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Diabetes/metabolism Research and Reviews

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https://www.readbyqxmd.com/read/28817237/dysregulation-of-wound-healing-mechanisms-in-diabetes-and-the-importance-of-negative-pressure-wound-therapy-npwt
#1
Mogher Khamaisi, Sarit Balanson
Diabetes is a serious disease with severe side effects and comorbidities. Diabetic foot with its chronic non-healing ulcers, or diabetic food ulcers (DFU) as they are commonly called, can be devastating, even leading to amputation. Many therapies exist to assist and improve wound healing. One exciting discovery is the use of negative pressure wound therapy (NPWT) as an adjunct to standard treatment. Few studies have substantively explored the molecular mechanisms of NPWT and why we see improved wound healing, a concept that demands more research...
August 17, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28817230/recent-findings-on-fulminant-type-1-diabetes
#2
REVIEW
Lan Liu, Ling Zeng, Dan Sang, Zeyuan Lu, Jie Shen
Fulminant type 1 diabetes (fT1D) is a new subtype of type 1 diabetes proposed by Imagawa in 2000. It is a clinical syndrome characterized by a markedly rapid and almost complete destruction of pancreatic β cells. Metabolic derangement is more severe in this subtype than in autoimmune type 1 diabetes. The incidence of fT1D is associated with HLA DRB1*04:05DQB1*04:01, both innate and acquired immune disorders might contribute to the development of fT1D. The presence of specific innate immune responses to enterovirus infection connected with enhanced adoptive immune pathways responsible for aggressive β cell toxicity in fT1D...
August 17, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28806491/the-association-between-dysregulated-adipocytokines-in-early-pregnancy-and-development-of-gestational-diabetes
#3
Sally K Abell, Soulmaz Shorakae, Cheryce L Harrison, Danielle Hiam, Alba Moreno-Asso, Nigel K Stepto, Barbora De Courten, Helena J Teede
BACKGROUND: To investigate the association of adipocytokines and other inflammatory markers with development of GDM. METHODS: Serum adipocytokines and inflammatory markers were studied at 12-15 weeks gestation using biobanked control samples from a randomised trial. Study participants were identified as high risk for GDM using a validated clinical risk prediction tool. Markers were tested using commercial ELISA kits for high molecular weight (HMW) adiponectin, interleukin-6 (IL-6), plasminogen activator inhibitor-1, visfatin, omentin-1, sex-hormone binding globulin, monocyte chemoattractant protein and asymmetrical dimethylarginine...
August 14, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28806487/gut-microbiome-response-to-short-term-dietary-interventions-in-reactive-hypoglycemia-subjects
#4
Sara Quercia, Silvia Turroni, Jessica Fiori, Matteo Soverini, Simone Rampelli, Elena Biagi, Andrea Castagnetti, Clarissa Consolandi, Marco Severgnini, Mario Pianesi, Francesco Fallucca, Paolo Pozzilli, Patrizia Brigidi, Marco Candela
BACKGROUND: Reactive hypoglycemia (RH) is a metabolic disorder that provokes severe hypoglycemic episodes after meal. Over recent years, the gut microbiota (GM) has been recognized as potential target for the control of metabolic diseases, and the possibility to correct GM dysbioses through diet, favoring the recovery of metabolic homeostasis, has been considered. METHODS: We investigate the impact of two short-term (3-day) nutritional interventions, based on the macrobiotic Ma-Pi 2 diet and a control Mediterranean diet, on the structure and functionality of the GM in 12 patients affected by RH...
August 14, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28755385/building-and-validating-a-prediction-model-for-pediatric-type-1-diabetes-risk-using-next-generation-targeted-sequencing-of-class-ii-hla-genes
#5
Lue Ping Zhao, Annelie Carlsson, Helena Elding Larsson, Gun Forsander, Sten A Ivarsson, Ingrid Kockum, Johnny Ludvigsson, Claude Marcus, Martina Persson, Ulf Samuelsson, Eva Örtqvist, Chul-Woo Pyo, Hamid Bolouri, Michael Zhao, Wyatt C Nelson, Daniel E Geraghty, Åke Lernmark
AIM: It is of interest to predict possible lifetime risk of type diabetes (T1D) in young children for recruiting high-risk subjects into longitudinal studies of effective prevention strategies. METHODS: Utilizing a case-control study in Sweden, we applied a recently developed next generation targeted sequencing (NGTS) technology to genotype class II genes, and applied an object-oriented regression (OOR) to build and validate a prediction model for T1D. RESULTS: In the training set, estimated risk scores were significantly different between patients and controls (P=8...
July 29, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28753251/liraglutide-mitigates-tnf-%C3%AE-induced-pro-atherogenic-changes-and-microvesicles-release-in-huvec-from-diabetic-women
#6
Pamela Di Tomo, Paola Lanuti, Natalia Di Pietro, Maria Pompea Antonia Baldassarre, Marco Marchisio, Assunta Pandolfi, Agostino Consoli, Gloria Formoso
BACKGROUND: To evaluate whether exposure to GLP-1 receptor agonist Liraglutide could modulate pro-atherogenic alterations previously observed in endothelial cells obtained by women affected by gestational diabetes, thus exposed in vivo to hyperglycemia, oxidative stress and inflammation and to evaluate endothelial microvesicles (EMV) release, a new reliable biomarker of vascular stress/damage. METHODS: we studied Liraglutide effects and its plausible molecular mechanisms on monocyte cells adhesion and adhesion molecules expression and membrane exposure in control (C-) Human Umbilical Vein Endothelial Cells (HUVEC) as well as in HUVEC of women affected by gestational diabetes (GD) exposed in vitro to TNF-α...
July 28, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28736981/ketoacidosis-and-sglt2-inhibitor-treatment-analysis-of-faers-data
#7
Jenny E Blau, Sri Harsha Tella, Simeon I Taylor, Kristina I Rother
BACKGROUND: Regulatory agencies have concluded that sodium glucose cotransporter 2 (SGLT2) inhibitors lead to ketoacidosis, but published literature on this point remains controversial. METHODS: We searched the FDA Adverse Event Reporting System (FAERS) for reports of acidosis in patients treated with canagliflozin, dapagliflozin, or empagliflozin (from the date of each drug's FDA approval until May 15, 2015). We compared the number of SGLT2 inhibitor-related reports to reports of acidosis in patients treated with the two most commonly used DPP4 inhibitors: sitagliptin and saxagliptin...
July 24, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28731619/new-onset-diabetes-after-kidney-transplantation-is-associated-with-increased-mortality-a-retrospective-cohort-study
#8
L Cooper, N Oz, G Fishman, T Shohat, R Rahamimov, E Mor, H Green, A Grossman
OBJECTIVE: Clinical outcomes in individuals with new onset diabetes after transplantation (NODAT) and the optimal treatment for this complication are poorly characterized. This study was intended to better define these issues. METHODS: Patients who underwent kidney transplantation and did not have diabetes prior to transplantation were included in the study and clinical outcomes were compared between those who developed NODAT and those who did not. In those who developed NODAT, oral therapy was compared with insulin based therapy...
July 21, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28731290/autoantibodies-against-pfdn2-are-associated-with-an-increased-risk-of-type-2-diabetes-a-case-control-study
#9
Douglas C Chang, Paolo Piaggi, Robert L Hanson, William C Knowler, Clifton Bogardus, Jonathan Krakoff
BACKGROUND: The adaptive immune system is involved in type 2 diabetes mellitus (T2DM), indicating the presence of unidentified autoantibodies that might be useful biomarkers for emerging immunomodulatory therapy. A prior microarray study with a small number of participants suggested the association of novel autoantibodies with T2DM in Southwest American Indians (SAIs). We therefore sought to determine whether antibodies against 14 target proteins are associated with T2DM in a large case-control study...
July 21, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28731281/glycaemic-control-and-the-risk-of-hospitalisation-for-infection-in-patients-with-type-2-diabetes-hong-kong-diabetes-registry
#10
Andrea O Y Luk, Eric S H Lau, Kitty K T Cheung, Alice P Kong, Ronald C W Ma, Risa Ozaki, Francis C C Chow, Wing-Yee So, Juliana C N Chan
BACKGROUND: Infection occurs more commonly in diabetic compared to general population and is an under-recognised but important morbidity in patients with diabetes. We examined the impact of glycaemic control on hospitalisation for infection in a large prospective cohort of Chinese adults with type 2 diabetes. METHODS: Between July 1994 and June 2014, 22,846 patients with type 2 diabetes underwent detailed assessment of metabolic control and diabetes complications...
July 21, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28730683/ectopic-fat-accumulation-in-the-pancreas-and-its-biomarkers-a-systematic-review-and-meta-analysis
#11
REVIEW
Ruma G Singh, Harry D Yoon, Sally D Poppitt, Lindsay D Plank, Maxim S Petrov
AIM: Presence of fatty pancreas increases the risk of metabolic co-morbidities. Detection and quantification of pancreatic fat is not a routine clinical practice, at least in part because of need to use expensive imaging techniques. We aimed to systematically review common markers of pancreatic fat in blood and to investigate differences in these markers associated with fatty pancreas. METHODS: The search was conducted in three databases (EMBASE, Scopus, and MEDLINE)...
July 21, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28722798/angptl8-betatrophin-role-in-diabetes-and-metabolic-diseases
#12
REVIEW
Mohamed Abu-Farha, Jehad Abubaker, Jaakko Tuomilehto
Diabetes is a major disease worldwide that is reaching epidemic stage. Its increased prevalence as well as its association with a high number of complications such as cardiovascular diseases, nephropathy and retinopathy makes it an important disease for investigation. ANGPTL8 is a recently identified hormone that has been associated with two functionally important processes in the development of type 2 diabetes, insulin resistance as well as lipid metabolism. Initial work has showed that ANGPTL8 was expressed in liver, white adipose and brown adipose tissues...
July 19, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28719154/progression-of-skin-autofluorescence-of-ages-over-4-years-in-patients-with-type-1-diabetes
#13
Kalina Rajaobelina, Catherine Helmer, Fritz-Line Vélayoudom-Céphise, Sovanndany Nov, Blandine Farges, Emilie Pupier, Laurence Blanco, Marie Hugo, Henri Gin, Vincent Rigalleau
BACKGROUND: The deposit of Advanced Glycation End-products (AGEs) is involved in diabetic complications. It can be evaluated by measuring the skin autofluorescence (sAF). We searched whether sAF progressed over 4 years in Type 1 Diabetes, and analysed its relationship with the development of nephropathy. METHODS: Two measurements of sAF was realized on 154 patients during years 2009 and 2013. Baseline factors associated to the progression of sAF were analyzed by multivariate regression analysis...
July 18, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28719027/marker-of-coxsackievirus-b4-infection-in-saliva-of-patients-with-type-1-diabetes
#14
F Badia-Boungou, F Sane, E K Alidjinou, M Ternois, P A Opoko, J Haddad, C Stukens, C Lefevre, I Gueorguieva, M Hamze, M Ismail, J Weill, H G Monabéka, E Bouenizabila, D Moukassa, A A Abena, D Hober
BACKGROUND: Coxsackieviruses B (CV-B) are enteroviruses that have been reported to play a role in the pathogenesis of type 1 diabetes. Enteroviral RNA was detected in the gut mucosa of patients. The mucosal immunity is an interconnected network, therefore the response to enteroviruses possibly present in the gastrointestinal mucosa can be reflected by specific antibodies in the saliva. In the present study the anti-CV-B neutralizing activity of saliva samples from patients with type 1 diabetes was investigated...
July 18, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28692149/animal-models-of-human-type-1-diabetes-for-evaluating-combination-therapies-and-successful-translation-to-the-patient-with-type-1-diabetes
#15
REVIEW
Sigurd Lenzen
Animal models of human type 1 diabetes will be of a great importance for the evaluation of new combination therapies with curative potential. However, reliable predictive power for successful translation to patients with type 1 diabetes is crucial. This will be particularly important in the future when evaluating success of new combination therapies which show great promise for preservation and restoration of beta cell mass and thereby reverse the type 1 diabetic hyperglycaemia. But not all spontaneous animal models are equally well suited for this purpose...
July 10, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28609607/blood-pathway-analyses-reveal-differences-between-prediabetic-subjects-with-or-without-dyslipidaemia-the-cardiovascular-risk-in-young-finns-study
#16
Jaakko Laaksonen, Tuukka Taipale, Ilkka Seppälä, Emma Raitoharju, Nina Mononen, Leo-Pekka Lyytikäinen, Melanie Waldenberger, Thomas Illig, Nina Hutri-Kähönen, Tapani Rönnemaa, Markus Juonala, Jorma Viikari, Mika Kähönen, Olli Raitakari, Terho Lehtimäki
BACKGROUND: Prediabetes (PR) often occurs together with dyslipidaemia (D), which is paradoxically treated with statins predisposing to type 2 diabetes mellitus. We examined peripheral blood pathway profiles in prediabetic subjects with (PRD ) and without dyslipidaemia (PR0 ) and compared these to non-prediabetic controls (C) without dyslipidaemia (C0 ). METHODS: The participants were from the Cardiovascular Risk in Young Finns Study, including 1,240 subjects aged 34-49 years...
June 13, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28609547/intensive-insulin-therapy-combined-with-metformin-is-associated-with-reduction-in-both-glucose-variability-and-nocturnal-hypoglycaemia-in-patients-with-type-2-diabetes
#17
Yifei Zhang, Zhiyun Zhao, Shujie Wang, Wei Zhu, Yiran Jiang, Shouyue Sun, Chen Chen, Kai Wang, Liangshan Mu, Jinyi Cao, Yingxia Zhou, Weiqiong Gu, Jie Hong, Weiqing Wang, Guang Ning
BACKGROUND: The effect on glucose variability in patients with intensive insulin therapy has not been fully understood. This observational study investigated the different glucose variability and hypoglycaemia patterns in type 2 diabetes patients treated with continuous subcutaneous insulin infusion (CSII) or multiple daily injections (MDI) with or without metformin administration. METHODS: During hospitalization, a total of 501 patients with poor glycaemic control and in initial treatment with either CSII alone (n = 187), CSII + Metformin (n = 81), MDI alone (n = 146), or MDI + Metformin (n = 87) were involved in the final analysis...
June 13, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28608942/a-risk-score-model-for-predicting-risk-of-type-2-diabetes-mellitus-in-a-rural-chinese-adult-population-a-cohort-study-with-a-6-year-follow-up
#18
Hongyan Zhang, Chongjian Wang, Yongcheng Ren, Bingyuan Wang, Xiangyu Yang, Yang Zhao, Chengyi Han, Junmei Zhou, Lu Zhang, Minjie Qi, Yujia Zhai, Chao Pang, Lei Yin, Jingzhi Zhao, Dongsheng Hu, Ming Zhang
BACKGROUND: Several prediction tools have been developed to identify people with T2DM and to quantify the probability of developing T2DM. However, most of the risk models were constructed based on cross-sectional studies and tea-drinking was not included. METHODS: A total of 15,768 participants without known T2DM were followed up from 2007-2008 to 2013-2014; 12,654 were randomly assigned to the derivation dataset and 3114 to the validation dataset. We constructed a risk-score model for T2DM by using a Cox proportional-hazards model...
June 13, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28608654/comparative-evaluation-of-probiotics-effects-on-plasma-glucose-lipid-and-insulin-levels-in-streptozotocin-induced-diabetic-rats
#19
Faeghe Memarrast, Soudeh Ghafouri-Fard, Sedighe Kolivand, Saeedeh Jafary-Nodooshan, Nadia Neyazi, Esmaeil Sadroddiny, Elahe Motevaseli
BACKGROUND: Diabetes is a chronic disorder caused by the relative decrease in insulin production from the pancreas, tissue resistance to insulin, or both of them. Daily consumption of probiotics, particularly Lactobacilli has been proposed as a new strategy for prevention or control of diabetes. METHODS: In the current study, the effects of various probiotics including Lactobacillus reuteri (L.reuteri), Lactobacillus crispatus (L.crispatus) and Bacillus subtilis on the levels of blood glucose, lipid and insulin as well as HbA1c were investigated in rat models of streptozotocin (STZ)-induced diabetes and compared with metformin...
June 13, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28580761/commentary-passive-smoking-as-an-independent-risk-factor-for-gestational-diabetes-that-synergizes-with-pre-pregnancy-obesity-in-urban-chinese-women
#20
Mary R Loeken
There are high priority public health and legislative efforts around the world to reduce smoking and to reduce the spaces where smoking is allowable. These efforts are aimed at minimizing not just the adverse health effects of active smoking, but also the adverse health effects of passive cigarette smoke exposure. While many cultures and societies make protection of the pregnant woman and her about-to-be-born-newborn a priority, the importance of protecting them from passive smoking that is prevalent in many modern societies has not been reported...
June 5, 2017: Diabetes/metabolism Research and Reviews
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