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Pediatrics International: Official Journal of the Japan Pediatric Society

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https://www.readbyqxmd.com/read/29350882/cardiac-function-by-three-dimensional-speckle-tracking-imaging-and-cytokines-in-kawasaki-disease
#1
Masataka Kato, Mamoru Ayusawa, Hirofumi Watanabe, Akiko Komori, Yuriko Abe, Takahiro Nakamura, Hiroshi Kamiyama, Shori Takahashi
BACKGROUND: IT is well known that serum N-terminal pro brain natriuretic peptide (NT-proBNP) tends to elevate in acute phase of Kawasaki disease (KD), but the cause of NT-proBNP elevation has not been clarified. Our previous study revealed that cardiac function evaluated by two-dimensional echocardiography (2D-E) such as ejection fraction (EF) was normal. However, cardiac function evaluated by 2D-E does not reflect subtle change of cardiac dysfunction and the relation has still been controversial...
January 19, 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29341364/food-dependent-exercise-induced-anaphylaxis-in-japanese-elementary-school-children
#2
Tetsuharu Manabe, Norihiro Oku, Yukoh Aihara
BACKGROUND: In 2012, we clarified that the prevalence of food-dependent exercise-induced anaphylaxis (FDEIA) was 0.018% among junior-high students in Yokohama, Japan. Furthermore, although different from FDEIA, one student who had completed oral immunotherapy developed anaphylaxis during exercise after eating causative food. However, there have been few large-scale epidemiological studies of FDEIA in elementary school children, so we conducted the epidemiological study among elementary school children in Yokohama to clarify the frequency and characteristic of FDEIA...
January 17, 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29337407/insufficient-sleep-syndrome-an-unrecognized-but-important-clinical-entity
#3
Jun Kohyama, Yuki Anzai, Makoto Ono, Ai Kishino, Keita Tamanuki, Kazuma Takada, Kento Inoue, Maho Horiuchi, Yoshiho Hatai
BACKGROUND: In the Tokyo Bay Urayasu Ichikawa Medical Centre, a sleep clinic for adults and children was established in August 2012. As few sleep clinics are available in Japan that are specifically for children, this clinic provides the opportunity to provide data on child patients who have been suffering from sleep problems and who visited the sleep clinic. METHODS: Records of patients who visited the sleep clinic at the Tokyo Bay Urayasu Ichikawa Medical Centre at the age of 20 years or younger on their first visit were retrospectively examined, and their initial and final diagnoses were examined...
January 16, 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29316008/urinary-aquaporin-2-as-a-possible-objective-biomarker-of-nocturnal-polyuria
#4
Yuko Tasaki, Masaki Shimizu, Maiko Takarkura, Kazuhide Ohta, Akihiro Yachie
No abstract text is available yet for this article.
January 7, 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29297961/serum-antibodies-against-oxidized-ldl-in-children-and-adolescents-with-and-without-hypercholesterolemia
#5
Anastasia Garoufi, Antonios Marmarinos, Venetia-Maria Vraila, Stamatina Dimou, Athanasia Pagoni, Styliani Vorre, Irene Paraskakis, Dimitrios Gourgiotis
BACKGROUND: The oxidative modification of LDL (oxLDL) appears to play a key role in the early developmental stages of atherosclerosis. Increased serum antibodies against the oxLDL (anti-oxLDL antibodies) have been found in adults with atherosclerotic diseases, as well as in healthy ones. However, the clinical significance and its precise role, atherogenic or atheroprotective, have not been yet clarified. This study aims in evaluating anti-oxLDL antibodies in healthy children and adolescents with- and without hypercholesterolemia...
January 3, 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29297955/predictive-factors-for-response-to-ivig-in-children-with-itp
#6
Yukiko Higashide, Tsukasa Hori, Yuko Yoto, Hiroyuki Kabutoya, Saho Honjo, Yoshiyuki Sakai, Masanori Nojima, Minami Yoda, Masaki Yamamoto, Hiroyuki Tsutsumi
BACKGROUND: Immune thrombocytopenic purpura (ITP) is commonly treated with intravenous immunoglobulin (IVIG). METHODS: We retrospectively evaluated whether pretreatment clinical and laboratory findings could predict the short- and long-term response to IVIG. RESULTS: Short-term response was estimated by platelet counts 2 weeks after IVIG, and long-term response was assessed by thrombocytopenia-free survival (TFS). TFS was defined as the probability of survival without treatment failure after initial IVIG, such as relapse, requiring additional therapeutic interventions, or progressing to chronic ITP...
January 3, 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29292568/effect-of-intravenous-immunoglobulin-within-day-4-of-illness-in-kawasaki-disease
#7
Yusuke Shiozawa, Ryo Inuzuka, Shindo Takahiro, Ryo Mafune, Taiyu Hayashi, Yoichiro Hirata, Nobutaka Shimizu, Jun Inatomi, Yoshiki Yokoyama, Yoshiyuki Namai, Yoichiro Oda, Masaru Takamizawa, Yutaka Harita, Takuya Kawahara, Akira Oka
BACKGROUND: Although early treatment of Kawasaki disease (KD) with intravenous immunoglobulin (IVIG) is expected to prevent coronary artery abnormalities, the effectiveness of IVIG within day 4 of illness remains to be determined. METHODS: This was a multi-institutional, retrospective cohort study. Patients diagnosed with KD within day 4 were divided into two groups: those who received initial IVIG before and at day 5 of illness. Baseline characteristics were adjusted using propensity scores...
January 2, 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29290099/transition-in-patients-with-coronary-artery-lesions-after-kawasaki-disease
#8
Hiroshi Kamiyama, Mamoru Ayusawa, Shunichi Ogawa, Tsutomu Saji, Kenji Hamaoka
BACKGROUND: Discussion of health care transition (HCT) for adults with a childhood history of coronary artery lesions (CAL) after Kawasaki disease (KD) is important. A nationwide questionnaire survey was performed with support by the Japanese Society of Kawasaki Disease. The purpose of this study is to clarify the reality of HCT and loss to follow-up in patients with CAL after KD. METHODS: The survey was e-mailed to 48 members of the Japanese Society of Kawasaki Disease from May to July 2014...
December 31, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29290098/rotavirus-infection-as-a-frequent-cause-of-neonatal-fever
#9
Ha-Na Kang, Hyun Kyung Park, Hyun-Ju Lee, Jin-Hwa Moon, Jae Won Oh, Chang-Ryul Kim
BACKGROUND: Fever rather than diarrhea or vomiting was the most common symptom of neonatal rotavirus(RV) infection in our previous study. We investigated if RV infection is a major cause of neonatal fever and we compared the clinical characteristics of bacterial infections, viral infections and unknown causes of neonatal fever. METHOD: We reviewed the electronic medical records of 48 newborns of ≤ 28 days who were admitted to the Special Care Nursery of Hanyang University Guri Hospital for fever (≥ 38°C) from 2005 to 2009...
December 31, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29290097/challenges-in-developing-mucosal-vaccine-and-antibodies-against-infectious-diarrhea-in-children
#10
REVIEW
Daisuke Tokuhara
Infectious diarrhea in children can be life-threatening and imposes a large economic burden on healthcare systems, therefore more effective prophylactic and therapeutic drugs are needed urgently. Because most of the pathogens responsible for childhood diarrhea infect the gastrointestinal mucosa, providing protective immunity at the mucosal surface is an ideal way to control pathogen invasion and toxic activity. Mucosal (e.g., oral, nasal) vaccines are superior to systemic (subcutaneous or intramuscular) vaccination for conferring both mucosal and systemic pathogen-specific immune responses...
December 31, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29290095/parental-alexithymia-depression-and-anxiety-levels-of-children-with-neurodevelopmental-disorders-a-comparative-study-with-pervasive-developmental-disorders-and-adhd
#11
Ibrahim Durukan, Koray Kara, Mahmoud Almbaideen, Dursun Karaman, Hesna Gül
BACKGROUND: Recent studies showed that individuals with neurodevelopmental disorders and their relatives have problems to express and recognize emotions but there is a lack of studies concerning alexithymia levels and relationships between parental alexithymia and depression-anxiety symptoms in these groups. OBJECTIVE: We aimed to determine alexithymia, depression, anxiety levels of parents in children with pervasive developmental disorders and ADHD, also examine if there is a positive correlation between child's neurodevelopmental problem's severity and parental scores...
December 31, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29290091/breastfeeding-regulates-development-of-immune-system-through-tgf-%C3%AE-in-mice-pups
#12
Keita Sakaguchi, Akemi Koyanagi, Fumitaka Kamachi, Akiko Harauma, Asako Chiba, Ken Hisata, Toru Moriguchi, Toshiaki Shimizu, Sachiko Miyake
BACKGROUND: Breast milk contains important nutrients and immunoregulatory factors that are essential for newborn infants. Recently, epidemiological studies suggested that breastfeeding prevents a wide range of infectious diseases and lowers the incidence of infant allergic diseases. METHODS: To examine the effects of breast milk in immunological development in infancy, we established an artificial rearing system for hand-feeding mice and compared mouse pups fed with either breast milk or milk substitute...
December 31, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29288550/a-questionnaire-survey-for-parents-in-nara-prefecture-japan-about-mumps-vaccination
#13
Taito Kitano, Hiroki Nishikawa, Masayuki Onaka, Mariko Ishihara, Atsuko Nishiyama, Sayaka Yoshida
OBJECTIVES: Although the mumps vaccine has not been included in the national immunization program (NIP) in Japan, it has been shown that a two-dose routine vaccine program would be highly cost-effective. In this study, we performed a questionnaire-based study to investigate how many Japanese parents want the mumps vaccine to be included in the NIP with proper information. MATERIALS AND METHODS: The questionnaire was given to parents who visited the Pediatrics or NICU department of Nara Prefecture General Medical Center, Nara City, Japan, between March 1, 2017 and August 31, 2017...
December 30, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29288522/survey-of-rotavirus-associated-severe-complications-in-aichi-prefecture
#14
Fumihiko Hattori, Yoshiki Kawamura, Jun-Ichi Kawada, Seiji Kojima, Jun Natsume, Koichi Ito, Shinji Saito, Yoshiro Kitagawa, Akihisa Okumura, Tetsushi Yoshikawa
BACKGROUND: Rotavirus can rarely cause severe complications such as encephalopathy/encephalitis, myocarditis, sudden unexpected death, urinary stone, and gastrointestinal bleeding; indeed incidence of these severe complications remains unclear. Additionally, it has not been determined whether rotavirus vaccine could reduce the cases with the severe complications or not. METHOD: A two-part questionnaire was designed to determine the number and clinical features of the cases with the severe complications between September 1st 2008 and August 31st 2015 including the observation periods before and after rotavirus vaccine introduction in Aichi prefecture...
December 29, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29288517/proposal-for-the-development-of-biologics-in-pediatric-rheumatology-field
#15
REVIEW
Masaaki Mori, Masao Nakagawa, Nao Tsuchida, Kou Kawada, Junko Sato, Michiyo Sakiyama, Shinya Hirano, Katsuaki Sato, Hidefumi Nakamura
In order to aim at the development, approval and early introduction into clinical practice of biologics in pediatric field, we investigated the present situation of the development to approval of biologics as anti-rheumatic agents for children in Japan, visualize the present problems and give a proposal for the future. As results of analysis in various directions, it is apparent that the duration of a review period required for the preparation of clinical trials and the approval in PMDA clearly reduced compared with the past...
December 29, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29281158/treatment-outcomes-according-to-underlying-disease-in-pediatric-renovascular-hypertension
#16
Yeonhee Lee, Young Shin Lim, Sang Taek Lee, Heeyeon Cho
BACKGROUND: Renovascular hypertension (RVH) accounts for 5-10% of pediatric hypertension, and can be associated with underlying disease involving other organs. The purpose of this study was to evaluate the clinical characteristics and assess the treatment outcomes of Korean pediatric patients with RVH. METHODS: The medical records of 25 Korean pediatric patients with RVH were retrospectively reviewed. RESULTS: Twenty-four patients had underlying disease, and the most common cause was Moyamoya disease (MMD) (n = 10, 40%)...
December 27, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29280262/prognostic-factors-in-the-early-phase-of-acute-encephalopathy
#17
Chizu Oba, Mitsuru Kashiwagi, Takuya Tanabe, Shohei Nomura, Motoko Ogino, Takuya Matsuda, Shinya Murata, Michiko Nakamura, Akihiko Shirasu, Keisuke Inoue, Keisuke Okasora, Hiroshi Tamai
BACKGROUND: Neurological sequelae occur in 40% of patients with acute encephalopathy. The early prediction of poor outcomes is critical to the initiation of appropriate treatment. In the present study, we aimed to elucidate prognostic factors that can be quickly and feasibly evaluated upon hospital admission in patients with acute encephalopathy. METHODS: We analyzed data from 51 patients with acute encephalopathy who had been admitted to Hirakata City Hospital between January 2005 and December 2014...
December 27, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29271533/eltrombopag-with-i-v-immunoglobulin-for-safe-splenectomy-in-refractory-immune-thrombocytopenia
#18
Miyako Kanno, Tadashi Onoda, Tohru Meguro, Hiroko Sato, Tetsuo Mitsui
No abstract text is available yet for this article.
December 22, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29266671/transcoronary-cell-infusion-with-the-stop-flow-technique-in-children-with-single-ventricle-physiology
#19
Takahiro Eitoku, Kenji Baba, Maiko Kondou, Yoshihiko Kurita, Yousuke Fukushima, Kenta Hirai, Shinichi Ohtsuki, Shuta Ishigami, Shunji Sano, Hidemasa Oh
BACKGROUND: Almost all cardiac regeneration therapy haves been reported in adults. However, only a few reports have focused on transcoronary infusion of cardiac progenitor cells by using the stop-flow technique in children. METHODS: Intracoronary autologous cardiosphere-derived cell (CDCs) transfer was conducted at Okayama University as a phase 1 clinical trial for 7 patients with hypoplastic left heart syndrome between January 2011 and December 2012, and as a phase 2 clinical trial for 34 patients with single-ventricle physiology between July 2013 and March 2015...
December 21, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29266574/pregnancy-outcomes-of-female-childhood-cancer-survivors-a-nationwide-survey-in-japan
#20
Masaki Sekiguchi, Yoko Miyoshi, Norihiko Kikuchi, Haruhiko Sago
BACKGROUND: The aim of this study was to investigate the outcomes of pregnancies among female childhood cancer survivors (CCSs) in Japan to encourage greater attention to the reproductive health of CCSs. METHODS: This study was a retrospective nationwide survey using a questionnaire on deliveries at ≥22 weeks of gestation in CCSs at perinatal centers registered with the Japanese Perinatologists Association between 2010 and 2014. We evaluated the maternal characteristics, pregnancy and neonatal outcomes and the relationship between cancer treatments and these outcomes...
December 20, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
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