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Inorganica Chimica Acta

Sara M Delgado-Rivera, Giovanny E Pérez-Ortiz, Andrés Molina-Villarino, Fabiel Morales-Fontán, Lyannis M García-Santos, Alma M González-Albó, Ana R Guadalupe, Ingrid Montes-González
A novel series of ferrocenyl chalcone ammonium and pyridinium salt derivatives were synthesized in order to improve their solubility in aqueous media. Substituted ferrocenyl chalcones with amines and pyridines were synthesized using the base-catalyzed Claisen-Schmidt reaction, and their corresponding salts were prepared by a nucleophilic quaternization reaction at the nitrogen atom. Most of the synthesized ferrocenyl chalcone salts were soluble in water at room temperature. They were fully characterized by IR, NMR spectroscopy and HRMS spectrometry, and their electrochemistry was studied...
November 1, 2017: Inorganica Chimica Acta
Alejandra Cruz-Montañez, Keyla F Morales-Rivera, Wildeliz Torres, Elizabeth M Valentín, Jaileen Rentas, José A Prieto
The enantioselective synthesis of polypropionates continues to be an attractive realm for the synthetic chemists mostly due to the challenges presented by the number of consecutive stereogenic centers contained within the aliphatic chain. Over the years, our laboratory has developed an epoxide-based three-step reiterative methodology for the construction of these targets, with the ultimate goal that the approach could be extended to the synthesis of polypropionate-containing natural products. The key steps include the diastereoselective epoxidation of allylic and homoallylic alcohols, and the regioselective cleavage of 2-methyl-3,4-epoxy alcohols...
November 1, 2017: Inorganica Chimica Acta
Marilyn García-Arriaga, Maxier Acosta-Santiago, Antony Cruz, José M Rivera-Rivera, Gustavo E López, José M Rivera
Guanosine and related derivatives self-assemble in the presence of cations like potassium into supramolecular G-quadruplexes (SGQs), where four guanine moieties form planar tetrads (T) that coaxially stack into columnar aggregates with broad size distributions. However, SGQs made from 8-aryl-2'-deoxyguanosine derivatives (8ArGs), form mostly octamers, or two-tetrad (2T)-SGQs, while some form dodecamers (3T-SGQs), or hexadecamers (4T-SGQs), and none reported to date form higher assemblies. A theoretical model that addresses the configurational space available for the multiple pathways available for 8ArGs to self-assemble into SGQs is used to frame a series of molecular dynamics simulations (MDS) with selected SGQs...
November 1, 2017: Inorganica Chimica Acta
Deidra L Gerlach, Sopheavy Siek, Dalton B Burks, Jamie M Tesh, Courtney R Thompson, Robert M Vasquez, Nicholas J White, Matthias Zeller, Douglas B Grotjahn, Elizabeth T Papish
We report the synthesis and characterization of new ruthenium(II) and iridium(III) complexes of a new bidentate chelate, NHCR'-pyOR (OR = OMe, OtBu, OH and R' = Me, Et). Synthesis and characterization studies were done on the following compounds: four ligand precursors (1-4); two silver complexes of these NHCR'-pyOR ligands (5-7); six ruthenium complexes of the type [η6-(p-cymene)Ru(NHCR'-pyOR)Cl]X with R' = Me, Et and R = Me, tBu, H and X = OTf-, PF6- and PO2F2- (8-13); and two iridium complexes, [Cp*Ir(NHCMe-pyOtBu)Cl]PF6 (14) and [Cp*Ir(NHCMe-pyOH)Cl]PO2F2 (15)...
September 1, 2017: Inorganica Chimica Acta
Jia Li, Monika A Molenda, Shannon M Biros, Richard J Staples, Ferman A Chavez
A new iron(II) complex has been prepared and characterized. [Fe(TrImA)2(OTf)2] (1, TrImA = 1-Tritylimidazole-4-carboxaldehyde). The solid state structure of 1 has been determined by X-ray crystallography. Compound 1 crystallizes in monoclinic space group P21/c, with a = 10.8323(18) Å, b = 8.1606(13) Å and c = 24.818(4) Å. The iron center is coordinated to two imidazole groups, two pendant aldehyde-derived carbonyl oxygens and two triflate oxygens. The complex is high spin between 300 and 20 K as indicated by variable field variable temperature magnetic measurements...
August 1, 2017: Inorganica Chimica Acta
Jessica K White, Russell H Schmehl, Claudia Turro
This article is a short review that presents a short review of photosubstitution reactions of Ru(II) imine complexes and illustrates their use in the development of therapeutic agents. The review begins with an overview of the photophysical behavior and common photoreactions of Ru(II) imine complexes, with select examples from the literature since the 1960s. It is followed by a more detailed picture of the application of knowledge gained over the years in the development of Ru(II) complexes for photobiology and photodynamic therapy...
January 1, 2017: Inorganica Chimica Acta
Yao-Rong Zheng, Kogularamanan Suntharalingam, Peter M Bruno, Wei Lin, Weixue Wang, Michael T Hemann, Stephen J Lippard
The cellular response evoked by a hexanuclear platinum complex, Pt6L4 (1), is reported. Compound 1, a 3-nm octahedral cage formed by self-assembly of six Pt(II) centers and four 2,4,6-tris(4-pyridyl)-1,3,5-triazine ligands (L), exhibits promising in vitro potency against a panel of human cancer cell lines. Unlike classical platinum-based anticancer agents, 1 interacts with DNA in a non-covalent, intercalative manner and promotes DNA condensation. In cancer cells, 1 induces DNA damage, upregulates p53, its phosphorylated form phospho-p53 and its downstream effector, p21, as well as both apoptosis and senescence...
October 1, 2016: Inorganica Chimica Acta
Kelsey M Boyle, Jacqueline K Barton
DNA has been exploited as a biological target of chemotherapeutics since the 1940s. Traditional chemotherapeutics, such as cisplatin and DNA-alkylating agents, rely primarily on increased uptake by rapidly proliferating cancer cells for therapeutic effects, but this strategy can result in off-target toxicity in healthy tissue. Recently, research interests have shifted towards targeted chemotherapeutics, in which a drug targets a specific biological signature of cancer, resulting in selective toxicity towards cancerous cells...
October 1, 2016: Inorganica Chimica Acta
Kevin Hwang, Parisa Hosseinzadeh, Yi Lu
This review summarizes research into the metal-binding properties of catalytic DNAzymes, towards the goal of understanding the structural properties leading to metal ion specificity. Progress made and insight gained from a range of biochemical and biophysical techniques are covered, and promising directions for future investigations are discussed.
October 1, 2016: Inorganica Chimica Acta
Timothy C Johnstone, Stephen J Lippard
Mixed amine/ammine motifs are important features in newer generation platinum anticancer agents, including the Pt(IV) prodrug satraplatin. One synthetic route that can be used to access platinum molecules with such structures exploits the trans effect during NH3-mediated cleavage of iodo-bridged platinum(II) dimers of the form [Pt(Am)I(μ-I)]2, where Am is an amine. A clear picture of the nature of these dimers that is consistent with the reactivity they exhibit has remained elusive. Moreover, technical aspects of this chemistry have impeded its more widespread use...
January 1, 2015: Inorganica Chimica Acta
Abhishek Dubey, Anurag Mishra, Jin Wook Min, Min Hyung Lee, Hyunuk Kim, Peter J Stang, Ki-Whan Chi
A suite of two new tetraruthenium metallarectangles 5 and 6 have been obtained from [2 + 2] self-assemblies between dipyridylethynyltriptycene 2 and one of the two dinuclear arene ruthenium clips, [Ru2 (μ-η (4)-OO∩OO) (η (6)-p-cymene)2][OTf]2 ; (OO∩OO = oxalate 3; 6,11-dihydroxy-5,12-naphthacenedionato (dotq) 4; OTf = triflate). These molecular rectangles are fully characterized by (1)H NMR spectroscopy, electrospray mass spectrometry. A single crystal of 6 was suitable for X-ray diffraction structural characterization...
November 1, 2014: Inorganica Chimica Acta
Johann Hlina, Rainer Zitz, Harald Wagner, Filippo Stella, Judith Baumgartner, Christoph Marschner
In order to evaluate the influence of germanium atoms in oligo- and polysilanes, a number of oligosilane compounds were prepared where two or more silicon atoms were replaced by germanium. While it can be expected that the structural features of thus altered molecules do not change much, the more interesting question is, whether this modification would have a profound influence on the electronic structure, in particular on the property of σ-bond electron delocalization. The UV-spectroscopic comparison of the oligosilanes with germanium enriched oligosilanes and also with oligogermanes showed a remarkable uniform picture...
October 1, 2014: Inorganica Chimica Acta
Hong Geun Lee, Phillip J Milner, Michael T Colvin, Loren Andreas, Stephen L Buchwald
The structure of the stable Pd(0) precatalyst [(1,5-cyclooctadiene)(L•Pd)2] (L = AdBrettPhos) for the Pd-catalyzed fluorination of aryl triflates has been further studied by solid state NMR and X-ray cystrallography of the analogous N-phenylmaleimide complex. The reactivity of this complex with CDCl3 to form a dearomatized complex is also presented. In addition, studies suggest that related bulky biaryl phosphine ligands form similar complexes, although the smaller ligand BrettPhos forms a monomeric [(1,5-cyclooctadiene)(L•Pd)] species instead...
October 1, 2014: Inorganica Chimica Acta
Courtney N Riddles, Mark Whited, Shalaka R Lotlikar, Korey Still, Marianna Patrauchan, Svitlana Silchenko, Nikolay Gerasimchuk
High-yield syntheses of N-piperidine-cyanacetamide (1), N-morpholyl-cyanacetamide (4) and their oxime derivatives N-piperidine-2-cyano-2-oximino-acetamide (HPiPCO, 2) and N-morpholyc-2-cyano-2-oximino-acetamide (HMCO, 5) were developed using two-step preparations. At first, the reactions of neat cyanoacetic acid esters and the respective cyclic secondary amines such as piperideine and morpholine afforded pure cyanacetamides, which were converted into cyanoximes at room temperature using the nitrosation reaction with gaseous CH3ONO...
March 1, 2014: Inorganica Chimica Acta
Samantha J Carrington, Indranil Chakraborty, Josh R Alvarado, Pradip K Mascharak
No abstract text is available yet for this article.
October 1, 2013: Inorganica Chimica Acta
Alexey N Gusev, Miki Hasegawa, Tomohito Shimizu, Tomonori Fukawa, Shoya Sakurai, Galyna A Nishchymenko, Victor F Shul'gin, Svetlana B Meshkova, Wolfgang Linert
Studies concerning synthesis, structure and luminescence of eight-coordinate Eu, Tb, Sm and Dy complexes of the type [Ln(acac)2(L)]Cl (Hacac = pentanedione-2,4 and L = bis(5-(pyridine-2-yl)-1,2,4-triazol-3-yl)propane) are reported in detail. The obtained complexes were investigated by various means including elemental- and thermogravimetric analysis, IR- and electron transition spectroscopy. The structure of the Tb complex was determined by single-crystal X-ray crystallography: Tb is eight-coordinate, and L acting only as a tetradentate chelate together with two bidentate acac ligands...
September 1, 2013: Inorganica Chimica Acta
Elisa Tordin, Manuela List, Uwe Monkowius, Siegfried Schindler, Günther Knör
Four new compounds of the general formula [M(L)(CH3COO)][PF6], where L is a tetradentate tripodal ligand such as tris[2-(dimethylamino)ethyl]amine (L1) or (2-aminoethyl)bis(2-pyridylmethyl)amine (L2) and M is Co(II), Ni(II) or Cu(II), have been prepared employing a simple two-step synthesis. The compounds have been characterised by elemental analysis, mass spectroscopy, IR spectroscopy and X-ray diffraction. The catalytic properties of the derivatives containing the aliphatic ligand L1 have been investigated in particular toward the oxidation of cyclohexane and adamantane in the presence of the sacrificial oxidant m-CPBA (meta-chloroperbenzoic acid)...
June 1, 2013: Inorganica Chimica Acta
Victor F Shul'gin, Oleg V Konnik, Susana V Abkhairova, Alexey N Gusev, Svetlana B Meshkova, Anna V Kiriyak, Eduard B Rusanov, Miki Hasegawa, Wolfgang Linert
A series of [H3O](+)[LnL4](-)·nH2O complexes (n = 1-3, Ln = Nd, (1), Sm (2), Eu (3), Tb (4); HL = 3-methyl-1-phenyl-4-formylpyrazole-5-one) were synthesized and characterized. The structures of the Sm(III) and Eu(III) complexes were investigated by X-ray diffraction. The isostructutal crystalls 2 and 3 consist the tetrakis [LnL4](-) anions which are linked by H-bonding with the hydroxonium counter-ion and water molecules. The lanthanide ion is situated in the center of distorted tetragonal antiprism formed by eight oxygen atoms of 4-formyl-5-hydroxypyrazolonate anions...
June 1, 2013: Inorganica Chimica Acta
Kevin M Williams, Amy D Poynter, Jonathan D Hendrie, Daniel C Jackson, Virginia K Martin
We have synthesized an oxaliplatin derivative using N,N'-dimethyl-1,2-diaminocyclohexane (Me2dach) as the diamine ligand. The complex (S,R,R,S)-Pt(Me2dach)(oxalate), where S,R,R,S represents the chiralities at N,C,C,N, respectively, was prepared and characterized by (1)H NMR spectroscopy, COSY, NOESY, and HMQC. Oxaliplatin reacts with N-acetylmethionine (N-AcMet) to form [Pt(dach)(N-AcMet-S)2] and [Pt(dach)(N-AcMet-S,N)], with the former favored at higher molar ratios of N-AcMet. In contrast, Pt(Me2dach)(oxalate) reacts to form [Pt(Me2dach)(N-AcMet-S,O)](+) even in the presence of excess N-AcMet...
May 24, 2013: Inorganica Chimica Acta
Nader Hassan, Julia Stelzl, Peter Weinberger, Gabor Molnar, Azzedine Bousseksou, Frank Kubel, Kurt Mereiter, Roman Boca, Wolfgang Linert
Two partly new [Fe(intz)6](BF4)2 complexes with n = 3 and 4 (i3tz = 1-isopropyl-1H-tetrazole, i4tz = 1-isobutyl-1H-tetrazole) were synthesized and characterised by X-ray powder diffraction, magnetic susceptibility measurements, vibrational, electronic and 57Fe-Mößbauer spectroscopy as well as DSC. The [Fe(i3tz)6](BF4)2 complex was re-investigated and shows an incomplete spin transition at Tc ∼ 109 K, while the [Fe(i4tz)6](BF4)2 features a complete but rather gradual spin transition with T½ = 223 K...
February 24, 2013: Inorganica Chimica Acta
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