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Ying Huang, Shuai-Bing Zhang, He-Ping Chen, Zhen-Zhu Zhao, Zheng-Hui Li, Tao Feng, Ji-Kai Liu
Five new acetylenic acid analogues, craterellynes A-E (1-5), together with three known compounds (6-8), were isolated from the fruiting bodies of Craterellus lutescens. Their structures were elucidated on the basis of spectroscopic and chemical means. The absolute configurations of 1-6 were determined by the modified Mosher method.
October 20, 2016: Fitoterapia
Yu-Chen Liu, Jia Su, Xing-De Wu, Zhi-Jun Zhang, Min Fan, Qin-Feng Zhu, Juan He, Xiao-Nian Li, Li-Yan Peng, Xiao Cheng, Qin-Shi Zhao
A series of new Lycopodium alkaloids, namely 1-epi-malycorin A (1), 1-epi-17S-hydroxymalycorin A (2), 6α-hydroxyphlegmariurine A (3), 2S,4R-dihydroxyfawcettimine (4), and 16-hydroxylycodine (5), together with 24 known ones, have been isolated from the club moss Phlegmariurus henryi. The structures of the new compounds were determined by extensive spectroscopic analysis, including 1D and 2D NMR, as well as X-ray crystallographic analysis. Among them, the absolute configurations of 1, 2, and 4 and the structure of 3 were confirmed on the basis of the single-crystal X-ray crystallographic analysis...
October 18, 2016: Fitoterapia
Dao-Ran Pang, Xiao-Qin Su, Zhi-Xiang Zhu, Jing Sun, Yue-Ting Li, Yue-Lin Song, Yun-Fang Zhao, Peng-Fei Tu, Jiao Zheng, Jun Li
Eight new flavonoid dimers, named cochinchinenins I-M (1-5), including three pairs of enantiomers (1a/1b-3a/3b) and two optically pure flavonoid dimers (4-5), along with a known analogue (6), were isolated from total phenolic extract of the red resin of Dracaena cochinchinensis (Chinese dragon's blood). The planar structures of 1-5 were elucidated by extensive spectroscopic analysis including HRESIMS and 1D/2D NMR. Their absolute configurations were determined on the basis of experimental and calculated electronic circular dichroism (ECD) data...
October 18, 2016: Fitoterapia
Wan Gao, Jia-Wen Hu, Fang Xu, Can-Jing Wei, Meng-Jiao Shi, Jun Zhao, Jia-Jia Wang, Bo Zhen, Teng-Fei Ji, Jian-Guo Xing, Zheng-Yi Gu, Fang Xu
Four new polyisoprenylated benzoylphloroglucinol derivatives, hyperscabrones J-M (1-4), were isolated from the air-dried aerial parts of Hypericum scabrum. Their structures were elucidated by spectroscopic methods and were subsequently confirmed by comparing with data of known compounds. The absolute configuration of the bicyclo[3.3.1]nonane-2,4,9-trione core was defined by the experimental and calculated electronic circular dichroism (ECD) spectra. The evaluation of their hepatoprotective activities against paracetamol-induced HepG2 cell damage showed that compounds 2 and 4 exhibited significant hepatoprotection at 10μM...
October 14, 2016: Fitoterapia
Xue-Ming Zhou, Cai-Juan Zheng, Jia-Ting Wu, Guang-Ying Chen, Jun Chen, Chong-Ge Sun
Five new lactone derivatives decumbic acids A and B (1 and 2), (-)-decumbic acid (3a), (-)- and (+)-dendrolactone (4a and 4b) together with four known compounds (3b and 5-7) were isolated from the stems of Dendrobium nobile. Their structures were elucidated using comprehensive spectroscopic methods. Compounds 3a and 3b, 4a and 4b were isolated as two pair of enantiomers by chiral HPLC. The absolute configurations of 1, 2, 3a, 4a and 4b were determined by optical rotation and X-ray crystallographic analysis...
October 6, 2016: Fitoterapia
Yue Wang, Yulong Han, Fangni Chai, Hongmei Xiang, Tao Huang, Shuming Kou, Bing Han, Xiaobao Gong, Xiaoli Ye
The aim of this study was to investigate the antihypercholesterolemic activity and potential molecular mechanism of columbamine (COL) that was prepared by extraction from Rhizoma Coptidis in hamsters and HepG2 cells. The results displayed that the COL from Rhizoma Coptidis was a safe natural compound with a LD50 0f 1524.6mg/kg and no detectable toxic symptoms during the observation of chronic toxicity. COL dose-dependently reversed the abnormal lipid levels induced by HFHC diet. Specifically, COL(M) and COL(H) significantly reduced the blood lipid levels(TC, TG and LDL-c) and enhanced the fecal contents of TBA by 21...
October 3, 2016: Fitoterapia
Xian-Ping Tang, Shi-Qi Cao, Yan Song, Lan-Shu Zhou
A chemical investigation of the ethanol extract of the aerial parts of Melodinus fusiformis led to the isolation of six new melodinus-type alkaloids, melofusines A-E (1-6), along with one known compound, melodinine B. Structural elucidation of all the compounds was performed by spectral methods such as 1D and 2D NMR, IR, UV and HRESIMS. The isolated compounds were tested in vitro for cytotoxic potential against six tumor cell lines (Hep-2, SCL-1, CAL-27, UMSCC-1, Detroit-562 and TCA-83). As a result, compound 1 exhibited significant cytotoxic activities against all tested tumor cell lines with IC50 values <5μM...
October 3, 2016: Fitoterapia
Huan Yan, Ming-Yu Ba, Xu-Hong Li, Jia-Mei Guo, Xu-Jie Qin, Li He, Zhong-Quan Zhang, Ying Guo, Hai-Yang Liu
Phytochemical investigation on the whole plant of Chloranthus japonicus (Chloranthaceae) led to the isolation and identification of three new lindenane-type sesquiterpenoid dimers, chlorajaponilides F-H (1-3), along with seven known ones (4-10). Their chemical structures were established by extensive spectral evidence. Compounds 1 and 2 are both dimeric sesquiterpenoids featuring a rare hydroperoxy group at C-5. All compounds were tested for their activities on wild type HIV-1 replication and compounds 1, 2, 5, and 9 were effective with EC50 values from 3...
October 2, 2016: Fitoterapia
Mirosław Zagaja, Marta Andres-Mach, Paweł Patrzylas, Daniel Pyrka, Monika Szpringer, Magdalena Florek-Łuszczki, Dorota Żółkowska, Krystyna Skalicka-Woźniak, Jarogniew J Łuszczki
The aim of this study was to determine the effects of xanthotoxin (8-methoxypsoralen) on the protective action of 5 various second- and third-generation antiepileptic drugs (i.e., lacosamide, lamotrigine, oxcarbazepine, pregabalin and topiramate) in the mouse maximal electroshock-induced seizure model. Seizure activity was evoked in adult male albino Swiss mice by a current (25mA, 500V, 0.2s stimulus duration) delivered via auricular electrodes. Drug-related adverse effects were determined in the chimney, grip-strength and passive avoidance tests...
October 1, 2016: Fitoterapia
Barbara Tóth, Erika Liktor-Busa, Edit Urbán, Attila Csorba, Gusztáv Jakab, Judit Hohmann, Andrea Vasas
The main objective of this project was to investigate the antibacterial activity of 19 species (Juncus acutus, J. alpinoarticulatus, J. articulatus, J. compressus, J. conglomeratus, J. effusus, J. filiformis, J. gerardii, J. inflexus, J. maritimus, J. monanthos, J. squarrosus, J. tenuis, J. trifidus, Luzula campestris, L. forsteri, L. luzuloides, L. sudetica and L. sylvatica) belonging to the family Juncaceae against methicillin-resistant S. aureus (MRSA), extended-spectrum β-lactamase (ESBL)-producing C. freundii, E...
October 1, 2016: Fitoterapia
Ya-Jing Liu, Shi-Yang Li, Jie Hou, Yan-Fang Liu, Dan-Dan Wang, Yong-Shan Jiang, Guang-Bo Ge, Xin-Miao Liang, Ling Yang
White Mulberry Root-bark (WMR) is an edible Chinese herbal used for the treatment of inflammation, nephritis and asthma. This study aimed to investigate the inhibitory effects of ethanol extract from WMR against human carboxylesterase 2 (hCE2), as well as to identity and character natural hCE2 inhibitors in this herbal. Our results demonstrated that the ethanol extract of WMR displayed potent inhibitory effects against hCE2, while three major bioactive constitutes in WMR were identified on the basis of LC fingerprinting combined with activity-based screening of LC fractions...
October 1, 2016: Fitoterapia
Byeol Ryu, Hye Mi Kim, Jeong-Hwa Woo, Jung-Hye Choi, Dae Sik Jang
A new acetophenone, 2,4,6-trihydroxy-3-methylacetophenone-2-O-β-d-glucoside (1), together with 21 known compounds; one acetophenone (2), four chromone glycosides (3-6), six phenylpropanoids (7-12), six sesquiterpenoids (13-18), two triterpenoids (19 and 20), one sterol (21), and one tannin (22) were isolated from the flower buds of Syzygium aromaticum (cloves). The structure of the new compound 1 was determined by spectroscopic analyses including 1D-, 2D-NMR and HRMS interpretation. Among the isolates, one acetophenone (2), three phenylpropanoids (10-12), and one sesquiterpenoid (13) were isolated from the flower buds of S...
October 1, 2016: Fitoterapia
Samah M El Sohafy, Aly M Metwally, Abdalla A Omar, Masouda E Amer, Mohamed M Radwan, Maged S Abdel-Kader, Sayed A El Toumy, Mahmoud A ElSohly
The ethanol extract of Cynara cornigera L. was fractionated and the fractions were subjected to hepatoprotective assays using Wistar albino rats at a dose of 500 and 250mg/kg. The liver injury was induced in rats using carbon tetrachloride. Biochemical parameters such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and total bilirubin were estimated as reflections of the liver condition, with silymarin as a positive control. Phytochemical investigation and chromatographic separation of the hepatoprotective fractions led to the isolation of a new sesqui-lignan namely cornigerin (1), along with eight known compounds: apigenin (2), luteolin (3), β-sitosterol glycoside (4), apigenin 7-O-β-D-glucopyranoside (5), luteolin-7-O-β-D-glucopyranoside (6), apigenin-7-O-rutinoside (7), cynarin 1,5-di-O-caffeoylquinic acid (8), and apigenin-7-O-β-D-glucuronide (9)...
September 28, 2016: Fitoterapia
Rulan Qin, Ying Zhao, Yudan Zhao, Wanrong Zhou, Chongning Lv, Jincai Lu
Three new phenolic compounds (1-3), along with five known compounds (4-8) were isolated from the rhizome of Cimicifuga dahurica (Turcz.) Maxim. Their structures were elucidated by spectroscopic methods including 1D-NMR, 2D-NMR and HR-MS techniques. DPPH method and protective effect on PC12 cells against H2O2-induced oxidative damage model were carried to evaluate the antioxidant capability of these compounds. Compound 5 showed significant antioxidant activity with IC50 values 9.33μM in DPPH assay and compound 2 displayed marked neuro-protective effect with 87...
September 28, 2016: Fitoterapia
Ting Yan, Xiangyong Yu, Xianduo Sun, Dali Meng, Jing-Ming Jia
A new steroidal saponin, furotrilliumoside (FT) was isolated from the roots and rhizomes of Trillium tschonoskii Maxim. Its structure was elucidated on the basis of 1D- and 2D-NMR spectroscopic data as well as HR-ESI-MS analysis. FT showed superior activity of inhibiting NO production of RAW264.7 cells induced by lipopolysaccharide (LPS) in the preliminary biological screening. In order to develop novel therapeutic drug for acute and chronic inflammatory disorders, the anti-inflammatory activity and underlying mechanism of FT were investigated in LPS-induced RAW264...
September 28, 2016: Fitoterapia
Meng Song, Li Li, Meng Li, Yonghong Cha, Xuming Deng, Jianfeng Wang
Streptococcus pneumoniae is an important human pathogenic bacterium that can cause various life-threatening infections. Pneumolysin (PLY), the pore-forming toxin that forms large pores in the cell membrane, is a key virulence factor secreted by S. pneumoniae that penetrates the physical defenses of the host and plays an important role in the pathogenesis of pneumococcal diseases, such as pneumonia, meningitis, bacteremia and otitis media. This study showed that apigenin, one of the bioflavonoids widely found in herbs, inhibits PLY-induced hemolysis by inhibiting the oligomerization of PLY and has no anti-S...
September 28, 2016: Fitoterapia
Ju-Yan Zheng, Qian Wang, Zhao-Xia L Iu, Cheng-Xiong Liu, Zhi-Yong Guo, Hong-Qi Zhang, Hai-Bo He, Xuan Tu, Kun Zou
Two new steroidal glycosides (1-2) were isolated from the roots of Reineckia carnea, together with three known compounds (3-5). Their structures were determined on the basis of chemical methods and spectral data. Compounds 1-2 were the unique steroidal glycosides possessing structural feature of 14α-hydroxy-5β-steroids, and compounds 4-5 were isolated from R. carnea for the first time. The isolated compounds (1-5) were tested in vitro for their cytotoxic activities against the A549, HepG 2 and Caski cancer cell lines...
September 28, 2016: Fitoterapia
Miao He, Jia-Wei Min, Wei-Lin Kong, Xiao-Hua He, Jun-Xu Li, Bi-Wen Peng
Vitexin and isovitexin are active components of many traditional Chinese medicines, and were found in various medicinal plants. Vitexin (apigenin-8-C-glucoside) has recently received increased attention due to its wide range of pharmacological effects, including but not limited to anti-oxidant, anti-cancer, anti-inflammatory, anti-hyperalgesic, and neuroprotective effects. Isovitexin (apigenin-6-C-glucoside), an isomer of vitexin, generally purified together with vitexin, also exhibits diverse biological activities...
September 28, 2016: Fitoterapia
Wei Li, Lan-Lan Lou, Jian-Yong Zhu, Jun-Sheng Zhang, An-An Liang, Jing-Mei Bao, Gui-Hua Tang, Sheng Yin
Five new lanostane-type triterpenoids, ganoderenses A-E (1-5), two new lanostane nor-triterpenoids, ganoderenses F and G (6 and 7), along with 13 known analogues (8-20) were isolated from the fruiting body of Ganoderma hainanense. Their structures were determined by combined chemical and spectral methods, and the absolute configurations of compounds 1 and 13 were confirmed by single crystal X-ray diffraction. All compounds were evaluated for inhibitory activity against thioredoxin reductase (TrxR), a potential target for cancer chemotherapy with redox balance and antioxidant functions, but were inactive...
September 28, 2016: Fitoterapia
Feng-Qing Xu, Ning Wang, Wei-Wei Fan, Cheng-Ting Zi, Hong-Su Zhao, Jiang-Miao Hu, Jun Zhou
Four new cycloartane triterpenoids, 1α,3β-dihydroxy-16-keto-24(31)-en-cycloartane (1), 31-methoxyl-passifloic acid (2), cyclopassifloside XIV (3), and cyclopassifloside XV (4), together with six known compounds (5-10) were isolated from Passiflora edulis Sims. Their structures were elucidated on the basis of extensive spectroscopic analysis. All the compounds were evaluated for protective effects against damage of PC12 cell induced by glutamate according to traditional usage of the herbal medicine, and the results indicated that cycloartane triterpenoids maybe one of the active compositions of P...
September 27, 2016: Fitoterapia
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