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Drugs in R&D

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https://www.readbyqxmd.com/read/27905016/author-s-reply-to-srinivas-a-single-dose-escalation-study-to-evaluate-the-safety-and-pharmacokinetics-of-orally-administered-des-aspartate-angiotensin-i-in-healthy-subjects
#1
LETTER
https://www.readbyqxmd.com/read/27905015/comment-on-a-single-dose-escalation-study-to-evaluate-the-safety-and-pharmacokinetics-of-orally-administered-des-aspartate-angiotensin-i-in-healthy-subjects
#2
LETTER
https://www.readbyqxmd.com/read/27888449/salvia-sage-a-review-of-its-potential-cognitive-enhancing-and-protective-effects
#3
REVIEW
Adrian L Lopresti
Genus Salvia, commonly known as sage, is the largest genus in the Lamiaceae family. It comprises many species traditionally used as brain-enhancing tonics. In vitro and animal studies have confirmed that several Salvia species contain a large array of active compounds that may enhance cognitive activity and protect against neurodegenerative disease. In this review, the active constituents in plants belonging to the genus Salvia are summarised, and their influence on pharmacodynamics pertinent to cognitive activity are detailed...
November 25, 2016: Drugs in R&D
https://www.readbyqxmd.com/read/27853957/a-guide-to-medications-inducing-salivary-gland-dysfunction-xerostomia-and-subjective-sialorrhea-a-systematic-review-sponsored-by-the-world-workshop-on-oral-medicine-vi
#4
REVIEW
Andy Wolff, Revan Kumar Joshi, Jörgen Ekström, Doron Aframian, Anne Marie Lynge Pedersen, Gordon Proctor, Nagamani Narayana, Alessandro Villa, Ying Wai Sia, Ardita Aliko, Richard McGowan, Alexander Ross Kerr, Siri Beier Jensen, Arjan Vissink, Colin Dawes
BACKGROUND: Medication-induced salivary gland dysfunction (MISGD), xerostomia (sensation of oral dryness), and subjective sialorrhea cause significant morbidity and impair quality of life. However, no evidence-based lists of the medications that cause these disorders exist. OBJECTIVE: Our objective was to compile a list of medications affecting salivary gland function and inducing xerostomia or subjective sialorrhea. DATA SOURCES: Electronic databases were searched for relevant articles published until June 2013...
November 16, 2016: Drugs in R&D
https://www.readbyqxmd.com/read/27848234/tolerability-of-capecitabine-monotherapy-in-metastatic-colorectal-cancer-a-real-world-study
#5
Laura W Leicher, Jacques C de Graaf, Wilko Coers, Metin Tascilar, Jan Willem B de Groot
BACKGROUND: Capecitabine monotherapy is a treatment option for selected patients with metastatic colorectal cancer (mCRC) and is administered to up to 17% of patients. Data are limited with regard to adverse events and dosing practices associated with capecitabine monotherapy in real-world situations. OBJECTIVES: The aim of this study was to provide real-world data on adverse event rates and dose adjustments/discontinuations associated with capecitabine monotherapy in patients with mCRC...
November 15, 2016: Drugs in R&D
https://www.readbyqxmd.com/read/27838901/efficacy-of-immunobiologic-and-small-molecule-inhibitor-drugs-for-psoriasis-a-systematic-review-and-meta-analysis-of-randomized-clinical-trials
#6
REVIEW
André Vicente Esteves de Carvalho, Rodrigo Pereira Duquia, Bernardo Lessa Horta, Renan Rangel Bonamigo
BACKGROUND: Psoriasis is an immune-mediated inflammatory disease for which treatment has evolved over the past few years due to the introduction of immunobiologic and small molecule inhibitor medications. A better understanding of the comparative efficacies of drugs may help doctors to choose the most appropriate treatment for patients. OBJECTIVE: The aim of this study was to conduct a systematic review and meta-analysis to assess the efficacy of immunobiologic and small molecule inhibitor drugs for patients with moderate to severe psoriasis...
November 12, 2016: Drugs in R&D
https://www.readbyqxmd.com/read/27830461/acknowledgement-to-referees
#7
(no author information available yet)
No abstract text is available yet for this article.
December 2016: Drugs in R&D
https://www.readbyqxmd.com/read/27798770/impact-of-a-proprietary-standardized-olive-fruit-extract-sofe-on-cardio-ankle-vascular-index-visual-analog-scale-and-c-reactive-protein-assessments-in-subjects-with-arterial-stiffness-risk
#8
Pilar Pais, Agustin Villar, Santiago Rull
INTRODUCTION: The chemical components of olive fruit provide a wide range of cardiovascular benefits. Arterial stiffness is an important cardiovascular risk factor and can be assessed using the Cardio-Ankle Vascular Index (CAVI). OBJECTIVE: The objective of this study was to assess the impact of a proprietary standardized olive fruit extract (SOFE) in subjects at risk for arterial stiffness. METHODS: Twelve of 36 subjects were assigned to each of the following groups for this 11-day, double-blind, placebo-controlled study: Group 1: 250 mg SOFE-50 mg active ingredient, hydroxytyrosol (dosage achieved with two capsules per day); Group 2: 500 mg SOFE-100 mg active ingredient, hydroxytyrosol (dosage achieved with two capsules per day); and Group 3: placebo...
December 2016: Drugs in R&D
https://www.readbyqxmd.com/read/27798769/distinct-glucose-lowering-mechanisms-of-ipragliflozin-depending-on-body-weight-changes
#9
Eiji Kutoh, Teruma Murayama, Asuka Wada, Mitsuru Hirate
BACKGROUND: Sodium-glucose co-transporter 2 inhibitors have been shown to reduce body weight. However, little is known about whether a reduction in body weight affects glycemic and non-glycemic parameters. OBJECTIVES: The aim of this study was to investigate the link between the changes in body weight and those in metabolic parameters in drug-naïve subjects with type 2 diabetes mellitus (T2DM) receiving ipragliflozin monotherapy. METHODS: Subjects received ipragliflozin monotherapy 25-50 mg/day for 3 months (n = 33)...
December 2016: Drugs in R&D
https://www.readbyqxmd.com/read/27770296/lithium-in-bipolar-disorder-optimizing-therapy-using-prolonged-release-formulations
#10
REVIEW
Paolo Girardi, Roberto Brugnoli, Giovanni Manfredi, Gabriele Sani
Lithium has been a gold standard in the treatment of bipolar disorder (BD) for several decades. Despite a general reduction in the use of lithium over the past several years, it is effective in the management of both manic and depressive episodes in BD and continues to be recommended as a first-line mood stabilizer. This review provides an overview of the pharmacology of lithium and highlights its clinical profile in the management of BD, focusing on the potential advantages of prolonged-release (PR) versus immediate-release (IR) formulations of lithium...
December 2016: Drugs in R&D
https://www.readbyqxmd.com/read/27766590/an-updated-overview-on-therapeutic-drug-monitoring-of-recent-antiepileptic-drugs
#11
REVIEW
Shery Jacob, Anroop B Nair
Given the distinctive characteristics of both epilepsy and antiepileptic drugs (AEDs), therapeutic drug monitoring (TDM) can make a significant contribution to the field of epilepsy. The measurement and interpretation of serum drug concentrations can be of benefit in the treatment of uncontrollable seizures and in cases of clinical toxicity; it can aid in the individualization of therapy and in adjusting for variable or nonlinear pharmacokinetics; and can be useful in special populations such as pregnancy. This review examines the potential for TDM of newer AEDs such as eslicarbazepine acetate, felbamate, gabapentin, lacosamide, lamotrigine, levetiracetam, perampanel, pregabalin, rufinamide, retigabine, stiripentol, tiagabine, topiramate, vigabatrin, and zonisamide...
December 2016: Drugs in R&D
https://www.readbyqxmd.com/read/27766589/assessment-of-distal-radius-bone-mineral-density-in-osteoporosis-patients-receiving-denosumab-including-those-with-rheumatoid-arthritis-and-those-receiving-oral-glucocorticoids
#12
Hiroaki Matsuno
BACKGROUND AND OBJECTIVES: Recently, the osteoporosis treatment has attracted attention, and several drugs have been developed. Among these, bisphosphonates (BPs), parathyroid hormone (PTH) and anti-receptor activator of nuclear factor kappa B ligand (RANKL) monoclonal (MAb) denosumab (DMAb) are the major osteoporosis agents. Several studies demonstrated that the effect of osteoporosis agents is evaluated by lumar or hip dual energy X-ray absorptiometry (DXA). However, private clinic commonly use the radial DXA...
December 2016: Drugs in R&D
https://www.readbyqxmd.com/read/27734219/bioequivalence-and-pharmacokinetic-evaluation-study-of-acetaminophen-vs-acetaminophen-plus-caffeine-tablets-in-healthy-mexican-volunteers
#13
Nora Angélica Núñez Guzmán, Daniel Ruiz Molina, Benigno Figueroa Núñez, Juan Carlos Soto-Sosa, Jorge Eduardo Herrera Abarca
OBJECTIVE: The aim of this clinical trial was to establish the bioequivalence of two tablets containing acetaminophen 650 mg (reference) and acetaminophen 650 mg plus caffeine 65 mg (test), administered orally, in fasting conditions in healthy Mexican volunteers. METHODS: Blood samples were taken from 21 male and five female individuals, during a 24-h period, to characterize the pharmacokinetic profile of acetaminophen. Plasma samples were quantified by ultra-performance liquid chromatography, tandem mass spectrometry...
December 2016: Drugs in R&D
https://www.readbyqxmd.com/read/27696306/assessing-the-potential-cost-effectiveness-of-microneedle-patches-in-childhood-measles-vaccination-programs-the-case-for-further-research-and-development
#14
Bishwa B Adhikari, James L Goodson, Susan Y Chu, Paul A Rota, Martin I Meltzer
OBJECTIVE: Currently available measles vaccines are administered by subcutaneous injections and require reconstitution with a diluent and a cold chain, which is resource intensive and challenging to maintain. To overcome these challenges and potentially increase vaccination coverage, microneedle patches are being developed to deliver the measles vaccine. This study compares the cost-effectiveness of using microneedle patches with traditional vaccine delivery by syringe-and-needle (subcutaneous vaccination) in children's measles vaccination programs...
December 2016: Drugs in R&D
https://www.readbyqxmd.com/read/27681888/a-single-dose-escalation-study-to-evaluate-the-safety-and-pharmacokinetics-of-orally-administered-des-aspartate-angiotensin-i-in-healthy-subjects
#15
Ko-Onn Lee, Chin-Meng Khoo, Balram Chowbay, Yiong-Huak Chan, Meng-Kwoon Sim
Des-aspartate-angiotensin I (DAA-I) is an endogenous angiotensin peptide and a prototype angiotensin receptor agonist (ARA). It acts on the angiotensin AT1 receptor and antagonises the deleterious actions of angiotensin II. DAA-I attenuates animal models of human disease in which angiotensin II has been implicated, such as cardiac hypertrophy, neointima formation, arteriosclerosis, renal failure, post-infarction injuries, diabetes, viral infection, chemical-induced inflammation, heat stroke, cancer, and gamma radiation lethality...
December 2016: Drugs in R&D
https://www.readbyqxmd.com/read/27623793/safety-of-mebendazole-use-during-lactation-a-case-series-report
#16
Nour Karra, Rana Cohen, Maya Berlin, Natalie Dinavitser, Gideon Koren, Matitiahu Berkovitch
INTRODUCTION: Mebendazole is an effective drug widely used in the treatment of parasitic infections. Although theoretically considered as safe during lactation, no studies have evaluated its potential adverse effects in infants of breastfeeding mothers. OBJECTIVES: We aimed to evaluate the safety of mebendazole in infants of lactating women treated with the drug. METHODS: Women referred for consultation regarding mebendazole use were invited to participate in the study...
September 2016: Drugs in R&D
https://www.readbyqxmd.com/read/27623792/a-tailored-approach-to-the-treatment-of-a-patient-with-a-severe-dynamic-manifestation-of-rosacea-a-case-report
#17
Martin Schaller, Lena Gonser
Rosacea is a chronic inflammatory disease that can manifest as a spectrum of symptoms including erythema, inflammatory lesions, edema, and telangiectasia. Treatment decisions need to be adapted to reflect the nature and severity of the different symptoms present. In this report, we discuss the case of a female patient diagnosed with severe, inflamed papulopustular rosacea (PPR) presenting with a large number of inflammatory lesions and severe background erythema. This patient responded well to a treatment regimen consisting of a short course of antibiotics in combination with a corticosteroid, followed by monotherapy with isotretinoin to reduce the inflammation...
September 2016: Drugs in R&D
https://www.readbyqxmd.com/read/27550653/effects-of-lemon-and-seville-orange-juices-on-the-pharmacokinetic-properties-of-sildenafil-in-healthy-subjects
#18
Khaled S Abdelkawy, Ahmed M Donia, R Brigg Turner, Fawzy Elbarbry
PURPOSE: Several severe drug interactions have been reported when sildenafil, a potent drug for the treatment of erectile dysfunction, is co-administered with drugs or herbal remedies that inhibit cytochrome P450 (CYP) 3A4. This study evaluates the effects of two citrus fruit juices, lemon and Seville orange, on the pharmacokinetics of sildenafil in male healthy subjects following a single oral dose. METHODS: We conducted an open-label, three-way crossover study in nine healthy male volunteers...
September 2016: Drugs in R&D
https://www.readbyqxmd.com/read/27449765/gastrointestinal-safety-of-aspirin-for-a-high-dose-multiple-day-treatment-regimen-a-meta-analysis-of-three-randomized-controlled-trials
#19
Samantha Forder, Michael Voelker, Angel Lanas
BACKGROUND AND AIM: Aspirin is a commonly used over-the-counter (OTC) agent for the symptomatic treatment of acute pain, fever, or the common cold, but data regarding safety in this context are limited. In order to characterize the safety of aspirin beyond single-dose or long-term use data, we conducted a meta-analysis of multiple-dose, multiple-day studies of OTC aspirin at a label-approved dosage. METHODS: We conducted a meta-analysis of individual patient data from three Bayer-sponsored studies...
September 2016: Drugs in R&D
https://www.readbyqxmd.com/read/27333994/changes-in-levels-of-biomarkers-associated-with-adipocyte-function-and-insulin-and-glucagon-kinetics-during-treatment-with-dapagliflozin-among-obese-type-2-diabetes-mellitus-patients
#20
Aki Okamoto, Hirohide Yokokawa, Hironobu Sanada, Toshio Naito
OBJECTIVES: This study aimed to investigate changes in levels of biomarkers associated with adipocyte function and insulin and glucagon kinetics after a meal tolerance test (MTT) during treatment with dapagliflozin among obese type 2 diabetes mellitus (T2DM) patients. METHODS: T2DM patients with hemoglobin A1c (HbA1c) levels >6.5 % and body mass index (BMI) >25 kg/m(2) were treated with dapagliflozin 5 mg/day for at least 12 weeks. HbA1c, body weight, ketone bodies, adiponectin, plasminogen activator inhibitor-1 (PAI-1), and C-reactive protein (CRP) were measured before and after treatment with dapagliflozin...
June 22, 2016: Drugs in R&D
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