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Diabetes/metabolism Research and Reviews

Nadeeja N Wijayatunga, Valerie G Sams, John A Dawson, Matthew L Mancini, Gregory J Mancini, Naima Moustaid-Moussa
AIM: Bariatric surgery induces significant weight loss, increases insulin sensitivity and reduces mortality, but the underlying mechanisms are not clear. It was hypothesized that Roux-en-Y gastric bypass (RYGB) surgery improves metabolic profile along with weight loss. The objective of this study was to evaluate changes in serum metabolites and fatty acids (FA) at two weeks and six months after RYGB. MATERIALS AND METHODS: Serum samples were collected pre-surgery, at 2 weeks and 6 months post-surgery from twenty patients undergoing RYGB surgery...
July 13, 2018: Diabetes/metabolism Research and Reviews
Jing Wang, Yongkai Yu, Xiaowen Li, Dong Li, Chengwei Xu, Jing Yuan, Sheng Wei, Xiulou Li, Kun Yang, Dan Zheng, Yuhan Tang, Handong Yang, Tangchun Wu, Meian He
BACKGROUND: Epidemiological studies suggest that elevated serum uric acid (SUA) is associated with heightened incident kidney disease in both the general population and the type 2 diabetes (T2D) cases, although the results were not entirely consistent. METHODS: We investigated prospective association between SUA levels and estimated glomerular filtration (eGFR) decline risk (eGFR < 60 ml min-1 1.73 m-2 ) among 3,123 type 2 diabetes in the Dongfeng-Tongji cohort, further examine this association with a meta-analysis...
July 13, 2018: Diabetes/metabolism Research and Reviews
Hassan Fadavi, Mitra Tavakoli, Philip Foden, Maryam Ferdousi, Ioannis Petropoulos, Maria Jeziorska, Nishi Chaturvedi, Andrew J M Boulton, Rayaz A Malik, Caroline A Abbott
BACKGROUND: Low foot ulcer risk in South Asian, compared with European, people with type 2 diabetes in the UK has been attributed to their lower levels of neuropathy. We have undertaken a detailed study of corneal nerve morphology and neuropathy risk factors, to establish the basis of preserved small nerve fibre function in South Asians versus Europeans. METHODS: In a cross-sectional, population-based study, age- and sex-matched South Asians (n=77) and Europeans (n=78) with type 2 diabetes underwent neuropathy assessment using corneal confocal microscopy, symptoms, signs, quantitative sensory testing, electrophysiology and autonomic function testing...
July 4, 2018: Diabetes/metabolism Research and Reviews
Agata Chobot, Katarzyna Górowska-Kowolik, Magdalena Sokołowska, Przemysława Jarosz-Chobot
Diabetes (DM) as well as obesity, due to their increasing incidence, were recognized as epidemic by the World Health Organization (WHO). Obesity is not only involved in the etiopathogenesis of the most common worldwide type of DM - type 2 diabetes (T2D), but also in the development of its complications. There is also increasing scientific evidence regarding the role of obesity and overweight in type 1 diabetes (T1D). Weight gain may be considered as a complication of insulin treatment, but also reveals significant pathophysiological impact on various stages of the disease...
June 21, 2018: Diabetes/metabolism Research and Reviews
Peilin Zheng, Zhixia Li, Zhiguang Zhou
Type 1 diabetes (T1D) is an autoimmune disease, which is characterized by the destruction of islet β cells in the pancreas triggered by genetic and environmental factors. In past decades, extensive familial and genome-wide association studies have revealed more than 50 risk loci in the genome. However, genetic susceptibility cannot explain the increased incidence of T1D worldwide, which is very likely attributed by the growing impact of environmental factors, especially gut microbiome. Recently, the role of gut microbiome in the pathogenesis of T1D have been uncovered by the increasing evidence from both human subjects and animal models, strongly indicating that gut microbiome might be a pivotal hub of T1D-triggering factors, especially environmental factors...
June 21, 2018: Diabetes/metabolism Research and Reviews
Lenore Arab, Satvinder K Dhaliwal, Carly J Martin, Alena D Larios, Nicholas J Jackson, David Elashoff
BACKGROUND: Dietary interventions and cohort studies relating tree nut consumption to blood glucose levels suggest a possible effect of walnuts. OBJECTIVE: To examine the associations between walnut consumption and diabetes risk using data from the National Health and Nutrition Examination Survey (NHANES). METHODS: NHANES survey data on adults conducting 24 hour dietary recall was pooled across the years 1999 through 2014. Diabetes status or risk was based on self-report, medication use, fasting plasma (FPG) glucose levels and hemoglobin A1c (HbA1c) levels...
June 21, 2018: Diabetes/metabolism Research and Reviews
B Vincenzi, L D'Onofrio
No abstract text is available yet for this article.
June 21, 2018: Diabetes/metabolism Research and Reviews
Perdana Samekto Tyasnugroho Suyoto
Meta-analysis was conducted to clarify the effect of low carbohydrate diet (LCD) on renal function in patients with type 2 diabetes mellitus (T2DM). An extensive literature search was conducted on scientific databases including PubMed, Scopus, and Cochrane Library until September 2017. Only controlled trials on human subjects written in English were included in this meta-analysis. Several markers of renal function were compared between subjects who adopted a LCD or control diet, including estimated glomerular filtration rate (eGFR), creatinine clearance, urinary albumin, serum creatinine, and serum uric acid...
June 14, 2018: Diabetes/metabolism Research and Reviews
Rachel Natovich, Noa Gayus, Michal Azmon, Hila Michal, Omri Gury Twito, Tomer Yair, Romi Noy Achiron, Neta Kraviz, Nadia Mordenfeld, Tali Cukierman-Yaffe
BACKGROUND: Successful aging with diabetes is challenged by co-morbidities which may present barriers to self-care. Currently, measurement of physical and cognitive status is not part of routine care of the older person with diabetes and these are not taken into account when devising the treatment plan. OBJECTIVE: To describe a novel approach that integrates cognitive and physical assessment into the routine evaluation of the older person with diabetes & the tailor-made treatment plan devised accordingly...
June 13, 2018: Diabetes/metabolism Research and Reviews
Sharon Li Ting Pek, Anton Kui Sing Cheng, Michelle Xueqin Lin, Moh Sim Wong, Eric Chan Zit Liang, Angela Mei Chung Moh, Chee Fang Sum, Su Chi Lim, Subramaniam Tavintharan
OBJECTIVE: Obesity confers substantial excess risk for morbidity and mortality, especially for Type 2 diabetes (T2D). Leucine-Rich-α2-Glycoprotein 1 (LRG1), a novel pro-inflammatory factor, was recently reported to be higher in patients with T2D with complications of peripheral arterial disease. Association of LRG1, obesity and weight loss is unknown. We examined whether plasma LRG1 is associated with obesity in health screening participants and if it predicts future weight loss in morbidly obese patients after metabolic/bariatric surgery...
June 8, 2018: Diabetes/metabolism Research and Reviews
Adeniyi A Borire, Tushar Issar, Natalie C Kwai, Leo H Visser, Neil G Simon, Ann M Poynten, Matthew C Kiernan, Arun V Krishnan
BACKGROUND: Clinical and experimental studies in patients with type 1 and type 2 diabetes have demonstrated changes in ion channel function and nerve structure. In this study, we investigated the relationship between axonal dysfunction and morphological change in diabetic polyneuropathy by using neuromuscular ultrasound and nerve excitability techniques. We also explored possible differences in this relationship between type 1 and type 2 diabetes. METHODS: Nerve ultrasound and corresponding motor excitability studies were undertaken in 110 diabetes patients (50 type 1; 60 type 2) and 60 age-matched controls (30 for each group)...
June 1, 2018: Diabetes/metabolism Research and Reviews
Amit Akirov, Talia Diker-Cohen, Hiba Masri-Iraqi, Hadar Duskin-Bitan, Ilan Shimon, Alexander Gorshtein
OBJECTIVE: To examine the prognostic implications of diabetes mellitus (DM) and the importance of glycemic control during hospitalization for infectious diseases. METHODS: Historical prospectively collected data of patients hospitalized between 2011 and 2013. Infection-related hospitalizations were classified according to site of infection. Median follow-up was 4.5 years. Outcome measures included in-hospital and end-of-follow-up mortality. RESULTS: The cohort included 8051 patients (50% female, mean age ± SD, 68 ± 20 years) with a primary diagnosis of an infectious disease...
May 17, 2018: Diabetes/metabolism Research and Reviews
Ussama M Abdel-Motal, Akila G, Essam M Abdelalim, Chinnaiyan Ponnuraja, Khadija Iken, Mohamed Jahromi, George Priya Doss, Rajaa El Bekay, Hatem Zayed
The aim of this study was to conduct a systematic review and meta-analysis and determine the prevalence of diabetic nephropathy (DN) among Arab patients with T1D. A systematic literature search was conducted using 4 different literature databases (PubMed, ScienceDirect, Web of Science, and Embase) to capture all relevant data about Arab patients with T1D that had DN. Meta-analysis and systematic review were performed using the random effect model, and the heterogeneity of the studies was assessed using the Q-test, I2, and Tau-squared statistics...
May 17, 2018: Diabetes/metabolism Research and Reviews
A Lautenbach, M Wernecke, N Riedel, J Veigel, J Yamamura, S Keller, R Jung, P Busch, O Mann, F K Knop, J J Holst, J J Meier, J Aberle
BACKGROUND: Obesity has been shown to trigger adaptive increases in pancreas parenchymal and fat volume. Consecutively, pancreatic steatosis may lead to beta-cell dysfunction. However, it is not known whether the pancreatic tissue components decrease with weight loss and pancreatic steatosis is reversible following Roux-en-Y gastric bypass (RYGB). Therefore, the objective of the study was to investigate the effects of RYGB-induced weight loss on pancreatic volume and glucose homeostasis...
May 16, 2018: Diabetes/metabolism Research and Reviews
Sho-Ichi Yamagishi
No abstract text is available yet for this article.
May 15, 2018: Diabetes/metabolism Research and Reviews
Kanako Shimura, Junnosuke Miura, Manabu Kawamoto, Yasushi Kawaguchi, Hisashi Yamanaka, Yasuko Uchigata
BACKGROUND: Clusters of autoimmune diseases (ADs) are present in some people with type 1 diabetes. This clustering suggests the existence of common genetic backgrounds for abnormal autoimmunity in these individuals. However, the genetic differences between type 1 diabetes patients with and without other ADs are not well known. METHODS: To investigate the clinical background and genetic differences between type 1 diabetes patients with and without other ADs, single nucleotide polymorphisms (SNPs) in the CTLA4, SUMO4, PTPN22, IRF5, STAT4, and BLK genes were analysed by using either a TaqMan assay or direct sequencing...
May 15, 2018: Diabetes/metabolism Research and Reviews
Mahmoud Ibrahim, Jaakko Tuomilehto, Pablo Aschner, Lucille Beseler, Avivit Cahn, Robert H Eckel, Amy Hess Fischl, George Guthrie, James O Hill, Mick Kumwenda, R David Leslie, Darin E Olson, Paolo Pozzilli, Sandra L Weber, Guillermo E Umpierrez
Primary prevention of type 2 diabetes (T2D) should be achievable through the implementation of early and sustainable measures. Several randomized control studies that found success in preventing the progression to T2D in high-risk populations have identified early and intensive intervention based on an individualized prevention model as the key factor for participant benefit. The global prevalence of both overweight and obesity has now been widely recognized as the major epidemic of the 21st century. Obesity is a major risk factor for the progression from normal glucose tolerance to prediabetes and then to T2D...
May 14, 2018: Diabetes/metabolism Research and Reviews
Philippe Thuillier, Emmanuel Sonnet, Zarrin Alavi, Nathalie Roudaut, Emmanuel Nowak, Angélina Dion, Véronique Kerlan
BACKGROUND: The objective was to compare glycemic control between preprandial and postprandial bolus administration (15 min before [PRE] or immediately after the meal [POST]) in patients with type 1 diabetes using insulin pump and real-time continuous glucose monitoring. METHODS: Between September 2015 and February 2016, a single-centre, open randomized, 2-way crossover study of patients on bolus insulin aspart administration was conducted during two 14-day periods and according to 2 administration regimen schedules (PRE/POST or POST/PRE)...
May 10, 2018: Diabetes/metabolism Research and Reviews
Hong Zhou, Yonghong Sun, Lihui Zhang, Wenyuan Kang, Na Li, Yongjun Li
AIMS: To understand the roles of the RhoA/ROCK and mitogen-activated protein kinase (MAPK) pathways in high glucose (HG)-induced apoptosis and oxidative stress in cardiomyocytes. MATERIALS AND METHODS: Neonatal rat cardiomyocytes were cultured in Dulbecco's modified Eagle's medium, supplemented with 5.5 or 30 mmol/L D-glucose, in the presence or absence of fasudil (50 or 100 μM), SB203580, SP600125, or PD98059 (10 μM, respectively). The percentage of early apoptotic cardiomyocytes was evaluated using flow cytometry...
May 9, 2018: Diabetes/metabolism Research and Reviews
Barbara Bohn, Arthur Grünerbel, Marcus Altmeier, Carsten Giesche, Martin Pfeifer, Christian Wagner, Nikolai Heise, Frank Best, Peter Fasching, Reinhard W Holl
AIMS: The diabetic foot syndrome (DFS) is a serious complication in patients with diabetes increasing the risk for minor/major amputations. This analysis aimed to examine differences in diabetes patients with or without DFS stratified by type 1 (T1D) or type 2 diabetes (T2D). MATERIAL AND METHODS: Adult patients (≥20y of age) with diabetes from the German/Austrian diabetes patients follow-up registry (DPV) were included. The cross-sectional study comprised 45 722 subjects with T1D (nDFS  = 2966) and 313 264 with T2D (nDFS  = 30 904)...
May 3, 2018: Diabetes/metabolism Research and Reviews
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