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Diabetes/metabolism Research and Reviews

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https://www.readbyqxmd.com/read/29351716/effect-of-metformin-on-glycemic-control-in-patients-with-type-1-diabetes-a-meta-analysis-of-randomized-controlled-trials
#1
Haiyang Meng, Ailing Zhang, Yan Liang, Jie Hao, Xiaojian Zhang, Jingli Lu
BACKGROUND: For T1D patients, adding metformin to insulin therapies is thought to improve blood glucose levels, but current evidence does not support this clinical benefit. Additional data from large clinical trials are now available; therefore, we conducted a meta-analysis of studies on assessing the efficacy and adverse effects of metformin. METHODS: We searched the MEDLINE, EMBASE and Cochrane Library databases for data from randomized controlled trials (RCTs)...
January 19, 2018: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29334697/sepsis-induced-activation-of-endogenous-glp-1-system-is-enhanced-in-type-2-diabetes
#2
Sivan H Perl, Olga Bloch, Dana Zelnic-Yuval, Itamar Love, Lior Mendel-Cohen, Hadar Flor, Micha J Rapoport
BACKGROUND: High levels of circulating GLP-1 are associated with severity of sepsis in critically ill non-diabetic patients. Whether type 2 diabetes (T2D) patients display different activation of the endogenous GLP-1 system during sepsis and whether it is affected by diabetes related metabolic parameters is not known. METHODS: Serum levels of GLP-1 (total and active forms) and its inhibitor enzyme sDPP-4 were determined by ELISA on admission and after 2-4 days in 37 sepsis patients with (n=13) and without T2D (n=24) and compared to normal healthy controls (n=25)...
January 15, 2018: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29320602/when-metformin-is-not-enough-pros-and-cons-of-sglt2-and-dpp-4-inhibitors-as-a-second-line-therapy
#3
REVIEW
Angelo Avogaro, Elías Delgado, Ildiko Lingvay
The newer oral therapies for type 2 diabetes (T2DM); dipeptidyl peptidase-4 (DPP-4) inhibitors and sodium glucose cotransporter 2 (SGLT2) inhibitors have advantages over older agents. DPP-4 inhibitors are weight neutral, and have few adverse effects. SGLT2 inhibitors have additional benefits; weight loss, blood pressure reduction, cardiovascular risk reduction, and renoprotective effects. SGLT2 inhibitors, have increased risk of urogenital infections and possible risk of "euglycaemic" diabetic ketoacidosis...
January 10, 2018: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29314572/high-fat-diet-induced-tcf7l2-promoter-methylation-impairs-%C3%AE-cell-function-in-mouse-pancreatic-islets
#4
Yun Hu, Ping Shi, Ke He, Yun-Qing Zhu, Fan Yang, Min Yang, Bang-Shun He, Xiao-Ming Mao
BACKGROUND: The TCF7L2 (transcription factor 7 like 2) gene is strongly associated with type 2 diabetes (T2D) risk. However, many people without the TCF7L2 at-risk allele develop T2D. The aim of this study was to investigate altered Tcf7l2 DNA methylation and gene expression caused by high-fat diets (HFDs). METHODS: C57BL/6 mice were fed either a HFD or normal diet for 8 weeks and intraperitoneal glucose tolerance tests were performed. Pancreatic islets were sorted for bisulfite sequencing PCR to determine DNA methylation status...
January 4, 2018: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29314667/clinical-characteristics-of-type-2-diabetes-patients-with-discordance-between-hba1c-and-fasting-plasma-glucose-in-the-real-world-an-analysis-of-the-orbit-study
#5
Hua Shu, Juming Lu, Puhong Zhang, Dongshan Zhu, Xian Li, Jiachao Ji, Fang Zhao, Linong Ji
BACKGROUND: We aimed to determine the clinical characteristics of type 2 diabetes patients on basal insulin therapy with inadequate glucose control due to discordance between glycated hemoglobin (HbA1c) and fasting plasma glucose (FPG) in the real world. METHODS: This was a retrospective analysis of data from the ORBIT study in China. Clinical characteristics of patients with discordance between HbA1c and FPG at baseline and at the end of 6 months of follow-up were analyzed using multinomial logistic regression in 4 study groups devided by HbA1c and FPG...
January 3, 2018: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29281762/body-mass-index-and-mortality-in-patients-with-and-without-diabetes-mellitus
#6
Amit Akirov, Tzipora Shochat, Hiba Masri-Iraqi, Dror Dicker, Talia Diker-Cohen, Ilan Shimon
OBJECTIVE: Investigate the association between BMI, length of stay (LOS) and mortality in hospitalized patients with and without diabetes mellitus (DM). METHODS: Historical prospectively collected data of adult patients hospitalized between 2011 and 2013. BMI was calculated according to measurement or self-report on admission, and classified as follows: underweight (<18.5), normal weight (18.5-24.9), overweight (25-29.9), obesity (30-34.9) and severely obese (≥35)...
December 27, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29271563/is-metformin-poised-for-a-second-career-as-an-antimicrobial
#7
REVIEW
Faiza Malik, Syed Faizan Mehdi, Haroon Ali, Priya Patel, Anam Basharat, Amrat Kumar, Fnu Ashok, Joanna Stein, Wunnie Brima, Prashant Malhotra, Jesse Roth
BACKGROUND: Metformin, a widely used anti-hyperglycemic, has a good safety profile, reasonably manageable side-effects, is inexpensive and causes a desirable amount of weight loss. In four studies of patients with tuberculosis (one prospective and three retrospective), metformin administration resulted in better outcomes. In mice with several models of endotoxemia, metformin diminished levels of pro-inflammatory cytokines and improved survival. Laboratory studies showed effectiveness of the drug on multiple pathogens, including Trichinella spiralis, Staphylococcus aureus, Pseudomonas aeruginosa, Hepatitis B virus, Hepatitis C virus and human immunodeficiency virus...
December 22, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29271560/calculating-individualized-glycaemic-targets-using-an-algorithm-based-on-expert-worldwide-diabetologists-implications-in-real-life-clinical-practice
#8
Fernando Alvarez Guisasola, Ana M Cebrián-Cuenca, Xavier Cos, Manuel Ruiz-Quintero, Jose M Millaruelo, Avivit Cahn, Itamar Raz, Domingo Orozco-Beltrán
OBJECTIVE: The aim of this study was to assess the clinical implications of calculating an individualized HbA1c target using a recently published algorithm in a real-life clinical setting. METHODS: General practitioners (GPs) from the Spanish Society of Family Medicine Diabetes Expert Group were invited to participate in the study. Each GP selected a random sample of patients with diabetes from his/her practice and submitted their demographic and clinical data for analysis...
December 22, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29271076/the-association-of-low-muscle-mass-with-soluble-receptor-for-advanced-glycation-end-products-srage-the-korean-sarcopenic-obesity-study-ksos
#9
Tae Nyun Kim, Man Sik Park, Eun Joo Lee, Hye Soo Chung, Hye Jin Yoo, Hyun Joo Kang, Wook Song, Sei Hyun Baik, Kyung Mook Choi
BACKGROUND: Advanced glycation end products (AGEs) are accumulated with aging in various tissues of humans. The soluble receptor for AGEs (sRAGE) exerts a protective role against the development of aging-related chronic disorders by neutralizing the action of AGEs. We investigated the implication of sRAGE on low muscle mass in Asian men and women. METHODS: This cross-sectional study included a 390-subject, non-diabetic subcohort recruited within the framework of the Korean Sarcopenic Obesity Study, an ongoing prospective cohort study...
December 22, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29232497/evaluation-of-olfaction-and-taste-function-in-type-2-diabetic-patients-with-and-without-peripheral-neuropathy
#10
Semih Yazla, Süay Özmen, Sinem Kıyıcı, Demet Yıldız, Mehmet Haksever, Sündüz Gencay
AIMS: Olfaction and gustation in patients with diabetes mellitus (DM) have great significance on quality of life and their impairment may result in possible hazards. A limited number of studies have been performed to determine the alteration of both gustatory and olfactory function in type 2 diabetic patients with diabetic peripheral neuropathy (DPN). The aim of this study was to determine whether type 2 diabetic patients, with and without DPN, exhibit major olfactory and gustatory dysfunction using validated and dependable techniques...
December 12, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29230944/improved-insulin-sensitivity-appears-to-remain-for-a-mean-of-four-years-following-islet-cell-transplant-for-type-1-diabetes
#11
Brett Rydzon, Rebecca S Monson, Jose Oberholzer, Krista A Varady, Melena D Bellin, Kirstie K Danielson
BACKGROUND: Impaired insulin sensitivity (IS) predicts complications and mortality in type 1 diabetes (T1D). IS improves shortly after islet cell transplant for type 1 diabetes, yet long-term changes in IS, and associated factors such as patient characteristics, transplant factors, clinical management, and IS-related biomarkers are unknown. METHODS: Up to nine years (mean four) of longitudinal data were available on 22 adults (18 female) with T1D who received 1-3 transplants in Phase 1/2 or 3 clinical trials (2004-2014)...
December 12, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29193662/the-effects-of-probiotic-administration-on-wound-healing-and-metabolic-status-in-patients-with-diabetic-foot-ulcer-a-randomized-double-blind-placebo-controlled-trial
#12
Sima Mohseni, Masomeh Bayani, Fereshteh Bahmani, Maryam Tajabadi-Ebrahimi, Mohammad Ali Bayani, Parvaneh Jafari, Zatollah Asemi
BACKGROUND: This study was conducted to evaluate the effects of probiotic supplementation on wound healing and metabolic status in subjects with diabetic foot ulcer (DFU). METHODS: This randomized, double-blind, placebo-controlled trial was conducted among 60 subjects (aged 40-85 years old) with grade 3 DFU. Individuals were randomly divided into two groups (30 subjects each group) to receive either probiotic or placebo daily for 12 weeks. RESULTS: After the 12-week intervention, compared with the placebo, probiotic supplementation led to significant reductions in ulcer length (-1...
November 28, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29172025/vitamin-d-ratio-and-glycemic-control-in-individuals-with-type-2-diabetes-mellitus-a-systematic-review
#13
REVIEW
Ramara Kadija Fonseca Santos, Paula Nascimento Brandão-Lima, Raissa Maria Dumas Delatore Tete, Analícia Rocha Santos Freire, Liliane Viana Pires
BACKGROUND: Several studies have suggested the role of vitamin D in glycemic metabolism and its potential as adjuvant treatment of type 2 diabetes mellitus. Thus, this review discusses the role of vitamin D in the glycemic control of individuals with type 2 diabetes mellitus and evaluates the effect of vitamin D supplementation on glycemic markers in this population. METHODS: Literature searches were performed in the BIREME, LILACS, and PubMed databases using the Medical Subject Headings and words related to vitamin D, type 2 diabetes mellitus, and glycemic control...
November 24, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29172021/early-onset-type-2-diabetes-age-gradient-in-clinical-and-behavioural-risk-factors-in-5115-persons-with-newly-diagnosed-type-2-diabetes-results-from-the-dd2-study
#14
A Bo, R W Thomsen, J S Nielsen, S K Nicolaisen, H Beck-Nielsen, J Rungby, H T Sørensen, T K Hansen, J Søndergaard, S Friborg, T Lauritzen, H T Maindal
AIM: To examine the association between early onset of type 2 diabetes (DM) and clinical and behavioural risk factors for later diabetes complications. METHODS: We conducted a cross-sectional study of 5115 persons with incident type 2 DM enrolled during 2010-2015 in the Danish Centre for Strategic Research in Type 2 Diabetes-cohort. We compared risk factors at time of diagnosis among those diagnosed at ≤45 years (early-onset) with diagnosis age 46-55, 56-65 (average-onset = reference), 66-75, and >75 years (late-onset)...
November 24, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29156090/a-case-control-study-the-association-of-serum-paraoxonase-1-activity-and-concentration-with-the-development-of-type-2-diabetes-mellitus
#15
J Allen Crow, Edward C Meek, Robert W Wills, Janice E Chambers
BACKGROUND: A longitudinal study assessed serum paraoxonase 1 (PON1) activity and concentration as affected by age and as associated with the development of type 2 diabetes (T2D). PON1's recently established physiological function is the hydrolysis of lipolactones in oxidized LDL particles. METHODS: Serum samples and clinical data collected and stored at different time points over a 20 year interval in the Air Force Health Study were analyzed. PON1 activity and concentration and C-reactive protein (CRP) concentration in samples from the same individuals 20 years apart were compared using a paired t test (n=159)...
November 20, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29144029/neck-circumference-a-valuable-anthropometric-measurement-to-detect-metabolic-syndrome-among-different-age-groups-in-china
#16
Ting Cui, Ban-Huao Yan, Zhan Liu, Hui Yang, Michael Gyan, Yu-Xia Ma
OBJECTIVES: The aim of this study was to investigate the correlation between neck circumference (NC) and metabolic syndrome (MS) in Chinese residents and to explore the cut-off points of NC for MS in different age groups. METHODS: In all, 4227 Chinese adults (18-90 years) were enrolled in the study and divided into three subgroups (young, middle-aged and elderly) according to their ages. The compared data for the subjects included anthropometric indicators and biochemical detection indices...
November 16, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29144024/epidemiology-of-type-1-diabetes-in-polish-children-a-multicentre-cohort-study
#17
Mieczysław Szalecki, Marta Wysocka-Mincewicz, Anna Ramotowska, Artur Mazur, Lucyna Lisowicz, Iwona Ben-Skowronek, Joanna Sieniawska, Bożena Klonowska, Dorota Charemska, Jolanta Nawrotek, Irena Jałowiec, Artur Bossowski, Milena Jamiołkowska, Beata Pyrżak, Grażyna Miszkurka, Agnieszka Szypowska
BACKGROUND: The incidence of childhood Type-1 diabetes (T1D) varies greatly between populations and the estimates and/or predictions of the rates would aid in adequate planning of health care resources. The study's aim was to assess the incidence of T1D in the paediatric population of eastern and central Poland. METHODS: In this cohort study covering the period from January 2010 to December 2014 data were collected for children and adolescents below 18 years of age with newly diagnosed T1D, living in eastern and central Poland...
November 16, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29135074/effects-of-alcohol-on-plasma-glucose-and-prevention-of-alcohol-induced-hypoglycemia-in-type-1-diabetes-a-systematic-review-with-grade
#18
REVIEW
R Tetzschner, K Nørgaard, A Ranjan
BACKGROUND: Since ethanol is thought to be a risk factor for severe hypoglycemia, patients with type 1 diabetes (T1D) are recommended to limit ethanol intake. However, little is known on how ethanol affects plasma glucose and how ethanol-induced hypoglycemia can be prevented. In this study, we systematically reviewed the literature for ethanol effects on plasma glucose and for prevention strategies on ethanol-induced hypoglycemia. METHODS: Electronic searches on PubMed and Google were conducted in February 2017...
November 14, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29135069/impaired-secretion-of-active-glp-1-in-patients-with-hypertriglyceridaemia-a-novel-lipotoxicity-paradigm
#19
Xiangxiang Wang, Jia Liu, Chaolin Li, Meng Zhao, Lu Liu, Qingbo Guan, Haiqing Zhang, Xu Zhang, Ling Gao, Jiajun Zhao, Yongfeng Song
AIM: Lipotoxicity plays an important role in the pathogenesis of β-cell dysfunction. Glucagon-like peptide-1 (GLP-1) is an incretin hormone that exerts beneficial effects on the number and function of islet β cells. However, the effect of lipotoxicity on GLP-1 secretion is still unknown. METHODS: Twenty-five patients who were newly diagnosed with diabetes were recruited from 400 subjects based on 75 g Oral Glucose Tolerance Test (OGTT). Patients were divided into diabetes (DM) and DM combined with hypertriglyceridaemia (DM+HTG) groups according to their serum triglyceride (TG) levels...
November 14, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29125710/thiazolidinedione-therapy-and-breast-cancer-risk-in-diabetic-women-a-systematic-review-and-meta-analysis
#20
REVIEW
Rui Du, Lin Lin, Di Cheng, Yu Xu, Min Xu, Yuhong Chen, Weiqing Wang, Yufang Bi, Donghui Li, Jieli Lu
BACKGROUND: Rising experimental evidence suggests that thiazolidinediones (TZDs) exert a protective effect on breast cancer. However, studies concerning this issue were inconsistent and limited. Hence, we performed a meta-analysis with data from currently available studies to evaluate the effect of TZDs on breast cancer risk among diabetic women. METHODS: We comprehensively searched for all pertinent studies addressing TZDs use and breast cancer risk published before January 1, 2016 in PubMed, Clinical Trials and Cochrane library...
November 10, 2017: Diabetes/metabolism Research and Reviews
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