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Pediatrics International: Official Journal of the Japan Pediatric Society

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https://www.readbyqxmd.com/read/28207965/is-colchicine-more-effective-to-prevent-pfapa-episodes-in-mefv-variants
#1
Muhammed Gunes, Sukru Cekic, Sara Sebnem Kilic
BACKGROUND: Periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) syndrome is the most frequent repetitive fever syndrome in childhood. It is characterized with fever episodes lasting for about three to six days, once every three to eight weeks. METHODS: Clinical and laboratory data of patients with PFAPA syndrome between January 2010 and December 2014 followed up at a tertiary pediatric care hospital were reviewed. RESULTS: Four-hundred children (256 male, 144 female), the mean age at diagnosis was 4...
February 16, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28207964/impaired-nephrogenesis-in-neonatal-rats-with-oxygen-induced-retinopathy
#2
Mayu Nakagawa, Naoto Nishizaki, Amane Endo, Tomonosuke Someya, Yuta Saito, Akira Mizutani, Taichi Hara, Yayoi Murano, Koji Sakuraya, Satoshi Hara, Daisuke Umino, Daishi Hirano, Shuichiro Fujinaga, Yoshiyuki Ohtomo, Toshiaki Shimizu
OBJECTIVES: Preterm neonates are born while nephrogenesis is ongoing and are commonly exposed to factors in a hyperoxic environment that can impair renal development. Oxidative stress has also been implicated in the development of retinopathy of prematurity (ROP). The rat model of oxygen-induced retinopathy (OIR) is the most clinically relevant model of ROP because its biologic features closely resemble those of ROP in preterm infants. We investigated impaired renal development in a rat model of OIR...
February 16, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28199782/social-independence-among-adult-congenital-heart-disease-patients-in-japan
#3
Ryota Ochiai, Yukitaka Ikeda, Hitoshi Kato, Isao Shiraishi
BACKGROUND: As treatment outcomes for congenital heart disease have improved, the social independence of adult congenital heart disease patients has become a key goal. We aimed to (1) determine the relationship between social independence and psychological profiles in these patients, and (2) identify patient anxieties, difficulties, and demands related to life in society. METHODS: A total of 143 patients aged ≥15 years who had physical disability certificates were selected using a questionnaire distributed by a patients association...
February 15, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28181715/development-of-age-based-weight-estimation-formulae-for-japanese-children
#4
Nobuyuki Nosaka, Takashi Yorifuji, Emily Knaup, Kohei Tsukahara, Takashi Muguruma, Ayumi Okada, Hirokazu Tsukahara, Hiroyuki Doi
BACKGROUND: Although dosing and sizing of resuscitation drugs and equipment are mostly weight based, time is usually insufficient to weigh critically ill children. Many age-based weight estimation formulae for emergency use have been developed worldwide; however, there is no specific formula for Japanese children. This study aimed to develop and validate age-based formulae for estimating body weight of children living in Japan. METHODS: We obtained 370,980 measurements of body weight from 39,547 participants aged 12-155 months...
February 9, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28177185/effect-of-bronchopulmonary-dysplasia-on-the-early-intellectual-development-of-preterm-infants
#5
Fatao Lin, Haipeng Dong, Yanyan Song, Tengwei Zhang, Junye Qi, Xuwen Xiao, Yueju Cai
OBJECTIVE: This study aimed to explore the effect of bronchopulmonary dysplasia (BPD) on the early intellectual development of preterm infants. METHODS: From 2011 to 2015, 83 preterm infants diagnosed with BPD were recruited to the BPD group, and 89 preterm infants without BPD and 98 healthy term infants were randomly recruited to the non-BPD and term group, respectively. Neural and intellectual development according to the Gesell Development Scale were evaluated and compared between groups at 0-3 months, 3-6 months, 6-9 months, and 9-12 months of adjusted age for preterm infants and real age for term infants...
February 8, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28177180/decrease-in-use-of-contraindicated-drugs-with-automated-alerts-in-the-pediatric-population
#6
Inmyung Song, Han Na Shin, Ju-Young Shin
BACKGROUND: This study aims to evaluate changes in the use of contraindicated drugs with automated alerts through the nationwide drug utilization review in the pediatric population. METHODS: We conducted an interrupted time series analysis using the nationwide health insurance database. Study drugs were a total of 72 drugs in 22 classes that were designated as age-contraindicated between January 2007 and December 2011. Study subjects consisted of the patients in Korea who had been prescribed with any of the study drugs at least once...
February 8, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28164411/medical-care-focused-time-study-of-the-care-for-medically-dependent-smid
#7
Tadashi Matsubasa, Hiroshi Mitsubuchi, Akihiko Kimura, Makoto Shinohara, Fumio Endo
BACKGROUND: Improvements in neonatal medicine and pediatric emergency medicine has led to increasing number of children with severe disabilities requiring medical care, such as tracheal suction, on a daily basis. Most of these children, discharged directly from hospitals to their parents' homes, need home medical support. To provide data for the establishment of appropriate support systems we analyzed the care for such children through a time study conducted at an institution. METHODS: We performed a minute-by -minute time study of the work of 33 staff members in a ward for patients (medically-dependent SMID) requiring frequent medical care over 48 hours in order to analyze patient care...
February 6, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28135025/acute-liver-dysfunction-not-resulting-from-hepatitis-viruses-in-immunocompetent-children
#8
Tomoyuki Tsunoda, Ayano Inui, Kentaro Iwasawa, Manari Oikawa, Tsuyoshi Sogo, Haruki Komatsu, Yoshinori Ito, Tomoo Fujisawa
BACKGROUND: The objective of the present study was to clarify the roles of cytomegalovirus (CMV), Epstein-Barr virus (EBV), and human herpesvirus 6 (HHV-6) in immunocompetent children with acute liver dysfunction not resulting from hepatitis viruses. METHODS: Sixty-eight children (median age 3 years) hospitalized as a result of acute liver dysfunction were enrolled in this study. Hepatitis A, B, and C were excluded. The prevalence of CMV, EBV, and HHV-6 and each viral DNA load in whole blood was prospectively evaluated using multiplex real-time PCR...
January 30, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28118513/transcutaneous-bilirubin-measurement-during-phototherapy-in-term-neonates
#9
Yoshinori Katayama, Masahiro Enomoto, Shin Kikuchi, Atsuko Takei, Hitoshi Ikegami, Hirotaka Minami, Yong Kye Lee
BACKGROUND: We tested whether direct transcutaneous bilirubin (TcB) measurement from an area unexposed to phototherapy is reliable to estimate total serum bilirubin (TSB) in neonates during phototherapy and whether it contributes to a reduction in TSB blood sampling when deciding to discontinue phototherapy. METHODS: We performed a retrospective observational study in term neonates who received phototherapy in the mother's room. TSB and TcB from the neonate's sternum were measured before and during phototherapy and compared with a linear regression analysis and a Bland-Altman plot, respectively...
January 24, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28117531/late-onset-circulatory-collapse-of-prematurity
#10
Masahiko Kawai
Some very-low-birth-weight (VLBW) infants develop refractory hypotension, which is resistant to intravenous volume expanders and inotropes, but responds to exogenous glucocorticoid dramatically.(1-8) Such refractory hypotension usually occurs just after birth or within the early neonatal period (<Day 7). However, cases of refractory hypotension after the early neonatal period (>Day 7) have been reported since 2000 in Japan.(9) In typical cases, infants are stabilized for a period within the early neonatal period, and the sudden onset of circulatory collapse then subsequently occurs...
January 24, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28097746/a-high-neutrophil-to-lymphocyte-ratio-is-associated-with-refractory-kawasaki-disease
#11
Hong-Je Cho, So Young Bak, Su Yeong Kim, Rita Yoo, Hae-Sung Baek, Seung Yang, Il-Tae Hwang, Ji-Eun Ban
BACKGROUND: The clinical significance of the neutrophil to lymphocyte ratio (NLR) has not yet been fully elucidated in patients with Kawasaki disease (KD). The purpose of this study is to investigate the relationship between NLR and the response to intravenous immunoglobulin (IVIG) therapy affecting coronary abnormalities in KD METHODS: A total of 196 patients of KD who were treated with IVIG therapy were analyzed. We evaluated the baseline NLR immediately before IVIG therapy and classified the study patients into 2 groups according to the value of the NLR...
January 18, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28083971/lipoblastoma-in-children-a-review-of-12-cases
#12
Hilal Susam Sen, Bilgehan Yalcin, Tezer Kutluk, Feridun Cahit Tanyel, Mithat Haliloglu, Diclehan Orhan, Burca Aydın, Nilgun Kurucu, Ali Varan, Canan Akyuz
BACKGROUND: Lipoblastoma is a rare benign mesenchymal tumor of infancy and early childhood. Symptoms vary depending on localization, signs of compression of adjacent organs may be seen. METHODS: A total of 12 children with pathologically proven lipoblastoma from 2000 to 2014 were reviewed retrospectively for their clinical features, treatment and follow-up. RESULTS: There were seven boys and five girls between 7.5 months to 7.5 years of age...
January 13, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28063246/exacerbation-caused-by-5-asa-intolerance-in-children-with-ulcerative-colitis
#13
Hirotaka Shimizu, Katsuhiro Arai, Julian Tang, Kenji Hosoi, Rie Funayama
BACKGROUND: 5-aminosalicylate (5-ASA) is widely used as the first-line drug for ulcerative colitis (UC). 5-ASA is mostly a safe and effective drug, but it can bring about exacerbation due to 5-ASA intolerance. 5-ASA intolerance can be confusing and it can mislead physicians to consider unnecessary treatment escalation plan including corticosteroid (CS), biologics, or even surgery. In spite of the clinical importance of 5-ASA intolerance, there have been few publications about its incidence, clinical features, and diagnosis...
January 7, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28063223/neurally-adjusted-ventilatory-assist-for-infants-under-prolonged-ventilation
#14
Juyoung Lee, Han-Suk Kim, Young Hwa Jung, Chang Won Choi, Yong Hoon Jun
BACKGROUND: Severe bronchopulmonary dysplasia (BPD) often leads to prolonged mechanical ventilation lasting several months. Cyanotic episodes frequently occur in these patients, which necessitate long-term sedation and/or intermittent muscle paralysis. Neurally adjusted ventilatory assist (NAVA) might provide precisely the amount of support that these patients need without sedation. METHODS: We reviewed the medical records of preterm infants who underwent a tracheostomy and required mechanical ventilation for more than 6 months during a period of 6 years...
January 7, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28032933/swimming-attendance-during-childhood-and-development-of-asthma-a-meta-analysis
#15
F Valeriani, C Protano, M Vitali, V Romano Spica
BACKGROUND: The association between asthma and swimming pool attendance has not been demonstrated and contrasting results emerged. In order to clarify the association between asthma diagnosis in children and swimming pool attendance, and to assess the consistency of findings of the available epidemiological studies, we completed a literature analysis focusing on literature about the relationship between the exposure to disinfection by-products in indoor swimming pool during childhood and asthma diagnosis...
December 29, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28026886/haploidentical-hematopoietic-cell-transplantation-for-disseminated-ewing-sarcoma
#16
Hiroki Yoshihara, Tadashi Kumamoto, Rintaro Ono, Keiko Akahane, Taiki Nozaki, Shogo Kobayashi, Atsushi Kikuta, Seiichi Matsumoto, Daisuke Hasegawa, Chitose Ogawa, Atsushi Manabe
We describe the case of a 13-year-old girl with multifocal disseminated Ewing sarcoma family of tumor (ESFT) who received a 5/8 human leukocyte antigen-matched haploidentical hematopoietic cell transplantation to generate a graft-versus-tumor effect. The patient had grade 2 acute graft-versus-host disease (GVHD) of the skin and chronic GVHD nausea and abdominal pain that required prednisolone for 17 months, but has been free from ESFT for 3 years 10 months after therapy. The present case suggests a beneficial effect of haploidentical hematopoietic cell transplantation in disseminated ESFT...
December 27, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28009466/clinical-characteristics-of-urethral-prolapse-in-japanese-children
#17
Takahito Ninomiya, Hiroshi Koga
BACKGOUND: Urethral prolapse (UP) in children is a rare condition and has commonly been reported in Black girls. The aim of this study was to elucidate the status of medical management for UP in Japanese children. METHODS: A secondary data analysis was conducted in Japanese children ≤15 years old with UP. The relationship between initial treatment approach and outcome was investigated, with symptom persistence or recurrence defined as treatment failure. RESULTS: Of 77 cases of UP in Japanese children reported since 1972, initial surgical treatment was performed in 42 cases (55%) and nonsurgical treatment in 35 cases (45%)...
December 23, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27973698/acute-intoxication-due-to-wisteria-floribunda-seed-in-seven-young-children
#18
Dongwan Kim, Jihyoung Park, Yun Mi Kim, Hann Tchah
BACKGROUND: Wisteria floribunda (W. floribunda) is a vine commonly found in Korea, Japan, and US. The objective of this observational study is to assess the toxicity of W. floribunda seed in young children. METHODS: Of 28 children in a kindergarten who participated in a field trip, seven ingested W. floribunda seeds, six half of the seed and one a whole seed. These seven children were admitted to the Gachon University Gil Medical Center [Incheon, Korea]. RESULTS: All of the children had vomiting within the four hours of ingesting the W...
December 14, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27935231/prolonged-tacrolimus-use-for-pediatric-gastrointestinal-disorder-a-double-edged-sword
#19
Kenji Hosoi, Katsuhiro Arai, Kentaro Matsuoka, Hirotaka Shimizu, Koichi Kamei, Atsuko Nakazawa, Toshiaki Shimizu, Julian Tang, Shuichi Ito
BACKGROUND: Although tacrolimus (TAC) appeared useful in inducing remission in children with refractory inflammatory bowel disease (IBD) or autoimmune gastroenteropathy (AGE), its use in maintenance therapy remains controversial. The aim of this study was to reveal the potential nephrotoxic nature of prolonged TAC use. METHODS: This retrospective study reviews children with gastrointestinal disorder who underwent kidney biopsy for the evaluation of renal damage during TAC therapy of over one year...
December 9, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27935218/is-there-a-relationship-between-neonatal-sepsis-and-simple-minor-neurological-dysfunction
#20
Nazan Kavas, Ayşe Engin Arısoy, Asuman Bayhan, Bülent Kara, Ayla Günlemez, Gülcan Türker, Meral Oruç, Ayşe Sevim Gökalp
BACKGROUND: This study examined potential risk factors for and consequences of simple minor neurological dysfunction (SMND), in a group of very low birth weight newborns followed until preschool age. METHODS: This is a prospective longitudinal study. Children with a birth weight below 1,500 g were assessed at 4 to 6 years of age. Twenty eight children with a normal neurological examination and 35 children with simple minor neurological dysfunction were included in the final analysis...
December 9, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
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