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Veterinary Clinical Pathology

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https://www.readbyqxmd.com/read/30422334/effect-of-racing-on-blood-variables-in-standardbred-horses
#1
Astrid Bos, Ellen Compagnie, Arno Lindner
BACKGROUND: Blood is collected for hematologic and biochemical analyses when racehorses perform poorly. However, racing affects most analyte levels; therefore, the timing of blood sampling can affect analyte levels and interpretations. OBJECTIVE: This study aimed to determine if the blood variable levels returned to pre-racing levels 2 and 3 days post-racing. METHODS: Blood was sampled from 17 healthy racehorses pre- and post-racing. The variables measured from plasma were albumin, cholesterol, creatinine, calcium (Ca), phosphorus (P), magnesium (Mg), sodium (Na), potassium (K), creatine phosphokinase (CK), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), gamma-glutamyl transferase (GGT), and cortisol...
November 13, 2018: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/30415503/basal-cell-enumeration-does-not-predict-malignancy-in-canine-perianal-gland-tumor-cytology
#2
Samantha J M Evans, Sara L Connolly, Paula A Schaffer, Miranda D Vieson, Amanda Stiles, A Russell Moore
BACKGROUND: Perianal (hepatoid) gland tumors are common in dogs, and the distinction between the benign and malignant forms is clinically important. Cytology of these tumors typically contains many large hepatoid cells and fewer small basal cells. OBJECTIVES: The objective of this study was to determine whether the proportion of the smaller basaloid reserve cells in cytologic samples from perianal tumors correlates with malignancy. METHODS: Eighty-three cases of cytologically diagnosed perianal gland tumors with corresponding histopathologic sections were identified from two separate institutions and included six (7...
November 11, 2018: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/30403420/validation-of-an-elisa-for-detection-of-neutrophil-gelatinase-associated-lipocalin-ngal-in-equine-serum
#3
Stine Jacobsen, Lise C Berg, Emil Tvermose, Malene B Laurberg, Gaby van Galen
BACKGROUND: Neutrophil gelatinase-associated lipocalin (NGAL) has been shown to be a useful marker of kidney injury in people and dogs, but has not been described in horses. OBJECTIVES: The aim of the study was to validate a commercially available porcine-specific ELISA to measure serum concentrations of equine NGAL. METHODS: Intra- and interassay imprecisions were evaluated by multiple measurements on equine serum pools. Assay inaccuracy was determined by the linearity under dilution...
November 7, 2018: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/30379340/diagnosis-of-feline-mesenchymal-nasal-hamartoma-by-squash-preparation-cytology
#4
Enrico Bottero, Maverick Melega, Erika R Dimartino, Michele Tricarico, Elvio Lepri, Davide De Lorenzi, Barbara Miniscalco, Fulvio Riondato
BACKGROUND: Feline Mesenchymal Nasal Hamartoma (MNH) is a rare benign tumor-like lesion of the sinonasal tract affecting young cats. OBJECTIVES: This study aimed to determine the diagnostic significance of osteoblast-like (OB-L) and osteoclast-like cells (OC-L) in squash preparation cytology from endoscopic biopsies. METHODS: A 5-year database was retrospectively reviewed and included 109 cases of which 24 were diagnosed as MNH by histopathology...
October 31, 2018: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/30371958/what-is-your-diagnosis-dermal-mass-over-the-ribs-with-metastasis-to-lymph-nodes-in-a-dog
#5
Courtney Nelson, Anne Barger, Patrick Roady
No abstract text is available yet for this article.
October 29, 2018: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/30358180/validation-of-an-immunocytochemical-assay-for-immunophenotyping-of-lymphoma-in-guinea-pigs-cavia-porcellus
#6
Samantha J M Evans, Kendal E Harr, Lauren Thielen, Amy L MacNeill
BACKGROUND: Lymphoma is an important disease of pet guinea pigs, although validation of immunophenotyping techniques based on cytologic or hematologic samples has not been reported. OBJECTIVE: To describe an immunocytochemical method for immunophenotyping of lymphoma (as either T- or B-cell) in guinea pigs, and to validate antibodies for this purpose. METHODS: Blood and tissues were obtained at the time of necropsy from laboratory guinea pigs and a privately owned dog (control) euthanized for reasons unrelated to lymphoproliferative disease...
October 25, 2018: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/30347120/metastatic-disease-in-a-dog-with-a-well-differentiated-perianal-gland-tumor
#7
Maggie R McCourt, Greg M Levine, Melanie A Breshears, Corey R Wall, James H Meinkoth
Fine-needle aspirates from a perianal mass on an 8-year-old, intact male, Miniature Poodle presenting for tenesmus showed a uniform population of well-differentiated hepatoid cells with no notable criteria of malignancy. The cytologic diagnosis was a perianal gland tumor, with adenoma likely given the cytomorphology. The abdominal ultrasound revealed multiple, markedly enlarged, intra-abdominal lymph nodes. LN aspirates also showed well-differentiated polygonal, hepatoid cells displaying no notable cellular atypia...
October 22, 2018: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/30347113/what-is-your-diagnosis-submandibular-mass-in-a-dog
#8
Julie Allen, Ashley M Talley, Carol B Grindem, Jennifer A Neel
No abstract text is available yet for this article.
October 22, 2018: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/30335199/hematologic-and-biochemical-reference-intervals-in-shetland-sheepdogs
#9
Beatrice Ruggerone, Marco Giraldi, Saverio Paltrinieri, Paola Scarpa
BACKGROUND: Several breeds have physiological peculiarities that induce variations in reference intervals (RIs) compared with the general canine population. Shetland sheepdogs (SSs) are reported to be more predisposed to different diseases (eg, hyperlipidemia, gallbladder mucocele, and hypothyroidism). Consequently, a breed-specific approach is more often required. OBJECTIVES: The aim of this study was to determine whether the RIs of the general canine population could be applied to that of SSs, and to generate breed-specific RIs, where appropriate...
October 18, 2018: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/30325547/effects-of-storage-conditions-on-two-platelet-agonists-for-whole-blood-impedance-platelet-aggregometry-in-dogs
#10
Sarah B Shropshire, Christine S Olver
BACKGROUND: Whole blood impedance platelet aggregometry (Multiplate-) can be performed with different agonists to evaluate platelet function. Although the manufacturer recommends disposal of stored reagents after 1 month at -20°C or 24 hours at 4°C, reagent integrity after reconstitution under different storage conditions is unknown. If reagent integrity is stable for longer periods, assay costs could decrease dramatically. OBJECTIVES: This study aimed to determine the stability of reconstituted arachidonic acid (AA) and adenosine diphosphate (ADP) platelet agonists stored at -20°C and -80°C for up to 6 months...
October 16, 2018: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/30325526/what-is-your-diagnosis-splenic-aspirate-from-a-dog
#11
Julie Allen, Ashley N Hartley, Jennifer A Neel
No abstract text is available yet for this article.
October 16, 2018: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/30321471/klossiella-equi-infection-in-a-cheval-canadien-mare
#12
Rose E Baker, John W Schlipf, Jacqueline V Brady, M Elena Gorman
A 6-year-old Cheval Canadien mare was presented for clinical signs related to acute kidney injury after receiving a course of nonsteroidal anti-inflammatory therapy. Cytologic examination of concentrated urine revealed small protozoal organisms that were later identified as Klossiella equi. Both sporocysts and free-floating sporozoites were identified in the urine, which has not been previously documented. The mare responded well to intravenous fluid therapy, and as she regained tubular function, the presence of the protozoa in the urine also abated...
October 15, 2018: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/30321465/actinomadura-vinacea-isolated-from-a-nonhealing-cutaneous-wound-in-a-cat
#13
Bridgette Wells, Anne L Burnum, Juliet Armstrong, Susan Sanchez, James B Stanton, Melinda S Camus
A 6-year-old, spayed female, domestic shorthair cat was presented to the University of Georgia Veterinary Teaching Hospital for a 3-year history of a nonhealing wound on the right tarsus. The wound temporarily resolved with medical management, but intermittently recurred when antimicrobials were discontinued. At presentation, the wound had become refractory to antimicrobial therapy. Physical examination revealed a 1 cm diameter crust along the medial aspect of the right tarsus. Proximal to the crust, were 2 non-painful, fluctuant swollen areas that were free of drainage...
October 15, 2018: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/30240029/aldosterone-producing-adrenocortical-carcinoma-with-myxoid-differentiation-in-a-cat
#14
Charalampos Attipa, Samuel Beck, Victoria Lipscomb, Kate English, Sofia Carvalho, Matti Kiupel, Balázs Szladovits, Laureen M Peters
A 10-year-old male neutered Persian cat was presented with an abdominal mass and history of weakness. Blood smear examination found marked elliptocytosis, and serum biochemical analysis revealed hypokalemia, hypochloremia, increased creatine kinase activity, and a high aldosterone concentration. Cytologic examination of the mass revealed neoplastic endocrine cells with moderate criteria of malignancy, favoring adrenocortical neoplasia. The adrenal mass was surgically excised and histologically characterized by lobules of mildly pleomorphic, polygonal neoplastic cells with moderate to abundant, occasionally granular, eosinophilic cytoplasm...
September 21, 2018: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/30229963/a-case-of-canine-high-grade-t-cell-lymphoma-immunophenotypically-consistent-with-t-zone-lymphoma
#15
Cyril Parachini-Winter, Kaitlin M Curran, Duncan S Russell, Elena Gorman
A 9-year-old spayed female Curly Coated Retriever was referred for evaluation of generalized peripheral lymphadenomegaly. The dog was clinically healthy on presentation with no anomalies detected on complete blood count, serum biochemistry, urinalysis, or three-view thoracic radiographs. Fine-needle aspiration (FNA) and cytology of the peripheral lymph nodes were consistent with lymphoma with an intermediate-sized lymphoid population. Flow cytometry of peripheral lymph nodes was consistent with a homogeneous population of CD4+ T cells that had lost expression of the pan-leukocyte antigen CD45...
September 19, 2018: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/30152856/analytical-quality-goals-a-review
#16
REVIEW
Bente Flatland, Melinda S Camus, Randolph M Baral
Analytical quality goals indicate how laboratory tests must perform to be clinically useful for their intended purpose. These goals have historically focused on analytical error assessment for quantitative methods and vary with measurand concentration or activity, and species. Although formalized quality goal models have been developed in human medicine, quality goals in veterinary medicine, to date, have not been formalized; use of human regulatory-based goals, consensus-based goals, or biologic variation-based goals have been reported most often...
August 28, 2018: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/30199124/reference-intervals-for-coagulation-variables-in-healthy-adult-domestic-goats-capra-aegagrus-hircus
#17
Kristin M Zersen, A Russell Moore, Christine S Olver, Justin C Mathis
BACKGROUND: Coagulation has not been studied extensively in adult goats, and reference intervals (RIs) for coagulation variables have not yet been established and would be clinically useful. OBJECTIVES: The goal of this study was to establish coagulation variable RIs in adult goats for future coagulation interpretation. METHODS: Blood samples from 40 healthy adult goats were collected, and assays for PT, APTT, D-dimers, antithrombin III, and fibrinogen were performed...
September 2018: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/30199123/research-and-diagnostic-tool-the-symmetric-dimethylarginine-case-for-research-use-only
#18
LETTER
Pasquale Santoro
No abstract text is available yet for this article.
September 2018: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/30199122/data-not-shown-times-have-changed-in-scientific-publishing-and-at-the-veterinary-clinical-pathology-journal
#19
EDITORIAL
Wendy Sprague
No abstract text is available yet for this article.
September 2018: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/30199121/analytical-validation-of-platelet-microparticle-quantification-in-cats
#20
Signe E Cremer, Jørgen Koch, Nanna Graversen, Anne S Gravgaard, Rebecca Langhorn, Annemarie T Kristensen, Jakob L Willesen, Lise N Nielsen
BACKGROUND: Cardiogenic embolism (CE) in cats is a devastating condition primarily associated with hypertrophic cardiomyopathy (HCM). Hypercoagulability may pose a risk for thrombus formation; however, no single test can predict CE development. Platelet microparticles (PMPs) released from platelet membranes are associated with thrombosis in humans. OBJECTIVES: The aims were to validate flow cytometric PMP quantification in cats analytically and, in a pilot study, evaluate the procoagulant annexin V (AnV) positive PMP concentration in healthy cats and cats with asymptomatic HCM...
September 2018: Veterinary Clinical Pathology
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