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Diabetes/metabolism Research and Reviews

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https://www.readbyqxmd.com/read/30635961/high-intensity-breastfeeding-improves-insulin-sensitivity-during-early-postpartum-period-in-obese-women-with-gestational-diabetes
#1
Ichiro Yasuhi, Hiroshi Yamashita, Kazuhisa Maeda, Makoto Nomiyama, Tomoya Mizunoe, Katsuhiko Tada, Moe Yorozu, Masanobu Ogawa, Takashi Kodama, Ken Yamaguchi, Naofumi Okura, Kosuke Kawakami, Yuka Maekawa, Kimikazu Hayashi
AIM: TO INVESTIGATE WHETHER HIGH-INTENSITY BREASTFEEDING (HIB) REDUCES INSULIN RESISTANCE DURING EARLY POSTPARTUM PERIOD IN WOMEN WITH GESTATIONAL DIABETES (GDM), INDEPENDENT OF POSTPARTUM WEIGHT CHANGE (PWC).: MATERIALS AND METHODS: In this multicenter prospective study, we included Japanese women with GDM who underwent a 75-g oral glucose tolerance test (OGTT) during early postpartum. We measured plasma insulin during OGTT to obtain a homeostasis model of assessment of insulin resistance (HOMA-IR)...
January 12, 2019: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/30614187/association-of-high-circulating-testosterone-with-increased-glycemic-variability-in-patients-with-type-2-diabetes-a-cross-sectional-study-in-china
#2
Bo Ding, Rui Sun, Xiao-Fang Zhai, Ting-Ting Lu, Liang Cheng, Feng-Fei Li, Yun Hu, Jian-Hua Ma
BACKGROUND: Testosterone affects insulin resistance, but the effect of testosterone treatment on type 2 diabetes (T2D) remains controversial. We aimed to investigate the association between circulating total testosterone (TT) and glycemic variability using continuous glucose monitoring (CGM) in patients with T2D. MATERIALS AND METHODS: A total of 248 men with T2D were finally enrolled in the study. Clinical characteristics and plasma for glycated hemoglobin (HbA1c) and C-peptide assessment were collected...
January 6, 2019: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/30614185/six-year-follow-up-study-on-the-association-between-white-blood-cell-count-and-fasting-blood-glucose-level-in-chinese-adults-a-community-based-health-examination-survey-dmrr-18-res-399
#3
Xiu Zang, Xiangyu Meng, Yun Wang, Xiao Jin, Tingting Wu, Xuekui Liu, Houfa Geng, Wei Xu, Yu Wang, Fei Teng, Qinqin Qiu, Manqing Yang, Jun Liang
OBJECTIVE: This study aimed to explore the relationship between white blood cell count (WBC) in the community adult population with fasting blood glucose (FBG) levels and the cumulative risk of impaired fasting glucose (IFG) regulation at 6 years. Moreover, it aimed to explore the relationship between WBC counts and IFG risks. METHODS: A community-based health examination survey was conducted among individuals who were randomly selected from 1,300 residents living in China in 2010-2016...
January 6, 2019: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/30604504/cardiovascular-effects-of-sglt-2-inhibitors-what-we-have-learned-from-cardiovascular-outcome-trials-and-what-we-still-need-to-understand
#4
Ilaria Cavallari, Ernesto Maddaloni
The recent results of the DECLARE-TIMI 58 trial forces a profound reflection about the cardiovascular protection conferred by SGLT-2 inhibitors. DECLARE-TIMI 58, the largest cardiovascular outcome trial in diabetes, failed to show a significant reduction in the risk of major cardiovascular events (MACE) conferred by dapagliflozin compared to placebo. However, a lower rate of hospitalization for heart failure was reported. While the lack of benefits on MACE may seem in contrast with the results of previous SGLT-2 inhibitors cardiovascular outcome trials, DECLARE clearly delineates the real cardiovascular effects of SGLT-2 inhibitors, which mainly tackle heart failure...
January 3, 2019: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/30604460/angiotensin-converting-enzyme-2-inhibits-endoplasmic-reticulum-stress-associated-pathway-to-preserve-non-alcoholic-fatty-liver-disease
#5
Xi Cao, Li-Ni Song, Yi-Chen Zhang, Qi Li, Ting-Ting Shi, Fang-Yuan Yang, Ming-Xia Yuan, Zhong Xin, Jin-Kui Yang
BACKGROUND: Previous works indicated that the stress on the endoplasmic reticulum (ER) affected non-alcoholic fatty liver disease (NAFLD). However, there is no clear evident on the effect of the regulation of ER stress by ACE2 on the prevention of NAFLD. METHODS: HepG2 cells were treated with Tg (thapsigargin) or PA (palmitic acid). We analyzed ACE2 expression using Western-blotting analyses. ER stress-related proteins were detected in ACE2 knockout mice and Ad-ACE2-treated db/db mice by immunofluorescence or Western-blotting analyses...
January 2, 2019: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/30600922/association-of-diabetes-treatment-with-long-term-glycemic-patterns-in-patients-with-type-2-diabetes-mellitus-a-prospective-cohort-study
#6
Miyang Luo, Chuen Seng Tan, Wei Yen Lim, Kee Seng Chia, Wern Ee Tang, E Shyong Tai, Kavita Venkataraman
AIM: This study aimed to analyze diabetes treatment and treatment changes in association with long-term glycemic patterns in an Asian population with diabetes. MATERIALS AND METHODS: This was a prospective cohort study of 6,218 patients with type 2 diabetes managed in public primary care clinics in Singapore. Clinical data from 2011 to 2016 were extracted from electronic medical records, including serial HbA1c measurements and dispensed antidiabetic medication records...
January 2, 2019: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/30600581/the-metabolic-syndrome-and-its-components-are-differentially-associated-with-chronic-diseases-in-a-high-risk-population-of-350-000-adults-a-cross-sectional-study
#7
HanaꞋa Rayyan Assi, Arnona Ziv, Rachel Dankner
AIMS: We compared strengths of associations conferred by the metabolic syndrome (MetS) and its components across four chronic disease categories (cancer, cardiovascular diseases-CVD, chronic kidney disease-CKD and chronic obstructive pulmonary disease-COPD) in a community-dwelling high-risk population. METHODS: This is a cross-sectional analysis of Israeli adults insured in a single health maintenance organization during 2010-2013 and having ≥2 MetS components (hypertension, dysglycemia, low high-density lipoprotein level, high plasma triglyceride level and obesity)...
January 1, 2019: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/30578707/higher-pulse-pressure-predicts-initiation-of-dialysis-in-japanese-patients-with-diabetes-analysis-using-a-nationwide-claim-database
#8
Taeko Osawa, Kazuya Fujihara, Mayuko Harada, Masahiko Yamamoto, Masahiro Ishizawa, Hiroshi Suzuki, Hajime Ishiguro, Yasuhiro Matsubayashi, Hiroyasu Seida, Nauta Yamanaka, Shiro Tanaka, Hitoshi Shimano, Satoru Kodama, Hirohito Sone
AIMS: To determine incidence and predictors of starting dialysis in patients with diabetes emphasizing blood pressure variables. METHODS: A nationwide database with claim data on 18,935 people (15,789 men and 3,146 women) with diabetes mellitus aged 19-72 y in Japan was used to elucidate predictors for starting dialysis. Initiation of dialysis was determined from claims using ICD-10 codes and medical procedures. Using multivariate Cox modeling, interactions between glycaemic and blood pressure values were determined...
December 22, 2018: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/30575290/predicting-ulcer-free-survival-using-the-discriminative-value-of-screening-test-locations
#9
Willem D Rinkel, Mark J W van der Oest, Don A Dijkstra, Manuel Castro Cabezas, J Henk Coert
AIMS: Current guidelines recommend screening the feet of diabetic subjects with a 10 g monofilament or tuning fork. We investigated which tests and locations on the feet have the best predictive value regarding one-year ulcer-free survival, in diabetic subjects participating in the prospective Rotterdam Diabetic Foot Study. METHODS: Decision tree analysis was used to predict ulcer free survival, based on responses from individual test locations (monofilaments on 10 sites, vibration sense was tested on both halluces and medial malleoli)...
December 21, 2018: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/30557902/apolipoprotein-ciii-and-diabetes-is-there-a-link
#10
REVIEW
Eliza Christopoulou, Vasilios Tsimihodimos, Theodosios Filippatos, Moses Elisaf
Apolipoprotein CIII (ApoCIII), a small protein that resides on the surface of lipoprotein particles, is a key regulator of triglyceride metabolism. The inhibition of lipoprotein lipase (LPL), the increased assembly and secretion of very low-density lipoproteins (VLDL) and the decreased reuptake of triglyceride-rich lipoproteins (TRLs) by the liver are mechanisms associating elevated serum ApoCIII levels and hypertriglyceridemia. ApoCIII concentration is high in individuals with diabetes mellitus indicating a possible positive correlation with impairment of glucose metabolism...
December 17, 2018: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/30549421/elevated-circulating-cathepsin-s-levels-are-associated-with-metabolic-syndrome-in-overweight-and-obese-individuals
#11
Lili Chen, Bin Lu, Yehong Yang, Weiwei Zhang, Xuanchun Wang, Houguang Zhou, Jie Wen, Zhen Yang, Renming Hu
OBJECTIVE: Cathepsin S is highly expressed in subcutaneous and visceral adipose tissue. Cathepsin S correlates with central obesity and contributes to the formation and progression of atherosclerosis. Here, we sought to evaluate the association of serum cathepsin S with metabolic syndrome (MS) in overweight and obese Chinese adults. METHODS: We evaluated serum cathepsin S levels in a cross-sectional sample of 781 overweight and obese Chinese adults by ELISA. Glucose, insulin, lipid profile, inflammatory markers, and adipokines were also measured...
December 14, 2018: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/30548993/peripheral-fat-distribution-versus-waist-circumference-in-metabolic-syndrome-for-predicting-mortality
#12
Chen-Jung Wu, Tung-Wei Kao, Yuan-Yuei Chen, Hui-Fang Yang, Wei-Liang Chen
Objective To elucidate whether the PF-combined definition of metabolic syndrome (MetS) would show a better predictive ability for cause-specific mortality than the common MetS. Methods The data were derived from the National Health and Nutrition Examination Survey from 1999 through 2002. We investigated three types of MetS including WCMetS, PFMetS, and PF-combined definition MetS. The main outcome was to evaluate the predictive ability of the newly defined MetS for time to cause-specific mortality. The secondary outcomes were the relationships between the PF percentage and C-reactive protein (CRP) and homeostasis model assessment of insulin resistance (HOMA-IR) to clarify the gender discrepancy...
December 13, 2018: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/30548991/lactation-intensity-and-duration-to-postpartum-diabetes-and-prediabetes-in-women-with-gestational-diabetes
#13
Yun Shen, Junhong Leng, Weiqin Li, Shuang Zhang, Huikun Liu, Ping Shao, Peng Wang, Leishen Wang, Huiguang Tian, Cuilin Zhang, Xilin Yang, Zhijie Yu, Lifang Hou, Jaakko Tuomilehto, Gang Hu
OBJECTIVE: To investigate the association of lactation intensity and duration with postpartum diabetes and prediabetes risks among Chinese women with a history of GDM. METHODS: We included 1260 women with a history of GDM who participated in the whole populationꞋs GDM universal screening survey by using World Health OrganizationꞋs criteria. Lactation intensity and lactation duration were collected by a standardized questionnaire. Postpartum diabetes and prediabetes were confirmed by an oral glucose tolerance test...
December 13, 2018: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/30548982/adipokines-and-macrophage-markers-during-pregnancy-possible-role-for-scd163-in-prediction-and-progression-of-gestational-diabetes-mellitus
#14
Thor Ueland, Annika E Michelsen, Pål Aukrust, Tore Henriksen, Jens Bollerslev, Tove Lekva
AIMS: The risk of gestational diabetes mellitus (GDM) is increased in overweight and obese women potentially involving secreted mediators from adipose tissue. Our main aim was to evaluate if circulating adipokines and monocyte/macrophage markers were dysregulated in GDM and the influence body mass and indices of glucose metabolism had on this association. We further explored if early detection of these markers improved prediction of GDM and if they remained modified during long-term follow-up...
December 13, 2018: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/30548967/applicability-of-telemedicine-in-the-screening-of-diabetic-retinopathy-dr-the-first-multicentre-study-in-italy-the-no-blind-study
#15
Ferdinando Carlo Sasso, Pia Clara Pafundi, Aldo Gelso, Valeria Bono, Ciro Costagliola, Raffaele Marfella, Celestino Sardu, Luca Rinaldi, Raffaele Galiero, Carlo Acierno, Chiara de Sio, Luigi Elio Adinolfi
AIMS: Diabetic retinopathy (DR) represents the main cause of blindness among adults in the industrialized Countries. Use of telemedicine could offer an easy, smart specialist fundus oculi examination, as well as putting in a screening program many patients who otherwise would be excluded. MATERIALS AND METHODS: The NO Blind is a transversal, multicentre, observational study. Its pilot phase involved nine public outpatient clinics for six months. As endpoint of the study, we assessed the prevalence of DR by retinography in a subset of the Italian population...
December 13, 2018: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/30521699/intensive-versus-standard-multifactorial-cardiovascular-risk-factor-control-in-screen-detected-type-2-diabetes-5-year-and-longer-term-modelled-outcomes-of-the-addition-leicester-study
#16
David Webb, Jolyon Dales, Francesco Zaccardi, Sian Hill, Corran Moore, Azhar Farooqi, Simon Griffin, Melanie Davies, Kamlesh Khunti
AIMS: Diabetes treatment algorithms recommend intensive intervention in those with a shorter duration of disease. Screening provides opportunities for earlier multifactorial cardiovascular risk factor control. Using data from the ADDITION-Leicester study (NCT00318032), we estimated the effects of this approach on modelled risk of diabetes-related complications in screen-detected patients. METHODS: A total of 345 (41% South Asian) people with screen-detected type 2 diabetes were cluster randomised to receive 5 years of (1) intensive multifactorial risk factor intervention or (2) standard treatment according to national guidance...
December 6, 2018: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/30520255/effect-of-simulation-education-and-case-management-on-glycemic-control-in-type-2-diabetes-patients
#17
Hong Ji, Ronghao Chen, Yong Huang, Wenqin Li, Chunhui Shi, Juan Zhou
BACKGROUND: The aim of the study was to investigate whether simulation education (SE) and case management had any effect on glycemic control in type 2 diabetes (T2DM) patients. METHODS: In this single center pilot trial, 100 T2DM patients who received medication and basic diabetes self-management education (DSME) were randomly divided into a control group (n=50) and an experimental group (n=50), who received SE and a case management program. Evaluation of biochemical indices was conducted at baseline and after 6 months...
December 5, 2018: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/30517978/glucose-homeostasis-in-statin-users-the-lifestat-study
#18
Thomas Morville, Tine Dohlmann, Anja B Kuhlman, Tine Monberg, Mimmi Torp, Bolette Hartmann, Jens J Holst, Steen Larsen, Jørn W Helge, Flemming Dela
Background Statins are widely used to lower cholesterol concentrations in both primary and secondary prevention of cardiovascular disease. The treatment increases the risk of muscle pain (myalgia) and of type 2 diabetes. However, the underlying mechanisms remain disputed. Methods We investigated whether statin induced myalgia is coupled to impaired glucose homeostasis using oral glucose tolerance test (OGTT), intravenous glucose tolerance test (IVGTT) and the hyperinsulinemic euglycemic clamp. We performed a cross-sectional study of statin users without CVD (primary prevention) stratified into a statin myalgic (M; n=25) and a non-myalgic (NM; n=39) group as well as a control group (C; n=20) consisting of non-statin users...
December 5, 2018: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/30515958/pharmacogenetics-of-type-2-diabetes-mellitus-the-route-toward-tailored-medicine
#19
REVIEW
Gaia Chiara Mannino, Francesco Andreozzi, Giorgio Sesti
Type 2 diabetes mellitus (T2DM) is a chronic disease that has reached the levels of a global epidemic. In order to achieve optimal glucose control it is often necessary to rely on combination therapy of multiple drugs or insulin, because uncontrolled glucose levels result in T2DM progression and enhanced risk of complications and mortality. Several anti-hyperglycemic agents have been developed over time, and T2DM pharmacotherapy should be prescribed based on suitability for the individual patient's characteristics...
December 4, 2018: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/30513132/motivation-interviewing-to-improve-adhesion-behaviour-for-the-prevention-of-diabetic-foot-ulceration
#20
REVIEW
Jodi Binning, Jim Woodburn, Sicco A Bus, Ruth Barn
Diabetic foot ulceration is a major complication associated with high morbidity. Little evidence exists on which interventions are effective at preventing ulceration. Participants who are adherent to self-care behaviours have significantly better outcomes. Motivational interviewing is an intervention that has been used successfully for conditions where adherence is important, such as reduction of obesity and HbA1c levels. A systematic review was conducted to determine whether motivational interviewing is effective at improving adherence for the prevention of Diabetic Foot Ulceration...
December 4, 2018: Diabetes/metabolism Research and Reviews
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