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Reports of Practical Oncology and Radiotherapy

Paola Villegas-Otiniano, Jimena Vásquez-Medina, Vicente Aleixandre Benites-Zapata
The incidence of multiple primary neoplasms has been increasing over the years. Within this group, the coexistence of primary prostate cancer and primary colorectal cancer is one of the most frequent. The objective of this case report is to present the case of a 76-year-old male patient who presented the diagnosis of prostate cancer and synchronous rectal cancer. To this end, his clinical history in the oncological service of the Hospital Militar Central del Perú (tertiary hospital) has been reviewed.
September 2018: Reports of Practical Oncology and Radiotherapy
Bhattasali Onita, Thompson Lester D R, Abdalla Iman A, Chen Jergin, Iganej Shawn
AIM: To perform a comparison of Cisplatin vs. Cetuximab in p16-positive oropharyngeal squamous cell carcinoma (OPSCC) in the context of the revised HPV-based staging. BACKGROUND: Previous reports comparing these agents in head and neck cancer have included heterogenous disease and p16-status. MATERIALS AND METHODS: A retrospective review was conducted from 2006 to 2016 of patients with p16-positive OPSCC who underwent definitive radiotherapy concurrent with either triweekly Cisplatin ( n  = 251) or Cetuximab ( n  = 40)...
September 2018: Reports of Practical Oncology and Radiotherapy
Tomohei Nakao, Hiroko Fukushima, Takashi Fukushima, Ryoko Suzuki, Sho Hosaka, Yuni Yamaki, Chie Kobayashi, Atsushi Iwabuchi, Kazuo Imagawa, Aiko Sakai, Toko Shinkai, Kouji Masumoto, Shingo Sakashita, Tomohiko Masumoto, Masashi Mizumoto, Ryo Sumazaki, Hideyuki Sakurai
Aim: To assess the feasibility of transferring to the University of Tsukuba Hospital for proton beam therapy (PBT) during intensive chemotherapy in children with Ewing sarcoma family of tumors (ESFT) who had been diagnosed and started their first-line treatment at prefectural or regional centers for pediatric oncology. Background: The treatment of ESFT relies on a multidisciplinary approach using intensive neoadjuvant and adjuvant chemotherapies with surgery and radiotherapy...
September 2018: Reports of Practical Oncology and Radiotherapy
Ladan Rezaee
Aim: Design of a numerical method for creating spread-out Bragg peak (SOBP) and evaluation of the best parameter in Bortfeld Model to this aim in oxygen ion therapy. Background: In radiotherapy, oxygen ions have more biological benefits than light beams. Oxygen ions have a higher linear energy transfer (LET) and larger relative biological effectiveness (RBE) than lighter ones. Materials and methods: For the design of the spread-out Bragg peak (SOBP) for oxygen beam, we designed a numerical method using the Geant4 Monte Carlo simulation code, along with matrix computations...
September 2018: Reports of Practical Oncology and Radiotherapy
Toshiro Tsubouchi, Masashi Yagi, Iori Sumida, Keisuke Tamari, Yuji Seo, Kazuhiko Ogawa
Aim: To evaluate the influence of the beam shape created by X-rays with "flat beams" and without "flattening-filter-free [FFF] beams" a flattening filter, and the isocenter locations for FFF beams on the treatment of a large irradiated volume for tumours. Background: The increase of dose rate and the decrease of out-of-field dose can be expected for FFF beams and lead to effective and safety radiotherapy. On the other hand, the bell-shaped dose profile is thought to be a factor of negating these advantages...
September 2018: Reports of Practical Oncology and Radiotherapy
Roger Cai Xiang Soh, Guan Heng Tay, Wen Siang Lew, James Cheow Lei Lee
Aim: To identifying depth dose differences between the two versions of the algorithms using AIP CT of a 4D dataset. Background: Motion due to respiration may challenge dose prediction of dose calculation algorithms during treatment planning. Materials and methods: The two versions of depth dose calculation algorithms, namely, Anisotropic Analytical Algorithm (AAA) version 10.0 (AAAv10.0), AAA version 13.6 (AAAv13.6) and Acuros XB dose calculation (AXB) algorithm version 10...
September 2018: Reports of Practical Oncology and Radiotherapy
Celine Clerkin, Sinead Brennan, Laura M Mullaney
Aim: The aim of this research is to establish if variation exists in the dose delivered for head and neck (HN) localisation computed tomography (CT) imaging in radiation therapy (RT); to propose a national diagnostic reference levels (DRLs) for this procedure and to make a comparison between the national DRL and a DRL of a European sample. Background: CT has become an indispensable tool in radiotherapy (RT) treatment planning. It is a requirement of legislation in many countries that doses of ionising radiation for medical exposures be kept 'As Low As Reasonably Achievable'...
September 2018: Reports of Practical Oncology and Radiotherapy
Beata Sas-Korczynska, Marian Reinfuss, Jerzy W Mitus, Elzbieta Pluta, Anna Patla, Tomasz Walasek
Objectives: Radiotherapy in patients with sinonasal mucosal melanoma (SNMM) was given as alternative treatment to surgery in cases with advanced, inoperable tumors or those not eligible for surgery. We presented the outcomes for patients with SNMM treated with radiotherapy alone. Material and methods: The retrospective review of 6 consecutive SNMM (nasal cavity - 4 pts. and paranasal sinus - 2 pts.) patients (3 males and 3 females at mean age 64 years) treated between 2008 and 2016 was presented...
September 2018: Reports of Practical Oncology and Radiotherapy
Shuhei Sekii, Yoshinori Ito, Ken Harada, Mayuka Kitaguchi, Kana Takahashi, Koji Inaba, Naoya Murakami, Hiroshi Igaki, Ryohei Sasaki, Jun Itami
Aim: To investigate the intrafraction movement of the esophagus using fiducial markers. Background: Studies on intrafraction esophageal motion using the fiducial markers are scarce. Materials and methods: We retrospectively analyzed patients with clinical T1N0 esophageal cancer who had received fiducial markers at our hospital between July 2007 and December 2013. Real-Time Position Management System to track the patient's respiration was used, and each patient underwent three-dimensional computed tomography of the resting expiratory and inspiratory level...
September 2018: Reports of Practical Oncology and Radiotherapy
Miguel Ángel Souto-Del Bosque, Miguel Ángel Cervantes-Bonilla, Gerardo Del Carmen Palacios-Saucedo
Aim: To identify clinical and dosimetric factors associated with the development of hematologic toxicity (HT) for cervical cancer (CC) treated with chemotherapy and 3D conformal radiotherapy. Background: Chemoradiotherapy is the standard of care management for CC patients with IB2-IVA clinical stages (CS). This treatment carries toxicities, standing out the one that occurs at the hematologic level. Subjects and methods: CC patients with IB2-IVA CS treated with chemotherapy and 3D conformal radiotherapy (50 Gy) plus Brachyterapy (7 Gy x3 or 9 Gy x2) at our institution between March 2016 and March 2017...
September 2018: Reports of Practical Oncology and Radiotherapy
Tarcisio Passos Ribeiro de Campos, Bruno M Mendes, Bruno Trindade, Wagner L Araujo
Aim: The present study evaluated the increment of cardiac risk (CR) and absorbed dose in radiotherapy of the internal mammary chain (IMC), in particular with photon portals of 4 6 MV, and cobalt therapy (Co60); and, electron portals of 8, 12 and 16 MeV applied in the left breast, considering the adoption of a combined photon (16 Gy) and electron (30 Gy) protocols. Materials and methods: The modified ICRP-reference female model of 60 kg, 163 cm and 43 years of age, coil RCP-AF, was modelled...
September 2018: Reports of Practical Oncology and Radiotherapy
Marta Liszka, Włodzimierz Samborski
Aim: Isokinetic assessment of biomechanical parameters of the shoulder joint at the operated side versus non-operated side in patients treated surgically for breast cancer according to the type of surgery performed. Background: Despite significant progress in medicine, comprehensive cancer therapy may still cause a number of undesired structural and functional effects. The most frequent complications include long-term weakening of muscles within the shoulder and upper extremity at the operated side...
September 2018: Reports of Practical Oncology and Radiotherapy
Shahla Ebrahimi Moghadam, Shahrokh Nasseri, Seyedeh Somayeh Seyedi, Hamid Gholamhosseinian, Mehdi Momennezhad
Aim: Evaluation of application of EPID for rapid QC testing of linear accelerator. Background: Quality control of a linear accelerator device is a time and energy intensive process. In this study, attempts have been made to perform the linear accelerator quality control using electronic portal imaging device (EPID), which is mounted on most accelerators. Materials and methods: First, quality control and dosimetry parameters of the device were determined and measured based on standard protocols to ensure full calibration of the accelerator...
September 2018: Reports of Practical Oncology and Radiotherapy
Anna Boladeras, Ferran Ferrer, Valentin Navarro, Rodolfo De Blas, Oriol Cunillera, David Mateo, Cristina Gutierrez, Evelyn Martinez, Salvador Villà, Joan Pera, Montse Ferrer, Ferran Guedea
Aim: To evaluate the association between dose-volume histogram (DVH) values in organs at risk (OAR) and patient-reported HRQoL outcomes. Background: Data on the association between DVHs and health-related quality of life (HRQoL) in prostate cancer (PCa) patients are limited. Materials and methods: Five-year follow-up study of 154 patients with organ-confined (stage T1/T2) PCa treated with EBRT between January 2003 and November 2005. HRQoL was evaluated with the Expanded Prostate Cancer Index (EPIC)...
September 2018: Reports of Practical Oncology and Radiotherapy
Wui Ann Woon, Paul B Ravindran, Piyasiri Ekayanake, Subramani Vikraman, Siti Amirah, Yivonne Y F Lim, Christopher H S Vun, Jamsari Khalid
Aim: The aim of this study was to investigate the sensitivity of the trajectory log file based quality assurance to detect potential errors such as MLC positioning and gantry positioning by comparing it with EPID measurement using the most commonly used criteria of 3%/3 mm. Materials and methods: An in-house program was used to modified plans using information from log files, which can then be used to recalculate a new dose distribution. The recalculated dose volume histograms (DVH) were compared with the originals to assess differences in target and critical organ dose...
September 2018: Reports of Practical Oncology and Radiotherapy
Michał Bijok, Ewelina Gruszczynska, Adam Kowalczyk, Katarzyna Sikorska, Agnieszka Walewska, Pawel F Kukolowicz
Aim: The aim of the study was to analyze the long-term stability of electron beams generated by the Novac11™ IORT accelerator. Background: Novac11™ (NRT® ) is a mobile electron accelerator designed to irradiate small areas of tissue, up to 10 cm in diameter, with electron beams during surgical procedures. It is characterized by a great mobility guaranteed by a number of degrees of freedom enabling irradiation in the conditions of an operating theatre. Materials and methods: Over the period of January 2013 and September 2016, the measurement sessions of the output of clinically used beam qualities (6, 8 and 10 MeV) were carried out 41 times...
September 2018: Reports of Practical Oncology and Radiotherapy
Sara Imboden, Laura Knabben, Michael D Mueller, Andreas R Günthert, Kristina Lössl
An 81-year-old patient developed an exulcerous tumor in her left breast 21 years after breast cancer treatment with lumpectomy and adjuvant radiotherapy. At the time of the initial treatment 21 years ago, whole breast irradiation was performed with a prescribed dose of 48 Gy and a maximal dose of 69 Gy. In addition, the patient received a 14.7 Gy boost with multicatheter brachytherapy as partial breast irradiation. In general, fat necrosis after radiotherapy, surgery or trauma is a minor problem for patients, but can lead to diagnostic difficulties...
September 2018: Reports of Practical Oncology and Radiotherapy
Marisa R Moroney, Dina Flink, Jeanelle Sheeder, Erin A Blake, Aakriti R Carrubba, Christine M Fisher, Saketh R Guntupalli
Aim: To evaluate the associations of external beam radiation therapy (EBRT) and intracavitary brachytherapy (IB) with decreased sexual function. Background: There's inconsistent evidence on whether radiation for gynecologic cancers has an impact on sexual health. IB, an underutilized treatment modality, is thought to have less adverse effects than EBRT. Materials and methods: A cross-sectional study examining decreased sexual function following radiation for gynecologic cancers...
September 2018: Reports of Practical Oncology and Radiotherapy
Joana Pinheiro, Darlene Rodrigues, Pedro Fernandes, Alexandre Pereira, Lurdes Trigo
Introduction: The incidence of breast carcinoma (BC) has increased in the last years. Between 2 and 12% of patients diagnosed with BC will develop bilateral breast carcinoma (BBC). The treatment of these carcinomas is more aggressive than unilateral BC. Purpose: To perform a retrospective qualitative analysis of BBC patients whose treatment has included brachytherapy (BT) and to present a revised literature on this issue. Material and methods: The cases of BBC whose treatment included brachytherapy were revised...
September 2018: Reports of Practical Oncology and Radiotherapy
Gianluca Ingrosso, Alessandra Carosi, Daniela di Cristino, Elisabetta Ponti, Andrea Lancia, Marta Bottero, Alessandro Cancelli, Alessandra Murgia, Irene Turturici, Riccardo Santoni
Aim: To identify factors influencing toxicity in patients affected by localized prostate cancer treated with conformal image-guided radiotherapy. Background: Image guidance in combination with conformal techniques is the standard of care in localized prostate cancer, but factors affecting toxicity are still under investigation. Materials and methods: 294 patients were analyzed. Median age at diagnosis was 71 year. 76 Gy (38 × 2 Gy) were delivered to the target volume...
September 2018: Reports of Practical Oncology and Radiotherapy
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