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European Journal of Heart Failure

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https://www.readbyqxmd.com/read/28052470/guided-left-ventricular-lead-placement-for-cardiac-resynchronization-therapy-an-opportunity-for-image-integration
#1
Jonathan M Behar, Ronak Rajani, Christopher Aldo Rinaldi
No abstract text is available yet for this article.
January 3, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28025867/brain-natriuretic-peptide-usefulness-in-very-elderly-dyspnoeic-patients-the-bed-study
#2
Matthieu Plichart, Galdric Orvoën, Patrick Jourdain, Laurent Quinquis, Joël Coste, Michele Escande, Patrick Friocourt, Elena Paillaud, François-Xavier Chedhomme, Florian Labourée, Clémence Boully, Athanase Benetos, Jean-Jacques Domerego, Michel Komajda, Olivier Hanon
AIMS: To evaluate the interest of brain natriuretic peptide (BNP) for heart failure (HF) diagnosis in very old patients. METHODS AND RESULTS: A total of 383 patients aged 80 years or older, hospitalized in geriatrics care for dyspnoea, had a BNP measurement at the acute phase. Independent cardiologists blinded to BNP values classified the patients into cardiac vs. respiratory aetiology according to the European Society of Cardiology guidelines. Mean (SD) age was 88...
December 26, 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28008698/prognostic-burden-of-heart-failure-recorded-in-primary-care-acute-hospital-admissions-or-both-a-population-based-linked-electronic-health-record-cohort-study-in-2-1-million-people
#3
Stefan Koudstaal, Mar Pujades-Rodriguez, Spiros Denaxas, Johannes M I H Gho, Anoop D Shah, Ning Yu, Riyaz S Patel, Chris P Gale, Arno W Hoes, John G Cleland, Folkert W Asselbergs, Harry Hemingway
AIMS: The prognosis of patients hospitalized for worsening heart failure (HF) is well described, but not that of patients managed solely in non-acute settings such as primary care or secondary outpatient care. We assessed the distribution of HF across levels of healthcare, and assessed the prognostic differences for patients with HF either recorded in primary care (including secondary outpatient care) (PC), hospital admissions alone, or known in both contexts. METHODS AND RESULTS: This study was part of the CALIBER programme, which comprises linked data from primary care, hospital admissions, and death certificates for 2...
December 23, 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28000341/heart-failure-in-haemoglobinopathies-pathophysiology-clinical-phenotypes-and%C3%A2-management
#4
REVIEW
Dimitrios Farmakis, Filippos Triposkiadis, John Lekakis, John Parissis
Hereditary haemoglobinopathies, mainly beta-thalassemia and sickle cell disease, constitute the most common monogenic disorders in humans, and although once geographically confined, they are currently globally distributed. They are demanding clinical entities that require multidisciplinary medical management. Despite their genotypic and phenotypic heterogeneity, the haemoglobinopathies share several similarities in pathophysiology, clinical manifestations, therapeutic requirements, and complications, among which heart failure (HF) represents a leading cause of mortality and morbidity...
December 20, 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27995696/prevention-of-the-development-of-heart-failure-with-preserved-ejection-fraction-by-the-phosphodiesterase-5a-inhibitor-vardenafil-in-rats-with-type-2-diabetes
#5
Csaba Mátyás, Balázs T Németh, Attila Oláh, Marianna Török, Mihály Ruppert, Dalma Kellermayer, Bálint A Barta, Gábor Szabó, Gábor Kökény, Eszter M Horváth, Beáta Bódi, Zoltán Papp, Béla Merkely, Tamás Radovits
AIMS: Heart failure with preserved ejection fraction (HFpEF) has a great epidemiological burden. The pathophysiological role of cyclic guanosine monophosphate (cGMP) signalling has been intensively investigated in HFpEF. Elevated levels of cGMP have been shown to exert cardioprotective effects in various cardiovascular diseases, including diabetic cardiomyopathy. We investigated the effect of long-term preventive application of the phosphodiesterase-5A (PDE5A) inhibitor vardenafil in diabetic cardiomyopathy-associated HFpEF...
December 19, 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27990720/a-functional-variant-of-the-neuropeptide-s-receptor-1-gene-modulates-clinical-outcomes-and-healthcare-utilization-in-patients-with-systolic-heart-failure-results-from-the-interdisciplinary-network-heart-failure-inh-study
#6
Christiane E Angermann, Mathias Kaspar, Almuth Marx, Sarah Kittel-Schneider, Dominik Menhofer, Stefan Störk, Georg Ertl, Katharina Domschke, Jürgen Deckert, Andreas Reif
AIMS: Psychopathologies may occur in heart failure (HF) and can be associated with adverse outcomes. Amongst neuropeptide S receptor gene functional sequence variants, the T-allele [asparagine(107)isoleucine, NPSR1 rs324981] has been identified as a risk factor for increased anxiety/overinterpretation of bodily symptoms. We investigated all-cause death and re-hospitalization (composite primary endpoint, CPEP) and healthcare utilization in patients hospitalized for decompensated systolic HF with the TT vs...
December 18, 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27990717/the-first-in-man-randomized-trial-of-a-beta3-adrenoceptor-agonist-in-chronic-heart-failure-the-beat-hf-trial
#7
Henning Bundgaard, Anna Axelsson, Jakob Hartvig Thomsen, Mathias Sørgaard, Klaus F Kofoed, Rasmus Hasselbalch, Natasha A S Fry, Nana Valeur, Søren Boesgaard, Finn Gustafsson, Lars Køber, Kasper Iversen, Helge H Rasmussen
AIMS: The third isotype of beta adrenergic receptors (β3 ARs) has distinctly different effects on cardiomyocytes compared with β1 and β2 ARs. Stimulation of β3 ARs may reduce cardiomyocyte Na(+) overload and reduce oxidative stress in heart failure (HF). We examined if treatment with the β3 AR agonist mirabegron increases LVEF in patients with HF. METHODS AND RESULTS: In a double-blind trial we randomly assigned 70 patients with NYHA class II-III HF and LVEF <40% at screening-echocardiography to receive mirabegron or placebo for 6 months as add-on to optimized standard therapy...
December 18, 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27976514/silent-disease-progression-in-clinically-stable-heart-failure
#8
REVIEW
Hani N Sabbah
Heart failure with reduced ejection fraction (HFrEF) is a progressive disorder whereby cardiac structure and function continue to deteriorate, often despite the absence of clinically apparent signs and symptoms of a worsening disease state. This silent yet progressive nature of HFrEF can contribute to the increased risk of death-even in patients who are 'clinically stable', or who are asymptomatic or only mildly symptomatic-because it often goes undetected and/or undertreated. Current therapies are aimed at improving clinical symptoms, and several agents more directly target the underlying causes of disease; however, new therapies are needed that can more fully address factors responsible for underlying progressive cardiac dysfunction...
December 14, 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27976479/are-two-crutches-better-than-one-the-ongoing-dilemma-on-the-effects-and-need-of-left-ventricular-unloading-during-veno-arterial-extracorporeal-membrane-oxygenation
#9
EDITORIAL
Roberto Lorusso
No abstract text is available yet for this article.
December 14, 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27976478/ferritin-levels-and-risk-of-heart-failure-the-atherosclerosis-risk-in-communities-study
#10
Odilson M Silvestre, Alexandra Gonçalves, Wilson Nadruz, Brian Claggett, David Couper, John H Eckfeldt, James S Pankow, Stefan D Anker, Scott D Solomon
AIMS: Severe iron overload is associated with cardiac damage, while iron deficiency has been related to worse outcomes in subjects with heart failure (HF). This study investigated the relationship between ferritin, a marker of iron status, and the incidence of HF in a community-based cohort. METHODS AND RESULTS: We examined 1063 participants who were free of heart failure from the Atherosclerosis Risk in Communities (ARIC) Study in whom ferritin serum levels were measured at baseline (1987-1989)...
December 14, 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27943554/does-aspirin-detract-from-the-benefits-of-mineralocorticoid-receptor-antagonists-in-patients-with-heart-failure-and-a-reduced-left-ventricular-ejection-fraction-probably
#11
EDITORIAL
John G F Cleland
No abstract text is available yet for this article.
December 11, 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27928880/a-novel-clinical-score-intertak-diagnostic-score-to-differentiate-takotsubo-syndrome-from-acute-coronary-syndrome-results-from-the-international-takotsubo-registry
#12
Jelena R Ghadri, Victoria L Cammann, Stjepan Jurisic, Burkhardt Seifert, L Christian Napp, Johanna Diekmann, Dana Roxana Bataiosu, Fabrizio D'Ascenzo, Katharina J Ding, Annahita Sarcon, Elycia Kazemian, Tanja Birri, Frank Ruschitzka, Thomas F Lüscher, Christian Templin
AIMS: Clinical presentation of takotsubo syndrome (TTS) mimics acute coronary syndrome (ACS) and does not allow differentiation. We aimed to develop a clinical score to estimate the probability of TTS and to distinguish TTS from ACS in the acute stage. METHODS AND RESULTS: Patients with TTS were recruited from the International Takotsubo Registry ( www.takotsubo-registry.com) and ACS patients from the leading hospital in Zurich. A multiple logistic regression for the presence of TTS was performed in a derivation cohort (TTS, n = 218; ACS, n = 436)...
December 7, 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27917598/heart-rate-from-heart-failure-to-chronic-diseases-and-cancer-is-there-a-role-for-supportive-care-by-heart-rate-reduction
#13
EDITORIAL
Michael Böhm
No abstract text is available yet for this article.
December 4, 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27905161/the-impact-of-co-morbidity-burden-on-appropriate-implantable-cardioverter-defibrillator-therapy-and-all-cause-mortality-insight-from-danish-nationwide-clinical-registers
#14
Anne Christine Ruwald, Michael Vinther, Gunnar H Gislason, Jens Brock Johansen, Jens Cosedis Nielsen, Helen Høgh Petersen, Sam Riahi, Christian Jons
AIMS: In a nationwide cohort of primary (PP-ICD) and secondary prevention (SP-ICD) implantable cardioverter defibrillator (ICD) patients, we aimed to investigate the association between co-morbidity burden and risk of appropriate ICD therapy and mortality. METHODS AND RESULTS: We identified all patients >18 years, implanted with first-time PP-ICD (n = 1873) or SP-ICD (n = 2461) in Denmark from 2007 to 2012. Co-morbidity was identified in administrative registers of hospitalization and drug prescription from pharmacies...
December 1, 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27891745/cardiac-extracellular-matrix-is-associated-with-adverse-outcome-in-patients-with-chronic-heart-failure
#15
Franz Duca, Caroline Zotter-Tufaro, Andreas A Kammerlander, Adelheid Panzenböck, Stefan Aschauer, Daniel Dalos, Benedikt Köll, Benedikt Börries, Hermine Agis, Renate Kain, Klaus Aumayr, Florian Klinglmüller, Julia Mascherbauer, Diana Bonderman
AIMS: Accumulation of extracellular matrix (ECM) is known to play a crucial role in the pathophysiology of heart failure (HF). However, its prognostic relevance is poorly investigated. METHODS AND RESULTS: A total of 73 HF patients who underwent LV endomyocardial biopsy were enrolled in our study. ECM area was quantified by TissueFAXS and ImageJ software. Patients were followed-up at 6-month intervals. The study endpoint was defined as hospitalization for a cardiac reason and/or cardiac death...
November 27, 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27891719/myocardial-strain-to-detect-subtle-left-ventricular-systolic-dysfunction
#16
REVIEW
Laurens F Tops, Victoria Delgado, Nina Ajmone Marsan, Jeroen J Bax
In daily clinical practice, LV systolic function is routinely assessed with the use of two-dimensional echocardiography. Using biplane LV end-diastolic and end-systolic volumes, LVEF is calculated. The introduction of real-time three-dimensional echocardiography has improved the accuracy of echocardiographic assessment of LVEF. However, calculated LVEF may not truly represent LV systolic function in specific cardiac diseases or when subtle LV dysfunction is present. Two-dimensional speckle tracking echocardiography enables assessment of myocardial strain, thereby providing detailed information on global and regional LV deformation...
November 27, 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27878925/left-ventricular-deformation-at-rest-predicts-exercise-induced-elevation-in-pulmonary-artery-wedge-pressure-in-patients-with-unexplained-dyspnoea
#17
Tor Biering-Sørensen, Mário Santos, Jose Rivero, Shane D McCullough, Erin West, Alexander R Opotowsky, Aaron B Waxman, David M Systrom, Amil M Shah
AIMS: Impaired left ventricular (LV) deformation despite preserved LV ejection fraction (LVEF) is common and predicts outcomes in heart failure with preserved LVEF. We hypothesized that impaired LV deformation at rest is a marker of impaired cardiac systolic and diastolic reserve, and aimed to determine whether resting longitudinal (LS) and circumferential strain (CS) are associated with invasively measured haemodynamic response to exercise in patients with dyspnoea and a normal LVEF...
November 22, 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27873428/data-and-safety-monitoring-board-evaluation-and-management-of-a-renal-adverse-event-signal-in-topcat
#18
REVIEW
Michael R Bristow, Kavita Sharma, Susan F Assmann, Stuart Linas, Bernard J Gersh, Christine Grady, Madeline Murguia Rice, Steven Singh, Robin Boineau, Sonja M McKinlay, Barry H Greenberg
Clinical trial Data and Safety Monitoring Boards (DSMBs) have a primary obligation of ensuring study participant safety, while maintaining trial integrity. The role of DSMBs is expanding, and ideally should include post-hoc reporting of deliberative processes related to clinically important safety issues or factors that could impact on future trial designs. We describe how the TOPCAT DSMB detected, investigated, and adjudicated an unexpectedly large renal adverse event signal midway through the trial, and offer general guidelines for dealing with similar unanticipated occurrences in future trials...
November 21, 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27873389/sildenafil-unbridled-optimism-and-heart-failure-with-preserved-ejection-fraction
#19
EDITORIAL
Yogesh N V Reddy, Barry A Borlaug
No abstract text is available yet for this article.
November 21, 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27873388/effects-of-sildenafil-on-cardiac-structure-and-function-cardiopulmonary-exercise-testing-and-health-related-quality-of-life-measures-in-heart-failure-patients-with-preserved-ejection-fraction-and-pulmonary-hypertension
#20
Licette C Y Liu, Yoran M Hummel, Peter van der Meer, Rolf M F Berger, Kevin Damman, Dirk J van Veldhuisen, Adriaan A Voors, Elke S Hoendermis
AIMS: We recently showed that sildenafil did not improve pulmonary pressures and exercise capacity in a cohort of patients with heart failure and preserved ejection fraction (HFpEF) and predominantly postcapillary pulmonary hypertension. Here, we present the effects of sildenafil on cardiac structure and function, cardiopulmonary exercise testing, laboratory parameters and health-related quality of life measures. METHODS AND RESULTS: Fifty-two HFpEF patients with pulmonary hypertension (mean pulmonary artery pressure >25 mmHg; pulmonary artery wedge pressure >15 mmHg) were randomized to sildenafil 60 mg three times a day or placebo and treated for 12 weeks...
November 21, 2016: European Journal of Heart Failure
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