung Ho Son, Sei-Hyun Ahn
BACKGROUND: We performed this study to analyze changing survival patterns regarding recurrent breast cancer in Korea during the last 16 years (1993-2008). We also sought to determine factors possibly influencing outcomes and changes over time in the duration of survival after recurrence. METHODS: We retrospectively analyzed 9671 patients with breast cancer treated between January 1993 and December 2008, comparing the periods 1993-2002 and 2003-2008.We retrospectively reviewed the collected database including the age at diagnosis, clinical manifestations, pathology report, surgical methods, types of adjuvant treatment modalities, type of recurrence, and follow-up period...
May 21, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
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