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Bipolar Disorders

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https://www.readbyqxmd.com/read/29024302/reduced-electroencephalogram-responses-to-standard-and-target-auditory-stimuli-in-bipolar-disorder-and-the-impact-of-psychotic-features-analysis-of-event-related-potentials-spectral-power-and-inter-trial-coherence
#1
Nancy B Lundin, Lisa A Bartolomeo, Brian F O'Donnell, William P Hetrick
BACKGROUND: Bipolar disorder (BD) is associated with reductions in the P3b event-related potential (ERP) response to target auditory stimuli, which suggests deficits in context updating. Previous studies have typically examined these responses in the temporal domain, which may not capture alterations in specific frequencies of phase-locked or induced electrophysiological activity. Therefore, the present study examined early and late ERPs in temporal and frequency domains in a bipolar sample with and without current psychotic features...
October 11, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/29024194/disrupted-cortico-limbic-connectivity-during-reward-processing-in-remitted-bipolar-i-disorder
#2
Sunny J Dutra, Vincent Man, Hedy Kober, William A Cunningham, June Gruber
OBJECTIVES: Bipolar disorder (BD) is associated with elevated reward sensitivity and persistent positive affect, yet the neural mechanisms underlying these patterns are not well understood. In the present study, we examined putative disruptions in communication within a well-known cortico-limbic reward circuit during reward processing as a potential contributing mechanism to these symptoms. METHODS: The present investigation employed a within- and between-subjects design utilizing a monetary and social incentive delay task among adults with bipolar disorder type I (BD; N = 24) and a healthy non-psychiatric control group (HC; N = 25) during functional magnetic resonance imaging (fMRI)...
October 11, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28992395/changes-in-white-matter-microstructure-predict-lithium-response-in-adolescents-with-bipolar-disorder
#3
Vivian Kafantaris, Linda Spritzer, Vishal Doshi, Ema Saito, Philip R Szeszko
OBJECTIVES: To investigate whether response to lithium treatment in pediatric bipolar disorder can be predicted by changes in white matter microstructure in key cortico-limbic tracts involved in emotion regulation. METHODS: Eighteen clinically referred lithium-naive patients (mean age 15.5 years) were administered clinical rating scales and diffusion tensor imaging (DTI) examinations at baseline and following 4 weeks of lithium treatment. Clinical ratings were repeated following 8 weeks of treatment...
October 9, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28987022/debate-on-defining-melancholia-a-core-mood-disorder
#4
Lucas Primo de Carvalho Alves, Neusa Sica da Rocha
OBJECTIVES: Recently, a debate article by Parker et al. was published regarding the biological type of depression, melancholia, in which they discussed its clinical presentation, particularly that involving psychomotor disturbances. However, there is one feature of melancholia that is frequently forgotten, to which this article aims to devote special attention: ruminative thoughts of guilt. METHODS: A critical review of the literature. RESULTS: The symptom of ruminative thoughts of guilt has been described historically in melancholia, and some recent data, such as neurobiological abnormalities and poor prognosis, support it as an important feature of depression...
October 7, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28960669/large-scale-network-functional-interactions-during-distraction-and-reappraisal-in-remitted-bipolar-and-unipolar-patients
#5
Giannis Lois, Martin F Gerchen, Peter Kirsch, Philipp Kanske, Sandra Schönfelder, Michèle Wessa
OBJECTIVES: The human brain is organized into large-scale networks that dynamically interact with each other. Extensive evidence has shown characteristic changes in certain large-scale networks during transitions from internally directed to externally directed attention. The aim of the present study was to compare these context-dependent network interactions during emotion regulation and to examine potential alterations in remitted unipolar and bipolar disorder patients. METHODS: We employed a multi-region generalized psychophysiological interactions analysis to quantify connectivity changes during distraction vs reappraisal pair-wise across 90 regions placed throughout the four networks of interest (default-mode, frontoparietal, salience, and dorsal attention networks)...
September 27, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28944987/the-international-society-for-bipolar-disorders-task-force-report-on-pediatric-bipolar-disorder-knowledge-to-date-and-directions-for-future-research
#6
REVIEW
Benjamin I Goldstein, Boris Birmaher, Gabrielle A Carlson, Melissa P DelBello, Robert L Findling, Mary Fristad, Robert A Kowatch, David J Miklowitz, Fabiano G Nery, Guillermo Perez-Algorta, Anna Van Meter, Cristian P Zeni, Christoph U Correll, Hyo-Won Kim, Janet Wozniak, Kiki D Chang, Manon Hillegers, Eric A Youngstrom
OBJECTIVES: Over the past two decades, there has been tremendous growth in research regarding bipolar disorder (BD) among children and adolescents (ie, pediatric BD [PBD]). The primary purpose of this article is to distill the extant literature, dispel myths or exaggerated assertions in the field, and disseminate clinically relevant findings. METHODS: An international group of experts completed a selective review of the literature, emphasizing areas of consensus, identifying limitations and gaps in the literature, and highlighting future directions to mitigate these gaps...
September 25, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28944976/obesity-and-frontal-striatal-brain-structures-in-offspring-of-individuals-with-bipolar-disorder-results-from-the-global-mood-and-brain-science-initiative
#7
Rodrigo B Mansur, Roger S McIntyre, Bo Cao, Yena Lee, Letícia Japiassú, Kun Chen, Rui Lu, Weicong Lu, Xiaodong Chen, Ting Li, Guiyun Xu, Kangguang Lin
OBJECTIVES: To compare frontal-striatal brain volumes between offspring of individuals with bipolar disorder (BD) and healthy controls; to investigate the associations of body mass index (BMI) and age with brain volumes; and to assess the moderating effects of BMI and age on the relationship between risk status and structural brain differences. METHODS: We cross-sectionally assessed structural regional and global brain volumes using magnetic resonance imaging and BMI among 53 BD offspring subjects, stratified by risk status, and 23 non-BD offspring controls (aged 8-28 years)...
September 25, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28941032/are-patients-with-bipolar-disorder-and-comorbid-attention-deficit-hyperactivity-disorder-more-neurocognitively-impaired
#8
Imma Torres, Brisa Sole, Montse Corrales, Esther Jiménez, Sofia Rotger, Juan Francisco Serra-Pla, Irene Forcada, Vanesa Richarte, Ester Mora, Carlos Jacas, Nuria Gómez, Maria Mur, Francesc Colom, Eduard Vieta, Miquel Casas, Anabel Martinez-Aran, Jose M Goikolea, Josep A Ramos-Quiroga
OBJECTIVE: Research on neurocognitive impairment in adult patients with comorbid bipolar disorder (BD) and attention-deficit hyperactivity disorder (ADHD) is very scarce. This study assessed the neurocognitive profile of a comorbid group (BD+ADHD) compared with that of pure BD (pBD) group, pure ADHD (pADHD) group and healthy controls (HCs). METHODS: This was a three-site study comprising 229 subjects: 70 patients with pBD, 23 with BD+ADHD, 50 with pADHD, and 86 HCs...
September 21, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28906586/equivalent-linear-change-in-cognition-between-individuals-with-bipolar-disorder-and-healthy-controls-over-5%C3%A2-years
#9
Kelly A Ryan, Shervin Assari, Kaley Angers, David F Marshall, Kristin Hinrichs, Rebecca Easter, Pallavi Babu, Bethany D Pester, Scott A Langenecker, Melvin G McInnis
OBJECTIVES: Cognitive dysfunction is a key feature of bipolar disorder (BD). However, not much is known about its temporal stability, as some studies have demonstrated a neurodegenerative model in BD while others have shown no change in cognitive functioning over time. Building upon our prior work, which examined the natural course of executive functioning, the current study aimed to investigate the natural course of memory, emotion processing, and fine motor dexterity over a 5-year period in BD and healthy control (HC) samples...
September 14, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28901625/systemic-challenges-in-bipolar-disorder-management-a-patient-centered-approach
#10
Anastasiya Nestsiarovich, Nathaniel G Hurwitz, Stuart J Nelson, Annette S Crisanti, Berit Kerner, Matt J Kuntz, Alicia N Smith, Emma Volesky, Quentin L Schroeter, Jason L DeShaw, S Stanley Young, Robert L Obenchain, Ronald L Krall, Kimmie Jordan, Jan Fawcett, Mauricio Tohen, Douglas J Perkins, Christophe G Lambert
OBJECTIVES: As part of a series of Patient-Centered Outcomes Research Institute-funded large-scale retrospective observational studies on bipolar disorder (BD) treatments and outcomes, we sought the input of patients with BD and their family members to develop research questions. We aimed to identify systemic root causes of patient-reported challenges with BD management in order to guide subsequent studies and initiatives. METHODS: Three focus groups were conducted where patients and their family members (total n = 34) formulated questions around the central theme, "What do you wish you had known in advance or over the course of treatment for BD?" In an affinity mapping exercise, participants clustered their questions and ranked the resulting categories by importance...
September 13, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28944553/outcomes-for-bipolar-patients-assessed-in-the-french-expert-center-network-a-2-year-follow-up-observational-study-fondamental-advanced-centers-of-expertise-for-bipolar-disorder-face-bd
#11
Chantal Henry, Ophelia Godin, Philippe Courtet, Jean-Michel Azorin, Sébastien Gard, Frank Bellivier, Mircea Polosan, Jean-Pierre Kahn, Paul Roux, Valerie Aubin, Dominique Costagliola, Marion Leboyer, Bruno Etain
OBJECTIVE: A new health care system for patients with bipolar disorders was established in France under the auspices of Fondation FondaMental, based on thorough clinical assessment of patients and on close collaborations between expert centers and referring practitioners. We report the results of outcomes after 2 years of observational follow-up of adult patients assessed within the network. METHOD: A total of 984 patients were included in the study. We compared several parameters (e...
September 12, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28895274/methodological-recommendations-for-cognition-trials-in-bipolar-disorder-by-the-international-society-for-bipolar-disorders-targeting-cognition-task-force
#12
REVIEW
K W Miskowiak, K E Burdick, A Martinez-Aran, C M Bonnin, C R Bowie, A F Carvalho, P Gallagher, B Lafer, C López-Jaramillo, T Sumiyoshi, R S McIntyre, A Schaffer, R J Porter, I J Torres, L N Yatham, A H Young, L V Kessing, E Vieta
OBJECTIVES: To aid the development of treatment for cognitive impairment in bipolar disorder, the International Society for Bipolar Disorders (ISBD) convened a task force to create a consensus-based guidance paper for the methodology and design of cognition trials in bipolar disorder. METHODS: The task force was launched in September 2016, consisting of 18 international experts from nine countries. A series of methodological issues were identified based on literature review and expert opinion...
September 12, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28895270/does-a-whiff-of-mania-in-a-major-depressive-episode-shift-treatment-from-a-classical-antidepressant-to-an-atypical-second-generation-antipsychotic
#13
Stephen M Stahl, Debbi Ann Morrissette
No abstract text is available yet for this article.
September 12, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28895269/lithium-and-suicide-in-mood-disorders-updated-meta-review-of-the-scientific-literature
#14
Katharine A Smith, Andrea Cipriani
OBJECTIVES: Suicide and suicidal behaviour are increased in mood disorders, particularly bipolar disorders. Observational studies and small randomized controlled trials (RCTs) support the idea that taking lithium is associated with a reduction in these rates. This paper aims to review the best evidence for the effect of lithium on rates of suicide and self harm. METHODS: We searched PubMed, PsycINFO, and the Cochrane Library systematically for systematic reviews and meta-analyses of RCTs of lithium and suicide and self harm published between January 1980 and June 2017...
September 12, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28895268/lithium-reduces-the-span-of-g-protein-activated-k-girk-channel-inhibition-in-hippocampal-neurons
#15
Nathan Dascal, Moran Rubinstein
OBJECTIVES: Lithium (Li(+) ) is one of the most widely used treatments for bipolar disorder (BD). However, the molecular and neuronal basis of BD, as well as the mechanisms of Li(+) actions are poorly understood. Cellular and biochemical studies identified G proteins as being among the cellular targets for Li(+) action, while genetic studies indicated an association with the KCNJ3 gene, which encodes the G protein-activated inwardly rectifying K(+) (GIRK) channels. GIRK channels regulate neuronal excitability by mediating the inhibitory effects of multiple neurotransmitters and contribute to the resting potassium conductance...
September 12, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28892289/the-need-to-change-from-a-phenomenological-to-a-target-engagement-approach
#16
Mauricio Tohen
No abstract text is available yet for this article.
September 11, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28834020/relationships-between-corpus-callosum-and-language-lateralization-in-patients-with-schizophrenia-and-bipolar-disorders
#17
Maxime Tréhout, Elise Leroux, Nicolas Delcroix, Sonia Dollfus
OBJECTIVES: The question of whether there is a continuum or a dichotomy among patients with schizophrenia (SZ) and bipolar disorders (BD) has not been clearly resolved and remains a challenge. Thus, the identification of specific biomarkers of these disorders might be helpful. The present study investigated the volume of the corpus callosum (CC) and functional lateralization for language as potential biomarkers and their relationships in SZ and BD. METHODS: The study included 20 patients with SZ, 20 patients with BD and 40 healthy controls (HC)...
August 23, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28833984/psychosis-in-bipolar-disorder-does-it-represent-a-more-severe-illness
#18
Cynthia Z Burton, Kelly A Ryan, Masoud Kamali, David F Marshall, Gloria Harrington, Melvin G McInnis, Ivy F Tso
OBJECTIVES: Although there is a common clinical assumption that bipolar disorder with psychotic features reflects greater severity than bipolar disorder without psychosis, the existing empirical literature is mixed. This study investigated the phenomenology of psychosis as well as demographic, clinical, functional, and neuropsychological features in a large, cross-sectional sample of participants with bipolar disorder divided by history of psychosis. METHODS: In a large single study, 168 affective-only bipolar disorder (BP-A) participants and 213 bipolar disorder with a history of psychosis (BP-P) participants completed a comprehensive clinical diagnostic interview and neuropsychological testing...
August 23, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28833966/on-the-centrality-of-mixed-features-in-mood-disorders-listening-to-kraepelin-and-weygandt-and-moving-forward
#19
Andrea Fagiolini, Alessandro Cuomo
No abstract text is available yet for this article.
August 23, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28833953/mixed-state-and-suicide-is-the-effect-of-mixed-state-on-suicidal-behavior-more-than-the-sum-of-its-parts
#20
Jane E Persons, William H Coryell, David A Solomon, Martin B Keller, Jean Endicott, Jess G Fiedorowicz
OBJECTIVE: To assess whether suicidal behavior during mixed states exceeds that expected from the manic or depressive components alone. METHODS: This study included 429 participants with bipolar disorder from the National Institute of Mental Health Collaborative Depression Study (CDS). Mood and suicidal behavior were captured using the Longitudinal Interval Follow-up Evaluation and the Schedule of Affective Disorders and Schizophrenia. Suicidal behavior during each mood state, relative to euthymia, was analyzed using Cox regression to allow for repeated events, with a frailty term to account for intra-participant correlation...
August 23, 2017: Bipolar Disorders
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