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Diabetes/metabolism Research and Reviews

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https://www.readbyqxmd.com/read/27933750/comparing-glucose-and-hemoglobin-a1c-diagnostic-tests-among-a-high-metabolic-risk-hispanic-population
#1
Mónica A Vega-Vázquez, Margarita Ramirez-Vick, Francisco J Muñoz-Torres, Loida A González-Rodríguez, Kaumudi Joshipura
AIMS: Compare HbA1c diagnostic tests for pre-diabetes and diabetes with plasma glucose criteria (PGC), and compare the metabolic profiles of people classified by HbA1c versus by glucose levels. METHODS: Participants were recruited for the San Juan Overweight Adults Longitudinal Study (SOALS). Were primarily Hispanic (98%), without previously diagnosed diabetes, and aged 40-65 years. Participants classified as normal glycemic, pre-diabetes or diabetes based on baseline HbA1c and PGC, were compared with respect to baseline cardiometabolic factors...
December 9, 2016: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/27883367/a-drop-in-the-circulating-concentrations-of-soluble-receptor-for-ages-is-associated-with-seroconversion-to-autoantibody-positivity-but-not-with-subsequent-progression-to-clinical-disease-in-children-en-route-to-type-1-diabetes
#2
K M Salonen, S J Ryhänen, J M Forbes, T Härkönen, J Ilonen, O Simell, R Veijola, P-H Groop, M Knip
BACKGROUND: Advanced glycation end products (AGEs) and their interaction with the receptor for advanced glycation end products (RAGE) have been studied for their role in the pathogenesis and complications of type 1 diabetes. Decreased concentrations of soluble RAGE (sRAGE) have been reported in acute autoimmune inflammation. We set out to analyze the changes in (sRAGE) concentration during preclinical diabetes in children seroconverting to islet autoantibody positivity. METHODS: We measured serum concentrations of sRAGE in 168 children who progressed to clinical disease and 43 children who turned positive for at least two diabetes-associated autoantibodies but remained non-diabetic...
November 24, 2016: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/27883358/negative-pressure-wound-therapy-inhibit-inflammation-by-up-regulating-atf-3-and-down-regulating-nuclear-factor-%C3%AE%C2%BAb-in-diabetic-patients-with-foot-ulcerations
#3
T Wang, R He, J Zhao, J C Mei, M Z Shao, Y Pan, J Zhang, H S Wu, M Yu, W C Yan, L M Liu, F Liu, W P Jia
BACKGROUND: Negative pressure wound therapy (NPWT) was one of the most important treatments of diabetic foot, but the underlying mechanisms still remain elusive. This study aimed to evaluate the inflammatory signals involved in the effects of NPWT on diabetic foot ulcers. METHODS: We enrolled 22 patients with diabetic foot ulceration, eleven treated with NPWT and others treated with traditional debridement. All the patients were treated and observed for 1 week...
November 24, 2016: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/27862917/assessing-variation-across-eight-established-east-asian-loci-for-type-2-diabetes-in-american-indians-suggestive-evidence-for-new-sex-specific-diabetes-signals-in-glis3-and-zfand3
#4
Yunhua L Muller, Paolo Piaggi, Peng Chen, Gregory Wiessner, Chidinma Okani, Sayuko Kobes, William C Knowler, Clifton Bogardus, Robert L Hanson, Leslie J Baier
BACKGROUND: Eight new loci for type 2 diabetes (T2D) were identified in an East Asian genome-wide association study meta-analysis. We assess tag SNPs across these loci for associations with T2D in American Indians. METHODS: 435 SNPs which tag (r(2)  ≥ 0.85) common variation across the 8 loci were analyzed for association with T2D (n = 7710), early-onset T2D (n = 1060), body mass index (n = 6839), insulin sensitivity (n = 555) and insulin secretion (n = 298)...
November 8, 2016: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/27862843/elevated-circulating-neuregulin4-level-in-patients-with-diabetes
#5
Lu-Lu Chen, Miao-Miao Peng, Jiao-Yue Zhang, Xiang Hu, Jie Min, Qiu-Lan Huang, Li-Min Wan
BACKGROUND: Neuregulin4 is a novel adipokine expressed in adipose tissues, enriched in brown adipose tissue (BAT) and able to improve whole-body metabolism in rodent, thus having the potential to treat obesity-associated disorders such as diabetes. However, the association between serum Neuregulin4 levels and diabetes risk in human remains unclear. This study was designed to examine circulating Neuregulin4 levels in subjects with different glucose tolerance status. METHODS: Age-, sex- and BMI-matched subjects (n = 310: 83 normal glucose tolerance (NGT), 129 prediabetes and 96 diabetes) from the Risk Evaluation of Cancers in Chinese Diabetic Individuals: A Longitudinal study (Reaction study) were included...
November 8, 2016: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/27860198/diabetes-mellitus-and-long-term-mortality-of-ovarian-cancer-patients-a-systematic-review-and-meta-analysis-of-12-cohort-studies
#6
Dongyu Zhang, Yuan Zhao, Tengteng Wang, Yuzhi Xi, Nan Li, Hongtai Huang
AIM: Ovarian cancer (OC) is the sixth most common cancer among women, and its prognosis is not favorable. Diabetes mellitus (DM) is hypothesized to be associated with a higher mortality in ovarian cancer patients, but evidence is inconsistent. Thus, we aim to investigate if DM is associated with the long-term all-cause and long-term cancer-specific mortality in ovarian cancer patients by synthesizing available epidemiologic evidences. METHODS: We used 4 electronic databases (PubMed, EMBASE, Web of Science, and Scopus) to search for eligible articles...
November 8, 2016: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/27792855/minor-amputation-does-not-negatively-affect-health-related-quality-of-life-as-compared-with-conservative-treatment-in-patients-with-a-diabetic-foot-ulcer-an-observational-study
#7
K Pickwell, V Siersma, M Kars, J Apelqvist, K Bakker, M Edmonds, P Holstein, A Jirkovská, E B Jude, D Mauricio, A Piaggesi, H Reike, M Spraul, L Uccioli, V Urbancic, K van Acker, J van Baal, N Schaper
BACKGROUND: Health-related quality of life (HRQoL) is poor in patients with persistent diabetic foot ulcers and poor HRQoL predicts worse outcomes in these patients. Amputation is often considered a treatment failure, which is why conservative treatment is generally preferred over amputation. However, it is unclear whether minor amputation negatively affects HRQoL compared with conservative treatment in patients with diabetic foot ulcers. METHODS: In the cohort of the multicenter, prospective, observational Eurodiale study, we determined difference in change of HRQoL measured by EQ-5D between patients with a diabetic foot ulcers that healed after conservative treatment (n = 676) and after minor amputation (n = 145)...
October 28, 2016: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/27786404/risk-of-contrast-induced-nephropathy-in-diabetic-patients-affected-by-critical-limb-ischemia-and-diabetic-foot-ulcers-treated-by-percutaneous-transluminal-angioplasty-of-lower-limbs
#8
Marco Meloni, Laura Giurato, Valentina Izzo, Matteo Stefanini, Roberto Gandini, Luigi Uccioli
BACKGROUND: To evaluate the risk of contrast induced nephropathy (CIN) in diabetic patients with critical limb ischemia (CLI) and foot ulcers (FUs) treated by percutaneous transluminal angioplasty (PTA) of lower limbs. METHODS: The study group was composed of 145 diabetic patients who underwent a limb salvage protocol because of CLI and FUs between 2012 and 2015. All patients received a prophylactic strategy against the administration of contrast medium (CM). Serum creatinine levels (SCr) were evaluated the day of procedure and for three days after...
October 27, 2016: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/27764529/t-lymphocyte-and-glycemic-status-after-vitamin-d-treatment-in-type-1-diabetes-a-randomized-controlled-trial-with-sequential-crossover
#9
D Bogdanou, M Penna-Martinez, N Filmann, T L Chung, Y Moran-Auth, J Wehrle, C Cappel, S Huenecke, E Herrmann, U Koehl, K Badenhoop
BACKGROUND: Type 1 diabetes mellitus (T1D) is mediated by autoaggressive T effector cells with an underlying regulatory T-cell (Treg) defect. Vitamin D deficiency is highly prevalent in T1D, which can aggravate immune dysfunction. High-dose vitamin D treatment may enhance Tregs and improve metabolism in T1D patients. METHODS: In a randomized double-blind placebo-controlled trial with crossover design, patients received either for 3 months cholecalciferol 4000 IU/d followed by 3 months placebo or the sequential alternative...
October 20, 2016: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/27726307/high-prevalence-of-diabetes-specific-autoimmunity-in-first-degree-relatives-of-sardinian-patients-with-type-1-diabetes
#10
M Incani, C Serafini, C Satta, L Perra, F Scano, P Frongia, R Ricciardi, C Ripoli, M Soro, A Strazzera, S Zampetti, R Buzzetti, M G Cavallo, E Cossu, M G Baroni
BACKGROUND: The incidence of type 1 diabetes mellitus (T1DM) in Sardinia is among the highest in the world (44.8 cases/100,000 person-years). Recommendations of the Immunology of Diabetes Society advise evaluating autoantibody positivity in first-degree relatives (FDRs) of patients with T1DM, for their higher risk to develop the disease. The aim of this study was to determine the prevalence of beta-cell autoimmunity in FDRs of T1DM patients in Sardinia. METHODS: A total of 188 Sardinian families were recruited in collaboration between diabetes and pediatric units of university and district hospitals in Sardinia...
October 11, 2016: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/27667797/glycemic-control-and-safety-in-chinese-patients-with-type-2-diabetes-mellitus-who-switched-from-premixed-insulin-to-insulin-glargine-plus-oral-antidiabetics-a-large-prospective-observational-study
#11
Bo Zhang, Jing Zhao, Wenying Yang
BACKGROUND: In some circumstances, the premixed insulin should be switched to alternative therapy. The effectiveness and safety of switching from premixed insulin to insulin glargine plus oral antidiabetic drugs (OADs) in Chinese patients with type 2 diabetes mellitus (T2DM) have not been clarified, and will be assessed in this study. METHODS: Chinese patients with T2DM (2,013 men and women aged 18 to 75 years) who had received premixed insulin ± OADs for ≥ 3 months with glycated hemoglobin (HbA1c) ≤ 10% were enrolled in a prospective, observational study conducted at 53 hospitals across China...
September 26, 2016: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/27667744/carboxylated-and-undercarboxylated-osteocalcin-in-metabolic-complications-of-human-obesity-and-prediabetes
#12
Urszula Razny, Danuta Fedak, Beata Kiec-Wilk, Joanna Goralska, Anna Gruca, Anna Zdzienicka, Malgorzata Kiec-Klimczak, Bogdan Solnica, Alicja Hubalewska-Dydejczyk, Malgorzata Malczewska-Malec
BACKGROUND: Carboxylated osteocalcin (Gla-OC) participates in bone remodeling, whereas the undercarboxylated form (Glu-OC) takes part in energy metabolism. This study was undertaken to compare the blood levels of Glu-OC and Gla-OC in non-obese, healthy obese as well as prediabetic volunteers and correlate it with the metabolic markers of insulin resistance and early markers of inflammation. METHODS: Non-obese (BMI <30 kg/m(2) , n = 34) and obese subjects (>30 BMI <40 kg/m(2) , n = 98), both sexes, aged 25-65 years were divided into: healthy control, normal weight subjects, healthy obese and obese with biochemical markers of prediabetes and subgroups with obesity and low or high Gla-OC or Glu-OC and considered for statistical analysis...
September 26, 2016: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/27667672/passive-smoking-increased-risk-of-gestational-diabetes-mellitus-independently-and-synergistically-with-pre-pregnancy-obesity-in-tianjin-china
#13
Junhong Leng, Peng Wang, Ping Shao, Cuiping Zhang, Weiqin Li, Nan Li, Leishen Wang, Hairong Nan, Zhijie Yu, Gang Hu, Juliana Cn Chan, Xilin Yang
BACKGROUND: Passive smoking increased type 2 diabetes mellitus risk but it is uncertain whether it also increased gestational diabetes mellitus (GDM) risk. We aimed to examine the association of passive smoking during pregnancy and its interaction with maternal obesity for GDM. METHODS: From 2010 to 2012, 12,786 Chinese women underwent a 50-gram 1-hour glucose challenge test (GCT) at 24-28 weeks of gestation and further underwent a 75-gram 2-hour oral glucose tolerance test if the GCT result was ≥7...
September 26, 2016: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/27667505/the-importance-of-nonstop-treatment-after-delivery-for-pregnant-women-with-type-2-diabetes
#14
Yasue Omori, Keiko Yanagisawa, Asako Sato, Yasuko Uchigata
BACKGROUND: There are no reports of very long follow-up studies of pregnant women with type 2 diabetes after delivery. Here we describe cases of Japanese women whom we treated for 20 to 50 years after deliveries to investigate the relationship between blood glucose control and diabetic complications. METHODS: In Japan, the prevalence of type 1 diabetes is very low, and we have very few long-term follow-up cases with type 1 diabetes. Therefore, we chose to describe subjects with type 2 diabetes only...
September 26, 2016: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/27667324/nadolol-reduces-insulin-sensitivity-in-liver-cirrhosis-a-double-blind-randomized-cross-over-trial
#15
Wai Gin Lee, Rinki Murphy, John L McCall, Edward J Gane, Mattias Soop, Andrea Tura, Lindsay D Plank
BACKGROUND: Liver cirrhosis is frequently complicated by portal hypertension leading to increased mortality from variceal bleeding and hepatic decompensation. Non-cardioselective β-blockers reduce portal hypertension and prevent variceal bleeding in cirrhosis, but also impair glucose tolerance and insulin sensitivity in other settings. This study aimed to determine whether non-selective β-blockade with nadolol impairs glucose metabolism in liver cirrhosis. METHODS: A randomized, double-blind, placebo-controlled, cross-over trial of nadolol in cirrhotic patients examined insulin sensitivity, disposition index and glucose tolerance...
September 26, 2016: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/27778432/oral-presentation-clinical-diabetes-therapeutics
#16
(no author information available yet)
No abstract text is available yet for this article.
November 2016: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/27778431/poster-clinical-diabetes-therapeutics
#17
(no author information available yet)
No abstract text is available yet for this article.
November 2016: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/27778430/published-only-clinical-diabetes-therapeutics
#18
(no author information available yet)
No abstract text is available yet for this article.
November 2016: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/26991448/a-model-based-approach-to-sample-size-estimation-in-recent-onset-type-1-diabetes
#19
Brian N Bundy, Jeffrey P Krischer
BACKGROUND: The area under the curve C-peptide following a 2-h mixed meal tolerance test from 498 individuals enrolled on five prior TrialNet studies of recent onset type 1 diabetes from baseline to 12 months after enrolment were modelled to produce estimates of its rate of loss and variance. RESULTS: Age at diagnosis and baseline C-peptide were found to be significant predictors, and adjusting for these in an ANCOVA resulted in estimates with lower variance. CONCLUSIONS: Using these results as planning parameters for new studies results in a nearly 50% reduction in the target sample size...
November 2016: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/27103506/reduced-peripheral-blood-mtdna-content-is-associated-with-impaired-glucose-stimulated-islet-%C3%AE-cell-function-in-a-chinese-population-with-different-degrees-of-glucose-tolerance
#20
Mei-Cen Zhou, Lixin Zhu, Xiangli Cui, Linbo Feng, Xuefeng Zhao, Shuli He, Fan Ping, Wei Li, Yuxiu Li
AIMS: Our aim is to explore the associations between mitochondrial DNA (mtDNA) content and basal plasma glucose, plasma glucose after oral glucose administration and oxidative stress in a Chinese population with different levels of glucose tolerance. We also aimed to investigate the effect of mtDNA content on basal and oral glucose-stimulated insulin secretion. METHODS: Five hundred and fifty-six Chinese subjects underwent a 75-g, 2-h oral glucose tolerance test...
October 2016: Diabetes/metabolism Research and Reviews
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