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Acta Medica Iranica

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https://www.readbyqxmd.com/read/28282721/ethical-issues-surrounding-personalized-medicine-a-literature-review
#1
Pooneh Salari, Bagher Larijani
More than a decade ago, personalized medicine was presented in modern medicine. Personalized medicine means that the right drug should be prescribed for the right patient based on genetic data. No doubt is developing medical sciences, and its shift into personalized medicine complicates ethical challenges more than before. In this review, we categorized all probable ethical considerations of personalized medicine in research and development and service provision. Based on our review, extensive changes in healthcare system including ethical changes are needed to overcome the ethical obstacles including knowledge gap and informed consent, privacy and confidentiality and availability of healthcare services...
March 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/28282720/precision-medicine-approach-to-anaplastic-thyroid-cancer-advances-in-targeted-drug-therapy-based-on-specific-signaling-pathways
#2
Hilda Samimi, Parviz Fallah, Alireza Naderi Sohi, Rezvan Tavakoli, Mahmood Naderi, Masoud Soleimani, Bagher Larijani, Vahid Haghpanah
Personalized medicine is a set of diagnostic, prognostic and therapeutic approaches in which medical interventions are carried out based on individual patient characteristics. As life expectancy increases in developed and developing countries, the incidence of diseases such as cancer goes up among people in the community. Cancer is a disease that the response to treatment varies from one person to another and also it is costly for individuals, families, and society. Among thyroid cancers, anaplastic thyroid carcinoma (ATC) is the most aggressive, lethal and unresponsive form of the disease...
March 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/28282719/pharmacogenetics-and-personalized-medicine-in-pancreatic-cancer
#3
Ali Hosseini Bereshneh, Fatemeh Morshedi, Mahsa Hematyar, Arastoo Kaki, Masoud Garshasbi
 Pancreatic cancer (PC) is a progressive, fatal disease with a high degree of malignancy. More than 40000 peoplediefrom this cancer annually in the United States. As a multifactorial condition, PC has a complex nature, and there are several genes and signalingpathwaysimplicated in PC pathogenesis and progression. There are diffèrent mutations in master genesincludingtumorsuppressors and oncogenesthat lead to Pancreaticintraepithelialneoplasia (PanIN) whichis the mostcommon non-invasive precursorlesion of pancreatic cancer...
March 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/28282718/the-potential-of-circulating-tumor-cells-in-personalized-management-of-breast-cancer-a-systematic-review
#4
Fatemeh Khatami, Hamid Reza Aghayan, Maryam Sanaei, Ramin Heshmat, Seyed Mohammad Tavangar, Bagher Larijani
Circulating tumor cells (CTCs) recognition and characterization in the peripheral blood of patients with breast cancer have proven practical and predictive value in different studies. However, the clinical significance of CTCs enumeration and molecular characterization in thepersonalization of breast cancer diagnosis and treatment remains under the debate. A literature search in PubMed, Web of Science and Scopus was performed from October 1990 to June 2016 for studies which evaluating CTCs and its association with clinical and pathological characteristics and medical outcome in the field of breast cancer personalization for both diagnosis and treatment categories...
March 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/28282717/path-to-personalized-medicine-for-type-2-diabetes-mellitus-reality-and-hope
#5
Hamid Reza Aghaei Meybodi, Mandana Hasanzad, Bagher Larijani
Type 2 diabetes mellitus (T2DM) is recognized as a public health problem and increasingly prevalent illness. Key elements of the guideline for diabetes care are based on evidence-based medicine approach and apply for population, not individuals. However, individualized care can improve diabetes management. Personalized medicine is otherwise called precision medicine tries to find better prediction, prevention, and intervention for T2DM individuals. Precision medicine in diabetes refers to the utility of genomics data of a patient with diabetes to provide the most effective diagnosis strategies and treatment plans...
March 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/28282716/personalized-medicine-pharmacogenomics-and-drug-development
#6
Somayeh Mirsadeghi, Bagher Larijani
Personalized medicine aims is to supply the proper drug to the proper patient within the right dose. Pharmacogenomics (PGx) is to recognize genetic variants that may influence drug efficacy and toxicity. All things considered, the fields cover a wide area, including basic drug discovery researches, the genetic origin of pharmacokinetics and pharmacodynamics, novel drug improvement, patient genetic assessment and clinical patient administration. At last, the objective of Pharmacogenomics is to anticipate a patient's genetic response to a particular drug as a way of presenting the best possible medical treatment...
March 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/28282715/personalized-regenerative-medicine
#7
Babak Arjmand, Parisa Goodarzi, Fereshteh Mohamadi-Jahani, Khadijeh Falahzadeh, Bagher Larijani
Personalized medicine as a novel field of medicine refers to the prescription of specific therapeutics procedure for an individual. This approach has established based on pharmacogenetic and pharmacogenomic information and data. The terms precision and personalized medicines are sometimes applied interchangeably. However, there has been a shift from "personalized medicine" towards "precision medicine". Although personalized medicine emerged from pharmacogenetics, nowadays it covers many fields of healthcare...
March 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/28282714/personalized-medicine-a-new-era-in-endocrinology
#8
Babak Arjmand, Bagher Larijani
No abstract text is available yet for this article.
March 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/28282713/treatment-of-an-early-kaposi-s-sarcoma-case-post-kidney-transplantation-by-sirolimus-a-case-report
#9
Farzaneh Najafi, Parichehr Kafaie, Hossein Neamatzadeh
Kaposi᾽s sarcoma (KS) can develop in 0.06% to 4.1% of kidney transplant recipients. Here we describe a case of 50-year-old man who developed KS a few months after kidney transplantation. After transplantation, he had delayed graft function and was managed by anti-thymocyte globulin (ATG) for five days. At the discharge, his immunosuppressive therapy was prednisolone 20 mg/day, tTacrolimus (Pprograf®) 4 mg/day, and mycophenolate mofetil (MMF) 2 gr/day, while he also took Vvalcyte and diltiazem. Once diagnosed with KS, the Prograf® (tacrolimus)  was replaced by prednisolone (5 mg/day) and sirolimus (2 mg/day)...
February 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/28282712/a-patient-with-desmoid-tumors-and-familial-fap-having-frame-shift-mutation-of-the-apc-gene
#10
Sanambar Sadighi, Mahsa Ghaffari-Moghaddam, Mojtaba Saffari, Mohammad Ali Mohagheghi, Reza Shirkoohi
Desmoids tumors, characterized by monoclonal proliferation of myofibroblasts, could occur in 5-10% of patients with familial adenomatous polyposis (FAP) as an extra-colonic manifestation of the disease. FAP can develop when there is a germ-line mutation in the adenomatous polyposis coli gene. Although mild or attenuated FAP may follow mutations in 5΄ extreme of the gene, it is more likely that 3΄ extreme mutations haveamore severe manifestation of thedisease. A 28-year-old woman was admitted to the Cancer Institute of Iran with an abdominal painful mass...
February 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/28282711/abdominal-pain-as-extrapulmonary-presentation-of-pneumonia-in-an-adult-a-case-report
#11
Hamid Emadi Koochak, Elnaz Tabibian, Shahram Rahimi Dehgolan
Pneumonia is considered as the main cause of abdominal pain in children whereas it presents mostly by respiratory symptoms in adults. Here we present a 71-year-old Iranian female who complained specifically of abdominal pain on admission to our emergency department. We had found nothing as an etiology in our first evaluations. After several hours chest pain was added to the symptoms and the following chest, X-Ray showed a consolidation in the right lung base. She was treated by pneumonia antibiotic regimen and discharged after seven days in a good clinical condition...
February 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/28282710/early-onset-friedreich-s-ataxia-with-oculomotor-apraxia
#12
Amene Saghazadeh, Sina Hafizi, Firouzeh Hosseini, Mahmoud Reza Ashrafi, Nima Rezaei
Friedreich's ataxia (FRDA) is a rare autosomal recessive spinocerebellar ataxia which in the majority of cases is associated with a GAA-trinucleotide repeat expansion in the first intron of Frataxin gene located on chromosome 9. The clinical features include progressive gait and limb ataxia, cerebellar dysarthria, neuropathy, optic atrophy, and loss of vibration and proprioception. Ataxia with ocular motor apraxia type 1 (AOA1) is another autosomal recessive cerebellar ataxia which is associated with oculomotor apraxia, hypoalbuminaemia, and hypercholesterolemia...
February 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/28282709/analysis-of-saccular-function-with-vestibular-evoked-myogenic-potential-test-in-meniere-s-disease
#13
Sasan Dabiri, Nasrin Yazdani, Mahdis Esfahani, Niloufar Tari, Susan Adil, Zahra Mahvi, Nima Rezazadeh
Meniere's disease is the disorder of inner ear characterized by vertigo, tinnitus and sensorineural hearing loss. The vestibular evoked myogenic potential (VEMP) test could be useful in the analysis of saccular function, and diagnosis of Meniere's disease. In this study, we've analyzed the saccular function, using VEMP test in different groups of Meniere's disease. Patients were categorized as possible, probable or definite Meniere's disease groups according to the guideline of American Academy of Otolaryngology-Head and Neck Surgery...
February 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/28282708/postural-control-in-deaf-children
#14
Amir-Abbas Ebrahimi, Guita Movallali, Ali-Ashraf Jamshidi, Mehdi Rahgozar, Hojjat Allah Haghgoo
This cross-sectional study aimed to determine the reliability of static control evaluation with Synapsys Posturography System (SPS, Marseille, France) and to compare the static postural control of deaf children with typically developing children. This study was conducted in 2 phases on 81 children of 7 to 12 years old in Tehran schools. The first phase examined the reliability of static balance evaluation with SPS. In this phase, a total of 12 children with typical development were evaluated and then do a re-test 1 week later...
February 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/28282707/post-partum-depression-effect-on-child-health-and-development
#15
Fatemeh Abdollahi, Farideh Rezai Abhari, Mehran Zarghami
While studies have shown the disastrous effects of post-partum depression (PPD) on children's behaviors, there is relatively lack of reliable data in Asian countries. This study examined the relative significance of maternal PPD in children's developmental disabilities at age four. In a longitudinal study design (2009), 1801 pregnant women attending in primary health centers of Mazandaran province in the north of Iran provided self-reports of depression from two to twelve postpartum weeks using Edinburgh Postnatal Depression Scale (EPDS)...
February 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/28282706/cardiovascular-malformations-in-infants-of-diabetic-mothers-a-retrospective-case-control-study
#16
Parvin Akbariasbagh, Mamak Shariat, Naseredin Akbariasbagh, Bita Ebrahim
Maternal diabetes has teratogenic effects on the evolution of the fetal cardiovascular system; as a consequence, cardiovascular malformations are the most common anomalies in infants of diabetic mothers. The present study focuses on the association of all types of diabetes in mothers with the incidence of congenital cardiovascular malformations in their infants. In this retrospective case-control study performed between the years 2008 and 2010, 35 infants of diabetic mothers were selected as a case group, and another 35 infants of mothers with normal blood glucose levels were selected as a control group...
February 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/28282705/study-of-serum-uric-acid-levels-in-myocardial-infarction-and-its-association-with-killip-class
#17
Maryam Mehrpooya, Farnoosh Larti, Younes Nozari, Roya Sattarzadeh-Badkoobeh, Amir Farhang Zand Parsa, Jayran Zebardast, Anahita Tavoosi, Fatemeh Shahbazi
The present study aimed to compare the serum level of uric acid in patients with and without heart failure and also to determine the association between uric acid level and clinical status by Killip class in patients with STEMI. This case-control study was conducted on 50 consecutives as control group and 50 patients with acute heart failure, (20 patients had acute STEMI), who documented by both clinical conditions and echocardiography assessment. The mean plasma level of uric acid in the case group was 7.6±1...
February 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/28282704/comparison-of-bone-density-of-distal-radius-with-hip-and-spine-using-dxa
#18
Leila Amiri, Azita Kheiltash, Shafieh Movassaghi, Maryam Moghaddassi, Leila Seddigh
Osteoporosis diagnosis is usually based on examination of the hip bone and vertebrae density; however, the radius bone has gained attention recently in terms of feasibility and accessibility as it is done by portable devices with proper precision. This study aims to compare hip and spine density with radius, knowing whether radius may be an appropriate alternative for osteoporosis diagnosis. 120 females who were referred to one Densitometry Center checked their skeletal status using a hologic unit for densitometry of spine, femoral neck, and one-third radius...
February 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/28282703/vapocoolant-spray-effectiveness-on-arterial-puncture-pain-a-randomized-controlled-clinical-trial
#19
Shervin Farahmand, Hadi Mirfazaelian, Mojtaba Sedaghat, Assieh Arashpour, Morteza Saeedi, Shahram Bagheri-Hariri
Arterial blood gas (ABG) sampling is a painful procedure with no perfect technique for quelling the discomfort. An ideal local anesthesia should be rapid, easy to learn, inexpensive, and noninvasive. This study was aimed to compare pain levels from ABG sampling performed with vapocoolant spray in comparison to placebo. We hypothesized that pretreatment with the vapocoolant would reduce the pain of arterial puncture by at least 1 point on a 10 point verbal numeric scale. We have evaluated the effectiveness of a vapocoolant spray in achieving satisfactory pain control in patients undergoing ABG sampling in this randomized placebo controlled trial...
February 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/28282702/a-theory-towards-a-measurable-definition-for-health-introducing-two-variables
#20
Hila Yousefi, Nima Rezaei
No abstract text is available yet for this article.
February 2017: Acta Medica Iranica
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