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Gastric Cancer

Kentaro Sugano
BACKGROUND: Helicobacter pylori (H. pylori) is considered to be the most important risk factor for gastric cancer (GC). The International Agency for Research on Cancer reported that H. pylori eradication could reduce the risk of developing GC. Several clinical studies have investigated this relationship as well; however, their results are inconsistent owing to the varied inclusion criteria. To address the effect of H. pylori eradication on GC incidence, we conducted a comprehensive meta-analysis with several subgroup analyses to resolve these inconsistencies...
September 11, 2018: Gastric Cancer
Toru Aoyama, Takaki Yoshikawa, Tsutomu Sato, Tsutomu Hayashi, Takanobu Yamada, Takashi Ogata, Haruhiko Cho
BACKGROUND: Laparoscopy-assisted distal gastrectomy (LADG) has an advantage of earlier recovery after surgery due to having lower invasiveness and wound pain than open distal gastrectomy (ODG). However, whether the same enhanced recovery after surgery (ERAS) program for LADG is equally feasible and safe for ODG remains unclear. METHODS: We retrospectively extracted the clinical data of the patients enrolled in JCOG0912 from the medical record system of our hospital and compared the treatment process and short-term surgical outcomes between LADG and ODG...
September 7, 2018: Gastric Cancer
Atsushi Shiozaki, Yosuke Ariyoshi, Daisuke Iitaka, Toshiyuki Kosuga, Hiroki Shimizu, Michihiro Kudou, Tomoki Konishi, Katsutoshi Shoda, Tomohiro Arita, Hirotaka Konishi, Shuhei Komatsu, Takeshi Kubota, Hitoshi Fujiwara, Kazuma Okamoto, Mitsuo Kishimoto, Eiichi Konishi, Yoshinori Marunaka, Daisuke Ichikawa, Eigo Otsuji
BACKGROUND: Recent studies have described important roles for the sodium iodide symporter (NIS) in tumor behavior. The objectives of the present study were to investigate the role of NIS in the regulation of genes involved in tumor progression and the clinicopathological significance of its expression in gastric cancer (GC). METHODS: In human GC cell lines, knockdown experiments were conducted using NIS siRNA, and the effects on proliferation, survival, and cellular movement were analyzed...
September 6, 2018: Gastric Cancer
Jing Yan, Bing Yang, Shuye Lin, Rui Xing, Youyong Lu
BACKGROUND: Recurrence is a primary cause of gastric cancer (GC)-related deaths. We reported previously that low expression of miR-142-5p could predict recurrence in GC. The present study aimed to investigate the function and mechanism of miR-142-5p in metastasis of GC. METHODS: MiR-142-5p expression was detected in 101 GC samples by qRT-PCR. Its clinical significance was statistically analyzed. The roles of miR-142-5p and its candidate target gene CYR61 in metastasis were determined both in vivo and in vitro...
September 3, 2018: Gastric Cancer
Tadanobu Nagaya, Shuhei Okuyama, Fusa Ogata, Yasuhiro Maruoka, Peter L Choyke, Hisataka Kobayashi
BACKGROUND: Peritoneal dissemination (PD) of abdominal malignancies is a common form of metastasis and its presence signals a poor prognosis. New treatment is required for patients with PD. Near infrared photoimmunotherapy (NIR-PIT) is a highly selective tumor treatment that employs an antibody-photo-absorber conjugate (APC). In this study, we investigate in vitro and in vivo efficacy of trastuzumab (tra)-IR700DX NIR-PIT on a human epidermal growth factor receptor type 2 (HER2)-positive gastric cancer cell line...
August 31, 2018: Gastric Cancer
C Mariette, F Carneiro, H I Grabsch, R S van der Post, W Allum, Giovanni de Manzoni
BACKGROUND AND AIMS: Clinicopathological characteristics of gastric cancer (GC) are changing, especially in the West with a decreasing incidence of distal, intestinal-type tumours and the corresponding increasing proportion of tumours with Laurén diffuse or WHO poorly cohesive (PC) including signet ring cell (SRC) histology. To accurately assess the behaviour and the prognosis of these GC subtypes, the standardization of pathological definitions is needed. METHODS: A multidisciplinary expert team belonging to the European Chapter of International Gastric Cancer Association (IGCA) identified 11 topics on pathological classifications used for PC and SRC GC...
August 25, 2018: Gastric Cancer
Hadi Maleki Kakelar, Abolfazl Barzegari, Jaber Dehghani, Shahram Hanifian, Nazli Saeedi, Jaleh Barar, Yadollah Omidi
Helicobacter pylori affect around 50% of the population worldwide. More importantly, the gastric infection induced by this bacterium is deemed to be associated with the progression of distal gastric carcinoma and gastric mucosal lymphoma in the human. H. pylori infection and its prevalent genotype significantly differ across various geographical regions. Based on numerous virulence factors, H. pylori can target different cellular proteins to modulate the variety of inflammatory responses and initiate numerous "hits" on the gastric mucosa...
August 25, 2018: Gastric Cancer
Jessica L Mueller, Danbee H Kim, Sahael Stapleton, Christy E Cauley, David C Chang, Cho Hyun Park, Kyo Young Song, John T Mullen
BACKGROUND: The prognosis of gastric cancer patients is better in Asia than in the West. Genetic, environmental, and treatment factors have all been implicated. We sought to explore the extent to which the place of birth and the place of treatment influences survival outcomes in Korean and US patients with localized gastric cancer. METHODS: Patients with localized gastric adenocarcinoma undergoing potentially curative gastrectomy from 1989 to 2010 were identified from the SEER registry and two single institution databases from the US and Korea...
August 22, 2018: Gastric Cancer
Han Hong Lee, Su Young Kim, Eun Sun Jung, Jinseon Yoo, Tae-Min Kim
BACKGROUND: The acquisition of an invasive phenotype by a tumor cell is a crucial step of malignant transformation. The underlying genetic mechanisms in gastric cancer (GC) are not well understood. METHODS: We performed whole-exome sequencing of 15 pairs of primary GC and their matched lymph node (LN) metastases (10 primary GCs with single matched LNs and 5 primary GCs with three LNs per case, respectively). Somatic alterations including single nucleotide variations, short insertions/deletions including locus-level microsatellite instability and copy number alterations were identified and compared between the primary and metastatic LN genomes...
August 21, 2018: Gastric Cancer
Woo Jin Hyung, Han-Kwang Yang, Sang-Uk Han, Young-Jun Lee, Joong-Min Park, Jin Jo Kim, Oh Kyung Kwon, Seong Ho Kong, Hyoung-Il Kim, Hyuk-Joon Lee, Wook Kim, Seung Wan Ryu, Sung-Ho Jin, Sung Jin Oh, Keun Won Ryu, Min-Chan Kim, Hye-Seong Ahn, Young Kyu Park, Young-Ho Kim, Sun-Hwi Hwang, Jong Won Kim, Gyu Seok Cho
BACKGROUND: With improved short-term surgical outcomes, laparoscopic distal gastrectomy has rapidly gained popularity. However, the safety and feasibility of laparoscopic total gastrectomy (LTG) has not yet been proven due to the difficulty of the technique. This single-arm prospective multi-center study was conducted to evaluate the use of LTG for clinical stage I gastric cancer. METHODS: Between October 2012 and January 2014, 170 patients with pathologically proven, clinical stage I gastric adenocarcinoma located at the proximal stomach were enrolled...
August 20, 2018: Gastric Cancer
Jintuan Huang, Yi Sun, Hao Chen, Yi Liao, Senmao Li, Chunyu Chen, Zuli Yang
BACKGROUND: ADAMTS5 has been reported to be involved in the progression of several human tumors. Nevertheless, the role of ADAMTS5 in gastric cancer (GC) remains poorly defined. METHODS: ADAMTS5 expression levels were analyzed by quantitative real-time PCR (qRT-PCR) and immunohistochemistry (IHC) in GC cell lines and tissues, and the correlations between ADAMTS5 expression and clinicopathological features and survival were also examined. In vitro assays, including transwell assays, wound healing assays and cell adhesion assays, were employed to further explore the biological functions of ADAMTS5...
August 13, 2018: Gastric Cancer
Junya Aoyama, Hirofumi Kawakubo, Osamu Goto, Tadaki Nakahara, Shuhei Mayanagi, Kazumasa Fukuda, Koichi Suda, Rieko Nakamura, Norihito Wada, Hiroya Takeuchi, Yuko Kitagawa
BACKGROUND: Based on the sentinel node (SN) concept, function-preserving surgery with SN basin dissection (SNBD) can be performed for SN-negative early gastric cancers. Particularly, a resection area can be minimized when the SN basin and primary site are closely localized. The aim of this study was to compare probabilities of being candidates for local resection with SNBD based on tumor location among patients with early gastric cancer. METHODS: We retrospectively analyzed 358 patients who underwent surgery with SN mapping for gastric cancer in our institution from November 1999 to April 2014...
August 11, 2018: Gastric Cancer
Tomio Arai, Yoko Matsuda, Junko Aida, Kaiyo Takubo, Toshiyuki Ishiwata
BACKGROUND: Despite predominant microsatellite instability (MSI) in intestinal-type gastric carcinomas, we found the most frequent MSI in solid-type poorly differentiated adenocarcinoma (PDA). Although this tumor is classified as PDA, it is hypothesized to possess peculiar features among PDAs. The present study aimed to clarify the clinicopathological and molecular characteristics of this tumor. METHODS: We examined the expression of p53, mismatch-repair proteins, and mucin core glycoproteins; microsatellite status; and mutations in KRAS and BRAF, as well as clinicopathological features, in 54 cases of PDA of the stomach (31 solid-type PDAs and 23 non-solid-type PDAs)...
August 7, 2018: Gastric Cancer
Jun Kinoshita, Sachio Fushida, Masahide Kaji, Katsunobu Oyama, Daisuke Fujimoto, Yasuo Hirono, Tomoya Tsukada, Takashi Fujimura, Shigekazu Ohyama, Kazuhisa Yabushita, Naotaka Kadoya, Koji Nishijima, Tetsuo Ohta
BACKGROUND: Acetaminophen is used in multimodal therapy for postoperative pain management. However, the additional effects of acetaminophen in combination with thoracic epidural analgesia (TEA) are not well understood. This prospective, multicenter randomized study was conducted to evaluate the efficacy of routine intravenous (i.v.) acetaminophen in combination with TEA for the management of postoperative pain in gastric cancer surgery. METHODS: A total of 120 patients who underwent distal gastrectomy were randomly assigned in a 1:1 ratio to receive i...
August 7, 2018: Gastric Cancer
Sebastian Mondaca, Matthew Margolis, Francisco Sanchez-Vega, Philip Jonsson, Jamie C Riches, Geoffrey Y Ku, Jaclyn F Hechtman, Yaelle Tuvy, Michael F Berger, Manish A Shah, David P Kelsen, David H Ilson, Kenneth Yu, Zoe Goldberg, Andrew S Epstein, Avni Desai, Vincent Chung, Joanne F Chou, Marinela Capanu, David B Solit, Nikolaus Schultz, Yelena Y Janjigian
BACKGROUND: Trastuzumab with cisplatin and fluoropyrimidine is the standard treatment in metastatic HER2-positive gastric or gastroesophageal (GE) junction adenocarcinoma; however, there is limited data on the efficacy of trastuzumab in combination with a three-drug regimen in this setting. We examined the efficacy and safety of modified docetaxel, cisplatin and 5 fluorouracil (mDCF) plus trastuzumab in a single-arm multicenter phase II trial. METHODS: Previously untreated patients with HER2-positive metastatic gastric or GE junction adenocarcinoma were treated with mDCF and trastuzumab every 2 weeks...
August 7, 2018: Gastric Cancer
Yi-Chu Kao, Wen-Liang Fang, Ruei-Fang Wang, Anna Fen-Yau Li, Muh-Hwa Yang, Chew-Wun Wu, Yi-Ming Shyr, Kuo-Hung Huang
BACKGROUND: Signet ring cell adenocarcinoma is a histological classification based on the WHO classification. The presence of this specific histological type is associated with a worse pathological appearance. The prognosis of signet ring cell adenocarcinoma in gastric cancer patients after curative surgery is still under debate. METHODS: From January 1988 to December 2012, a total of 2971 patients, including 819 early and 2152 advanced gastric cancer patients underwent curative resection for gastric cancer...
August 1, 2018: Gastric Cancer
Tanis D Godwin, S Thomas Kelly, Tom P Brew, Nicola M Bougen-Zhukov, Andrew B Single, Augustine Chen, Cassie E Stylianou, Lawrence D Harris, Sophie K Currie, Bryony J Telford, Henry G Beetham, Gary B Evans, Michael A Black, Parry J Guilford
BACKGROUND: The E-cadherin gene (CDH1) is frequently mutated in diffuse gastric cancer and lobular breast cancer, and germline mutations predispose to the cancer syndrome Hereditary Diffuse Gastric Cancer. We are taking a synthetic lethal approach to identify druggable vulnerabilities in CDH1-mutant cancers. METHODS: Density distributions of cell viability data from a genome-wide RNAi screen of isogenic MCF10A and MCF10A-CDH1-/- cells were used to identify protein classes affected by CDH1 mutation...
July 31, 2018: Gastric Cancer
Antoni Szczepanik, Marek Sierzega, Grażyna Drabik, Anna Pituch-Noworolska, Piotr Kołodziejczyk, Marek Zembala
BACKGROUND: The phenotypic heterogeneity of circulating tumor cells (CTC) in peripheral blood and disseminated tumor cells (DTC) in bone marrow is an important constraint for clinical decision making. Here, we investigated the implications of two different subpopulations of these cells in gastric cancer (GC). METHODS: GC patients (n = 228) who underwent elective gastric resections were prospectively examined for CTC/DTC. The cells obtained from peripheral blood and bone marrow aspirates were sorted by flow cytometry and CD45- cells expressing cytokeratins (8, 18, and 19) and CD44 were identified by immunofluorescent double staining...
July 28, 2018: Gastric Cancer
Tae-Se Kim, Byung-Hoon Min, Kyoung-Mee Kim, Jun Haeng Lee, Poong-Lyul Rhee, Jae J Kim
BACKGROUND: The previous studies demonstrated aggressive clinicopathologic features of papillary early gastric cancer (EGC). This raised concerns about the appropriateness of current Japanese guidelines that recommend the same endoscopic submucosal dissection (ESD) criteria for papillary EGC as for well-differentiated (WD) or moderately differentiated (MD) EGCs. METHODS: This study included 4140 patients who underwent ESD for differentiated-type EGC (87 papillary EGCs and 4259 WD or MD EGCs)...
July 23, 2018: Gastric Cancer
Raito Asaoka, Taiichi Kawamura, Rie Makuuchi, Tomoyuki Irino, Yutaka Tanizawa, Etsuro Bando, Masanori Terashima
BACKGROUND: Hospital readmission is gathering greater attention as a measure of health care quality. The introduction of fast-track surgery has led to shorter lengths of hospitalization without increasing the risk of postoperative complications and readmission. The collection of comprehensive readmission data is essential for the further improvement of patient care. The aim of the present study is to evaluate the risk factors for readmission within 30 days of discharge after gastrectomy...
July 13, 2018: Gastric Cancer
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