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Reports of Practical Oncology and Radiotherapy

Daisuke Kawahara, Shuichi Ozawa, Takeo Nakashima, Shintaro Tsuda, Yusuke Ochi, Takuro Okumura, Hirokazu Masuda, Kazunari Hioki, Tathsuhiko Suzuki, Yoshimi Ohno, Tomoki Kimura, Yuji Murakami, Yasushi Nagata
Aim and background: IGRT based on bone matching may produce a large target positioning error in terms of the reproducibility of expiration breath-holding on SBRT for liver cancer. We evaluated the intrafractional and interfractional errors using the diaphragm position at the end of expiration by utilising Abches and analysed the factor of the interfractional error. Materials and methods: Intrafractional and interfractional errors were measured using a couple of frontal kV images, planning computed tomography (pCT) and daily cone-beam computed tomography (CBCT)...
March 2018: Reports of Practical Oncology and Radiotherapy
Kycler Witold, Kubiak Anna, Trojanowski Maciej, Janowski Jakub
Colorectal cancer is the second most common type of cancer both in Europe and Poland. During the last 30 years more than a 3-fold increase has been observed in Poland due to environmental and genetic factors. Almost all colorectal malignancies are related to the formation and malignant transformation of colorectal dysplasia and adenoma. Efforts aiming to decrease the number of colorectal cancer deaths are focused on the disease early detection. Genetic diagnosis for hereditary syndromes predisposing to colorectal cancer has been developed and is a part of the routine treatment...
March 2018: Reports of Practical Oncology and Radiotherapy
Ana Cravo Sá, Ana Fermento, Dalila Neves, Sara Ferreira, Teresa Silva, Carina Marques Coelho, Aude Vaandering, Ana Roma, Sérgio Quaresma, Emmanuel Bonnarens
Aim: In this study, we intend to compare two different setup procedures for female breast cancer patients. Background: Imaging in radiotherapy provides a precise localization of the tumour, increasing the accuracy of the treatment delivery in breast cancer. Materials and methods: Twenty breast cancer patients who underwent whole breast radiotherapy (WBRT) were selected for this study. Patients were divided into two groups of ten. Group one (G1) was positioned by tattoos and then the patient positioning was adjusted with the aid of AlignRT (Vision RT, London, UK)...
January 2018: Reports of Practical Oncology and Radiotherapy
Ramya Rangarajan
Aim: The aim of the study is to evaluate the differences in dosimetry between tandem-ovoid and tandem-ring gynaecologic brachytherapy applicators in image based brachytherapy. Background: Traditionally, tandem ovoid applicators were used to deliver dose to tumor in intracavitary brachytherapy. Tandem-ring, tandem-cylinder and hybrid intracavitary, interstitial applicators are also used nowadays in cervical cancer brachytherapy. Methods and materials: 100 CT datasets of cervical cancer patients (stage IB2 - IIIB) receiving HDR application (50 tandem-ovoid and 50 tandem-ring) were studied...
January 2018: Reports of Practical Oncology and Radiotherapy
Daisuke Kawahara, Shuichi Ozawa, Akito Saito, Tomoki Kimura, Tatsuhiko Suzuki, Masato Tsuneda, Sodai Tanaka, Kazunari Hioki, Takeo Nakashima, Yoshimi Ohno, Yuji Murakami, Yasushi Nagata
Aim: Lipiodol was used for stereotactic body radiotherapy combining trans arterial chemoembolization. Lipiodol used for tumour seeking in trans arterial chemoembolization remains in stereotactic body radiation therapy. In our previous study, we reported the dose enhancement effect in Lipiodol with 10× flattening-filter-free (FFF). The objective of our study was to evaluate the dose enhancement and energy spectrum of photons and electrons due to the Lipiodol depth with flattened (FF) and FFF beams...
January 2018: Reports of Practical Oncology and Radiotherapy
Elham Hosseinzadeh, Nooshin Banaee, Hassan Ali Nedaie
Aim: The aim of this study is to calculate neutron contamination at the presence of circular cones irradiating by 18 MV photons using Monte Carlo code. Background: Small photon fields are one of the most useful methods in radiotherapy. One of the techniques for shaping small photon beams is applying circular cones made of lead. Using this method in high energy photon due to neutron contamination is a crucial issue. Materials and methods: Initially, Varian linac producing 18 MV photons was simulated and after validating the code, various circular cones were also simulated...
January 2018: Reports of Practical Oncology and Radiotherapy
Michał Falco, Bartłomiej Masojć, Marta Milchert-Leszczyńska, Andrzej Kram
Background: Accelerated partial breast irradiation (APBI) is a promising method of adjuvant radiotherapy for select patients. Intraoperative radiotherapy (IORT) is a form of APBI, and appropriate patient selection is important. Aim: The aim of our study was to analyse the influence of our protocol on the frequency of WBRT after IORT and our protocol's correlation with the reported use of WBRT according to TARGIT guidelines. We also aimed to verify how changes in our protocol influenced the frequency of WBRT...
January 2018: Reports of Practical Oncology and Radiotherapy
Hidekazu Tanaka, Takahiro Yamaguchi, Kae Hachiya, Shingo Kamei, Satoshi Ishihara, Masahide Hayashi, Shinichi Ogawa, Hironori Nishibori, Satoshi Goshima, Masayuki Matsuo
Aim: This study aimed to evaluate the treatment result of intensity-modulated radiation therapy (IMRT) in a large number of Japanese patients with prostate cancer. Background: A total of 1091 patients with localized prostate cancer were recruited between March 2006 and July 2014. The patients were stratified into low- (n = 205 [18.8%]), intermediate- (n = 450 [41.2%]), high- (n = 345 [31.6%]), and very high-risk (n = 91 [8.3%]) groups according to the National Comprehensive Cancer Network classification...
January 2018: Reports of Practical Oncology and Radiotherapy
Evgeny V Khmelevsky, Irina N Kancheli, Vladimir S Khoroshkov, Andrey D Kaprin
Aim: This study evaluated the frequency and long-term dynamics of early and late post irradiation damage after proton-photon or photon therapy for locally advanced prostate cancer. Background: The results of a randomized study of proton-photon or photon therapy using several fractionation regimes were analyzed in 272 patients with high and intermediate risk of progression. Materials and methods: Three variants of proton boost fractionation were studied sequentially: 3...
January 2018: Reports of Practical Oncology and Radiotherapy
Yury O Nunez Lopez, Berta Victoria, Pawel Golusinski, Wojciech Golusinski, Michal M Masternak
Aim: To characterize the miRNA expression profile in head and neck squamous cell carcinoma (HNSSC) accounting for a broad range of cancer subtypes and consequently identify an optimal miRNA signature with prognostic value. Background: HNSCC is consistently among the most common cancers worldwide. Its mortality rate is about 50% because of the characteristic aggressive behavior of these cancers and the prevalent late diagnosis. The heterogeneity of the disease has hampered the development of robust prognostic tools with broad clinical utility...
January 2018: Reports of Practical Oncology and Radiotherapy
Taylan Tuğrul
Aim: In this study, at different fields, energies and gantry angles, treatment couch and rails dose absorption ratio and treatment couch effect on surface and build-up region doses were examined. Background: It is assumed that radiation attenuation is minimal because the carbon fiber couches have low density and it is not generally accounted for during treatment planning. Consequently, it leads to a major dosimetric mistake. Materials and methods: Solid water phantom was used for relative dose measurement...
January 2018: Reports of Practical Oncology and Radiotherapy
Osamu Tanaka, Hisao Komeda, Mitsuyoshi Hattori, Shigeki Hirose, Eiichi Yama, Masayuki Matsuo
Aim: Prostate contouring using CT alone is difficult. To overcome the uncertainty, CT/MRI registration using a fiducial marker is generally performed. However, visualization of the marker itself can be difficult with MRI. This study aimed to determine the optimal MRI pulse sequence for defining the marker as well as the prostate outline among five sequences. Materials and methods: A total of 21 consecutive patients with prostate cancer were enrolled. Two gold fiducial markers were placed before CT/MRI examination...
November 2017: Reports of Practical Oncology and Radiotherapy
Whitney A Sumner, Arya Amini, Todd C Hankinson, Nicholas K Foreman, Laurie E Gaspar, Brian D Kavanagh, Sana D Karam, Chad G Rusthoven, Arthur K Liu
Aim/Background: Papillary meningioma represents a rare subset of World Health Organization (WHO) Grade III meningioma that portends an overall poor prognosis. There is relatively limited data regarding the benefit of postoperative radiation therapy (PORT). We used the National Cancer Data Base (NCDB) to compare overall survival (OS) outcomes of surgically resected papillary meningioma cases undergoing PORT compared to post-operative observation. Materials and methods: The NCDB was queried for patients with papillary meningioma, diagnosed between 2004 and 2013, who underwent upfront surgery with or without PORT...
November 2017: Reports of Practical Oncology and Radiotherapy
Ravindra Shende, Ganesh Patel
AIM: Objective of present study is to determine optimum value of DLG and its validation prior to being incorporated in TPS for Varian TrueBeam™ millennium 120 leaves MLC. BACKGROUND: Partial transmission through the rounded leaf ends of the Multi Leaf Collimator (MLC) causes a conflict between the edges of the light field and radiation field. Parameter account for this partial transmission is called Dosimetric Leaf Gap (DLG). The complex high precession technique, such as Intensity Modulated Radiation Therapy (IMRT), entails the modeling of optimum value of DLG inside Eclipse Treatment Planning System (TPS) for precise dose calculation...
November 2017: Reports of Practical Oncology and Radiotherapy
Suman Das, Yogaraja Dorairaja, Anandakrishnan Kuppusamy
Adenoid cystic carcinoma is a very rare malignancy commonly originating from the salivary glands of the head and neck. It is again very scantily seen in sites like the bronchus. Surgical resection is the mainstay of treatment but many a times the tumour site and size preclude a favourable outcome of surgery and the patient is advised for other forms of local treatment like Radiotherapy. Here, we present a case report of a young female with primary adenoid cystic carcinoma of the bronchus. The tumour was located in the carina and the left bronchus which was obstructing the airway resulting in collapse of the left lung, this resulted in shifting the mediastinum and abdominal structures in to the thorax...
November 2017: Reports of Practical Oncology and Radiotherapy
Hidekazu Tanaka, Takahiro Yamaguchi, Kae Hachiya, Masahide Hayashi, Shinichi Ogawa, Hironori Nishibori, Shingo Kamei, Satoshi Ishihara, Masayuki Matsuo
AIM: To assess the changes in prostate size in patients with prostate cancer undergoing intensity-modulated radiation therapy (IMRT). BACKGROUND: The effect of size change produced by IMRT is not well known. MATERIALS AND METHODS: We enrolled 72 patients who received IMRT alone without androgen-deprivation therapy and underwent magnetic resonance imaging (MRI) examination before and after IMRT. The diameter of the entire prostate in the anterior-posterior (P-AP) and left-right (P-LR) directions was measured...
November 2017: Reports of Practical Oncology and Radiotherapy
Seyed Mohammad Mahdi Abtahi, Seyed Mahmoud Reza Aghamiri, Masoumeh Yadolahi, Aziz Mahmoudzadeh
AIM: The purpose of the present study is to investigate the dependence of micronuclei response on the depth of absorbed dose. BACKGROUND: One of the most common cytogenetic methods used for radiation dosimetry is micronuclei (MN). Being less complex and faster than other methods are two remarkable advantages of the MN method which make it suitable for monitoring of population. In biological dosimetry based on the micronuclei method, the investigation into the dependence of response on the depth in which dose is absorbed is significant, though has received less attention so far...
November 2017: Reports of Practical Oncology and Radiotherapy
Samir Abdallah Hanna, Ana Luisa Garcia Calich, Artur Katz, Isidio Calich, Gustavo Gibin Duarte, José Luiz Barbosa Bevilacqua
This article provides description about acute toxicity and early follow-up of one patient treated for breast cancer and Schnitzler syndrome. There are no previously reported cases exploring this interaction on medical literature. The expected radiodermitis to occur in the region treated with radiotherapy along with urticarial-like lesions might be challenging in view of the interaction between symptoms and therapeutic measures.
November 2017: Reports of Practical Oncology and Radiotherapy
James C L Chow
Recent rapid development of Internet-based computer technologies has made possible many novel applications in radiation dose delivery. However, translational speed of applying these new technologies in radiotherapy could hardly catch up due to the complex commissioning process and quality assurance protocol. Implementing novel Internet-based technology in radiotherapy requires corresponding design of algorithm and infrastructure of the application, set up of related clinical policies, purchase and development of software and hardware, computer programming and debugging, and national to international collaboration...
November 2017: Reports of Practical Oncology and Radiotherapy
Breno A Rocha, Lucianne M C Lima, Lívia M R Paranaíba, Angel da S Martinez, Maria Betânia de O Pires, Edimilson M de Freitas, Camilla V Vilas Boas, Mário R de Melo Filho
AIM: To fabricate and evaluate the efficacy of individualized intraoral stents to minimize the potential side effects of radiation on oral tissues in patients with early stages of lip cancer. BACKGROUND: Lower lip cancer is a common tumor found almost exclusively in middle-aged and elderly males. Surgery is the most common treatment of choice, although for less extensive lesions, exclusive radiotherapy may be preferred. Some studies have found that the use of intraoral stents in patients with intraoral cancer (e...
November 2017: Reports of Practical Oncology and Radiotherapy
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