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Biomedical Microdevices

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https://www.readbyqxmd.com/read/29781041/a-bead-based-immunogold-silver-staining-assay-on-capillary-driven-microfluidics
#1
Ngoc M Pham, Sebastian Rusch, Yuksel Temiz, Robert D Lovchik, Hans-Peter Beck, Walter Karlen, Emmanuel Delamarche
Point-of-care (POC) diagnostics are critically needed for the detection of infectious diseases, particularly in remote settings where accurate and appropriate diagnosis can save lives. However, it is difficult to implement immunoassays, and specifically immunoassays relying on signal amplification using silver staining, into POC diagnostic devices. Effective immobilization of antibodies in such devices is another challenge. Here, we present strategies for immobilizing capture antibodies (cAbs) in capillary-driven microfluidic chips and implementing a gold-catalyzed silver staining reaction...
May 21, 2018: Biomedical Microdevices
https://www.readbyqxmd.com/read/29754170/cardiac-support-device-asd-delivers-bone-marrow-stem-cells-repetitively-to-epicardium-has-promising-curative-effects-in-advanced-heart-failure
#2
Shizhong Yue, Muhammad Naveed, Wang Gang, Dingding Chen, Zhijie Wang, Feng Yu, Xiaohui Zhou
Ventricular restraint therapy is a non-transplant surgical option for the management of advanced heart failure (HF). To augment the therapeutic applications, it is hypothesized that ASD shows remarkable capabilities not only in delivering stem cells but also in dilated ventricles. Male SD rats were divided into four groups (n = 6): normal, HF, HF + ASD, and HF + ASD-BMSCs respectively. HF was developed by left anterior descending (LAD) coronary artery ligation in all groups except normal group. Post-infarcted electrocardiography (ECG) and brain natriuretic peptide (BNP) showed abnormal heart function in all model groups and HF + ASD-BMSCs group showed significant improvement as compared to other HF, HF + ASD groups on day 30...
May 12, 2018: Biomedical Microdevices
https://www.readbyqxmd.com/read/29736756/correction-to-design-and-validation-of-an-osteochondral-bioreactor-for-the-screening-of-treatments-for-osteoarthritis
#3
Derek A Nichols, Inderbir S Sondh, Steven R Little, Paolo Zunino, Riccardo Gottardi
The original version of this article unfortunately contained a mistake.
May 8, 2018: Biomedical Microdevices
https://www.readbyqxmd.com/read/29680876/solid-state-nanopore-fabrication-in-licl-by-controlled-dielectric-breakdown
#4
Julian Bello, Jiwook Shim
Nanopore fabrication via the controlled dielectric breakdown (CDB) method offers an opportunity to create solid-state nanopores directly in salt solution with sub-nanometer precision. Driven by trap assisted current tunneling, the method uses localized defects, or traps, in the dielectric material to isolate a breakdown point and fabricate a single pore in less than 10 minutes. Here we present an approach to controlled dielectric breakdown of SiNx in which the nanopore is fabricated in LiCl buffer instead of the traditional KCl buffer...
April 21, 2018: Biomedical Microdevices
https://www.readbyqxmd.com/read/29654553/study-on-real-time-force-feedback-for-a-master-slave-interventional-surgical-robotic-system
#5
Shuxiang Guo, Yuan Wang, Nan Xiao, Youxiang Li, Yuhua Jiang
In robot-assisted catheterization, haptic feedback is important, but is currently lacking. In addition, conventional interventional surgical robotic systems typically employ a master-slave architecture with an open-loop force feedback, which results in inaccurate control. We develop herein a novel real-time master-slave (RTMS) interventional surgical robotic system with a closed-loop force feedback that allows a surgeon to sense the true force during remote operation, provide adequate haptic feedback, and improve control accuracy in robot-assisted catheterization...
April 13, 2018: Biomedical Microdevices
https://www.readbyqxmd.com/read/29651562/the-evaluation-of-e-faecalis-colonies-dissolution-ability-of-sodium-hypochlorite-in-microenvironment-by-a-novel-device
#6
Xiaoqiang Sun, Shaorong Li, Shujing Wang, Chunxiong Luo, Benxiang Hou
Enterococcus faecalis(E. faecalis) is a common microorganism could be isolated from the infected canals, especially in the case of refractory apical periodontitis. Due to its ability to invade the dentinal tubules and highly resistant to antimicrobial strategies, the thorough debridement of E.faecalis is hard to achieve. And that may be one of the reasons to cause reinfection and therapeutic failure. According to the anatomy of dentinal tubules published before and the results of our team previous work, we designed six types of microtubes with different sizes...
April 12, 2018: Biomedical Microdevices
https://www.readbyqxmd.com/read/29644437/a-paperfluidic-platform-to-detect-neisseria-gonorrhoeae-in-clinical-samples
#7
Audrey L Horst, Justin M Rosenbohm, Nikunja Kolluri, Justin Hardick, Charlotte A Gaydos, Mario Cabodi, Catherine M Klapperich, Jacqueline C Linnes
Globally, the microbe Neisseria gonorrhoeae (NG) causes 106 million newly documented sexually transmitted infections each year. Once appropriately diagnosed, NG infections can be readily treated with antibiotics, but high-risk patients often do not return to the clinic for treatment if results are not provided at the point of care. A rapid, sensitive molecular diagnostic would help increase NG treatment and reduce the prevalence of this sexually transmitted disease. Here, we report on the design and development of a rapid, highly sensitive, paperfluidic device for point-of-care diagnosis of NG...
April 11, 2018: Biomedical Microdevices
https://www.readbyqxmd.com/read/29627886/operation-evaluation-in-human-of-a-novel-remote-controlled-vascular-interventional-robot
#8
Xianqiang Bao, Shuxiang Guo, Nan Xiao, Youxiang Li, Cheng Yang, Rui Shen, Jinxin Cui, Yuhua Jiang, Xinke Liu, Keyun Liu
Remote-controlled vascular interventional robots (RVIRs) are being developed to increase the accuracy of surgical operations and reduce the number of occupational risks sustained by intervening physicians, such as radiation exposure and chronic neck/back pain. However, complex control of the RVIRs improves the doctor's operation difficulty and reduces the operation efficiency. Furthermore, incomplete sterilization of the RVIRs will increase the risk of infection, or even cause medical accidents. In this study, we introduced a novel method that provides higher operation efficiency than a previous prototype and allows for complete robot sterilization...
April 7, 2018: Biomedical Microdevices
https://www.readbyqxmd.com/read/29610988/operating-force-information-on-line-acquisition-of-a-novel-slave-manipulator-for-vascular-interventional-surgery
#9
Yan Zhao, Shuxiang Guo, Nan Xiao, Yuxin Wang, Youxiang Li, Yuhua Jiang
Vascular interventional surgery has its advantages compared to traditional operation. Master-slave robotic technology can further improve the operation accuracy, efficiency and safety of this complicated and high risk surgery. However, on-line acquisition of operating force information of catheter and guidewire remains to be a significant obstacle on the path to enhancing robotic surgery safety. Thus, a novel slave manipulator is proposed in this paper to realize on-line sensing of guidewire torsional operating torque and axial operation force during robotic assisted operations...
April 2, 2018: Biomedical Microdevices
https://www.readbyqxmd.com/read/29594810/a-sample-to-answer-droplet-magnetofluidic-assay-platform-for-quantitative-methylation-specific-pcr
#10
Alejandro Stark, Dong Jin Shin, Tza-Huei Wang
Dysregulation of DNA methylation has been identified as an epigenetic biomarker for numerous cancer types. Gene-specific identification techniques relying on methylation-specific PCR (MSP) require a lengthy manual benchtop process that is susceptible to human-error and contamination. This MSP assay requires a series of discrete sample processing steps including genomic DNA extraction, bisulfite conversion and readout via PCR. In this work, we present a streamlined assay platform utilizing droplet magnetofluidic principles for integration of all sample processing steps required to obtain quantitative MSP signal from raw biological samples...
March 28, 2018: Biomedical Microdevices
https://www.readbyqxmd.com/read/29594704/bioprinted-gelatin-hydrogel-platform-promotes-smooth-muscle-cell-contractile-phenotype-maintenance
#11
Ajay Tijore, Jean-Marc Behr, Scott Alexander Irvine, Vrushali Baisane, Subbu Venkatraman
Three dimensional (3D) bioprinting has been proposed as a method for fabricating tissue engineered small diameter vascular prostheses. This technique not only involves constructing the structural features to obtain a desired pattern but the morphology of the pattern may also be used to influence the behavior of seeded cells. Herein, we 3D bioprinted a gelatin hydrogel microchannel construct to promote and preserve the contractile phenotype of vascular smooth muscle cells (vSMCs), which is crucial for vasoresponsiveness...
March 28, 2018: Biomedical Microdevices
https://www.readbyqxmd.com/read/29564563/a-stretchable-conductive-polypyrrole-polydimethylsiloxane-device-fabricated-by-simple-soft-lithography-and-oxygen-plasma-treatment
#12
Xu-Cheng Guo, Wei-Wen Hu, Say Hwa Tan, Chia-Wen Tsao
This paper reports a simple method used to fabricate a stretchable conductive polypyrrole (PPy) rough pore-shape polydimethylsiloxane (p-PDMS) device. An abrasive paper is first used to imprint rough micro-structures on the SU-8 micromold. The p-PDMS microchannel is then fabricated using a standard soft-lithography process. An oxygen plasma treatment is then applied to form an irreversible sealing between the microchannel and a blank cover PDMS. The conductive layer is formed by injecting the PPy mixture into the microchannel which polymerizes in the rough pore-shape micro-structures; The PPy/p-PDMS hybrid device shows good electrical property and stretchability...
March 21, 2018: Biomedical Microdevices
https://www.readbyqxmd.com/read/29549438/pre-clinical-evaluation-of-oxychip-for-long-term-epr-oximetry
#13
Huagang Hou, Nadeem Khan, Sangeeta Gohain, M Lakshmi Kuppusamy, Periannan Kuppusamy
Tissue oxygenation is a critical parameter in various pathophysiological situations including cardiovascular disease and cancer. Hypoxia can significantly influence the prognosis of solid malignancies and the efficacy of their treatment by radiation or chemotherapy. Electron paramagnetic resonance (EPR) oximetry is a reliable method for repeatedly assessing and monitoring oxygen levels in tissues. Lithium octa-n-butoxynaphthalocyanine (LiNc-BuO) has been developed as a probe for biological EPR oximetry, especially for clinical use...
March 16, 2018: Biomedical Microdevices
https://www.readbyqxmd.com/read/29524045/closed-loop-control-of-microscopic-particles-incorporating-steady-streaming-and-visual-feedback
#14
Avi Abadi, Gabor Kosa
Automatic manipulation of microscopic particles is very important in biology, especially in new lab-on-chip systems for automatic testing and DNA manipulation. We suggest a particle manipulation system (PMS) based on vibrating piezoelectric beams creating steady streaming flow in a viscous liquid. The flow is nearly unidirectional and it is used to control the position and velocity of the particles in the workspace of the PMS. The particles position in the PMS are controlled by visual feedback. This study presents the manipulation method, the system's model describing its behavior and characterizes experimentally its performance...
March 9, 2018: Biomedical Microdevices
https://www.readbyqxmd.com/read/29511829/a-novel-approach-to-producing-uniform-3-d-tumor-spheroid-constructs-using-ultrasound-treatment
#15
Solmaz Karamikamkar, Ehsan Behzadfar, Karen C Cheung
Producing three-dimensional (3-D) multicellular tumor spheroids (TSs) is valuable for characterizing anticancer drugs since they provide a more representative model of the 3-D in vivo tumor than conventional two-dimensional (2-D) monolayer culture. The interaction of tumor cells with the extracellular matrix (ECM) in a 3-D culture environment is more similar to a tumor in vivo than in a 2-D environment; cell-cell and cell-ECM interaction can influence cell behaviour, such as in response to drug treatment. In vitro tumor spheroid models have been developed using microfluidic systems to generate 3-D hydrogel beads containing components of alginate and ECM protein, such as collagen, with high uniformity and throughput...
March 6, 2018: Biomedical Microdevices
https://www.readbyqxmd.com/read/29484567/development-of-3d-printed-fibrillar-collagen-scaffold-for-tissue-engineering
#16
Aden Díaz Nocera, Romina Comín, Nancy Alicia Salvatierra, Mariana Paula Cid
Collagen is widely used in tissue engineering because it can be extracted in large quantities, and has excellent biocompatibility, good biodegradability, and weak antigenicity. In the present study, we isolated printable collagen from bovine Achilles tendon and examined the purity of the isolated collagen using sodium dodecyl sulfate polyacrylamide gel electrophoresis. The bands obtained corresponded to α1 , α2 and β chains with little contamination from other small proteins. Furthermore, rheological measurements of collagen dispersions (60 mg per ml of PBS) at pH 7 revealed values of viscosity of 35...
February 27, 2018: Biomedical Microdevices
https://www.readbyqxmd.com/read/29484503/proliferation-of-human-aortic-endothelial-cells-on-nitinol-thin-films-with-varying-hole-sizes
#17
Ming Lun Wu, Mohanchandra K Panduranga, Gregory P Carman
In this paper, we present the effect of micron size holes on proliferation and growth of human aortic endothelial cells (HAECs). Square shaped micron size holes (5, 10, 15, 20 and 25 μm) separated by 10 μm wide struts are fabricated on 5 μm thick sputter deposited Nitinol films. HAECs are seeded onto these micropatterned films and analyzed after 30 days with fluorescence microscopy. Captured images are used to quantify the nucleus packing density, size, and aspect ratio. The films with holes ranging from 10 to 20 μm produce the highest cell packing densities with cell nucleus contained within the hole...
February 27, 2018: Biomedical Microdevices
https://www.readbyqxmd.com/read/29478142/a-practical-approach-for-the-optimization-of-channel-integrity-in-the-sealing-of-shallow-microfluidic-devices-made-from-cyclic-olefin-polymer
#18
Philipp Ganser, Christoph Baum, David Chargin, Alexis F Sauer-Budge, Andre Sharon
A reduced channel height in microfluidic Lab-on-a-Chip (LOC) devices enables a reduction in the required volume of sample and reagents. LOC devices are most often manufactured by microstructuring a planar substrate and subsequently sealing it with a cover film. However, shallow chip designs, made from polymers, are sensitive to channel deformation during the sealing of the microfluidic device. Inappropriate bonding conditions often result in the loss of the microfluidic functionality. A systematic and practical approach for the identification of suitable bonding process parameters is missing...
February 24, 2018: Biomedical Microdevices
https://www.readbyqxmd.com/read/29476424/enhanced-particle-self-ordering-in-a-double-layer-channel
#19
Sheng Yan, Yuxing Li, Qianbin Zhao, Dan Yuan, Guolin Yun, Shi-Yang Tang, Weihua Li
In this work, a novel double-layer microfluidic device for enhancing particle focusing was presented. The double-layer device consists of a channel with expansion-contraction array and periodical slanted grooves. The secondary flows induced by the grooves modulate the flow patterns in the expansion-contraction-array (ECA) channel, further affecting the particle migration. Compared with the single ECA channel, the double-layer channel can focus the particles over a wider range of flow rate. Due to the differentiation of lateral migration, the double-layer channel is able to distinguish the particles with different sizes...
February 23, 2018: Biomedical Microdevices
https://www.readbyqxmd.com/read/29476379/design-and-performance-evaluation-of-collision-protection-based-safety-operation-for-a-haptic-robot-assisted-catheter-operating-system
#20
Linshuai Zhang, Shuxiang Guo, Huadong Yu, Yu Song, Takashi Tamiya, Hideyuki Hirata, Hidenori Ishihara
The robot-assisted catheter system can increase operating distance thus preventing the exposure radiation of the surgeon to X-ray for endovascular catheterization. However, few designs have considered the collision protection between the catheter tip and the vessel wall. This paper presents a novel catheter operating system based on tissue protection to prevent vessel puncture caused by collision. The integrated haptic interface not only allows the operator to feel the real force feedback, but also combines with the newly proposed collision protection mechanism (CPM) to mitigate the collision trauma...
February 23, 2018: Biomedical Microdevices
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