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Bipolar Disorders

Afra van der Markt, Ursula M H Klumpers, Stasja Draisma, Annemiek Dols, Willem A Nolen, Robert M Post, Lori L Altshuler, Mark A Frye, Heinz Grunze, Paul E Keck, Susan L McElroy, Trisha Suppes, Aartjan T F Beekman, Ralph W Kupka
OBJECTIVE: Bipolar disorder has a wide range of clinical manifestations which may progress over time. The aim of this study was to test the applicability of a clinical staging model for bipolar disorder and to gain insight into the nature of the variables influencing progression through consecutive stages. METHODS: Using retrospectively reported longitudinal life chart data of 99 subjects from the Stanley Foundation Bipolar Network Naturalistic Follow-up Study, the occurrence, duration and timely sequence of stages 2 - 4 were determined per month...
November 17, 2018: Bipolar Disorders
Susan Q Shen, Namita Sinha, Richard J Perrin, Nupur Ghoshal, Ammar H Hawasli, Fay Y Womer
No abstract text is available yet for this article.
November 16, 2018: Bipolar Disorders
Giulia Cattarinussi, Annabella Di Giorgio, Robert Christian Wolf, Matteo Balestrieri, Fabio Sambataro
OBJECTIVE: Widespread functional and structural alterations in the brain have been extensively reported in unaffected relatives (RELs) of patients with bipolar disorder (BD) that are at genetic risk for BD. A sufficiently powered meta-analysis of structural (sMRI) and functional magnetic resonance imaging (fMRI) alterations in RELs is still lacking. METHODS: Functional and structural magnetic resonance imaging studies investigating RELs and healthy controls (HCs) published by July 2017 were included in the meta-analyses...
November 16, 2018: Bipolar Disorders
Masanao Shirahama, Takeshi Terao, Koji Hatano, Kentaro Kohno, Hirofumi Hirakawa, Nobuyoshi Ishii
There is evidence to suggest that darkness may have therapeutic effects for mania. For example, darkness therapy with 14 hours of enforced darkness and rest from 6 p.m. to 8 a.m. in a light-sealed isolation room of the ward was proven effective for alleviating manic symptoms in a pilot study1 . Subsequently, a placebo-controlled trial examined the use of blue-blocking (BB) glasses as an add-on treatment for reducing symptoms of mania2 because wearing orange glasses (blue-blockers) in white-light environments has been shown to preserve melatonin production3 ...
November 14, 2018: Bipolar Disorders
Koji Hatano, Takeshi Terao, Takuya Hayashi, Hirofumi Hirakawa, Mayu Makino, Yoshinori Mizokami, Minoru Fujiki, Tsuyoshi Shimomura
OBJECTIVES: Five affective temperaments are regarded as potential precursors of bipolar disorder. These are depressive, cyclothymic, hyperthymic, irritable, and anxious temperaments. However, the neural substrates underlying these temperaments have not been identified. The aim of this study was to determine whether these temperaments are associated with specific neural substrates related to the brain white matter integrity in healthy participants. METHODS: We conducted a cross-sectional neuroimaging study of 71 healthy participants (38 males and 33 females) with affective temperaments...
November 14, 2018: Bipolar Disorders
Francis N Saridin, Sigfried N T M Schouws, Jeroen de Jong, Yolande A L Pijnenburg, Annemiek Dols
C9Orf72 hexanucelotide repeat expansions have been associated with ALS and FTD. Although various psychiatric symptoms have been described in patients with C9Orf72 hexanucleotide repeat expansions, the full clinical spectrum has not yet been elucidated. There is increasing evidence that inflammation plays a role in the disease progression of ALS and FTD (1) and immune dysfunction is strongly associated with bipolar disorder. We present a case in which we hypothesize that inflammation may trigger a secondary mania as an expression of latent FTD/ALS in an older male C9orf72 hexanucleotide repeat expansion carrier...
November 14, 2018: Bipolar Disorders
A Duffy, C Keown-Stoneman, S M Goodday, K Saunders, J Horrocks, P Grof, A Weir, C Hinds, J Geddes
OBJECTIVES: To determine the compliance and clinical utility of weekly and daily mood symptom monitoring in adolescents and young adults at risk for mood disorder. METHODS: Fifty emerging adult offspring of bipolar parents were recruited from the Flourish Canadian high-risk cohort study along with 108 university student controls. Participants were assessed by KSADS/SADS-L semi-structured interviews and used a remote capture method to complete weekly and daily mood symptom ratings using validated scales for 90 consecutive days...
November 13, 2018: Bipolar Disorders
David J Bond, Wayne Su, William G Honer, Taj Dhanoa, Tegan Batres-Y-Carr, Susanne S Lee, Ivan J Torres, Raymond W Lam, Lakshmi N Yatham
OBJECTIVES: A sizable fraction of people with bipolar I disorder (BDI) experience a deteriorating clinical course with increasingly frequent mood episodes and chronic disability. This is believed to result from neurobiological illness progression, or neuroprogression. Excessive weight gain predicts neuroprogression across multiple brain illnesses, but no prospective studies have investigated this in BDI. The objective of this study was to determine whether BDI patients who experienced clinically significant weight gain (CSWG; gaining ≥7% of baseline weight) over 12 months had greater 12-month brain volume loss in frontal and temporal regions important to BDI...
November 13, 2018: Bipolar Disorders
Rakshathi Basavaraju, Urvakhsh Meherwan Mehta, Alvaro Pascual-Leone, Jagadisha Thirthalli
OBJECTIVES: The role of the 'mirror neuron system' (MNS) in the pathophysiology of mood disorders is not well studied. Given its posited role in the often-impaired socio-emotional processes like intention detection, empathy, and imitation, we compared putative MNS-activity in patients with bipolar mania and healthy comparison subjects. We also examined the association between putative MNS-activity and hyper-imitative behaviors in patients. METHODS: We studied 39 medication-free individuals diagnosed with mania and 45 healthy comparison subjects...
November 13, 2018: Bipolar Disorders
Adam L Urback, Arron W S Metcalfe, Daphne J Korczak, Bradley J MacIntosh, Benjamin I Goldstein
OBJECTIVES: Cardiovascular disease (CVD) is excessive and premature among individuals with bipolar disorder (BD). Cerebrovascular reactivity (CVR), reflecting vasodilatory capacity of cerebral blood vessels in response to vasoactive substances, is a marker of cerebrovascular health. Despite informative findings in other diseases, CVR has not previously been examined in BD. METHODS: Twenty-five adolescents with BD and 25 age and sex-matched psychiatrically healthy controls (HCs) completed six 15-second breath-holds (BHs) during functional magnetic resonance imaging (fMRI) at 3-Tesla...
November 13, 2018: Bipolar Disorders
Jeffrey M Spielberg, Melanie A Matyi, Harish Karne, Amit Anand
OBJECTIVES: Lithium is one of the most effective and specific treatments for bipolar disorder (BP), but the neural mechanisms by which lithium impacts symptoms remain unclear. Past research has been limited by a reliance on cross-sectional designs, which does not allow for identification of within-person changes due to lithium and has not examined communication between brain regions (i.e., networks). In the present study, we prospectively investigated the lithium monotherapy associated effects in vivo on the brain connectome in medication-free BP patients...
November 12, 2018: Bipolar Disorders
Asta R Prajapati, Jon Wilson, Fujian Song, Ian Maidment
BACKGROUND: Non-adherence is a significant problem in bipolar disorder. Second-generation antipsychotics (SGA) long-acting injections (LAIs) may improve adherence in bipolar disorder and may prevent relapses. However, the evidence is limited and conflicting. OBJECTIVE: The objective of this study was to evaluate efficacy and safety of SGA LAIs in bipolar disorder. METHOD: Systematic review and meta-analysis of randomised controlled trials (RCTs) (≥6 months duration) investigating safety and efficacy of SGA LAIs for bipolar disorder...
November 11, 2018: Bipolar Disorders
Roger S McIntyre
The article by Petri et al. provides a compelling reason to believe that obesity is a probabilistic factor for bipolar spectrum disorders (i.e. factors that associate with a higher probability for Bipolar Disorder)(1). Briefly, investigators post-hoc analyzed data from The Bipolar Disorders: Improving Diagnosis, Guidance and Education (BRIDGE)-II-Mix study wherein they sought to determine whether an association exists between mixed features and bipolarity amongst adults with a major depressive episode (MDE)...
November 9, 2018: Bipolar Disorders
Anna Van Meter, Victoria E Cosgrove
Gliddon et al.1 adds to a compelling evidence base suggesting that digital interventions like MoodSwings 2.0 have the potential to contribute to long-lasting, clinically meaningful reductions in depression for adults with bipolar disorder (BD). Like MoodSwings, most digital interventions are essentially evidence-based psychosocial programs adapted for online delivery. Some include interaction with a clinician, whereas others are entirely self-guided. From a public health perspective, the allure of empirically-valid digital interventions for BD is considerable; a majority of psychosocial interventions with an evidence base in BD have not been disseminated widely and are principally available at research institutions where they were developed...
November 2, 2018: Bipolar Disorders
Ida Behrendt-Møller, Trine Madsen, Holger Jelling Sørensen, Louisa Sylvia, Edward S Friedman, Richard C Shelton, Charles L Bowden, Joseph R Calabrese, Susan L McElroy, Terence A Ketter, Noreen A Reilly Harrington, Keming Gao, Michael Thase, William V Bobo, Mauricio Tohen, Melvin McInnis, Masoud Kamali, James H Kocsis, Thilo Deckersbach, Ole Köhler-Forsberg, Andrew A Nierenberg
INTRODUCTION: Depressive episodes are often prevalent among patients with bipolar disorder, but little is known regarding the differential patterns of development over time. We aimed to determine and characterize trajectories of depressive symptoms among adults with bipolar disorder during 6 months of systematic treatment. METHOD: The pragmatic clinical trial, Bipolar Clinical Health Outcomes Initiative in Comparative Effectiveness (CHOICE) randomized 482 outpatients with bipolar disorder to lithium or quetiapine...
November 1, 2018: Bipolar Disorders
Bruno Etain, Frank Bellivier
No abstract text is available yet for this article.
October 30, 2018: Bipolar Disorders
Kenneth I Shulman, Osvaldo P Almeida, Nathan Herrmann, Ayal Schaffer, Sergio A Strejilevich, Christina Paternoster, Sean Amodeo, Annemiek Dols, Martha Sajatovic
OBJECTIVES: Despite the growing numbers and proportion of older adults with bipolar disorder (OABD), there are very limited guidelines for the use of lithium with its double-edged potential for effectiveness and toxicity in this population. The primary aims of this Delphi survey were: (a) To determine the place of lithium among the preferred choices for maintenance treatment of OABD. (b) To provide detailed clinical guidelines for the safe and effective use of lithium in OABD. METHODS: In the face of limited evidence, the Delphi survey method was used to achieve consensus by a group of 25 experts in OABD from nine countries...
October 30, 2018: Bipolar Disorders
Judit Simon, John R Geddes, Alexandra Gardiner, Jennifer Rendell, Guy M Goodwin, Susanne Mayer
OBJECTIVES: Although not licensed for acute bipolar depression, lamotrigine has evidence for efficacy in trials and its use is recommended in guidelines. So far there had been no prospective health economic evaluation of its use. METHODS: Cost-utility analysis of the CEQUEL trial comparing quetiapine plus lamotrigine versus quetiapine monotherapy (and folic acid versus placebo in an add-on factorial design) for patients with bipolar depression (n=201) from the health and social care perspective...
October 30, 2018: Bipolar Disorders
Pedro Miguel Dos Santos Oliveira, Vítor Santos, Manuel Coroa, Joana Ribeiro, Nuno Madeira
OBJECTIVES: There are no well-established biomarkers to predict the risk of conversion to bipolar disorder (BD) in patients with depression. Given the putative role of purinergic neurotransmission dysfunction in BD, the purpose of our study was to evaluate if higher serum uric acid (UA) levels could predict BD conversion in depressed inpatients. METHODS: We reviewed retrospectively the records of subjects hospitalized between June 2007 and June 2010 with a diagnosis of major depressive disorder (MDD) who had undergone routine UA levels testing at admission...
October 30, 2018: Bipolar Disorders
Felice N Jacka
No abstract text is available yet for this article.
October 25, 2018: Bipolar Disorders
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