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Reports of Practical Oncology and Radiotherapy

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https://www.readbyqxmd.com/read/28515675/utility-of-intraoral-stents-in-external-beam-radiotherapy-for-head-and-neck-cancer
#1
Hiroshi Doi, Masao Tanooka, Toshihisa Ishida, Kuniyasu Moridera, Kenji Ichimiya, Kazuo Tarutani, Kazuhiro Kitajima, Masayuki Fujiwara, Hiromitsu Kishimoto, Norihiko Kamikonya
AIM: This study aimed to assess the utility and stability of intraoral stent during intensity-modulated radiation therapy (IMRT). BACKGROUND: The benefits of intraoral stents in radiotherapy are unclear. MATERIALS AND METHODS: We analyzed 386 setup errors in 12 patients who received IMRT for head and neck cancers without intraoral stents (intraoral stent [-]) and 183 setup errors in 6 patients who received IMRT with intraoral stents (intraoral stent [+])...
July 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28507460/validation-of-the-liver-mean-dose-in-terms-of-the-biological-effective-dose-for-the-prevention-of-radiation-induced-liver-damage
#2
Hiroshi Doi, Norihisa Masai, Kenji Uemoto, Osamu Suzuki, Hiroya Shiomi, Daisaku Tatsumi, Ryoong-Jin Oh
AIM: The purpose of this study was to determine the optimal mean liver biologically effective dose (BED) to prevent radiation-induced liver disease (RILD) in stereotactic body radiation therapy (SBRT). BACKGROUND: The actual mean doses appropriate for liver irradiation in modern radiotherapy techniques have not been adequately investigated, although SBRT is sometimes alternatively performed using fractionated regimens. MATERIALS AND METHODS: SBRT treatment plans for liver tumors in 50 patients were analyzed...
July 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28507459/spironolactone-ameliorates-the-cardiovascular-toxicity-induced-by-concomitant-trastuzumab-and-thoracic-radiotherapy
#3
Guler Yavas, Esin Celik, Cagdas Yavas, Cagdas Elsurer, Rengin Elsurer Afsar
AIM: We aimed to evaluate impact of spironolactone (S) on cardiovascular toxicity of concomitant use of radiotherapy (RT) and trastuzumab (T). BACKGROUND: S, an aldosterone receptor antagonist, is known to ameliorate the cardiac damage. S ameliorates anthracycline -induced cardiotoxicity, there is no data regarding to effect of S on both T and radiation-induced cardiotoxicity. MATERIALS/METHODS: Eighty rats were divided into eight groups: group (G) 1 was defined as control group...
July 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28507458/effect-of-tumor-amplitude-and-frequency-on-4d-modeling-of-vero4drt-system
#4
Hideharu Miura, Shuichi Ozawa, Masahiro Hayata, Shintaro Tsuda, Kiyoshi Yamada, Yasushi Nagata
BACKGROUND: An important issue in indirect dynamic tumor tracking with the Vero4DRT system is the accuracy of the model predictions of the internal target position based on surrogate infrared (IR) marker measurement. We investigated the predictive uncertainty of 4D modeling using an external IR marker, focusing on the effect of the target and surrogate amplitudes and periods. METHODS: A programmable respiratory motion table was used to simulate breathing induced organ motion...
July 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28507457/evaluating-the-performance-of-tg-43-protocol-in-esophageal-hdr-brachytherapy-viewpoint-to-trachea-inhomogeneity
#5
Seyed Mohsen Hosseini Daghigh, Hamid Reza Baghani, Seyed Mahmoud Reza Aghamiri, Seyed Rabi Mahdavi
AIM: The aim of this study is to evaluate the effect of air within trachea on dose calculations of esophageal HDR brachytherapy treatment planning. BACKGROUND: Dose calculations in esophageal HDR brachytherapy treatment planning systems are greatly based on TG-43 protocol which in all materials are considered to be water equivalent. MATERIALS AND METHODS: A cylindrical PMMA phantom with a tube in the center (neck equivalent phantom) accompanied by Flexitron HDR brachytherapy system was used in this study...
July 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28507456/adjuvant-intraoperative-radiotherapy-for-selected-breast-cancers-in-previously-irradiated-women-evidence-for-excellent-feasibility-and-favorable-outcomes
#6
Gladys Blandino, Marina Guenzi, Liliana Belgioia, Elisabetta Bonzano, Elena Configliacco, Elena Tornari, Francesca Cavagnetto, Davide Bosetti, Alessandra Fozza, Daniele Friedman, Renzo Corvò
BACKGROUND: The present report provides preliminary outcomes with intraoperative radiotherapy delivered to women with breast cancer included in a re-irradiation program. MATERIALS AND METHODS: From October 2010 to April 2014, thirty women were included in a re-irradiation protocol by exploiting IORT technique. The median time between the two irradiations was 10 years (range 3-50). All patients underwent conservative surgery, sentinel lymph node excision and IORT with electron beam delivered by a mobile linear accelerator...
July 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28507455/neoadjuvant-chemoradiotherapy-of-the-rectal-carcinoma-the-correlation-between-the-findings-on-the-restaging-multiparametric-3t-mri-scanning-and-the-surgical-findings
#7
Radovan Vojtíšek, Eva Korčáková, Jan Mařan, Ondřej Šorejs, Jindřich Fínek
AIM: To figure out how to correlate the findings on functional MRI and carried out after neoadjuvant CRT of rectal carcinoma with final histology after surgery. BACKGROUND: Neoadjuvant CRT is the standard treatment of locally advanced rectal carcinoma. Its use leads to the downstaging of the disease and in 15-42% of patients even to the detection of pCR after TME. The use of functional MRI improves the sensitivity and specificity of pCR detection up to 52-64% and 89-98%, respectively...
July 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28479875/evaluation-of-cone-beam-computed-tomography-image-quality-assurance-for-vero4drt-system
#8
Hideharu Miura, Shuichi Ozawa, Masahiro Hayata, Shintarou Tsuda, Tsubasa Enosaki, Kiyoshi Yamada, Yasushi Nagata
We report the characteristics of quality assurance (QA) image for Vero4DRT system with a kilo-voltage (kV) cone-beam computed tomography (CBCT) capability to perform image-guided radiation therapy (IGRT). To acquire a set of CBCT, the kV source is rotated either 215° clockwise (CW) (tube 1 from 5° to 220° and tube 2 from 275° to 130°) or counterclockwise (CCW) (tube 1 from 85° to 230° and tube 2 from 355° to 140°). Image geometry, image uniformity, high/low contrast resolutions, and contrast linearity were measured with a Catphan 504 CT phantom (The Phantom Laboratory, NY)...
May 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28479874/prognostic-correlation-of-cell-cycle-progression-score-and-ki-67-as-a-predictor-of-aggressiveness-biochemical-failure-and-mortality-in-men-with-high-risk-prostate-cancer-treated-with-external-beam-radiation-therapy
#9
Iván Henríquez López, David Parada, Pablo Gallardo, Marina Gascón, Arnau Besora, Karla Peña, Francesc Riu, Miquel Arquez Pianetta, Oscar Abuchaibe, Laura Torres Royò, Meritxell Arenas
OBJECTIVES: Ki-67 is a proliferation marker in prostate cancer. A prognostic RNA signature was developed to characterize prostate cancer aggressiveness. The aim was to evaluate prognostic correlation of CCP and Ki-67 with biochemical failure (BF), and survival in high-risk prostate cancer patients (pts) treated with radiation therapy (RT). METHODS: CCP score and Ki-67 were derived retrospectively from pre-treatment paraffin-embedded prostate cancer tissue of 33 men diagnosed from 2002 to 2006...
May 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28479873/comparison-of-surface-dose-delivered-by-7%C3%A2-mv-unflattened-and-6%C3%A2-mv-flattened-photon-beams
#10
Ashokkumar Sigamani, Arunai Nambiraj
AIM: The purpose of this study is to determine the central-axis dose in the buildup region and the surface dose delivered by a 6 MV flattened photon beam (6 MV-FB) and a higher energy unflattened (7 MV-FFF) therapeutic photon beam for different-sized square fields with open fields and modifying filters. MATERIALS AND METHODS: The beams are produced by a Siemens Artiste linear accelerator with a NACP-02 ionization chamber and the dose is measured by using GafChromic film and two different, commonly used, dosimeters: a p-type photon semiconductor dosimeter (PFD) and a cylindrical ionization chamber (CC13)...
May 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28461789/is-immunohistochemical-evaluation-of-p16-in-oropharyngeal-cancer-enough-to-predict-the-hpv-positivity
#11
Paweł Golusiński, Jakub Pazdrowski, Mateusz Szewczyk, Maciej Misiołek, Wioletta Pietruszewska, Janusz Klatka, Sławomir Okła, Henryk Kaźmierczak, Andrzej Marszałek, Violetta Filas, Augusto Schneider, Michał M Masternak, Katarzyna Stęplewska, Katarzyna Miśkiewicz-Orczyk, Wojciech Golusiński
AIM: Our goal was to determine the expression levels of p16 in the cohort of the OPSCC patients and evaluation of the pathological and clinical differences between these two groups including patients' survival. BACKGROUND: HPV infection is the main causative factor of oropharyngeal cancer (OPSCC). Identification of HPV status in OPSCC requires positive evaluation of viral DNA integration into host cell however, p16 accumulation in the proliferating cell layers has been accepted as an alternative marker for HPV infection...
May 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28461788/coping-with-loss-of-ability-vs-acceptance-of-disease-in-women-after-breast-cancer-treatment
#12
Katarzyna Cieślak, Wojciech Golusiński
AIM: To answer the question: is there a correlation between copying with the loss of ability and the acceptance of disease? BACKGROUND: The loss of ability is the beginning of a process of dealing with a widely understood dysfunction and its consequences. This happens owing to the lifting of the barriers that emerged due to the loss of ability and through the acquisition of skills that help an individual find their way in the new reality. MATERIALS AND METHODS: The study included 90 patients with history of breast cancer...
May 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28461787/dosimetric-impact-in-the-dose-volume-histograms-of-rectal-and-vesical-wall-contouring-in-prostate-cancer-imrt-treatments
#13
Laura Gómez, Carlos Andrés, Antonio Ruiz
AIM: The main purpose of this study was to evaluate the differences in dose-volume histograms of IMRT treatments for prostate cancer based on the delineation of the main organs at risk (rectum and bladder) as solid organs or by contouring their wall. BACKGROUND: Rectum and bladder have typically been delineated as solid organs, including the waste material, which, in practice, can lead to an erroneous assessment of the risk of adverse effects. MATERIALS AND METHODS: A retrospective study was made on 25 patients treated with IMRT radiotherapy for prostate adenocarcinoma...
May 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28461786/prospective-evaluation-of-anxiety-depression-and-quality-of-life-in-medically-inoperable-early-stage-non-small-cell-lung-cancer-patients-treated-with-stereotactic-ablative-radiotherapy
#14
Jacek Rutkowski, Magdalena Szymanik, Maciej Blok, Joanna Kozaka, Renata Zaucha
AIM: The aim of this prospective study was to evaluate the level of anxiety, depression, and quality of life (QoL) in medically inoperable patients with early stage non-small cell lung cancer (NSCLC) treated with stereotactic ablative radiotherapy (SABR). BACKGROUND: Prolonged survival is equally important as maintaining high QoL and good psychological functioning during the treatment of lung cancer. Nowadays available SABR has markedly changed clinical care and outcomes in the group of medically inoperable patients...
May 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28461785/estimation-of-peripheral-dose-from-co-60-beam-in-water-phantom-measured-in-secondary-standard-dosimetry-laboratory-pakistan
#15
Muhammad Shahban, Babar Hussain, Khalid Mehmood, Shakeel Ur Rehman
BACKGROUND: Peripheral or scatter dose harms neighbouring normal tissues during administration of dose to cancerous tissues, therefore, knowledge of peripheral dose is an important consideration in radiotherapy. AIM: In present study, absorbed dose measurements in a water phantom were performed for three field sizes, 7 × 7 cm(2), 10 × 10 cm(2) and 15 × 15 cm(2). MATERIALS AND METHODS: For each field size, dose was measured at six depths below the front surface of the water phantom; 2...
May 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28461784/retrospective-evaluation-of-the-effectiveness-of-radiotherapy-in-patients-with-plantar-fascitis-heel-spurs
#16
Piotr Kędzierawski, Rafał Stando, Paweł Macek
AIM: The aim of the study was the evaluation of the effectiveness of radiotherapy in patients with the feet pain caused by heel spurs. BACKGROUND: Treatment options for patients reporting these symptoms include use of suitable orthopedic footwear, the use of general or topical non-steroidal anti-inflammatory drugs or steroids, physiotherapy, manual therapy, shock wave or appropriate surgical procedures. Radiotherapy is one of the method used in patients with chronic pain syndrome...
May 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28461783/ct-and-mri-based-gross-target-volume-comparison-in-vestibular-schwannomas
#17
Bhudevi Soubhagya N Kulkarni, Harjot Bajwa, Mukka Chandrashekhar, Sunil Dutt Sharma, Rohith Singareddy, Dileep Gudipudi, Shabbir Ahmad, Alok Kumar, N V N Madusudan Sresty, Alluri Krishnam Raju
AIM: This study represents an enumeration and comparison of gross target volumes (GTV) as delineated independently on contrast-enhanced computed tomography (CT) and T1 and T2 weighted magnetic resonance imaging (MRI) in vestibular schwannomas (VS). BACKGROUND: Multiple imaging in radiotherapy improves target localization. METHODS AND MATERIALS: 42 patients of VS were considered for this prospective study with one patient showing bilateral tumor...
May 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28461782/the-semiconductor-diode-detector-response-as-a-function-of-field-size-and-beam-angle-of-high-energy-photons
#18
Tomasz Koper, Anna Kowalik, Sebastian Adamczyk
AIM: The measurements of semiconductor diode detector response as a function of field size and beam angle of high-energy photons. BACKGROUND: In vivo dosimetry plays an important role in the therapeutic process of the patient. Because of the different orientation of the beam relative to the patient and different sizes of irradiation fields, it is extremely important to take into account the response of the detector depending on the angle and the size of the beam...
May 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28490991/other-non-surgical-treatments-for-liver-cancer
#19
Paul Revel-Mouroz, Philippe Otal, Marion Jaffro, Antoine Petermann, Olivier Meyrignac, Pierre Rabinel, Fatima-Zohra Mokrane
Interventional radiology plays a major role in the modern management of liver cancers, in primary hepatic malignancies or metastases and in palliative or curative situations. Radiological treatments are divided in two categories based on their approach: endovascular treatment and direct transcapsular access. Endovascular treatments include mainly three applications: transarterial chemoembolization (TACE), transarterial radioembolization (TARE) and portal vein embolization (PVE). TACE and TARE share an endovascular arterial approach, consisting of a selective catheterization of the hepatic artery or its branches...
March 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28490990/management-of-liver-cancer-the-surgeon-s-point-of-view
#20
REVIEW
Pierre Rabinel, Damien Dousse, Fabrice Muscari, Bertrand Suc
During the last twenty years, a huge progress has been achieved in the treatment of liver cancer and recent strategies include interventional radiology, chemotherapy regimens and surgery. Meanwhile, Stereotactic Body Radiation Therapy (SRBT) has developed in the treatment of all organs with millimetre accuracy, very few side effects and a high control rate. So, SRBT has become a therapeutic weapon in his own right in liver tumour treatment. Many publications have reported encouraging results in colorectal liver metastasis, hepatocellular carcinoma on cirrhosis and peripheric cholangiocarcinoma...
March 2017: Reports of Practical Oncology and Radiotherapy
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