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Transplant Infectious Disease: An Official Journal of the Transplantation Society

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https://www.readbyqxmd.com/read/30481402/prevalence-and-characteristics-of-hepatitis-e-virus-infection-in-kidney-transplant-recipients-a-single-center-experience-in-japan
#1
Koji Nanmoku, Yohei Owada, Yukio Oshiro, Akira Kurosawa, Taro Kubo, Takahiro Shinzato, Toshihiro Shimizu, Takaaki Kimura, Yasunaru Sakuma, Nobuo Ishikawa, Nobuhiro Ohkohchi, Hiroaki Okamoto, Takashi Yagisawa
BACKGROUND: Hepatitis E virus (HEV) infection can lead to chronic hepatitis in solid organ transplant recipients. To investigate whether HEV infection influences outcomes following kidney transplantation, we examined the prevalence of HEV infection and clinical characteristics of kidney transplant recipients in our hospital. METHODS: Our cross-sectional study included 184 kidney transplant recipients. Blood samples were obtained from all patients to detect anti-HEV immunoglobulin (Ig)A, IgM, and IgG by enzyme-linked immunosorbent assay and HEV RNA by reverse transcription-polymerase chain reaction...
November 27, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/30472777/ureaplasma-urealyticum-pyelonephritis-presenting-with-progressive-dysuria-renal-failure-and-neurologic-symptoms-in-an-immunocompromised-patient
#2
Drew J Schwartz, Alexis Elward, Gregory A Storch, David A Rosen
Ureaplasma urealyticum is a bacterial species correlated with urethritis in healthy individuals and invasive infections in immunocompromised patients. We describe a 20-year-old female with history of remote heart transplant on everolimus, mycophenolate and rituximab presenting with progressive urinary tract symptoms, renal failure and neurologic symptoms. An extensive workup ultimately identified Ureaplasma urealyticum infection and the patient successfully recovered after a course of azithromycin and doxycycline...
November 25, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/30451342/a-randomized-clinical-trial-comparing-nitrofurazone-coated-and-uncoated-urinary-catheters-in-kidney-transplant-recipients-results-from-a-pilot-study
#3
F G Menezes, L Corrêa, J O Medina-Pestana, W F Aguiar, L F A Camargo
BACKGROUND: Urinary tract infections are frequent complications early after kidney transplantation, and the use of antimicrobial coated catheters in settings other than transplantation has shown promising results for infection prevention. The purpose of this study was to compare the efficacy of Nitrofurazone-coated silicone urinary catheters with non-impregnated silicone urinary catheters in reducing bacteriuria and urinary tract infections in kidney transplant recipients. METHODS: This single-center study, randomized controlled trial at the Hospital do Rim, a tertiary referral center in kidney transplantation, located in São Paulo, Brazil...
November 19, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/30449057/high-frequency-of-multiple-hpv-types-detection-in-fanconi-anemia-patients-oral-swabs
#4
Magda Eline Guerrart Portugal, Sonia Mra Raboni, Meri Bordignon Nogueira, Luine Rosele Renaud Vidal, Amanda Helena Dingueleski, Edelaine Kluk, Carmem Bonfim, Lisandro Lima Ribeiro, Cassius Carvalho Torres-Pereira
BACKGROUND: Fanconi anemia (FA) is a rare genetic disease usually characterized by bone marrow failure and congenital malformations. The risk of development of malignancies in the oral cavity of FA patients, such as squamous cell carcinoma (SCC), increases significantly after a hematopoietic stem cells transplant (HSCT), and may also be linked with the presence of human papillomavirus (HPV) infections in the oral cavity. We investigated the prevalence and the HPV genotypes in oral mucosa of Brazilian FA patients...
November 18, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/30431230/comparison-of-risk-factors-and-outcomes-of-daptomycin-susceptible-and-nonsusceptible-vancomycin-resistant-enterococcus-faecium-infections-in-liver-transplant-recipients-a-reply-to-jorgenson-et-al
#5
LETTER
Jessica D Lewis, Andrew J Barros, Costi D Sifri
We thank Jorgenson et al. for commenting on our paper. In their letter, the authors provide an analysis of daptomycin non-susceptible vancomycin-resistant Enterococcus (DNS-VRE) infections in liver transplant recipients (LTRs) at their transplant center, comparing 9 episodes of DNS-VRE infection with 61 episodes of daptomycin-susceptible vancomycin-resistant Enterococcus (DS-VRE) infection. This article is protected by copyright. All rights reserved.
November 15, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/30431215/donor-derived-hsv-hepatitis-in-a-kidney-transplant-recipient-leading-to-liver-fibrosis-and-portal-hypertension
#6
Brian I Shaw, Aditya J Nanavati, Vanessa Taylor, Rachel A Miller, Matt Kappus, Andrew S Barbas
The unexpected transmission of donor-derived infection through organ transplantation is a rare event with current donor screening practices. In this case report we describe a probable donor-derived transmission of Herpes Simplex Virus (HSV)-2 via deceased donor kidney transplantation resulting in HSV hepatitis in the recipient. This manifested as acute liver failure which resolved with appropriate anti-viral therapy. Following recovery from the acute liver insult, the patient developed cirrhotic liver morphology and portal hypertension, an unusual departure from the typical course...
November 15, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/30431214/nfkb1-promoter-polymorphism-a-new-predictive-marker-of-cmv-infection-after-kidney-transplantation
#7
Francesca Leone, Paolo Gigliotti, Antonella La Russa, Danilo Lofaro, Anna Perri, Donatella Vizza, Simona Lupinacci, Giuseppina Toteda, Martina Bonofiglio, Pierangela Presta, Roberta Talarico, Benedetta Aquino, Renzo Bonofiglio
INTRODUCTION: CMV infection represents a common cause of morbidity and mortality in kidney transplant recipients (KTR). The NF-kB signaling pathway is highly involved in the pathogenesis of CMV infection. The -94ins/delATTG functional polymorphism in the promoter of NFKB1 has been associated with low intra-cellular levels of the protein and high incidence of inflammatory and autoimmune disease. In this study, we evaluated the association of this NFKB1 polymorphism with the risk of CMV infection...
November 15, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/30414316/human-herpesvirus-6-encephalitis-in-patients-administered-mycophenolate-mofetil-as-prophylaxis-for-graft-versus-host-disease-after-allogeneic-hematopoietic-stem-cell-transplantation
#8
Yumiko Inui, Kimikazu Yakushijin, Atsuo Okamura, Yasuhiro Tanaka, Isaku Shinzato, Tetsuhiko Nomura, Hiroya Ichikawa, Yu Mizutani, Akihito Kitao, Keiji Kurata, Seiji Kakiuchi, Yoshiharu Miyata, Yukinari Sanada, Koichi Kitagawa, Kiyoaki Uryu, Shinichiro Kawamoto, Katsuya Yamamoto, Hiroshi Matsuoka, Tohru Murayama, Mitsuhiro Ito, Hironobu Minami
BACKGROUND: Human herpesvirus 6 (HHV-6) encephalitis is a known life-threatening complication following allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, few studies have focused on the occurrence of HHV-6 encephalitis in patients receiving mycophenolate mofetil (MMF) combined with a calcineurin inhibitor as prophylaxis for graft-versus-host disease (GVHD). This study aimed to investigate the impact of MMF administered for GVHD prophylaxis in the occurrence of HHV-6 encephalitis after allo-HSCT and the characteristics of this condition...
November 10, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/30414295/an-unusual-case-of-nocardia-cyriacigeorgica-presenting-with-spinal-abscesses-in-a-renal-transplant-recipient-and-a-review-of-the-literature
#9
Jeffrey A Freiberg, Kapil K Saharia, Megan K Morales
Nocardia species represent a well-recognized yet uncommon cause of opportunistic infections in humans. It most frequently presents as a pulmonary infection with or without central nervous system (CNS) involvement. It is a very rare cause of spinal abscesses, with only 26 cases reported in the literature. Here we report a 49-year-old man with a history of renal transplantation who presented with low back pain and was diagnosed with epidural and paraspinal abscesses due to Nocardia cyriacigeorgica that was successfully treated with antimicrobial therapy alone...
November 10, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/30414224/emphysematous-pyelonephritis-in-renal-allograft-related-to-antibody-mediated-rejection-a-case-report-and-literature-review
#10
Kazuhiro Takahashi, Lauren E Malinzak, Mohamed Safwan, Dean Y Kim, Anita K Patel, Jason E Denny
Emphysematous pyelonephritis (EPN) is a rare condition which can rapidly progress to sepsis and multiple organ failure with high mortality. We experienced a rare case of EPN in a renal allograft related to antibody-mediated rejection (AMR). The patient received a deceased donor kidney transplant due to end-stage renal disease secondary to diabetes mellitus. Cross-match test was negative but she had remote history of anti-HLA-A2 antibody corresponding with the donor HLA. Surgery concluded without any major events...
November 9, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/30407701/reassessment-of-clinical-implication-of-pretransplant-surgical-procedures-for-pulmonary-invasive-fungal-lesions
#11
Naoki Shingai, Satoshi Kaito, Yuta Yamada, Tatsuya Konishi, Akihito Nagata, Shuhei Kurosawa, Kyoko Watakabe-Inamoto, Aiko Igarashi, Yuho Najima, Hideharu Muto, Takeshi Kobayashi, Noriko Doki, Kazuhiko Kakihana, Hisashi Sakamaki, Kazuteru Ohashi
Dealing with the recent series of allogeneic hematopoietic stem cell transplantation (allo-SCT) performed this decade, we reassessed the clinical impact of pretransplant surgical procedures (SP) for pulmonary lesions of invasive fungal disease (IFD) on subsequent transplant outcome. We focused on the clinical outcomes of seven patients with pulmonary IFD who underwent segmentectomy (n = 4), lobectomy (n = 2) or abscess incision with drainage only (n = 1), and compared results to those of 21 patients carrying pulmonary IFD who never underwent invasive SP before allo-SCT...
November 8, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/30403433/guillain-barr%C3%A3-syndrome-post-renal-transplant-a-systematic-review
#12
Cecilia Ostman, Bobby Chacko
BACKGROUND: Guillain-Barré syndrome (GBS) is a common ascending polyneuropathy in adults. It is often associated with preceding viral or diarrhoeal illness with cytomegalovirus (CMV), Epstein-Barr virus (EBV), or Campylobacter jejuni. Solid organ transplant recipients are more susceptible to opportunistic infections with CMV than the general population as a result of immunosuppressive therapies to prevent graft rejection. However, reports of GBS are rare in this population. OBJECTIVE: To systematically review cases of GBS in renal transplant patients to evaluate causative pathogens or triggers, management and associated morbidity and mortality...
November 7, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/30403322/successful-treatment-of-ureaplasma-induced-hyperammonemia-syndrome-post-lung-transplant
#13
Kristine M Matson, David A Sonetti
Hyperammonemia, in the absence of significant liver dysfunction, is an uncommon but often fatal occurrence following orthotopic lung transplant. Prior reports have provided evidence to support Ureaplasma species as an etiology for this syndrome. This case report describes an individual post-lung transplant, treated emperically with doxycycline along with other measures to lower ammonia levels, at the time hyperammonemia with encephalopathy was recognized. The patient clinically improved. Ureaplasma species were subsequently identified using 16S ribosomal RNA gene PCR/sequencing of pleural fluid, and by culture of bronchoalveolar (BAL) fluid...
November 7, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/30375710/evaluation-of-histological-dynamics-kidney-function-and-diabetes-in-liver-transplant-patients-after-antiviral-treatment-with-direct-acting-antivirals
#14
Eva M Teegen, Michael Dürr, Max M Maurer, Franziska Eurich, Antonia Vollbort, Brigitta Globke, Marcus Bahra, Hendrik Blaeker, Johann Pratschke, Dennis Eurich
BACKGROUND: Direct acting antivirals allow efficient and safe treatment of hepatitis C (HCV) before and after liver transplantation. However, the impact of sofosbuvir on the graft, diabetes and on kidney function is not answered yet. Primary endpoint of this analysis was the evaluation of kidney function after AVT. Secondary endpoints were the assessment of extrahepatic manifestation of HCV-infection by diabetes mellitus and the histopathological changes in terms of inflammation, content of fat and fibrosis stage...
October 30, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/30371970/esophageal-mycobacterium-avium-intracellulare-infection-in-a-bone-marrow-transplant-patient-case-report-and-literature-review
#15
Rong Hou, Ravi Nayak, Steven M Pincus, Jinping Lai, Louay M Omran, Samer Al-Kaade, Getahun Abate
Mycobacterium avium-intracellulare complex (MAC) is the most common cause of nontuberculous mycobacterial (NTM) disease in humans. We report a case of esophageal MAC-disease in a patient who had allogeneic bone marrow transplant for acute lymphoblastic leukemia. Although pulmonary MAC in immunocompromised host is not uncommon, there are only a few cases of NTM-associated esophageal mass reported. Our report and literature review highlight the importance of considering MAC in the differential diagnosis of dysphagia or odynophagia...
October 29, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/30369006/antibiotic-lock-therapy-for-salvage-of-tunneled-central-venous-catheters-with-catheter-colonization-and-catheter-related-bloodstream-infection
#16
Saurabh Zanwar, Punit Jain, Anant Gokarn, Santhosh Kumar Devadas, Sachin Punatar, Sachin Khurana, Avinash Bonda, Ritesh Pruthy, Vivek Bhat, Sajid Qureshi, Navin Khattry
Central Venous Catheters (CVCs) represent a significant source of infection in patients undergoing hematopoietic stem cell transplantation and can add to the cost of care, morbidity, and mortality. Organisms forming biofilms on the inner surface of catheters require a much higher local antibiotic concentration to clear the pathogen growth. Antibiotic lock therapy (ALT) represents one such strategy to achieve such high intraluminal concentrations of antibiotics and can facilitate catheter salvage. Patients with catheter colonization (CC) or hemodynamically stable catheter-related bloodstream infection (CRBSI) received ALT per institutional policy...
October 27, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/30369001/treatment-of-chronic-hepatitis-c-viral-infection-with-sofosbuvir-and-daclatasvir-in-kidney-transplant-recipients
#17
Hongfeng Huang, Huanna Tang, Hao Deng, Jia Shen, Qin Zhou, Wenqing Xie, Jianyong Wu, Jianghua Chen
OBJECTIVES: To assess the efficacy and the risk of sofosbuvir-daclatasvir treatment among kidney transplant recipients (KTRs) with chronic hepatitis C virus (HCV) infection. METHODS: A real-life retrospective cohort analysis was performed on KTRs treated with sofosbuvir-daclatasvir at our center between January 2016 and March 2018. We collected data from 19 KTRs (13 males; age 48.3 ± 9.6 years; HCV genotype I, n = 16; chronic active hepatitis B coinfection, n = 8)...
October 27, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/30358045/comparison-of-universal-prophylaxis-and-preemptive-approach-for-cytomegalovirus-associated-outcome-measures-in-renal-transplant-patients-a-meta-analysis-of-available-data
#18
Hulya Caskurlu, Fatma Y Karadag, Ferhat Arslan, Yasemin Cag, Haluk Vahaboglu
Cytomegalovirus (CMV) is a ubiquitous latent human virus that often causes complications in renal transplantation recipients. Universal prophylaxis and preemptive therapy are alternative strategies to prevent CMV associated complications. This meta-analysis aimed to assess available data comparing the effectiveness of prophylaxis and preemptive therapy for preventing adverse outcomes. We searched the PubMed, Ovid, Web of Science, Cochrane Library, and Open Grey databases using a combination of keywords. Random effects models along with the Paule-Mandel estimator were used to synthesize pooled effect estimates...
October 24, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/30358023/impact-of-donor-and-recipient-cytomegalovirus-serology-on-long-term-survival-of-heart-transplant-recipients
#19
C Mabilangan, J K Preiksaitis, C Cervera
BACKGROUND: Some studies have shown that pre-transplant cytomegalovirus (CMV) serostatus is associated with heart transplant patient survival while others have not. We analyzed the relationship between pre-transplant donor/recipient CMV serostatus and long-term mortality in a retrospective cohort of heart transplant recipients at our center. METHODS: Adult (Age >17y) heart recipients transplanted between July 1985-December 2015 were analyzed. Variables included age, sex, pre-transplant donor (D)/recipient (R) serostatus [D-/R-, D-/R+, D+/R+, D+/R-], CMV infection within 2 years of transplant and transplant eras divided by changes in CMV prevention strategies: Era 1 (Pre-ganciclovir, July 1985-April 1998), Era 2 (Oral ganciclovir, May 1998-December 2004), Era 3 (Valganciclovir, January 2005-December 2015)...
October 24, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/30346638/primary-infection-with-human-herpes-virus-type-6-post-pediatric-liver-transplantation-a-pathogen-to-remember
#20
Adi Pappo-Toledano, Sara Dovrat, Zvia Soufiev, Yael Mozer-Glassberg, Irit Krause, Eran Rom, Raanan Shamir, Efraim Bilavsky
BACKGROUND: In recent years, liver transplantation (LT) has become a well-accepted therapeutic modality for children with end-stage liver disease, with transplantation surgery being performed at a younger age. Human herpes virus 6 (HHV-6) infection occurs in most children within the first 2 years of life, therefore, data on primary HHV-6 infection in pediatric liver transplant recipients is scarce. OBJECTIVE: To describe the course of primary HHV-6 infection after pediatric LT...
October 22, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
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