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Acta Medica Iranica

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https://www.readbyqxmd.com/read/29436799/-eye-of-the-tiger-in-a-non-responsive-neuropsychiatric-patient-a-case-report
#1
Milad Hosseinialhashemi, Babak Daneshfard, Atefe Hashemi
Hallervorden-Spatz syndrome is a rare neurodegenerative disorder with hereditary properties. It usually occurs in young adolescents with extrapyramidal symptoms besides disturbed mental function. In this study, we present a 23-year-old neuropsychiatric patient who primarily misdiagnosed to have conversion disorder. She had 5-year history of progressive dysarthria and generalized abnormal movements. After detecting the pathognomonic sign of "eye of the tiger" diagnosis was confirmed. The patient was discharged...
January 2018: Acta Medica Iranica
https://www.readbyqxmd.com/read/29436798/a-road-to-the-heart-from-uterine-closet-a-case-report
#2
Aghygh Heidari, Samsam Dabiri, Feridoun Sabzi
Angiosarcomas of the uterine is a malignant and poor prognostic tumor and can either be a primary sarcoma or arising secondary to radiotherapy of a more complex tumor. Primary uterine angiosarcomas are exceptional and probably arise from embryonic vascular remnants, teratoma or from the rich uterine vasculature. We reported a rare case of primary angiosarcoma of uterine that at the time of diagnosis presented with sign and symptom of local and distant metastasis. The patient presented with dyspnea, chest pain, and history of vaginal bleeding and pelvic pain...
January 2018: Acta Medica Iranica
https://www.readbyqxmd.com/read/29436797/a-case-of-kleine-levin-syndrome-diagnostic-and-therapeutic-challenge
#3
Marino Marčić, Ljiljana Marčić, Marina Titlić
Kleine-Levin syndrome (KLS) is a rare sleep disorder mainly affecting teenage boys in which the main features are intermittent hypersomnolence, behavioral and cognitive disturbances, hyperphagia, and in some cases hyper sexuality. Etiology is unknown, and there is no specific clinical or imaging test for this syndrome even though the illness has well-defined clinical features. Also, there is no effective treatment for KLS. KLS is self-limited, so the prognosis for these patients is not so bad. This study presents our case report and comprehensive workout that led to diagnosis which is primarily clinical...
January 2018: Acta Medica Iranica
https://www.readbyqxmd.com/read/29436796/predictive-value-of-braden-risk-factors-in-pressure-ulcers-of-outpatients-with-spinal-cord-injury
#4
Fariba Sadeghi Fazel, Nazi Derakhshanrad, Mir Saeed Yekaninejad, Fardis Vosoughi, Asal Derakhshanrad, Hooshang Saberi
Pressure Ulcers (PUs) remain among the most common complications after traumatic spinal cord Injuries (SCIs). The main goal of risk factor assessment with different tools has been to provisionally estimate the chance of developing pressure ulcers in patients with Spinal Cord Injury (SCI). Braden tool has been of good predictive value and most commonly employed in hospital communities for risk assessment of pressure sore development. The objective of this study was to determine the Braden risk factors as well as the prevalence of pressure injuries in SCI patients...
January 2018: Acta Medica Iranica
https://www.readbyqxmd.com/read/29436795/assessing-the-phenylketonuria-screening-program-in-newborns-iran-2015-2016
#5
Foruzan Ganji, Hooshang Naseri, Noushin Rostampour, Mozhde Sedighi, Masoud Lotfizadeh
Phenylketonuria is one of the most important congenital disorders and an autosomal recessive metabolic disease that can cause irreversible brain damages, mental retardation, and cognitive disorders if left untreated. In order to reduce the genetic abnormalities caused by this metabolic disease, screening programs are implemented. The quality of the program must be properly assessed to achieve the objectives of this program if promoting children's health is of concern. The descriptive-analytic method is adopted here to assess the phenylketonuria screening program in practice in Chaharmahal and Bakhtiari province since 2012 and analyze the incidence and program coverage...
January 2018: Acta Medica Iranica
https://www.readbyqxmd.com/read/29436794/the-follow-up-role-of-the-vestibular-evoked-myogenic-potential-test-in-meniere-s-disease
#6
Nasrin Yazdani, Farzaneh Nejadian, Nima Rezazadeh, Reza Hoseinabadi, Ebrahim Karimi, Reza Gharibi, Sasan Dabiri
Despite some proposed roles for the diagnostic impact of the cervical vestibular evoked myogenic potential test in the patients with Meniere's disease, the role of this test as an objective instrument in following up the patients with Meniere's disease who underwent. Intratympanic steroid injection is not cleared. In a prospective study, thirty-one adult patients with definite one-sided Meniere's disease with vertigo as main complaint refractory to medical treatments for three months, were selected. Patients underwent three times of intratympanic dexamethasone injection with one-week intervals...
January 2018: Acta Medica Iranica
https://www.readbyqxmd.com/read/29436793/gonadotropin-regulation-of-retinoic-acid-activity-in-the-testis
#7
Seyedmehdi Nourashrafeddin, Batool Hosseini Rashidi
Initiation of spermatogenesis in primates is triggered at puberty by an increase in gonadotropins; i.e., follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Prior to puberty, testis of the monkey contains only undifferentiated germ cells. However, sermatogonial differentiation and spermatogenesis may be initiated prior to puberty after stimulation with exogenous LH and FSH. Retinoic acid (RA) signaling is considered to be a major component that drives spermatogonial differentiation. We were interested in evaluating the relative role of LH and FSH, either alone or in combination, in regulating the retinoic acid signaling in monkey testis...
January 2018: Acta Medica Iranica
https://www.readbyqxmd.com/read/29436792/wharton-s-jelly-derived-mesenchymal-stem-cells-isolation-and-characterization
#8
Hossein Ranjbaran, Saeid Abediankenari, Masoud Mohammadi, Narjes Jafari, Alireza Khalilian, Zahra Rahmani, Marzei Momeninezhad Amiri, Pirooz Ebrahimi
Wharton`s jelly-derived mesenchymal stem cells (WJ-MSCs), have a high proliferation valency and they do not produce teratogen or carcinogen after subsequent transplantation. They are known as regenerative medicine. Thus more research is needed on the isolation and characterization of mesenchymal stem cells. In this experimental study, we obtained Wharton's jelly tissues from mothers during normal vaginal delivery, after obtaining their informed consent. Mesenchymal stem cells were isolated from cultured Wharton`s jelly, cultured, and were then examined for their proliferation, immunophenotypes, and differentiation capacities...
January 2018: Acta Medica Iranica
https://www.readbyqxmd.com/read/29436791/promoter-hypermethylation-of-the-eyes-absent-4-gene-is-a-tumor-specific-epigenetic-biomarker-in-iranian-colorectal-cancer-patients
#9
Matineh Barati Bagerabad, Sahar Tavakolian, Mohammad Reza Abbaszadegan, Mohammad Amin Kerachian
The aim of this study was to investigate whether hypermethylation of Eyes Absent 4 (EYA4) is also implicated in Iranian Colorectal Cancer (CRC) patients or not. From fresh frozen tissues, samples from 38 paired (cancer and normal) CRC tissue specimens were used in this study, the DNA was isolated, sodium bisulfite treated and analyzed by methylation-specific polymerase (MSP) chain reaction using primers specific for unmethylated or methylated promoter sequences of the EYA4 gene. We also analyzed EYA4 mRNA expression using real time RT-PCR...
January 2018: Acta Medica Iranica
https://www.readbyqxmd.com/read/29436790/cromakalim-a-potassium-channel-opener-ameliorates-the-organophosphate-and-carbamate-induced-seizure-in-mice
#10
Sattar Ostadhadi, Abouzar Moradi, Samira Zolfaghari, Vahid Nikoui, Ahmad Reza Dehpour
Organophosphates (OPs) and carbamates are acetylcholine esterase inhibitors (AChEIs), which can cause seizure and lethality. Anticonvulsant properties of potassium channel openers including cromakalim have been determined in previous studies. In the present experiment, the possible effect of cromakalim on the convulsion and death induced by OPs and carbamates was studied in mice. Dichlorvos (an OP, 50 mg/kg) and physostigmine (a carbamate, 2 mg/kg) were used to induce seizure in animals. Cromakalim at doses of 0...
January 2018: Acta Medica Iranica
https://www.readbyqxmd.com/read/29436789/evaluation-of-chronic-losartan-treatment-effect-on-cardiac-chronotropic-dysfunction-in-biliary-cirrhotic-rats
#11
Farahnaz Jazaeri, Razieh Afsharmoghaddam, Alireza Abdollahi, Giti Ghamami, Ahmad Reza Dehpour
Cirrhosis is associated with cardiac chronotropic and inotropic dysfunction which is known as cirrhotic cardiomyopathy. Cardiac responsiveness to adrenergic stimulation is impaired in cirrhosis. Moreover, there is vagal nerve dysfunction which is related to neuromodulatory dysfunction of the angiotensin II in the cirrhosis. This study was aimed to explore the hypothesis that administration of Losartan-angiotensin II receptor antagonist increases cardiac chronotropic response to isoproterenol in cirrhotic rats; and if so, whether this is associated with altered cardiac TGF-β receptor expression...
January 2018: Acta Medica Iranica
https://www.readbyqxmd.com/read/29436788/universal-scientific-education-and-research-network-usern-twinkling-stars-unite-to-make-the-world-glow
#12
Nima Rezaei
No abstract text is available yet for this article.
January 2018: Acta Medica Iranica
https://www.readbyqxmd.com/read/29373889/paraplegia-after-off-pump-coronary-artery-by-pass-grafting
#13
Aghigh Haidari, Feridoun Sabzi, Samsam Dabiri
Paraplegia is an exceedingly rare neurologic complication after off-pump coronary artery bypass graft (OPCAB) surgery commonly caused by spinal cord ischemia (SCI). SCI is not a well unknown clinical phenomenon in the postoperative course. SCI has been reported after noncardiac surgery in otherwise healthy subjects in whom only one risks factor i.e. severe hypotension has been documented. SCI has also been reported as a rare complication among the other neurologic sequels of cardiac surgery. We report a case of paraplegia in a patient with metabolic syndrome and multiples risk factors after an OPCAB...
December 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/29373888/sarcoid-myopathy-mimicking-polymyositis-a-case-report-and-pool-analysis-of-the-literature-reviews
#14
REVIEW
Syahrul Sazliyana Shaharir, Adawiyah Jamil, Sumitro Kosasih, Low Soo Fin, Radhika Sridharan, Suria Hayati Md Pauzi
A 59-year-old man presented with proximal myopathy, myalgia, and weight loss, with the initial markedly elevated serum creatine kinase at 11,000 U/L. Due to his refusal for muscle biopsy, he was initially treated as inflammatory myositis and responded well with the corticosteroids. However, he subsequently had a relapse of the symptoms with more extensive systemic involvement, i.e., hypercalcemia, lymphadenopathy and subcutaneous nodules. Finally, a biopsy of the thigh and subcutaneous nodule revealed non-caseating granulomatous inflammation, consistent with sarcoidosis...
December 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/29373887/chondrosarcoma-in-metachondromatosis-a-rare-case-report
#15
Khodamorad Jamshidi, Tina Shooshtarizadeh, Mehrdad Bahrabadi
Metachondromatosis which was first described in 1971 by Maroteaux is a rare genetic disease consisting of osteochondromas and enchondromas, caused by loss of function of the PTPN11 gene. It is distinct from other cartilaginous tumors such as multiple osteochondromas and hereditary multiple exostosis by the distribution and orientation of lesions, and pattern of inheritance. In Metachondromatosis osteochondromas typically occur in hands, feet, femur, and tibia while enchondromas commonly affect the pelvic bones and femurs...
December 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/29373886/the-neuroprotective-effects-of-flaxseed-oil-supplementation-on-functional-motor-recovery-in-a-model-of-ischemic-brain-stroke-upregulation-of-bdnf-and-gdnf
#16
Abolqasem Bagheri, Sahand Talei, Negar Hassanzadeh, Tahmineh Mokhtari, Mohammad Akbari, Fatemeh Malek, Seyed Behnamedin Jameie, Yousef Sadeghi, Gholamreza Hassanzadeh
Cerebral ischemic stroke is a common leading cause of disability. Flaxseed is a richest plant-based source of antioxidants. In this study, the effects of flaxseed oil (FSO) pretreatment on functional motor recovery and gene expression and protein content of neurotrophic factors in motor cortex area in rat model of brain ischemia/reperfusion (I/R) were assessed. Transient middle cerebral artery occlusion (tMCAo) in rats was used as model brain I/R. Rats (6 in each group) were randomly divided into four groups of Control (Co+normal saline [NS]), Sham (Sh+NS), tMCAo+NS and tMCAo+FSO...
December 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/29373885/the-effect-of-rosa-damascena-extract-on-expression-of-neurotrophic-factors-in-the-ca1-neurons-of-adult-rat-hippocampus-following-ischemia
#17
Seyedeh Farzaneh Moniri, Azim Hedayatpour, Gholamreza Hassanzadeh, Mahdi Vazirian, Morteza Karimian, Maryam Belaran, Shahram Ejtemaie Mehr, Mohamad Akbari
Ischemic stroke is an important cause of death and disability in the world. Brain ischemia causes damage to brain cell, and among brain neurons, pyramidal neurons of the hippocampal CA1 region are more susceptive to ischemic injury. Recent findings suggest that neurotrophic factors protect against ischemic cell death. A dietary component of Rosa damascene extract possibly is associated with expression of neurotrophic factors mRNA following ischemia, so it can have therapeutic effect on cerebral ischemia. The present study attempts to evaluate the neuroprotective effect of Rosa damascene extract on adult rat hippocampal neurons following ischemic brain injury...
December 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/29373884/effect-of-progesterone-on-latent-phase-prolongation-in-patients-with-preterm-premature-rupture-of-membranes
#18
RANDOMIZED CONTROLLED TRIAL
Fatemeh Abdali, Simin Taghavi, Shabnam Vazifekhah, Mohammad Naghavi Behzad, Mohammad Mirza Aghazadeh Attari
Preterm premature rupture of membranes (PPROM) is a condition leading to an increased risk of maternal and neonatal morbidity and mortality in pregnant women. To prevent this complication, some studies have proposed using prophylactic progesterone. However, due to lack of sufficient relevant data, there is still need for further studies in this regard. This study was performed to determine the effect of rectal progesterone on the latent phase and maternal and neonatal outcome variables in females with PPROM...
December 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/29373883/the-relation-of-carotid-arteries-intima-media-thickness-with-snoring-and-obstructive-sleep-apnea-in-type-2-diabetes-patients
#19
Leila Ghofraniha, Mahnaz Amini, Yasamin Davoudi, Saeed Eslami, Parvin Layegh, Zahra Lotfi, Farnoush Firouzi, Samaneh Khajehnasiri
In recent decades, the relation of carotid artery intima-media thickness (IMT) as a marker of atherosclerosis with snoring and sleep disorders has been drawing attention. The aim of this study was to evaluate the relation of carotid arteries IMT with snoring in type 2 diabetic patients. This cross-sectional study was performed on type 2 diabetes patients referring to Mashhad University of Medical Sciences' clinics. The stop Bang, Epworth sleepiness scale, and Stanford questionnaires were used for evaluation of daily sleepiness and snoring...
December 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/29373882/the-association-between-bisphenol-a-and-polycystic-ovarian-syndrome-a-case-control-study
#20
Batool Hossein Rashidi, Massoud Amanlou, Tahere Behrouzi Lak, Mahya Ghazizadeh, Fedyeh Haghollahi, Maryam Bagheri, Bita Eslami
Polycystic ovarian syndrome (PCOS) is an endocrine metabolic disorder with unclear etiopathogenesis among reproductive age women. Evidences show genetic susceptibility and environmental factors were associated with PCOS. The aim of this study was to find the association between urinary concentrations of Bisphenol-A as an endocrine disrupting chemical (EDC) and PCOS. A case-control study was conducted in 51 samples in each group. All cases were selected from women who diagnosed with PCOS at Gynecology and infertility center...
December 2017: Acta Medica Iranica
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