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Bipolar Disorders

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https://www.readbyqxmd.com/read/27933713/antipsychotic-adjunctive-therapy-to-mood-stabilizers-and-1-year-rehospitalization-rates-in-bipolar-disorder-a-cohort-study
#1
Eldar Hochman, Amir Krivoy, Ayal Schaffer, Abraham Weizman, Avi Valevski
OBJECTIVES: Antipsychotic adjunctive therapy to mood stabilizers (MSs) may improve relapse prevention; however, only a few naturalistic studies, reflecting more generalizable bipolar disorder (BD) samples, support this notion. We compared the 1-year rehospitalization rates of manic patients with bipolar I disorder (BD-I) who were discharged with MS (lithium or valproate) monotherapy or with adjunctive atypical or typical antipsychotic therapy. METHODS: A total of 201 patients with BD-I who were hospitalized with manic episodes between 2005 and 2013 were retrospectively followed for 1-year rehospitalization rates according to treatment at discharge: MS monotherapy, MS with atypical antipsychotics, and MS with typical antipsychotics...
December 9, 2016: Bipolar Disorders
https://www.readbyqxmd.com/read/27933696/commentary-on-blue-blocking-glasses-as-additive-treatment-for-mania-a-randomized-placebo-controlled-trial
#2
Amílcar Silva-Dos-Santos
No abstract text is available yet for this article.
December 9, 2016: Bipolar Disorders
https://www.readbyqxmd.com/read/27900801/gsk-3-a-key-regulatory-target-for-ketamine-s-rapid-antidepressant-effects-mediated-by-enhanced-ampa-to-nmda%C3%A2-throughput
#3
Carlos A Zarate, Rodrigo Machado-Vieira
No abstract text is available yet for this article.
November 29, 2016: Bipolar Disorders
https://www.readbyqxmd.com/read/27882645/long-term-lithium-treatment-increases-intracellular-and-extracellular-brain-derived-neurotrophic-factor-bdnf-in-cortical-and-hippocampal-neurons-at-subtherapeutic-concentrations
#4
Vanessa J De-Paula, Wagner F Gattaz, Orestes V Forlenza
OBJECTIVES: The putative neuroprotective effects of lithium treatment rely on the fact that it modulates several homeostatic mechanisms involved in the neurotrophic response, autophagy, oxidative stress, inflammation, and mitochondrial function. Lithium is a well-established therapeutic option for the acute and long-term management of bipolar disorder and major depression. The aim of this study was to evaluate the effects of subtherapeutic and therapeutic concentrations of chronic lithium treatment on brain-derived neurotrophic factor (BDNF) synthesis and secretion...
November 24, 2016: Bipolar Disorders
https://www.readbyqxmd.com/read/27882644/sleep-wake-cycle-phenotypes-in-young-people-with-familial-and-non-familial-mood-disorders
#5
Jan Scott, Sharon Naismith, Ashlee Grierson, Joanne Carpenter, Daniel Hermens, Elizabeth Scott, Ian Hickie
OBJECTIVES: Converging evidence identifies that the offspring of parents with bipolar disorder (BD), individuals at clinical high risk of BD, and young people with recent onset BD may differ from other clinical cases or healthy controls in terms of sleep-wake profiles. However, it is possible that these differences may reflect current mental state, subtype of mood disorder, or familial traits. This study aimed to determine objective and subjective sleep-wake profiles in individuals aged 15-25 years with a current major depressive episode, in relation to familial traits...
November 24, 2016: Bipolar Disorders
https://www.readbyqxmd.com/read/27864917/genetic-variation-in-the-mir-708-gene-and-its-binding-targets-in-bipolar-disorder
#6
Alessia Fiorentino, Niamh Louise O'Brien, Sally Isabel Sharp, David Curtis, Nicholas James Bass, Andrew McQuillin
OBJECTIVE: rs12576775 was found to be associated with bipolar disorder (BD) in a genome-wide association study (GWAS). The GWAS signal implicates genes for the microRNAs miR-708 and miR-5579 and the first exon of the Odd Oz/ten-m homolog 4 gene (ODZ4). In the present study, miR-708, its surrounding region, and its targets were analyzed for potential BD-associated functional variants. METHODS: The miR-708 gene and surrounding regions were screened for variation using high-resolution melting (HRM) analysis in 1099 cases of BD, followed by genotyping of rare variants in an enlarged sample of 2078 subjects with BD, 1303 subjects with schizophrenia, and 1355 healthy controls...
November 16, 2016: Bipolar Disorders
https://www.readbyqxmd.com/read/27650468/a-population-based-study-of-the-comparative-effectiveness-of-second-generation-antipsychotics-vs-older-antimanic-agents-in-bipolar-disorder
#7
Mark S Bauer, Christopher J Miller, Mingfei Li, Laura A Bajor, Austin Lee
OBJECTIVES: Numerous antimanic treatments have been introduced over the past two decades, particularly second-generation antipsychotics (SGAs). However, it is not clear whether such newer agents provide any advantage over older treatments. METHODS: A historical cohort design investigated the nationwide population of outpatients with bipolar disorder treated in the Department of Veterans Affairs who were newly initiated on an antimanic agent between 2003 and 2010 (N=27 727)...
September 21, 2016: Bipolar Disorders
https://www.readbyqxmd.com/read/27650399/the-effects-of-cigarette-smoking-behavior-and-psychosis-history-on-general-and-social-cognition-in-bipolar-disorder
#8
Luz H Ospina, Manuela Russo, George M Nitzburg, Armando Cuesta-Diaz, Megan Shanahan, Mercedes M Perez-Rodriguez, Meaghan Mcgrath, Hannah Levine, Sandra Mulaimovic, Katherine E Burdick
OBJECTIVES: Several studies have documented the prevalence and effects of cigarette smoking on cognition in psychotic disorders; fewer have focused on bipolar disorder (BD). Cognitive and social dysfunction are common in BD, and the severity of these deficits may be related both to illness features (e.g., current symptoms, psychosis history) and health-related behaviors (e.g., smoking, alcohol use). The current study assessed the influence of cigarette smoking on general and social cognition in a BD cohort, accounting for illness features with a focus on psychosis history...
September 21, 2016: Bipolar Disorders
https://www.readbyqxmd.com/read/27647671/fmri-brain-activation-changes-following-treatment-of-a-first-bipolar-manic-episode
#9
Stephen M Strakowski, David E Fleck, Jeffrey Welge, James C Eliassen, Matthew Norris, Michelle Durling, Richard A Komoroski, Wen-Jang Chu, Wade Weber, Jonathan A Dudley, Thomas J Blom, Amanda Stover, Christina Klein, Jeffrey R Strawn, Melissa P DelBello, Jing-Huei Lee, Caleb M Adler
OBJECTIVES: We tested the hypothesis that, with treatment, functional magnetic resonance imaging (fMRI) regional brain activation in first-episode mania would normalize - i.e., that differences from healthy subjects would diminish over time, and would be associated with clinical remission status, potentially identifying neuroanatomic treatment response markers. METHODS: Forty-two participants with bipolar I disorder were recruited during their first manic episode, pseudo-randomized to open-label lithium or quetiapine, and followed for 8 weeks...
September 19, 2016: Bipolar Disorders
https://www.readbyqxmd.com/read/27628748/vestibular-neuromodulation-stimulating-the-neural-crossroads-of-psychiatric-illness
#10
Steven M Miller
No abstract text is available yet for this article.
September 14, 2016: Bipolar Disorders
https://www.readbyqxmd.com/read/27870507/stress-and-reward-processing-in-bipolar-disorder-a-functional-magnetic-resonance-imaging-study
#11
Lisa H Berghorst, Poornima Kumar, Doug N Greve, Thilo Deckersbach, Dost Ongur, Sunny J Dutra, Diego A Pizzagalli
OBJECTIVES: A link between negative life stress and the onset of mood episodes in bipolar disorder (BD) has been established, but processes underlying such a link remain unclear. Growing evidence suggests that stress can negatively affect reward processing and related neurobiological substrates, indicating that a dysregulated reward system may provide a partial explanation. The aim of this study was to test the impact of stress on reward-related neural functioning in BD. METHODS: Thirteen euthymic or mildly depressed individuals with BD and 15 controls performed a Monetary Incentive Delay (MID) task while undergoing functional magnetic resonance imaging during no-stress and stress (negative psychosocial stressor involving poor performance feedback and threat of monetary deductions) conditions...
November 2016: Bipolar Disorders
https://www.readbyqxmd.com/read/27870506/differential-neurometabolite-alterations-in-brains-of-medication-free-individuals-with-bipolar-disorder-and-those-with-unipolar-depression-a-two-dimensional-proton-magnetic-resonance-spectroscopy-study
#12
Hui Li, Haiyun Xu, Yinnan Zhang, Jitian Guan, Jie Zhang, Chongtao Xu, Zhiwei Shen, Bo Xiao, Chunlian Liang, Kaiyuan Chen, Jinling Zhang, Renhua Wu
OBJECTIVES: Bipolar disorder (BD) is a mental disorder characterized by periods of elevated mood and depression. Many individuals with BD are initially misdiagnosed and treated for unipolar depression (UD). In this study, we report direct comparisons between medication-free individuals with BD and those with UD in terms of the neurometabolites in the anterior cingulate cortex (ACC), medial prefrontal cortex (mPFC), parietal cortex (PC), and posterior cingulate cortex (PCC) of the brain...
November 2016: Bipolar Disorders
https://www.readbyqxmd.com/read/27870505/distinguishing-medication-free-subjects-with-unipolar-disorder-from-subjects-with-bipolar-disorder-state-matters
#13
Maria M Rive, Ronny Redlich, Lianne Schmaal, André F Marquand, Udo Dannlowski, Dominik Grotegerd, Dick J Veltman, Aart H Schene, Henricus G Ruhé
OBJECTIVES: Recent studies have indicated that pattern recognition techniques of functional magnetic resonance imaging (fMRI) data for individual classification may be valuable for distinguishing between major depressive disorder (MDD) and bipolar disorder (BD). Importantly, medication may have affected previous classification results as subjects with MDD and BD use different classes of medication. Furthermore, almost all studies have investigated only depressed subjects. Therefore, we focused on medication-free subjects...
November 2016: Bipolar Disorders
https://www.readbyqxmd.com/read/27870504/chronic-licl-pretreatment-suppresses-thrombin-stimulated-intracellular-calcium-mobilization-through-trpc3-in-astroglioma-cells
#14
Takuji Uemura, Marty Green, Jerry J Warsh
OBJECTIVES: Transient receptor potential canonical type 3 (TRPC3) channels are activated in B lymphoblast cell lines from patients with bipolar disorder (BD), and its expression is reduced by chronic lithium treatment, implicating TRPC3 in the intracellular calcium (Ca(2+) ) dyshomeostasis of BD. Thrombin, via a protease-activated receptor, moderates Ca(2+) signaling and TRPC3 in astrocytes, and also cell proliferation. We examined whether lithium pretreatment attenuates thrombin-stimulated TRPC3 expression and function in astrocytes, and levels of the calcium-binding peptide, S100B, which is expressed mainly in these cells...
November 2016: Bipolar Disorders
https://www.readbyqxmd.com/read/27813234/differential-neural-correlates-of-autobiographical-memory-recall-in-bipolar-and-unipolar-depression
#15
Kymberly D Young, Jerzy Bodurka, Wayne C Drevets
OBJECTIVES: Autobiographical memory (AM) recall is impaired in both bipolar depression (BD) and major depressive disorder (MDD). The current study used functional magnetic resonance imaging (fMRI) to investigate differences between healthy controls (HCs) and depressed participants with either BD or MDD as they recalled AMs that varied in emotional valence. METHODS: Unmedicated adults in a current major depressive episode who met criteria for either MDD or BD and HCs (n=16/group) underwent fMRI while recalling AMs in response to emotionally valenced cue words...
November 2016: Bipolar Disorders
https://www.readbyqxmd.com/read/27805299/step-wise-loss-of-antidepressant-effectiveness-with-repeated-antidepressant-trials-in-bipolar-ii-depression
#16
Jay D Amsterdam, Lorenzo Lorenzo-Luaces, Robert J DeRubeis
OBJECTIVE: This study examined the relationship between the number of prior antidepressant treatment trials and step-wise increase in pharmacodynamic tolerance (or progressive loss of effectiveness) in subjects with bipolar II depression. METHODS: Subjects ≥18 years old with bipolar II depression (n=129) were randomized to double-blind venlafaxine or lithium carbonate monotherapy for 12 weeks. Responders (n=59) received continuation monotherapy for six additional months...
November 2016: Bipolar Disorders
https://www.readbyqxmd.com/read/27782355/pain-processing-abnormalities-in-bipolar-i-disorder-bipolar-ii-disorder-and-schizophrenia-a-novel-trait-marker-for-psychosis-proneness-and-functional-outcome
#17
Amedeo Minichino, Roberto Delle Chiaie, Giorgio Cruccu, Serena Piroso, Giulia Di Stefano, Marta Francesconi, Francesco Saverio Bersani, Massimo Biondi, Andrea Truini
OBJECTIVES: Overlapping neural system dysfunctions, mainly involving the secondary somatosensory cortex (S2), the anterior cingulate cortex (ACC) and the anterior insular cortex (AIC), seem to be related to both pain-perception abnormalities and psychotic symptoms in schizophrenia (SCZ) and bipolar disorder (BD). Laser-evoked potentials (LEPs) were used to investigate pain-perception and central pain-processing abnormalities in SCZ, bipolar I disorder (BD-I), and bipolar II disorder (BD-II), and to evaluate their relationship with history of psychosis, and social-cognitive and functional impairments...
November 2016: Bipolar Disorders
https://www.readbyqxmd.com/read/27759214/neuroprogression-and-episode-recurrence-in-bipolar-i-disorder-a-study-of-gray-matter-volume-changes-in-first-episode-mania-and-association-with-clinical-outcome
#18
Jan-Marie Kozicky, Alexander McGirr, David J Bond, Marjorie Gonzalez, Leonardo E Silveira, Kamyar Keramatian, Ivan J Torres, Raymond W Lam, Lakshmi N Yatham
OBJECTIVES: Bipolar I disorder (BD-I) is associated with gray matter volume (GMV) alterations in neural regions important for emotional regulation. Reductions found in patients with multiple episodes are not seen at illness onset, suggesting that changes occur with illness progression, although no prospective studies to date have examined this. In the present study, we assessed GMV at baseline and one year following a first manic episode, examining the impact of episode recurrence on the trajectory of change...
September 2016: Bipolar Disorders
https://www.readbyqxmd.com/read/27759213/early-report-on-brain-arousal-regulation-in-manic-vs-depressive-episodes-in-bipolar-disorder
#19
Dirk Alexander Wittekind, Janek Spada, Alexander Gross, Tilman Hensch, Philippe Jawinski, Christine Ulke, Christian Sander, Ulrich Hegerl
OBJECTIVES: The arousal regulation model of affective disorders attributes an important role in the pathophysiology of affective disorders to dysregulation of brain arousal regulation. According to this model, sensation avoidance and withdrawal in depression and sensation seeking and hyperactivity in mania can be explained as auto-regulatory attempts to counteract a tonically high (depression) or unstable (mania) arousal. The aim of this study was to compare brain arousal regulation between manic and depressive bipolar patients and healthy controls...
September 2016: Bipolar Disorders
https://www.readbyqxmd.com/read/27759212/replication-of-genome-wide-association-study-gwas-susceptibility-loci-in-a-latino-bipolar-disorder-cohort
#20
Suzanne Gonzalez, Jayanta Gupta, Erika Villa, Indika Mallawaarachchi, Marco Rodriguez, Mercedes Ramirez, Juan Zavala, Regina Armas, Albana Dassori, Javier Contreras, Deborah Flores, Alvaro Jerez, Alfonso Ontiveros, Humberto Nicolini, Michael Escamilla
OBJECTIVES: Recent genome-wide association studies (GWASs) have identified numerous putative genetic polymorphisms associated with bipolar disorder (BD) and/or schizophrenia (SC). We hypothesized that a portion of these polymorphisms would also be associated with BD in the Latino American population. To identify such regions, we tested previously identified genetic variants associated with BD and/or SC and ancestral haploblocks containing these single nucleotide polymorphisms (SNPs) in a sample of Latino subjects with BD...
September 2016: Bipolar Disorders
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