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Diabetes/metabolism Research and Reviews

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https://www.readbyqxmd.com/read/28925010/temporal-trends-in-quality-of-primary-care-for-patients-with-type-2-diabetes-mellitus-a-population-based-retrospective-cohort-study-after-implementation-of-a-quality-improvement-initiative
#1
Carlos K H Wong, Colman S C Fung, Esther Y T Yu, Eric Y F Wan, Anca K C Chan, Cindy L K Lam
BACKGROUND: This study examined whether temporal trends exist in treatment of patients with type 2 diabetes (T2D) and quality of diabetes care after implementation of quality improvement initiative in primary care setting. METHODS: We conducted a population-based retrospective cohort study of 202,284 patients with T2D who were routinely managed in primary care clinics. We examined the change over time and the variability between clinics in quality-of-care from Hospital Authority administrative data over a five-year period (2009-2013), and used multilevel logistic regression to adjust for patient and clinic characteristics...
September 19, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28921837/coronary-artery-bypass-grafting-versus-percutaneous-coronary-intervention-in-patients-with-non-insulin-treated-type-2-diabetes-mellitus-a-meta-analysis-of-randomized-controlled-trials
#2
Yushu Wang, Meiqin Wen, Junteng Zhou, Yucheng Chen, Qing Zhang
INTRODUCTION: The outcomes and prognosis of revascularization by either coronary artery bypass grafting (CABG) surgery or percutaneous coronary intervention (PCI) in patients with non-insulin treated type 2 diabetes mellitus (NITDM) have not yet been well established. METHODS: Randomized controlled trials (RCTs) were identified by searching Pubmed, EMBASE and Cochrane library from inception until May 2016. Heterogeneity was evaluated and the pooled hazard ratio (HR) was calculated using a fixed-effect model...
September 15, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28921828/hdl-c-apoa-i-a-multi-vessel-cardiometabolic-risk-marker-in-women-with-t2dm
#3
Michel P Hermans, Paul Valensi, Sylvie A Ahn, Michel F Rousseau
AIMS: Although women have higher HDL-C than men, their HDL particles are also prone to become small, dense and dysfunctional in case of T2DM. To assess the vascular risk related to HDLs of different sizes/densities without direct measurement, we adjusted HDL-C to its main apolipoprotein (apoA-I), as [HDL-C/apoA-I]. This ratio estimates HDLs size and provides indices as to their number, cholesterol load, and density. METHODS: We stratified 280 Caucasian T2DM women according to [HDL-C/apoA-I] quartiles (Q), to determine how it segregates cardiometabolic risk, β-cell function, glycemic control, and vascular complications...
September 15, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28886616/association-of-change-in-waist-circumference-and-dyslipidemia-risk-the-rural-chinese-cohort-study
#4
Junmei Zhou, Yongcheng Ren, Chongjian Wang, Linlin Li, Lu Zhang, Bingyuan Wang, Yang Zhao, Chengyi Han, Hongyan Zhang, Xiangyu Yang, Xinping Luo, Chao Pang, Lei Yin, Tianping Feng, Jingzhi Zhao, Dongsheng Hu, Ming Zhang
OBJECTIVE: To investigate the association of change in waist circumference (WC) and incidence of dyslipidemia in a cohort study of a rural Chinese population. METHODS: Change in WC (ΔWC) was defined as the value at follow-up minus the corresponding value at baseline. Risk of dyslipidemia associated with ΔWC was assessed by odds ratios (ORs) and 95% confidence intervals (CIs) in a logistic regression model, and the ORs were transformed to RRs. RESULTS: Among 7,691 participants without dyslipidemia at baseline, 3,213 (41...
September 8, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28865238/association-between-insulin-induced-weight-change-and-cvd-mortality-evidence-from-a-historical-cohort-study-of-18-814-patients-in-uk-primary-care
#5
U Anyanwagu, J Mamza, R Donnelly, I Idris
BACKGROUND: This study explore the association of insulin-induced weight (wt) gain on CV outcomes and mortality amongst patients with T2D following insulin initiation using real-world data METHODS: A historical cohort study was performed in 18,814 adults with insulin-treated T2D derived from the UK Health Improvement Network (THIN) database. Based on the average weight change of 5kg, one year post-insulin initiation, patients were grouped into 5 categories (>5kg wt loss; 1.0-5.0kg wt loss; no wt change; 1...
September 2, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28843039/tnf-tnf-inducers-and-tnfr2-agonists-a-new-path-to-type-1-diabetes-treatment
#6
REVIEW
Denise L Faustman
BACKGROUND: In the past decade, interest in the century-old tuberculosis vaccine, bacillus Calmette-Guerin (BCG), has been revived for potential new therapeutic uses in type 1 diabetes and other forms of autoimmunity. METHODS: Diverse clinical trials are now proving the value of BCG in prevention and treatment of type 1 diabetes, in the treatment of new onset multiple sclerosis and other immune conditions. BCG contains the avirulent tuberculosis strain Mycobacterium bovis, a vaccine originally developed for tuberculosis prevention...
August 26, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28843034/changing-psychosocial-determinants-of-physical-activity-and-diet-in-women-with-a-history-of-gestational-diabetes-mellitus
#7
Judith G M Jelsma, Mireille N M van Poppel, Ben J Smith, Nancy Cinnadaio, Adrian Bauman, Linda Tapsell, N Wah Cheung, Hidde P van der Ploeg
AIM: To investigate how a behavioural lifestyle intervention influences psychosocial determinants of physical activity and dietary behaviours in a population at risk of type 2 diabetes (T2DM). METHODS: 59 women with a body mass index of ≥25 kg/m(2) and a history of gestational diabetes mellitus (GDM) participated in a randomized controlled study. The intervention group (n=29) received two face-to-face and five telephone lifestyle-counselling sessions with a health professional...
August 26, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28843031/diabetes-primary-prevention-program-new-insights-from-data-analysis-of-recruitment-period
#8
Juan J Gagliardino, Jorge F Elgart, Marcelo Bourgeois, Graciela Etchegoyen, Gabriel Fantuzzi, Matías Ré, Juan P Ricart, Silvia García, Cecilia Giampieri, Lorena González, Florencia Suárez-Crivaro, Peter Kronsbein, Julieta M Angelini, Camilo Martínez, Jorge Martínez, Alberto Ricart, Eduardo Spinedi
OBJECTIVES: Primary Prevention of Diabetes Program in Buenos Aires Province (PPDBA) evaluates the effectiveness of adopting healthy lifestyle to prevent type 2 diabetes (T2D) in people at high risk of developing it. We aimed to present preliminary data analysis of FINDRISC and laboratory measurements taken during recruitment of people for the PPDBA in the cities of La Plata, Berisso and Ensenada, Argentina. METHODS: People were recruited through: Population approach (house to house survey by FINDRISC in randomized areas) and opportunistic approach (FINDRISC completed by participants during consultations for non-related pre-diabetes/diabetes symptoms in public and private primary care centers of cities involved)...
August 26, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28840639/use-of-oral-antidiabetic-drugs-in-the-treatment-of-maturity-onset-diabetes-of-the-young-mody-a-minireview
#9
REVIEW
Ludmila Brunerova, Dario Rahelić, Antonio Ceriello, Jan Broz
BACKGROUND: MODY (Maturity-onset diabetes of the young) is a genetically linked group of clinically heterogeneous subtypes of diabetes. Roughly 5% of people with diabetes mellitus diagnosed prior to age 45 have MODY diabetes, the majority of whom have been erroneously diagnosed as patients with either Type 1 or Type 2 diabetes and, as a result, have been improperly treated. Genetic identification of MODY diabetes and its subtypes allows proper treatment and enables clinicians to switch many patients to oral antidiabetic agents, mainly sulphonylureas...
August 24, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28834086/single-and-combined-effects-of-inflammatory-markers-on-10-year-diabetes-incidence-the-mediating-role-of-adiposity-results-from-the-attica-cohort-study
#10
Efi Koloverou, Demosthenes B Panagiotakos, Ekavi N Georgousopoulou, Christina Chrysohoou, Dimitrios Tousoulis, Christodoulos Stefanadis, Christos Pitsavos
BACKGROUND: the role of inflammation in diabetes development is not fully elucidated. The aim of this work was to investigate the independent effect of individual inflammatory markers and combinations of them on diabetes incidence and the potential mediating role of obesity. METHODS: in 2001-02, a random sample of 1514 men (18-87 years old) and 1528 women (18-89 years old) was selected to participate in the ATTICA study, where Athens is a major metropolis. IL-6, CRP, TNF-a, SAA, fibrinogen and homocysteine were measured...
August 23, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28834008/risk-of-type-2-diabetes-in-patients-with-insomnia-a-population-based-historical-cohort-study
#11
Chia-Ling Lin, Wu-Chien Chien, Chi-Hsiang Chung, Fei-Ling Wu
OBJECTIVE: We investigated the risk of type 2 diabetes mellitus (T2DM) in patients with and without insomnia. METHODS: In this historical cohort study, we performed a secondary analysis of data from 2001 to 2010, which was obtained from Taiwan's National Health Insurance Database. We developed a Cox proportional hazard regression model to estimate the effects of insomnia on T2DM risk. Kaplan-Meier survival analysis was applied to compare the differences in the cumulative incidence of T2DM between the groups with and without insomnia...
August 18, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28817237/dysregulation-of-wound-healing-mechanisms-in-diabetes-and-the-importance-of-negative-pressure-wound-therapy-npwt
#12
Mogher Khamaisi, Sarit Balanson
Diabetes is a serious disease with severe side effects and comorbidities. Diabetic foot with its chronic non-healing ulcers, or diabetic food ulcers (DFU) as they are commonly called, can be devastating, even leading to amputation. Many therapies exist to assist and improve wound healing. One exciting discovery is the use of negative pressure wound therapy (NPWT) as an adjunct to standard treatment. Few studies have substantively explored the molecular mechanisms of NPWT and why we see improved wound healing, a concept that demands more research...
August 17, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28817230/recent-findings-on-fulminant-type-1-diabetes
#13
REVIEW
Lan Liu, Ling Zeng, Dan Sang, Zeyuan Lu, Jie Shen
Fulminant type 1 diabetes (fT1D) is a new subtype of type 1 diabetes proposed by Imagawa in 2000. It is a clinical syndrome characterized by a markedly rapid and almost complete destruction of pancreatic β cells. Metabolic derangement is more severe in this subtype than in autoimmune type 1 diabetes. The incidence of fT1D is associated with HLA DRB1*04:05DQB1*04:01, both innate and acquired immune disorders might contribute to the development of fT1D. The presence of specific innate immune responses to enterovirus infection connected with enhanced adoptive immune pathways responsible for aggressive β cell toxicity in fT1D...
August 17, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28806491/the-association-between-dysregulated-adipocytokines-in-early-pregnancy-and-development-of-gestational-diabetes
#14
Sally K Abell, Soulmaz Shorakae, Cheryce L Harrison, Danielle Hiam, Alba Moreno-Asso, Nigel K Stepto, Barbora De Courten, Helena J Teede
BACKGROUND: To investigate the association of adipocytokines and other inflammatory markers with development of GDM. METHODS: Serum adipocytokines and inflammatory markers were studied at 12-15 weeks gestation using biobanked control samples from a randomised trial. Study participants were identified as high risk for GDM using a validated clinical risk prediction tool. Markers were tested using commercial ELISA kits for high molecular weight (HMW) adiponectin, interleukin-6 (IL-6), plasminogen activator inhibitor-1, visfatin, omentin-1, sex-hormone binding globulin, monocyte chemoattractant protein and asymmetrical dimethylarginine...
August 14, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28806487/gut-microbiome-response-to-short-term-dietary-interventions-in-reactive-hypoglycemia-subjects
#15
Sara Quercia, Silvia Turroni, Jessica Fiori, Matteo Soverini, Simone Rampelli, Elena Biagi, Andrea Castagnetti, Clarissa Consolandi, Marco Severgnini, Mario Pianesi, Francesco Fallucca, Paolo Pozzilli, Patrizia Brigidi, Marco Candela
BACKGROUND: Reactive hypoglycemia (RH) is a metabolic disorder that provokes severe hypoglycemic episodes after meal. Over recent years, the gut microbiota (GM) has been recognized as potential target for the control of metabolic diseases, and the possibility to correct GM dysbioses through diet, favoring the recovery of metabolic homeostasis, has been considered. METHODS: We investigate the impact of two short-term (3-day) nutritional interventions, based on the macrobiotic Ma-Pi 2 diet and a control Mediterranean diet, on the structure and functionality of the GM in 12 patients affected by RH...
August 14, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28755385/building-and-validating-a-prediction-model-for-pediatric-type-1-diabetes-risk-using-next-generation-targeted-sequencing-of-class-ii-hla-genes
#16
Lue Ping Zhao, Annelie Carlsson, Helena Elding Larsson, Gun Forsander, Sten A Ivarsson, Ingrid Kockum, Johnny Ludvigsson, Claude Marcus, Martina Persson, Ulf Samuelsson, Eva Örtqvist, Chul-Woo Pyo, Hamid Bolouri, Michael Zhao, Wyatt C Nelson, Daniel E Geraghty, Åke Lernmark
AIM: It is of interest to predict possible lifetime risk of type diabetes (T1D) in young children for recruiting high-risk subjects into longitudinal studies of effective prevention strategies. METHODS: Utilizing a case-control study in Sweden, we applied a recently developed next generation targeted sequencing (NGTS) technology to genotype class II genes, and applied an object-oriented regression (OOR) to build and validate a prediction model for T1D. RESULTS: In the training set, estimated risk scores were significantly different between patients and controls (P=8...
July 29, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28753251/liraglutide-mitigates-tnf-%C3%AE-induced-pro-atherogenic-changes-and-microvesicle-release-in-huvec-from-diabetic-women
#17
Pamela Di Tomo, Paola Lanuti, Natalia Di Pietro, Maria Pompea Antonia Baldassarre, Marco Marchisio, Assunta Pandolfi, Agostino Consoli, Gloria Formoso
BACKGROUND: To evaluate whether exposure to GLP-1 receptor agonist Liraglutide could modulate pro-atherogenic alterations previously observed in endothelial cells obtained by women affected by gestational diabetes (GD), thus exposed in vivo to hyperglycemia, oxidative stress, and inflammation and to evaluate endothelial microvesicle (EMV) release, a new reliable biomarker of vascular stress/damage. METHODS: We studied Liraglutide effects and its plausible molecular mechanisms on monocyte cell adhesion and adhesion molecule expression and membrane exposure in control (C-) human umbilical vein endothelial cells (HUVEC) as well as in HUVEC of women affected by GD exposed in vitro to TNF-α...
July 28, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28736981/ketoacidosis-and-sglt2-inhibitor-treatment-analysis-of-faers-data
#18
Jenny E Blau, Sri Harsha Tella, Simeon I Taylor, Kristina I Rother
BACKGROUND: Regulatory agencies have concluded that sodium glucose cotransporter 2 (SGLT2) inhibitors lead to ketoacidosis, but published literature on this point remains controversial. METHODS: We searched the FDA Adverse Event Reporting System (FAERS) for reports of acidosis in patients treated with canagliflozin, dapagliflozin, or empagliflozin (from the date of each drug's FDA approval until May 15, 2015). We compared the number of SGLT2 inhibitor-related reports to reports of acidosis in patients treated with the two most commonly used DPP4 inhibitors: sitagliptin and saxagliptin...
July 24, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28731619/new-onset-diabetes-after-kidney-transplantation-is-associated-with-increased-mortality-a-retrospective-cohort-study
#19
L Cooper, N Oz, G Fishman, T Shohat, R Rahamimov, E Mor, H Green, A Grossman
OBJECTIVE: Clinical outcomes in individuals with new onset diabetes after transplantation (NODAT) and the optimal treatment for this complication are poorly characterized. This study was intended to better define these issues. METHODS: Patients who underwent kidney transplantation and did not have diabetes prior to transplantation were included in the study and clinical outcomes were compared between those who developed NODAT and those who did not. In those who developed NODAT, oral therapy was compared with insulin based therapy...
July 21, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28731290/autoantibodies-against-pfdn2-are-associated-with-an-increased-risk-of-type-2-diabetes-a-case-control-study
#20
Douglas C Chang, Paolo Piaggi, Robert L Hanson, William C Knowler, Clifton Bogardus, Jonathan Krakoff
BACKGROUND: The adaptive immune system is involved in type 2 diabetes mellitus (T2DM), indicating the presence of unidentified autoantibodies that might be useful biomarkers for emerging immunomodulatory therapy. A prior microarray study with a small number of participants suggested the association of novel autoantibodies with T2DM in Southwest American Indians (SAIs). We therefore sought to determine whether antibodies against 14 target proteins are associated with T2DM in a large case-control study...
July 21, 2017: Diabetes/metabolism Research and Reviews
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