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Reports of Practical Oncology and Radiotherapy

Kh Haddad, O Anjak, B Yousef
Aim: The thermal neutron, epithermal neutron and high-energy photon fluence were measured in this work around the Varian 21EX 23 MV CLINAC, which is operated in Albairouni hospital in Damascus, Syria. Background: Photoneutron measurements around medical CLINAC aim to protect both patients and staff from unwanted radiation. Materials and methods: Neutron and photon activation techniques were applied using gold foils. Results: It was found that high-energy photons fluence has practically a constant value in the field size...
January 2019: Reports of Practical Oncology and Radiotherapy
Joana Spaggiari Marra, Guilherme Paulão Mendes, Gerson Hiroshi Yoshinari, Flávio da Silva Guimarães, Suleimy Cristina Mazin, Harley Francisco de Oliveira
Background: High-grade gliomas (HGGs) are a heterogeneous disease group, with variable prognosis, inevitably causing deterioration of the quality of life. The estimated 2-year overall survival is 20%, despite the best trimodality treatment consisting of surgery, chemotherapy, and radiotherapy. Aim: To evaluate long-term survival outcomes and factors influencing the survival of patients with high-grade gliomas treated with radiotherapy. Materials and methods: Data from 47 patients diagnosed with high-grade gliomas between 2009 and 2014 and treated with three-dimensional radiotherapy (3DRT) or intensity-modulated radiotherapy (IMRT) were analyzed retrospectively...
January 2019: Reports of Practical Oncology and Radiotherapy
Paweł Czajkowski, Tomasz Piotrowski
Purpose: The aim of this study is to present a short and comprehensive review of the methods of medical image registration, their conditions and applications in radiotherapy. A particular focus was placed on the methods of deformable image registration. Methods: To structure and deepen the knowledge on medical image registration in radiotherapy, a medical literature analysis was made using the Google Scholar browser and the medical database of the PubMed library...
January 2019: Reports of Practical Oncology and Radiotherapy
Krzysztof Ślosarek, Iwona Brąclik, Wojciech Leszczyński, Joanna Kopczyńska, Wojciech Osewski, Jacek Wendykier
Aim: The aim of this study is to answer the question whether the calculated dose distributions for HD and Millennium collimators (Varian Medical Systems) are equivalent for large treatment volumes. Background: Modern biomedical linacs are equipped with multileaf collimators where leaves can be of different widths. Thinner leaves allow better fit to desired (tumor) shape. At the same time, however, the maximum size of the field that can be obtained with the collimator is also reduced...
January 2019: Reports of Practical Oncology and Radiotherapy
Somayeh Taghizadeh, Cecille Labuda, Claus Chunli Yang, Bart Morris, Madhava R Kanakamedala, Srinivasan Vijayakumar, Roberto Rey-Dios, William N Duggar, Edward Florez, Ali Fatemi
Aim: Development of MRI sequences and processing methods for the production of images appropriate for direct use in stereotactic radiosurgery (SRS) treatment planning. Background: MRI is useful in SRS treatment planning, especially for patients with brain lesions or anatomical targets that are poorly distinguished by CT, but its use requires further refinement. This methodology seeks to optimize MRI sequences to generate distortion-free and clinically relevant MR images for MRI-only SRS treatment planning...
January 2019: Reports of Practical Oncology and Radiotherapy
Mansour Ashoor, Abdollah Khorshidi, Leila Sarkhosh
Aim: One of the most important microvasculatures' geometrical variables is number of pores per capillary length that can be evaluated using MRI. The transportation of blood from inner to outer parts of the capillary is studied by the pores and the relationship among capillary wall thickness, size and the number of pores is examined. Background: Characterization of capillary space may obtain much valuable information on the performance of tissues as well as the angiogenesis...
January 2019: Reports of Practical Oncology and Radiotherapy
Antonio Cassio Assis Pellizzon
No abstract text is available yet for this article.
January 2019: Reports of Practical Oncology and Radiotherapy
Cristina Prieto, Isabel Linares
The current treatment for brain tumors, such as glioblastoma multiforme (GBM), has not been developed enough yet in order to fully heal them. The main causes are the lack of specificity of the treatments, the difficulty of passage of drugs through the blood-brain barrier, heterogeneity and tumor aggressiveness, and widespread dissemination in the brain. The application of nanoparticles (Nps) have been a breakthrough for both diagnostic imaging and targeted therapies. There have been numerous studies with different types of Nps in brain tumors, but we have focused on thermosensitive liposomes, which are characterized by releasing the chemotherapeutic agent included within its lipophilic membranes through heat...
September 2018: Reports of Practical Oncology and Radiotherapy
Bagher Farhood, Hadi Samadian, Mahdi Ghorbani, Seyed Salman Zakariaee, Courtney Knaup
Neutron capture therapy (NCT) is a targeted radiotherapy for cancer treatment. In this method, neutrons with a spectra/specific energy (depending on the type of agent used for NCT) are captured with an agent that has a high cross-section with these neutrons. There are some agents that have been proposed in NCT including 10 B, 157 Gd and 33 S. Among these agents, only 10 B is used in clinical trials. Application of 157 Gd is limited to in-vivo and in-vitro research. In addition, 33 S has been applied in the field of Monte Carlo simulation...
September 2018: Reports of Practical Oncology and Radiotherapy
Paola Villegas-Otiniano, Jimena Vásquez-Medina, Vicente Aleixandre Benites-Zapata
The incidence of multiple primary neoplasms has been increasing over the years. Within this group, the coexistence of primary prostate cancer and primary colorectal cancer is one of the most frequent. The objective of this case report is to present the case of a 76-year-old male patient who presented the diagnosis of prostate cancer and synchronous rectal cancer. To this end, his clinical history in the oncological service of the Hospital Militar Central del Perú (tertiary hospital) has been reviewed.
September 2018: Reports of Practical Oncology and Radiotherapy
Bhattasali Onita, Thompson Lester D R, Abdalla Iman A, Chen Jergin, Iganej Shawn
AIM: To perform a comparison of Cisplatin vs. Cetuximab in p16-positive oropharyngeal squamous cell carcinoma (OPSCC) in the context of the revised HPV-based staging. BACKGROUND: Previous reports comparing these agents in head and neck cancer have included heterogenous disease and p16-status. MATERIALS AND METHODS: A retrospective review was conducted from 2006 to 2016 of patients with p16-positive OPSCC who underwent definitive radiotherapy concurrent with either triweekly Cisplatin ( n  = 251) or Cetuximab ( n  = 40)...
September 2018: Reports of Practical Oncology and Radiotherapy
Tomohei Nakao, Hiroko Fukushima, Takashi Fukushima, Ryoko Suzuki, Sho Hosaka, Yuni Yamaki, Chie Kobayashi, Atsushi Iwabuchi, Kazuo Imagawa, Aiko Sakai, Toko Shinkai, Kouji Masumoto, Shingo Sakashita, Tomohiko Masumoto, Masashi Mizumoto, Ryo Sumazaki, Hideyuki Sakurai
Aim: To assess the feasibility of transferring to the University of Tsukuba Hospital for proton beam therapy (PBT) during intensive chemotherapy in children with Ewing sarcoma family of tumors (ESFT) who had been diagnosed and started their first-line treatment at prefectural or regional centers for pediatric oncology. Background: The treatment of ESFT relies on a multidisciplinary approach using intensive neoadjuvant and adjuvant chemotherapies with surgery and radiotherapy...
September 2018: Reports of Practical Oncology and Radiotherapy
Ladan Rezaee
Aim: Design of a numerical method for creating spread-out Bragg peak (SOBP) and evaluation of the best parameter in Bortfeld Model to this aim in oxygen ion therapy. Background: In radiotherapy, oxygen ions have more biological benefits than light beams. Oxygen ions have a higher linear energy transfer (LET) and larger relative biological effectiveness (RBE) than lighter ones. Materials and methods: For the design of the spread-out Bragg peak (SOBP) for oxygen beam, we designed a numerical method using the Geant4 Monte Carlo simulation code, along with matrix computations...
September 2018: Reports of Practical Oncology and Radiotherapy
Toshiro Tsubouchi, Masashi Yagi, Iori Sumida, Keisuke Tamari, Yuji Seo, Kazuhiko Ogawa
Aim: To evaluate the influence of the beam shape created by X-rays with "flat beams" and without "flattening-filter-free [FFF] beams" a flattening filter, and the isocenter locations for FFF beams on the treatment of a large irradiated volume for tumours. Background: The increase of dose rate and the decrease of out-of-field dose can be expected for FFF beams and lead to effective and safety radiotherapy. On the other hand, the bell-shaped dose profile is thought to be a factor of negating these advantages...
September 2018: Reports of Practical Oncology and Radiotherapy
Roger Cai Xiang Soh, Guan Heng Tay, Wen Siang Lew, James Cheow Lei Lee
Aim: To identifying depth dose differences between the two versions of the algorithms using AIP CT of a 4D dataset. Background: Motion due to respiration may challenge dose prediction of dose calculation algorithms during treatment planning. Materials and methods: The two versions of depth dose calculation algorithms, namely, Anisotropic Analytical Algorithm (AAA) version 10.0 (AAAv10.0), AAA version 13.6 (AAAv13.6) and Acuros XB dose calculation (AXB) algorithm version 10...
September 2018: Reports of Practical Oncology and Radiotherapy
Celine Clerkin, Sinead Brennan, Laura M Mullaney
Aim: The aim of this research is to establish if variation exists in the dose delivered for head and neck (HN) localisation computed tomography (CT) imaging in radiation therapy (RT); to propose a national diagnostic reference levels (DRLs) for this procedure and to make a comparison between the national DRL and a DRL of a European sample. Background: CT has become an indispensable tool in radiotherapy (RT) treatment planning. It is a requirement of legislation in many countries that doses of ionising radiation for medical exposures be kept 'As Low As Reasonably Achievable'...
September 2018: Reports of Practical Oncology and Radiotherapy
Beata Sas-Korczynska, Marian Reinfuss, Jerzy W Mitus, Elzbieta Pluta, Anna Patla, Tomasz Walasek
Objectives: Radiotherapy in patients with sinonasal mucosal melanoma (SNMM) was given as alternative treatment to surgery in cases with advanced, inoperable tumors or those not eligible for surgery. We presented the outcomes for patients with SNMM treated with radiotherapy alone. Material and methods: The retrospective review of 6 consecutive SNMM (nasal cavity - 4 pts. and paranasal sinus - 2 pts.) patients (3 males and 3 females at mean age 64 years) treated between 2008 and 2016 was presented...
September 2018: Reports of Practical Oncology and Radiotherapy
Shuhei Sekii, Yoshinori Ito, Ken Harada, Mayuka Kitaguchi, Kana Takahashi, Koji Inaba, Naoya Murakami, Hiroshi Igaki, Ryohei Sasaki, Jun Itami
Aim: To investigate the intrafraction movement of the esophagus using fiducial markers. Background: Studies on intrafraction esophageal motion using the fiducial markers are scarce. Materials and methods: We retrospectively analyzed patients with clinical T1N0 esophageal cancer who had received fiducial markers at our hospital between July 2007 and December 2013. Real-Time Position Management System to track the patient's respiration was used, and each patient underwent three-dimensional computed tomography of the resting expiratory and inspiratory level...
September 2018: Reports of Practical Oncology and Radiotherapy
Miguel Ángel Souto-Del Bosque, Miguel Ángel Cervantes-Bonilla, Gerardo Del Carmen Palacios-Saucedo
Aim: To identify clinical and dosimetric factors associated with the development of hematologic toxicity (HT) for cervical cancer (CC) treated with chemotherapy and 3D conformal radiotherapy. Background: Chemoradiotherapy is the standard of care management for CC patients with IB2-IVA clinical stages (CS). This treatment carries toxicities, standing out the one that occurs at the hematologic level. Subjects and methods: CC patients with IB2-IVA CS treated with chemotherapy and 3D conformal radiotherapy (50 Gy) plus Brachyterapy (7 Gy x3 or 9 Gy x2) at our institution between March 2016 and March 2017...
September 2018: Reports of Practical Oncology and Radiotherapy
Tarcisio Passos Ribeiro de Campos, Bruno M Mendes, Bruno Trindade, Wagner L Araujo
Aim: The present study evaluated the increment of cardiac risk (CR) and absorbed dose in radiotherapy of the internal mammary chain (IMC), in particular with photon portals of 4 6 MV, and cobalt therapy (Co60); and, electron portals of 8, 12 and 16 MeV applied in the left breast, considering the adoption of a combined photon (16 Gy) and electron (30 Gy) protocols. Materials and methods: The modified ICRP-reference female model of 60 kg, 163 cm and 43 years of age, coil RCP-AF, was modelled...
September 2018: Reports of Practical Oncology and Radiotherapy
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