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Nuclear Medicine Review. Central & Eastern Europe

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https://www.readbyqxmd.com/read/27813617/semi-quantitative-method-for-the-assessment-of-focal-lesions-in-parathyroid-scintigraphy-with-relation-to-histopathology-a-prospective-study
#1
Maria Henryka Listewnik, Hanna Piwowarska-Bilska, Mirela Kurantowicz, Marek Ostrowski, Andrzej Borowiecki, Krzysztof Safranow, Krystyna Jasiakiewicz, Jacek Iwanowski, Maria Chosia, Maria Laszczyńska, Bożena Birkenfeld
BACKGROUND: The aim of this paper was to analyse our own semi-quantitative method of assessing focal lesions localised in pre-operative diagnostic scintigraphy of primary hyperparathyroidism (PHPT) using 99mTc-MIBI with washout and comparing these data with the result of the histopathological examination (HP). MATERIAL AND METHODS: A total of 40 (37 female, 3 male, average age 58.7 years) patients with a suspicion of PHPT were enrolled for prospective analysis. Dual phase planar and SPECT/CT examination with 99mTc-MIBI were performed...
November 4, 2016: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/27900759/torsion-of-the-undescended-testis-detected-by-99mtc-testicular-scintigraphy-a-case-report
#2
Hamed Shayegani, Ghasemali Divband, Mahmoud Tavakkoli, Maliheh Banihasan, Ramin Sadeghi
We reported a case of torsion of the undescended testis in a 9-month-old boy which was diagnosed with 99mTc testicular scin-tigraphy. The scan showed diffuse increased activity in the location of the undescended testis and no photopenic area was visible. At surgery, torsion of the undescended testis was detected and fixed.
2016: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/27900758/99mtc-hmpao-perfusion-spect-ct-in-the-diagnosis-of-brain-death
#3
Thorsten Derlin, Desiree Weiberg
This report describes a case of brain death (BD) evaluated by 99mTc-hexamethylpropylene amine oxime (HMPAO) single photon emission tomography/computed tomography (SPECT/CT). A 16-year-old boy with a history of rapid unexpected brain herniation due to pilocytic astrocytoma underwent 99mTc-HMPAO SPECT/CT for evaluation of brain death in the context of organ donation. Flow images demonstrated lack of blood flow to the brain, and delayed images showed absence of demonstrable radionuclide activity within the brain...
2016: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/27900757/unsuspected-axillary-lymph-node-metastasis-of-nasopharyngeal-and-cervical-cancer-on-18fdg-pet-ct-a-case-report
#4
Sungmin Kang
Axillary lymph node metastasis (ALNM) from cancer except breast cancer is rare. Whole body 18F-Fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) that simultaneously offers anatomic and metabolic information is widely used and has become an effective modality in many clinical fields, especially oncology, and also may detect an unexpected metastasis. We report two cases of ALMN of nasopharyngeal and cervical cancer that was detected on whole body PET/CT.
2016: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/27900756/a-rare-case-of-medullary-carcinoma-thyroid-metastasizing-to-bilateral-breast-parenchyma
#5
Aamna Hassan, Maimoona Siddiqui, Sidra Jahangir
Medullary carcinoma of the thyroid (MTC) commonly spreads through the lymphatics to distant sites such as lung, liver and bone. Spread to the breast is rare. We report a case of metastatic MTC which progressed to develop nodal metastases to cer-vical and mediastinal regions, visceral metastases to the liver, lung and ultimately to bilateral breasts. Clinically it is important to distinguish metastatic breast lesions from primary breast cancer as each is managed differently. Both cytological and radio-logical investigations were done followed by excision biopsy...
2016: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/27900755/incidental-18f-fdg-pet-ct-bilateral-breast-uptake-due-to-carcinoma
#6
Domenico Albano, Mattia Bertoli, Maria Laura Morassi, Giovanni Bosio, Emanuela Orlando, Francesco Bertagna
We report a case of 71-year-old female patient, previously treated with chemotherapy and surgical resection of sigmoid tract of the large bowel for adenocarcinoma (pT3N1M0), who underwent a 18F-FDG PET/CT for a suspicious hepatic lesion detected at CT scan during follow-up. 18F-FDG PET/CT showed no abnormal uptake in the liver both at 60 minutes and 120 minutes after injection but revealed a pathological uptake in two breast nodules, (one localized in upper-internal-quadrant of the right breast and the other in the upper-external-quadrant of the left breast)...
2016: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/27813622/18f-fdg-pet-ct-in-the-diagnosis-of-an-extranodal-relapse-of-diffuse-large-b-cell-lymphoma-dlbcl-a-clinical-case-with-a-literature-review
#7
Borislav Chaushev, Ilina Micheva, Merilin Mechmed, Boyan Balev, Yana Bocheva, Darina Ivanova, Ivan Krasnaliev, Rumena Lozanova, Anelia Klisarova, Pavel Bochev, Jivka Dancheva
Extranodal lymphoma, secondary to or accompanying nodal disease is uncommon, but not unusual finding. 18-Fluorodeoxyglucose positron emission tomography (18F-FDG PET/CT) imaging has an essential role in the staging of lymphoma, in treatment response monitoring, and in detection of recurrence. We present a case of a 52-year-old man with generalized diffuse large B-cell lymphoma (DLBCL) with multiple extranodal sites involvement detected by 18F-FDG PET/CT. With this clinical case we demonstrate that 18F-FDG PET-CT is a more effective technique than CE-CT for the evaluation of viable extranodal involvement of the diffuse large B-cell lymphoma (DLBCL) and should be combined in the monitoring of DLBCL...
2016: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/27813621/incidental-thyroid-99mtc-mdp-uptake-in-a-patient-affected-by-differentiated-thyroid-cancer
#8
Domenico Albano, Gian Carlo Magri, Giorgio Treglia, Francesco Bertagna
We report a case of incidental uptake of 99mTc-methylene diphosphonate in the thyroid in a 62-year-old female with a history of breast cancer treated with quadrantectomy, chemotherapy and radiotherapy, who underwent total-body-bone scintigraphy during follow up. Planar scintigraphy was followed by neck SPECT-CT that demonstrated an area of increased tracer uptake in the neck at the left lobe of the thyroid. Neck ultrasonography showed a nodule corresponding to SPECT-CT finding and the ultrasound-guided fine needle aspiration documented the presence of papillary carcinoma...
2016: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/27813620/occult-breast-primary-malignancy-presenting-as-isolated-axillary-lymph-node-metastasis-early-detection-of-primary-site-by-18f-fdg-pet-ct
#9
Ramya Soundararajan, Niraj Naswa, Sellam Karunanithi, Ritika Walia, Rakesh Kumar, Chandrasekhar Bal
Breast cancer patients rarely present with isolated axillary lymph node metastasis without any clinical or radiological evidence of primary tumor. Identification of the primary site of tumor helps in planning appropriate patient management which has definite impact on patient's survival. We present here a case of 30-year-old female who presented with isolated right axillary lymph node metastasis with no evidence of primary tumor clinically. Conventional imaging modalities were negative for primary site. She underwent whole body 18F-Flurodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) and it contributed significantly in early detection of occult primary tumor in right breast...
2016: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/27813619/extradural-ganglioneuroma-with-t1-t2-involvement-mimicking-spondylodiscitis-a-case-report-and-a-review-of-the-literature
#10
Mehdi Mogharrabi, Ramin Azarhoush, Hamid Javadi, Elahe Pirayesh, Majid Assadi
Ganglioneuroma (GN) is a rare benign neural tumor, usually derived from the ganglia of the sympathetic system. This report describes a 36-year-old man who presented with back pain and local tenderness that closely mimicked the clinical and ima-ging findings of spondylodiskitis. However, histologic examination made the diagnosis of GN. To our knowledge, this is the first report presenting the pattern of a GN as a differential diagnosis of spondylodiskitis.
2016: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/27813618/editorial
#11
Grzegorz Kamiński
I would like to announce the special supplement of "Nuclear Medicine Review" which consists of case reports only.
2016: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/27813616/is-sentinel-node-mapping-possible-in-surgically-removed-ectopic-axillary-breast-cancer-a-case-report
#12
Royasadat Alavifard, Sima Kadkhodayan, Fatemeh Homaee Shandiz, Vahid Reza Dabbagh, Ramin Sadeghi
We reported a 24-year-old female patient with the history of ectopic axillary breast cancer which was removed surgically. Sentinel node mapping was performed for lymphatic axillary staging of this patient with two injections of the 99m-Tc-phytate in both ends of the surgical scar. Lymphoscintigraphy showed an axillary sentinel node which was harvested during surgery and was not pathologically involved. Our case showed that sentinel node mapping is possible for ectopic axillary breast cancer patients even after excisional biopsy of the index lesion...
2016: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/27813615/18f-fdg-pet-ct-demonstrated-renal-and-hepatic-cyst-infection-in-a-patient-with-autosomal-dominant-polycystic-kidney-disease
#13
Domenico Albano, Giovanni Bosio, Francesco Bertagna
Infection of renal or hepatic cyst is a serious complication of autosomal dominant polycystic kidney disease (ADPKD) and early diagnosis is crucial for the correct management. We report a case of 64-year-old male with ADPKD, who required renal transplantation some years before, with recent recurrent episodes of fever and abdominal pain, who underwent 18F-FDG PET/CT twice at 18 months intervals, after not conclusive conventional imaging studies (CT, ultrasonography). 18F-FDG PET/CT has proven to be a useful method for the diagnosis of renal and hepatic cyst infection in a patient with ADPKD and for the subse-quent management...
2016: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/27479887/limitations-and-pitfalls-of-99mtc-edda-hynic-toc-tektrotyd-scintigraphy
#14
Ildikó Garai, Sandor Barna, Gabor Nagy, Attila Forgacs
Tektrotyd kit was developed by Polatom company for 99mTc labeling to make an alternative tracer of somatostatin receptor scintigraphy available. Since 2005, 99mTc-EDDA/HYNIC-Tyr3-Octreotide has been used in clinical imaging and achieved high impact in management of patients with neuroendocrine tumors. Knowing the limitations and pitfalls is essential to provide ac-curate diagnosis. Therefore, the potential pitfalls associated with the use of 99mTc-EDDA/HYNIC-TOC are reviewed on the basis of own experience. Data were analyzed of 310 patients who underwent somatostatin receptor scintigraphy with 99mTc-Tektrotyd...
2016: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/27479886/influence-of-pet-ct-68ga-somatostatin-receptor-imaging-on-proceeding-with-patients-who-were-previously-diagnosed-with-99mtc-edda-hynic-toc-spect
#15
Dorota Madrzak, Renata Mikołajczak, Grzegorz Kamiński
BACKGROUND: The aim of this study was the assessment of utility of somatostatin receptor scintigraphy (SRS) by SPECT imaging using 99mTc-EDDA/HYNIC-Tyr3-octreotide (99mTc-EDDA/HYNIC-TOC) in patients with neuroendocrine neoplasm (NEN) or suspected NEN, referred to Nuclear Medicine Dept. of Voivodship Specialty Center in Rzeszow. The selected group of patients was referred also to 68Ga PET/CT. The posed question was the ratio of patients for whom PET/CT with 68Ga would change their management...
2016: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/27479885/clinical-application-of-spect-ct-with-99mtc-tektrotyd-in-bronchial-and-thymic-neuroendocrine-tumors-nets
#16
Sonya Sergieva, Bozhil Robev, Milena Dimcheva, Albena Fakirova, Radka Hristoskova
Neuroendocrine tumors (NETs) of the thorax including bronchial and thymic tumors belong to foregut NETs. Limited loco-regional thoracic NETs can be resected with surgery, but in extensive metastatic disease the treatment is mainly palliative. A high incidence and density of somatostatin receptors (SSTR2, SSTR3, and SSTR5) are found in thoracic NETs. The purpose of this study was to evaluate the role of SPECT-CT somatostatin receptor scintigraphy (SRS) with 99mTc-Tektrotyd for imaging, staging and follow up of patients with bronchial and thymic neuroendocrine tumors...
2016: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/27479884/99mtc-edda-hynic-toc-in-management-of-patients-with-head-and-neck-somatostatin-receptor-positive-tumors
#17
Mate Trogrlic, Stanko Tezak
BACKGROUND: Aim of this study was to determine the value of technetium-99m-hydrazinonicotinyl-Tyr3-octreotide (99mTc-ED-DA/HYNIC-TOC) in patients with somatostatin receptor (SSR) positive tumors of head and neck region. MATERIAL AND METHODS: A total number of 16 patients were enrolled in this study. Planar whole body (WB) and single photon emission computed tomography (SPECT) images were acquired at 2 and 4 hours after the injection of approximately 670 MBq of 99mTc-EDDA/HYNIC-TOC...
2016: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/27479883/99mtc-edda-hynic-toc-in-the-diagnosis-of-differentiated-thyroid-carcinoma-refractory-to-radioiodine-treatment
#18
Rafał Czepczyński, Maria Gryczyńska, Marek Ruchała
BACKGROUND: In majority of cases of differentiated thyroid carcinoma (DTC), the ablative radioiodine treatment shows high efficacy. In a small number of patients, mechanism of selective iodine uptake by the DTC cells is insufficient and alternative methods of diagnosis and treatment are needed. As demonstrated in vitro, DTC cells show expression of somatostatin recep-tors. Radiolabeled somatostatin analogs are widely used in the diagnosis of neuroendocrine tumors. The aim of the study was to evaluate the utility of peptide receptor scintigraphy with the use of 99mTc-EDDA/HYNIC-TOC in the diagnosis of DTC in patients with elevated thyroglobulin concentrations (Tg), negative WBS and no effect of the consecutive radioiodine therapies...
2016: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/27479790/radiopharmaceuticals-for-somatostatin-receptor-imaging
#19
Renata Mikołajczak, Helmut R Maecke
The aim of this review is to summarize the developments and briefly characterize the somatostatin analogs which are currently used for somatostatin receptor imaging in clinical routine or in early phase clinical trials. Somatostatin (sst) receptor targeting with radiolabeled peptides has become an integral part in nuclear oncology during the last 20 years. This integration process has been initiated in Europe with the introduction to the market of 111In-DTPA-DPhe1-octreotide [111In-pentetreotide]. Introducing 99mTc in somatostatin receptor targeting radiopeptides resulted in much better image quality, higher sensitivity of tumor detection and lower mean effective dose for the examined patient...
2016: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/27479789/nen-the-role-of-somatostatin-receptor-scintigraphy-in-clinical-setting
#20
Marta Opalińska, Alicja Hubalewska-Dydejczyk, Anna Sowa-Staszczak, Agnieszka Stefańska
Detection of neuroendocrine neoplasms (NENs) and monitoring of their response to therapy is still challenging due to huge heterogeneity of that group of tumors. Actually, NENs visualization is mainly based on molecular imaging while in the past it was relied on less effective structural imaging including CT and MRI. Molecular imaging techniques in combination with structural imaging (hybrid imaging), especially in patients with well-differentiated NENs, in addition to morphological provide the functional information about tumor which benefits in a more accurate patient management, including more sensitive visualization of primary tumors, more precise staging and better therapy follow-up...
2016: Nuclear Medicine Review. Central & Eastern Europe
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