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Human Fertility: Journal of the British Fertility Society

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https://www.readbyqxmd.com/read/28523980/diverse-endometrial-mrna-signatures-during-the-window-of-implantation-in-patients-with-repeated-implantation-failure
#1
Cheng Shi, Hong Jing Han, Li Juan Fan, Jing Guan, Xing Bang Zheng, Xi Chen, Rong Liang, Xiao Wei Zhang, Kun Kun Sun, Qing Hua Cui, Huan Shen
High endometrial receptivity in the window of implantation (WOI) is essential for successful implantation. However, a diagnostic tool with high specificity for impaired endometrial receptivity remains to be developed. We collected endometrium specimens during the WOI from patients with RIF and women who conceived after one IVF/ICSI attempt. We conducted mRNA microarray on the samples followed by relevant comparative and functional analysis. Microarray analysis revealed 357 dysregulated mRNAs between the two groups...
May 19, 2017: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/28523952/is-male-factor-infertility-associated-with-midlife-low-grade-inflammation-a-population-based-study
#2
Katia Keglberg Hærvig, Lene Kierkegaard, Rikke Lund, Helle Bruunsgaard, Merete Osler, Lone Schmidt
Male factor infertility is associated with an increased risk of disease and mortality, which has been related to markers of chronic systemic inflammation. The objective of this study was to investigate the association between male factor infertility and low-grade inflammation and furthermore to examine the lifetime prevalence of male factor infertility and overall infertility (also including female and couple infertility). The study population consisted of 2140 members of the Metropolit 1953 Danish Male Birth Cohort who had participated in the Copenhagen Aging and Midlife Biobank data collection in 2009-2011...
May 19, 2017: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/28521575/high-frequency-of-de-novo-daz-microdeletion-in-sperm-nuclei-of-subfertile-men-possible-involvement-of-genome-instability-in-idiopathic-male-infertility
#3
Hossein Mozdarani, Pegah Ghoraeian, Sohail Mozdarani, Parvin Fallahi, Anahita Mohseni-Meybodi
The occurrence and diagnosis of Y-chromosome microdeletions, specifically deletions of the DAZ (Deleted in Azoospermia) genes are an important issue in male infertility. Screening Y chromosome microdeletion is mainly done using polymerase chain reaction (PCR) on blood leukocytes. However, there is some evidence indicating that presence of DAZ in somatic cells might not be indicative of its presence in the germ cell lineage. Therefore, a total of 130 men with poor semen quality were examined for presence of DAZ microdeletion in their leukocytes...
May 19, 2017: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/28521566/quality-of-life-in-turkish-infertile-couples-and-related-factors
#4
Asli Goker, Emre Yanikkerem, Ozer Birge, Naci Kemal Kuscu
Infertility is a major life crisis affecting couples' psychosocial and physical health. We aimed to assess the quality of life in Turkish infertile couples. This cross-sectional survey was carried out in 127 infertile couples admitted to a University Hospital. The quality of life was measured using the fertility quality of life tool (FertiQoL) scale. Women had lower overall quality of life than men. Women and men who were married for fewer than 10 years had a significantly lower emotional score. Women who had a history of infertility treatment, men who have lived in the town or village men with primary infertility and men who have had primary education or lower, had lower scores for mind/body subscale...
May 19, 2017: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/28460579/management-of-weight-loss-in-obesity-associated-male-infertility-a-spotlight-on-bariatric-surgery
#5
Firass Abiad, Johnny Awwad, Hussein A Abbas, Dina Zebian, Ghina Ghazeeri
In recent years, there has been a paralleled increase between male obesity and infertility rates. Obesity is associated with impaired hypothalamic-pituitary-gonadal axis, aberrant semen parameters, and subfertility or infertility. Weight loss is strongly recommended for the management of obesity-associated infertility. Lifestyle modifications that include caloric restriction and increased physical activity have a short-lived impact. Bariatric surgery is a better and more durable weight loss alternative. Comprehensive information about the benefits of weight loss on obesity-associated male infertility following bariatric surgery is still emerging...
May 2, 2017: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/28449623/why-search-for-a-sperm-donor-online-the-experiences-of-women-searching-for-and-contacting-sperm-donors-on-the-internet
#6
Vasanti Jadva, Tabitha Freeman, Erika Tranfield, Susan Golombok
Whilst studies have examined the experiences of women who use clinic donors, to date there has been limited research investigating women's motivations and experiences of searching for a sperm donor online. A total of 429 women looking for a sperm donor on Pride Angel (a website that facilitates contact between donors and recipients) completed an online survey. Fifty-eight percent (249) saw advantages of obtaining donated sperm online with the most common advantage reported as being able to connect with and meet the donor (n = 50 (24%))...
April 28, 2017: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/28446046/use-of-embryo-culture-supernatant-to-improve-clinical-outcomes-in-assisted-reproductive-technology-a-systematic-review-and-meta-analysis
#7
Mohan Shashikant Kamath, Mariano Mascarenhas, Richard Kirubakaran, Raju Nair, Abhijit Kulkarni
We planned a systematic review and meta-analysis of randomized clinical trials (RCTs) to examine the best available evidence regarding the intrauterine instillation of embryo culture supernatant prior to embryo transfer in ART. The outcomes were: (i) live birth; (ii) clinical pregnancy; (iii) multiple pregnancy; and (iv) miscarriage rates. Five RCTs were considered eligible and available for qualitative synthesis. Due to clinical heterogeneity, results from only two trials were combined for the meta-analysis...
April 26, 2017: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/28438071/time-to-re-evaluate-art-protocols-in-the-light-of-advances-in-knowledge-about-methylation-and-epigenetics-an-opinion-paper
#8
Yves Menezo, Brian Dale, Kay Elder
DNA methylation is a biochemical process that modifies gene expression without changing the underlying DNA sequence, and this represents the molecular basis for imprinting and epigenetics. Recent reports have revealed alterations in DNA methylation profiles in the placenta of babies born from assisted reproductive technologies (ART). This supports several previous observations that suggested an increase in the prevalence of imprinting diseases following ART treatment, and also fits our observations regarding the metabolism and requirements of early human embryos...
April 25, 2017: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/28421850/semen-parameters-and-pregnancy-rates-after-microsurgical-varicocelectomy-in-primary-versus-secondary-infertile-men
#9
Essam-Elden Mohamed, Mahwer Gawish, Aly Mohamed
In a prospective study, the outcomes of microsurgical varicocelectomy in men with primary versus secondary infertility were compared. Ninety-two infertile men with a varicocele were included. They were classified into those with primary infertility (n = 57) and secondary infertility (n = 35). Clinical data, semen parameters and scrotal ultrasound finding were available for all patients and microsurgical varicocelectomy was performed on all of them. Spontaneous pregnancy rates and improvement in semen parameters in those men with primary versus secondary infertility were recorded 1 year after surgery...
April 19, 2017: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/28355952/is-there-evidence-to-support-serum-antinuclear-antibodies-testing-in-women-with-recurrent-implantation-failure-undergoing-in-vitro-fertilization
#10
Yuuki Charlie Barke Na, Sonia Asif, Nicholas J Raine-Fenning
One of the most challenging aspects of reproductive medicine is the management of recurrent implantation failure. Various investigations, including antinuclear antibodies testing, are performed to seek an explanation and guide treatment. However, is there sufficient evidence or available therapeutic options to support antinuclear antibodies testing? We present a short review on the current literature and an attempt at a systematic review evaluating the association between antinuclear antibodies and recurrent implantation failure to address this question...
March 30, 2017: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/28330414/male-subfertility-as-a-chronic-illness-the-role-of-adaptive-challenges
#11
Eleanor L Stevenson, Kevin R McEleny
Male factor infertility (MFI) is extremely common, often with several associated chronic health conditions. Because a man's fertility assessment may be their first contact with health services, the health care team has a responsibility to act as male health advocates to ensure comprehensive care. The diagnosis of subfertility allows a broader view of these men as patients with a chronic illness who have complex health needs. Because of the associated complexity of care following evaluation, there needs to be new approach in how men affected by MFI should be managed long term...
March 22, 2017: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/28325095/concomitant-use-of-fsh-and-low-dose-recombinant-hcg-during-the-late-follicular-phase-versus-conventional-controlled-ovarian-stimulation-for-intracytoplasmic-sperm-injection-cycles
#12
Carla Andrade Rebello Iaconelli, Amanda Souza Setti, Daniela Paes Almeida Ferreira Braga, Luiz Guilherme Louzada Maldonado, Assumpto Iaconelli, Edson Borges, Tsutomu Aoki
The objective of this study was to investigate the effects of low-dose hCG supplementation on ICSI outcomes and controlled ovarian stimulation (COS) cost. Three hundred and thirty patients undergoing ICSI were split into groups according to the COS protocol: (i) control group (n = 178), including patients undergoing conventional COS treatment; and (ii) low-dose hCG group (n = 152), including patients undergoing COS with low-dose hCG supplementation. Lower mean total doses of FSH administered and higher mean oestradiol level and mature oocyte rates were observed in the low-dose hCG group...
March 22, 2017: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/28270024/human-mthfr-g1793a-transition-may-be-a-protective-mutation-against-male-infertility-a-genetic-association-study-and-in-silico-analysis
#13
Mohammad Karimian, Abasalt Hosseinzadeh Colagar
In this paper, we evaluate the association of the human methylenetetrahydrofolate reductase (MTHFR)-G1793A transition with male infertility using a case-control study, a meta-analysis and an in silico analysis. In the case-control study, 308 blood samples (169 infertile and 139 fertile men) were collected. MTHFR-G1793A genotyping was performed by PCR-RFLP. The study revealed a significant protective association between the GA genotype (OR: 0.3737, 95%CI: 0.1874-0.7452, p = 0.0052) and A allele (OR: 0.4266, 95%CI: 0...
March 7, 2017: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/28447891/the-40th-meeting-of-the-editorial-board
#14
Allan A Pacey
No abstract text is available yet for this article.
June 2017: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/28256183/british-fertility-society
#15
(no author information available yet)
No abstract text is available yet for this article.
April 2017: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/28256182/volume-20-a-major-landmark
#16
Allan A Pacey
No abstract text is available yet for this article.
April 2017: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/28118765/lines
#17
Jacqui O'kane
I wrote this poem while marveling at the birth of my now 4-year-old daughter. My husband Stephen and I had tried to conceive for several months, and we were overjoyed when Sophie finally arrived. Embarking on the fertility journey again - this time with deeper awareness of my own subfertility - I reflect anew on the treasures and travails of pregnancy. Specifically, I have noticed that my greatest hopes hinge on the most miniscule lines of a home pregnancy test. That such small lines could subsume sublime significance is a wonder to me...
April 2017: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/27846734/reproductive-technologies-and-the-risk-of-congenital-heart-defects
#18
Satoru Iwashima, Takamichi Ishikawa, Hiroaki Itoh
Assisted reproductive technology (ART) has become widespread, accounting for ∼2% of all births worldwide, with a similar proportion in Japan. Our goal was to determine whether ART is associated with an increased risk of congenital heart defect (CHD). The study subjects were 2716 pregnant women (2317 in a spontaneous conception [SC] group and 399 in an assisted conception [AC] group). Of patients in the AC group, 142 were treated with ovulation-inducing agents (OIAs), 56 with artificial insemination by the husband (AIH), 159 with in vitro fertilization (IVF), and 42 with intracytoplasmic sperm injection (ICSI)...
April 2017: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/27844488/how-do-laboratory-embryo-transfer-techniques-affect-ivf-outcomes-a-review-of-current-literature
#19
George Sigalos, Olga Triantafyllidou, Nikos Vlahos
Over the last few years, many studies have focused on embryo selection methods, whereas little attention has been given to the standardization of the procedure of embryo transfer. In this review, several parameters of the embryo transfer procedure are examined, such as the: (i) culture medium volume and loading technique; (ii) syringe and catheters used for embryo transfer; (iii) viscosity and composition of the embryo transfer medium; (iv) environment of embryo culture; (v) timing of embryo transfer; (vi) and standardization of the embryo transfer techniques...
April 2017: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/27841038/experiences-of-faith-group-members-using-new-reproductive-and-genetic-technologies-a-qualitative-interview-study
#20
Jackie Leach Scully, Sarah Banks, Robert Song, Jackie Haq
This paper explores the experiences of members of faith groups deciding whether or not to use new reproductive or genetic technologies (NRGTs). It is based on 16 in-depth, semi-structured interviews with people with direct experience of NRGTs. Participants identified as members of Christian or Muslim faith traditions and had been faced with deciding whether or not to make use of novel forms of fertility treatment or genetic testing. The findings show that members of faith groups may experience specific barriers of access, and distinctive ethical difficulties, when considering the use of different forms of NRGTs...
April 2017: Human Fertility: Journal of the British Fertility Society
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