Fana Alem Kidane, Lena Müller, Marianne Rocha-Hasler, Aldine Tu, Victoria Stanek, Nicholas Campion, Tina Bartosik, Mohammed Zghaebi, Slagjana Stoshikj, Daniela Gompelmann, Andreas Spittler, Marco Idzko, Julia Eckl-Dorna, Sven Schneider
Chronic rhinosinusitis (CRS) is a persistent nasal and paranasal sinus mucosa inflammation comprising two phenotypes, namely CRS with nasal polyps (CRSwNP) and without (CRSsNP). CRSwNP can be associated with asthma and hypersensitivity to non-steroidal anti-inflammatory drugs (NSAIDs) in a syndrome known as NSAID-exacerbated respiratory disease (N-ERD). Furthermore, CRS frequently intertwines with respiratory allergies. This study investigated levels of 33 different nasal and serum cytokines and phenotypic characteristics of peripheral blood mononuclear cells (PBMCs) within cohorts of CRS patients (n = 24), additionally examining the influence of comorbid respiratory allergies by mass cytometry...
March 8, 2024: Clinical Immunology: the Official Journal of the Clinical Immunology Society