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Pediatrics International: Official Journal of the Japan Pediatric Society

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https://www.readbyqxmd.com/read/28097746/a-high-neutrophil-to-lymphocyte-ratio-is-associated-with-refractory-kawasaki-disease
#1
Hong-Je Cho, So Young Bak, Su Yeong Kim, Rita Yoo, Hae-Sung Baek, Seung Yang, Il-Tae Hwang, Ji-Eun Ban
BACKGROUND: The clinical significance of the neutrophil to lymphocyte ratio (NLR) has not yet been fully elucidated in patients with Kawasaki disease (KD). The purpose of this study is to investigate the relationship between NLR and the response to intravenous immunoglobulin (IVIG) therapy affecting coronary abnormalities in KD METHODS: A total of 196 patients of KD who were treated with IVIG therapy were analyzed. We evaluated the baseline NLR immediately before IVIG therapy and classified the study patients into 2 groups according to the value of the NLR...
January 18, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28083971/lipoblastoma-in-children-a-review-of-12-cases
#2
Hilal Susam Sen, Bilgehan Yalcin, Tezer Kutluk, Feridun Cahit Tanyel, Mithat Haliloglu, Diclehan Orhan, Burca Aydın, Nilgun Kurucu, Ali Varan, Canan Akyuz
BACKGROUND: Lipoblastoma is a rare benign mesenchymal tumor of infancy and early childhood. Symptoms vary depending on localization, signs of compression of adjacent organs may be seen. METHODS: A total of 12 children with pathologically proven lipoblastoma from 2000 to 2014 were reviewed retrospectively for their clinical features, treatment and follow-up. RESULTS: There were seven boys and five girls between 7.5 months to 7.5 years of age...
January 13, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28063246/exacerbation-caused-by-5-asa-intolerance-in-children-with-ulcerative-colitis
#3
Hirotaka Shimizu, Katsuhiro Arai, Julian Tang, Kenji Hosoi, Rie Funayama
BACKGROUND: 5-aminosalicylate (5-ASA) is widely used as the first-line drug for ulcerative colitis (UC). 5-ASA is mostly a safe and effective drug, but it can bring about exacerbation due to 5-ASA intolerance. 5-ASA intolerance can be confusing and it can mislead physicians to consider unnecessary treatment escalation plan including corticosteroid (CS), biologics, or even surgery. In spite of the clinical importance of 5-ASA intolerance, there have been few publications about its incidence, clinical features, and diagnosis...
January 7, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28063223/neurally-adjusted-ventilatory-assist-for-infants-under-prolonged-ventilation
#4
Juyoung Lee, Han-Suk Kim, Young Hwa Jung, Chang Won Choi, Yong Hoon Jun
BACKGROUND: Severe bronchopulmonary dysplasia (BPD) often leads to prolonged mechanical ventilation lasting several months. Cyanotic episodes frequently occur in these patients, which necessitate long-term sedation and/or intermittent muscle paralysis. Neurally adjusted ventilatory assist (NAVA) might provide precisely the amount of support that these patients need without sedation. METHODS: We reviewed the medical records of preterm infants who underwent a tracheostomy and required mechanical ventilation for more than 6 months during a period of 6 years...
January 7, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28032933/swimming-attendance-during-childhood-and-development-of-asthma-a-meta-analysis
#5
F Valeriani, C Protano, M Vitali, V Romano Spica
BACKGROUND: The association between asthma and swimming pool attendance has not been demonstrated and contrasting results emerged. In order to clarify the association between asthma diagnosis in children and swimming pool attendance, and to assess the consistency of findings of the available epidemiological studies, we completed a literature analysis focusing on literature about the relationship between the exposure to disinfection by-products in indoor swimming pool during childhood and asthma diagnosis...
December 29, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28026886/haploidentical-hematopoietic-cell-transplantation-for-disseminated-ewing-sarcoma
#6
Hiroki Yoshihara, Tadashi Kumamoto, Rintaro Ono, Keiko Akahane, Taiki Nozaki, Shogo Kobayashi, Atsushi Kikuta, Seiichi Matsumoto, Daisuke Hasegawa, Chitose Ogawa, Atsushi Manabe
We describe the case of a 13-year-old girl with multifocal disseminated Ewing sarcoma family of tumor (ESFT) who received a 5/8 human leukocyte antigen-matched haploidentical hematopoietic cell transplantation to generate a graft-versus-tumor effect. The patient had grade 2 acute graft-versus-host disease (GVHD) of the skin and chronic GVHD nausea and abdominal pain that required prednisolone for 17 months, but has been free from ESFT for 3 years 10 months after therapy. The present case suggests a beneficial effect of haploidentical hematopoietic cell transplantation in disseminated ESFT...
December 27, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28009466/clinical-characteristics-of-urethral-prolapse-in-japanese-children
#7
Takahito Ninomiya, Hiroshi Koga
BACKGOUND: Urethral prolapse (UP) in children is a rare condition and has commonly been reported in Black girls. The aim of this study was to elucidate the status of medical management for UP in Japanese children. METHODS: A secondary data analysis was conducted in Japanese children ≤15 years old with UP. The relationship between initial treatment approach and outcome was investigated, with symptom persistence or recurrence defined as treatment failure. RESULTS: Of 77 cases of UP in Japanese children reported since 1972, initial surgical treatment was performed in 42 cases (55%) and nonsurgical treatment in 35 cases (45%)...
December 23, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27973698/acute-intoxication-due-to-wisteria-floribunda-seed-in-seven-young-children
#8
Dongwan Kim, Jihyoung Park, Yun Mi Kim, Hann Tchah
BACKGROUND: Wisteria floribunda (W. floribunda) is a vine commonly found in Korea, Japan, and US. The objective of this observational study is to assess the toxicity of W. floribunda seed in young children. METHODS: Of 28 children in a kindergarten who participated in a field trip, seven ingested W. floribunda seeds, six half of the seed and one a whole seed. These seven children were admitted to the Gachon University Gil Medical Center [Incheon, Korea]. RESULTS: All of the children had vomiting within the four hours of ingesting the W...
December 14, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27935231/prolonged-tacrolimus-use-for-pediatric-gastrointestinal-disorder-a-double-edged-sword
#9
Kenji Hosoi, Katsuhiro Arai, Kentaro Matsuoka, Hirotaka Shimizu, Koichi Kamei, Atsuko Nakazawa, Toshiaki Shimizu, Julian Tang, Shuichi Ito
BACKGROUND: Although tacrolimus (TAC) appeared useful in inducing remission in children with refractory inflammatory bowel disease (IBD) or autoimmune gastroenteropathy (AGE), its use in maintenance therapy remains controversial. The aim of this study was to reveal the potential nephrotoxic nature of prolonged TAC use. METHODS: This retrospective study reviews children with gastrointestinal disorder who underwent kidney biopsy for the evaluation of renal damage during TAC therapy of over one year...
December 9, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27935218/is-there-a-relationship-between-neonatal-sepsis-and-simple-minor-neurological-dysfunction
#10
Nazan Kavas, Ayşe Engin Arısoy, Asuman Bayhan, Bülent Kara, Ayla Günlemez, Gülcan Türker, Meral Oruç, Ayşe Sevim Gökalp
BACKGROUND: This study examined potential risk factors for and consequences of simple minor neurological dysfunction (SMND), in a group of very low birth weight newborns followed until preschool age. METHODS: This is a prospective longitudinal study. Children with a birth weight below 1,500 g were assessed at 4 to 6 years of age. Twenty eight children with a normal neurological examination and 35 children with simple minor neurological dysfunction were included in the final analysis...
December 9, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27935152/intellectual-outcomes-of-extremely-preterm-infants-at-school-age
#11
Maya Asami, Atsushi Kamei, Misato Nakakarumai, Satoko Shirasawa, Manami Akasaka, Nami Araya, Sachiko Tanifuji, Shoichi Chida
BACKGROUND: The survival rate of extremely preterm (EP) infants (<28 weeks of gestation) has improved dramatically, and there is great interest in their long-term prognoses. This study aims to elucidate the influence of prenatal and postnatal care on long-term intellectual outcomes in EP infants. METHODS: Subjects were EP infants who were admitted to our neonatal intensive care unit from 1982 to 2005. The survival rate and neurodevelopmental outcomes at 6 years of age were analyzed for the periods of 1982-1991 (period 1) and 1992-2005 (period 2)...
December 9, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27914210/randomized-controlled-trial-of-oral-immunotherapy-for-egg-allergy-in-japanese-patients
#12
Masayuki Akashi, Hiroki Yasudo, Masami Narita, Ichiro Nomura, Akira Akasawa, Motohiro Ebisawa, Takao Takahashi, Yukihiro Ohya
BACKGROUND: Egg allergy is one of the most common food allergies in young child. While oral immunotherapy (OIT) is not routinely recommended in current guidelines, it has been considered as a potential alternative treatment strategy. Studies on OIT for food allergies have been explored; however, no studies with control group have been reported in Japan. METHODS: The first oral food challenge test (OFC) was performed on participants before treatment to ensure the diagnosis and evaluate the threshold dose for egg by the way of double-blind, placebo-controlled food challenge (DBPCFC)...
December 3, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27914182/positive-feelings-during-pregnancy-early-feeding-practices-and-infant-health
#13
Melissa A McManus, Ali A Khalessi, Joyce Lin, Jahanzeb Ashraf, Stephanie M Reich
BACKGROUND: Early parenting practices, like infant feeding, can impact children's physical health. Additionally, negative prenatal maternal affect can influence feeding choices, like breastfeeding, and can have a detrimental effect on children's health. However, little is known about the contribution of positive maternal affect during pregnancy on feeding practices and children's health. METHOD: This study explored whether positive prenatal feelings influenced children's health during the first 18 months, and whether early feeding practices mediated the relationship between these two variables...
December 3, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27880031/increased-levels-of-plasma-soluble-human-leukocyte-antigen-g-in-persistent-wheezy-infants
#14
Fulya Tahan, Hatice Eke Gungor, Himmet Haluk Akar, Berkay Saraymen
BACKGROUND: Human leukocyte antigen (HLA)-G is a non-classical major histocompatibility complex (MHC) class I antigen characterized by limited polymorphism in its coding region, unique tissue expression pattern in physiologic conditions and immunomodulatory properties. Recently, many studies suggest that the levels of sHLA-G were higher in atopic asthma and allergic rhinitis (AR). However, this remains to be uncertain in wheezy infants. In the present study, it was aimed to determine sHLA-G levels in wheezy infants...
November 23, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27875021/lifestyle-and-bowel-movements-in-school-children-results-from-the-toyama-birth-cohort-study
#15
Masaaki Yamada, Michikazu Sekine, Takashi Tatsuse
BACKGROUND: Constipation is prevalent health disorder and it has been bothering many pediatricians as well as people suffering from constipation. There have been few epidemiological surveys about constipation in Japanese children. This study aims to evaluate the prevalence of non-daily bowel movements (BM) and irregular BM among children and to identify modifiable lifestyle factors relevant to their bowel habits. METHODS: Subjects were from the Toyama Birth Cohort Study in Japan...
November 22, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27862707/pharmacotherapy-in-patients-with-pediatric-cipo-a-nationwide-survey-in-japan
#16
Naoki Hashizume, Minoru Yagi, Kosuke Ushijima, Yoshitaka Seki, Suguru Fukahori, Mitsuru Muto, Hiroshi Matsufuji, Tomoaki Taguchi
PURPOSE: Chronic intestinal pseudo-obstruction (CIPO) is a rare disabling and life-threatening disorder characterized by a severe impairment of gastrointestinal peristalsis. With respect to pharmacotherapy, while a number of agents have been developed, only a few trials have attempted to improve the pathological condition of patients with CIPO. This report presents the actual findings of pharmacotherapy in the patients with pediatric CIPO from the view point of a nationwide survey on the actual situation in Japan...
November 12, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27862704/what-happens-to-children-who-move-off-the-autism-spectrum-a-clinical-follow-up-study
#17
Nahit Motavalli Mukaddes, Tuba Mutluer, Basak Ayik, Ayla Umut
OBJECTIVES: There is controversial information on school age outcome of individuals who lose the diagnosis of autism and achieve "optimal outcome" (OO). The present study aimed to assess the autism symptoms and other psychiatric disorders in a group of children with a past history of autism. METHODS: The study includes individuals (n=26) who lost the diagnosis of autism two to eight years previously. Clinical assessment was done with both parents and children. DSM-V criteria were used for diagnosis of ASD...
November 12, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27862664/-neonatal-outcomes-in-a-level-ii-regional-neonatal-intensive-care-unit
#18
Raid M R Umran, Asjad Al-Jammali
BACKGROUND: Improving the neonatal mortality is a challenge in developing countries like Iraq. Increasing demands and overload of maternity services can considerably limit the improvement in neonatal outcomes. We aimed to document the numbers, disease patterns and outcomes of admitted newborns and the improvement after implementing clinical protocols and to identify possible future target measures. METHOD: A descriptive study was conducted at neonatal intensive care unit (NICU) at a regional hospital from 2011 to 2013...
November 12, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27809389/epidemiology-clinical-characteristics-and-genetic-etiology-of-neonatal-diabetes-in-japan
#19
Kazuaki Nagashima, Daisuke Tanaka, Nobuya Inagaki
Neonatal diabetes mellitus (NDM) is a rare but potentially devastating metabolic disorder, with reported incidence of one per 300,000-500,000 births generally, and hyperglycemia develops within the first 6 months of life (1-4). NDM is classified into two categories clinically. One is transient NDM (TNDM), in which insulin secretion is spontaneously recovered by several months of age, but sometimes recurs later, and the other is permanent NDM (PNDM), requiring lifelong medication. Recent molecular analysis of NDM identified at least 12 genetic abnormalities: chromosome 6q24, KCNJ11, ABCC8, INS, FOXP3, GCK, IPF1, PTF1A, EIF2AK3, GLUT2, HNF1β, and GLIS3 (5-22)...
November 3, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27805301/effects-of-deletion-polymorphism-in-ugt2b17-gene-on-prognosis-in-pediatric-cancer
#20
Sae Ishimaru, Yuza Yuki, Takashi Kaneko, Mitsuyoshi Urashima
BACKGROUND: The UDP-glucuronosyltransferase 2 family, polypeptide B17 (UGT2B17) gene encodes an enzyme that modifies carcinogens, C19 steroids, xenobiotics, and anticancer chemotherapeutic agents by glucuronidation. Pediatric cancers are much more sensitive to anticancer agents than adult cancers. Therefore, we examined the effects of a deletion polymorphism in the UGT2B17 gene on prognosis in pediatric cancer. METHODS: A total of 145 DNA samples were collected from children with malignant diseases...
November 2, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
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