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Pan Wang, Jin-Hai Yu, Kongkai Zhu, Yinyin Wang, Zhi-Qiang Cheng, Cheng-Shi Jiang, Jun-Gui Dai, Jun Wu, Hua Zhang
Seven new phenolic bisabolane sesquiterpenoids, (7R,10S)-7,10-epoxysydonic acid (1), (7S,10S)-7,10-epoxysydonic acid (2), (7R,11S)-7,12-epoxysydonic acid (3), (7S,11S)-7,12-epoxysydonic acid (4), 7-deoxy-7,14-didehydro-12-hydroxysydonic acid (5), (Z)-7-deoxy-7,8-didehydro-12-hydroxysydonic acid (6), and (E)-7-deoxy-7,8-didehydro-12-hydroxysydonic acid (7), along with five known analogues (8-12), were obtained from the culture of an endophytic fungus Aspergillus sp. xy02 isolated from the leaves of a Thai mangrove Xylocarpus moluccensis...
March 12, 2018: Fitoterapia
Nwet Nwet Win, So-Yeun Woo, Hla Ngwe, Prema, Chin Piow Wong, Takuya Ito, Yasuko Okamoto, Masami Tanaka, Hiroshi Imagawa, Yoshinori Asakawa, Ikuro Abe, Hiroyuki Morita
Two new tetrahydrofuran lignans, taungtangyiols A (1) and B (2), and eight known furofuran lignans (3-10), were isolated from the chloroform extract of Premna integrifolia wood collected in Myanmar. Their structures were elucidated by extensive spectroscopic techniques. The X-ray crystal structure of 1 clearly indicated its relative configuration. Taungtangyiols A (1) and B (2) inhibited the deposition of melanin in B16F10 mouse melanoma cells, with IC50 values of 50.7 and 40.9 μM, respectively, without notable cytotoxicity...
March 11, 2018: Fitoterapia
Yuan-Lin Cao, Meng-Han Zhang, Yun-Fang Lu, Chen-Yang Li, Jin-Shan Tang, Miao-Miao Jiang
Six new cardenolides (1-6), including three 14-hydroxylated cardenolides and three 14-carbonylated cardenolides were isolated from the dried aerial parts of Nerium oleander Linn in addition to twenty-seven known compounds (7-33). Their structures were elucidated on the basis of extensive spectroscopic evidences and single-crystal X-ray diffraction analysis. Compounds 1, 4, 7-10 and 13 exhibited significant cytotoxicity against four colon cancer cell lines (HCT116, HT29, SW620, RKO), one gastric cancer cell line (GT) and one cervical cancer cell line (HeLa) in vitro...
March 11, 2018: Fitoterapia
Verónica Egas, Gabriela Salazar-Cervantes, Irma Romero, Carlos A Méndez-Cuesta, José Luis Rodríguez-Chávez, Guillermo Delgado
No abstract text is available yet for this article.
March 11, 2018: Fitoterapia
Fan Yang, Yan-Yun Li, Jie Tang, Fan Sun, Hou-Wen Lin
A series of 4-methylidene sterols including three new compounds 1-3, were isolated from the marine sponge Theonella swinhoei. The structures of new compounds were determined on the basis of spectroscopic analyses. Compounds 3, 5, and 6 showed cytotoxicities against U937, MCF-7, and PC-9 cancer cells with IC50 in the range of 1.6-8.8 μM. The new compound 3 exhibited remarkable proapoptotic activity in breast cancer cells. Mechanically, 3 significantly triggered reactive oxygen species (ROS) accumulation resulting in apoptosis and DNA damage in breast cancer cells...
March 11, 2018: Fitoterapia
Xingrong Peng, Xia Wang, Long Chen, Han Yang, Lei Li, Shuangyang Lu, Lin Zhou, Minghua Qiu
Ganoderma cochlear, as edible and medicinal fungus, has long been used to prevent and treat various diseases. As our continuously phytochemical investigation of this fungus, a HPLC-UV-guided method led to the isolation of nine previously undescribed aromatic meroterpenoids with different ring systems, including six pairs of racemates, (±)-cochlearins A-E, G (1-5, 7), and three new analogues, cochlearins F, H and I (6, 8, 9). Their structures were elucidated by extensive 1D, 2D NMR spectroscopic data and MS analyses...
March 11, 2018: Fitoterapia
Rui Guo, Bin Lin, Xin-Yue Shang, Le Zhou, Guo-Dong Yao, Xiao-Xiao Huang, Shao-Jiang Song
Eight new phenylpropanoids (1a/1b, 2-4, 5a/5b and 6) including two pairs of enantiomers (1a/1b and 5a/5b), along with a known analogue (7) were isolated from the fruit of Crataegus pinnatifida. Their structures were elucidated using comprehensive spectroscopic methods. Compounds 1a/1b and 5a/5b were separated successfully by chiral chromatographic column. The absolute configurations of enantiomers were determined by comparison between the experimental and calculated electronic circular dichroism (ECD) spectra...
March 10, 2018: Fitoterapia
Imane Benabdelaziz, Santiago Gómez-Ruiz, Mohammed Benkhaled, Sandra Carralero, Patricia Schenker, Andrea Salm, Jürg Gertsch, Hamada Haba
From acetonic extract of the whole plant Euphorbia pterococca Brot. (Euphorbiaceae), four new cycloartane-type ester triterpenes named cycloartenyl-2'E,4'E-decadienoate (1), cycloartenyl-2'E,4'Z-decadienoate (2), 24-methylenecycloartanyl-2'E,4'Z-tetradecadienoate (3), and 24-oxo-29-norcycloartanyl-2'E,4'Z-hexadecadienoate (4) were obtained along with nine known tetracyclic triterpenes (5-13). Their structures were established mainly by extensive use of spectroscopic techniques, including 1D (1 H and13 C) and 2D homo- and heteronuclear NMR experiments (COSY, HSQC, HMBC and NOESY), and mass spectrometry (HRESIMS), and by comparison with data reported in the literature...
March 7, 2018: Fitoterapia
Miku Maruyama, Miki Kobayashi, Takeshi Uchida, Eisaku Shimizu, Hironori Higashio, Misa Ohno, Shota Uesugi, Ken-Ichi Kimura
Amber is fossilized tree resin and several biologically active compounds were isolated from ambers using the growth-restoring activity of the mutant yeast [Saccharomyces cerevisiae (zds1∆ erg3∆ pdr1∆ pdr3∆)] involving Ca2+ -signal transduction. The aim of this study is to investigate the anti-allergic effect of both the methanol extract of Kuji amber (MEKA) and its main biologically active constituent, kujigamberol (15,20-dinor-5,7,9-labdatrien-18-ol) having activity against the mutant yeast. Both MEKA and kujigamberol inhibited the degranulation of RBL-2H3 cells by stimulation of thapsigargin (Tg) (IC50  = 15...
March 5, 2018: Fitoterapia
Xu Yang, Wenjie Zhang, Xixiang Ying, Didier Stien
Three new compounds, identified as (3S)-5-hydroxy-3-(2-hydroxybenzyl)-7-methoxychroman-4-one, oleracone C (1), 5-hydroxy-3-(2-hydroxybenzyl)-7-methoxy-4H-chromen-4-one, oleracone D (2), and 1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(2-hydroxyphenyl)propan-1-one, oleracone E (4), together with one new natural product, 5,7-dimethoxy-4-O-2'-cycloflavan (3) already known from synthesis, and two known compounds, (2S)-5,2'-dihydroxy-7-methoxyflavanone (5) and 2',4'-dihydroxy-4,6'-dimethoxychalcone (6) were isolated from the Portulaca oleracea L...
March 1, 2018: Fitoterapia
Federica Pollastro, Maria Talmon, Simone Gaeta, Silvia Rossi, Annalisa Lopatriello, Luigia Grazia Fresu
The discovery of taste receptors hTAS2Rs expression in extra oral tissue, especially in the gastrointestinal tract and in the respiratory system, has endowed bitter receptors of functionalities that exceed the simple perception of taste and flavour. In particular, stimulation of hTAS2Rs by bitter agents in the airway smooth muscle triggers bronchodilation of possible pharmacological relevance. To study the receptor localization in pulmonary smooth muscle cells and to investigate their biological response to hTAS2R38 activation, we have developed a fluorescent probe for hTAS2R38 starting from the sesquiterpene lactone costunolide, available in multigram amounts from Artemisia umbelliformis Lam...
February 27, 2018: Fitoterapia
Xiuyong Huang, Zeping Chen, Shiwen Zhou, Pengyun Huang, Zhenjian Zhuo, Sudan Zeng, Lei Wang, Yong Wang, Chuanshan Xu, Haiyan Tian
Six new cassaine diterpenoids (1, 3-7), along with three known ones (2, 8-9) were isolated from the seeds of Erythrophleum fordii. Their structures were elucidated by extensive spectroscopic methods and acid hydrolysis. Compound 2 was tested to be the most potent one and showed more sensitive activities on MCF-7 and A549 cancer cells with IC50 values of 3.66 ± 1.20 and 2.87 ± 0.46 μM, respectively. Furthermore, compound 2 reduced the number of cell colonies significantly in a dose-dependent manner in the colony formation assay and triggered apoptosis of MCF-7 cell...
February 26, 2018: Fitoterapia
S Sarshar, J Sendker, X Qin, F M Goycoolea, M R Asadi Karam, M Habibi, S Bouzari, U Dobrindt, A Hensel
Fruits from Apium graveolens (Celery) are used traditionally in Persian and European medicine for the treatment of uncomplicated urinary tract infections. No data are available on A. graveolens extract on the interplay between uropathogenic E. coli and the eukaryotic host cells and on quorum sensing of the bacteria. The present study aimed to characterize an antiadhesive and anti quorum sensing effect of a characterized A. graveolens extract by specific in vitro assays and to correlate these effects with in vivo data obtained by an animal infection model...
February 26, 2018: Fitoterapia
François Chassagne, Mohamed Haddad, Aurélien Amiel, Chiobouaphong Pharkeovilay, Chanthanom Manithip, Geneviève Bourdy, Eric Deharo, Guillaume Marti
Liver cancer is a major health burden in Southeast Asia, and most patients turn towards the use of medicinal plants to alleviate their symptoms. The aim of this work was to apply to Southeast Asian plants traditionally used to treat liver disorders, a successive ranking strategy based on a comprehensive review of the literature and metabolomic data in order to relate ethnopharmacological relevance to chemical entities of interest. We analyzed 45 publications resulting in a list of 378 plant species, and our point system based on the frequency of citation in the literature allowed the selection of 10 top ranked species for further collection and extraction...
February 22, 2018: Fitoterapia
Raimundo Gonçalves de Oliveira Júnior, Christiane Adrielly Alves Ferraz, Jackson Roberto Guedes da Silva Almeida, Raphaël Grougnet, Valérie Thiéry, Laurent Picot
PURPOSE: Tumor cells are spontaneously or adaptively resistant to chemotherapeutic drugs, eventually leading to the selection of multiresistant cells responsible for tumor growth and metastasis. Chemosensitization of tumor cells to conventional drugs using non-toxic natural products is a recent and innovative strategy aiming to increase the cytotoxic efficiency of anticancer drugs, limit their toxic side effects and delay the appearance of acquired chemoresistance. This systematic review summarizes data obtained from preclinical studies reporting the use of natural products to sensitize tumor cells to chemotherapeutic agents...
February 21, 2018: Fitoterapia
Yang Liu, Yu Zhang, Shao-Nong Chen, J Brent Friesen, Dejan Nikolić, Mary P Choules, James B McAlpine, David C Lankin, Richard A Gemeinhart, Guido F Pauli
Natural Deep Eutectic Solvent (NADES) species can exhibit unexpected solubilizing power for lipophilic molecules despite their simple composition, hydrophilic organic molecules and water. In the present study, the unique properties of NADES species were applied in combination with a model polymer system: a hydrophilic chitosan/alginate hydrogel. Briefly, NADES species (e.g., mannose-dimethylurea-water, 2:5:5, mole/mole) formed matrices to 1) dissolve lipophilic molecules (e.g., curcumin), 2) load lipophilic molecule(s) into the hydrogel, and 3) spontaneously vacate from the system...
February 20, 2018: Fitoterapia
Cui-Cui Jia, Jing-Jing Xue, Chi Gong, Xin-Yu Li, Da-Hong Li, Zhan-Lin Li, Hui-Ming Hua
Bioassay-guided fractionation of the dichloromethane-soluble portion of the stems of Garcinia paucinervis led to the isolation of eight new xanthones, including three pairs of enantiomers, (+) and (-) paucinervins L-N (1a-3a, and 1b-3b), one optically pure compound, (-) paucinervin O (4), and one new analogue, paucinervin P (5), as well as thirteen known xanthones (6-18). Their structures were established by detailed analysis of extensive spectroscopic data. The absolute configurations of 1-4 were confirmed by ECD calculations...
February 20, 2018: Fitoterapia
Yuqin Gu, Peiyu Ding, Zhipeng Liang, Yan Song, Yonghong Liu, Guangtong Chen, Jian Lin Li
As an attempt to utilize of rare earth elements as a novel method to activate the silent genes in fungus, the marine-derived fungus Penicillium citrinum was cultured under ordinary laboratory fermentation conditions in the presence of scandium chloride (ScCl3 , 50 μM), and chemical investigation led to the isolation and characterization of three new peptide derivatives (1-3), along with four known pyrrolidine alkaloids (4-7). Those structures were elucidated by spectroscopic data interpretation, as well as chemical reactions...
February 20, 2018: Fitoterapia
Tamam El-Elimat, José Rivera-Chávez, Joanna E Burdette, Austin Czarnecki, Maram B Alhawarri, Mohammad Al-Gharaibeh, Feras Alali, Nicholas H Oberlies
Four new homoisoflavonoids, 7-O-methyl-8-demethoxy-3'-hydroxy-3,9-dihydropunctatin (4), 6-hydroxy-8-demethoxy-4'-O-methyl-3,9-dihydropunctatin (8), 7,4'-O-dimethyl-8-demethoxy-3,3'-dihydroxy-3,9-dihydropunctatin (13), and 7-O-methyl-3-hyroxy-3,9-dihydropunctatin (14) were identified from a chloroform extract of the bulbs of Bellevalia flexuosa, along with 13 known analogues. The structures were determined by analysis of HRMS and NMR data, while ECD spectroscopy enabled the assignment of the absolute configurations of the new compounds 4, 8, 13 and 16...
February 19, 2018: Fitoterapia
Wen-Ping Ding, Kun Hu, Miao Liu, Xing-Ren Li, Rong Chen, Xiao-Nian Li, Xue Du, Pema-Tenzin Puno, Han-Dong Sun
Five new schinortriterpenoids, propinqtrilactones A and B (1 and 2) with rare lancischiartane scaffold, and propindilactones V-X (3-5), were isolated from the stems and leaves of Schisandra propinqua var. propinqua. Their structures were elucidated on the basis of comprehensive spectroscopic and mass spectrometric analysis. The absolute configurations of 1-5 were determined by CD methods, X-ray diffraction analysis and theoretical calculations. 4 was tested for its cytotoxic activities against five human tumor cell lines...
February 14, 2018: Fitoterapia
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