journal
MENU ▼
Read by QxMD icon Read
search

Neuro-oncology

journal
https://www.readbyqxmd.com/read/28204639/comparison-of-2d-rano-and-volumetric-methods-for-assessment-of-recurrent-glioblastoma-treated-with-bevacizumab-a-report-from-the-belob-trial
#1
Renske Gahrmann, Martin van den Bent, Bronno van der Holt, René Michel Vernhout, Walter Taal, Maaike Vos, Jan Cees de Groot, Laurens Victor Beerepoot, Jan Buter, Zwenneke Hendrieke Flach, Monique Hanse, Bas Jasperse, Marion Smits
No abstract text is available yet for this article.
February 13, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28204572/o-2-18f-fluoroethyl-l-tyrosine-pet-for-evaluation-of-brain-metastasis-recurrence-after-radiotherapy-an-effectiveness-and-cost-effectiveness-analysis
#2
Alexander Heinzel, Dirk Müller, Sareh Said Yekta-Michael, Garry Ceccon, Karl-Josef Langen, Felix M Mottaghy, Martin Wiesmann, Martin Kocher, Elke Hattingen, Norbert Galldiks
No abstract text is available yet for this article.
February 13, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28204560/the-clinical-value-of-patient-derived-glioblastoma-tumorspheres-in-predicting-treatment-response
#3
Quintino Giorgio D'Alessandris, Mauro Biffoni, Maurizio Martini, Daniele Runci, Mariachiara Buccarelli, Tonia Cenci, Michele Signore, Louis Stancato, Alessandro Olivi, Ruggero De Maria, Luigi M Larocca, Lucia Ricci-Vitiani, Roberto Pallini
No abstract text is available yet for this article.
February 13, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28201779/comprehensive-molecular-characterization-of-multifocal-glioblastoma-proves-its-monoclonal-origin-and-reveals-novel-insights-into-clonal-evolution-and-heterogeneity-of-glioblastomas
#4
Khalil Abou-El-Ardat, Michael Seifert, Kerstin Becker, Sophie Eisenreich, Matthias Lehmann, Karl Hackmann, Andreas Rump, Gerrit Meijer, Beatriz Carvalho, Achim Temme, Gabriele Schackert, Evelin Schröck, Dietmar Krex, Barbara Klink
No abstract text is available yet for this article.
February 13, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28201752/characteristics-of-h3-k27m-mutant-gliomas-in-adults
#5
David Meyronet, Maud Esteban-Mader, Charlotte Bonnet, Marie-Odile Joly, Emmanuelle Uro-Coste, Alexandra Amiel-Benouaich, Fabien Forest, Cécilia Rousselot-Denis, Fanny Burel-Vandenbos, Véronique Bourg, Jacques Guyotat, Tanguy Fenouil, Anne Jouvet, Jérôme Honnorat, François Ducray
No abstract text is available yet for this article.
February 13, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28201746/evaluating-the-significance-of-density-localization-and-pd-1-pd-l1-immunopositivity-of-mononuclear-cells-in-the-clinical-course-of-lung-adenocarcinoma-patients-with-brain-metastasis
#6
Vanda Téglási, Lilla Reiniger, Katalin Fábián, Orsolya Pipek, Irén Csala, Attila G Bagó, Péter Várallyai, Laura Vízkeleti, Lívia Rojkó, József Tímár, Balázs Döme, Zoltán Szállási, Charles Swanton, Judit Moldvay
No abstract text is available yet for this article.
February 13, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28115578/immunosuppressive-tumor-infiltrating-myeloid-cells-mediate-adaptive-immune-resistance-via-a-pd-1-pd-l1-mechanism-in-glioblastoma
#7
Joseph P Antonios, Horacio Soto, Richard G Everson, Diana Moughon, Joey R Orpilla, Namjo P Shin, Shaina Sedighim, Janet Treger, Sylvia Odesa, Alexander Tucker, William H Yong, Gang Li, Timothy F Cloughesy, Linda M Liau, Robert M Prins
BACKGROUND: Adaptive immune resistance in the tumor microenvironment appears to attenuate the immunotherapeutic targeting of glioblastoma (GBM). In this study, we identified a tumor-infiltrating myeloid cell (TIM) population that expands in response to dendritic cell (DC) vaccine treatment. The aim of this study was to understand how this programmed death ligand 1 (PD-L1)-expressing population restricts activation and tumor-cytolytic function of vaccine-induced tumor-infiltrating lymphocytes (TILs)...
January 23, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28104717/clinical-targeted-exome-based-sequencing-in-combination-with-genome-wide-copy-number-profiling-precision-medicine-analysis-of-203-pediatric-brain-tumors
#8
Shakti H Ramkissoon, Pratiti Bandopadhayay, Jaeho Hwang, Lori A Ramkissoon, Noah F Greenwald, Steven E Schumacher, Ryan O'Rourke, Nathan Pinches, Patricia Ho, Hayley Malkin, Claire Sinai, Mariella Filbin, Ashley Plant, Wenya Linda Bi, Michael S Chang, Edward Yang, Karen D Wright, Peter E Manley, Matthew Ducar, Sanda Alexandrescu, Hart Lidov, Ivana Delalle, Liliana C Goumnerova, Alanna J Church, Katherine A Janeway, Marian H Harris, Laura E MacConaill, Rebecca D Folkerth, Neal I Lindeman, Charles D Stiles, Mark W Kieran, Azra H Ligon, Sandro Santagata, Adrian M Dubuc, Susan N Chi, Rameen Beroukhim, Keith L Ligon
BACKGROUND: Clinical genomics platforms are needed to identify targetable alterations, but implementation of these technologies and best practices in routine clinical pediatric oncology practice are not yet well established. METHODS: Profile is an institution-wide prospective clinical research initiative that uses targeted sequencing to identify targetable alterations in tumors. OncoPanel, a multiplexed targeted exome-sequencing platform that includes 300 cancer-causing genes, was used to assess single nucleotide variants and rearrangements/indels...
January 19, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28096493/combining-standard-clinical-blood-values-for-improving-survival-prediction-in-patients-with-newly-diagnosed-brain-metastases-development-and-validation-of-the-labbm-score
#9
Anna S Berghoff, Fabian Wolpert, Tim Holland-Letz, Romina Koller, Georg Widhalm, Brigitte Gatterbauer, Karin Dieckmann, Peter Birner, Rupert Bartsch, Christoph C Zielinski, Michael Weller, Matthias Preusser
BACKGROUND: We aimed to investigate the potential of standard hematologic and serum biochemical parameters to provide an independent and substantial contribution to the prediction of survival in patients with newly diagnosed brain metastases (BM). METHODS: Hemoglobin, white blood cell count, platelet count, serum albumin, creatinine, lactate dehydrogenase (LDH), and C-reactive protein (CRP) were assessed at diagnosis of BM in a discovery cohort of 1200 cancer patients...
January 17, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28082416/a-brain-penetrant-raf-dimer-antagonist-for-the-noncanonical-braf-oncoprotein-of-pediatric-low-grade-astrocytomas
#10
Yu Sun, John A Alberta, Catherine Pilarz, David Calligaris, Emily J Chadwick, Shakti H Ramkissoon, Lori A Ramkissoon, Veronica Matia Garcia, Emanuele Mazzola, Liliana Goumnerova, Michael Kane, Zhan Yao, Mark W Kieran, Keith L Ligon, William C Hahn, Levi A Garraway, Neal Rosen, Nathanael S Gray, Nathalie Y Agar, Sara J Buhrlage, Rosalind A Segal, Charles D Stiles
BACKGROUND: Activating mutations or structural rearrangements in BRAF are identified in roughly 75% of all pediatric low-grade astrocytomas (PLGAs). However, first-generation RAF inhibitors approved for adult melanoma have poor blood-brain penetrance and are only effective on tumors that express the canonical BRAFV600E oncoprotein, which functions as a monomer. These drugs (type I antagonists that target the "DFG-in" conformation of the kinase) fail to block signaling via KIAA1549:BRAF, a truncation/fusion BRAF oncoprotein which functions as a dimer and is found in the most common form of PLGA...
January 12, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28082415/smo-mutation-status-defines-a-distinct-and-frequent-molecular-subgroup-in-olfactory-groove-meningiomas
#11
Julien Boetto, Franck Bielle, Marc Sanson, Matthieu Peyre, Michel Kalamarides
BACKGROUND: Meningiomas are the most common primary intracranial tumors in adults. Identification of SMO and AKT1 mutations in meningiomas has raised the hope for targeted therapies. It would be useful to know the precise frequency of these mutations in anatomical subgroups and clarify their prognostic value. METHODS: We used the Sanger sequencing technique to characterize 79 samples of olfactory groove meningiomas for SMO (L412F and W535L) and AKT1 (E17K) mutations...
January 12, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28062831/glioblastoma-on-a-microfluidic-chip-generating-pseudopalisades-and-enhancing-aggressiveness-through-blood-vessel-obstruction-events
#12
Jose M Ayuso, Rosa Monge, Alicia Martínez-González, María Virumbrales-Muñoz, Guillermo A Llamazares, Javier Berganzo, Aurelio Hernández-Laín, Jorge Santolaria, Manuel Doblaré, Christopher Hubert, Jeremy N Rich, Pilar Sánchez-Gómez, Víctor M Pérez-García, Ignacio Ochoa, Luis J Fernández
BACKGROUND: Glioblastoma (GBM) is one of the most lethal tumor types. Hypercellular regions, named pseudopalisades, are characteristic in these tumors and have been hypothesized to be waves of migrating glioblastoma cells. These "waves" of cells are thought to be induced by oxygen and nutrient depletion caused by tumor-induced blood vessel occlusion. Although the universal presence of these structures in GBM tumors suggests that they may play an instrumental role in GBM's spread and invasion, the recreation of these structures in vitro has remained challenging...
January 6, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28062830/dissecting-inherent-intratumor-heterogeneity-in-patient-derived-glioblastoma-culture-models
#13
Jian Teng, Cintia Carla da Hora, Rami S Kantar, Ichiro Nakano, Hiroaki Wakimoto, Tracy T Batchelor, E Antonio Chiocca, Christian E Badr, Bakhos A Tannous
BACKGROUND: Molecular profile of glioblastoma multiforme (GBM) revealed 4 subtypes, 2 of which, proneural and mesenchymal, have been predominantly observed, with the latter displaying a more aggressive phenotype and increased therapeutic resistance. Single-cell RNA sequencing revealed that multiple subtypes actually reside within the same tumor, suggesting cellular heterogeneity in GBM. Further, plasticity between these 2 subtypes is observed during tumor recurrence and in response to radiation therapy...
January 6, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28053137/activation-of-cecr1-in-m2-like-tams-promotes-paracrine-stimulation-mediated-glial-tumor-progression
#14
Changbin Zhu, Dana Mustafa, Ping-Pin Zheng, Marcel van der Weiden, Andrea Sacchetti, Maarten Brandt, Ihsan Chrifi, Dennie Tempel, Pieter J M Leenen, Dirk Jan Duncker, Caroline Cheng, Johan M Kros
BACKGROUND: The majority of glioma-associated microglia/macrophages have been identified as M2-type macrophages with immune suppressive and tumor supportive action. Recently, the extracellular adenosine deaminase protein Cat Eye Syndrome Critical Region Protein 1 (CECR1) was shown to regulate macrophage maturation. In this study, we investigate the role of CECR1 in the regulation of the glioma-associated macrophage response. METHODS: Expression of CECR1 was assessed in human glioma samples...
January 3, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28040713/the-impact-of-body-mass-index-and-height-on-the-risk-for-glioblastoma-and-other-glioma-subgroups-a-large-prospective-cohort-study
#15
Markus K H Wiedmann, Cathrine Brunborg, Antonio Di Ieva, Kristina Lindemann, Tom B Johannesen, Lars Vatten, Eirik Helseth, John A Zwart
BACKGROUND: Glioma comprises a heterogeneous group of mostly malignant brain tumors, whereof glioblastoma (GBM) represents the largest and most lethal subgroup. Body height and body mass index (BMI) are risk factors for other cancers, but no previous study has examined anthropometric data in relation to different glioma subgroups. METHODS: This prospective cohort study includes 1.8 million Norwegian women and men between ages 14 and 80 years at baseline. Body weight and height were measured, and incident cases of glioma were identified by linkage to the National Cancer Registry...
December 31, 2016: Neuro-oncology
https://www.readbyqxmd.com/read/28040712/comment-on-hatzoglou-et-al-dynamic-contrast-enhanced-mri-perfusion-versus-18fdg-pet-ct-in-differentiating-brain-tumor-progression-from-radiation-injury
#16
LETTER
Francesco Cicone, Norbert Galldiks, Giuseppe Minniti, Christian P Filss, Francesco Scopinaro, John O Prior, Nathalie L Albert, Karl-Josef Langen
No abstract text is available yet for this article.
December 31, 2016: Neuro-oncology
https://www.readbyqxmd.com/read/28040711/-comment-on-hatzoglou-et-al-dynamic-contrast-enhanced-mri-perfusion-vs-18fdg-pet-ct-in-differentiating-brain-tumor-progression-from-radiation-injury-reply
#17
LETTER
Robert J Young, T Jonathan Yang, Vaios Hatzoglou, Gary Ulaner, Antonio Omuro
No abstract text is available yet for this article.
December 31, 2016: Neuro-oncology
https://www.readbyqxmd.com/read/28040710/rest-represses-mir-124-and-mir-203-to-regulate-distinct-oncogenic-properties-of-glioblastoma-stem-cells
#18
Anantha L Marisetty, Sanjay K Singh, Tran N Nguyen, Cristian Coarfa, Bin Liu, Sadhan Majumder
BACKGROUND: Glioblastoma (GBM) is one of the most common, aggressive, and invasive human brain tumors. There are few reliable mechanism-based therapeutic approaches for GBM patients. The transcriptional repressor RE1 silencing transcriptional factor (REST) regulates the oncogenic properties of a class of GBM stem-like cells (high-REST [HR]-GSCs) in humans. However, it has been unclear whether REST represses specific targets to regulate specific oncogenic functions or represses all targets with overlapping functions in GSCs...
December 31, 2016: Neuro-oncology
https://www.readbyqxmd.com/read/28039369/long-term-control-and-partial-remission-after-initial-pseudoprogression-of-glioblastoma-by-anti-pd-1-treatment-with-nivolumab
#19
LETTER
Patrick Roth, Antonios Valavanis, Michael Weller
No abstract text is available yet for this article.
December 29, 2016: Neuro-oncology
https://www.readbyqxmd.com/read/28039368/long-term-neurologic-health-and-psychosocial-function-of-adult-survivors-of-childhood-medulloblastoma-pnet-a-report-from-the-childhood-cancer-survivor-study
#20
Allison A King, Kristy Seidel, Chongzhi Di, Wendy M Leisenring, Stephanie Mabry Perkins, Kevin R Krull, Charles A Sklar, Daniel M Green, Gregory T Armstrong, Lonnie K Zeltzer, Elizabeth Wells, Marilyn Stovall, Nicole J Ullrich, Kevin C Oeffinger, Leslie L Robison, Roger J Packer
BACKGROUND: Medulloblastoma is the most common malignant childhood brain tumor, although long-term risks for chronic neurologic health and psychosocial functioning in aging adult survivors are incompletely characterized. METHODS: The Childhood Cancer Survivor Study (CCSS) includes 380 five-year survivors of medulloblastoma/primitive neuroectodermal tumor (PNET; median age at follow-up: 30 y, interquartile range 24-36) and sibling comparison (n = 4031). Cumulative incidence of neurologic health conditions was reported...
December 29, 2016: Neuro-oncology
journal
journal
34661
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"