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Diabetes/metabolism Research and Reviews

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https://www.readbyqxmd.com/read/28444955/serum-uric-acid-levels-are-associated-with-increased-risk-of-newly-developed-diabetic-retinopathy-among-japanese-male-patients-with-type-2-diabetes-a-prospective-cohort-study-diabetes-distress-and-care-registry-at-tenri-ddcrt-13
#1
Hirohito Kuwata, Shintaro Okamura, Yasuaki Hayashino, Satoru Tsujii, Hitoshi Ishii
OBJECTIVE: We assessed the prospective association between baseline serum uric acid (SUA) levels and consequent risk of developing diabetic retinopathy (DR). RESEARCH DESIGN AND METHODS: Data for 1839 type 2 diabetes patients without DR were obtained from a Japanese diabetes registry. A Cox proportional hazards model with time-varying exposure information by sex was used and adjusted for potential confounders to assess the independent correlations between baseline SUA levels and incidence rate of DR...
April 26, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28444863/the-prevalence-of-type-2-diabetes-in-urban-bo-sierra-leone-and-in-the-16-countries-of-the-west-africa-region
#2
Abu James Sundufu, Cecil N Bockarie, Kathryn H Jacobsen
BACKGROUND: The goal of this study was to measure the prevalence of diabetes among adults in urban Bo, Sierra Leone, and to compare the new result to the diabetes prevalence rates reported from studies across West Africa. METHODS: A total of 694 outpatients ages 18 and older at Bo Government Hospital were tested for diabetes between January 2012 and December 2014. Diabetes was defined as a fasting blood sugar level of ≥126 mg/dl (≥7.0 mmol/l). RESULTS: The overall prevalence of diabetes was 6...
April 26, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28440590/sodium-glucose-co-transporter-2-sglt2-inhibitors-and-fracture-risk-in-patients-with-type-2-diabetes-mellitus-a-meta-analysis
#3
Darin Ruanpeng, Patompong Ungprasert, Jutarat Sangtian, Tasma Harindhanavudhi
INTRODUCTION: Sodium glucose co-transporter 2 (SGLT2) inhibitors could potentially alter calcium and phosphate homeostasis and may increase the risk of bone fracture. METHODS: The current meta-analysis was conducted to investigate the fracture risk among patients with type 2 diabetes mellitus treated with SGLT2 inhibitors. Randomized controlled trials that compared the efficacy of SGLT2 inhibitors to placebo were identified. The risk ratios of fracture among patients who received SGLT2 inhibitors versus placebo were extracted from each study...
April 25, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28437854/is-there-sufficient-evidence-for-a-causal-association-between-antiretroviral-therapy-and-diabetes-in-hiv-infected-patients-a-meta-analysis
#4
REVIEW
Chidozie U Nduka, Saverio Stranges, Peter K Kimani, Ahmed M Sarki, Olalekan A Uthman
BACKGROUND: The association of antiretroviral therapy (ART) with diabetes is inconsistent and varies widely across primary epidemiological studies. A comprehensive and more precise estimate of this association is fundamental to establishing a plausible causal link between ART and diabetes. METHODS: We identified epidemiological studies that compared mean fasting plasma glucose (FPG) concentrations and proportions of diabetes and metabolic syndrome between HIV-infected patients naïve and exposed to ART...
April 24, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28371189/effect-of-glp-1-and-gip-on-c-peptide-secretion-after-glucagon-or-mixed-meal-tests-significance-in-assessing-beta-cell-function-in-diabetes
#5
C Guglielmi, R Del Toro, A Lauria, A R Maurizi, A Cappelli, S Angeletti, J M Lachin, P Pozzilli
BACKGROUND: The aim of the study was to investigate the different β cell responses after a glucagon stimulation test (GST) versus mixed meal tolerance test (MMTT). METHODS: We carried out GST and MMTT in 10 healthy people (aged 25-40 yrs) and measured C-peptide, gastric inhibitory peptide (GIP) and glucagon like peptide 1 (GLP1) at different time points after the administration of 1 mg i.v. glucagon for GST or a liquid mixed meal for MMTT. RESULTS: The GST stimulated C-peptide showed a mean increase of 147...
March 31, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28371132/characteristics-of-the-pre-diabetic-period-in-children-with-high-risk-of-type-1-diabetes-recruited-from-the-general-swedish-population-the-abis-study
#6
Linda Åkerman, Johnny Ludvigsson, Ulrica Swartling, Rosaura Casas
BACKGROUND: There is a need for increased understanding of the pre-diabetic period in individuals with high risk of type 1 diabetes (T1D) from the general population. METHODS: High-risk children (n = 21) positive for multiple islet autoantibodies were identified by autoantibody screening within the ABIS (All Babies in Southeast Sweden) study. The children and their parents were enrolled in a 2-year prospective follow-up study aiming to characterize the pre-diabetic period...
March 31, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28322014/carbohydrate-intake-during-early-pregnancy-is-inversely-associated-with-abnormal-glucose-challenge-test-results-in-japanese-pregnant-women
#7
Ryoko Tajima, Yoko Yachi, Yasuhiro Tanaka, Yui Anasako Kawasaki, Izumi Nishibata, Ayumi Sugawara Hirose, Chika Horikawa, Satoru Kodama, Kaoruko Iida, Hirohito Sone
BACKGROUND: In East Asian countries, which have a high prevalence of underweight individuals, there is little information about the association between dietary factors and abnormal glucose tolerance during pregnancy. We examined the association between carbohydrate intake and moderately abnormal glucose tolerance in Japanese pregnant women. METHODS: We conducted a prospective study on 325 Japanese pregnant women without a diagnosis of diabetes mellitus prior to pregnancy...
March 20, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28303626/lixisenatide-as-add-on-treatment-among-patients-with-different-%C3%AE-cell-function-levels-as-assessed-by-homa-%C3%AE-index
#8
Riccardo C Bonadonna, Lawrence Blonde, Mikhail Antsiferov, Rachele Berria, Pierre Gourdy, Mensud Hatunic, Viswanathan Mohan, Michael Horowitz
BACKGROUND: The effect of lixisenatide - a prandial once-daily glucagon-like peptide-1 receptor agonist - on glycaemic control in patients with inadequately controlled type 2 diabetes (T2DM), stratified by baseline β-cell function was assessed. METHODS: The 24-week GetGoal-M, -P and -S trials evaluated the efficacy and safety of lixisenatide in combination with oral antidiabetic agents. This post hoc analysis used data from patients receiving lixisenatide in these trials, divided into matched cohorts by propensity scoring and stratified according to baseline homeostasis model assessment of β-cell function (HOMA-β) index levels (high HOMA-β: > median HOMA-β [28...
March 17, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28303682/ultrastructural-alterations-of-pancreatic-beta-cells-in-human-diabetes-mellitus
#9
Matilde Masini, Luisa Martino, Lorella Marselli, Marco Bugliani, Ugo Boggi, Franco Filipponi, Piero Marchetti, Vincenzo De Tata
BACKGROUND: Both types of diabetes are characterized by beta-cell failure and death, leading to insulin insufficiency. Very limited information is currently available about the ultrastructural alterations of beta cells in human diabetes. Our aim was to provide a comprehensive ultrastructural analysis of human pancreatic islets in type 1 (T1D) and type 2 (T2D) diabetic patients. METHODS: We performed a morphometric electron microscopy evaluation of beta cells obtained from the pancreas of 8 nondiabetic (ND), 5 T1D, and 8 T2D organ donors...
March 16, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28303637/plasma-sfrp5-levels-correlate-with-determinants-of-the-metabolic-syndrome-in-chinese-adults
#10
Qiuyan Xu, Hongyan Wang, Yang Li, Jinzhi Wang, Yerui Lai, Lin Gao, Lu Lei, Gangyi Yang, Xin Liao, Xia Fang, Hua Liu, Ling Li
BACKGROUND: Secreted frizzled-related protein-5 (Sfrp5) is a novel adipokine, and it has been found to link insulin resistance with diabetes. Animal studies have revealed the role of Sfrp5 in regulating lipid and glucose metabolism. The objective of this study was to investigate the relationship between Sfrp5 and the metabolic syndrome (MetS) in a cross-sectional study. METHODS: We conducted a series of cross-sectional studies of Chinese population including 194 control participants and 90 MetS patients...
March 16, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28303635/incident-microalbuminuria-and-complement-factor-mannan-binding-lectin-associated-protein-19-in-people-with-newly-diagnosed-type-1-diabetes
#11
J A Østergaard, S Thiel, I T Hoffmann-Petersen, P Hovind, H-H Parving, L Tarnow, P Rossing, T K Hansen
BACKGROUND: Evidence links the lectin pathway of complement activation to diabetic kidney disease. Upon carbohydrate-recognition by pattern-recognition molecules, eg, mannan-binding lectin (MBL), the MBL-associated serine protease (MASP-2) is activated and initiates the complement cascade. The MASP2 gene encodes MASP-2 and the alternative splice product MBL-associated protein 19 (MAp19). Both MAp19 and MASP-2 circulate in complex with MBL. We tested the hypothesis that MAp19 and MASP-2 concentrations predict the risk of incident microalbuminuria...
March 16, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28258654/novel-oral-anticoagulants-in-patients-with-atrial-fibrillation-and-diabetes-good-or-excellent
#12
Aviv A Shaul, Alon Eisen
No abstract text is available yet for this article.
March 4, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28249105/advanced-glycation-end-products-ages-and-associations-with-cardio-metabolic-lifestyle-and-dietary-factors-in-a-general-population-the-nqplus-study
#13
Nadia Botros, Diewertje Sluik, Robert P van Waateringe, Jeanne H M de Vries, Anouk Geelen, Edith J M Feskens
BACKGROUND: Advanced glycation end-products are a heterogeneous group of molecules that are formed during reactions between reducing sugars and proteins. Advanced glycation end-products are thought to play a role in several diseases, including diabetes mellitus and can be measured non-invasively using skin autofluorescence (AF). The aim of this cross-sectional study was to investigate associations between skin AF and cardio-metabolic, lifestyle, and dietary factors within a general population...
March 1, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28224756/type-2-diabetes-after-gestational-diabetes-mellitus-in-south-asian-women-in-the-united-states
#14
Meghana D Gadgil, Reena Oza-Frank, Namratha R Kandula, Alka M Kanaya
AIMS: Gestational diabetes mellitus (GDM) is a major risk factor for type 2 diabetes. The incidence of both GDM and type 2 diabetes is exceedingly high in South Asian populations. However, the risk of type 2 diabetes after GDM in South Asian women in the United States is unknown. METHODS: South Asians aged 40 to 84 years without known cardiovascular disease were enrolled in a community-based cohort called Mediators of Atherosclerosis in South Asians Living in America study...
February 22, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28198147/intrahepatic-fat-abdominal-adipose-tissues-and-metabolic-state-magnetic-resonance-imaging-study
#15
Anat Yaskolka Meir, Lilac Tene, Noa Cohen, Ilan Shelef, Dan Schwarzfuchs, Yftach Gepner, Hila Zelicha, Michal Rein, Nitzan Bril, Dana Serfaty, Shira Kenigsbuch, Yoash Chassidim, Benjamin Sarusy, Dror Dicker, Joachim Thiery, Uta Ceglarek, Michael Stumvoll, Matthias Blüher, Meir J Stampfer, Assaf Rudich, Iris Shai
BACKGROUND: Intrahepatic-fat (IHF) is best known to associate with waist circumference (WC) and visceral-adipose-tissue (VAT), but its relation to abdominal subcutaneous-adipose tissue (SAT) is controversial. While IHF > 5% dichotomously defines fatty liver, %IHF is rarely considered as a continuous variable that includes the normal range. In this study, we aimed to evaluate %IHF association with abdominal fat sub-depots, pancreatic and renal-sinus fats. METHODS: We evaluated %IHF, abdominal fat sub-depots, %pancreatic and renal-sinus fats, among individuals with moderate abdominal obesity, using 3-T magnetic resonance imaging (MRI)...
February 14, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28198145/secular-and-race-ethnic-trends-in-glycemic-outcomes-by-bmi-in-us-adults-the-role-of-waist-circumference
#16
Sandra S Albrecht, Elizabeth Mayer-Davis, Barry M Popkin
BACKGROUND: For the same BMI level, waist circumference (WC) is higher in more recent years. How this impacts diabetes and pre-diabetes prevalence in the US and for different race/ethnic groups is unknown. We examined prevalence differences diabetes and pre-diabetes by BMI over time, investigated whether estimates were attenuated after adjusting for WC, and evaluated implications of these patterns on race/ethnic disparities in glycemic outcomes. METHODS: Data came from 12,614 participants aged 20-74 years from the National Health and Nutrition Examination Surveys (1988-1994; 2007-2012)...
February 14, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28198081/latent-autoimmune-diabetes-in-adults-lada-in-asian-and-european-populations
#17
REVIEW
Alok Kumar, Alberto de Leiva
Diabetes mellitus is a chronic disorder caused by relative or absolute insulin deficiency and characterized by chronic hyperglycaemia. It is expected that by year 2025, 80% of all type 2 diabetic patients will be living in developing or low- and middle-income countries. Among Asians, there has been an overall increase in abdominal obesity; however, the risk of diabetes in these populations starts at much lower body mass index as compared to Caucasians. A significant proportion of diabetic patients with adult-onset, initially nonrequiring insulin treatment, have diabetes-associated autoantibodies in their sera...
February 14, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28029216/safety-and-efficacy-of-nonvitamin-k-antagonist-oral-anticoagulants-versus-warfarin-in-diabetic-patients-with-atrial-fibrillation-a-study-level-meta-analysis-of-phase-iii-randomized-trials
#18
REVIEW
Giuseppe Patti, Giuseppe Di Gioia, Ilaria Cavallari, Antonio Nenna
In patients with atrial fibrillation (AF), the safety and efficacy of nonvitamin K antagonist oral anticoagulants (NOACs) vs warfarin according to diabetes mellitus (DM) status are not completely characterized. We performed a meta-analysis to clarify whether in these patients the strategy of oral anticoagulation should be tailored to diabetes status. In this study-level meta-analysis, we included 4 randomized phase III trials comparing NOACs and warfarin in patients with nonvalvular AF; a total of 18 134 patients with DM and 40 454 without DM were overall considered...
March 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/27792855/minor-amputation-does-not-negatively-affect-health-related-quality-of-life-as-compared-with-conservative-treatment-in-patients-with-a-diabetic-foot-ulcer-an-observational-study
#19
K Pickwell, V Siersma, M Kars, J Apelqvist, K Bakker, M Edmonds, P Holstein, A Jirkovská, E B Jude, D Mauricio, A Piaggesi, H Reike, M Spraul, L Uccioli, V Urbancic, K van Acker, J van Baal, N Schaper
BACKGROUND: Health-related quality of life (HRQoL) is poor in patients with persistent diabetic foot ulcers and poor HRQoL predicts worse outcomes in these patients. Amputation is often considered a treatment failure, which is why conservative treatment is generally preferred over amputation. However, it is unclear whether minor amputation negatively affects HRQoL compared with conservative treatment in patients with diabetic foot ulcers. METHODS: In the cohort of the multicenter, prospective, observational Eurodiale study, we determined difference in change of HRQoL measured by EQ-5D between patients with a diabetic foot ulcers that healed after conservative treatment (n = 676) and after minor amputation (n = 145)...
March 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/27606888/a-global-study-of-the-unmet-need-for-glycemic-control-and-predictor-factors-among-patients-with-type-2-diabetes-mellitus-who-have-achieved-optimal-fasting-plasma-glucose-control-on-basal-insulin
#20
Denis Raccah, Engels Chou, Stephen Colagiuri, Zsolt Gaàl, Fernando Lavalle, Ashot Mkrtumyan, Elena Nikonova, Nikolaos Tentolouris, Josep Vidal, Melanie Davies
BACKGROUND: This study used data from different sources to identify the extent of the unmet need for postprandial glycemic control in patients with type 2 diabetes mellitus (T2DM) after the initiation of basal insulin therapy in Europe, Asia Pacific, the United States, and Latin America. METHODS: Different levels of evidence were used as available for each country/region, with data extracted from seven randomized controlled trials (RCTs), three clinical trial registries (CTRs), and three electronic medical record (EMR) databases...
March 2017: Diabetes/metabolism Research and Reviews
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