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Environmental Toxicology

Ruey-Lin Chang, Srinivasan Nithiyanantham, Wei-Wen Kuo, Pei-Ying Pai, Tung-Ti Chang, Chao-Hung Lai, Ray-Jade Chen, Viswanadha Vijaya Padma, Chih-Yang Huang, Chih-Yang Huang
IGF-IIR activation regulates cardiac remodeling leading to apoptosis. Here, we identified the novel IGF-IIRα (150 KDa), a truncated IGF-IIR transcript enhances cardiac apoptosis under high-salt uptake in transgenic rat model. Echocardiographic analysis revealed decline in ejection fraction and fractional shortening percentage in IGF-IIRα (TG) rats. We found that IGF-IIRα TG rats developed severe apoptosis and fibrosis as identified through TUNEL assay and Masson's trichrome staining. Importantly, the heart functioning, apoptosis, and fibrosis were significantly affected under high-salt conditions in IGF-IIRα (TG) rats...
November 18, 2018: Environmental Toxicology
Yen-Yu Chen, Yuh-Ming Chang, Kuan-Yi Wang, Pei-Ni Chen, You-Cheng Hseu, Ke-Min Chen, Kun-Tu Yeh, Chih-Jung Chen, Li-Sung Hsu
Glioblastoma (GBM) is the most mortality brain cancer in the world. Due to high invasion and drug resistance cause the poor prognosis of GBM. Naringenin, an ingredient of citrus, exhibits many cellular functions such as antioxidant, anti-inflammation, and anticancer. Naringenin inhibits the migration of bladder and lung cancer via modulation of MMP-2 and/or MMP-9 activities, Naringenin inhibits migration and trigger apoptosis in gastric cancer cells through downregulation of AKT pathway. However, the effects of naringenin in GBM still remain to be elucidated...
November 15, 2018: Environmental Toxicology
Yi-Chen Yang, Pei-Chen Chiou, Po-Chun Chen, Po-Yi Liu, Wei-Chien Huang, Chia-Chia Chao, Chih-Hsin Tang
Lung cancer is one of the most common cancer in cancer-related deaths worldwide, which is characterized by its strong metastatic potential. The melatonin hormone secreted by the pineal grand has an antioxidant effect and protects cells against carcinogenic substances. However, the effects of melatonin in lung cancer stemness are largely unknown. We found that melatonin reduces CD133 expression by ~50% in lung cancer cell lines, while results of a sphere formation assay showed that melatonin inhibits lung cancer stemness...
November 12, 2018: Environmental Toxicology
Soo-Min Kim, Kyung-A Hwang, Ryeo-Eun Go, Jae-Hyuck Sung, Dal-Woong Choi, Kyung-Chul Choi
Cigarette smoke (CS) has harmful effects on human fertility, reproduction, and development as well as on patients suffering from metabolic diseases such as diabetes than on healthy individuals. This study was conducted to investigate the relationship between CS exposure and histological alterations of reproductive organs in female diabetic rats. We evaluated the histology of uteruses and ovaries obtained from female rats exposed to smoke from standard cigarettes for 4 weeks (28 hours a week). After CS exposure, tissue slides were made from uterine and ovarian samples and examined after hematoxylin and eosin staining...
November 12, 2018: Environmental Toxicology
Chi-Pin Lee, Yu-Nan Huang, Srinivasan Nithiyanantham, Chung-Ming Huang, Ying-Chin Ko
LncRNA transcripts have been emerged as gene regulators through transcriptional and posttranscriptional regulation. Monosodium urate monohydrate (MSU) elicits inflammatory response and a critical regulator of bone erosion in gout. The aim of this study is to clarify the pro-osteogenic role of LncRNA in MSU-induced osteoclast differentiation. We performed microarray analysis to identify stage specific expressions of LncRNA and mRNA during osteoclast differentiation in RAW264.7 cells. Among the 314 pairs of LncRNA-mRNA coexpressed patterns in the osteoclast lineage, 22 pairs revealed to have inflammatory function...
November 2, 2018: Environmental Toxicology
Ting-Ting Mo, Hua Dai, Hang Du, Rui-Yuan Zhang, Ke-Ping Chai, Yao An, Ji-Ji Chen, Jun-Ke Wang, Zi-Jin Chen, Cheng-Zhi Chen, Xue-Jun Jiang, Rong Tang, Li-Ping Wang, Qiang Tan, Ping Tang, Xin-Yu Miao, Pan Meng, Long-Bin Zhang, Shu-Qun Cheng, Bin Peng, Bai-Jie Tu, Ting-Li Han, Yin-Yin Xia, Philip N Baker
Intake of arsenic (As) via drinking water has been a serious threat to global public health. Though there are numerous reports of As neurotoxicity, its pathogenesis mechanisms remain vague especially its chronic effects on metabolic network. Hippocampus is a renowned area in relation to learning and memory, whilst recently, cerebellum is argued to be involved with process of cognition. Therefore, the study aimed to explore metabolomics alternations in these two areas after chronic As exposure, with the purpose of further illustrating details of As neurotoxicity...
October 29, 2018: Environmental Toxicology
Yung-Ming Chang, Shanmugam Tamilselvi, Hung-Jen Lin, Chin-Chuan Tsai, Yueh-Min Lin, Cecilia Hsuan Day, Vijaya Padma Viswanadha, Hsin-Nung Chang, Wei-Wen Kuo, Chih-Yang Huang
Cardiac fibrosis is a common pathophysiological process observed during chronic and stress-induced acceleration of cardiac aging. Fibrosis is a necessary process during wound healing and tissue repair. However, its deposition in organs would proceed to scarring and organ damage. Here Alpinate Oxyphyllae Fructus (AOF), a Chinese medicine extract was used to protect aging heart from collagen accumulation. About 8 weeks old, male SD rats were randomly divided into (i) Control, (ii) D-galactose induced aging (IA), (iii) IA + AOF 50 (AOF low, AL), (iv) IA + AOF 100 (AOF medium, AM), (v) IA + AOF 150 (AOF high, AH) mg/kg/day, AOF was administered orally...
October 27, 2018: Environmental Toxicology
Md Saydur Rahman, Peter Thomas
Aryl hydrocarbon receptor nuclear translocator (ARNT) is an important transcriptions factor that binds/coactivates drug-metabolizing genes in vertebrates. In this study, we report the cloning and characterization of two ARNT (ARNT-1 and ARNT-2) genes and their mRNA and protein expression in liver tissues of Atlantic croaker after co-exposure to hypoxia and 3,3',4,4'-tetrachlorobiphenyl (PCB77). The full-length croaker ARNT-1 and ARNT-2 genes encode proteins of 537 and 530 amino acids, respectively, and are highly homologous to ARNT-1 and ARNT-2 genes of other vertebrates...
October 18, 2018: Environmental Toxicology
Mabrouk Attia Abd Eldaim, Ehab Tousson, Ibrahim El Tantawy El Sayed, Walaa Mohamed Awd
This study was designed to evaluate protective effect of Saussurea lappa root aqueous extract against Ethephon (2-chloroethylphosphonic acid)-induced reproductive toxicity in rats. Control group received distilled water. Second group was given S. lappa extract at a dose 50 mg/kg bw. Third group was given Ethephon at a dose 200 mg/kg bw. Fourth, fifth, and sixth groups were given S. lappa extract before, with or after Ethephon administration, respectively. Ethephon intoxication significantly decreased serum levels of follicle stimulating hormone, luteinizing hormone, testosterone, and prolactin...
October 13, 2018: Environmental Toxicology
Zhitong Li, Wenjing Li, Jinmiao Zha, Huihui Chen, Christopher J Martyniuk, Xuefang Liang
Benzotriazole ultraviolet stabilizers (BUVSs) are widely applied ultraviolet absorbing compounds in industrial materials and personal care products. Due to their ubiquitous use and reports of bio-accumulation in aquatic organisms, these compounds are significant environmental pollutants; however, data are limited for BUVSs toxicity. In this study, juvenile zebrafish (Danio rerio) were exposed to 4 commonly used BUVSs (UV-234, UV-326, UV-329, and UV-P) at one dose of 10 or 100 μg/L for 28 days. To characterize the underlying mechanisms of different BUVSs-induced toxicities, we performed global transcriptome sequencing (RNA-Seq) in the brain (100 μg/L)...
October 13, 2018: Environmental Toxicology
Shereen M Shedid, Nadia Abdel-Magied, Helen N Saada
Oxidative stress, apoptosis, and fibrosis may play a major role in the development of radiation-induced liver damage. Betaine, a native compound widely present in beetroot, was reported to possess hepato-protective properties. The objective of this study was to investigate the influence of betaine on radiation-induced liver damage. Animals were exposed to 9 Gy applied in 3 doses of 3 Gy/wk. Betaine (400 mg/kg/d), was orally supplemented to rats after the first radiation dose, and daily during the irradiation period...
October 11, 2018: Environmental Toxicology
Paloma da Cunha de Medeiros, Ricardo Rodrigues Samelo, Ana Priscila Gomes Silva, Marcella da Silva Araujo Santiago, Fabio Andrei Duarte, Ítalo Braga de Castro, Juliana Elaine Perobelli
For the first time, juvenile toxicity of inorganic arsenic (As) was investigated in male rats, focusing on reproductive effects. As is a metalloid naturally occurring in the environment, being the inorganic forms the most toxics. Contaminated drinking water and agricultural products are the main prospectors of intoxication for general population. In the present study, Wistar male rats (21 days old) were distributed into three groups (n = 10/group): control (received vehicle-filtered drinking water), As1 (received AsNaO2 at 0...
October 6, 2018: Environmental Toxicology
Patricia López-Arellano, Keila López-Arellano, Jaquelinne Luna, Diana Flores, Javier Jiménez-Salazar, Graciela Gavia, Mario Teteltitla, Juan José Rodríguez, Alejandro Domínguez, Eduardo Casas, Ivan Bahena, Miguel Betancourt, Cristina González, Yvonne Ducolomb, Edmundo Bonilla
Perfluorooctanoic acid (PFOA) is a member of the perfluoroalkyl acid family of compounds. Due to the presence of strong carbon-fluorine bonds, it is practically nonbiodegradable and highly persistent in the environment. PFOA has been detected in the follicular fluid of women, and positively associated with reduced fecundability and infertility. However, there are no reports concerning the experimental evaluation of PFOA on oocyte toxicity in mammals. The aim of the present study was to determine if PFOA is able to induce oxidative stress in fetal ovaries and cause apoptosis in oocytes in vitro...
October 2, 2018: Environmental Toxicology
Abdul-Fattah Salah Fararjeh, Shih-Hsin Tu, Li-Ching Chen, Tzu-Chun Cheng, Yun-Ru Liu, Hang-Lung Chang, Hui-Wen Chang, Chi-Cheng Huang, Hwa-Chain Robert Wang, Wendy W Hwang-Verslues, Chih-Hsiung Wu, Yuan-Soon Ho
Breast cancer (BC) is the most common cancer affecting women worldwide and has been associated with active tobacco smoking. Low levels of nicotine (Nic) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), have been detected in cases of second-hand smoke (SHS). However, the correlation between SHS and BC risk remains controversial. In this study, we investigated whether the physiological SHS achievable dose of Nic and tobacco specific nitrosamine, NNK act together to induce breast carcinogenesis using an in vitro breast cell carcinogenesis model...
September 26, 2018: Environmental Toxicology
Jen-Ning Tsai, Chiao-Yin Sun, Yu-Ju Ding, Yun-Hsin Wang, Kang-Chieh Lo, Chi-Chung Wen, Jia-Wei Lin, Chiung-Fang Chang, Li-Sung Hsu, Hui-Min Chen, Tsorng-Harn Fong, Yau-Hung Chen
4-methylimidazole (4-MI) is an imidazole-derived organic chemical compound that can be used as a raw material in the manufacture of diverse chemicals and has been identified as an ingredient of caramel color in soybean sauce, beers, and other soft drinks. The aim of the present study was to investigate the teratogenic effects of 4-MI during zebrafish embryogenesis. Zebrafish embryos were treated with different dosages of 4-MI (0-120 mM) for different exposure durations (12-60 hours). The percentages of embryos with malformed phenotypes increased as the exposure dosages and duration time of 4-MI increased...
September 26, 2018: Environmental Toxicology
Kubra Koc, Salim Cerig, Nihal Simsek Ozek, Ferhunde Aysin, Serkan Yildirim, Ozge Cakmak, Mirkhalil Hosseinigouzdagani, Fatime Geyikoglu
Indomethacin is generally used in clinical therapeutics as a non-steroidal anti-inflammatory drug. However, its use has been limited due to the gastrointestinal and renal toxic effects of this drug. These toxic effects were associated with not only the inhibition of prostaglandin synthesis but also drug-elevated oxidative stress. To ameliorate these toxicities, natural antioxidants can be used as an alternative and/or combination therapies. Therefore, the current study was conducted to assess the renoprotective effects of oleuropein against indomethacin-induced renal damages...
September 26, 2018: Environmental Toxicology
Kai Wang, Shun-Fa Yang, Yi-Hsien Hsieh, Yuan-Yen Chang, Nuo-Yi Yu, Hui-Wen Lin, Hung-Yu Lin
Dihydromyricetin (DHM), a flavanonol compound in Ampelopsis grossedentata, possesses several biological activities. However, the molecular mechanism underlying the effects of DHM on human proliferative vitreoretinopathy (PVR) remains unclear. We explored the effects of DHM on cell migration and the metastasis-promoting proteins in human retinal pigment epithelial (RPE) cells (ARPE-19 cells). Our results revealed that DHM attenuated ARPE-19 cell invasion and migration by reducing matrix metalloproteinase-2 (MMP-2) expression...
September 26, 2018: Environmental Toxicology
Chien-Hsun Huang, Fu-Ting Wang, Wen-Hsiung Chan
Enniatins are mycotoxins of Fusarium fungi that naturally exist as mixtures of cyclic depsipeptides. Previous reports have documented hazardous effects of enniatins on cells, such as apoptosis. However, their effects on pre- and post-implantation embryonic development require further clarification. Here, we showed for the first time that enniatin B1 (ENN B1) exerts cytotoxic effects on mouse blastocyst-stage embryos and induces intracellular oxidative stress and immunotoxicity in mouse fetuses. Co-incubation of blastocysts with ENN B1 triggered significant apoptosis and led to a decrease in total cell number predominantly through loss of inner cell mass...
September 26, 2018: Environmental Toxicology
Ademola Adetokunbo Oyagbemi, Temidayo Olutayo Omobowale, Olufunke Eunice Ola-Davies, Ebunoluwa Racheal Asenuga, Temitayo Olabisi Ajibade, Olumuyiwa Abiola Adejumobi, Jeremiah Moyinoluwa Afolabi, Blessing Seun Ogunpolu, Olufunke Olubunmi Falayi, Fatimah Ayodeji, Fasilat Oluwakemi Hassan, Adebowale Bernard Saba, Adeolu Alex Adedapo, Momoh Audu Yakubu
Sodium fluoride is one of the neglected environmental contaminants. Inorganic fluorides in the environment are found in the air, water, and land. In the study, forty-male Wistar albino rats were randomly divided into four groups with 10 rats in a group. Group A was the control group which was given normal saline, Group B was exposed to 300 ppm of NaF in drinking water, while Groups C and D received NaF along Rutin (100 mg/kg and 200 mg/kg) orally daily for a week. Administration of NaF alone led to significant increases in blood pressure, and deceased serum nitric oxide...
September 26, 2018: Environmental Toxicology
Chung-Yuan Lee, Shun-Fa Yang, Po-Hui Wang, Chun-Wen Su, Hua-Fen Hsu, Hsiu-Ting Tsai, Yi-Hsuan Hsiao
The effects of Terminalia catappa leaf extracts (TCE) have been widely investigated, including its antioxidative, anti-inflammatory, and antidiabetic activity, as well as its antimetastatic effects on several types of human cancer. However, no study has examined the antimetastatic potential of TCE in cervical cancer cells. This study aimed to elucidate the potential antimetastatic properties of ethanol extracts of Terminalia catappa in 12-O-tetradecanoylphorbol-13-acetate treated human cervical cancer cells and investigate the signaling pathway of this process...
September 26, 2018: Environmental Toxicology
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