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Diabetes/metabolism Research and Reviews

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https://www.readbyqxmd.com/read/28103417/diabetes-as-a-risk-factor-for-acute-coronary-syndrome-in-women-compared-with-men-a-meta-analysis-including-10-856-279-individuals-and-106-703-acute-coronary-syndrome-events
#1
Xue Dong, Rongrong Cai, Jie Sun, Rong Huang, Pin Wang, Haixia Sun, Sai Tian, Shaohua Wang
BACKGROUND: Diabetes mellitus is a significant cause of death and disability worldwide and is a strong risk factor for acute coronary syndrome (ACS). Whether diabetes confers the same excess risk of ACS in both sexes is unknown. Therefore, we undertook a meta-analysis to estimate the relative risk for ACS associated with diabetes in men and women. METHODS: We systematically searched PubMed, Embase, and Cochrane Library databases for both case-control and cohort studies published between Jan 1, 1966, and Jan 1, 2015...
January 19, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28099783/ketosis-and-diabetic-ketoacidosis-in-response-to-sglt2-inhibitors-basic-mechanisms-and-therapeutic-perspectives
#2
REVIEW
Hongyu Qiu, Aleksandra Novikov, Volker Vallon
Inhibitors of the sodium-glucose cotransporter SGLT2 are a new class of anti-hyperglycemic drugs that have been approved for the treatment of type 2 diabetes mellitus (T2DM). These drugs inhibit glucose reabsorption in the proximal tubules of the kidney thereby enhancing glucosuria and lowering blood glucose levels. Additional consequences and benefits include a reduction in body weight, uric acid levels, and blood pressure. Moreover, SGLT2 inhibition can have protective effects on the kidney and cardiovascular system in patients with T2DM and high cardiovascular risk...
January 18, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28072911/potential-protective-effect-of-lactation-against-incidence-of-type-2-diabetes-in-women-with-previous-gestational-diabetes-mellitus-a-systematic-review-and-meta-analysis
#3
REVIEW
Kanako Tanase-Nakao, Naoko Arata, Maki Kawasaki, Ichiro Yasuhi, Hirohito Sone, Rintaro Mori, Erika Ota
BACKGROUND: Lactation may protect women with previous gestational diabetes mellitus (GDM) from developing type 2 diabetes, but the results of existing studies are inconsistent, ranging from null to beneficial. We aimed to conduct a systematic review to gather available evidence. METHODS: Databases MEDLINE, CINAHL, PubMed and EMBASE were searched on 15 December 2015 without restriction of language or publication year. A manual search was also conducted. We included observational studies (cross-sectional, case-control and cohort study) with information on lactation and type 2 diabetes incidence among women with previous GDM...
January 10, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28067472/efficacy-of-basal-bolus-insulin-regimens-in-the-inpatient-management-of-non-critically-ill-patients-with-type-2-diabetes-a-systematic-review-and-meta-analysis
#4
REVIEW
Merete B Christensen, Anders Gotfredsen, Kirsten Nørgaard
BACKGROUND: Hyperglycemia during hospitalization is associated with increased rates of complications and longer hospital stays. Various insulin regimens are used in the inpatient diabetes management of non-critically ill patients. We aimed to assess the efficacy and safety of basal-bolus insulin therapy (BBI) by summarizing evidence from studies of BBI versus sliding scale insulin therapy (SSI) in the management of hospitalized non-critically ill type 2 diabetes patients. METHODS: We searched MEDLINE, EMBASE, Scopus and the Cochrane Library for studies comparing BBI therapy with SSI therapy in hospitalized non-critically ill patients with type 2 diabetes...
January 9, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28063267/diabetes-glycemia-and-risk-of-post-operative-cognitive-dysfunction-a-meta-analysis
#5
I Feinkohl, G Winterer, T Pischon
BACKGROUND: Post-operative cognitive dysfunction (POCD) occurs frequently after surgery, particularly among older people. Diabetes, chronic hyperglycemia and a history of hypoglycemia are related to cognitive impairment, but little is known about their roles in POCD. Here, we estimated their associations with risk of POCD on the basis of published epidemiological research. METHODS: The PubMed and Cochrane databases were searched for longitudinal studies of adults undergoing surgery with reporting of associations of diabetes status, glycemic levels and/or a history of hypoglycemia with risk of POCD as relative risks or odds ratios...
January 7, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28054743/hypoglycemia-evaluation-and-reporting-in-diabetes-importance-for-the-development-of-new-therapies
#6
David C Klonoff, G Alexander Fleming, Douglas B Muchmore, Brian M Frier
Hypoglycemia complicating diabetes therapy is well recognized to be an ever-present threat to patients, their families, providers, payers and regulators. Despite this being widely acknowledged, the regulatory stance on hypoglycemia as an endpoint in clinical trials to support new product registration has not evolved in any meaningful way since the publication of a position paper by an American Diabetes Association (ADA) Workgroup in 2005. As the impact of hypoglycemia on persons affected by diabetes is of major importance when assessing new treatments, the historical position of regulatory agencies on hypoglycemia is reviewed with respect to product approvals...
January 5, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28032668/might-genetics-play-a-role-in-understanding-and-treating-diabetic-polyneuropathy
#7
Vincenza Spallone
Despite the high prevalence and impact on quality of life, costs and survival, there are still unresolved issues regarding diabetic polyneuropathy (DPN): the lack of definite knowledge of its pathogenesis; the limited preventive action of glycaemic control in type 2 diabetes; and the unavailability of effective evidence-based disease-modifying treatment. How can genetics provide the tools to address these gaps? Ziegler et al for the GDS Group explore the novel hypothesis that genetic variability in transketolase (TKT) might contribute to susceptibility to DPN in patients with newly diagnosed type 1 and type 2 diabetes (well characterised for DPN)...
December 29, 2016: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28032465/diurnal-glucose-exposure-profiles-of-patients-treated-with-lixisenatide-before-breakfast-or-the-main-meal-of-the-day-an-analysis-using-continuous-glucose-monitoring
#8
Richard M Bergenstal, Ellie Strock, Roger Mazze, Margaret A Powers, Arlene M Monk, Sara Richter, Elisabeth Souhami, Bo Ahren
BACKGROUND: In the parent study of this analysis, patients with type 2 diabetes received lixisenatide before breakfast or the main meal of the day. This sub-study was designed to examine the effect of lixisenatide administered before breakfast or the main meal of the day on continuously assessed 24-hour patient glucose profiles. METHODS: A subset of patients from the parent study underwent two 14-day periods of continuous glucose monitoring (CGM) at the start and end of the 24-week study...
December 29, 2016: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28032449/occurrence-over-time-and-regression-of-nonalcholic-fatty-liver-disease-in-type-2-diabetes
#9
Carlo Giorda, Gabriele Forlani, Roberta Manti, Natalia Mazzella, Salvatore De Cosmo, Maria Chiara Rossi, Antonio Nicolucci, Giuseppina Russo, Paolo Di Bartolo, Antonio Ceriello, Piero Guida
BACKGROUND: This analysis was aimed to assess the incidence, regression, and correlated factors of nonalcoholic fatty liver disease (NAFLD) in type 2 diabetes, which are poorly known. METHODS: NAFLD (defined as fatty liver index [FLI] score ≥60) in patients with type 2 diabetes and related factors was investigated in a nationwide database containing information from the Italian network of diabetes clinics. A 10% variation of FLI was the cut-off considered in the analyses of a cohort of 5030 patients which was separately conducted for those who developed, maintained or recovered from FLI-assessed NAFLD (FLI-NAFLD) over a 3-year period...
December 29, 2016: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28032446/magnetic-resonance-imaging-of-intra-pancreatic-ductal-nanoparticle-delivery-to-islet-cells
#10
Ping Wang, Alana Ross, Byunghee Yoo, Jingsheng Yang, Christian Farrar, Chongzhao Ran, Pamela Pantazopoulos, Zdravka Medarova, Anna Moore
The absence of reliable drug delivery systems to pancreatic beta-cells hampers efficient treatment of type 1 diabetes. Nanoparticle delivery systems equipped with imaging capabilities could enable selective delivery to pancreatic islet cells. Biodistribution of nanoparticles is defined by several factors including the mode of administration, which determines accumulation in various organs. In this study we tested whether intra-pancreatic ductal injection of magnetic nanoparticles (MN) would result in efficient cellular uptake by pancreatic islet cells...
December 29, 2016: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28029216/safety-and-efficacy-of-non-vitamin-k-antagonist-oral-anticoagulants-versus-warfarin-in-diabetic-patients-with-atrial-fibrillation-a-study-level-meta-analysis-of-phase-iii-randomized-trials
#11
REVIEW
Giuseppe Patti, Giuseppe Di Gioia, Ilaria Cavallari, Antonio Nenna
BACKGROUND: In patients with atrial fibrillation (AF) the safety and efficacy of non-vitamin K antagonist oral anticoagulants (NOACs) vs warfarin according to diabetes mellitus (DM) status is not completely characterized; we performed a meta-analysis to clarify whether in these patients the strategy of oral anticoagulation should be tailored on diabetes status METHODS: In this study-level meta-analysis we included four randomized phase III trials comparing NOACs and warfarin in patients with non-valvular AF; a total of 18,134 patients with DM and 40,454 without DM were overall considered...
December 28, 2016: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28029212/a-new-model-to-estimate-insulin-resistance-via-clinical-parameters-in-adults-with-type-1-diabetes
#12
Xueying Zheng, Bin Huang, Sihui Luo, Daizhi Yang, Wei Bao, Jin Li, Bin Yao, Jianping Weng, Jinhua Yan
AIMS/HYPOTHESIS: Insulin resistance (IR) is a risk factor to assess the development of micro- and macro-vascular complications in type 1 diabetes (T1D). However, diabetes management in adults with T1D is limited by the difficulty of lacking simple and reliable method to estimate IR. The aim of this study was to develop a new model to estimate IR via clinical parameters in adults with T1D. METHODS: A total of 36 adults with adulthood onset T1D (n = 20) or childhood onset T1D (n = 16) were recruited by quota sampling...
December 28, 2016: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28029211/cardiovascular-risk-factors-and-incident-albuminuria-in-screen-detected-type-2-diabetes
#13
D R Webb, F Zaccardi, M J Davies, S J Griffin, N J Wareham, R K Simmons, G E Rutten, A Sandbaek, T Lauritzen, K Borch-Johnsen, K Khunti
BACKGROUND: It is unclear whether cardiovascular risk factor modification influences the development of renal disease in people with type 2 diabetes identified through screening. We determined predictors of albuminuria five years after a diagnosis of screen-detected diabetes within the ADDITION-Europe study, a pragmatic cardiovascular outcome trial of multifactorial cardiovascular risk management. METHODS: In 1,826 participants with newly diagnosed, screen-detected diabetes without albumiuria, we explored associations between risk of new albuminuria (≥2...
December 28, 2016: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/27935651/epidemiology-of-diabetic-kidney-disease-in-adult-patients-with-type-1-diabetes-in-italy-the-amd-annals-initiative
#14
Antonio Pacilli, Francesca Viazzi, Paola Fioretto, Carlo Giorda, Antonio Ceriello, Stefano Genovese, Giuseppina Russo, Pietro Guida, Roberto Pontremoli, Salvatore De Cosmo
BACKGROUND: Patients with type 1 diabetes mellitus are at increased risk of death. This risk appears to be modulated by kidney dysfunction. Aim of this study was to evaluate the prevalence of diabetic kidney disease (DKD), its traits and clinical correlates in a large sample of patients with type 1 diabetes. METHODS: Clinical data of 20,464 patients with type 1 diabetes were extracted from electronic medical records. Estimated glomerular filtration rate (eGFR) and increased urinary albumin excretion were considered...
December 9, 2016: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/27933750/comparing-glucose-and-hemoglobin-a1c-diagnostic-tests-among-a-high-metabolic-risk-hispanic-population
#15
Mónica A Vega-Vázquez, Margarita Ramirez-Vick, Francisco J Muñoz-Torres, Loida A González-Rodríguez, Kaumudi Joshipura
AIMS: Compare HbA1c diagnostic tests for pre-diabetes and diabetes with plasma glucose criteria (PGC), and compare the metabolic profiles of people classified by HbA1c versus by glucose levels. METHODS: Participants were recruited for the San Juan Overweight Adults Longitudinal Study (SOALS). Were primarily Hispanic (98%), without previously diagnosed diabetes, and aged 40-65 years. Participants classified as normal glycemic, pre-diabetes or diabetes based on baseline HbA1c and PGC, were compared with respect to baseline cardiometabolic factors...
December 9, 2016: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/27883367/a-drop-in-the-circulating-concentrations-of-soluble-receptor-for-ages-is-associated-with-seroconversion-to-autoantibody-positivity-but-not-with-subsequent-progression-to-clinical-disease-in-children-en-route-to-type-1-diabetes
#16
K M Salonen, S J Ryhänen, J M Forbes, T Härkönen, J Ilonen, O Simell, R Veijola, P-H Groop, M Knip
BACKGROUND: Advanced glycation end products (AGEs) and their interaction with the receptor for advanced glycation end products (RAGE) have been studied for their role in the pathogenesis and complications of type 1 diabetes. Decreased concentrations of soluble RAGE (sRAGE) have been reported in acute autoimmune inflammation. We set out to analyze the changes in (sRAGE) concentration during preclinical diabetes in children seroconverting to islet autoantibody positivity. METHODS: We measured serum concentrations of sRAGE in 168 children who progressed to clinical disease and 43 children who turned positive for at least two diabetes-associated autoantibodies but remained non-diabetic...
November 24, 2016: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/27883358/negative-pressure-wound-therapy-inhibit-inflammation-by-up-regulating-atf-3-and-down-regulating-nuclear-factor-%C3%AE%C2%BAb-in-diabetic-patients-with-foot-ulcerations
#17
T Wang, R He, J Zhao, J C Mei, M Z Shao, Y Pan, J Zhang, H S Wu, M Yu, W C Yan, L M Liu, F Liu, W P Jia
BACKGROUND: Negative pressure wound therapy (NPWT) was one of the most important treatments of diabetic foot, but the underlying mechanisms still remain elusive. This study aimed to evaluate the inflammatory signals involved in the effects of NPWT on diabetic foot ulcers. METHODS: We enrolled 22 patients with diabetic foot ulceration, eleven treated with NPWT and others treated with traditional debridement. All the patients were treated and observed for 1 week...
November 24, 2016: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/27862917/assessing-variation-across-8-established-east-asian-loci-for-type-2-diabetes-mellitus-in-american-indians-suggestive-evidence-for-new-sex-specific-diabetes-signals-in-glis3-and-zfand3
#18
Yunhua L Muller, Paolo Piaggi, Peng Chen, Gregory Wiessner, Chidinma Okani, Sayuko Kobes, William C Knowler, Clifton Bogardus, Robert L Hanson, Leslie J Baier
BACKGROUND: Eight new loci for type 2 diabetes mellitus (T2DM) were identified in an East Asian genome-wide association study meta-analysis. We assess tag SNPs across these loci for associations with T2DM in American Indians. METHODS: A total of 435 SNPs that tag (R(2)  ≥ .85) common variation across the 8 loci were analyzed for association with T2DM (n = 7710), early onset T2DM (n = 1060), body mass index (n = 6839), insulin sensitivity (n = 555), and insulin secretion (n = 298)...
November 8, 2016: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/27862843/elevated-circulating-neuregulin4-level-in-patients-with-diabetes
#19
Lu-Lu Chen, Miao-Miao Peng, Jiao-Yue Zhang, Xiang Hu, Jie Min, Qiu-Lan Huang, Li-Min Wan
BACKGROUND: Neuregulin4 (Nrg4) is a novel adipokine expressed in adipose tissues, enriched in brown adipose tissue, and able to improve whole-body metabolism in rodent, thus having the potential to treat obesity-associated disorders such as diabetes. However, the association between serum Nrg4 levels and diabetes risk in human remains unclear. This study was designed to examine circulating Nrg4 levels in subjects with different glucose tolerance status. METHODS: Age-, sex-, and body mass index-matched subjects (n = 310: 83 normal glucose tolerance [NGT], 129 prediabetes, and 96 diabetes) from the Risk Evaluation of Cancers in Chinese Diabetic Individuals: A Longitudinal study (Reaction study) were included...
November 8, 2016: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/27860198/diabetes-mellitus-and-long-term-mortality-of-ovarian-cancer-patients-a-systematic-review-and-meta-analysis-of-12-cohort-studies
#20
Dongyu Zhang, Yuan Zhao, Tengteng Wang, Yuzhi Xi, Nan Li, Hongtai Huang
AIM: Ovarian cancer (OC) is the sixth most common cancer among women, and its prognosis is not favorable. Diabetes mellitus (DM) is hypothesized to be associated with a higher mortality in ovarian cancer patients, but evidence is inconsistent. Thus, we aim to investigate if DM is associated with the long-term all-cause and long-term cancer-specific mortality in ovarian cancer patients by synthesizing available epidemiologic evidences. METHODS: We used 4 electronic databases (PubMed, EMBASE, Web of Science, and Scopus) to search for eligible articles...
November 8, 2016: Diabetes/metabolism Research and Reviews
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