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Breast Cancer: the Journal of the Japanese Breast Cancer Society

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https://www.readbyqxmd.com/read/28211018/does-longer-disease-free-interval-affect-the-complete-remission-in-metastatic-breast-cancer
#1
LETTER
Kadri Altundag
No abstract text is available yet for this article.
February 16, 2017: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/28205133/social-impacts-of-the-work-loss-in-cancer-survivors
#2
Hideko Yamauchi, Chizuko Nakagawa, Takashi Fukuda
BACKGROUND: As cancer frequently occurs during the most productive years of life, our purpose was to estimate the cost of work loss of cancer survivors and develop interventions to minimize the loss. METHODS: We estimated the cost of the work loss from all cancers resulting from patients' inpatient, outpatient, and non-treatment days. This was calculated with a new method, the product of the "employment rate coefficient × productivity coefficient," making use of data published by the Japanese Ministries...
February 16, 2017: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/28144905/anti-cell-growth-and-anti-cancer-stem-cell-activities-of-the-non-canonical-hedgehog-inhibitor-gant61-in-triple-negative-breast-cancer-cells
#3
Yoshikazu Koike, Yusuke Ohta, Wataru Saitoh, Tetsumasa Yamashita, Naoki Kanomata, Takuya Moriya, Junichi Kurebayashi
BACKGROUND: Triple-negative breast cancer (TNBC) exhibits biologically aggressive behavior and has a poor prognosis. Novel molecular targeting agents are needed to control TNBC. Recent studies revealed that the non-canonical hedgehog (Hh) signaling pathway plays important roles in the regulation of cancer stem cells (CSCs) in breast cancer. Therefore, the anti-cell growth and anti-CSC effects of the non-canonical Hh inhibitor GANT61 were investigated in TNBC cells. METHODS: The effects of GANT61 on cell growth, cell cycle progression, apoptosis, and the proportion of CSCs were investigated in three TNBC cell lines...
January 31, 2017: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/28138801/mir-668-enhances-the-radioresistance-of-human-breast-cancer-cell-by-targeting-i%C3%AE%C2%BAb%C3%AE
#4
Ming Luo, Ling Ding, Qingjian Li, Herui Yao
BACKGROUND: A large proportion of breast cancer patients are resistant to radiotherapy, which is a mainstay treatment for this malignancy, but the mechanisms of radioresistance remain unclear. METHODS AND MATERIALS: To evaluate the role of miRNAs in radioresistance, we established two radioresistant breast cancer cell lines MCF-7R and T-47DR derived from parental MCF-7 and T-47D. Moreover, miRNA microarray, quantitative RT-PCR analysis, luciferase reporter assay and western blotting were used...
January 30, 2017: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/28108967/specific-sites-of-metastases-in-invasive-lobular-carcinoma-a-retrospective-cohort-study-of-metastatic-breast-cancer
#5
Masayuki Inoue, Hiroshi Nakagomi, Haruka Nakada, Kazushige Furuya, Kou Ikegame, Hideki Watanabe, Masao Omata, Toshio Oyama
BACKGROUND: Invasive lobular carcinoma (ILC) is known to be the second most common histological type following invasive ductal carcinoma (IDC). Definitive clinical features of ILC are controversial. METHODS: We retrospectively analyzed a cohort of 330 patients with metastatic breast cancer, 303 of IDC, 19 of ILC, and 8 of others. We compared the patient age and tumor-node-metastasis factors, disease-free survival (DFS), estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor 2 (HER2) expression at the primary site between ILC and IDC...
January 20, 2017: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/28108966/breast-reconstruction-and-postmastectomy-radiotherapy-complications-by-type-and-timing-and-other-problems-in-radiation-oncology
#6
Kenji Sekiguchi, Jiro Kawamori, Hideko Yamauchi
Breast reconstruction (BR) represents a suitable option for women who are not expected to require postmastectomy radiotherapy (PMRT). As recent evidence has led to an extension of the indications for PMRT, this has also appeared to increase the incidence of reconstructive complications. Nevertheless, in the USA at least, trends towards BR are changing. The frequency of immediate reconstruction continues to increase, even in the setting of PMRT. In immediate implant-based reconstruction, a staged approach is preferred...
January 20, 2017: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/28097458/tissue-marker-clip-placement-after-11-gauge-vacuum-assisted-stereotactic-breast-biopsy-methodological-issue-on-validity-and-reliability
#7
LETTER
Siamak Sabour
No abstract text is available yet for this article.
January 17, 2017: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/28070832/objection-to-postoperative-radiation-therapy-in-breast-cancer-with-one-to-three-lymph-nodes-involvements
#8
Takashi Ishikawa, Hiroshi Kaise, Kimito Yamada, Mari Hosonaga, Takashi Chishima, Kazutaka Narui, Akimitsu Yamada, Sadatoshi Sugae, Yasushi Ichikawa, Mitsuyoshi Ota, Miyako Nozaki, Ryuji Mikami, Koichi Tokuuye
My arguments regarding postmastectomy radiotherapy (PMRT) for this case are based on the following 4 reasons: (1) high rate of local recurrence in the no PMRT group in the Early Breast Cancer Trialists' Collaborative Group meta-analysis on which the present guideline is based, (2) stage migration by sentinel node biopsy, (3) possible adverse events of radiotherapy, and (4) problems on extrapolation of data from western countries.
January 9, 2017: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/28070831/the-prolyl-oligopeptidase-inhibitor-suam-14746-attenuates-the-proliferation-of-human-breast-cancer-cell-lines-in-vitro
#9
Satoshi Tanaka, Kanayo Suzuki, Minoru Sakaguchi
BACKGROUND: Prolyl oligopeptidase (POP, EC 3.4.1.26) is a serine peptidase that hydrolyzes post-proline peptide bonds in peptides that are <30 amino acids in length. We previously reported that POP inhibition suppressed the growth of NB-1 human neuroblastomas cells and KATO III human gastric cancer cells. POP activity is commonly elevated in many cancers, which includes breast cancer. However, the effect of POP inhibition as a candidate breast cancer therapy is unknown. METHODS: The effects of POP inhibition and knockdown on the proliferation of cultured human estrogen receptor-positive (ER+) MCF7 and T47D, and ER-negative (ER-) MDA-MB-231 breast cancer cell lines and the MCF12A non-tumorigenic epithelial cell line were tested by analyzing their influence on cell proliferation (WST-1 assay), cell viability (trypan blue exclusion assay), and cell cycle arrest (cell cycle analysis, cell cycle regulator proteins expression)...
January 9, 2017: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/28058615/complete-remission-in-metastatic-breast-cancer-expecting-the-unexpected-results-of-a-cross-sectional-study
#10
Giulia Galli, Anna Tessari, Luca Porcu, Giacomo Bregni, Biagio Paolini, Maria Luisa Carcangiu, Massimiliano Gennaro, Maria Carmen De Santis, Laura Lozza, Filippo de Braud, Serena Di Cosimo
BACKGROUND: Complete response (CR) in metastatic breast cancer (MBC) is rare. This study aims at analyzing the characteristics and outcome of MBC patients achieving CR. METHODS: We performed a cross-sectional analysis of clinical data from a consecutive series of MBC patients admitted at the Division of Medical Oncology of Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy, achieving CR following treatment for systemic disease and with at least 2 years of follow-up...
January 5, 2017: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/28058614/simultaneous-atm-brca1-rad51-expression-variations-associated-with-prognostic-factors-in-iranian-sporadic-breast-cancer-patients
#11
Zeinab Hallajian, Frouzandeh Mahjoubi, Nahid Nafissi
BACKGROUND: DNA double-strand breaks (DSBs) as a serious lesion are repaired by non-homologous end-joining and homologous recombination pathways. ATM, BRCA1, RAD51 genes are involved in HR pathways. While some studies have revealed individual expression changes of these genes in different types of cancer, there are limited studies attempting to evaluate correlation of expression variations of these genes in breast cancer pathogenesis. This study aimed to determine RAD51, ATM and BRCA1 gene expression level and its association with clinicopathological factors in fresh breast cancer tissues...
January 5, 2017: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/28050738/preoperative-neoadjuvant-chemotherapy-using-nanoparticle-albumin-bound-paclitaxel-followed-by-epirubicin-and-cyclophosphamide-for-operable-breast-cancer-a-multicenter-phase-ii-trial
#12
Manabu Futamura, Yasuko Nagao, Kazuhiro Ishihara, Makoto Takeuchi, Takumi Nakada, Yoshihiro Kawaguchi, Masayoshi Asano, Iwao Kumazawa, Takashi Shiroko, Kasumi Morimitsu, Ryutaro Mori, Masahito Nawa, Toshio Shimokawa, Kazuhiro Yoshida
BACKGROUND: Recently, the use of taxane-based regimens before anthracycline-based regimens has been shown to achieve high pathological complete response (pCR) rates in patients with breast cancer. Nanoparticle albumin-bound paclitaxel (nab-PTX) has been reported as highly effective and less toxic compared with Cremophor-based Taxol. This phase II clinical trial evaluated the safety and efficacy of preoperative neoadjuvant chemotherapy (NAC) with nab-PTX followed by an epirubicin plus cyclophosphamide (EC)-based regimen for operable breast cancer...
January 3, 2017: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/28008557/the-effects-of-complex-exercise-on-shoulder-range-of-motion-and-pain-for-women-with-breast-cancer-related-lymphedema-a-single-blind-randomized-controlled-trial
#13
Jin-Hyuck Park
BACKGROUND: This study was to investigate the effects of complex exercise on shoulder range of motion and pain for women with breast cancer-related lymphedema. METHODS: 69 women participated in this study and then they were randomly allocated to complex exercise group (n = 35) or the conventional decongestive therapy group (n = 34). All subjects received 8 sessions for 4 weeks. To identify the effects on shoulder range of motion and pain, goniometer and visual analog scale were used, respectively...
December 23, 2016: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/27943163/atypical-femoral-fracture-after-receiving-antiresorptive-drugs-in-breast-cancer-patients-with-bone-metastasis
#14
Seiya Ota, Ryo Inoue, Takashi Shiozaki, Yuji Yamamoto, Naoki Hashimoto, On Takeda, Kei Yoshikawa, Junji Ito, Yasuyuki Ishibashi
BACKGROUND: Atypical femoral fracture (AFF) occurs with minor trauma in patients receiving antiresorptive drugs such as bisphosphonate and denosumab. We hypothesized that patients with bone metastasis who receive higher doses of antiresorptive drugs tend to experience AFF more frequently. This study aimed to investigate the prevalence rate of AFF in patients receiving antiresorptive drugs for bone metastasis of breast cancer. METHODS: Based on the database from our hospital, patients with breast cancer between March and September 2014 were investigated...
December 10, 2016: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/27896661/erratum-to-breast-reconstruction-using-free-medial-circumflex-femoral-artery-perforator-flaps-intraoperative-anatomic-study-and-clinical-results
#15
Mai Shibuya, Toshihiko Satake, Reiko Nakasone, Marina Ogawa, Mayu Muto, Kazutaka Narui, Kazunori Yasumura, Takashi Ishikawa, Jiro Maegawa
No abstract text is available yet for this article.
November 28, 2016: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/27882505/antitumor-immunity-and-advances-in-cancer-immunotherapy
#16
EDITORIAL
Tomoharu Sugie, Masakazu Toi
No abstract text is available yet for this article.
January 2017: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/27605223/possible-supplemental-breast-cancer-screening-modalities
#17
EDITORIAL
Takayoshi Uematsu
No abstract text is available yet for this article.
January 2017: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/27259342/the-need-for-supplemental-breast-cancer-screening-modalities-a-perspective-of-population-based-breast-cancer-screening-programs-in-japan
#18
REVIEW
Takayoshi Uematsu
PURPOSE: This article discusses possible supplemental breast cancer screening modalities for younger women with dense breasts from a perspective of population-based breast cancer screening program in Japan. CONCLUSION: Supplemental breast cancer screening modalities have been proposed to increase the sensitivity and detection rates of early stage breast cancer in women with dense breasts; however, there are no global guidelines that recommend the use of supplemental breast cancer screening modalities in such women...
January 2017: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/27138387/immune-infiltrates-in-the-breast-cancer-microenvironment-detection-characterization-and-clinical-implication
#19
REVIEW
Samantha Burugu, Karama Asleh-Aburaya, Torsten O Nielsen
Although unlike melanoma, breast cancer is not generally viewed as a highly immunogenic cancer, recent studies have described a rich tumor immune microenvironment in a subset of breast cancers. These immune infiltrates, comprised cells from the innate and adaptive immune response, can be detected and characterized in biopsy specimens and have prognostic value. Tumor-infiltrating lymphocytes (TILs) represent the majority of mononuclear immune infiltrates in the breast tumor microenvironment and can be easily identified in formalin-fixed paraffin-embedded tissues after standard hematoxylin and eosin staining...
January 2017: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/27138386/breast-cancer-screening-with-digital-breast-tomosynthesis
#20
Per Skaane
PURPOSE: To give an overview of studies comparing full-field digital mammography (FFDM) and digital breast tomosynthesis (DBT) in breast cancer screening. MATERIALS AND METHODS: The implementation of tomosynthesis in breast imaging is rapidly increasing world-wide. Experimental clinical studies of relevance for DBT screening have shown that tomosynthesis might have a great potential in breast cancer screening, although most of these retrospective reading studies are based on small populations, so that final conclusions are difficult to draw from individual reports...
January 2017: Breast Cancer: the Journal of the Japanese Breast Cancer Society
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