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Bipolar Disorders

journal
https://www.readbyqxmd.com/read/28714580/differential-failure-to-deactivate-the-default-mode-network-in-unipolar-and-bipolar-depression
#1
Elena Rodríguez-Cano, Silvia Alonso-Lana, Salvador Sarró, Paloma Fernández-Corcuera, José M Goikolea, Eduard Vieta, Teresa Maristany, Raymond Salvador, Peter J McKenna, Edith Pomarol-Clotet
OBJECTIVES: Neuroimaging studies have revealed evidence of brain functional abnormalities in bipolar depressive disorder (BDD) and major depressive disorder (MDD). However, few studies to date have compared these two mood disorders directly. METHODS: Matched groups of 26 BDD type I patients, 26 MDD patients and 26 healthy controls underwent functional magnetic resonance imaging (fMRI) while performing the n-back working memory task. A whole-brain ANOVA was used to compare the three groups and clusters of significant difference were examined further using region-of-interest (ROI) analysis...
July 17, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28714575/rate-and-predictors-of-conversion-from-unipolar-to-bipolar-disorder-a-systematic-review-and-meta-analysis
#2
REVIEW
Lars Vedel Kessing, Inge Willer, Per Kragh Andersen, Jens Drachman Bukh
OBJECTIVES: For the first time to present a systematic review and meta-analysis of the conversion rate and predictors of conversion from unipolar disorder to bipolar disorder. METHODS: A systematic literature search up to October 2016 was performed. For the meta-analysis, we only included studies that used survival analysis to estimate the conversion rate. RESULTS: A total of 31 studies were identified, among which 11 used survival analyses, including two register-based studies...
July 17, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28714555/evidence-that-eye-movement-profiles-do-not-explain-slow-binocular-rivalry-rate-in-bipolar-disorder-support-for-a-perceptual-endophenotype
#3
Phillip Cf Law, Caroline T Gurvich, Trung T Ngo, Steven M Miller
OBJECTIVES: Presenting conflicting images simultaneously, one to each eye, produces perceptual alternations known as binocular rivalry (BR). Slow BR rate has been proposed as an endophenotype for bipolar disorder (BD) for use in large-scale genome-wide association studies. However, the trait could conceivably reflect eye movement (EM) dysfunction in BD rather than anomalous perceptual processing per se. To address this question, we examined the relationship between EM profiles and BR rate for various stimulus types in BD and healthy subjects...
July 17, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28714553/lithium-in-drinking-water-and-the-incidence-of-bipolar-disorder-a-nation-wide-population-based-study
#4
Lars V Kessing, Thomas A Gerds, Nikoline N Knudsen, Lisbeth F Jørgensen, Søren M Kristiansen, Denitza Voutchkova, Vibeke Ernstsen, Jörg Schullehner, Birgitte Hansen, Per K Andersen, Annette K Ersbøll
OBJECTIVE: Animal data suggest that subtherapeutic doses, including micro doses, of lithium may influence mood, and lithium levels in drinking water have been found to correlate with the rate of suicide. It has never been investigated whether consumption of lithium may prevent the development of bipolar disorder (primary prophylaxis). In a nation-wide population-based study, we investigated whether long-term exposure to micro levels of lithium in drinking water correlates with the incidence of bipolar disorder in the general population, hypothesizing an inverse association in which higher long-term lithium exposure is associated with lower incidences of bipolar disorder...
July 17, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28714547/beyond-symptom-counts-to-case-wise-probabilities
#5
Bernard J Carroll
No abstract text is available yet for this article.
July 17, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28699248/phenotypical-characteristics-of-postpartum-psychosis-a-clinical-cohort-study
#6
Astrid M Kamperman, Marian J Veldman-Hoek, Richard Wesseloo, Emma Robertson Blackmore, Veerle Bergink
OBJECTIVES: Postpartum psychosis (PP) is known for its clear onset but its phenotype has never been clearly described in a cohort. The aim of this study was to describe PP symptomatology, and to identify subgroups of patients based on symptom profiles. METHODS: We prospectively assessed a wide range of symptoms in cases of PP in a cohort of women (N=130) admitted to the Mother-Baby inpatient unit. Using a person-centered analytic approach, we distinguished mutually exclusive subgroups of women...
July 12, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28699182/amygdala-and-hippocampus-volumes-are-differently-affected-by-childhood-trauma-in-patients-with-bipolar-disorders-and-healthy-controls
#7
Delfina Janiri, Gabriele Sani, Pietro De Rossi, Fabrizio Piras, Mariangela Iorio, Nerisa Banaj, Giulia Giuseppin, Edoardo Spinazzola, Matteo Maggiora, Elisa Ambrosi, Alessio Simonetti, Gianfranco Spalletta
OBJECTIVES: Volumetric studies on deep gray matter structures in bipolar disorder (BP) have reported contrasting results. Childhood trauma, a relevant environmental stressor for BP, could account for the variability of the results, modulating differences in the amygdala and hippocampus in patients with BP compared with healthy controls (HC). Our study aimed to test this hypothesis. METHODS: We assessed 105 outpatients, diagnosed with bipolar disorder type I (BP-I) or bipolar disorder type II (BP-II) according to DSM-IV-TR criteria, and 113 HC subjects...
July 12, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28691361/impact-of-childhood-trauma-on-cognitive-profile-in-bipolar-disorder
#8
Esther Jiménez, Brisa Solé, Bárbara Arias, Marina Mitjans, Cristina Varo, María Reinares, Caterina Del Mar Bonnín, Victoria Ruíz, Pilar Alejandra Saiz, M Paz García-Portilla, Patricia Burón, Julio Bobes, Benedikt L Amann, Anabel Martínez-Arán, Carla Torrent, Eduard Vieta, Antoni Benabarre
OBJECTIVES: Bipolar Disorder (BD) is associated with cognitive impairment even during remission periods. Nonetheless, this impairment seems to adjust to different profiles of severity. Our aim was to examine the potential impact of childhood trauma (CT) on cognitive performance and, more specifically, on neurocognitive profile membership. METHODS: Using a data-driven strategy, 113 euthymic bipolar patients were grouped according to their cognitive performance using a hierarchical clustering technique...
July 10, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28691306/to-define-melancholia-follow-the-path-of-catatonia-commentary-by-invitation-on-parker-bassett-outhred-et%C3%A2-al-2017-defining-melancholia-a-core-mood-disorder
#9
https://www.readbyqxmd.com/read/28691278/cognitive-function-treatment-response-to-lithium-and-social-functioning-in-japanese-patients-with-bipolar-disorder
#10
Satoshi Saito, Kumiko Fujii, Yuji Ozeki, Kenichi Ohmori, Gyo Honda, Harunobu Mori, Kazuko Kato, Jinichi Kuroda, Akiko Aoki, Haruhiko Asahi, Hayato Sato, Kazutaka Shimoda, Kazufumi Akiyama
OBJECTIVES: Patients with bipolar disorder often suffer from cognitive impairment that significantly influences their functional outcome. However, it remains unknown whether lithium has a central role in cognition and functional outcome. We examined whether cognition and functional outcome were predicted by demographic and clinical variables, including the response to lithium, in lithium-treated patients with bipolar disorder. METHODS: We evaluated 96 lithium-treated euthymic patients with bipolar disorder and 196 age- and-gender-matched healthy controls, using the Brief Assessment of Cognition in Schizophrenia (BACS)...
July 10, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28691250/obesity-in-patients-with-major-depression-is-related-to-bipolarity-and-mixed-features-evidence-from-the-bridge-ii-mix-study
#11
Eleonora Petri, Olivia Bacci, Margherita Barbuti, Isabella Pacchiarotti, Jean-Michel Azorin, Jules Angst, Charles L Bowden, Sergey Mosolov, Eduard Vieta, Allan H Young, Giulio Perugi
OBJECTIVES: The Bipolar Disorders: Improving Diagnosis, Guidance and Education (BRIDGE)-II-Mix study aimed to estimate the frequency of mixed states in patients with a major depressive episode (MDE) according to different definitions. The present post-hoc analysis evaluated the association between obesity and the presence of mixed features and bipolarity. METHODS: A total of 2811 MDE subjects were enrolled in a multicenter cross-sectional study. In 2744 patients, the body mass index (BMI) was evaluated...
July 10, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28677869/an-epidemiological-profile-of-bipolar-disorder-among-older-adults-with-complex-needs-a-national-cross-sectional-study
#12
Philip J Schluter, Cameron Lacey, Richard J Porter, Hamish A Jamieson
OBJECTIVES: Research on bipolar disorder (BD) among community-living older adults is scant and often suffers from important methodological limitations. Using a national database, this study presents an epidemiological profile of BD in older community residents within New Zealand. METHODS: Since 2012, all New Zealand community care recipients have undergone a standardized needs assessment using the Home Care International Residential Assessment Instrument (interRAI-HC)...
July 5, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28665044/mood-symptoms-in-pregnant-and-postpartum-women-with-bipolar-disorder-a-naturalistic-study
#13
Kara E Driscoll, Dorothy K Y Sit, Eydie L Moses-Kolko, Emily Pinheiro, Amy Yang, Jody D Ciolino, Heather F Eng, James F Luther, Crystal T Clark, Stephen R Wisniewski, Katherine L Wisner
OBJECTIVE: We conducted a prospective naturalistic study of pregnant women with bipolar disorder (BD) to evaluate symptoms of BD across childbearing and assess whether pharmacotherapy reduced their severity. METHODS: Assessments were scheduled at 20, 30, and 36 weeks' gestation and 2, 12, 26, and 52 weeks postpartum. Symptoms were assessed using the Structured Interview Guide for the Hamilton Depression Rating Scale-Atypical Depression Supplement (SIGH-ADS) and Mania Rating Scale (MRS)...
June 30, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28612977/characteristics-of-depression-among-offspring-at-high-and-low-familial-risk-of-bipolar-disorder
#14
Rasim Somer Diler, Tina R Goldstein, Danella Hafeman, Brian Thomas Rooks, Dara Sakolsky, Benjamin I Goldstein, Kelly Monk, Mary Beth Hickey, David Axelson, Satish Iyengar, Boris Birmaher
OBJECTIVES: Having a parent with bipolar disorder (BP) is a very strong risk factor for developing BP. Similarly, depression among youth is a clinical risk factor for subsequent BP. We evaluated whether mood symptomatology in depressed youth is different between those at high and low familial risk to develop BP. METHODS: The most severe major depressive episode in BP offspring (N=61) and community control offspring (N=20) was evaluated using expanded depression and mania rating scales derived from the Schedule for Affective Disorders and Schizophrenia for Children Present Version...
June 14, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28612976/lithium-ameliorates-sleep-deprivation-induced-mania-like-behavior-hypothalamic-pituitary-adrenal-hpa-axis-alterations-oxidative-stress-and-elevations-of-cytokine-concentrations-in-the-brain-and-serum-of-mice
#15
Samira S Valvassori, Wilson R Resende, Gustavo Dal-Pont, Heron Sangaletti-Pereira, Fernanda F Gava, Bruna R Peterle, Roger B Varela, Felipe Dal-Pizzol, João Quevedo
OBJECTIVES: The goal of the present study was to investigate the effects of lithium administration on behavior, oxidative stress parameters and cytokine levels in the periphery and brain of mice subjected to an animal model of mania induced by paradoxical sleep deprivation (PSD). METHODS: Male C57 mice were treated with saline or lithium for 7 days. The sleep deprivation protocol started on the 5th day during for the last 36 hours of the treatment period. Immediately after the sleep deprivation protocol, animals locomotor activity was evaluated and serum and brain samples was extracted to evaluation of corticosterone and adrenocorticotropic hormone circulating levels, oxidative stress parameters and citokynes levels...
June 14, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28605109/a-randomized-double-blind-placebo-and-risperidone-controlled-study-on-valnoctamide-for-acute-mania
#16
Mark Weiser, Linda Levi, Stephen Z Levine, Meir Bialer, Tawfeeq Shekh-Ahmad, Valentin Matei, Alexandru Tiugan, Diana Cirjaliu, Cristinel Sava, Eugenia Sinita, Daisy Zamora, John M Davis
OBJECTIVES: Mood stabilizers administered for bipolar disorder during pregnancy, such as valproic acid, can increase the risk of congenital anomalies in offspring. Valnoctamide is a valproic acid derivative associated with a decreased risk for congenital abnormalities in animals. The present study evaluated the efficacy and safety of valnoctamide monotherapy, compared to placebo, in the treatment of patients in an acute manic episode. METHODS: A 3-week, double-blind, randomized, placebo- and risperidone-controlled, parallel group trial was conducted on 173 patients in an acute manic episode...
June 12, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28593691/psychopharmacological-treatment-of-psychotic-mania-and-psychotic-bipolar-depression-compared-to-non-psychotic-mania-and-non-psychotic-bipolar-depression
#17
Louise B Bjørklund, Henriette T Horsdal, Ole Mors, Christiane Gasse, Søren D Østergaard
OBJECTIVES: An evidence base for the treatment of mania and bipolar depression with psychotic symptoms is lacking. Nevertheless, clinicians may have a preference for treating episodes of bipolar disorder with or without psychotic symptoms in different ways, which is likely to reflect notions of differential efficacy of treatments between these subtypes. This study aimed to investigate whether the psychopharmacological treatment of psychotic and non-psychotic episodes of mania and bipolar depression, respectively, differs in clinical practice...
June 8, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28574189/twenty-year-progression-of-body-mass-index-in-a-county-wide-cohort-of-people-with-schizophrenia-and-bipolar-disorder-identified-at-their-first-episode-of-psychosis
#18
Martin Strassnig, Roman Kotov, Danielle Cornaccio, Laura Fochtmann, Philip D Harvey, Evelyn J Bromet
OBJECTIVE: There is an increased prevalence of obesity in schizophrenia and bipolar disorder, leading to a disproportionate risk of adverse health conditions. Prospective, long-term weight gain data, however, are scarce. METHODS: We analyzed data from the Suffolk County Mental Health Project cohort of consecutive first admissions with psychosis recruited from September 1989 to December 1995 and subsequently followed for 20 years, focusing on people with schizophrenia (n=146) and bipolar disorder (n=87)...
June 2, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28544350/association-between-the-zinc-finger-protein-804a-znf804a-gene-and-the-risk-of-schizophrenia-and-bipolar-i-disorder-across-diagnostic-boundaries
#19
Ji Hyun Baek, Kyooseob Ha, Yongkang Kim, So Yung Yang, Eun-Young Cho, Yujin Choi, Seunghyong Ryu, Yu-Sang Lee, Taesung Park, Kyung Sue Hong
OBJECTIVES: In this study, we aimed to determine the role of genetic variations within the zinc finger protein 804A (ZNF804A) gene, a candidate for a psychosis risk-conferring gene, in the development of schizophrenia (SZ) and bipolar disorder (BP) in the Korean population. METHODS: A total of 921 patients with SZ, bipolar I (BP-I) and II (BP-II) disorder, and 502 control subjects participated in the study. Twenty-one tag single nucleotide polymorphisms (SNPs) across the genomic region of ZNF804A and seven reference SNPs based on previous reports were genotyped...
May 22, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28544121/is-a-delay-in-the-diagnosis-of-bipolar-disorder-inevitable
#20
Kristina Fritz, Alex M T Russell, Christine Allwang, Sandy Kuiper, Lisa Lampe, Gin S Malhi
OBJECTIVE: A diagnosis of bipolar disorder (BD) is often preceded by an initial diagnosis of depression, creating a delay in the accurate diagnosis and treatment of BD. Although previous research has focused on predictors of a diagnosis change from depression to BD, the research on this delay in diagnosis is sparse. Therefore, the present study examined the time taken to make a BD diagnosis following an initial diagnosis of major depressive disorder in order to further understand the patient characteristics and psychological factors that may explain this delay...
May 22, 2017: Bipolar Disorders
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