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Diabetes/metabolism Research and Reviews

Amit Akirov, Talia Diker-Cohen, Hiba Masri-Iraqi, Hadar Duskin-Bitan, Ilan Shimon, Alexander Gorshtein
OBJECTIVE: Examine the prognostic implications of diabetes mellitus (DM) and the importance of glycemic control during hospitalization for infectious diseases. METHODS: Historical prospectively collected data of patients hospitalized between 2011-2013.Infection-related hospitalizations were classified according to site of infection. Median follow-up was 4.5 years. Outcome measures included in-hospital and end-of-follow-up mortality. RESULTS: The cohort included 8,051 patients (50% female, mean age ± SD, 68±20 years) with a primary diagnosis of an infectious disease...
May 17, 2018: Diabetes/metabolism Research and Reviews
Ussama M Abdel-Motal, Akila G, Essam M Abdelalim, Chinnaiyan Ponnuraja C, Khadija Iken, Mohamed Jahromi, George Priya Doss C, Rajaa El Bekay, Hatem Zayed
AIMS: To conduct a systematic review and meta-analysis and to determine the prevalence of diabetic nephropathy (DN) among Arab patients with type 1 diabetes (T1D) METHODS: Four different literature databases were used (PubMed, ScienceDirect, Web of Science, and EMBASE) to capture all relevant data about Arab patients with T1D and nephropathy. Meta-analysis and systematic review were performed using the random effect model, and the heterogeneity of the studies was assessed using the Q-test, I2 index and Tau-squared statistics...
May 17, 2018: Diabetes/metabolism Research and Reviews
A Lautenbach, M Wernecke, N Riedel, J Veigel, J Yamamura, S Keller, R Jung, P Busch, O Mann, F K Knop, J J Holst, J J Meier, J Aberle
AIMS: Obesity has been shown to trigger adaptive increases in pancreas parenchymal and fat volume. Consecutively, pancreatic steatosis may lead to beta-cell dysfunction. However, it is not known, whether the pancreatic tissue components decrease with weight loss and pancreatic steatosis is reversible following RYGB. Therefore, the objective of the study was to investigate the effects of RYGB-induced weight loss on pancreatic volume and glucose homeostasis. MATERIALS AND METHODS: 11 patients were recruited in the Obesity Centre of the University Medical Centre Hamburg-Eppendorf...
May 16, 2018: Diabetes/metabolism Research and Reviews
Sho-Ichi Yamagishi
No abstract text is available yet for this article.
May 15, 2018: Diabetes/metabolism Research and Reviews
Kanako Shimura, Junnosuke Miura, Manabu Kawamoto, Yasushi Kawaguchi, Hisashi Yamanaka, Yasuko Uchigata
BACKGROUND: Clusters of autoimmune diseases (ADs) are present in some people with type 1 diabetes. This clustering suggests the existence of common genetic backgrounds for abnormal autoimmunity in these individuals. However, the genetic differences between type 1 diabetes patients with and without other ADs are not well known. METHODS: To investigate the clinical background and genetic differences between type 1 diabetes patients with and without other ADs, SNPs in the CTLA4, SUMO4, PTPN22, IRF5, STAT4 and BLK genes were analyzed using either a TaqMan assay or direct sequencing...
May 15, 2018: Diabetes/metabolism Research and Reviews
Mahmoud Ibrahim, Jaakko Tuomilehto, Pablo Aschner, Lucille Beseler, Avivit Cahn, Robert H Eckel, Amy Hess Fischl, George Guthrie, James O Hill, Mick Kumwenda, R David Leslie, Darin E Olson, Paolo Pozzilli, Sandra L Weber, Guillermo E Umpierrez
Primary prevention of Type 2 Diabetes (T2D) should be achievable through the implementation of early and sustainable measures. Such prevention follows from addressing modifiable risk factors that predispose an individual to prediabetes, which then gradually progresses to T2D. Several randomised control studies that have found success in preventing the progression to T2D in high-risk populations1,2 have identified early and intensive intervention based on an individualised prevention model as the key factor for participant benefit...
May 14, 2018: Diabetes/metabolism Research and Reviews
Philippe Thuillier, Emmanuel Sonnet, Zarrin Alavi, Nathalie Roudaut, Emmanuel Nowak, Angélina Dion, Véronique Kerlan
BACKGROUND: The objective was to compare glycemic control between pre- and post-prandial bolus administration (15min before (PRE) or immediately after the meal (POST)) in patients with type 1 diabetes using insulin pump and real time continuous glucose monitoring (RT-CGM). METHODS: Between September 2015 and February 2016, a single-centre, open randomized, two-way crossover study of patients on bolus insulin aspart administration was conducted during two 14-days periods and according to two administration regimen schedules(...
May 10, 2018: Diabetes/metabolism Research and Reviews
Hong Zhou, Yonghong Sun, Lihui Zhang, Wenyuan Kang, Na Li, Yongjun Li
AIMS: To understand the roles of the RhoA/ROCK and MAPK pathways in high glucose (HG)-induced apoptosis and oxidative stress in cardiomyocytes. MATERIALS AND METHODS: Neonatal rat cardiomyocytes were cultured in DMEM, supplemented with 5.5 or 30 mmol/L D-glucose, in the presence or absence of fasudil (50 or 100 μM), SB203580, SP600125 or PD98059 (10 μM, respectively). The percentage of early apoptotic cardiomyocytes was evaluated using flow cytometry. The SOD activity and MDA contents in the cellular supernatants were measured...
May 9, 2018: Diabetes/metabolism Research and Reviews
Barbara Bohn, Arthur Grünerbel, Marcus Altmeier, Carsten Giesche, Martin Pfeifer, Christian Wagner, Nikolai Heise, Frank Best, Peter Fasching, Reinhard W Holl
AIMS: The diabetic foot syndrome (DFS) is a serious complication in patients with diabetes increasing the risk for minor/major amputations. This analysis aimed to examine differences in diabetes patients with or without DFS stratified by type 1 (T1D) or type 2 diabetes (T2D). MATERIAL AND METHODS: Adult patients (≥20y of age) with diabetes from the German/Austrian DPV-registry were included. The cross-sectional study comprised 45,722 subjects with T1D (nDFS =2,966) and 313,264 with T2D (nDFS =30,904)...
May 3, 2018: Diabetes/metabolism Research and Reviews
Tamsin Santos, Janaka Lovell, Kerrie Shiell, Marilyn Johnson, Joseph E Ibrahim
INTRODUCTION: Self-management is integral to effective chronic disease management. Cognitive impairments (CogImp) associated with dementia have not previously been reviewed in diabetes mellitus (DM) self-care. AIM: (i) Whether CogImp associated with dementia impact self-care. (ii) Whether specific CogImp affects key DM self-care processes. METHOD: A systematic literature search with a narrative review was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines...
April 29, 2018: Diabetes/metabolism Research and Reviews
Venu Gopal Jonnalagadda, Harish Prabhanna Char, Pavan Kumar Samudrala
No abstract text is available yet for this article.
April 27, 2018: Diabetes/metabolism Research and Reviews
Jacob V Stidsen, Jan E Henriksen, Michael H Olsen, Reimar W Thomsen, Jens S Nielsen, Jørgen Rungby, Sinna P Ulrichsen, Klara Berencsi, Johnny A Kahlert, Søren G Friborg, Ivan Brandslund, Aneta A Nielsen, Jens S Christiansen, Henrik T Sørensen, Thomas B Olesen, Henning Beck-Nielsen
BACKGROUND: Type 2 diabetes may be a more heterogeneous disease than previously thought. Better understanding of pathophysiological subphenotypes could lead to more individualized diabetes treatment. We examined the characteristics of different phenotypes among 5813 Danish patients with new clinically diagnosed type 2 diabetes. METHODS: We first identified all patients with rare subtypes of diabetes, latent autoimmune diabetes of adults (LADA), secondary diabetes, or glucocorticoid-associated diabetes...
April 26, 2018: Diabetes/metabolism Research and Reviews
Ernesto Maddaloni, Raffaella Buzzetti
No abstract text is available yet for this article.
April 19, 2018: Diabetes/metabolism Research and Reviews
Rachel Dankner, Laurence S Freedman, Hertzel Gerstein, Jesse Roth, Lital Keinan-Boker
Pancreatic cancer has an extremely highly case fatality. Diabetes is a well-established strong risk factor for pancreatic cancer. Compared to a non-diabetic population, we previously reported a 15- and 14-fold greater risk for detecting pancreatic cancer during the first year after diagnosing diabetes in adult women and men, respectively, which dropped during the second year to 5.4-fold and 3.5-fold, respectively, and stabilized around 3-fold for the rest of the 11-year follow up in our historical cohort. The population attributable risk (PAR) during the 11-year period was 13...
April 19, 2018: Diabetes/metabolism Research and Reviews
Giuseppina T Russo, Carlo B Giorda, Stefania Cercone, Salvatore De Cosmo, Antonio Nicolucci, Domenico Cucinotta
BACKGROUND: Type 2 diabetes mellitus (T2DM) is associated with a progressive deterioration in beta cell function and loss of glycaemic control. Clinical predictors of beta cell failure are needed to guide appropriate therapy. METHODS: A prospective evaluation of a large set of potential predictors of beta cell stress, measured as change in the proinsulin/insulin (PI/I) ratio, was conducted in a cohort of 235 outpatients with T2DM on stable treatment with oral hypoglycaemic agents or diet followed-up for ~4 years (median value 3...
April 18, 2018: Diabetes/metabolism Research and Reviews
Miyang Luo, Kristin Hui Xian Tan, Chuen Seng Tan, Wei Yen Lim, E Shyong Tai, Kavita Venkataraman
BACKGROUND: This study aimed to review studies that identified patterns of longitudinal HbA1c trends in patients with diabetes, and to summarize factors and outcomes associated with distinct trajectory patterns. METHODS: PubMed and Web of Science were systematically searched for studies examining HbA1c trends among diabetes patients from database inception through September 2017. Articles were included if they met the following inclusion criteria: a) longitudinal study of subjects with diabetes only, b) use of serial measurements of HbA1c; and c) analysis of the trend of HbA1c using group-based trajectory approaches...
April 17, 2018: Diabetes/metabolism Research and Reviews
Sandra Aparecida Dos Reis, Maria do Carmo Gouveia Peluzio, Josefina Bressan
The intestinal microbiota has come to be considered an additional risk factor for the development of metabolic diseases. Considering the potential role of antimicrobials as modulators of the intestinal microbiota, they have been investigated for use in the adjuvant treatment of obesity and insulin resistance. In this regard, the present manuscript aimed to review the effect of regular use of antimicrobials on the treatment of obesity and/or IR, as well as its associated mechanisms. The regular use of antimicrobials does not seem to influence the body weight and adiposity of its consumer...
April 16, 2018: Diabetes/metabolism Research and Reviews
Pernille Kihl, Lukasz Krych, Karsten Buschard, Johnna D Wesley, Witold Kot, Axel Kornerup Hansen, Dennis S Nielsen, Matthias G Von Herrath
BACKGROUND: Oral insulin as a preventive strategy and/or treatment of type 1 diabetes has been the target of much research. Producing oral insulins is a complex and challenging task, with numerous pitfalls, due to both physiological, physical and biochemical barriers. Our aim was to determine the impact of oral insulin on the delicate gut microbiota composition. METHODS: Female NOD mice were given oral porcine insulin two times a week from 5 weeks of age for 4 weeks, and then subsequently once a week for 21 weeks, or until euthanized...
April 10, 2018: Diabetes/metabolism Research and Reviews
Xue Bao, Yeqing Gu, Qing Zhang, Li Liu, Ge Meng, Hongmei Wu, Yang Xia, Hongbin Shi, Honglei Wang, Shaomei Sun, Xing Wang, Ming Zhou, Qiyu Jia, Kun Song, Kaijun Niu
AIMS: As an insulin target tissue, skeletal muscle is inversely related to type 2 diabetes mellitus (T2DM). Serum creatinine originates mainly from creatine in muscle and is considered as a reliable surrogate marker for muscle mass in apparently healthy subjects. It is therefore hypothesized that low serum creatinine could effectively predict increased risk of T2DM. Yet information is scarce regarding the longitudinal relationship between serum creatinine and T2DM. This study aims to investigate this relation in a large general population of both men and women...
April 7, 2018: Diabetes/metabolism Research and Reviews
Sarah L Craig, Victor A Gault, Nigel Irwin
Xenin-25 is a 25 amino acid peptide hormone co-secreted from the same enteroendocrine K-cell as the incretin peptide glucose-dependent insulinotropic polypeptide (GIP). There is no known specific receptor for xenin-25, but studies suggest that at least some biological actions may be mediated through interaction with the neurotensin receptor. Original investigation into the physiological significance of xenin-25 focussed on effects related to gastrointestinal transit and satiety. However, xenin-25 has been demonstrated in pancreatic islets and recently shown to possess actions in relation to the regulation of insulin and glucagon secretion, as well as promoting beta-cell survival...
April 6, 2018: Diabetes/metabolism Research and Reviews
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