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Pediatrics International: Official Journal of the Japan Pediatric Society

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https://www.readbyqxmd.com/read/27914210/randomized-controlled-trial-of-oral-immunotherapy-for-egg-allergy-in-japanese-patients
#1
Masayuki Akashi, Hiroki Yasudo, Masami Narita, Ichiro Nomura, Akira Akasawa, Motohiro Ebisawa, Takao Takahashi, Yukihiro Ohya
BACKGROUND: Egg allergy is one of the most common food allergies in young child. While oral immunotherapy (OIT) is not routinely recommended in current guidelines, it has been considered as a potential alternative treatment strategy. Studies on OIT for food allergies have been explored; however, no studies with control group have been reported in Japan. METHODS: The first oral food challenge test (OFC) was performed on participants before treatment to ensure the diagnosis and evaluate the threshold dose for egg by the way of double-blind, placebo-controlled food challenge (DBPCFC)...
December 3, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27914182/positive-feelings-during-pregnancy-early-feeding-practices-and-infant-health
#2
Melissa A McManus, Ali A Khalessi, Joyce Lin, Jahanzeb Ashraf, Stephanie M Reich
BACKGROUND: Early parenting practices, like infant feeding, can impact children's physical health. Additionally, negative prenatal maternal affect can influence feeding choices, like breastfeeding, and can have a detrimental effect on children's health. However, little is known about the contribution of positive maternal affect during pregnancy on feeding practices and children's health. METHOD: This study explored whether positive prenatal feelings influenced children's health during the first 18 months, and whether early feeding practices mediated the relationship between these two variables...
December 3, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27880031/increased-levels-of-plasma-soluble-human-leukocyte-antigen-g-in-persistent-wheezy-infants
#3
Fulya Tahan, Hatice Eke Gungor, Himmet Haluk Akar, Berkay Saraymen
BACKGROUND: Human leukocyte antigen (HLA)-G is a non-classical major histocompatibility complex (MHC) class I antigen characterized by limited polymorphism in its coding region, unique tissue expression pattern in physiologic conditions and immunomodulatory properties. Recently, many studies suggest that the levels of sHLA-G were higher in atopic asthma and allergic rhinitis (AR). However, this remains to be uncertain in wheezy infants. In the present study, it was aimed to determine sHLA-G levels in wheezy infants...
November 23, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27875021/lifestyle-and-bowel-movements-in-school-children-results-from-the-toyama-birth-cohort-study
#4
Masaaki Yamada, Michikazu Sekine, Takashi Tatsuse
BACKGROUND: Constipation is prevalent health disorder and it has been bothering many pediatricians as well as people suffering from constipation. There have been few epidemiological surveys about constipation in Japanese children. This study aims to evaluate the prevalence of non-daily bowel movements (BM) and irregular BM among children and to identify modifiable lifestyle factors relevant to their bowel habits. METHODS: Subjects were from the Toyama Birth Cohort Study in Japan...
November 22, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27859985/leptomeningeal-dissemination-and-vertebral-bone-involvement-in-a-child-with-pilocytic-astrocytoma
#5
Metin Demirkaya, Betül Sevinir, Salih Güler, Candan Demiröz, Özgür Taskapilioglu, Selcuk Yilmazlar, Figen Palabiyik, Sahsine Tolunay
In low-grade glioma, metastasis is rarely seen. Few cases of leptomeningeal dissemination have been reported in children. Vertebral bone metastasis has not been reported so far. Herein is described the case of a pediatric patient with the diagnosis of pilocytic astrocytoma, and leptomeningeal dissemination detected at the time of diagnosis, who then received radiotherapy and chemotherapy upon development of vertebral bone metastasis during treatment.
November 13, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27862707/pharmacotherapy-in-patients-with-pediatric-cipo-a-nationwide-survey-in-japan
#6
Naoki Hashizume, Minoru Yagi, Kosuke Ushijima, Yoshitaka Seki, Suguru Fukahori, Mitsuru Muto, Hiroshi Matsufuji, Tomoaki Taguchi
PURPOSE: Chronic intestinal pseudo-obstruction (CIPO) is a rare disabling and life-threatening disorder characterized by a severe impairment of gastrointestinal peristalsis. With respect to pharmacotherapy, while a number of agents have been developed, only a few trials have attempted to improve the pathological condition of patients with CIPO. This report presents the actual findings of pharmacotherapy in the patients with pediatric CIPO from the view point of a nationwide survey on the actual situation in Japan...
November 12, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27862704/what-happens-to-children-who-move-off-the-autism-spectrum-a-clinical-follow-up-study
#7
Nahit Motavalli Mukaddes, Tuba Mutluer, Basak Ayik, Ayla Umut
OBJECTIVES: There is controversial information on school age outcome of individuals who lose the diagnosis of autism and achieve "optimal outcome" (OO). The present study aimed to assess the autism symptoms and other psychiatric disorders in a group of children with a past history of autism. METHODS: The study includes individuals (n=26) who lost the diagnosis of autism two to eight years previously. Clinical assessment was done with both parents and children. DSM-V criteria were used for diagnosis of ASD...
November 12, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27862664/-neonatal-outcomes-in-a-level-ii-regional-neonatal-intensive-care-unit
#8
Raid M R Umran, Asjad Al-Jammali
BACKGROUND: Improving the neonatal mortality is a challenge in developing countries like Iraq. Increasing demands and overload of maternity services can considerably limit the improvement in neonatal outcomes. We aimed to document the numbers, disease patterns and outcomes of admitted newborns and the improvement after implementing clinical protocols and to identify possible future target measures. METHOD: A descriptive study was conducted at neonatal intensive care unit (NICU) at a regional hospital from 2011 to 2013...
November 12, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27809389/epidemiology-clinical-characteristics-and-genetic-etiology-of-neonatal-diabetes-in-japan
#9
Kazuaki Nagashima, Daisuke Tanaka, Nobuya Inagaki
Neonatal diabetes mellitus (NDM) is a rare but potentially devastating metabolic disorder, with reported incidence of one per 300,000-500,000 births generally, and hyperglycemia develops within the first 6 months of life (1-4). NDM is classified into two categories clinically. One is transient NDM (TNDM), in which insulin secretion is spontaneously recovered by several months of age, but sometimes recurs later, and the other is permanent NDM (PNDM), requiring lifelong medication. Recent molecular analysis of NDM identified at least 12 genetic abnormalities: chromosome 6q24, KCNJ11, ABCC8, INS, FOXP3, GCK, IPF1, PTF1A, EIF2AK3, GLUT2, HNF1β, and GLIS3 (5-22)...
November 3, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27805301/effects-of-deletion-polymorphism-in-ugt2b17-gene-on-prognosis-in-pediatric-cancer
#10
Sae Ishimaru, Yuza Yuki, Takashi Kaneko, Mitsuyoshi Urashima
BACKGROUND: The UDP-glucuronosyltransferase 2 family, polypeptide B17 (UGT2B17) gene encodes an enzyme that modifies carcinogens, C19 steroids, xenobiotics, and anticancer chemotherapeutic agents by glucuronidation. Pediatric cancers are much more sensitive to anticancer agents than adult cancers. Therefore, we examined the effects of a deletion polymorphism in the UGT2B17 gene on prognosis in pediatric cancer. METHODS: A total of 145 DNA samples were collected from children with malignant diseases...
November 2, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27805287/nutritional-status-and-feeding-problems-of-children-with-attention-deficit-hyperactivity-disorder
#11
Norsuhaila Sha'ari, Zahara Abdul Manaf, Mahadir Ahmad, Fairuz Nazri Abd Rahman
OBJECTIVE: Children with attention deficit hyperactivity disorder (ADHD) maybe at risk for nutrient deficiencies due to attention demands required to sit through meals. This comparative cross-sectional study was carried out to determine the nutritional status and feeding problems of ADHD children aged 4-12 years. METHOD: Sociodemographic data, anthropometric measurements and a three-day dietary intake were collected from 54 ADHD children and 54 typical development (TD) children...
November 2, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27759903/long-term-follow-up-for-hospitalized-children-with-anorexia-nervosa-restricting-type
#12
Keiji Tasaka, Kousaku Matsubara, Shizuo Takamiya, Shin-Ichi Ishikawa, Aya Iwata, Hiroyuki Nigami
BACKGROUND: Information on long-term follow-up of childhood-onset anorexia nervosa is scarce. This study aimed to show long-term (>10 years) course, outcome and prognostic factors for hospitalized childhood-onset anorexia nervosa-restricting type (ANR). METHODS: Forty-one ANR girls admitted to a single regional center participated. Median age at first admission was 13.3 (range: 8.6-15.6) years. The longitudinal clinical course was retrospectively determined for a median follow-up period of 17...
October 19, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27743415/targeted-use-of-prednisolone-with-second-ivig-for-refractory-kawasaki-disease
#13
Mitsuaki Kimura, Masashi Harazaki, Tetsuya Fukuoka, Isao Asakura, Hidemasa Sakai, Tsutomu Kamimaki, Ichiro Ohkawara, Naoe Akiyama, Satoshi Tsurui, Satoru Iwashima, Masaki Shimomura, Hideaki Morishita, Takaaki Meguro, Shiro Seto
BACKGROUND: Prednisolone (PSL) has been suggested to be useful for the treatment of patients with Kawasaki disease (KD) resistant to intravenous immunoglobulin (IVIG). However, much remains to be elucidated regarding its proper use. METHODS: Two-stage multicenter prospective studies involving 1,087 subjects were performed to study the effects of acute phase therapy on IVIG-resistant KD. Subjects resistant to the first dose of IVIG were classified into high (≥ 10 mg/dL) and low (< 10 mg/dL) CRP groups according to serum CRP levels after the first dose of IVIG...
October 15, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27709778/liver-fibrosis-with-hypereosinophilia-causing-transient-abnormal-myelopoiesis
#14
Shunsuke Minakata, Naoki Sakata, Norihisa Wada, Yuhei Konishi, Satoshi Marutani, Takuji Enya, Hidenori Nakagawa, Hiroshi Wada, Tsukasa Takemura
Transient abnormal myelopoesis is mostly self-resolving and has a good prognosis, but some patients subsequently die of liver fibrosis. We report the case of an infant with Down syndrome who developed life-threatening liver fibrosis at the same time as the blasts were about to disappear. This patient also had a marked increase in eosinophils, which were possibly harboring a GATA1 mutation and were expressing a high level of platelet-derived growth factor-B mRNA; these may have been involved in the development of liver fibrosis...
October 6, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27706892/oxygen-delivery-using-neonatal-self-inflating-bags-without-reservoirs
#15
Takahiro Sugiura, Rei Urushibata, Kenji Komatsu, Tsutomu Shioda, Tatsuki Ota, Megumi Sato, Yumiko Okubo, Tetsuya Fukuoka, Shigeharu Hosono, Masanori Tamura
BACKGROUND: Guidelines recommend avoiding excessive oxygen administration during neonatal resuscitation. Recent studies have suggested that oxygen titration can be achieved using a self-inflating bag. However, only a few data have supported the effectiveness of resuscitators used in neonatal ventilation. The aim of this study is to determine the amount of oxygen delivered using several brands of neonatal self-inflating resuscitation bags without reservoirs under several conditions, including different oxygen flow rates, ventilation rates (VR), peak inspiratory pressure (PIP) ranges, and test lung compliances...
October 5, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27706882/evaluation-of-fecal-retention-via-ultrasonography-in-childhood
#16
Reiko Hatori, Takeshi Tomomasa, Takashi Ishige, Maiko Tatsuki, Hirokazu Arakawa
BACKGROUND: To assess the usefulness of rectal diameter measurement via ultrasonography as a diagnostic tool for fecal retention in children. METHODS: One hundred children (median age: 5.0 years), consisting of 80 with functional constipation and 20 without constipation, participated in the study. All patients underwent physical examination that included digital rectal examination. Forty-five children underwent ultrasonography in three differential planes: transection above the symphysis, under the ischial spine, and at the bladder neck...
October 5, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27706877/mechanism-of-auditory-hypersensitivity-in-human-autism-using-autism-model-rats
#17
Michiru Ida-Eto, Nao Hara, Takeshi Ohkawara, Masaaki Narita
BACKGROUND: Auditory hypersensitivity is one of the major complications accompanied by autism spectrum disorders. The aim of this study is to investigate whether auditory brain center is affected in autism model rats. METHODS: Autism model rats were prepared by prenatal exposure to thalidomide, which is administered to embryonic day 9 and 10 of pregnant rats. Superior olivary complex (SOC), a complex of auditory nuclei, was immunostained with anti-calbindin d28k antibody at postnatal day 50...
October 5, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27696630/single-center-experience-of-extracorporeal-membrane-oxygenation-in-61-neonates
#18
Eiji Hirakawa, Satoshi Ibara, Takuya Tokuhisa, Yoshinobu Maede, Takako Kuwahara, Chie Ishihara, Hiroyuki Noguchi, Yoshiki Naitou, Masakatsu Yamamoto, Masaya Kibe, Tsuyoshi Yamamoto, Tomonori Kurimoto, Masato Kamitomo, Kazutoshi Cho, Hisanori Minakami
BACKGROUND: There have been few reports regarding outcomes after extracorporeal membrane oxygenation (ECMO) in newborn Japanese infants. METHODS: A review of 61 neonates with ECMO through January 1995 at a single center was performed. ECMO was used in neonates with oxygenation index > 20 after conventional treatments. Background factors, such as etiology, vascular access mode (veno-venous [VV] or veno-arterial [VA]), number of days with ECMO, and early ECMO (within 24 hours after birth), were analyzed in relation to outcome with respect to survival to hospital discharge (SHD)...
October 3, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27696625/maternal-zinc-deficiency-and-congenital-anomalies-in-newborns
#19
Mahmood Moghimi, Sahar Ashrafzadeh, Sepehr Rassi, Ali Naseh
BACKGROUND: Zinc deficiency in pregnant women is common, especially in the third trimester of pregnancy. However, the available data are insufficient regarding the association between zinc deficiency and congenital malformations in Iranian population. We aimed to evaluate if the maternal serum zinc deficiency is associated with development of major congenital malformations in the newborns. METHODS: This descriptive, case-control study was performed in mothers of 80 neonates with congenital anomalies (Case group) who were admitted to the Mofid Children's Hospital, Tehran, Iran...
October 3, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27696583/yield-and-complications-of-kidney-biopsies-over-two-decades-in-a-tertiary-pediatric-center
#20
Roei Hod Feins, Anna Tobar, Miriam Davidovits
BACKGROUND: Kidney biopsy serves as an adjunct for the diagnosis of renal disease. However, it is not always productive. This study evaluated the yield and risks of kidney biopsies performed in 1995-2014 at a tertiary pediatric medical center. METHODS: The medical files of all patients who underwent closed percutaneous biopsy for various indications in native or transplanted kidneys were retrospectively reviewed for patient characteristics, technical and histopathologic findings, biopsy yield, and biopsy complications...
October 3, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
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