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Human Fertility: Journal of the British Fertility Society

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https://www.readbyqxmd.com/read/29793356/ongoing-pregnancies-in-patients-with-unexplained-recurrent-pregnancy-loss-adverse-obstetric-outcomes
#1
Mauro Cozzolino, Francesca Rizzello, Chiara Riviello, Chiara Romanelli, Maria Coccia Elisabetta
To investigate the incidence of adverse pregnancy outcomes in couples with an unexplained Recurrent Pregnancy Loss (RPL) history, a retrospective cohort study was conducted between 2014 and 2015. The study group (A) included couples with an unexplained RPL, and the control group (B) was composed of couples who attended the Low-Risk Antenatal Unit during the same period. On the other hand, 53 couples were included in the study group (A) and on the other hand, 65 in the control group (B). Women with previous unexplained recurrent pregnancies loss had a significantly increased risk of gestational diabetes with 12 cases (22...
May 25, 2018: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/29781316/fas-and-fasl-genetic-polymorphisms-in-women-with-recurrent-pregnancy-loss-a-case-control-study
#2
Ae Ra Han, Young Min Choi, Min A Hong, Jin Ju Kim, Sung Ki Lee, Kwang Moon Yang, Eun Chan Paik, Hyeon Jeong Jeong, Jong Kwan Jun
Aberrant apoptosis at the trophoblast-maternal interface and abnormal expression of Fas and Fas ligand (FasL) have been reported in complicated pregnancies with recurrent pregnancy losses (RPL) and preeclampsia. We assessed the prevalence of Fas and FasL genetic polymorphisms in Korean women with RPL and in fertile controls. In total, 306 women with RPL and 298 fertile controls were enrolled. Genotype distributions of Fas and FasL in RPL patients versus fertile controls were examined under the Hardy-Weinberg equilibrium...
May 20, 2018: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/29768933/psychiatric-disorders-in-women-and-men-up-to-five-years-after-undergoing-assisted-reproductive-technology-treatment-a-prospective-cohort-study
#3
Helena Volgsten, Lone Schmidt, Agneta Skoog Svanberg, Lisa Ekselius, Inger Sundström Poromaa
This is a prospective cohort study with the objective to describe psychiatric disorders, such as any mood and anxiety disorders, in both women and men five years after assisted reproductive technology (ART). The Primary Care Evaluation of Mental Disorders (PRIME-MD) questionnaire, based on the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV), was used as the diagnostic tool to evaluate psychiatric disorders. Logistic regression analysis was used to calculate odds ratios (ORs) and confidence interval (CI) for factors associated with psychiatric disorders at the follow-up...
May 17, 2018: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/29749276/cryopreservation-of-low-number-of-human-spermatozoa-which-is-better-vapor-phase-or-direct-submerging-in-liquid-nitrogen
#4
Akram Hosseini, Mohammad Ali Khalili, Ali Reza Talebi, Azam Agha-Rahimi, Saeed Ghasemi-Esmailabad, Bryan Woodward, Nahid Yari
Cryopreservation and subsequent survival of semen samples with low numbers of human spermatozoa in assisted reproductive technology (ART) facilities can be challenging. The aim of this study was to compare the quality of warmed human spermatozoa following vitrification using direct submerging (DS) in liquid nitrogen (LN2 ) or with LN2 vapour (V). Normozoospermic ejaculates were prepared by the swim-up technique and the motile sperm fraction was divided into three groups: (i) fresh (control); (ii) DS methods in LN2 (DS Group); or (iii) cryopreserved in V (Group V)...
May 11, 2018: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/29745280/reporting-on-longitudinal-live-birth-rates-and-cumulative-delivery-rates-are-more-realistic-outcome-measures-than-sperm-retrieval-rates-in-couples-undergoing-mtese-icsi
#5
Khaled Almekaty, Saad Abomelha, Yau Thum, James Nicopoullos, Tim Bracewell-Milnes, Tet Yap, Suks Minhas
The live birth rates (LBRs) in men with non-obstructive azoospermia (NOA) undergoing microdissection TESE (mTESE) are under reported, with surgical sperm retrieval rate often used as the primary outcome measure. We analysed longitudinal and cumulative delivery rates following mTESE- intracytoplasmic sperm injection (ICSI) in NOA. Sperm was retrieved in 45% of patients undergoing mTESE. Median male and female age were 42 years (IQR 37-47) and 35 years (IQR 31-38) respectively. A total of 141 ICSI cycles and 23 frozen embryo transfers resulted in 62 pregnancies and 37 LBRs...
May 10, 2018: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/29720000/a-comparison-of-the-survival-and-implantation-rates-of-blastocysts-that-were-vitrified-on-post-fertilization-day-five-six-and-seven
#6
Avci Berrin, Kasapoglu Isıl, Ata Baris, Kuspinar Goktan, Saribal Seda, Uncu Gurkan
The goal of this retrospective cohort study was to compare survival, implantation, clinical and ongoing pregnancy rates between blastocysts that were vitrified on post-fertilization days 5, 6 and 7. Before vitrification, blastocysts were evaluated in terms of morphology and blastocyst expansion, inner cell mass and trophectoderm quality. They were thawed and transfered in a subsequent artificial cycle. Embryo implantation rates were 39%, 25% and 25% for blastocysts that were vitrified on days 5, 6, and 7, respectively (p = 0...
May 3, 2018: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/29701081/human-charcoal-stripped-serum-supplementation-enhances-both-the-stearoyl-coenzyme-a-desaturase-1-activity-of-cumulus-cells-and-the-in-vitro-maturation-of-oocytes
#7
Alireza Mardomi, Mohammad Nouri, Laya Farzadi, Nosratollah Zarghami, Amir Mehdizadeh, Mehdi Yousefi, Dariush Shanebandi, Maghsod Shaaker, Masoud Darabi
Obtaining a better outcome in assisted reproductive technology remains to be attained. In the case of in vitro fertilization (IVF), oocyte maturity is paramount for achieving a successful pregnancy. Maternal serum supplementation of in vitro maturation (IVM) medium can increase the rate of oocyte IVM. The aim of the present study was to compare the effect of whole and charcoal-stripped serum supplementation on IVM and the activity index of stearoyl-coenzyme A desaturase 1 (SCD1) in cumulus cells enclosing the oocyte as a molecular indicator of oocyte quality...
April 27, 2018: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/29688091/molecular-detection-of-hhv1-5-aav-and-hpv-in-semen-specimens-and-their-impact-on-male-fertility
#8
Emad Behboudi, Talat Mokhtari-Azad, Jila Yavarian, Nastaran Ghavami, Seyed Mahmood Seyed Khorrami, Farhad Rezaei, Javad Charostad, Somayeh Shatizadeh Malekshahi, Nazanin Zahra Shafiei-Jandaghi
Viral infections have been considered as possible destructive factors that influence male fertility. The aim of this study was to determine the prevalence of human herpes viruses 1-5 (HHV1-5), adeno associated virus (AAV) and human papilloma virus (HPV) in semen and whether these influence semen quality. DNA extraction was performed using phenol-chloroform protocol, then three different nested-PCRs were done to detect HHV1-5, AAV and HPV DNAs in the semen samples. Of 145 samples, 66 (45.5%) were positive at least for one of the viruses...
April 24, 2018: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/29671650/early-outcomes-of-a-municipally-funded-oocyte-cryopreservation-programme-in-japan
#9
Iwaho Kikuchi, Noriko Kagawa, Yuka Shirosaki, Ikumi Shinozaki, Yasuka Miyakuni, Kyoko Oshina, Michio Nojima, Koyo Yoshida
One factor explaining the declining birth rate in Japan is the social advancement of women. Women are delaying marriage and childbirth, with many then facing so-called 'social infertility'. Advanced infertility treatment options, such as in vitro fertilization, are available, but the costs are high. Further, the success rates for 'older' women are only around 10%. We report the preliminary results of an oocyte cryopreservation programme promoted and subsidized by our city government. Citywide seminars were conducted to generate awareness of issues surrounding fertility...
April 19, 2018: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/29671648/non-commercial-surrogacy-among-close-relatives-in-vietnam-policy-and-ethical-implications
#10
Yuri Hibino
Altruistic surrogacy among close relatives has been legal in Vietnam since the beginning of 2015. Following the revision of the Marriage and Family Law, there have been dozens of cases of surrogacy, and instances of successful pregnancy and childbirth have also been reported. Although surrogacy was completely prohibited in 2003, numerous local brokers offered commercial surrogacy services. Today, surrogacy is permitted under very limited conditions, and commercial surrogacy is prohibited. However, brokers continue to offer illegal commercial surrogacy services, and some even present its incidence may be increasing...
April 19, 2018: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/29609488/telomeres-as-a-molecular-marker-of-male-infertility
#11
Ewa Boniewska-Bernacka, Anna Pańczyszyn, Natalia Cybulska
In recent years, male infertility has become a growing social problem. Standard diagnostic procedures, based on assessing seminological parameters, are often insufficient to explain the causes of male infertility. Because of this, new markers with better clinical application are being sought. One of the promising markers seems to be an assessment of telomere length of sperm. Sperm telomeres, in contrast to somatic cells, are elongated as men age. The results of some studies suggest that telomere length may be relevant in the case of fertilization and normal embryo development...
April 2, 2018: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/29683395/ivf-s-40th-birthday
#12
Allan A Pacey
No abstract text is available yet for this article.
June 2018: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/28975815/office-hysteroscopic-guided-selective-tubal-chromopertubation-acceptability-feasibility-and-diagnostic-accuracy-of-this-new-diagnostic-non-invasive-technique-in-infertile-women
#13
Gaspare Carta, Patrizia Palermo, Chiara Pasquale, Valeria Conte, Ruggero Pulcinella, Stefano Necozione, Vincenza Cofini, Felice Patacchiola
The aim of this study was to evaluate accuracy, tolerability and side effects of office hysteroscopic-guided chromoperturbations in infertile women without anaesthesia. Forty-nine infertile women underwent the procedure to evaluate tubal patency and the uterine cavity. Women with unilateral or bilateral tubal stenosis at hysteroscopy with chromoperturbation, and women with bilateral tubal patency who did not conceive during the period of six months, underwent laparoscopy with chromoperturbation. The results obtained from hysteroscopy and laparoscopy in the assessment of tubal patency were compared...
June 2018: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/28881151/jean-marian-purdy-remembered-the-hidden-life-of-an-ivf-pioneer
#14
Roger Gosden
Jean Purdy is almost forgotten as one of the British trio that introduced clinical IVF to the world. An unlikely pioneer, she qualified as a nurse but through indefatigable effort and unstinting loyalty to a programme that faced vitriolic opposition she became the clinical embryologist for the first IVF baby. In 1980, she helped to launch fertility services as the 'Technical Director' of Bourn Hall Clinic, near Cambridge. Although Robert Edwards and Patrick Steptoe generously credited her role in research and clinical care, a premature death in 1985 at age 39 robbed her of the reward of witnessing the blossoming of assisted reproductive technologies for patients around the world...
June 2018: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/28602104/reproductive-outcome-following-pre-implantation-genetic-diagnosis-pgd-in-the-uk
#15
Abigail Sharpe, Peter Avery, Meenakshi Choudhary
In 2013, the National Health Service Commissioning board centralized the funding in England for up to three cycles of pre-implantation genetic diagnosis (PGD) for couples who have, or are carriers of, a specific genetic disorder. This study presents the historical data of PGD cycles and their clinical outcomes in UK as extrapolated from the national data registry. Retrospective analysis of outcome of cycles undergoing pre-implantation genetic diagnosis in the UK over the past 20 years was performed from the Human Fertilisation and Embryology Authority database (n = 2974)...
June 2018: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/28554223/outpatient-management-of-severe-ovarian-hyperstimulation-syndrome-a-systematic-review-and-a-review-of-existing-guidelines
#16
Amr Gebril, Haitham Hamoda, Raj Mathur
Ovarian hyperstimulation syndrome (OHSS) is a potentially serious complication of assisted reproductive treatment. Management of women with severe OHSS has traditionally included hospitalisation for close monitoring and supportive treatment. The aim of this review is to assess the evidence for safety and efficacy of outpatient management of severe OHSS. A systematic review of studies describing outpatient management options was performed. Current guidance from advisory bodies was also reviewed. Outpatient management has been found in observational studies to be safe and cost-effective compared to inpatient management...
June 2018: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/28523952/is-male-factor-infertility-associated-with-midlife-low-grade-inflammation-a-population-based-study
#17
Katia Keglberg Hærvig, Lene Kierkegaard, Rikke Lund, Helle Bruunsgaard, Merete Osler, Lone Schmidt
Male factor infertility is associated with an increased risk of disease and mortality, which has been related to markers of chronic systemic inflammation. The objective of this study was to investigate the association between male factor infertility and low-grade inflammation and furthermore to examine the lifetime prevalence of male factor infertility and overall infertility (also including female and couple infertility). The study population consisted of 2140 members of the Metropolit 1953 Danish Male Birth Cohort who had participated in the Copenhagen Aging and Midlife Biobank data collection in 2009-2011...
June 2018: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/28521575/high-frequency-of-de-novo-daz-microdeletion-in-sperm-nuclei-of-subfertile-men-possible-involvement-of-genome-instability-in-idiopathic-male-infertility
#18
Hossein Mozdarani, Pegah Ghoraeian, Sohail Mozdarani, Parvin Fallahi, Anahita Mohseni-Meybodi
The occurrence and diagnosis of Y-chromosome microdeletions, specifically deletions of the DAZ (Deleted in Azoospermia) genes are an important issue in male infertility. Screening Y chromosome microdeletion is mainly done using polymerase chain reaction (PCR) on blood leukocytes. However, there is some evidence indicating that presence of DAZ in somatic cells might not be indicative of its presence in the germ cell lineage. Therefore, a total of 130 men with poor semen quality were examined for presence of DAZ microdeletion in their leukocytes...
June 2018: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/28449623/why-search-for-a-sperm-donor-online-the-experiences-of-women-searching-for-and-contacting-sperm-donors-on-the-internet
#19
Vasanti Jadva, Tabitha Freeman, Erika Tranfield, Susan Golombok
Whilst studies have examined the experiences of women who use clinic donors, to date there has been limited research investigating women's motivations and experiences of searching for a sperm donor online. A total of 429 women looking for a sperm donor on Pride Angel (a website that facilitates contact between donors and recipients) completed an online survey. Fifty-eight percent (249) saw advantages of obtaining donated sperm online with the most common advantage reported as being able to connect with and meet the donor (n = 50 (24%))...
June 2018: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/28446046/use-of-embryo-culture-supernatant-to-improve-clinical-outcomes-in-assisted-reproductive-technology-a-systematic-review-and-meta-analysis
#20
Mohan Shashikant Kamath, Mariano Mascarenhas, Richard Kirubakaran, Raju Nair, Abhijit Kulkarni
We planned a systematic review and meta-analysis of randomized clinical trials (RCTs) to examine the best available evidence regarding the intrauterine instillation of embryo culture supernatant prior to embryo transfer in ART. The outcomes were: (i) live birth; (ii) clinical pregnancy; (iii) multiple pregnancy; and (iv) miscarriage rates. Five RCTs were considered eligible and available for qualitative synthesis. Due to clinical heterogeneity, results from only two trials were combined for the meta-analysis...
June 2018: Human Fertility: Journal of the British Fertility Society
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