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Breast Cancer: the Journal of the Japanese Breast Cancer Society

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https://www.readbyqxmd.com/read/30387023/can-quantitative-evaluation-of-mammographic-breast-density-volumetric-measurement-predict-the-masking-risk-with-dense-breast-tissue-investigation-by-comparison-with-subjective-visual-estimation-by-japanese-radiologists
#1
Mikinao Oiwa, Tokiko Endo, Namiko Suda, Takako Morita, Yasuyuki Sato, Tomonori Kawasaki, Shu Ichihara
BACKGROUND: Sensitivity to detect breast cancer (BC) is not high in a dense breast due to masking in mammography. To evaluate the breast density, a volumetric measurement system has been recently developed that measures the percent fibroglandular tissue volume (percent FGV, hereafter termed as "FG%") to the breast volume (BV). This study was designed to investigate whether evaluation using FG% can accurately predict the masking risk by comparing with the current standard method of subjective visual estimation (SVE)...
November 1, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/30367358/ofs-plus-ai-or-serm-vs-serm-alone-in-premenopausal-women-with-hormone-receptor-positive-breast-cancer-a-prospective-cohort-study-using-the-real-world-database
#2
Kejia Hu, Ping He, Qian Peng, Xiaorong Zhong, Ling Deng, Yuxin Xie, Jiayuan Li, Hongping Xu, Donghao Lu, Hong Zheng
BACKGROUND: Ovarian function suppression (OFS) plus other endocrine treatment was recommended to hormone receptor (HR)-positive breast cancer by some guidelines recently. We performed this study to validate the survival benefits of OFS plus aromatase inhibitors (AI) or selective estrogen receptor modulators (SERM) in the real world. METHODS: All premenopausal, HR-positive breast cancer patients diagnosed between 1996 and 2017 were identified. Eligible patients were classified into three groups according to their adjuvant endocrine treatment, including OFS plus AI, OFS plus SERM and SERM alone...
October 26, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/30361832/intimacy-and-sexuality-in-women-with-breast-cancer-professional-guidance-needed
#3
Marjolein E M Den Ouden, Myrna N Pelgrum-Keurhorst, Madeleen J Uitdehaag, Hilde M De Vocht
BACKGROUND: Approximately 60-70% of breast cancer survivors experience sexuality problems resulting from treatment. This study investigated information and communication preferences with professionals on the topic intimacy and sexuality of women diagnosed with breast cancer. METHODS: Members of the Dutch Breast Cancer Patient Association were surveyed regarding their experiences and preferences about information on intimacy and sexuality. An online questionnaire was developed that included five close-ended and one open-ended question regarding: information received; type of professional preferred; method and timing of communication on the topics of intimacy and sexuality...
October 25, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/30361831/physical-activity-and-physiotherapy-perception-of-women-breast-cancer-survivors
#4
Jackeline Rangel, Maria Teresa Tomás, Beatriz Fernandes
BACKGROUND: Physical activity levels seem to play an important role on musculoskeletal disorders in women diagnosed with breast cancer. However, the effects of physical activity after diagnosis are not fully understood. Our purpose was to understand the importance of physical activity and physiotherapy on musculoskeletal disorders as a sequela of treatment in breast cancer survivor women. METHODS: For this cross-sectional study, a sample of 94 breast cancer survivor women fulfilled a self-completed questionnaire with questions on clinical and functional variables, and levels of physical activity before and after breast cancer diagnosis...
October 25, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/30350259/aldehyde-dehydrogenase-2-genotype-in-tolerability-of-alcohol-contained-in-paclitaxel-in-japanese-breast-cancer-patients
#5
Toshinari Yagi, Koto Fujiishi, Akiko Hasegawa, Tomoyuki Otsuka, Tetsuhiro Yoshinami, Minako Nishio, Fumie Fujisawa, Naotoshi Sugimoto, Fumio Imamura
BACKGROUND: Paclitaxel (PTX) is an essential anticancer drug used to treat breast cancer. Because it contains alcohol as a solvent, it is contraindicated in many Japanese breast cancer patients when they are suspected of alcohol intolerance. Aldehyde dehydrogenase 2 (ALDH2) is one of several enzymes that catalyzes dehydrogenation of aldehydes, and plays an important role in ethanol metabolism. Deficiency of this isozyme is believed to be responsible for facial flushing and other unpleasant symptoms following ethanol intake...
October 22, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/30341748/identification-of-genes-associated-with-survival-of-breast-cancer-patients
#6
Min Liu, Siying Zhou, Jinyan Wang, Qian Zhang, Sujin Yang, Jifeng Feng, Bin Xu, Shanliang Zhong
BACKGROUND: We aimed to investigate the potential of microRNA expression profiles to predict survival in breast cancer. METHODS: MicroRNA and mRNA expression data of breast cancer were downloaded from The Cancer Genome Atlas. LASSO regression was used to identify microRNAs signature predicting survival of breast cancer patients. Transfection experiment was conducted to explore the influence of microRNAs on their potential targets. RESULTS: We identified 56 differentially expressed microRNAs in breast cancer tissues compared to adjacent normal tissues...
October 19, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/30341747/hypofractionated-whole-breast-radiotherapy-with-or-without-hypofractionated-boost-in-early-stage-breast-cancer-patients-a-mono-institutional-analysis-of-skin-and-subcutaneous-toxicity
#7
Isabella Palumbo, Cristina Mariucci, Lorenzo Falcinelli, Elisabetta Perrucci, Valentina Lancellotta, Anna Maria Podlesko, Marta Marcantonini, Simonetta Saldi, Vittorio Bini, Cynthia Aristei
BACKGROUND: Our study evaluated skin and subcutaneous toxicity analyzing its correlation with patient- and treatment-related factors in a large mono-institutional series of women with early stage breast cancer treated with adjuvant hypofractionated whole breast radiotherapy (WBRT) with or without a sequential hypofractionated boost (HB). METHODS: Two hundred and nineteen patients, median age 62 years, received adjuvant hypofractionated WBRT in 16 fractions to a total dose of 42...
October 19, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/30328007/the-decision-to-perform-or-omit-sentinel-lymph-node-biopsy-during-mastectomy-for-ductal-carcinoma-in-situ-should-be-tailored-in-accordance-with-preoperative-findings
#8
LETTER
Yusuke Watanabe, Keisei Anan
No abstract text is available yet for this article.
October 16, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/30328006/compensatory-role-of-insulin-like-growth-factor-1-receptor-in-estrogen-receptor-signaling-pathway-and-possible-therapeutic-target-for-hormone-therapy-resistant-breast-cancer
#9
Masafumi Iida, Kouki Tsuboi, Toshifumi Niwa, Takanori Ishida, Shin-Ichi Hayashi
BACKGROUND: Hormone therapy targeting the estrogen receptor (ER) pathway is the most common treatment used for ER-positive breast cancer. However, some patients experience de novo or acquired resistance, which becomes a critical problem. Activation of the insulin-like growth factor (IGF) pathway allows breast cancer cells to proliferate and is associated with the ER pathway. Little is known about the role of the IGF pathway in hormone therapy and resistance; therefore, we investigated whether the inhibition of this pathway may represent a novel therapeutic target for overcoming hormone therapy resistance in ER-positive breast cancers...
October 16, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/30324552/oligometastatic-breast-cancer
#10
REVIEW
Dorota Kwapisz
Metastatic breast cancer (MBC) is considered as incurable. The group of patients with oligometastatic disease (a few metastatic lesions and organs involved) apparently have better prognosis. It is claimed that, these patients could be treated with curative intent, and multidisciplinary aggressive approach should be considered. Despite the lack of strong data it is increasingly accepted in clinical practice. Currently, the appropriate candidate would be young woman with good performance status, low tumour burden with long disease-free interval...
October 15, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/30324551/chemotherapy-induced-peripheral-neuropathy-in-breast-cancer-patients-treated-with-eribulin-interim-data-from-a-post-marketing-observational-study
#11
Junji Tsurutani, Yukinori Sakata, Toshiyuki Matsuoka
BACKGROUND: Few studies have examined chemotherapy-induced peripheral neuropathy (CIPN) following the administration of eribulin as first- or second-line therapy in patients with breast cancer. We therefore assessed CIPN incidence by severity and risk factors for CIPN in patients treated with eribulin for HER2-negative inoperable or recurrent breast cancer, regardless of line therapy status. METHODS: This multicenter, prospective, post-marketing observational study enrolled patients from September 2014 in Japan and followed them for 2 years...
October 15, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/30317464/gene-expression-profile-of-peripheral-blood-mononuclear-cells-may-contribute-to-the-identification-and-immunological-classification-of-breast-cancer-patients
#12
Eiji Suzuki, Masahiro Sugimoto, Kosuke Kawaguchi, Fengling Pu, Ryuji Uozumi, Ayane Yamaguchi, Mariko Nishie, Moe Tsuda, Takeshi Kotake, Satoshi Morita, Masakazu Toi
BACKGROUND: It has been reported that the gene expression profile of peripheral blood mononuclear cells (PBMCs) exhibits a unique gene expression signature in several types of cancer. In this study, we aimed to explore the breast cancer patient-specific gene expression profile of PBMCs and discuss immunological insight on host antitumor immune responses. METHODS: We comprehensively analyzed the gene expression of PBMCs by RNA sequencing in the breast cancer patients as compared to that of healthy volunteers (HVs)...
October 13, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/30284194/additive-effect-of-metastamir-193b-and-breast-cancer-metastasis-suppressor-1-as-an-anti-metastatic-strategy
#13
Zahra Sadat Hashemi, Mehdi Forouzandeh Moghadam, Saeed Khalili, Mahlegha Ghavami, Fatemeh Salimi, Esmaeil Sadroddiny
BACKGROUND: It has been reported that enhancing the cellular levels of miR-193b as well as breast cancer-metastasis-suppressor-1 (BRMS1) protein is associated with diminished metastatic characteristics in breast cancer. In view of these facts, as a new therapeutic intervention, we employed a restoration-based strategy using both miR-193b-3p mimic and optimized BRMS1 in the context of a chimeric construct. METHODS: miR-193b-3p and BRMS1 genes were cloned and the resulting plasmids were transfected into the MDA-MB231, MCF-7 and MCF-10A cell lines...
October 3, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/30259414/validation-of-an-information-motivation-behavioral-skills-model-of-upper-limb-functional-exercise-adherence-among-chinese-postoperative-patients-with-breast-cancer
#14
Xige Wang, Minghua Jia, Yuewei Li, Yinan Bao, Chengshuai Zhang, Changli Zhou, Li Wang, Xiaobai Cao, Ruxin Jiang, Feng Li
BACKGROUND: The adherence to postoperative upper limb functional exercise in breast cancer (BC) patients is poor which can lead to adverse health outcomes. Effective intervention content to improve adherence is still unclear. The information-motivation-behavioral skills (IMB) model is a theoretical model that has been widely used to promote health behavior in many disease populations and may, therefore, help to explain and promote adherence to functional exercise. In this study, we validated the IMB model in a sample of postoperative BC patients...
September 27, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/30259332/does-breast-cancer-growth-rate-really-depend-on-tumor-subtype-measurement-of-tumor-doubling-time-using-serial-ultrasonography-between-diagnosis-and-surgery
#15
Kazuaki Nakashima, Takayoshi Uematsu, Kaoru Takahashi, Seiichirou Nishimura, Yukiko Tadokoro, Tomomi Hayashi, Takashi Sugino
BACKGROUND: Breast cancer growth is generally expected to differ between tumor subtypes. We aimed to evaluate tumor doubling time (DT) using ultrasonography and verify whether each tumor subtype has a unique DT. METHODS: This retrospective study included 265 patients with invasive breast cancer who received serial ultrasonography between diagnosis and surgery. Tumor diameters were measured in three directions and DTs were calculated according to an exponential growth model using the volume change during serial ultrasonography...
September 26, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/30259331/griffipavixanthone-induces-apoptosis-of-human-breast-cancer-mcf-7-cells-in-vitro
#16
Yanchun Ma, Yi Wang, Bin Song
BACKGROUND: Griffipavixanthone (GPX) is a compound extracted from Garcinia oblongifolia Champ. But, no research has yet been done about the effect of GPX on breast cancer. METHODS: We evaluated the proliferation of human breast cancer cells by CCK-8 assay and apoptosis by Annexin V (AV)-FITC and PI double staining. We used transwell assay to indicate the invasion and migration of MCF-7. To explore the molecular mechanism of GPX, we detected the mRNA and protein expression using qRT-PCR and Western blot...
September 26, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/30255294/p21-waf1-cip1-its-paradoxical-effect-in-the-regulation-of-breast-cancer
#17
REVIEW
Samir F Zohny, Abdulrahman L Al-Malki, Mazin A Zamzami, Hani Choudhry
p21Waf1/Cip1 , the cyclin-dependent kinase (CDK) inhibitor belonging to the KIP/CIP family, was initially regarded as a tumor suppressor protein because it was recognized as the chief mediator of p53-dependent cell cycle arrest elicited by DNA damage. Conversely, it has been proposed that p21Waf1/Cip1 may also function as an oncogene because it can inhibit apoptosis. Thus, p21Waf1/Cip1 is regarded as a protein with a dual behavior, as its expression might cause potential benefits or dangerous effects in breast cancer...
September 25, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/30244409/coexistence-of-regulatory-b-cells-and-regulatory-t-cells-in-tumor-infiltrating-lymphocyte-aggregates-is-a-prognostic-factor-in-patients-with-breast-cancer
#18
Emi Ishigami, Masahiro Sakakibara, Junta Sakakibara, Takahito Masuda, Hiroshi Fujimoto, Shouko Hayama, Takeshi Nagashima, Takafumi Sangai, Ayako Nakagawa, Yukio Nakatani, Masayuki Otsuka
BACKGROUND: Tumors can acquire tolerance to tumor immunity and develop enhanced proliferation. Regulatory B cells (Bregs), whose role in immune tolerance is similar to that of regulatory T cells (Tregs), appear to be involved in tumor immunity. Recently, Bregs were found to induce Tregs against tumor immunity. However, the platform for the coexistence of Bregs and Tregs in cancer patients and its clinical significance remain unclear; thus, they were evaluated in breast cancer patients...
September 22, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/30242783/correction-to-chemotherapy-and-targeted-therapy-for-breast-cancer-patients-with-hepatitis-c-virus-infection
#19
Soha Talima, Hebatallah Kassem, Neemat Kassem
The online version of the original article can be found.
September 21, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/30229499/clinico-radiologic-features-and-management-of-hematological-tumors-in-the-breast-a-case-series
#20
Joseph T Hoang, Robert Yang, Zeeshan A Shah, Joseph J Spigel, John E Pippen
Hematological tumors arising in the breast are uncommon and require different treatment modalities dependent upon tumor type. Current treatment options include surgical excision, chemotherapy, and radiotherapy. Management of these breast malignancies are poorly outlined in the literature. The purpose of this case series is to report five cases consisting of extranodal marginal zone lymphoma, lymphoplasmacytic lymphoma, and extramedullary plasmacytoma occurring in the breast. The cases illustrate heterogeneous radiologic findings and varying management approaches to these tumors...
September 18, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
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