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Bipolar Disorders

Jodi Lofchy
No abstract text is available yet for this article.
July 18, 2018: Bipolar Disorders
Anne Duffy, Gin S Malhi, Gabrielle A Carlson
No abstract text is available yet for this article.
July 15, 2018: Bipolar Disorders
Leonardo Tondo
No abstract text is available yet for this article.
July 8, 2018: Bipolar Disorders
Samuel Sarrazin, Arnaud Cachia, Franz Hozer, Colm McDonald, Louise Emsell, Dara M Cannon, Michele Wessa, Julia Linke, Amelia Versace, Nora Hamdani, Marc-Antoine D'Albis, Marine Delavest, Mary L Phillips, Paolo Brambilla, Marcella Bellani, Mircea Polosan, Pauline Favre, Marion Leboyer, Jean-François Mangin, Josselin Houenou
OBJECTIVES: Brain sulcation is an indirect marker of neurodevelopmental processes. Studies of the cortical sulcation in bipolar disorder have yielded mixed results, probably due to high variability in clinical phenotype. We investigated whole-brain cortical sulcation in a large sample of selected patients with high neurodevelopmental load. METHODS: A total of 263 patients with bipolar disorder I and 320 controls were included in a multicentric magnetic resonance imaging (MRI) study...
July 6, 2018: Bipolar Disorders
E David Klonsky
No abstract text is available yet for this article.
July 3, 2018: Bipolar Disorders
Rachel Hb Mitchell, Arron Ws Metcalfe, Alvi H Islam, Simina Toma, Ronak Patel, Lisa Fiksenbaum, Daphne Korczak, Bradley J MacIntosh, Benjamin I Goldstein
OBJECTIVES: Bipolar disorder (BD) is twice as prevalent amongst female as amongst male adolescents. Thus far, little is known regarding the neurostructural substrates underlying this disparity. We therefore examined sex differences in neurostructural magnetic resonane imaging (MRI) phenotypes amongst adolescents with BD. METHODS: T1-weighted structural MRI was acquired from 44 BD (25 female [F] and 19 male [M]) and 58 (28 F and 30 M) healthy control (HC) adolescents (13-21 years old)...
June 28, 2018: Bipolar Disorders
Janos L Kalman, Sergi Papiol, Andreas J Forstner, Urs Heilbronner, Franziska Degenhardt, Jana Strohmaier, Mazda Adli, Kristina Adorjan, Nirmala Akula, Martin Alda, Heike Anderson-Schmidt, Till Fm Andlauer, Ion-George Anghelescu, Raffaella Ardau, Bárbara Arias, Volker Arolt, Jean-Michel Aubry, Lena Backlund, Kim Bartholdi, Michael Bauer, Bernhard T Baune, Thomas Becker, Frank Bellivier, Antonio Benabarre, Susanne Bengesser, Abesh Kumar Bhattacharjee, Joanna M Biernacka, Armin Birner, Clara Brichant-Petitjean, Monika Budde, Pablo Cervantes, Caterina Chillotti, Sven Cichon, Scott R Clark, Francesc Colom, Ashley L Comes, Cristiana Cruceanu, Piotr M Czerski, Udo Dannlowski, Alexandre Dayer, Maria Del Zompo, Jay Raymond DePaulo, Detlef E Dietrich, Bruno Étain, Thomas Ethofer, Peter Falkai, Andreas Fallgatter, Christian Figge, Laura Flatau, Here Folkerts, Louise Frisen, Mark A Frye, Janice M Fullerton, Katrin Gade, Sébastien Gard, Julie S Garnham, Fernando S Goes, Maria Grigoroiu-Serbanescu, Anna Gryaznova, Maria Hake, Joanna Hauser, Stefan Herms, Per Hoffmann, Liping Hou, Markus Jäger, Stephane Jamain, Esther Jiménez, Georg Juckel, Jean-Pierre Kahn, Layla Kassem, John Kelsoe, Sarah Kittel-Schneider, Sebastian Kliwicki, Farah Klohn-Sagatholislam, Manfred Koller, Barbara König, Carsten Konrad, Nina Lackner, Gonzalo Laje, Mikael Landén, Fabian U Lang, Catharina Lavebratt, Marion Leboyer, Susan G Leckband, Mario Maj, Mirko Manchia, Lina Martinsson, Michael J McCarthy, Susan L McElroy, Francis J McMahon, Philip B Mitchell, Marina Mitjans, Francis M Mondimore, Palmiero Monteleone, Vanessa Nieratschker, Caroline M Nievergelt, Tomas Novák, Urban Ösby, Andrea Pfennig, James B Potash, Daniela Reich-Erkelenz, Andreas Reif, Jens Reimer, Eva Reininghaus, Markus Reitt, Stephan Ripke, Guy A Rouleau, Janusz K Rybakowski, Martin Schalling, Harald Scherk, Max Schmauß, Peter R Schofield, K Oliver Schubert, Eva C Schulte, Sybille Schulz, Fanny Senner, Giovanni Severino, Tatyana Shekhtman, Paul D Shilling, Christian Simhandl, Claire M Slaney, Carsten Spitzer, Alessio Squassina, Thomas Stamm, Sophia Stegmaier, Sebastian Stierl, Pavla Stopkova, Andreas Thiel, Sarah K Tighe, Alfonso Tortorella, Gustavo Turecki, Eduard Vieta, Julia Veeh, Martin von Hagen, Moritz E Wigand, Jens Wiltfang, Stephanie Witt, Adam Wright, Peter P Zandi, Jörg Zimmermann, Markus Nöthen, Marcella Rietschel, Thomas G Schulze
OBJECTIVES: Bipolar disorder (BD) with early disease onset is associated with an unfavorable clinical outcome and constitutes a clinically and biologically homogenous subgroup within the heterogeneous BD spectrum. Previous studies have found an accumulation of early age at onset (AAO) in BD families and have therefore hypothesized that there is a larger genetic contribution to the early-onset cases than to late onset BD. To investigate the genetic background of this subphenotype, we evaluated whether an increased polygenic burden of BD- and schizophrenia (SCZ)-associated risk variants is associated with an earlier AAO in BD patients...
June 28, 2018: Bipolar Disorders
Anthony J Cleare
No abstract text is available yet for this article.
June 28, 2018: Bipolar Disorders
Emma Gliddon, Victoria Cosgrove, Lesley Berk, Sue Lauder, Mohammadreza Mohebbi, David Grimm, Seetal Dodd, Carolyn Coulson, Karishma Raju, Trisha Suppes, Michael Berk
OBJECTIVES: MoodSwings 2.0 is an online self-guided intervention for bipolar disorder that includes educational modules, interactive tools, and discussion forums. The primary aim of the study was to determine if participation in MoodSwings 2.0 would result in decreased symptoms of depression and mania compared to the control condition. Secondary aims were to identify improvements in core depression symptoms, quality of life, medication adherence, functioning, and time to relapse. METHODS: This was a three-arm randomized controlled trial that compared two intervention arms against a peer support control group (forum)...
June 21, 2018: Bipolar Disorders
Seetal Dodd, Adam J Walker, Alan J M Brnabic, Nancy Hong, Amber Burns, Michael Berk
OBJECTIVES: In the clinical setting, the nocebo phenomenon is where clinical worsening or adverse events occur as a response to a treatment, in a situation in which conditioning from previous treatment exposure and/or expectations of sickness or symptoms lead to sickness and symptoms in a conditioned or expectant individual. The nocebo response may thus be a confounder in clinical treatment and clinical research. There is a need to know how to predict if an individual is likely to be a nocebo responder, and how significant and commonplace the nocebo effect might be...
June 21, 2018: Bipolar Disorders
Robert M Post, Lori L Altshuler, Ralph Kupka, Susan L McElroy, Mark A Frye, Michael Rowe, Heinz Grunze, Trisha Suppes, Paul E Keck, Gabriele S Leverich, Willem A Nolen
INTRODUCTION: Instead of the typical assessment of risk of illness in the offspring based on a parent with bipolar disorder, we explored the potential multigenerational conveyance across several disorders of the vulnerability to illness in the offspring of a patient with bipolar disorder. METHODS: A total of 968 outpatients (average age 41 years) with bipolar illness gave informed consent and filled out a detailed questionnaire about a family history in their parents, grandparents, and offspring of: depression; bipolar disorder; alcohol abuse; substance abuse; suicide attempt; or "other" illness...
June 21, 2018: Bipolar Disorders
Gin S Malhi, Tim Outhred, Amber Hamilton, Grace Morris, Zola Mannie
No abstract text is available yet for this article.
June 21, 2018: Bipolar Disorders
Olivia J Kirtley, Rory C O'Connor
No abstract text is available yet for this article.
June 21, 2018: Bipolar Disorders
Anastasiya Nestsiarovich, Aurélien J Mazurie, Nathaniel G Hurwitz, Berit Kerner, Stuart J Nelson, Annette S Crisanti, Mauricio Tohen, Ronald L Krall, Douglas J Perkins, Christophe G Lambert
OBJECTIVES: This study compared 29 drugs for risk of psychiatric hospitalization in bipolar disorders, addressing the evidence gap on the >50 drugs used by US patients for treatment. METHODS: The Truven Health Analytics MarketScan® database was used to identify 190 894 individuals with bipolar or schizoaffective disorder who filled a prescription for one of 29 drugs of interest: lithium, first- or second-generation antipsychotics, mood-stabilizing anticonvulsants, and antidepressants...
June 19, 2018: Bipolar Disorders
Koen P Grootens, Veronique van Thiel, Erwin G T M Hartong
No abstract text is available yet for this article.
June 17, 2018: Bipolar Disorders
Chantal Henry, Aroldo A Dargél
No abstract text is available yet for this article.
June 13, 2018: Bipolar Disorders
Patricia D Walshaw, Laszlo Gyulai, Michael Bauer, Mark S Bauer, Brian Calimlim, Catherine A Sugar, Peter C Whybrow
OBJECTIVES: This report describes the first comparative double-blind, placebo-controlled trial of levothyroxine (L-T4 ) and triiodothyronine (T3 ) as adjunctive treatments in rapid cycling bipolar disorder. METHODS: Thirty-two treatment-resistant, rapid cycling patients who had failed a trial of lithium were randomized into three treatment arms: L-T4 , T3 , or placebo. They were followed for ≥4 months with weekly clinical and endocrine assessments. RESULTS: There were no statistically significant differences between the groups in age, gender, duration of illness, or thyroid status...
June 4, 2018: Bipolar Disorders
Anda Gershon, Sheri L Johnson, Leigh Thomas, Manpreet K Singh
OBJECTIVES: Both sleep disruption and impulsivity are important predictors of the course of bipolar disorder (BD). Although sleep disruption has been shown to intensify impulsivity, little research has considered how these two important domains interact within BD. Adolescence is a critical period for the onset of BD, and is often associated with increases in impulsivity and substantial changes in sleep. We tested the hypothesis that disruptions in sleep would increase impulsivity among adolescents, and that this effect would be more pronounced among those with BD...
May 20, 2018: Bipolar Disorders
Christopher R Bowie, Michael W Best, Colin Depp, Brent T Mausbach, Thomas L Patterson, Ann E Pulver, Philip D Harvey
OBJECTIVES: Schizophrenia and bipolar disorder overlap considerably. Schizophrenia is a primary psychotic disorder, whereas approximately half of people with bipolar disorder will experience psychosis. In this study, we examined the extent to which cognitive and functional impairments are related to the presence and history of psychosis across the two disorders. METHOD: A total of 633 participants with bipolar disorder I, schizophrenia, and schizoaffective disorder were recruited for a study on the genetics of cognition and functioning in bipolar disorder and schizophrenia...
May 18, 2018: Bipolar Disorders
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