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Transplant Infectious Disease: An Official Journal of the Transplantation Society

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https://www.readbyqxmd.com/read/30102820/kidney-transplant-recipients-with-polycystic-kidney-disease-have-a-lower-risk-of-post-transplant-bk-infection-than-those-with-end-stage-renal-disease-due-to-other-causes
#1
Callie Plafkin, Tripti Singh, Brad C Astor, Sandesh Parajuli, Gauri Bhutani, Nasia Safdar, Sarah E Panzer
BACKGROUND: Polyomavirus-associated nephropathy is associated with high risk of kidney allograft loss. Whether the cause of native end-stage renal disease influences the risk of BK infection is unclear. METHODS: A retrospective, single-center study of 2,741 adult kidney transplant recipients between 1994 to 2014 was performed. Recipients had end-stage renal disease due to polycystic kidney disease (PKD, n=549), diabetes mellitus (DM, n=947), hypertension (HTN, n=442), or glomerulonephritis (GN, n=803)...
August 13, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/30080955/safety-and-effectiveness-of-direct-acting-antivirals-for-treatment-of-hepatitis-c-virus-in-patients-with-solid-organ-transplantation
#2
Marlina Mansour, Lucas Hill, Janice Kerr
BACKGROUND: The direct acting antivirals (DAAs) for treatment of hepatitis C virus (HCV) infection have sustained virologic response (SVR) rates of greater than 90% in most patients. However, data evaluating DAA use in transplant patients are limited. The goal of this study was to evaluate the effectiveness and safety of HCV treatment in this high-risk population. METHODOLOGY: This single-center retrospective study included liver, kidney, lung and/or heart transplant patients who were treated for HCV infection with DAAs...
August 6, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/30074295/determination-of-viremia-cut-off-for-risk-to-develop-bkpyv-associated-nephropathy-among-kidney-transplant-recipients
#3
Camila Silva Bicalho, Renato Dos Reis Oliveira, Daísa Ribeiro David, Maria Cristina Domingues Silva Fink, Fabiana Agena, Maria Cristina Castro, Cláudio Panutti, Elias David-Neto, Ligia Camera Pierrotti
BACKGROUND: BK polyomavirus (BKPyV)-associated nephropathy (BKPyVAN) is a consequence of BKPyV replication in the urinary tract in kidney transplant recipients (KTR). OBJECTIVES: The objectives were to determine the prevalence of BKPyV replication and BKPyVAN, risk factors associated to sustained viremia and BKPyVAN, and viremia cut-off that best predict the occurrence of sustained viremia and nephropathy in KTR of a single University Hospital Kidney Transplant Center...
August 3, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/30055044/actinomycosis-an-infrequent-disease-in-renal-transplant-recipients
#4
Celia Rousseau, Lionel Piroth, Vincent Pernin, Elisabeth Cassuto, Isabelle Etienne, Ahmed Jeribi, Nassim Kamar, Claire Pouteil-Noble, Christiane Mousson
Actinomycosis is a rare and heterogeneous infection involving Gram-positive anaerobic bacteria, which are commensals in the oral cavity and digestive tract. Only four cases of actinomycosis in renal transplant recipients have been reported to date. We performed a retrospective study in French renal transplantation centers to collect data about actinomycosis, patients and transplantation. Seven cases were reported between 2000 and 2017; mean age was 55.7 years, and prevalence of actinomycosis was 0.02%. Median time between transplantation and infection was 104 months (4 to 204 months)...
July 28, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/30055041/donor-derived-mycobacterium-tuberculosis-infection-after-solid-organ-transplantation-a-comprehensive-review
#5
REVIEW
Cybele Lara R Abad, Raymund R Razonable
BACKGROUND: Mycobacterium tuberculosis may be transmitted via the allograft to cause a morbid and potentially fatal infection after solid organ transplantation (SOT). We reviewed all reported cases of donor-derived tuberculosis (DDTB) to provide an update on its epidemiology, clinical course, and outcome after SOT. METHODS: MEDLINE, OVID, and EMBASE were reviewed from its inception until December 31, 2016 using key words donor-derived infection, tuberculosis and solid organ transplant or transplantation...
July 28, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/30030892/dapsone-safety-in-hematology-patients-pathways-to-optimizing-pneumocystis-jirovecii-pneumonia-prophylaxis-in-hematology-malignancy-and-transplant-recipients
#6
Karen F Urbancic, Daisy Pisasale, Joel Wight, Jason A Trubiano
Dapsone may be used for Pneumocystis jirovecii pneumonia (PJP) prophylaxis in hematology patients receiving immunosuppressive therapy or after hematopoietic stem cell transplant (HSCT) in the setting of trimethoprim-sulfamethoxazole (TMP-SMX) adverse drug reaction (ADR) history. Dapsone-induced hematological toxicities such as oxidative hemolysis may limit use in these patients and modern assessments of dapsone allergy cross-reactivity in non-HIV patients with a sulfonamide allergy are largely absent. The aim of this single-centre, retrospective study was to describe dapsone usage in hematology patients requiring PJP prophylaxis, including HSCT recipients, over a 12-month period in terms of indications, incidence of dapsone-attributed oxidative hemolysis, and immune cross-reactivity in those previously labeled with a sulfonamide allergy, as well as describing potential opportunities for first-line TMP-SMX PJP prophylaxis reintroduction...
July 21, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/30014622/successful-treatment-of-primary-donor-derived-human-herpesvirus-8-infection-and-hepatic-kaposi-sarcoma-in-an-adult-liver-transplant-recipient
#7
Whitney Fu, Jonathan Merola, Maricar Malinis, Jill Lacy, Andrea Barbieri, Annmarie H Liapakis, David C Mulligan, Peter S Yoo
Kaposi sarcoma (KS) may rarely occur in transplant recipients through primary human herpesvirus-8 (HHV-8) infection from a seropositive donor. This report describes a patient who developed hepatic KS after receiving a split liver transplant from an HHV-8-positive donor. The recipient was treated with liposomal doxorubicin after reduction of immunosuppression led to acute cellular rejection. This treatment achieved regression of KS while preserving allograft function, demonstrating a successful therapeutic strategy for this malignancy...
July 17, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/30011107/fecal-microbiota-transplantation-for-recurrent-clostridium-difficile-infection-in-patients-with-solid-organ-transplants-an-institutional-experience-and-review-of-the-literature
#8
Steven C Lin, Carolyn D Alonso, Alan C Moss
Clostridium difficile, an anaerobic gram-positive, spore-forming bacillus, has become the most common cause of nosocomial infectious diarrhea, and is associated with increased mortality in all populations. Patients who have received solid organ transplants (SOT) are at increased risk of Clostridium difficile infection (CDI) and CDI recurrence (rCDI). This may be related to chronic immunosuppression, frequent antibiotic exposure, and increased or prolonged hospitalizations. Increased morbidity and mortality from CDI is well-described in SOT patients...
July 16, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29989279/letermovir-successfully-used-for-secondary-prophylaxis-in-a-heart-transplant-recipient-with-ganciclovir-resistant-cytomegalovirus-syndrome-ul97-mutation
#9
Pearlie P Chong, Dagny Teiber, Bonnie C Prokesch, Reuben J Arasaratnam, Matthias Peltz, Mark H Drazner, Sonia Garg
Letermovir was approved by the Food and Drug Administration (FDA) in November 2017 for use in adult cytomegalovirus (CMV)-seropositive allogeneic stem cell transplant (SCT) recipients for primary prophylaxis of CMV infection and disease. We report off-label use of letermovir for secondary prophylaxis of genotype-confirmed ganciclovir-resistant cytomegalovirus (CMV) syndrome (UL 97 mutation [C603W]) in a heart transplant recipient initially treated with intravenous cidofovir followed by foscarnet, both discontinued due to unacceptable toxicities...
July 10, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29981174/impact-of-donor-and-recipient-cytomegalovirus-serology-on-long-term-survival-of-lung-transplant-recipients
#10
Curtis Mabilangan, Jutta Preiksaitis, Carlos Cervera
BACKGROUND: Pre-transplant cytomegalovirus (CMV) serostatus has been associated with lung transplant patient survival. We retrospectively analyzed the relationship between pre-transplant donor/recipient CMV serostatus and long-term mortality in a cohort of lung transplant recipients at our center. METHOD: Adult (Age >17 years) lung recipients transplanted between July 1985-December 2015 were analyzed. Variables included age, sex, pre-transplant donor (D)/recipient (R) serostatus [D-/R-, D-/R+, D+/R+, D+/R-], CMV infection within 2 years of transplant and transplant eras divided by changes in CMV prevention strategies: Era 1 (pre-ganciclovir, July 1985-April 1998), Era 2 (oral ganciclovir, May 1998-December 2004), Era 3 (valganciclovir, January 2005-December 2015)...
July 7, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29975816/the-clinical-and-economic-impact-of-cytomegalovirus-infection-in-recipients-of-hematopoietic-stem-cell-transplantation
#11
Brandon J Webb, Rachel Harrington, Jason Schwartz, Jennifer Kammerer, James Spalding, Edward Lee, Bart Dodds, Stephanie Kaufusi, Bruce E Goodman, Sean D Firth, Greta Martin, Jeffrey Sorensen, Daanish Hoda
BACKGROUND: CMV infection (CMV-I) remains an important complication of hematopoietic stem cell transplantation (HSCT). METHODS: This was a retrospective, single-center cohort study in HSCT recipients. Primary outcomes were adjusted cost and all-cause mortality. Secondary analyses investigated CMV risk factors and the effect of serostatus. RESULTS: Overall, 690 transplant episodes were included (allogeneic [n = 310]; autologous [n = 380])...
July 5, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29975810/unrecognized-pre-transplant-disseminated-coxiella-burnetti-infection-diagnosed-in-a-post-transplant-heart-kidney-recipient
#12
Deeksha Jandhyala, Saira Farid, Maryam Mahmood, Paul Deziel, Omar Abu Saleh, Didier Raoult, Elena Beam
To the best of our knowledge, we report the first case of pre-transplant unrecognized disseminated Coxiella burnetii infection, unmasked in the post-transplant period leading to both heart and kidney allograft dysfunction. A 59 year old man with a history of simultaneous heart-kidney transplantation due to end stage heart failure from severe aortic regurgitation (AR) and cryoglobulinemic immune complex mediated concentric necrotizing glomerulonephritis (GN), presents with a history of intermittent fevers and fatigue...
July 5, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29975806/tenofovir-alafenamide-associated-fatal-lactic-acidosis-in-an-autologous-hematopoietic-stem-cell-transplant-recipient
#13
Sammar R Alsunaid, Humayun Ashraf, Ayman O Soubani
Fatal lactic acidosis has been reported while on the treatment with Nucleoside/nucleotide analogues (NA) for the treatment of hepatitis B, C and HIV. No cases of such a complication have been reported in hematopoietic stem cell transplant (HSCT) recipients. We present a 65-year male who underwent autologous HSCT for the treatment of multiple myeloma. Prior to transplant he was started on single agent tenofovir alafenamide (TAF) for treatment of resolved hepatitis B infection. He presented few weeks later with severe lactic acidosis...
July 5, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29975443/safety-and-efficacy-of-chronic-suppressive-azole-therapy-for-endemic-fungal-infections-in-solid-organ-transplant-recipients
#14
Sonya A Trinh, Ignacio A Echenique, Sudhir Penugonda, Michael P Angarone
BACKGROUND: Although the research is limited, treatment guidelines recommend lifelong suppressive azole therapy for disseminated endemic fungal infection (EFI) after solid organ transplantation (SOT). Suppressive azole therapy may prevent EFI recurrence at the risk of hepatotoxicity and drug interactions. We present real-world safety and effectiveness data of chronic suppressive azole therapy for EFI in SOT recipients over a 10-year period at a single comprehensive transplant center. METHODS: A retrospective analysis was conducted of SOT recipients diagnosed with EFI from January 1, 2005, to May 1, 2015...
July 5, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29968947/recurrent-membranous-nephropathy-and-acute-cellular-rejection-in-a-patient-treated-with-direct-anti-hcv-therapy-ledipasvir-sofosbuvir
#15
Naoka Murakami, Yanli Ding, David J Cohen, Anil K Chandraker, Helmut G Rennke
Direct-acting antiviral agents (DAAs) are very effective therapy for chronic hepatitis C infection, and have revolutionized the treatment of hepatitis C in kidney allograft recipients. Although well tolerated in general, rare renal complications have been reported. We describe a case of recurrent membranous nephropathy and acute cellular rejection in a kidney allograft recipient after DAA (ledipasvir/sofosbuvir) therapy, whose allograft function had been stable for more than 30 years. The patient was presented with nephrotic range proteinuria with stable creatinine...
July 3, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29959880/risk-acceptance-of-human-t-lymphotropic-virus-infection-in-solid-organ-transplantation-a-survey-of-atlantic-canadian-ambulatory-patients
#16
Glenn Patriquin, Jill E Hatchette, Todd F Hatchette
BACKGROUND: Human T-lymphotropic virus (HTLV) has an estimated prevalence of 12 per 100 000 in the general Canadian population (with higher rates in distinct groups) and is most commonly transmitted by breast feeding, sexual intercourse, sharing injection tools, and blood transfusions. A minority of those infected will develop severe disease. Health Canada mandates that people who are positive for HTLV are not suitable to be solid organ donors. Given the apparent low-disease burden of HTLV in Canada, we explored HTLV risk tolerance among patients, in the context of organ transplantations...
June 30, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29896920/decrease-in-eosinophilia-as-a-marker-of-response-to-therapy-in-solid-organ-transplant-candidates-with-strongyloides-infection-a-single-center-experience
#17
LETTER
Jacques Simkins, Shweta Anjan, Jose Fernando Camargo
No abstract text is available yet for this article.
June 13, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29896858/prediction-of-bk-viremia-by-urine-viral-load-in-renal-transplant-patients-an-analysis-of-bk-viral-load-results-in-paired-urine-and-plasma-samples
#18
Kathleen Madden, Charles Janitell, Daniel Sower, Shangxin Yang
BK virus (BKPyV)-associated nephropathy (BKPyVAN) may affect up to 10% of renal transplant recipients, causing graft failure in the absence of intervention. The dilemma in monitoring BKPyVAN in renal transplant patients has been that only testing urine BK viral load represents higher sensitivity (earlier detection) but lower specificity, while testing plasma BK viral load represents lower sensitivity (later detection) but higher specificity. However, blindly testing both urine and plasma inevitably contributes to unnecessary medical cost...
June 13, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29896857/diagnosis-of-invasive-mold-diseases-in-patients-with-hematological-malignancies-using-aspergillus-mucorales-and-panfungal-pcr-in-bal
#19
Elisabeth Wehrle-Wieland, Kristina Affolter, Daniel Goldenberger, Sarah Tschudin Sutter, Joerg Halter, Jakob Passweg, Michael Tamm, Nina Khanna, Daiana Stolz
BACKGROUND: Accurate diagnosis of invasive mold diseases (IMD) remains challenging. Here, the performance of panfungal PCR, Aspergillus and MucoralesPCR in bronchoalveolar lavage (BAL) was evaluated. METHODS: We conducted a single-center study including 167 hematologic patients at risk for IMD with BAL performed 2011-2014. Diagnostic performance of single tests (Aspergillus-, Mucorales-, and panfungal PCR, galactomannan (GM)≥0.5 and ≥1, culture/cytology) or in combination was calculated for predicting IMD comparing proven/probable or proven/probable/possible IMD vs no IMD, respectively...
June 13, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29896814/mycobacterium-abscessus-left-ventricle-assist-device-driveline-infections-an-emerging-pathogen
#20
Jonatan David Nunez Breton, Gabriel Hernandez, Jacques Simkins, Sandra Viviana Chaparro
The use of left ventricular assist device is associated with improvement in survival in patients with refractory heart failure. However, driveline infection limits the success of its use as it is associated with significant mortality. We describe the first 2 cases of Mycobacterium abscessus driveline infection. Both patients had persistent infection despite of aggressive antibiotic treatment and local debridement, and only improved after removal of their left ventricular assist devices.
June 13, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
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