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Transplant Infectious Disease: An Official Journal of the Transplantation Society

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https://www.readbyqxmd.com/read/28520146/association-of-tenofovir-disoproxil-fumarate-with-primary-allograft-survival-in-hiv-positive-kidney-transplant-recipients
#1
Suzanne M Boyle, Gregory Malat, Meera N Harhay, Dong H Lee, Lisa Pang, Sindhura Talluri, Akshay Sharma, Tiffany E Bias, Karthik Ranganna, Alden M Doyle
BACKGROUND: Tenofovir disoproxil fumarate (TDF) is an anti-retroviral agent frequently used to treat human immunodeficiency virus (HIV). There are concerns regarding its potential to cause acute kidney injury, chronic kidney disease, and proximal tubulopathy. Although TDF can effectively suppress HIV after kidney transplantation, it is unknown whether use of TDF-based anti-retroviral therapy (ART) after kidney transplant (KT) adversely affects allograft survival. METHODS: We examined 104 HIV+ KT recipients at our center between 2001 and 2014...
May 18, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28513974/fecal-microbiota-transplantation-outcomes-in-immunocompetent-and-immunocompromised-patients-a-single-center-experience
#2
Sally Alrabaa, Ripal Jariwala, Kristen Zeitler, Jose Montero
BACKGROUND: Clostridium difficile infection (CDI) is a major infectious disease focus for which fecal microbiota transplantation (FMT) has been used with success in various patient populations. METHODS: We conducted a retrospective study of FMT in immunocompetent and immunocompromised patients to review outcomes at our center, with a focus on identifying risk factors for FMT failure in solid organ transplant (SOT) patients. FMT was conducted using universal banked frozen stool via naso-duodenal tube in patients with recurrent CDI of 3 or more episodes per our institutional protocol...
May 17, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28509330/malignancies-in-hepatitis-c-virus-positive-and-negative-kidney-transplant-recipients-a-case-controlled-study
#3
Gaëlle Dörr, Arnaud Del Bello, Florence Abravanel, Olivier Marion, Olivier Cointault, David Ribes, Laurence Lavayssière, Laure Esposito, Marie Béatrice Nogier, Anne Laure Hebral, Karine Sauné, Jacques Izopet, Nassim Kamar
BACKGROUND: Malignancies and lymphoma are common complications after kidney transplantation. However, no link has been made between the incidence of malignancies and HCV infection in this setting. This case-controlled study compared the incidence of malignancies, including lymphoma, between kidney transplant (KT) patients with or without HCV replication. PATIENTS AND METHODS: A total of 99 HCV-positive RNA-positive KT patients were matched with 198 (1:2) anti-HCV-negative patients according to age, gender, and date of transplantation, and were followed for 145...
May 16, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28508573/regional-differences-in-the-management-and-outcome-of-kidney-transplantation-in-patients-with-human-immunodeficiency-virus-infection-a-3-year-retrospective-cohort-study
#4
Marina P Cristelli, Federico Cofán, Helio Tedesco-Silva, Joan Carles Trullàs, Daniel Wagner C L Santos, Cristian Manzardo, Fernando Agüero, Asunción Moreno, Federico Oppenheimer, Fritz Diekmann, Jose O Medina-Pestana, Jose Maria Miro
BACKGROUND: In the developed world, kidney transplantation (KT) in patients with human immunodeficiency virus (HIV) infection is well established. Developing countries concentrate 90% of the people living with HIV, but their experience is underreported. Regional differences may affect outcomes. OBJECTIVES: We compared the 3-year outcomes of patients with HIV infection receiving a KT in two different countries, in terms of incomes and development. METHODS: This was an observational, retrospective, double-center study, including all HIV-infected patients >18 years old undergoing KT...
May 16, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28500778/phaeohyphomycosis-due-to-exophiala-infections-in-solid-organ-transplant-recipients-case-report-and-literature-review
#5
Kate E Oberlin, Anna J Nichols, Rossana Rosa, Adriana Dejman, Adela Mattiazzi, Giselle Guerra, George W Elgart, Lilian M Abbo
This case report and literature review underscores the cutaneous presentations of phaeohyphomycosis in the solid organ transplant population. Increased cognizance with prompt identification is critical. The therapy and clinical outcomes of phaeohyphomycosis, caused by the Exophiala genus, in the solid organ transplant population is analyzed to examine optimal care. This review highlights the inherent difficulties in providing the appropriate duration of antifungal therapy to avoid relapsing infections in immunosuppressed patients...
May 13, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28486744/epidemiology-and-outcome-of-antimicrobial-resistance-to-gram-negative-pathogens-in-bacteriuric-kidney-transplant-recipients
#6
Catherine Delmas-Frenette, Marc Dorais, Alexandre Tavares-Brum, Charles Frenette, Bing Yang, Samar Medani, Alain Duclos, Danielle Rouleau, Habib Mawad, Azemi Barama, Heloise Cardinal
BACKGROUND: In kidney transplant recipients, episodes of bacteriuria are often treated regardless of the presence of symptoms because of the lack of clear treatment guidelines suggesting otherwise. This practice may lead to the development of antimicrobial resistance. Our aim was to determine the incidence, determinants, and impact of antimicrobial resistance in kidney transplant recipients with gram-negative bacteriuria. METHOD: We conducted a single-center, retrospective cohort study in patients who received a kidney transplantation between January 2008 and June 2013...
May 9, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28475281/prolonged-viremia-in-dengue-virus-infection-in-hematopoietic-stem-cell-transplant-recipients-and-patients-with-hematological-malignancies
#7
Bárbara Brito de S Pereira, Luiz Guilherme Darrigo, Thalita Cristina de Mello Costa, Alvina Clara Felix, Belinda P Simoes, Ana Beatriz Stracieri, Paula Moreira da Silva, Marcos Mauad, Clarisse M Machado
Fever, skin rash, headache, and thrombocytopenia are considered hallmarks of dengue infection. However, these symptoms are frequently observed in infectious and non-infectious complications of hematopoietic stem cell transplant recipients and oncohematological patients. Thus, laboratory confirmation of dengue is relevant for prompt intervention and proper management of dengue in endemic and non-endemic regions. Because no prospective study of dengue has been conducted in these populations, the actual morbidity and mortality of dengue is unknown...
May 5, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28474860/flavivirus-cross-reactivity-guillain-barr%C3%A3-syndrome-and-hematopoietic-stem-cell-transplant-patient-comment-response
#8
LETTER
Sonia M Raboni, Claudia N Duarte Dos Santos
Concerning the letter by Joob and Wiwanitkit(1) about our article "Flavivirus cross-reactivity, Guillain-Barré syndrome [GBS] and hematopoietic stem cell transplant patient,"(2) we would like to emphasize that we hypothesized that GBS in the studied case could be a result of a previous flavivirus infection or caused by infection with both viruses. We have based our hypothesis on the clinical records obtained during the Zika virus (ZIKV) epidemics in Latin America. Similarly to what occurs in Southeast Asia, Brazil has annually undergone several outbreaks of dengue since its re-introduction in the Americas in 1986...
May 5, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28474756/disseminated-toxoplasmosis-after-hematopoietic-stem-cell-transplantation-showing-unusual-magnetic-resonance-images
#9
Takahiro Tateno, Masahiro Onozawa, Junichi Hashiguchi, Takashi Ishio, Sayaka Yuzawa, Satomi Matsuoka, Mizuha Kosugi-Kanaya, Kohei Okada, Souichi Shiratori, Hideki Goto, Taichi Kimura, Junichi Sugita, Masao Nakagawa, Daigo Hashimoto, Kaoru Kahata, Katsuya Fujimoto, Tomoyuki Endo, Takeshi Kondo, Shinya Tanaka, Satoshi Hashino, Takanori Teshima
We herein report a patient who had disseminated toxoplasmosis after hematopoietic stem cell transplantation showing atypical clinical presentation and neuroimaging. Parkinsonism symptoms such as muscle rigidity, bradykinesia, tremor, and postural instability were initial manifestations. Magnetic resonance imaging showed diffuse symmetrical lesions of bilateral basal ganglia lacking ringed enhancement. Post-mortem analysis revealed multiple tachyzoites of Toxoplasma gondii in the basal ganglia, mid brain, cerebellum, and cardiac muscle...
May 5, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28471073/impact-of-cytomegalovirus-dnaemia-on-overall-and-non-relapse-mortality-in-allogeneic-stem-cell-transplant-recipients
#10
Carlos Solano, Estela Giménez, José Luis Piñana, Eliseo Albert, Víctor Vinuesa, Juan Carlos Hernández-Boluda, Paula Amat, David Navarro
BACKGROUND: We conducted a retrospective single-center study to investigate the potential impact of cytomegalovirus (CMV) DNAemia on mortality in allogeneic stem cell transplant recipients (allo-SCT). METHODS: A total of 151 consecutive patients who underwent T-cell replete allo-SCT were included in the study. Patients with CMV DNAemia were treated pre-emptively with antivirals upon detection of plasma CMV DNA loads >1500 IU/mL. RESULTS: At least one episode of CMV DNAemia occurred in 109 (72...
May 4, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28470983/colonization-with-extended-spectrum-beta-lactamase-producing-enterobacteriaceae-in-solid-organ-transplantation-a-meta-analysis-and-review
#11
REVIEW
Michail Alevizakos, Athanasios Kallias, Myrto Eleni Flokas, Eleftherios Mylonakis
BACKGROUND: Extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) may cause severe infections, often preceded by ESBL-E gastrointestinal (GI) colonization. METHODS: We conducted a review of the literature, investigating the prevalence of ESBL-E GI colonization in solid organ transplant (SOT) patients and the risk for subsequent ESBL-E infection. We searched the PubMed and EMBASE databases (to April 1, 2016) looking for studies that contained data on ESBL-E colonization among transplant patients...
May 4, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28467620/adenoviral-nephritis-in-a-renal-transplant-recipient-case-report-and-literature-review
#12
Manik Veer, Rasha Abdulmassih, James Como, Zaw Min, Nitin Bhanot
Adenovirus (AdV) infections in transplant recipients may cause invasive disease. We present a case of granulomatous interstitial nephritis secondary to AdV infection in a renal transplant recipient that was initially interpreted as acute graft rejection on histopathology. Specific testing based on clinical suspicion, however, aided in making an accurate diagnosis. We present a retrospective review of all cases of AdV infection in renal transplant recipients to date, and analyze outcomes based on different treatment modalities for this disease...
May 3, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28456141/relationship-between-the-risk-factors-for-human-papillomavirus-infection-and-lower-genital-tract-precursor-lesion-and-cancer-development-in-female-transplant-recipients
#13
Caroline Alves de Oliveira Martins, Isabel Cristina Chulvis Guimarães do Val, Luis Guillermo Coca Velarde
BACKGROUND: This study aimed to analyze the relationship between the several risk factors for human papillomavirus (HPV) infection and its persistence and to assess the prevalence of the lower genital tract precursor lesions, cancer, and HPV infection in female transplant recipients, besides the most prevalent HPV types. METHODS: The methodology adopted was a cross-sectional study with a random sample of 61 patients. RESULTS: The results indicated 10 cases (16...
April 29, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28456140/comparison-of-the-rates-of-clostridium-difficile-and-bacteremia-after-delaying-fluoroquinolone-prophylaxis-from-day-0-to-day-3-post-autologous-stem-cell-transplantation
#14
Karin Koseck, Amir Steinberg, Gina Caliendo, Joanne Meyer, Sara S Kim
BACKGROUND: Prophylactic fluoroquinolones are routinely administered after stem cell transplantation (SCT) to prevent bacterial infection; however, fluoroquinolones may increase the risk of Clostridium difficile infection, particularly in immunocompromised patients. This study is designed to evaluate the effect of a delay by 3 days in fluoroquinolone prophylaxis after autologous SCT (ASCT) on the rates of C. difficile infection and bacteremia. METHODS: A single-center retrospective cohort study was performed in 118 patients who received levofloxacin prophylaxis following ASCT at our institution between November 2014 and October 2015...
April 29, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28452423/coccidioidomycosis-among-persons-undergoing-lung-transplantation-in-the-coccidioidal-endemic-region
#15
Sachin Chaudhary, Laura Meinke, Huthayfa Ateeli, Kenneth S Knox, Yuval Raz, Neil M Ampel
BACKGROUND: Coccidioidomycosis, an endemic fungal infection, is more likely to be symptomatic and severe among those receiving allogeneic transplants. While several case series have been published for various transplanted organs, none has described the incidence and outcomes in those receiving lung transplants within the coccidioidal endemic region. METHODS: Patients receiving a heart-lung, single-lung, or bilateral-lung transplantation at the University of Arizona between 1985 and 2009 were retrospectively reviewed...
April 28, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28434195/use-of-isavuconazole-in-a-patient-with-voriconazole-induced-qtc-prolongation
#16
Tracy P Trang, Alexandra M Hanretty, Charles Langelier, Katherine Yang
A 22-year-old woman with cystic fibrosis developed QTc-interval prolongation following lung transplantation in the setting of voriconazole therapy. After the discontinuation of voriconazole and initiation of isavuconazole, her QTc interval normalized. This case highlights the unique property of QTc interval shortening by isavuconazole among the triazole antifungals. This article is protected by copyright. All rights reserved.
April 23, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28429866/successful-multiple-organ-donation-after-donor-brain-death-due-to-actinomyces-israelii-meningitis
#17
Leonel Lagunes, Oscar Len, Alberto Sandiumenge, Elena Martínez-Saez, Tomás Pumarola, Marta Bodro, Antonio Macías, Jose T Silva, F Xavier Nuvials, Ramon Charco, Francesc Moreso, Teresa Pont
The increasing gap between availability of solid organs for transplantation and the demand has led to the inclusion of donors which according to current guidelines may be discarded, some of them because of the possibility for transmission of infection to their recipients. We present the first report, to the best of our knowledge, of a case of a brain-dead donor with a localized and treated Actinomyces israelii central nervous system infection who, after a thorough evaluation, led to successful transplant procedures in four recipients...
April 21, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28429575/recovery-from-talaromyces-marneffei-involving-the-kidney-in-a-renal-transplant-recipient-a-case-report-and-literature-review
#18
Juan Peng, Zhiyong Chen, Ruiming Cai, Xianen Huang, Liying Lin, Weixiang Liang, Zhongtang Xiong, Juan Chen, Hui Chen, Yuexin Yang, Shaoyan Liu, Qingping Jiang
Talaromyces marneffei is an emerging opportunistic infection among immunocompromised patients. We observe the first native case of disseminated T. marneffei involving the kidney in a renal transplant recipient in mainland China. We describe the comprehensive clinical course, and ultrasound imaging of renal transplant biopsy, pathologic images, and electron microscopy observation of the biopsy specimen, highlighting the relevance of biopsy findings and the blood culture. We also focus on the treatment and good outcome of the patient...
April 21, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28425200/high-dose-calcineurin-inhibitor-free-everolimus-as-a-maintenance-regimen-for-heart-transplantation-may-be-a-risk-factor-for%C3%A2-pneumocystis-pneumonia
#19
Yu-Ning Hu, Nan-Yao Lee, Jun-Neng Roan, Chi-Hsin Hsu, Chwan-Yao Luo
BACKGROUND: Everolimus reduces the incidence of cardiac-allograft vasculopathy (CAV) and is less renally toxic than are calcineurin inhibitors (CNIs). We evaluated the safety of CNI-free everolimus for post-heart transplant (HTx) patients. METHODS: We retrospectively reviewed the records of 36 consecutive patients who had undergone an HTx between January 2006 and December 2013 in National Cheng Kung University Hospital. All patients initially had been treated with the standard tacrolimus regimen...
April 20, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28423469/cytomegalovirus-peritonitis-after-kidney-transplantation-diagnosed-through-histopathological-examination
#20
Kiyohiko Hotta, Yuichiro Fukasawa, Yoshiki Wada, Nobuyuki Fukuzawa, Toshimori Seki, Hiroshi Harada
Among organ transplant recipients, cytomegalovirus (CMV) commonly results in various types of infection such as pneumonitis, hepatitis, and enterocolitis. However, CMV peritonitis is very rare and difficult to diagnose owing to lack of visible clinical signs. We present a case of a 35-year-old female kidney recipient who developed abdominal pain and urinary retention caused by CMV peritonitis. To our knowledge, this is the first case report of CMV peritonitis after organ transplantation to be diagnosed through histopathological examination...
April 19, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
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