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Reports of Practical Oncology and Radiotherapy

Lalida Tuntipumiamorn, Puangpen Tangboonduangjit, Taweap Sanghangthum, Rattapol Rangseevijitprapa, Chirasak Khamfongkhruea, Thida Niyomthai, Boonrut Vuttiprasertpong, Supranee Supanant, Nongnuch Chatchaipaiboon, Porntip Iampongpaiboon, Pitchayut Nakkrasae, Tanwiwat Jaikuna
Aim: In this study, an accuracy survey of intensity-modulated radiation therapy (IMRT) and volumetric arc radiation therapy (VMAT) implementation in radiotherapy centers in Thailand was conducted. Background: It is well recognized that there is a need for radiotherapy centers to evaluate the accuracy levels of their current practices, and use the related information to identify opportunities for future development. Materials and methods: An end-to-end test using a CIRS thorax phantom was carried out at 8 participating centers...
January 2019: Reports of Practical Oncology and Radiotherapy
Kennya Medeiros L de B Lima, Allan A Lima Pereira, Thiago B de Freitas, Saulo Brito Silva, Heloisa de Andrade Carvalho, Max S Mano, Gustavo Nader Marta
Background/Aim: Post-operative radiation therapy (PORT) is associated with improvement in loco-regional control and survival rates in early breast cancer. However, the evidence of benefit in patients after treatment with neoadjuvant chemotherapy (NAC) is poor. We aimed to assess the impact of the type of surgery in the PORT plan and the role of the PORT fields in clinical outcomes in breast cancer patients who had undergone NAC followed by surgery. Materials and methods: We performed a retrospective analysis of all non-metastatic breast cancer patients treated between 2008 and 2014 at our institution who had received NAC and PORT...
January 2019: Reports of Practical Oncology and Radiotherapy
Duong Thanh Tai, Luong Thi Oanh, Nguyen Dong Son, Truong Thi Hong Loan, James C L Chow
Aim: The aim of this study is to verify the Prowess Panther jaws-only intensity modulated radiation therapy (JO-IMRT) treatment planning (TP) by comparing the TP dose distributions for head-and-neck (H&N) cancer with the ones simulated by Monte Carlo (MC). Background: To date, dose distributions planned using JO-IMRT for H&N patients were found superior to the corresponding three-dimensional conformal radiotherapy (3D-CRT) plans. Dosimetry of the JO-IMRT plans were also experimentally verified using an ionization chamber, MapCHECK 2, and Octavius 4D and good agreements were shown...
January 2019: Reports of Practical Oncology and Radiotherapy
Jessica Prunaretty, Pierre Boisselier, Norbert Aillères, Olivier Riou, Sebastien Simeon, Ludovic Bedos, David Azria, Pascal Fenoglietto
Background: The management of breath-induced tumor motion is a major challenge for lung stereotactic body radiation therapy (SBRT). Three techniques are currently available for these treatments: tracking (T), gating (G) and free-breathing (FB). Aim: To evaluate the dosimetric differences between these three treatment techniques for lung SBRT. Materials and methods: Pretreatment 4DCT data were acquired for 10 patients and sorted into 10 phases of a breathing cycle, such as 0% and 50% phases defined respectively as the inhalation and exhalation maximum...
January 2019: Reports of Practical Oncology and Radiotherapy
Matthew Hoffmann, Jacqueline Pacey, Josie Goodworth, Andrea Laszcyzk, Richard Ford, Brendon Chick, Stuart Greenham, Justin Westhuyzen
Aim: To assess a class solution template for volumetric-modulated arc therapy (VMAT) for prostate cancer using plan analysis software. Background: VMAT is a development of intensity-modulated radiotherapy (IMRT) with potential advantages for the delivery of radiotherapy (RT) in prostate cancer. Class solutions are increasingly used for facilitating RT planning. Plan analysis software provides an objective tool for evaluating class solutions. Materials and methods: The class solution for VMAT was based on the current static field IMRT template...
January 2019: Reports of Practical Oncology and Radiotherapy
Ignacio Morales-Orue, Rodolfo Chicas-Sett, Pedro C Lara
Over the last decade, immunotherapy has emerged as a hopeful alternative in cancer therapy. Different drugs are used to stimulate the immune system and block negative immune regulatory pathways, known as "immune checkpoint inhibitors (ICI)". Although clinical studies have reported efficacy and safety with the use of ICI, only a small group of patients have obtained a clinical benefit. Because of this, immunomodulation based on immunogenic cell death produced by radiotherapy (RT) has been well positioned as an alternative to increase the clinical effect on the primary neoplasm, but also in distant tumours, a phenomenon known as the "abscopal effect"...
January 2019: Reports of Practical Oncology and Radiotherapy
Ramya Rangarajan, Saravanan Subramanian, Kalyani Gopalakrishnan, Vijayalakshmi Jothi, Kumari Krishnamurthy
Aim: The aim of this study is to analyse the dosimetry to the pelvic lymph nodes and its correlation to point B using CT based high dose rate brachytherapy of carcinoma cervix. Background: Conventionally, dose to pelvic lymph nodes from intracavitary brachytherapy was reported by point B and by the reference points of the lymphatic trapezoid. Materials and methods: 30 consecutive CT based high dose rate applications were reviewed between February and March 2016...
January 2019: Reports of Practical Oncology and Radiotherapy
Shun Lu, Xinhao Peng, Bingwen Zou, Cheng Zhou, Mei Feng, Jinyi Lang
Aim: The aim of this study was to confirm whether patients with sacral chordoma benefit from adjuvant radiotherapy and to determine the optimal photon radiotherapy module for comprehensive treatment. Background: Chordoma is a rare slow-growing neoplasm arisen from cellular remnants of the notochord. About 50% occur in the sacrococcygeal region. Surgical resection and adjuvant radiation therapy are recommended treatment due to the improving local control rate. Materials and methods: 118 patients treated by surgery and adjuvant radiotherapy from August 2003 to May 2015 were retrospectively analyzed...
January 2019: Reports of Practical Oncology and Radiotherapy
Agnieszka Skrobala, Marta Adamczyk, Aldona Karczewska-Dzionk
Aim: To present a proposed gastric cancer intensity-modulated radiotherapy (IMRT) treatment planning protocol for an institution that have not introduced volumetric modulated arc therapy in clinical practice. A secondary aim was to determine the impact of 2DkV set-up corrections on target coverage and organ at risk (OAR). Methods and Materials: Twenty consecutive patients were treated with a specially-designed non-coplanar 7-field IMRT technique. The isocenter-shift method was used to estimate the impact of 2DkV-based set-up corrections on the original base plan (BP) coverage...
January 2019: Reports of Practical Oncology and Radiotherapy
Gustavo R Sarria, Miguel Ángel Berenguer Francés, Isabel Linares Galiana
Amongst all efforts for improving oncological management outcomes, nanoparticles enhanced radiation for breast cancer patient's treatment is a novel approach that has grown interest for research in the last decade. Multiple preclinical data has been published, from all around the globe; however, clinical evidence is still insufficient for implementing the method in routine practice and in disease specific management. Gold nanoparticles (AuNP), which may be among the most studed materials, account for the majority of available data; however, some new materials have also been used in preclinical settings...
January 2019: Reports of Practical Oncology and Radiotherapy
Rut Cañas, Isabel Linares, Ferran Guedea, Miguel Ángel Berenguer
Radiological Oncology, like the rest of medical specialties, is beginning to provide can personalized therapies. The ongoing scientific advances enable a great degree of precision in diagnoses and therapies. To fight cancer, from a radiotherapy unit, requires up-to-date equipment, professionals with different specialties working in synchrony (doctors, physicists, biologists, etc.) and a lot of research. Some of the new therapeutic tendencies are immunotherapy, nanoparticles, gene therapy, biomarkers, artificial intelligence, etc...
January 2019: Reports of Practical Oncology and Radiotherapy
Salvatore Cozzi, Andrea Slocker Escarpa, Daniel Lorenzo Parra, Dina Najjari Jamal, Josep Maria Caminal Mitjana, Josep Maria Piulats R, Ferran Guedea Edo, Cristina Gutierrez Miguelez
Introduction: Uveal melanoma is a rare tumour caused by genetic factors and alterations in the immune response. Inflammatory bowel disease (IBD) is a multifactorial chronic inflammatory disorder characterized by an inappropriate or excessive immune response. The two main types of IBD are Crohn's disease (CD) and ulcerative colitis (UC). A diagnosis of IBD and the use of immunosuppressive drugs are both independently associated with an increased risk of developing skin melanoma. The association between IBD and uveal melanoma (UM) has not been previously described...
January 2019: Reports of Practical Oncology and Radiotherapy
Fernando Lopez-Campos, Danielle Candini, Eliseo Carrasco, Miguel Angel Berenguer Francés
Aim: In recent years, we have seen a considerable increase in the relevance of nanostructures for the safe delivery of therapeutic agents and their capacity as an immunomodulatory tool. Materials and methods: Potential clinical applications related to their unique structural properties have been described in the evolving landscape of immunotherapy. Results: This review briefly summarizes the evidence for the role of nanoparticles in regulating the immune response...
January 2019: Reports of Practical Oncology and Radiotherapy
Kh Haddad, O Anjak, B Yousef
Aim: The thermal neutron, epithermal neutron and high-energy photon fluence were measured in this work around the Varian 21EX 23 MV CLINAC, which is operated in Albairouni hospital in Damascus, Syria. Background: Photoneutron measurements around medical CLINAC aim to protect both patients and staff from unwanted radiation. Materials and methods: Neutron and photon activation techniques were applied using gold foils. Results: It was found that high-energy photons fluence has practically a constant value in the field size...
January 2019: Reports of Practical Oncology and Radiotherapy
Joana Spaggiari Marra, Guilherme Paulão Mendes, Gerson Hiroshi Yoshinari, Flávio da Silva Guimarães, Suleimy Cristina Mazin, Harley Francisco de Oliveira
Background: High-grade gliomas (HGGs) are a heterogeneous disease group, with variable prognosis, inevitably causing deterioration of the quality of life. The estimated 2-year overall survival is 20%, despite the best trimodality treatment consisting of surgery, chemotherapy, and radiotherapy. Aim: To evaluate long-term survival outcomes and factors influencing the survival of patients with high-grade gliomas treated with radiotherapy. Materials and methods: Data from 47 patients diagnosed with high-grade gliomas between 2009 and 2014 and treated with three-dimensional radiotherapy (3DRT) or intensity-modulated radiotherapy (IMRT) were analyzed retrospectively...
January 2019: Reports of Practical Oncology and Radiotherapy
Paweł Czajkowski, Tomasz Piotrowski
Purpose: The aim of this study is to present a short and comprehensive review of the methods of medical image registration, their conditions and applications in radiotherapy. A particular focus was placed on the methods of deformable image registration. Methods: To structure and deepen the knowledge on medical image registration in radiotherapy, a medical literature analysis was made using the Google Scholar browser and the medical database of the PubMed library...
January 2019: Reports of Practical Oncology and Radiotherapy
Krzysztof Ślosarek, Iwona Brąclik, Wojciech Leszczyński, Joanna Kopczyńska, Wojciech Osewski, Jacek Wendykier
Aim: The aim of this study is to answer the question whether the calculated dose distributions for HD and Millennium collimators (Varian Medical Systems) are equivalent for large treatment volumes. Background: Modern biomedical linacs are equipped with multileaf collimators where leaves can be of different widths. Thinner leaves allow better fit to desired (tumor) shape. At the same time, however, the maximum size of the field that can be obtained with the collimator is also reduced...
January 2019: Reports of Practical Oncology and Radiotherapy
Somayeh Taghizadeh, Cecille Labuda, Claus Chunli Yang, Bart Morris, Madhava R Kanakamedala, Srinivasan Vijayakumar, Roberto Rey-Dios, William N Duggar, Edward Florez, Ali Fatemi
Aim: Development of MRI sequences and processing methods for the production of images appropriate for direct use in stereotactic radiosurgery (SRS) treatment planning. Background: MRI is useful in SRS treatment planning, especially for patients with brain lesions or anatomical targets that are poorly distinguished by CT, but its use requires further refinement. This methodology seeks to optimize MRI sequences to generate distortion-free and clinically relevant MR images for MRI-only SRS treatment planning...
January 2019: Reports of Practical Oncology and Radiotherapy
Mansour Ashoor, Abdollah Khorshidi, Leila Sarkhosh
Aim: One of the most important microvasculatures' geometrical variables is number of pores per capillary length that can be evaluated using MRI. The transportation of blood from inner to outer parts of the capillary is studied by the pores and the relationship among capillary wall thickness, size and the number of pores is examined. Background: Characterization of capillary space may obtain much valuable information on the performance of tissues as well as the angiogenesis...
January 2019: Reports of Practical Oncology and Radiotherapy
Antonio Cassio Assis Pellizzon
No abstract text is available yet for this article.
January 2019: Reports of Practical Oncology and Radiotherapy
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