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European Journal of Heart Failure

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https://www.readbyqxmd.com/read/27905161/the-impact-of-co-morbidity-burden-on-appropriate-implantable-cardioverter-defibrillator-therapy-and-all-cause-mortality-insight-from-danish-nationwide-clinical-registers
#1
Anne Christine Ruwald, Michael Vinther, Gunnar H Gislason, Jens Brock Johansen, Jens Cosedis Nielsen, Helen Høgh Petersen, Sam Riahi, Christian Jons
AIMS: In a nationwide cohort of primary (PP-ICD) and secondary prevention (SP-ICD) implantable cardioverter defibrillator (ICD) patients, we aimed to investigate the association between co-morbidity burden and risk of appropriate ICD therapy and mortality. METHODS AND RESULTS: We identified all patients >18 years, implanted with first-time PP-ICD (n = 1873) or SP-ICD (n = 2461) in Denmark from 2007 to 2012. Co-morbidity was identified in administrative registers of hospitalization and drug prescription from pharmacies...
December 1, 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27891745/cardiac-extracellular-matrix-is-associated-with-adverse-outcome-in-patients-with-chronic-heart-failure
#2
Franz Duca, Caroline Zotter-Tufaro, Andreas A Kammerlander, Adelheid Panzenböck, Stefan Aschauer, Daniel Dalos, Benedikt Köll, Benedikt Börries, Hermine Agis, Renate Kain, Klaus Aumayr, Florian Klinglmüller, Julia Mascherbauer, Diana Bonderman
AIMS: Accumulation of extracellular matrix (ECM) is known to play a crucial role in the pathophysiology of heart failure (HF). However, its prognostic relevance is poorly investigated. METHODS AND RESULTS: A total of 73 HF patients who underwent LV endomyocardial biopsy were enrolled in our study. ECM area was quantified by TissueFAXS and ImageJ software. Patients were followed-up at 6-month intervals. The study endpoint was defined as hospitalization for a cardiac reason and/or cardiac death...
November 27, 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27891719/myocardial-strain-to-detect-subtle-left-ventricular-systolic-dysfunction
#3
REVIEW
Laurens F Tops, Victoria Delgado, Nina Ajmone Marsan, Jeroen J Bax
In daily clinical practice, LV systolic function is routinely assessed with the use of two-dimensional echocardiography. Using biplane LV end-diastolic and end-systolic volumes, LVEF is calculated. The introduction of real-time three-dimensional echocardiography has improved the accuracy of echocardiographic assessment of LVEF. However, calculated LVEF may not truly represent LV systolic function in specific cardiac diseases or when subtle LV dysfunction is present. Two-dimensional speckle tracking echocardiography enables assessment of myocardial strain, thereby providing detailed information on global and regional LV deformation...
November 27, 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27878925/left-ventricular-deformation-at-rest-predicts-exercise-induced-elevation-in-pulmonary-artery-wedge-pressure-in-patients-with-unexplained-dyspnoea
#4
Tor Biering-Sørensen, Mário Santos, Jose Rivero, Shane D McCullough, Erin West, Alexander R Opotowsky, Aaron B Waxman, David M Systrom, Amil M Shah
AIMS: Impaired left ventricular (LV) deformation despite preserved LV ejection fraction (LVEF) is common and predicts outcomes in heart failure with preserved LVEF. We hypothesized that impaired LV deformation at rest is a marker of impaired cardiac systolic and diastolic reserve, and aimed to determine whether resting longitudinal (LS) and circumferential strain (CS) are associated with invasively measured haemodynamic response to exercise in patients with dyspnoea and a normal LVEF...
November 22, 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27873428/data-and-safety-monitoring-board-evaluation-and-management-of-a-renal-adverse-event-signal-in-topcat
#5
REVIEW
Michael R Bristow, Kavita Sharma, Susan F Assmann, Stuart Linas, Bernard J Gersh, Christine Grady, Madeline Murguia Rice, Steven Singh, Robin Boineau, Sonja M McKinlay, Barry H Greenberg
Clinical trial Data and Safety Monitoring Boards (DSMBs) have a primary obligation of ensuring study participant safety, while maintaining trial integrity. The role of DSMBs is expanding, and ideally should include post-hoc reporting of deliberative processes related to clinically important safety issues or factors that could impact on future trial designs. We describe how the TOPCAT DSMB detected, investigated, and adjudicated an unexpectedly large renal adverse event signal midway through the trial, and offer general guidelines for dealing with similar unanticipated occurrences in future trials...
November 21, 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27873389/sildenafil-unbridled-optimism-and-heart-failure-with-preserved-ejection-fraction
#6
EDITORIAL
Yogesh N V Reddy, Barry A Borlaug
No abstract text is available yet for this article.
November 21, 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27873388/effects-of-sildenafil-on-cardiac-structure-and-function-cardiopulmonary-exercise-testing-and-health-related-quality-of-life-measures-in-heart-failure-patients-with-preserved-ejection-fraction-and-pulmonary-hypertension
#7
Licette C Y Liu, Yoran M Hummel, Peter van der Meer, Rolf M F Berger, Kevin Damman, Dirk J van Veldhuisen, Adriaan A Voors, Elke S Hoendermis
AIMS: We recently showed that sildenafil did not improve pulmonary pressures and exercise capacity in a cohort of patients with heart failure and preserved ejection fraction (HFpEF) and predominantly postcapillary pulmonary hypertension. Here, we present the effects of sildenafil on cardiac structure and function, cardiopulmonary exercise testing, laboratory parameters and health-related quality of life measures. METHODS AND RESULTS: Fifty-two HFpEF patients with pulmonary hypertension (mean pulmonary artery pressure >25 mmHg; pulmonary artery wedge pressure >15 mmHg) were randomized to sildenafil 60 mg three times a day or placebo and treated for 12 weeks...
November 21, 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27868385/impact-of-eplerenone-on-cardiovascular-outcomes-in-heart-failure-patients-with-hypokalaemia
#8
Patrick Rossignol, Nicolas Girerd, George Bakris, Orly Vardeny, Brian Claggett, John J V McMurray, Karl Swedberg, Henry Krum, Dirk J van Veldhuisen, Harry Shi, Sean Spanyers, John Vincent, Renaud Fay, Zohra Lamiral, Scott D Solomon, Faiez Zannad, Bertram Pitt
AIMS: Although hypokalaemia is common among patients with heart failure (HF), the prognostic significance of baseline hypokalaemia and hypokalaemia during follow-up in HF patients receiving a mineralocorticoid receptor antagonist (MRA) remains uncertain. METHODS AND RESULTS: Results of the EMPHASIS-HF trial in patients (n = 2737) with HF and reduced EF with mild symptoms, randomized to eplerenone or placebo, were analysed with regard to the presence or occurrence of hypokalaemia (serum K(+) <4...
November 20, 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27868321/dementia-related-adverse-events-in-paradigm-hf-and-other-trials-in-heart-failure-with-reduced-ejection-fraction
#9
Jane A Cannon, Li Shen, Pardeep S Jhund, Søren L Kristensen, Lars Køber, Fabian Chen, Jianjian Gong, Martin P Lefkowitz, Jean L Rouleau, Victor C Shi, Karl Swedberg, Michael R Zile, Scott D Solomon, Milton Packer, John J V McMurray
AIMS: Inhibition of neprilysin, an enzyme degrading natriuretic and other vasoactive peptides, is beneficial in heart failure with reduced ejection fraction (HFrEF), as shown in PARADIGM-HF which compared the angiotensin receptor-neprilysin inhibitor (ARNI) sacubitril/valsartan with enalapril. As neprilysin is also one of many enzymes clearing amyloid-β peptides from the brain, there is a theoretical concern about the long-term effects of sacubitril/valsartan on cognition. Therefore, we have examined dementia-related adverse effects (AEs) in PARADIGM-HF and placed these findings in the context of other recently conducted HFrEF trials...
November 20, 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27860089/predictors-of-mortality-in-takotsubo-cardiomyopathy
#10
LETTER
Ibrahim El-Battrawy, Martin Borggrefe, Ibrahim Akin
No abstract text is available yet for this article.
November 17, 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27860059/right-ventricular-dysfunction-in-heart-failure-with-reduced-vs-preserved-ejection-fraction-non-identical-twins
#11
EDITORIAL
Thomas M Gorter, Michiel Rienstra, Dirk J van Veldhuisen
No abstract text is available yet for this article.
November 17, 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27860029/different-correlates-but-similar-prognostic-implications-for-right-ventricular-dysfunction-in-heart-failure-patients-with-reduced-or-preserved-ejection-fraction
#12
Stefano Ghio, Marco Guazzi, Angela Beatrice Scardovi, Catherine Klersy, Francesco Clemenza, Erberto Carluccio, Pier Luigi Temporelli, Andrea Rossi, Pompilio Faggiano, Egidio Traversi, Olga Vriz, Frank Lloyd Dini
AIMS: To evaluate whether the clinical and echocardiographic correlates and the prognostic significance of right ventricular (RV) dysfunction are different in heart failure patients with reduced (HFrEF), mid-range (HFmrEF), or preserved (HFpEF) left ventricular ejection fraction. METHODS AND RESULTS: The study included 1663 patients with heart failure caused by ischaemic or hypertensive heart disease or by idiopathic cardiomyopathy. Left ventricular ejection fraction was <40% in 1123 patients (HFrEF), 40-49% in 156 patients (HFmrEF) and ≥50% in 384 patients (HFpEF)...
November 17, 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27862767/dynamics-of-cerebral-blood-flow-in-patients-with-mild-non-ischaemic-heart-failure
#13
Christian D Erkelens, Haye H van der Wal, Bauke M de Jong, Jan-Willem Elting, Remco Renken, Marleen Gerritsen, Peter Jan van Laar, Vincent M van Deursen, Peter van der Meer, Dirk J van Veldhuisen, Adriaan A Voors, Gert-Jan Luijckx
AIMS: Heart failure (HF) is associated with tissue hypoperfusion and congestion leading to organ dysfunction. Although cerebral blood flow (CBF) is preserved over a wide range of perfusion pressures in healthy subjects, it is impaired in end-stage HF. We aimed to compare CBF, autoregulation, and cognitive function in patients with mild non-ischaemic HF with healthy controls. METHODS AND RESULTS: Fifteen patients with mild idiopathic dilated cardiomyopathy and 15 matched healthy controls were studied...
November 14, 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27862700/rationale-for-and-design-of-the-true-ahf-trial-the-effects-of-ularitide-on-the-short-term-clinical-course-and-long-term-mortality-of-patients-with-acute-heart-failure
#14
Milton Packer, Richard Holcomb, William T Abraham, Stefan Anker, Kenneth Dickstein, Gerasimos Filippatos, Henry Krum, Aldo P Maggioni, John J V McMurray, Alexandre Mebazaa, Christopher O'Connor, Frank Peacock, Piotr Ponikowski, Frank Ruschitzka, Dirk J van Veldhuisen, Johannes Holzmeister
: The TRUE-AHF is a randomized, double-blind, parallel-group, placebo-controlled trial which is evaluating the effects of a 48-h infusion of ularitide (15 ng/kg/min) on the short- and long-term clinical course of patients with acute heart failure. Noteworthy features of the study include the early enrolment of patients following their initial clinical presentation (within 12 h), and entry blood pressure criteria and thresholds for the adjustment of drug infusion rates, which aim to minimize the risk of hypotension...
November 13, 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27862715/effect-of-cardiac-resynchronization-therapy-in-patients-with-diabetes-randomized-in-echocrt
#15
REVIEW
Matthias P Nägele, Jan Steffel, Michele Robertson, Jagmeet P Singh, Andreas J Flammer, Jeroen J Bax, Jeffrey S Borer, Kenneth Dickstein, Ian Ford, John Gorcsan, Daniel Gras, Henry Krum, Peter Sogaard, Johannes Holzmeister, William T Abraham, Josep Brugada, Frank Ruschitzka
AIMS: As patients with heart failure (HF) and concomitant diabetes carry a poor prognosis, this post-hoc subgroup analysis aimed to compare the outcomes of patients with and without diabetes randomized in the Echocardiography Guided Cardiac Resynchronization Therapy (EchoCRT) study. METHODS AND RESULTS: EchoCRT randomized patients with a QRS duration <130 ms and echocardiographic evidence of left ventricular dyssynchrony to CRT turned on (CRT=ON) vs. off (CRT=OFF) following device implantation...
November 11, 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27813322/role-of-functional-mitral-regurgitation-in-heart-failure-with-preserved-ejection-fraction-an-unrecognized-protagonist-reply
#16
LETTER
Katsuya Kajimoto, Teruo Takano
No abstract text is available yet for this article.
November 4, 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27813212/insights-into-mildly-dilated-cardiomyopathy-temporal-evolution-and-long-term-prognosis
#17
Marta Gigli, Davide Stolfo, Marco Merlo, Giulia Barbati, Federica Ramani, Francesca Brun, Bruno Pinamonti, Gianfranco Sinagra
AIMS: Mildly dilated cardiomyopathy (MDCM) has been proposed as a subtype of dilated cardiomyopathy (DCM) characterized by systolic dysfunction in the absence of significant LV dilatation. Few data on the characteristics and outcomes of MDCM patients are available. We sought to assess the main features and the long-term natural history of MDCM. METHODS AND RESULTS: From 1988 to 2010 we analysed all DCM patients consecutively evaluated at our Institution. MDCM was defined as LVEF <45% and LV end-diastolic volume index (LVEDVI) ≤70 mL/m(2) in women and ≤89 mL/m(2) in men...
November 4, 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27813223/truncating-titin-mutations-are-associated-with-a-mild-and-treatable-form-of-dilated-cardiomyopathy
#18
Joeri A Jansweijer, Karin Nieuwhof, Francesco Russo, Edgar T Hoorntje, Jan D H Jongbloed, Ronald H Lekanne Deprez, Alex V Postma, Marieke Bronk, Ingrid A W van Rijsingen, Simone de Haij, Elena Biagini, Paul L van Haelst, Jan van Wijngaarden, Maarten P van den Berg, Arthur A M Wilde, Marcel M A M Mannens, Rudolf A de Boer, Karin Y van Spaendonck-Zwarts, J Peter van Tintelen, Yigal M Pinto
AIMS: Truncating titin mutations (tTTN) occur in 25% of dilated cardiomyopathy (DCM) cases, but the phenotype and severity of disease they cause have not yet been systematically studied. We studied whether tTTN variants are associated with a clinically distinguishable form of DCM. METHODS AND RESULTS: We compared clinical data on DCM probands and relatives with a tTTN mutation (n = 45, n = 73), LMNA mutation (n = 28, n = 29), and probands who tested negative for both genes [idiopathic DCM (iDCM); n = 60]...
November 3, 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27790824/an-exploratory-randomized-control-study-of-combination-cytokine-and-adult-autologous-bone-marrow-progenitor-cell-administration-in-patients-with-ischaemic-cardiomyopathy-the-regenerate-ihd-clinical-trial
#19
Tawfiq Choudhury, Abdul Mozid, Steve Hamshere, Chia Yeo, Cyril Pellaton, Samer Arnous, Natalie Saunders, Pat Brookman, Ajay Jain, Didier Locca, Andrew Archbold, Charles Knight, Andrew Wragg, Ceri Davies, Peter Mills, Mahesh Parmar, Martin Rothman, Fizzah Choudry, Daniel A Jones, Samir Agrawal, John Martin, Anthony Mathur
AIMS: The effect of combined cytokine and cell therapy in ischaemic cardiomyopathy is unknown. Meta-analyses suggest improved cardiac function with cell therapy. The optimal cell delivery route remains unclear. We investigated whether granulocyte colony-stimulating factor (G-CSF) alone or in combination with intracoronary (i.c.) or intramyocardial (i.m.) injection of autologous bone marrow-derived cells (BMCs) improves cardiac function. METHODS AND RESULTS: Ninety patients with symptomatic ischaemic cardiomyopathy and no further treatment options were enrolled in the randomized, placebo-controlled, single-centre REGENERATE-IHD study...
October 28, 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27790819/precipitating-factors-and-90-day-outcome-of-acute-heart-failure-a-report-from-the-intercontinental-great-registry
#20
Mattia Arrigo, Etienne Gayat, Jiri Parenica, Shiro Ishihara, Jian Zhang, Dong-Ju Choi, Jin Joo Park, Khalid F Alhabib, Naoki Sato, Oscar Miro, Aldo P Maggioni, Yuhui Zhang, Jindrich Spinar, Alain Cohen-Solal, Theodore J Iwashyna, Alexandre Mebazaa
AIMS: Several clinical conditions may precipitate acute heart failure (AHF) and influence clinical outcome. In this study we hypothesized that precipitating factors are independently associated with 90-day risk of death in AHF. METHODS AND RESULTS: The study population consisted of 15 828 AHF patients from Europe and Asia. The primary outcome was 90-day all-cause mortality according to identified precipitating factors of AHF [acute coronary syndrome (ACS), infection, atrial fibrillation (AF), hypertension, and non-compliance]...
October 28, 2016: European Journal of Heart Failure
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