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Human Fertility: Journal of the British Fertility Society

Vasanti Jadva, Helen Prosser, Natalie Gamble
This study aimed to explore UK intending parent's reasons for cross-border and domestic surrogacy, their preparations for the birth and the practical and legal challenges faced after the birth. An online survey was completed by 203 participants, of which 132 had a child born through surrogacy, 33 were in the process of surrogacy and 38 were planning a surrogacy arrangement. The most common reason for pursuing surrogacy in the UK was wanting a relationship with the surrogate (43%; n = 17) and for conducting surrogacy in the USA was because of a better legal framework (97%; n = 60)...
December 11, 2018: Human Fertility: Journal of the British Fertility Society
Jung A Kim, Cho Hee Bang, Gwan Gyu Song, Jae-Hoon Kim, Sung Jae Choi, Jae Hyun Jung
Tumour necrosis factor alpha (TNF-α) concentration is associated with recurrent pregnancy loss (RPL). Moreover, TNF-α promoter polymorphisms affect cellular TNF-α concentrations. Although several studies on TNF-α polymorphisms have been reported, these studies only define specific loci and result in conflicting conclusions. The meta-analysis in this study was performed to examine the relationship between various TNF-α polymorphisms and RPL. We searched for articles, using MEDLINE and Embase, and performed meta-analysis of 21 studies involving 3437 cases and 4016 controls...
December 2, 2018: Human Fertility: Journal of the British Fertility Society
Jing Xie, Lailai Yan, Zixi Cheng, Lijuan Qiang, Jingjing Yan, Yingying Liu, Rong Liang, Jingxu Zhang, Zhiwen Li, Lili Zhuang, Cuifang Hao, Bin Wang, Qun Lu
This study investigated the association between inflammation in infertile women and the risk of IVF-ET failure, as well as the potential effects of various lifestyles on this association. A total of 84 women undergoing IVF-ET in Beijing China were recruited, including 38 women who did not achieve pregnancy after undergoing IVF-ET and 46 women who conceived. Serum samples were collected on the second day of menstruation before the treatment cycle and the inflammatory cytokines (interleukin-1β, interleukin-6, interleukin-8 (IL-8) and monocyte chemotactic protein-1 (MCP-1)) were measured...
November 27, 2018: Human Fertility: Journal of the British Fertility Society
Mahnaz Heidari, Sara Darbani, Mahsa Darbandi, Niknam Lakpour, Zohreh Fathi, Amir Hasan Zarnani, Hodjat Zeraati, Mohammad Mehdi Akhondi, Mohammad Reza Sadeghi
Selection of the best sperm, with the least defects, is a critical factor in the success of ART especially in male factor infertility. This study assessed the potential Heat shock protein (HSPA2) and metallopeptidase domain2 (ADAM2) biomarkers for sperm selection. Sperm were obtained from 72 asthenoteratozoospermic and 42 normospermic ejaculates. The semen characteristic, DNA fragmentation (DFI), chromatin maturation index (CMI), ADAM2 and HSPA2 levels on sperm, and their correlation with embryo quality were assessed in both groups...
November 22, 2018: Human Fertility: Journal of the British Fertility Society
Ákos Várnagy, Tamás Kőszegi, Erzséber Györgyi, Sarolta Szegedi, Endre Sulyok, Viktória Prémusz, József Bódis
This study was designed to evaluate the levels of oxidative stress (OS) markers, total non-enzymatic antioxidant capacity (TAC) and 8-hydroxy-2'-deoxyguanosine (8-OHdG) in the serum and follicular fluid (FF) of patients undergoing in vitro fertilization (IVF). The impact of these biomarkers on IVF outcome was also analysed. Samples were obtained from 61 patients (age: 36.40 ± 4.99 years; BMI: 22.54 ± 2.46; infertility: 3.7 ± 2.5 years [mean ± SD]) before and after controlled ovarian hyperstimulation (COH)...
November 13, 2018: Human Fertility: Journal of the British Fertility Society
Heather Garthwaite, Jane Stewart, Kathryn King, Ken McGarry, Scott Wilkes
The National Institute for Health and Care Excellence Clinical Guideline 156 advises that transvaginal ultrasonography (TVUS) should be used in the first cycle of treatment with clomifene citrate, to assess for multifollicular development and hence the risk of multiple pregnancy. This guidance is based on expert opinion rather than research evidence. We conducted a cross-sectional online and postal survey among UK-based consultant gynaecologists and fertility specialists, to explore compliance with this guideline...
November 2, 2018: Human Fertility: Journal of the British Fertility Society
Astrid Indekeu, Claudia Lampic
Disclosure issues in relation to donor conception have mainly been examined in the context of relationships and interaction within donor-conceived families, whilst influences from outside the family, for example societal ones, have been little researched. This study explored the societal experiences of individuals who build their family with the help of donor conception (i.e. donor-conceived families), specifically, where and how parents and society interact and the presence and influence of cultural beliefs and values regarding the family...
November 2, 2018: Human Fertility: Journal of the British Fertility Society
Kylie Baldwin, Lorraine Culley
Very few studies have explored women's experiences of social egg freezing and the limited primary research on this topic has suggested that users find the process of freezing eggs emotionally challenging. We, therefore, undertook semi-structured interviews with 31 women who identified as undergoing egg freezing for social reasons in order to explore how female users of social egg freezing technology reported their experience of freezing eggs for 'social' reasons. Interviews lasted between 40 minutes and 2 hours, were audio recorded and transcribed verbatim...
November 1, 2018: Human Fertility: Journal of the British Fertility Society
Mahrukh Hameed Zargar, Syed Shafia, Shariq Rashid Masoodi, Qurteeba Mahajan, Nabeela Khan, Rehana Ahmad
Inhibin is a glycoprotein produced by granulosa cells and its main function is the negative feedback control of follicle stimulating hormone (FSH) which has an important role in folliculogenesis. Mutation in the INHα gene leading to decreased bioactive inhibin has been associated with primary ovarian insufficiency (POI). The aim of this study was to investigate the role of variations in the INHα gene in increasing the susceptibility to POI in Kashmiri women. INHα c.769G > A mutation was analysed in 100 POI cases and 100 controls using PCR-RFLP and agarose gel electrophoresis...
October 19, 2018: Human Fertility: Journal of the British Fertility Society
Azahara Turienzo, Belén Lledó, José A Ortiz, Ruth Morales, Juan Sanz, Joaquín Llácer, Rafael Bernabeu
Recurrent pregnancy loss (RPL; defined as the loss of three or more consecutive pregnancies) and recurrent implantation failure (RIF; when implantation is not achieved after at least three cycles of IVF) are two of the major challenges that reproductive medicine faces. Some polymorphisms have been identified as possible causes of an increased risk of these diseases. This paper studies the prevalence of the polymorphisms in p53, VEGF, IL-10, IL-11 and APOE in RIF and RPL patients that determines the risk for these pathologies...
October 18, 2018: Human Fertility: Journal of the British Fertility Society
Manouk Hendrix, Jolijn Arits, Roy Bannink, Aafke van Montfoort, Christine Willekes, Janneke den Hartog, Salwan Al-Nasiry
The aim of this study was to test whether women who conceived after a period of subfertility are less likely to undergo invasive prenatal testing (IPT) and determine factors of influence in that decision. We conducted a retrospective study at the Maastricht University Medical Centre (MUMC+) to compare the rates of IPT following abnormal results of combined first trimester screening (cFTS) or second trimester screening (STS), or because of advanced maternal age among women tested for the effect of type and duration of subfertility and history of fertility investigations and/or treatment...
September 28, 2018: Human Fertility: Journal of the British Fertility Society
Sara Mesquita da Silva, Jean Marie Place, Jacky Boivin, Sofia Gameiro
Biological parenthood is a central life-goal for many couples that can become blocked when they experience infertility. Many couples who undergo fertility treatment will face failure and consequently have to decide whether to continue with treatment. The present study used the qualitative methodology of Interpretative Phenomenological Analysis to examine self-regulatory approaches that underlie decision-making about continuing treatment. One-time, one-on-one, semi-structured, in-depth interviews were conducted with 16 individuals (eight heterosexual couples) after they had experienced at least one treatment failure and were considering whether to undergo another treatment...
September 26, 2018: Human Fertility: Journal of the British Fertility Society
Anne Marie de Man, Alexandra Rashedi, Willianne Nelen, Antoinette Anazodo, Alfred Rademaker, Saskia de Roo, Catharina Beerendonk, Teresa Woodruff
As cancer survival rates continue to increase, so does the relevance of starting or expanding a family after cancer, impacting quality of life. However, the option of fertility preservation is not always addressed by physicians before treatment. In the meanwhile, many patients look for health information online. Although potentially helpful in the decision-making process, the Internet could also have adverse effects for this vulnerable patient group when information is incorrect. We aimed to assess the availability and quality of information on female oncofertility on websites of (inter)national oncology, fertility and oncofertility organizations...
September 19, 2018: Human Fertility: Journal of the British Fertility Society
Allan A Pacey
No abstract text is available yet for this article.
December 2018: Human Fertility: Journal of the British Fertility Society
Emily C Holden, Laura E Dodge, Rita Sneeringer, Vasiliki A Moragianni, Alan S Penzias, Michele R Hacker
Our objective was to determine if a correlation exists between endometrial thickness measured on the day of ovulation trigger during an in vitro fertilization (IVF) cycle and pregnancy outcomes among non-cancelled cycles. We performed a retrospective cohort study looking at 6331 women undergoing their first, fresh autologous IVF cycle from 1 May 2004 to 31 December 2012 at Boston IVF (Waltham, MA). Our primary outcome was the risk ratio (RR) of live birth and positive β-hCG. We found that thicker endometrial linings were associated with positive β-hCG and live birth rates...
December 2018: Human Fertility: Journal of the British Fertility Society
Rana Ghandehari-Alavijeh, Dina Zohrabi, Marziyeh Tavalaee, Mohammad Hossein Nasr-Esfahani
Reduced sperm motility (asthenozoospermia) accounts for a significant percentage of male infertility and numerous factors have been suggested to explain this phenomenon among which hypoxic and inflammatory markers are the least studied. Therefore, the aim of this study was to assess the main molecular markers involved in hypoxia (P53 and HIF-1α) and inflammation (TNF-α) pathways in infertile men with asthenozoospermia. Expression of these markers were assessed by qRT-PCR, and analysis of data show that mean of hypoxia markers (P53, HIF-1α) and also TNF- α were significantly higher in infertile men with asthenozoospermia compared to fertile men (p < 0...
September 17, 2018: Human Fertility: Journal of the British Fertility Society
David Crosby, Yvonne O'Brien, Louise Glover, Fiona Martyn, Mary Wingfield
To date there is limited published data assessing whether body mass index (BMI) influences endometrial thickness (ET) and whether this impacts on pregnancy outcomes in single blastocyst FET cycles. The objective of this study, therefore, was to examine the relationship between BMI and ET on the outcome of single blastocyst FET cycles over a five-year period from 2012 until 2016. Patient age, BMI, endometrial pattern and ET prior to FET were recorded. Pregnancy outcomes included: implantation rate, clinical pregnancy rate and live birth rate...
September 17, 2018: Human Fertility: Journal of the British Fertility Society
Jelena Djurovic, Gorana Stamenkovic, Jelena Todorovic, Natasa Aleksic, Oliver Stojkovic
Unexplained infertility refers to the absence of a definable cause of reproductive failure. Vitamin D receptor (VDR) acts as a transcription factor and regulates a number of vitamin D-responsive genes, including those involved in the immune system. Recent finding that VDR is expressed in reproductive tissues suggests a possible importance of vitamin D in pregnancy. We conducted a case-control study to examine the association of polymorphisms in VDR gene with reproductive success. DNA from 117 female patients with unexplained infertility and 130 fertile controls was isolated from peripheral blood and VDR genotypes (FokI, BsmI, ApaI and TaqI) were detected by PCR-RFLP...
September 17, 2018: Human Fertility: Journal of the British Fertility Society
Zohreh Heidary, Kioomars Saliminejad, Majid Zaki-Dizaji, Hamid Reza Khorram Khorshid
Infertility is a worldwide problem affecting about 15% of couples trying to conceive. Asthenozoospermia (AZS) is one of the major causes of male infertility, diagnosed by reduced sperm motility, and has no effective therapeutic treatment. To date, a few genes have been found to be associated with AZS in humans and mice, but in most of cases its molecular aetiology remains unknown. Genetic causes of AZS may include chromosomal abnormalities, specific mutations of nuclear and mitochondrial genes. However recently, epigenetic factors, altered microRNAs expression signature, and proteomics have shed light on the pathophysiological basis of AZS...
September 9, 2018: Human Fertility: Journal of the British Fertility Society
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