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Pediatrics International: Official Journal of the Japan Pediatric Society

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https://www.readbyqxmd.com/read/29143423/treatment-and-biology-of-pediatric-acute-lymphoblastic-leukemia
#1
REVIEW
Motohiro Kato, Atsushi Manabe
Acute lymphoblastic leukemia (ALL) is the most common pediatric malignancy. In the past ALL was intractable but now the survival probability is as high as 80-90%. Improved supportive care, treatment stratification based on relapse risk, biological features of leukemic cells, and optimization of treatment regimens by nationwide and international collaboration have contributed to this dramatic improvement. While including traditional risk factors (e.g., age and leukocyte count at diagnosis), the treatment has been modified based on biological characteristics (aneuploidy and translocation) and treatment response (assessed by minimal residual disease)...
November 16, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29110414/clinical-characteristics-of-schoolchildren-with-renal-glucosuria
#2
Tastuhiko Urakami, Midori Yoda, Kei Yoshida, Yusuke Mine, Masako Aoki, Junichi Suzuki
BACKGROUND: We have conducted an annual urine glucose screening program at schools, and diagnosed schoolchildren with diabetes at an early stage of the disease. We also identified some cases with renal glucosuria (RG), based on positive urine glucose with normal glucose tolerance. METHODS: During the period from 2000 to 2015, 3, 309, 631 schoolchildren participated in the screening program. The positive rate for glucosuria in the first test was approximately 0.1%, whereas in the second test it was approximately 0...
November 7, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29105243/performance-of-multiplex-fusion-gene-testing-in-pediatric-acute-myeloid-leukemia
#3
Yuka Iijima-Yamashita, Hidemasa Matsuo, Miho Yamada, Takao Deguchi, Nobutaka Kiyokawa, Akira Shimada, Akio Tawa, Hiroyuki Takahashi, Daisuke Tomizawa, Takashi Taga, Akitoshi Kinoshita, Souichi Adachi, Keizo Horibe
BACKGROUND: Gene abnormalities, particularly chromosome rearrangements generating gene fusions, are associated with clinical characteristics and prognosis in pediatric acute myeloid leukemia (AML). Karyotyping is generally performed to enable risk stratification; however, the results are not always consistent with those generated by reverse transcription-polymerase chain reaction (RT-PCR), and more accurate and rapid methods are required. METHODS: A total of 487 samples from de novo AML patients enrolled in the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG) AML-05 study (n = 448), and acute promyelocytic leukemia (APL) patients enrolled in the JPLSG AML-P05 study (n = 39) were available for this investigation...
November 4, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29095541/cumulative-incidence-of-kawasaki-disease-in-japan
#4
Yosikazu Nakamura, Mayumi Yashiro, Maho Yamashita, Namiko Aoyama, Ushio Otaki, Yukie Ozeki, Takashi Sano, Takao Kojo, Ryusuke Ae, Yasuko Aoyama, Nobuko Makino, Kazuhiko Kotani
BACKGROUND: Although the nationwide surveys of Kawasaki disease (KD) in Japan have revealed the incidence rates of KD in this country, cumulative incidences, e.g., the proportion of those with a history of KD among general population of 10-year-old, are currently unknown. In this study we observed the cumulative incidence of KD in Japan. METHODS: Using the age- and sex-specific incidence rate of KD in Japan from the results of the nationwide surveys, incidence probabilities, which was the age-specific number of KD patients divided by the population used in the vital statistics, and cumulative proportions of not affected by KD till the end of 9-year-old of age were calculated...
November 2, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29095536/increased-serum-cortisol-levels-on-oral-food-challenge-in-infants-with-fpies
#5
Masaki Shimomura, Yasunori Ito, Hiroki Tanaka, Takaaki Meguro, Mitsuaki Kimura
BACKGROUND: An increase in absolute neutrophil count (ANC) is seen after an oral food challenge test (OFC) in patients with food protein-induced enterocolitis syndrome (FPIES). Although it has been suggested that interleukin (IL)-8 is involved in this phenomenon, a possible role for cortisol has not yet been studied. METHODS: Six OFCs with positive responses in 5 patients with FPIES due to cows' milk (CM) proteins and 2 OFCs with negative responses in 2 patients suspected of FPIES were analyzed...
November 2, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29068108/evaluation-of-sustained-tachyarrhythmia-in-children-younger-than-one-year-of-age
#6
Gulhan Tunca Sahin, Erkut Ozturk, Taner Kasar, Alper Guzeltas, Yakup Ergul
BACKGROUND: In this study, we aim to evaluate the results of non-operational sustained tachyarrhythmias in patients younger than 1 year of age in our center. METHODS: Between November 2010 and November 2016, the demographic characteristics, type and localization of the tachyarrhythmia, echocardiographic findings, and medical and/or ablation therapies applied for patients under 1 year of age who had sustained tachyarrhythmias were evaluated. RESULTS: Among 99 patients, 91 had sustained supraventricular tachycardia, and eight had sustained ventricular tachycardia...
October 25, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29068106/clinical-profile-of-congenital-rubella-syndrome-in-yogyakarta-indonesia
#7
Elisabeth S Herini, Gunadi, Agung Triono, Fita Wirastuti, Kristy Iskandar, Niprida Mardin, Yati Soenarto
BACKGROUND: Congenital rubella syndrome (CRS) has many severe neurological manifestations and other systemic consequences in patients. Although various studies have been done in Indonesia, there have not been any conclusive results on CRS incidence. Therefore, we aimed to investigate the incidence, clinical manifestations and outcomes of CRS in Yogyakarta, Indonesia. METHODS: A descriptive study involving a review of congenital anomalies associated with CRS cases at Dr...
October 25, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29067751/monitoring-of-fusion-gene-transcripts-to-predict-relapses-in-pediatric-acute-myeloid-leukemia
#8
Hidemasa Matsuo, Yuka Iijima-Yamashita, Miho Yamada, Takao Deguchi, Nobutaka Kiyokawa, Akira Shimada, Akio Tawa, Daisuke Tomizawa, Takashi Taga, Akitoshi Kinoshita, Souichi Adachi, Keizo Horibe
BACKGROUND: In acute myeloid leukemia (AML), accurate detection of minimal residual disease (MRD) enables better risk-stratified therapy. However, there are few studies monitoring multiple fusion transcripts and evaluating their accuracy as MRDs at multiple timepoints. METHODS: We retrospectively examined RNA obtained from 82 pediatric AML patients enrolled in the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG) AML-05 study. The expression of six important fusion transcripts (AML1(RUNX1)-ETO, CBFB-MYH11, MLL(KMT2A)-AF9, MLL-ELL, MLL-AF6, and FUS-ERG) was analyzed at five timepoints 30-40 days apart following diagnosis...
October 25, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29067750/quality-of-life-of-biliary-atresia-after-living-donor-liver-transplant-in-japan
#9
Ryota Kikuchi, Koichi Mizuta, Taizen Urahashi, Yukihiro Sanada, Naoya Yamada, Erika Onuma, Iori Sato, Kiyoko Kamibeppu
BACKGROUND: Health-related quality of life (HRQOL) is an important outcome in solid organ transplantation. This study evaluated and explored the factors of generic and transplant-specific HRQOL in Japanese pediatric and adolescent patients with biliary atresia (BA) after living donor liver transplant (LDLT). METHODS: A cross-sectional survey using anonymous questionnaires was completed between April and July 2015. Patients' medical records were accessed. The Japanese version of Pediatric Quality of Life Inventory(™) Generic Core Scales and Transplant Modules (child self-report and parent proxy-report) was administered...
October 25, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29059493/perinatal-helicopter-ambulance-service-at-wakayama-medical-university-hospital-a-14-year-review
#10
Takeshi Kumagai, Mitsuhiko Riko, Masashi Satoh, Nobuyuki Kakimoto, Takuya Sugimoto, Mina Ueda, Takahiro Okutani, Ryuzo Higuchi, Shigetaka Yagi, Sawako Minami, Asumi Higa, Masakazu Miyawaki, Hiroyuki Suzuki
BACKGROUND: In 2003, a perinatal helicopter air ambulance service was introduced for remote areas of Wakayama and Mie prefectures, Japan. However, its long-term impact on perinatal medicine has not yet been analyzed. METHODS: A retrospective observational study was conducted on helicopter air ambulance cases recorded between January 2003 and December 2016 at Wakayama Medical University Hospital (WMUH). RESULTS: During that period, 61 pregnant mothers were transferred by helicopter air ambulance to WMUH...
October 23, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29059487/from-childhood-adversity-to-problem-behaviors-role-of-psychological-and-structural-social-integration
#11
Lo-Hsin Chao, Chung-Ying Lin, Meng-Che Tsai, Ya-Lun Liang, Carol Strong
BACKGROUND: Childhood adversities (CAs) have been found to be associated with problem behaviors in adolescents; however, the mediators-that help build resilience and prevent some children who experience CAs from engaging in problem behaviors-await more exploration, including social integration. The aim of this study is to identify the association between CAs and adolescent problem behaviors, and to further examine the mediating role of social integration distinctly as psychological and structural integration...
October 23, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29059480/renal-insufficiency-mimicking-glutaric-acidemia-type-1-in-newborn-screening
#12
Masaaki Matsumoto, Hiroyuki Awano, Ryosuke Bo, Masashi Nagai, Kazumi Tomioka, Masahiro Nishiyama, Takeshi Ninchouji, Hiroaki Nagase, Mariko Yagi, Ichiro Morioka, Yuki Hasegawa, Yasuhiro Takeshima, Kazumoto Iijima
BACKGROUND: Glutaryl carnitine (C5DC) in dried blood spots is used as a biomarker for glutaric aciduria type 1 (GA-1) screening. Since C5DC is the only screening marker for this condition, various pathological conditions may interfere with C5DC metabolism. Recently, it has been reported that cases of renal insufficiency showed C5DC elevation. METHOD: Five cases who were positive for GA-1 via newborn screening using tandem mass spectrometry from September 2012 to March 2015 in our institute were enrolled in this study...
October 23, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29044906/long-term-follow-up-of-a-massive-conservatively-treated-splenic-infarction-in-a-young-adolescent
#13
Gabriella D'Angelo, Lucia Marseglia, Tiziana Russo, Eloisa Gitto, Pietro Impellizzeri
No abstract text is available yet for this article.
October 18, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29032597/more-than-two-years-follow-up-of-infants-with-congenital-cytomegalovirus-infection-in-japan
#14
Shin Koyano, Ichiro Morioka, Akira Oka, Hiroyuki Moriuchi, Kimisato Asano, Yushi Ito, Tetsushi Yoshikawa, Hideto Yamada, Tatsuo Suzutani, Naoki Inoue
BACKGROUND: The aim of the study was to evaluate outcomes of congenital cytomegalovirus (CMV) cases identified by our urine-filter screening assay after follow-up for more than 2 years, and to observe the clinical outcomes after anti-CMV therapies. METHODS: Sixty of the 72 congenital CMV cases were enrolled. Forty-three cases asymptomatic at birth, 7 cases symptomatic at birth but untreated with anti-CMV drugs, and 10 symptomatic cases treated with anti-CMV drugs were clinically observed for more than 2 years...
October 15, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28972299/subcutaneous-chest-wall-abscess-as-a-complication-of-bcg-vaccination
#15
Taketo Otsuka, Ryosuke Hosokai, Toru Watanabe, Naruhiko Ishiwada, Akihiko Saitoh
No abstract text is available yet for this article.
October 3, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28960680/low-risk-of-treatment-resistance-in-down-syndrome-with-kawasaki-disease
#16
Shinichi Takatsuki, Shohei Ogata, Masahiro Ishii, Masato Yokozawa, Masae Ono, Masako Fujiwara, Hiroyuki Ida, Hideki Motomura, Hiroyuki Moriuchi, Mio Taketazu, Yoichi Kawamura, Tatsuya Kawano, Tatsuro Izumi, Junko Shiono, Shiro Tsuchiya, Keiji Tsuchiya, Terufumi Goushi, Fukiko Ichida, Tsutomu Saji
BACKGROUND: Japanese nationwide survey reported that Down syndrome (DS) is less-frequently occurring comorbidity in Kawasaki disease (KD). Although altered immune responses are frequently observed in DS, no studies have focused treatment response and risk for coronary artery abnormalities (CAAs) in DS with KD. The aim of this study was to evaluate clinical manifestations, treatment response and proportion of CAAs in DS with KD. METHODS: We retrospectively reviewed the medical records of DS with KD from 2005 through 2012...
September 27, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28940983/changes-in-trends-and-impact-of-testing-for-influenza-in-infants-with-fever-under-90-days-of-age
#17
Suji Kim, Hye Min Moon, Joon Kee Lee, Kyuyol Rhie, Ki Wook Yoon, Eun Hwa Choi, Hoan Jong Lee, Hyunju Lee
BACKGROUND: Infants less than 90 days who present with fever are commonly subject to various invasive procedures due to risk of bacterial infections in this age group. However a great proportion are due to viral infections, including influenza. The aim of this study was to assess the impact of testing influenza in infants < 90 days with fever as well as analyze the subjects' characteristics to identify which infants should be considered for such testing. METHODS: Clinical characteristics and trends in influenza virus testing and treatment were analyzed among febrile infants <90 days who came to the emergency room and were diagnosed with influenza during 2005 to 2015...
September 22, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28901668/dilatation-of-the-ductus-arteriosus-by-diazoxide-in-fetal-and-neonatal-rats
#18
Katsuaki Toyoshima, Kazuo Momma, Tetsuko Ishii, Toshio Nakanishi
BACKGROUND: Diazoxide, an ATP-sensitive potassium channel opener, is the main therapeutic agent for treating hyperinsulinemic hypoglycemia. We aimed to determine the in vivo ductus-dilating effects of diazoxide in fetal and neonatal rats. METHODS: Near-term rat pups delivered via a cesarean section were housed at 33°C. After rapid whole-body freezing, The ductus arteriosus (DA) diameter was measured using a microscope and a micrometer. Full-term pregnant rats (gestational day 21) were intraperitoneally injected with diazoxide (10 and 100 mg/kg) 4 h before delivery, and the neonatal DA diameter was measured at 0, 30, or 60 min after birth...
September 13, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28892213/evaluation-of-longitudinal-and-radial-left-ventricular-functions-using-two-and-three-dimensional-echocardiography-before-and-after-intravenous-immunoglobulin-administration-in-patients-with-acute-kawasaki-disease
#19
Ikuo Hashimoto, Yu Saitou, Nao Sakata, Ko Shibata
BACKGROUND: The relationship between left ventricular (LV) function and longitudinal or radial contraction has not yet been elucidated in patients with acute Kawasaki disease (KD), especially before and after intravenous immunoglobulin (IVIG) administration. METHODS: We studied 28 KD patients without coronary aneurysms (average 3.2 years). The LV end-diastolic volume (LVEDV), end-systolic volume (LVESV), stroke volume (LVSV), and ejection fraction (LVEF) were assessed using three-dimensional echocardiography before IVIG, after IVIG administration, and in the convalescent phase...
September 11, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28892211/early-menarche-is-associated-with-non-alcoholic-fatty-liver-disease-in-adulthood
#20
Kyung Hee Yi, Jin Soon Hwang, Se Won Lim, Jun Ah Lee, Dong Ho Kim, Jung Sub Lim
BACKGROUND: The aim of this study was to examine the association between early menarche (<12 years) and non-alcoholic fatty liver disease (NAFLD) in premenopausal women and to explore whether it is mediated by adult obesity and insulin resistance. METHODS: We analyzed data of premenopausal women, aged 15 or older, from the Korea National Health and Nutrition Examination Survey (2007-2009). We divided the women into 3 groups: early menarche, reference (12.00-15...
September 11, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
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