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Biomedical Microdevices

Jacob A M Nuhn, Shenmin Gong, Xiangchen Che, Long Que, Ian C Schneider
The original version of this article unfortunately contained a mistake. One line indicating statistical significance was improperly placed in Fig. 5.
September 18, 2018: Biomedical Microdevices
Feng Liu, Shuibing Wang, Zhigang Lu, Yumei Sun, Chaogang Yang, Qiongwei Zhou, Shaoli Hong, Shengxiang Wang, Bin Xiong, Kan Liu, Nangang Zhang
Isolation and detection of circulating tumor cells (CTCs) has showed a great clinical impact for tumor diagnosis and treatment monitoring. Despite significant progresses of the existing technologies, feasible and cost-effective CTC isolation techniques are more desirable. In this study, a novel method was developed for highly efficient isolation of CTCs from breast cancer patients based on biophysical properties using a pyramid-shaped microchamber. Through optimization tests, the outlet height of 6 μm and the flow rate of 200 μL/min were chosen as the optimal conditions...
September 17, 2018: Biomedical Microdevices
Qian Wu, Xinwei Wei, Yuxiang Pan, Yingchang Zou, Ning Hu, Ping Wang
To perform the drug screening, planar cultured cell models are commonly applied to test efficacy and toxicity of drugs. However, planar cultured cells are different from the human 3D organs or tissues in vivo. To simulate the human 3D organs or tissues, 3D spheroids are developed by culturing a small aggregate of cells which reside around the extracellular matrix and interact with other cells in liquid media. Here we apply lung carcinoma cell lines to engineer the 3D lung cancer spheroid-based biosensor using the interdigitated electrodes for drug efficacy evaluation...
September 15, 2018: Biomedical Microdevices
Yu Zhao, Jozef Brcka, Jacques Faguet, Guigen Zhang
Cell rotation can be achieved by utilizing rotating electric fields through which torques are generated due to phase difference between the dipole moment of cells and the external electric field. While reports of cell rotation under non-rotating electrical fields, such as dielectrophoresis (DEP), are abound, the underlying mechanism is not fully understood. Because of this, contradicting arguments remain regarding if a single cell can rotate under conventional DEP. What's more, the current prevailing DEP theory is not adequate for identifying the cause for such disagreements...
September 8, 2018: Biomedical Microdevices
Jingyun Ma, Na Li, Yachen Wang, Liang Wang, Wenjuan Wei, Liming Shen, Yu Sun, Yang Jiao, Weigong Chen, Jing Liu
3D models of tumours have emerged as an advanced technique in pharmacology and tumour cell biology, in particular for studying malignant tumours such as glioblastoma multiforme (GBM). Herein, we developed a 3D GBM model on a detachably assembled microfluidic device, which could be used to study GBM aggressiveness and for anti-GBM drug testing. Fundamental characteristics of the GBM microenvironment in terms of 3D tissue organisation, extracellular matrices and blood flow were reproduced in vitro by serial manipulations in the integrated microfluidic device, including GBM spheroid self-assembly, embedding in a collagen matrix, and continuous perfusion culture, respectively...
September 6, 2018: Biomedical Microdevices
Tengfei Wang, Guangning Xu, Wenyuan Wu, Xiaoying Wang, Xueliang Chen, Shumin Zhou, Fan You
Nowadays, there is great interest in the use of microfluidic paper-based analytical devices (μPADs) for low-cost diagnostics. In most cases, the test equipment is needed. Here we report a new type of device-independent detection method based on timer-paper-based analytical devices, which can be tested by smartphone, and its application for cholesterol detection. The Quick Response code was designed as the timer component of this device. Wax printing method was employed to print the pattern on filter paper...
September 5, 2018: Biomedical Microdevices
Thiago Coimbra Pimenta, Cátia da Cruz Santos, Ronaldo Luís Thomasini, Lucas Franco Ferreira
Dengue is an infectious viral disease transmitted by the Aedes aegypti mosquito, the control of which is complex. In addition, the clinical diagnosis is difficult to perform since it resembles other febrile infections; thus, the development of more effective methods to detect dengue virus (DV) has drawn increasing attention. The present study aimed to develop an impedimetric immunosensor for dengue diagnosis using a screen-printed electrode (SPE) functionalized with polymer films derived from 4-aminophenylacetic acid (4-APA)...
September 4, 2018: Biomedical Microdevices
Yuxi Sun, Palaniappan Sethu
Density gradient centrifugation exploits density differences between different blood cells to accomplish separation of peripheral blood mononuclear cells (PBMCs) from polymorphonuclear (PNM) cells, and erythrocytes or red blood cells (RBCs). While density gradient centrifugation offers a label-free alternative avoiding the use of harsh lysis buffers for blood cell isolation, it is a time-consuming and labor-intensive process during which blood cells are subject to high-levels of centrifugal force that can artifactually activate cells...
August 28, 2018: Biomedical Microdevices
Jin Guo, Shuxiang Guo, Maoxun Li, Takashi Tamiya
It is challenging to position a catheter or a guidewire within a patient's complicated and delicate vascular structure due to the lack of intuitive visual feedback by only manipulating the proximal part of the surgical instruments. Training is therefore critical before an actual surgery because any mistake due to the surgeon's inexperience can be fatal for the patient. The catheter manipulation skills of experienced surgeons can be useful as input for training novice surgeons. However, few research groups focused on designs with consideration of the contactless catheter motion measurement, which allows obtaining expert surgeons' catheter manipulation trajectories whilst still allowing them to employ an actual catheter and apply conventional pull, push and twist of the catheter as used in bedside intravascular interventional surgeries...
August 22, 2018: Biomedical Microdevices
Ninad Mehendale, Oshin Sharma, Shilpi Pandey, Debjani Paul
Pillar-based passive microfluidic devices combine the advantages of simple designs, small device footprint, and high selectivity for size-based separation of blood cells. Most of these device designs have been validated with dilute blood samples. Handling whole blood in pillar-based devices is extremely challenging due to clogging. The high proportion of cells (particularly red blood cells) in blood, the varying sizes and stiffness of the different blood cells, and the tendency of the cells to aggregate lead to clogging of the pillars within a short period...
August 17, 2018: Biomedical Microdevices
Xianqiang Bao, Shuxiang Guo, Nan Xiao, Youxiang Li, Liwei Shi
Minimally invasive vascular interventional surgery is widely used and remote-controlled vascular interventional surgery robots (RVIRs) are being developed to reduce the occupational risk of the intervening physician in minimally invasive vascular interventional surgeries. Skilled surgeon performs surgeries mainly depending on the detection of collisions. Inaccurate force feedback will be difficult for surgeons to perform surgeries or even results in medical accidents. In addition, the surgeon cannot quickly and easily distinguish whether the proximal force exceeds the safety threshold of blood vessels or not, and thus it results in damage to the blood vessels...
August 16, 2018: Biomedical Microdevices
Benjamin Gorissen, Michael De Volder, Dominiek Reynaerts
In the ever advancing field of minimally invasive surgery, flexible instruments with local degrees of freedom are needed to navigate through the intricate topologies of the human body. Although cable or concentric tube driven solutions have proven their merits in this field, they are inadequate for realizing small bending radii and suffer from friction, which is detrimental when automation is envisioned. Soft robotic actuators with locally actuated degrees of freedom are foreseen to fill in this void, where elastic inflatable actuators are very promising due to their S3-principle, being Small, Soft and Safe...
August 13, 2018: Biomedical Microdevices
Way Lee Cheng, Reza Sadr, Jing Dai, Arum Han
Splitting droplets is becoming a major functional component in increasing number of droplet microfluidic applications, and there is an increasing interest in splitting droplets into two daughter droplets with different volumes. However, designing an asymmetric droplet splitter and predicting how a droplet splits in such designs is not trivial. In this study, numerical simulations were conducted to study droplet breakup in asymmetric T-junctions of square cross-sections having different pressure gradient ratios (i...
August 13, 2018: Biomedical Microdevices
Nelli K Bodiford, Steven J P McInnes, Nicolas H Voelcker, Jeffery L Coffer
This work focuses on an evaluation of novel composites of porous silicon (pSi) with the biocompatible polymer ε-polycaprolactone (PCL) for drug delivery and tissue engineering applications. The degradation behavior of the composites in terms of their morphology along with the effect of pSi on polymer degradation was monitored. PSi particles loaded with the drug camptothecin (CPT) were physically embedded into PCL films formed from electrospun PCL fiber sheets. PSi/PCL composites revealed a release profile of CPT (monitored via fluorescence spectroscopy) in accordance with the Higuchi release model, with significantly lower burst release percentage compared to pSi microparticles alone...
August 10, 2018: Biomedical Microdevices
Lei Zhang, Lihong Sun, Mengmeng Hou, Zhigang Xu, Yuejun Kang, Peng Xue
Temperature is a critical extrinsic physical parameter that determines cell fate. Hyperthermia therapy has become an efficient treatment for tumor ablation. To understand the response of tumor cells under thermal shocks, we present a paper-based photothermal array that can be conveniently coupled with commercial 96-well cell culture plates. This paper chip device was fabricated in one step using Parafilm® and Kimwipers® based on a heat lamination strategy. Liquid was completely adsorbed and confined within the cellulose fibres of hydrophilic regions...
August 9, 2018: Biomedical Microdevices
Chun-Hao Huang, Kin Fong Lei, Ngan-Ming Tsang
The use of electric field for cancer therapy has been proposed for a novel non-invasive cancer therapeutic approach that provides better quality of life for patients. However, argument of the efficacy hampers the therapeutic development for various cancer diseases. More scientific evidences are necessary to be addressed by basic research. The current in vitro cell culture study reports the responses of tumor spheroids after the application of an alternating electric field. Human hepatocarchinoma cells suspended in soft hydrogel were cultured in a cell culture device embedded with stimulating electrodes...
August 9, 2018: Biomedical Microdevices
Chaonan Zhang, Shuxiang Guo, Nan Xiao, Jiaqing Wu, Youxiang Li, Yuhua Jiang
When conducting endovascular interventional surgery, doctors usually experience high viscous resistance resulting from direct contact with blood when operating the guide wire in blood vessels, which reduces the operational efficiency. Improper operation can cause vascular injuries and greatly reduce surgical safety, sometimes leading to the death of the patient. This paper presents a new method that applies transverse microvibrations at the proximal end of a conventional passive guide wire to reduce viscous resistance...
August 9, 2018: Biomedical Microdevices
Jacob Beckham, Faiz Alam, Victor Omojola, Thomas Scherr, Amy Guitreau, Adam Melvin, Daniel S Park, Jin-Woo Choi, Terrence R Tiersch, W Todd Monroe
A microfluidic chip is described that facilitates research and quality control analysis of zebrafish sperm which, due to its miniscule (i.e., 2-5 μl) sample volume and short duration of motility (i.e., <1 min), present a challenge for traditional manual assessment methods. A micromixer molded in polydimethylsiloxane (PDMS) bonded to a glass substrate was used to activate sperm samples by mixing with water, initiated by the user depressing a transfer pipette connected to the chip. Sample flow in the microfluidic viewing chamber was able to be halted within 1 s, allowing for rapid analysis of the sample using established computer-assisted sperm analysis (CASA) methods...
August 9, 2018: Biomedical Microdevices
Atieh Vafajoo, Azin Rostami, Sanam Foroutan Parsa, Reza Salarian, Navid Rabiee, Ghazal Rabiee, Mohammad Rabiee, Mohammadreza Tahriri, Daryoosh Vashaee, Lobat Tayebi, Michael R Hamblin
In recent years, there has been growing interest in optically-encoded or tagged functionalized microbeads as a solid support platform to capture proteins or nucleotides which may serve as biomarkers of various diseases. Multiplexing technologies (suspension array or planar array) based on optically encoded microspheres have made possible the observation of relatively minor changes in biomarkers related to specific diseases. The ability to identify these changes at an early stage may allow the diagnosis of serious diseases (e...
August 7, 2018: Biomedical Microdevices
Anurup Ganguli, Gelson J Pagan-Diaz, Lauren Grant, Caroline Cvetkovic, Mathew Bramlet, John Vozenilek, Thenkurussi Kesavadas, Rashid Bashir
Surgeons typically rely on their past training and experiences as well as visual aids from medical imaging techniques such as magnetic resonance imaging (MRI) or computed tomography (CT) for the planning of surgical processes. Often, due to the anatomical complexity of the surgery site, two dimensional or virtual images are not sufficient to successfully convey the structural details. For such scenarios, a 3D printed model of the patient's anatomy enables personalized preoperative planning. This paper reviews critical aspects of 3D printing for preoperative planning and surgical training, starting with an overview of the process-flow and 3D printing techniques, followed by their applications spanning across multiple organ systems in the human body...
August 4, 2018: Biomedical Microdevices
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