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Yun-Peng Sun, Li-Li Zhu, Jin-Song Liu, Yang Yu, Zhong-Yu Zhou, Gang Wang, Guo-Kai Wang
Five new limonoids, swieteliacates A-E (1-5) and a tirucallane-type triterpenoid, swietesenin (6), together with four known compounds (7-10) were isolated from fruit of Swietenia macrophylla. Their structures were determined by spectroscopic analyses. The new compounds were tested in vitro for their cytotoxic effects against five human cancer cell lines. Compound 2 exhibited moderate cytotoxic activities against SW480 and HL-60 cancer cell lines with IC50 values of 30.6 and 32.9μM, respectively.
January 8, 2018: Fitoterapia
Yong Luo, Xiao-Zhen Li, Bin Xiang, Qi Luo, Jia-Wang Liu, Yong-Ming Yan, Qin Sun, Yong-Xian Cheng
Three new diterpenoids, spicatusenes A-C (1-3), and eleven known ones (4-14) were isolated from the aerial parts of Clerodendranthus spicatus. Their structures were identified by spectroscopic methods. The cytotoxic activities of all the compounds against human cancer cells (HL-60, SMMC-7721, A-549, MCF-7, and SW-480) were examined and found that compounds 2, 3, 6, 8, 10, and 13 were active against one or more cancer cell lines. Besides, the renoprotective effects of all the isolates in TGF-β1-induced rat kidney fibroblasts revealed that compounds 3-7, 9, 13, and 14 were beneficial for renal fibrosis...
January 5, 2018: Fitoterapia
Zhi-Li Wu, Jin-Xin Wang, Li-Ping Chen, Hong-Yuan Dong, Hui-Liang Li, Wei-Dong Zhang
Five rare sesquiterpene lactone dimers, vlasouliolides E-I, were isolated from Vladimiria souliei. Their chemical structures were elucidated by spectroscopic analysis. Furthermore, 2 and 4 were unambiguously confirmed by Cu-Kα X-ray crystallographic analysis. Compounds 1, 2, 4 and 5 exhibited significant anti-inflammatory activity against LPS-induced NO production in RAW 264.7 cells with IC50 values of 1.88, 4.89, 7.24 and 2.46μM, respectively. Additionally, compounds 1 and 2 were revealed with potent inhibitory activity of the phosphorylation progress of NF-κB P65...
January 4, 2018: Fitoterapia
Fengyan Bao, Kaiyin Yang, Canrong Wu, Suyu Gao, Penghe Wang, Lixia Chen, Hua Li
Hexokinase 2 (HK2), a rate-limiting enzyme in the first step of glycolysis pathway, expresses at high level in cancer cells compared with normal cells. HK2 provides a new target for cancer therapy due to its pivotal role in tumor tumourigenic and metastatic process. The structure-based virtual ligand screening in a small in-house database of natural products predicted that a new steroid, (22E,24R)-6β-methoxyergosta-7,9(11),22-triene-3β,5α-diol (2) from Ganoderma sinense has high binding affinity to HK2 with significant calculated binding free energy...
January 3, 2018: Fitoterapia
Guang-Jie Zhang, Bin Li, Li Chen, Ying Tian, Shi-Jun Liu, Hui-Min Cui, Jun-Xing Dong
Five new compounds, including four new isocoumarin derivatives [orychophramarin A-D (1-4)] and a new monoterpene glycoside [orychovioside A (5)], together with fourteen known compounds were isolated from the seeds of Orychophragmus violaceus. Their structures were established on the basis of chemical evidence and spectroscopic analysis. Compound 1 showed significant cytotoxicity against HCT-116 and Hela cell lines compared with the positive control group (Cisplatin) with IC50 values of 5.10 and 8.91μM, respectively...
December 28, 2017: Fitoterapia
Xiao-Hong Zheng, Jing Yang, Jun-Jiang Lv, Hong-Tao Zhu, Dong Wang, Min Xu, Chong-Ren Yang, Ying-Jun Zhang
Four new cleistanthane diterpenoids, phyllaciduloids A-D (1-4), were isolated from the roots and stems of Phyllanthus acidus (L.) Skeels (Phyllanthaceae). Their structures were elucidated on the basis of extensive spectroscopic analysis. Phyllaciduloids B-D (2-4) present in their structures with ether bond between C-7 and C-16, which were rarely reported. All the isolates were evaluated for their cytotoxic activities against five human cancer cell lines.
December 27, 2017: Fitoterapia
Dongyan Li, Guang Du, Xuepeng Gong, Jieru Guo, Jinwen Zhang, Chunmei Chen, Yongbo Xue, Hucheng Zhu, Yonghui Zhang
Hyperattenins L (1) and M (2), two new benzoylated polyprenylated phloroglucinol derivatives possessing unusual adamantyl and homoadamantyl core structures, were isolated from the aerial parts of Hypericum attenuatum. Their structures were determined by extensive NMR spectroscopic methods. Compound 1 possesses an unusual tetracyclo[,10.01,5]tridecane skeleton, representing the second report of natural product with this carbon skeleton. Compound 2 features an unexpected 2,3,13-trioxapentacyclo[7.5.3...
December 26, 2017: Fitoterapia
Jorgelina L Pergomet, Melina G Di Liberto, Marcos G Derita, Andrea B J Bracca, Teodoro S Kaufman
The antifungal activity of pterophyllin 2, pterophyllin 4, a 5-desmethyl analog of the latter and some of their synthetic intermediates, against three postharvest phytopathogenic fungi, was evaluated. The target fungi were Rhizopus stolonifer, Botrytis cinerea and Monilinia fructicola, which affect fruits worldwide, causing important economic losses. The tests were carried out with imazalil and carbendazim as positive controls. Minimum inhibitory concentrations and minimum fungicidal concentrations were determined, and the morphology of the colonies was examined microscopically...
December 26, 2017: Fitoterapia
Zhang-Gui Ding, Jian-Hai Ding, Jiang-Yuan Zhao, Wei-Xun Chunyu, Ming-Gang Li, Shao-Jie Gu, Fei Wang, Meng-Liang Wen
A new phenylspirodrimane dimer, named stachartarin A (1), was isolated from cultures of the tin mine tailings-associated fungus Stachybotrys chartarum. Its structures were elucidated by means of spectroscopic methods. At the same time, the compound was tested for its cytotoxicity against HL-60, SMMC-7721, A-549, MCF-7, and SW480 cells.
December 26, 2017: Fitoterapia
Sabrin R M Ibrahim, Hossam M Abdallah, Ali M El-Halawany, Ahmed Esmat, Gamal A Mohamed
The three new metabolites: thiotagetin B (2) [(Z)-1″-([2,2'-bithiophen]-5-yl)-8″-chloro-6″,11″-dimethylundeca-6″,10″-dien-2″-yn-9″-one], tagetannin A (9) [3,4-bis-(galloyl-3,5-dimethyl ether)-(α/β)-d-glucopyranose], and tagetannin B (10) [2,3-bis-(galloyl-3,5-dimethyl ether)-(α/β)-d-glucopyranose], along with ecliptal (5-formyl-α-terthiophene) (1), 5-(4-hydroxybut-1-ynyl)-2,2'-bithiophene (3), scopoletin (4), p-hydroxybenzoic acid (5), protocatechuic acid methyl ester (6), gallic acid (7), and patuletin 7-O-β-d-glucoside (8) were isolated from the aerial parts of Tagetes minuta L...
December 26, 2017: Fitoterapia
Fa-Liang An, Dong-Mei Sun, Xiao-Bing Wang, Lei Yang, Yong-Yin, Jun Luo, Ling-Yi Kong
Phytochemical investigation of the fruits from Trichilia connaroides led to the isolation of four rare 1,2-seco phragmalin-type limonoids (1-4) with C-7/28 δ-lactone ring along with two known triterpenoids (5-6). An oxygen bridge between C-1 and C-2 formed an rare 9-oxa-tricyclo[,10]undecane-2-ene moiety in structure of 1 and 2, and 3-4 possessed a bicyclo[5.2.14,10]decane skeleton. Their structures were established based on extensive spectroscopic methods and their absolute configurations of 1 were confirmed by TDDFT/ECD calculation and comparative analysis...
December 26, 2017: Fitoterapia
Matthew Piggott
No abstract text is available yet for this article.
December 22, 2017: Fitoterapia
Ramsay S T Kamdem, Pascal Wafo, Amadou Dawe, Dieu Ne Dort Nganteng, Umeokoli Blessing Ogechukwu, Saima Rasheed, Omeje E Ogechukwu, Gamall Makhloufi, Zulfiqar Ali, Ikhlas A Khan, Muhammad Iqbal Choudhary, Christoph Janiak, Peter Proksch
A new γ-lactone triterpenoid, Evodoulolide (1) and a new triterpenoid Duboscic acid B (2), along with five known compounds, maslinic acid (3), arboreic acid (4), (E)-3-(4-hydroxyphenyl)-N-[2-(4-hydroxyphenyl) ethyl] prop-2-enamide (5), (E)-heptacos-19-enoic acid (6) and 11β,12β-epoxyfriedours-14-en-3α-ol (7) were isolated from the trunk wood of Duboscia macrocarpa. Their structures were elucidated from extensive 1D- and 2D-NMR and MS and by comparison of their spectra with published data. Compounds 1, 3, 5 and 6 exhibited significant α-glucosidase inhibitory activity...
December 19, 2017: Fitoterapia
Meryem Lehbili, Abdulmagid Alabdul Magid, Jane Hubert, Ahmed Kabouche, Laurence Voutquenne-Nazabadioko, Jean-Hugues Renault, Jean-Marc Nuzillard, Hamid Morjani, Amin Abedini, Sophie C Gangloff, Zahia Kabouche
This study presents the chemical profile investigation of a 70% ethanol extract obtained from Scabiosa stellata, a medicinal herbaceous traditionally used to treat heel cracks. A 13C NMR-based dereplication methodology was firstly applied on centrifugal partition chromatography-generated fractions in order to quickly identify the major compounds of the extract. The dereplication process was then completed by semi-preparative high-performance liquid chromatography in order to identify unknown or minor compounds...
December 19, 2017: Fitoterapia
Guo-Long Li, Hong-Jiang Xu, Shao-Hua Xu, Wei-Wei Wang, Bo-Yang Yu, Jian Zhang
To discover new potent cytotoxic steroidal saponins, a series of tigogenin neoglycosides were synthesized via oxyamine neoglycosylation for the first time. The preliminary bioassays for their in vitro antitumor activities against five human cancer cell lines (A375, A-549, HCT-116, HepG2 and MCF-7) were conducted. The results revealed a sugar-dependent activity profile of their cytotoxicity, the glycoconjugation converted the non-active tigogenin to the most potential product Tg29 ((3R)-N-methoxyamino-tigogenin-β-2-deoxy-d-galactoside) with IC50 value of 2...
December 18, 2017: Fitoterapia
Anderson K Ueno, Aline F Barcellos, Thais A Costa-Silva, Juliana T Mesquita, Daiane D Ferreira, Andre G Tempone, Paulete Romoff, Guilherme M Antar, João Henrique G Lago
Baccharis retusa, a medicinal Brazilian plant from Asteraceae, has been used in Brazilian folk medicine to treatment of several illnesses, including parasitic diseases. Bioactivity-guided fractionation of the n-hexane extract from the aerial parts of B. retusa resulted in the isolation and characterization of three active related diterpenes: ent-15β-senecioyl-oxy-kaur-16-en-19-oic acid (1), ent-kaur-16-en-19-oic (2) and ent-16-oxo-17-nor-kauran-19-oic (3) acids. The structures of isolated compounds were defined by spectroscopic analysis, including NMR and HRESIMS...
December 18, 2017: Fitoterapia
Jun-Feng Wang, Li-Man Zhou, Sheng-Tian Chen, Bin Yang, Sheng-Rong Liao, Fan-Dong Kong, Xiu-Ping Lin, Fa-Zuo Wang, Xue-Feng Zhou, Yong-Hong Liu
Seven new compounds, including four new chlorinated diphenyl ethers, namely chrysines A-D (1-4), one new dichlorinated xanthone, chrysoxanthone (5), dichloroorcinol (6), and one new benzeneacetic acid derivative, 3-isopentyl-4-hydroxy phenylacetic acid methyl ester (7), along with fourteen known compounds (8-21), were isolated from a deep-sea-derived fungus Penicillium chrysogenum SCSIO 41001. Their structures were determined by extensive spectroscopic methods and X-ray single-crystal diffraction analysis. All of the isolated compounds (1-21) were evaluated for their α-glucosidase inhibitory activity using PNPG method...
December 18, 2017: Fitoterapia
Chen-Yang Jia, Li-Yong Xu, Xiang Yu, Yu-Bing Ding, Bing Jin, Ming-Zhi Zhang, Wei-Hua Zhang, Guang-Fu Yang
Streptochlorin, a small indole alkaloid isolated from marine Streptomyces sp., exhibits a wide range of potent biological activities. An efficient and economic synthetic protocol for streptochlorin has been developed and validated, 4 steps from indole in a total yield of 45%, and further applied for the synthesis of its analogues. Biological testing showed that most of the target compounds exhibited potential antifungal activity in the primary assays, especially compounds 6, 7 and 9c were the most active ones, representing effective activity against the phytopathogenic fungi screened in preliminary test and might be explored for the study of mode of action in the future...
December 18, 2017: Fitoterapia
Yan-Rong Zeng, Li-Ping Wang, Zhan-Xing Hu, Ping Yi, Wan-Xia Yang, Wei Gu, Lie-Jun Huang, Chun-Mao Yuan, Xiao-Jiang Hao
Six new compounds, including three pyrone derivatives (2-4), one new flavone (5), and two new naturally-occurring compounds (1 and 6), together with 16 known compounds were isolated from the leaves and twigs of Hypericum monogynum. In addition, compounds 2-4 are racemates. Their structures and absolute configurations were determined on the basis of extensive analysis of spectroscopic data and ECD calculation. All compounds were evaluated for the inhibitory effects on α-glucosidase, compounds 1, 5, and 7 showed moderate inhibitory activities with IC50 values of 161...
December 18, 2017: Fitoterapia
Jun Li, Wen-Qiong Wang, Wei-Bin Song, Li-Jiang Xuan
Chemical investigation of Euphorbia helioscopia resulted in the identification of seven new triterpenes named euphorbatrine A-G (1-7), including two (19αH)-lupane (1-2) and three (9βH)-lanostane (4-6), which are very rare metabolites from plants. Their structures were elucidated by extensive spectroscopic analysis, X-ray crystallography and chemical methods. Compounds 5 and 6 triggered apoptosis of Hela-/- cell with EC50 values of 1.59±0.25 and 26.48±0.78μM, respectively.
December 18, 2017: Fitoterapia
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