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Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research

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https://www.readbyqxmd.com/read/29304947/trading-bankruptcy-for-health-a-discrete-choice-experiment
#1
Mark G Shrime, Milton C Weinstein, James K Hammitt, Jessica L Cohen, Joshua A Salomon
BACKGROUND: Although nearly two-third of bankruptcy in the United States is medical in origin, a common assumption is that individuals facing a potentially lethal disease opt for cure at any cost. This assumption has never been tested, and knowledge of how the American population values a trade-off between cure and bankruptcy is unknown. OBJECTIVES: To determine the relative importance among the general American population of improved health versus improved financial risk protection, and to determine the impact of demographics on these preferences...
January 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29304946/do-surrogate-endpoints-better-correlate-with-overall-survival-in-studies-that-did-not-allow-for-crossover-or-reported-balanced-postprogression-treatments-an-application-in-advanced-non-small-cell-lung-cancer
#2
Mahmoud Hashim, Boris M Pfeiffer, Robert Bartsch, Maarten Postma, Bart Heeg
BACKGROUND: In previous studies, correlation between overall survival (OS) and surrogate endpoints like objective response rate (ORR) or progression-free survival (PFS) in advanced non-small cell lung cancer (NSCLC) was poor. This can be biased by crossover and postprogression treatments. OBJECTIVES: To evaluate the relationship between these two surrogate endpoints and OS in advanced NSCLC studies that did not allow for crossover or reported balanced post-progression treatments...
January 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29304945/the-burden-of-peristomal-skin-complications-on-an-ostomy-population-as-assessed-by-health-utility-and-the-physical-component-summary-of-the-sf-36v2%C3%A2
#3
Thom R Nichols, Gary W Inglese
BACKGROUND: Body-altering surgery may affect perceptions of one's self. For those with abdominal stoma surgeries, altered perceptions amplified by peristomal skin condition can increase health burdens. OBJECTIVES: To assess health utility and health-related quality of life in an adult US ostomy sample in the presence of three levels of peristomal skin condition: intact, moderately compromised, and severely compromised. METHODS: The short form 36 health survey version 2, a generic health survey incorporating the six-dimensional health state short form preference-based utility index, was chosen to assess the sample...
January 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29304944/women-s-benefits-and-harms-trade-offs-in-breast-cancer-screening-results-from-a-discrete-choice-experiment
#4
Jonathan Sicsic, Nathalie Pelletier-Fleury, Nora Moumjid
BACKGROUND: Over the past decade, the benefits and harms balance of breast cancer (BC) screening has been widely debated. OBJECTIVES: To elicit women's trade-offs between the benefits and harms of BC screening and to analyze the main determinants of these trade-offs. METHODS: A discrete-choice experiment with seven attributes depicting BC screening programs including varying levels of BC mortality, overdiagnosis, and false-positive result was used...
January 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29304943/using-a-discrete-choice-experiment-involving-cost-to-value-a-classification-system-measuring-the-quality-of-life-impact-of-self-management-for-diabetes
#5
Donna Rowen, Katherine Stevens, Alexander Labeit, Jackie Elliott, Brendan Mulhern, Jill Carlton, Hasan Basarir, Julie Ratcliffe, John Brazier
OBJECTIVES: To describe the use of a novel approach in health valuation of a discrete-choice experiment (DCE) including a cost attribute to value a recently developed classification system for measuring the quality-of-life impact (both health and treatment experience) of self-management for diabetes. METHODS: A large online survey was conducted using DCE with cost on UK respondents from the general population (n = 1497) and individuals with diabetes (n = 405). The data were modeled using a conditional logit model with robust standard errors...
January 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29304942/conducting-a-discrete-choice-experiment-study-following-recommendations-for-good-research-practices-an-application-for-eliciting-patient-preferences-for-diabetes-treatments
#6
Ellen M Janssen, A Brett Hauber, John F P Bridges
OBJECTIVES: To consolidate and illustrate good research practices in health care to the application and reporting of a study measuring patient preferences for type 2 diabetes mellitus medications, given recent methodological advances in stated-preference methods. METHODS: The International Society for Pharmacoeconomics and Outcomes Research good research practices and other recommendations were used to conduct a discrete-choice experiment. Members of a US online panel with type 2 diabetes mellitus completed a Web-enabled, self-administered survey that elicited choices between treatment pairs with six attributes at three possible levels each...
January 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29304941/eq-5d-moving-from-three-levels-to-five
#7
EDITORIAL
Andrew Lloyd
No abstract text is available yet for this article.
January 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29304940/eq-5d-5l-versus-eq-5d-3l-the-impact-on-cost-effectiveness-in-the-united-kingdom
#8
Monica Hernandez Alava, Allan Wailoo, Sabine Grimm, Stephen Pudney, Manuel Gomes, Zia Sadique, David Meads, John O'Dwyer, Garry Barton, Lisa Irvine
OBJECTIVES: To model the relationship between the three-level (3L) and the five-level (5L) EuroQol five-dimensional questionnaire and examine how differences have an impact on cost effectiveness in case studies. METHODS: We used two data sets that included the 3L and 5L versions from the same respondents. The EuroQol Group data set (n = 3551) included patients with different diseases and a healthy cohort. The National Data Bank data set included patients with rheumatoid disease (n = 5205)...
January 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29304939/standards-for-instrument-migration-when-implementing-paper-patient-reported-outcome-instruments-electronically-recommendations-from-a-qualitative-synthesis-of-cognitive-interview-and-usability-studies
#9
Willie Muehlhausen, Bill Byrom, Barbara Skerritt, Marie McCarthy, Bryan McDowell, Jeremy Sohn
OBJECTIVES: To synthesize the findings of cognitive interview and usability studies performed to assess the measurement equivalence of patient-reported outcome (PRO) instruments migrated from paper to electronic formats (ePRO), and make recommendations regarding future migration validation requirements and ePRO design best practice. METHODS: We synthesized findings from all cognitive interview and usability studies performed by a contract research organization between 2012 and 2015: 53 studies comprising 68 unique instruments and 101 instrument evaluations...
January 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29304938/payer-and-pharmaceutical-manufacturer-considerations-for-outcomes-based-agreements-in-the-united-states
#10
Joshua D Brown, Rich Sheer, Margaret Pasquale, Lavanya Sudharshan, Kirsten Axelsen, Prasun Subedi, Daniel Wiederkehr, Fred Brownfield, Sachin Kamal-Bahl
BACKGROUND: Considerable interest exists among health care payers and pharmaceutical manufacturers in designing outcomes-based agreements (OBAs) for medications for which evidence on real-world effectiveness is limited at product launch. OBJECTIVES: To build hypothetical OBA models in which both payer and manufacturer can benefit. METHODS: Models were developed for a hypothetical hypercholesterolemia OBA, in which the OBA was assumed to increase market access for a newly marketed medication...
January 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29304937/an-economic-evaluation-of-the-impact-cost-and-medicare-policy-implications-of-chronic-nonhealing-wounds
#11
Samuel R Nussbaum, Marissa J Carter, Caroline E Fife, Joan DaVanzo, Randall Haught, Marcia Nusgart, Donna Cartwright
OBJECTIVE: The aim of this study was to determine the cost of chronic wound care for Medicare beneficiaries in aggregate, by wound type and by setting. METHODS: This retrospective analysis of the Medicare 5% Limited Data Set for calendar year 2014 included beneficiaries who experienced episodes of care for one or more of the following: arterial ulcers, chronic ulcers, diabetic foot ulcers, diabetic infections, pressure ulcers, skin disorders, skin infections, surgical wounds, surgical infections, traumatic wounds, venous ulcers, or venous infections...
January 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29304936/cost-effectiveness-and-value-of-information-analysis-of-brief-interventions-to-promote-physical-activity-in-primary-care
#12
Vijay Singh Gc, Marc Suhrcke, Wendy Hardeman, Stephen Sutton, Edward C F Wilson
BACKGROUND: Brief interventions (BIs) delivered in primary care have shown potential to increase physical activity levels and may be cost-effective, at least in the short-term, when compared with usual care. Nevertheless, there is limited evidence on their longer term costs and health benefits. OBJECTIVES: To estimate the cost-effectiveness of BIs to promote physical activity in primary care and to guide future research priorities using value of information analysis...
January 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29304935/identifying-psoriasis-and-psoriatic-arthritis-patients-in-retrospective-databases-when-diagnosis-codes-are-not-available-a-validation-study-comparing-medication-prescriber-visit-based-algorithms-with-diagnosis-codes
#13
Wendy Dobson-Belaire, Jason Goodfield, Richard Borrelli, Fei Fei Liu, Zeba M Khan
BACKGROUND: Using diagnosis code-based algorithms is the primary method of identifying patient cohorts for retrospective studies; nevertheless, many databases lack reliable diagnosis code information. OBJECTIVES: To develop precise algorithms based on medication claims/prescriber visits (MCs/PVs) to identify psoriasis (PsO) patients and psoriatic patients with arthritic conditions (PsO-AC), a proxy for psoriatic arthritis, in Canadian databases lacking diagnosis codes...
January 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29304934/accounting-for-uncertainty-in-decision-analytic-models-using-rank-preserving-structural-failure-time-modeling-application-to-parametric-survival-models
#14
Iain Bennett, Noman Paracha, Keith Abrams, Joshua Ray
OBJECTIVES: Rank Preserving Structural Failure Time models are one of the most commonly used statistical methods to adjust for treatment switching in oncology clinical trials. The method is often applied in a decision analytic model without appropriately accounting for additional uncertainty when determining the allocation of health care resources. The aim of the study is to describe novel approaches to adequately account for uncertainty when using a Rank Preserving Structural Failure Time model in a decision analytic model...
January 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29304933/comparison-of-adalimumab-and-etanercept-for-the-treatment-of-moderate-to-severe-psoriasis-an-indirect-comparison-using-individual-patient-data-from-randomized-trials
#15
Kim A Papp, Min Yang, Murali Sundaram, John Jarvis, Keith A Betts, Yanjun Bao, James E Signorovitch
OBJECTIVES: To compare outcomes between adalimumab and etanercept in the treatment of moderate to severe plaque psoriasis. METHODS: Study groups included patients randomized to adalimumab or placebo (REVEAL and CHAMPION trials) and those randomized to etanercept or placebo (M10-114 and M10-315 trials). Week 12 outcomes were compared between patients receiving adalimumab and those receiving etanercept after adjusting for cross-trial differences in patient characteristics using propensity score weighting and after subtracting effects of placebo...
January 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29241905/author-response-patient-engagement
#16
LETTER
Lori Frank, Maarten de Wit, John R Kirwan, Francis Guillemin, Susan J Bartlett
No abstract text is available yet for this article.
December 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29241904/letter-to-the-editor-emerging-guidelines-for-patient-engagement-in-research
#17
LETTER
Marc Boutin, Lode Dewulf
No abstract text is available yet for this article.
December 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29241903/effect-of-dipeptidyl-peptidase-4-inhibitors-on-heart-failure-a-network-meta-analysis
#18
COMPARATIVE STUDY
Wen-Qin Guo, Lang Li, Qiang Su, Wei-Ran Dai, Zi-Liang Ye
BACKGROUND: Previous meta-analyses evaluating the effectiveness of individual dipeptidyl peptidase-4 (DPP-4) inhibitors on the risk of heart failure (HF) were limited because of the small number of trials with direct comparisons between two treatments. METHODS: A Bayesian network meta-analysis was performed to investigate the relationship between DPP-4 inhibitors and the risk of HF in patients with type-2 diabetes mellitus. The primary outcome was the occurrence of HF or hospital admission for HF...
December 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29241902/scientific-evidence-in-health-technology-assessment-reports-an-in-depth-analysis-of-european-assessments-on-high-risk-medical-devices
#19
Britta Olberg, Sabine Fuchs, Dimitra Panteli, Matthias Perleth, Reinhard Busse
BACKGROUND: The aim of this study was to examine the scientific evidence on clinical effectiveness and safety used in health technology assessments (HTAs) of high-risk medical devices (MDs) in Europe. METHODS: We applied a systematic approach to identify European institutions involved in HTA and to select reports assessing MDs considered high-risk according to the definition in the new German health care regulation §137h. Reports published between 2010 and 2015 were considered in our subsequent analysis...
December 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29241901/comparison-of-timed-automata-with-discrete-event-simulation-for-modeling-of-biomarker-based-treatment-decisions-an-illustration-for-metastatic-castration-resistant-prostate-cancer
#20
Koen Degeling, Stefano Schivo, Niven Mehra, Hendrik Koffijberg, Rom Langerak, Johann S de Bono, Maarten J IJzerman
BACKGROUND: With the advent of personalized medicine, the field of health economic modeling is being challenged and the use of patient-level dynamic modeling techniques might be required. OBJECTIVES: To illustrate the usability of two such techniques, timed automata (TA) and discrete event simulation (DES), for modeling personalized treatment decisions. METHODS: An early health technology assessment on the use of circulating tumor cells, compared with prostate-specific antigen and bone scintigraphy, to inform treatment decisions in metastatic castration-resistant prostate cancer was performed...
December 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
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