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Reports of Practical Oncology and Radiotherapy

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https://www.readbyqxmd.com/read/28951700/adaptive-radiotherapy-in-a-case-of-adenoid-cystic-carcinoma-of-bronchus-and-its-favourable-impact-on-treatment-outcome-a-case-report
#1
Suman Das, Yogaraja Dorairaja, Anandakrishnan Kuppusamy
Adenoid cystic carcinoma is a very rare malignancy commonly originating from the salivary glands of the head and neck. It is again very scantily seen in sites like the bronchus. Surgical resection is the mainstay of treatment but many a times the tumour site and size preclude a favourable outcome of surgery and the patient is advised for other forms of local treatment like Radiotherapy. Here, we present a case report of a young female with primary adenoid cystic carcinoma of the bronchus. The tumour was located in the carina and the left bronchus which was obstructing the airway resulting in collapse of the left lung, this resulted in shifting the mediastinum and abdominal structures in to the thorax...
November 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28951699/does-intensity-modulated-radiation-therapy-imrt-alter-prostate-size-magnetic-resonance-imaging-evaluation-of-patients-undergoing-imrt-alone
#2
Hidekazu Tanaka, Takahiro Yamaguchi, Kae Hachiya, Masahide Hayashi, Shinichi Ogawa, Hironori Nishibori, Shingo Kamei, Satoshi Ishihara, Masayuki Matsuo
AIM: To assess the changes in prostate size in patients with prostate cancer undergoing intensity-modulated radiation therapy (IMRT). BACKGROUND: The effect of size change produced by IMRT is not well known. MATERIALS AND METHODS: We enrolled 72 patients who received IMRT alone without androgen-deprivation therapy and underwent magnetic resonance imaging (MRI) examination before and after IMRT. The diameter of the entire prostate in the anterior-posterior (P-AP) and left-right (P-LR) directions was measured...
November 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28951698/dependence-of-micronuclei-assay-on-the-depth-of-absorbed-dose
#3
Seyed Mohammad Mahdi Abtahi, Seyed Mahmoud Reza Aghamiri, Masoumeh Yadolahi, Aziz Mahmoudzadeh
AIM: The purpose of the present study is to investigate the dependence of micronuclei response on the depth of absorbed dose. BACKGROUND: One of the most common cytogenetic methods used for radiation dosimetry is micronuclei (MN). Being less complex and faster than other methods are two remarkable advantages of the MN method which make it suitable for monitoring of population. In biological dosimetry based on the micronuclei method, the investigation into the dependence of response on the depth in which dose is absorbed is significant, though has received less attention so far...
November 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28932175/radiotherapy-for-a-breast-cancer-patient-with-schnitzler-syndrome-report-of-acute-toxicity-and-early-follow-up
#4
Samir Abdallah Hanna, Ana Luisa Garcia Calich, Artur Katz, Isidio Calich, Gustavo Gibin Duarte, José Luiz Barbosa Bevilacqua
This article provides description about acute toxicity and early follow-up of one patient treated for breast cancer and Schnitzler syndrome. There are no previously reported cases exploring this interaction on medical literature. The expected radiodermitis to occur in the region treated with radiotherapy along with urticarial-like lesions might be challenging in view of the interaction between symptoms and therapeutic measures.
November 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28932174/internet-based-computer-technology-on-radiotherapy
#5
REVIEW
James C L Chow
Recent rapid development of Internet-based computer technologies has made possible many novel applications in radiation dose delivery. However, translational speed of applying these new technologies in radiotherapy could hardly catch up due to the complex commissioning process and quality assurance protocol. Implementing novel Internet-based technology in radiotherapy requires corresponding design of algorithm and infrastructure of the application, set up of related clinical policies, purchase and development of software and hardware, computer programming and debugging, and national to international collaboration...
November 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28883766/intraoral-stents-in-preventing-adverse-radiotherapeutic-effects-in-lip-cancer-patients
#6
Breno A Rocha, Lucianne M C Lima, Lívia M R Paranaíba, Angel da S Martinez, Maria Betânia de O Pires, Edimilson M de Freitas, Camilla V Vilas Boas, Mário R de Melo Filho
AIM: To fabricate and evaluate the efficacy of individualized intraoral stents to minimize the potential side effects of radiation on oral tissues in patients with early stages of lip cancer. BACKGROUND: Lower lip cancer is a common tumor found almost exclusively in middle-aged and elderly males. Surgery is the most common treatment of choice, although for less extensive lesions, exclusive radiotherapy may be preferred. Some studies have found that the use of intraoral stents in patients with intraoral cancer (e...
November 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28883765/software-based-evaluation-of-a-class-solution-for-prostate-imrt-planning
#7
Sarah Clarke, Josie Goodworth, Justin Westhuyzen, Brendan Chick, Matthew Hoffmann, Jacqueline Pacey, Stuart Greenham
AIM: To use plan analysis software to evaluate a class solution for prostate intensity modulated radiotherapy (IMRT) planning. BACKGROUND: Class solutions for radiotherapy planning are increasingly being considered for streamlining planning. Plan analysis software provides an objective approach to evaluating radiotherapy plans. MATERIALS AND METHODS: Three iterations of a class solution for prostate IMRT planning (T1, T2 and Tfinal) were compared to the clinical plan of 74 prostate patients using radiotherapy plan analysis software (Plan IQ™, Sun Nuclear Corporation)...
November 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28883764/prognostic-significance-diagnosis-and-treatment-in-patients-with-gastric-cancer-and-positive-peritoneal-washings-a-review-of-the-literature
#8
REVIEW
Radosław Lisiecki, Małgorzata Kruszwicka, Arkadiusz Spychała, Dawid Murawa
Peritoneal dissemination is a common consequence of a relapse following a radical surgical treatment of gastric cancer. The development of the disease in the peritoneum depends not only on its stage, but also on free cancer cells exfoliated from the tumor mass or from involved lymph nodes, and which are capable of being implanted in the peritoneum. According to the latest TNM (7 edition; 2010) classification, patients with free cancer cells in the peritoneal washings qualify for stage IV of the disease. Patients in whom free cancer cells were found during the operation - have a recurrence of gastric cancer - mainly in the peritoneum, and the majority of them die within two years of the diagnosis...
November 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28883763/cyberknife-stereotactic-radiosurgery-and-denosumab-for-giant-cell-tumour-of-the-skull-base-case-report
#9
Cuauhtemoc de la Peña, Jorge H Guajardo, Maria F Gonzalez, Miguel A Hinojosa, Erick Cardona
Giant cell tumours (GCT) of the skull is a rare entity with only small number of cases reported in literature and optimal treatment is yet to be determined. These tumours have shown high recurrence rates after incomplete surgery, usually occurring during the first year. Even with new surgical techniques a complete resection in skull base tumours is not always possible without functional compromise. Therefore, adjuvant therapy is essential to enhance local control and quality of life. We report a rare case of a 34-year-old male with giant cell tumour (GCT) of the skull base involving the petrous bone, clivus and sphenoid body...
November 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28855853/evaluation-of-dose-calculations-accuracy-of-a-commercial-treatment-planning-system-for-the-head-and-neck-region-in-radiotherapy
#10
Mohammad Taghi Bahreyni Toossi, Bagher Farhood, Shokouhozaman Soleymanifard
AIM: The objective was to quantify dose calculation accuracy of TiGRT TPS for head and neck region in radiotherapy. BACKGROUND: In radiotherapy of head and neck cancers, treatment planning is difficult, due to the complex shape of target volumes and also to spare critical and normal structures. These organs are often very near to the target volumes and have low tolerance to radiation. In this regard, dose calculation accuracy of treatment planning system (TPS) must be high enough...
September 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28855852/influence-of-optimizing-protocol-choice-on-the-integral-dose-value-in-prostate-radiotherapy-planning-by-dynamic-techniques-pilot-study
#11
Anna Zaleska, Krzysztof Bogaczyk, Tomasz Piotrowski
AIM: The purpose of this study was to compare the values of integral dose, calculated for treatment plans of dynamic radiotherapy techniques prepared with two different optimization protocols. BACKGROUND: Delivering radiation by IMRT, VMAT and also HT techniques has an influence on the low dose deposition of large areas of the patient body. Delivery of low dose can induce injury of healthy cells. In this situation, a good solution would be to reduce the area, which receives a low dose, but with appropriate dose level for the target volume...
September 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28831281/improving-radiation-oncology-through-clinical-audits-introducing-the-iroca-project
#12
Maria Glòria Torras, Magdalena Fundowicz, Luisa Aliste, Esther Asensio, Anna Maria Boladeras, Josep Maria Borràs, Luísa Carvalho, Carla Castro, Letizia Deantonio, Ewelina Konstanty, Marco Krengli, Marta Kruszyna, Joana Lencart, Miquel Macià, Susanna Marín, Carles Muñoz-Montplet, Carla Pisani, Diana Pinto, Montserrat Puigdemont, Ferran Guedea, Artur Aguiar, Piotr Milecki, Julian Malicki
As radiotherapy practice and processes become more complex, the need to assure quality control becomes ever greater. At present, no international consensus exists with regards to the optimal quality control indicators for radiotherapy; moreover, few clinical audits have been conducted in the field of radiotherapy. The present article describes the aims and current status of the international IROCA "Improving Radiation Oncology Through Clinical Audits" project. The project has several important aims, including the selection of key quality indicators, the design and implementation of an international audit, and the harmonization of key aspects of radiotherapy processes among participating institutions...
September 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28831280/malignant-pleural-mesothelioma-pleural-cavity-irradiation-after-decortication-with-helical-tomotherapy
#13
Semi B Harrabi, Stefan A Koerber, Sebastian Adeberg, Sonja Katayama, Klaus Herfarth, Juergen Debus, Florian Sterzing
BACKGROUND: Malignant pleural mesothelioma (MPM) is a rare and aggressive disease that poses a treatment challenge in spite of recent technical developments. The aim of this retrospective analysis is to assess the feasibility of administering intensity-modulated radiotherapy (IMRT) to the pleural cavity using helical tomotherapy in patients who had undergone pleurectomy/decortication (P/D) and also the resulting toxicity levels. PATIENTS AND METHODS: Ten patients who had MPM and had undergone P/D were treated with pleural cavity irradiation that included a median dose of 52...
September 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28831279/setup-uncertainties-and-ptv-margins-at-different-anatomical-levels-in-intensity-modulated-radiotherapy-for-nasopharyngeal-cancer
#14
Milan Anjanappa, Malu Rafi, Saju Bhasi, Rejnish Kumar, Kainickal Cessal Thommachan, Tapesh Bhattacharya, Kunnambath Ramadas
AIM: To determine the systematic error (∑), random error (σ) and derive PTV margin at different levels of the target volumes in Nasopharyngeal Cancer (NPC). MATERIALS AND METHODS: A retrospective offline review was done for patients who underwent IMRT for NPC from June 2015 to May 2016 at our institution. Alternate day kV images were matched with digitally reconstructed radiographs to know the setup errors. All radiographs were matched at three levels - the clivus, third cervical (C3) and sixth cervical (C6) vertebra...
September 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28808428/a-comparison-of-concurrent-cisplatin-versus-cetuximab-with-radiotherapy-in-locally-advanced-head-and-neck-cancer-a-bi-institutional-analysis
#15
William A Stokes, Whitney A Sumner, Kiersten L Breggren, John T Rathbun, David Raben, Jessica D McDermott, Gregory Gan, Sana D Karam
AIM: To present our experience comparing cisplatin- and cetuximab-based radiotherapy for locally-advanced head and neck squamous cell carcinoma. BACKGROUND: The comparative effectiveness of cisplatin-based chemoradiotherapy (CRT) versus cetuximab-based bioradiotherapy (BRT) for locally-advanced head and neck squamous cell carcinoma (LAHNSCC) continues to be explored. MATERIALS AND METHODS: Outcomes of LAHNSCC patients treated with CRT (125) or BRT (34) at two institutions were compared retrospectively, with attention to overall survival (OS), cancer-specific survival (CSS), locoregional control (LRC), and distant control (DC)...
September 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28794691/biological-role-of-long-non-coding-rna-in-head-and-neck-cancers
#16
REVIEW
Tomasz Kolenda, Kacper Guglas, Marcel Ryś, Marta Bogaczyńska, Anna Teresiak, Renata Bliźniak, Izabela Łasińska, Jacek Mackiewicz, Katarzyna M Lamperska
Head and neck squamous cell carcinoma (HNSCC) are one of the worst prognosis cancers with high mortality of patients. The treatment strategy is primarily based on surgery and radiotherapy but chemotherapy is also used. Every year the knowledge concerning HNSCC biology is updated with new elements such as the recent discovered molecules - long non-coding RNAs. Long non-coding RNAs are involved in regulatory processes in the cells. It has been revealed that the expression levels of lncRNAs are disturbed in tumor cells what results in the acquisition of their specific phenotype...
September 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28794690/gender-related-prognostic-significance-of-clinical-and-biological-tumor-features-in-rectal-cancer-patients-receiving-short-course-preoperative-radiotherapy
#17
Anna Gasinska, Zbigniew Darasz, Agnieszka Adamczyk, Beata Biesaga, Joanna Niemiec, Marian Reinfuss
AIM: To study the prognostic value of clinical and biological features of rectal cancer and potential gender differences in patients' overall survival (OS), local recurrence-free survival (RFS) and metastasis-free survival (MFS) after short-course preoperative radiotherapy (SCRT) with short or long interval between RT and surgery (break). BACKGROUND: The length of the interval between RT and surgery in SCRT is debatable and gender-related differences in patients survival are not established yet...
September 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28761392/assessment-of-performance-indicators-of-a-radiotherapy-department-using-an-electronic-medical-record-system
#18
Yasir A Bahadur, Camelia Constantinescu, Ammar Y Bahadur, Ruba Y Bahadur
AIM: To retrospectively assess the performance indicators of our radiotherapy department and their temporal trends, using a commercially available electronic-medical-record (EMR) system. BACKGROUND: A recent trend in healthcare quality is to define and evaluate performance indicators of the service provided. MATERIALS AND METHODS: Patient and external-beam-radiotherapy-treatments data were retrieved using the Mosaiq EMR system from 1-January-2012 till 31-December-2015...
September 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28761391/the-accuracy-of-treatment-planning-system-dose-modelling-in-the-presence-of-brass-mesh-bolus
#19
Neil Richmond
AIM: This work assesses the dosimetric accuracy of three commercial treatment planning system (TPS) photon dose calculation algorithms in the presence of brass mesh used as a bolus. BACKGROUND: Bolus material is used in radiotherapy to provide dose build-up where superficial tissues require irradiation. They are generally water equivalent but high density materials can also be used. MATERIALS AND METHODS: Dose calculations were performed on Monaco and Masterplan TPS (Elekta AB, Sweden) using phantoms defined by the three DICOM CT image sets of water equivalent blocks (no bolus, 1 layer and 2 layers of brass mesh) exported from the CT scanner...
September 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28761390/intensity-modulated-radiation-therapy-for-small-cell-carcinoma-of-the-prostate-a-case-report
#20
Yaichiro Hashimoto, Yuka Ishii, Sawa Kono, Sachiko Izumi, Junpei Iizuka, Atsuko Hiroi, Kumiko Karasawa
Small cell carcinomas (SCC) make up only 1% of malignancies of the prostate. Reports of several case series have described outcomes of surgery and chemotherapy for SCC of the prostate, but few reports address radiotherapy. We treated a case of SCC of the prostate with intensity-modulated radiation therapy (IMRT) consisting of 70 Gy administered in 35 fractions followed by hormonal therapy using only luteinizing hormone-releasing hormone (LH-RH) agonist. The tumor volume decreased remarkably by 4 months after IMRT...
September 2017: Reports of Practical Oncology and Radiotherapy
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