journal
https://read.qxmd.com/read/38225777/anti-inflammatory-effect-of-high-flux-dialyzer-surface-area-2-6m2-in-high-flux-hemodialysis-and-hemodiafiltration
#1
JOURNAL ARTICLE
Hesham ElSayed, Aya Mohamed, Hayam M Aref, Hussein S Hussein, Khaled Gouda
Dialysis therapy has remarkably evolved through the innovation in dialyzers and hemodialysis modalities, enhancing patients' quality of life. The efficacy of dialysis can be determined by measuring the reduction ratio (RR) of middle molecules such as Interleukin-6 (IL-6) and Procalcitonin. In our study, we tested a high-flux dialyzer, BIOPURE (Biorema) 260 HF, with a surface area (SA) of 2.6 m2, in terms of IL-6 and Procalcitonin removal while performing high-flux hemodialysis (HF-HD) and post-dilution online hemodiafiltration (OL-HDF)...
January 2024: Egyptian Journal of Immunology
https://read.qxmd.com/read/38225776/evaluation-of-interleukin-17-a-levels-in-patients-with-breast-carcinoma
#2
JOURNAL ARTICLE
Heba M El-Batal, Mahmoud M Kamel, Inas Moaz, Noha M Gohar
Breast cancer is a highly common form of cancer that impacts a considerable proportion of women on a global scale. Interleukin 17A (IL-17A) is a cytokine that has both anti-tumor and pro-tumor effects, which can vary depending on the specific tumor microenvironment. The aim of this study was to determine whether IL-17A can be used as a biomarker for diagnosis of breast cancer. Therefore, we compared concentrations of serum IL-17A in patients suffering from breast carcinoma and normal control women by an enzyme-linked immunosorbent assay (ELISA)...
January 2024: Egyptian Journal of Immunology
https://read.qxmd.com/read/38225775/impact-of-serum-il-10-on-prediction-of-early-allograft-rejection-in-liver-transplantation
#3
JOURNAL ARTICLE
Mai A El-Deeb, Ashraf Okba, Mahmoud El-Meteini, Eman E Ahmed, Rasha S Mohamed, Rasha Mamdouh, Mariam Maged
Tissue transplantation is the preferred treatment for end organ failure such as heart, lung, kidney, and liver. The immune system recognizes the transplant as non self if the donor and recipient are not genetically identical. Multiple cytokines are involved in this process; however, little is known about their predictive role in rejection. Interleukin 10 (IL-10) which exhibits anti-inflammatory activity could be used as early predictor of acute rejection. The current study intended to determine any potential relationship between acute allograft rejection and blood IL-10 levels in liver transplant (LT) recipients...
January 2024: Egyptian Journal of Immunology
https://read.qxmd.com/read/38225774/study-of-cd4-t-lymphocytes-in-chronic-kidney-disease-patients-with-covid-19-infection
#4
JOURNAL ARTICLE
Shereen P Aziz, Amany Abbas, Sherif A Sayed, Tamer Mohamed, Osama Mohy, Ahmed Sedky
Chronic kidney disease (CKD) is a functional and/or structural kidney damage that lasts more than three months duration. This study aimed to analyze CD4+ T-lymphocytes levels in chronic CKD patients specifically, during the coronavirus disease 2019 (COVID-19) pandemic to assess the adaptive cell-mediated immunity. The study measured absolute CD4+ T-lymphocytes counts by flowcytometry among participating individuals. The study included 146 subjects, 40 CKD patients and tested positive for COVID-19, 44 CKD patients and tested negative for COVID-19 and 62 normal individuals as controls...
January 2024: Egyptian Journal of Immunology
https://read.qxmd.com/read/38224471/urinary-tissue-factor-utf-tissue-factor-pathway-inhibitor-tfpi-and-plasmin-as-novel-biomarkers-in-early-diagnosis-of-lupus-nephritis
#5
JOURNAL ARTICLE
Mohammed H Mustafa, Effat A E Tony, Salwa S Elgendi, Alaa S Abdelkader, Ayat A Salah, Rasha A Madkour
Systemic lupus erythematosus (SLE) is an autoimmune inflammatory disease, with multi systematic affection. Lupus nephritis (LN) is the most frequent cause of renal damage in SLE patients with variable presentations that may progress to end stage renal failure. Coagulation disorders are frequently reported in SLE and LN with higher mortality rates. Renal biopsy is an invasive process, and the existing indicators for LN diagnosis and activity are unreliable. New urinary biomarkers with significant validity, safety, and accuracy are the current focus of most studies...
January 2024: Egyptian Journal of Immunology
https://read.qxmd.com/read/38224470/serum-selenium-status-in-egyptians-patients-who-had-graves-disease-with-and-without-ophthalmopathy
#6
JOURNAL ARTICLE
Ghada A Hasanin, Magda S Mohamed, Maram M Maher, Azza M Ahmed, Hanan M ALi, Hany K Mansour
Selenium is efficient in reducing the progression of active Graves' orbitopathy and improving life quality. The impact of mending relative deficiency of selenium on improving Graves' orbitopathy is not known, due to the lack of previous measurement of baseline levels of selenium. The study object was to determine whether serum selenium levels are lower in patients with Graves' ophthalmopathy (GO) disease in comparison with those without ophthalmopathy. This prospective case control study was conducted between 2019 and 2021 at the endocrine and ophthalmology clinics, Ain Shams University, Cairo...
January 2024: Egyptian Journal of Immunology
https://read.qxmd.com/read/38224469/the-role-of-urinary-kidney-injury-molecule-1-kim-1-in-monitoring-the-treatment-response-in-egyptian-lupus-nephritis-patients
#7
JOURNAL ARTICLE
Lamis Khedr, Howayda El-Shinnawy, Hayam Hebah, Hossam Rashwan, Reem M Elsharabasy
Lupus nephritis (LN) affects almost two-thirds of systemic lupus erythematosus (SLE) patients. Despite initial aggressive therapy, up to 25% of patients with LN will progress to permanent renal damage. Conventional serum markers for LN lack the sensitivity of an ideal biomarker. Urinary kidney injury molecule-1 (UKIM-1) is an excellent biomarker for early diagnosis of acute kidney injury and predicting renal outcomes. This study intended to determine the predictive performance of UKIM-1 among LN patients in response to induction therapy by assessing and correlating its levels with renal disease activity...
January 2024: Egyptian Journal of Immunology
https://read.qxmd.com/read/38224276/the-role-of-urinary-biomarker-monocyte-chemoattractant-protein-mcp-1-in-correlation-with-different-histopathological-classes-of-lupus-nephritis-in-egyptian-patients
#8
JOURNAL ARTICLE
Howayda El-Shinnawy, Osama Mahmoud, Waleed Abdelmohsen, Amr Ahmed, Lamis Khedr
Lupus nephritis (LN) affects almost two-thirds of systemic lupus erythematosus (SLE) patients. Renal biopsy is the gold standard for the diagnosis of LN. However, repeated biopsies are not always performed in clinical practice, and they carry some risk. Therefore, minimally invasive techniques, as urinary biomarkers, are promising tools for the diagnosis and monitoring of SLE. Previous studies evaluated urinary monocyte chemoattractant protein-1 (MCP-1) in patients with SLE, reported higher levels of urinary MCP-1 in patients with active LN than non-active LN...
January 2024: Egyptian Journal of Immunology
https://read.qxmd.com/read/38224275/assessment-of-long-noncoding-rna-ccat1-using-real-time-polymerase-chain-reaction-in-colorectal-cancer-patients
#9
JOURNAL ARTICLE
Amal A Mahmoud, Hanan O Mohamed, Mahmoud R Shehata, Alyaa A S Refae, Mostafa H Abd El Salam, Mohamed I Seddik
Colorectal cancer (CRC) is linked to high mortality, mainly when discovered in its advanced stages. Several studies have pointed to the role of epigenetic factors in CRC and other cancers. Long non-coding RNAs (lncRNAs) are involved in the initiation, progression, metastasis, and modulation of the response to chemotherapeutic modalities of CRC as vital contributors to epigenetic mechanisms. Colon cancer-associated transcript-1 (CCAT1) is one of the lncRNAs that have been dysregulated in serum samples, providing a non-invasive route for diagnosing CRC patients...
January 2024: Egyptian Journal of Immunology
https://read.qxmd.com/read/38224274/insight-on-the-hepatitis-b-virus-and-host-immune-mechanisms-in-the-context-of-occult-hepatitis
#10
JOURNAL ARTICLE
Manal El Said, Asim M Alshanberi, Faten Abouelmagd, Mohammed Shaikhomer, Fatma E Hassan
Hepatitis B virus infection is the 10th leading cause of death around the world. Occult HBV infection (OBI) represents those with a viral load of < 104 IU/ml. Among permanent blood recipients, OBI appears to be the most common cause of posttransfusion hepatitis. Moreover, OBI may reduce hepatitis C virus (HCV) treatment responsiveness in people with chronic HCV infection, and OBI may become acutely reactivated when on immunosuppression or potentially contribute to chronic liver disease. Since most previous studies used either small sample sizes, diverse populations, or were cross-sectional in design, it is possible that using multiple techniques with varying sensitivity for HBV DNA measurement in the liver or serum will shed light on discrepancies in the impact of OBI in cases with chronic liver disease...
January 2024: Egyptian Journal of Immunology
https://read.qxmd.com/read/38224227/evaluation-of-klotho-expression-on-peripheral-blood-lymphocytes-among-hemodialysis-patients-and-its-possible-contribution-to-their-immuno-compromised-status
#11
JOURNAL ARTICLE
Riham Elmahalawy, Mohamed N Farres, Nashwa El-Khazragy, Marwa S Abdel-Samea, Hossam M Elkady
Infection is the second most common cause of mortality among end-stage kidney disease (ESKD) patients. Uremic toxins are the main cause of impaired immune response among ESKD patients. Klotho gene, the anti-aging gene, encodes the transmembrane alpha klotho (αKL) protein which acts as an obligate coreceptor for fibroblast growth factor 23 (FGF23). Klotho protein may play a role in immune cell functions, particularly in anti-inflammatory response; however, its role is still incompletely understood. In the present study, we aimed to measure αKL protein expression on peripheral blood lymphocytes (PBLs) among hemodialysis (HD) patients, and we assumed that decreased αKL expression on PBLs may contribute to the impaired immunity among HD patients...
January 2024: Egyptian Journal of Immunology
https://read.qxmd.com/read/38224226/significance-of-inflammatory-markers-in-primary-fibromyalgia-syndrome-and-their-relation-in-assessing-the-disease-severity
#12
JOURNAL ARTICLE
Esraa A El-Sawy, Mervat M Abdul Hakim, Abeer El-Zohiery, Sherihan M Salama
Fibromyalgia syndrome (FMS) is a musculoskeletal disorder characterized by diffuse chronic musculoskeletal pain associated with various other symptoms. Although the etiology and pathogenesis of FMS are still unclear, it was reported to have a possible inflammatory basis. No laboratory marker is currently available to diagnose the disease. This study aimed to search for biomarkers useful in diagnosis of FMS. We assessed blood erythrocyte sedimentation rate (ESR), neutrophil lymphocyte ratio (NLR), the mean platelet volume (MPV) and platelet distribution width (PDW), and serum levels of C-reactive protein (CRP), as inflammatory markers in primary FMS patients and their relationship with disease severity and depression scores...
January 2024: Egyptian Journal of Immunology
https://read.qxmd.com/read/38224225/autoantibodies-profile-in-autoimmune-liver-diseases-and-chronic-viral-hepatitis
#13
JOURNAL ARTICLE
Rehab A Rabie, Alaa Hadhoud, Shymaa Abdelazim, Mohamed I Radwan, Marwa H Attia, Mohammed A Hasuna
Despite their low prevalence, autoimmune liver diseases (AILD) cause liver cirrhosis, progress and leads to mortality from liver failure. Autoantibodies are confirmed to have significance in the early screening of AILD patients, especially in those who are asymptomatic before onset of clinical signs. This study aimed to assess levels of liver autoantibodies and their association with clinical manifestations of autoimmune liver diseases and chronic viral hepatitis (CVH) patients. This case-control study included 50 patients (case group of 25 patients with AILD and control group of 25 patients with CVH)...
January 2024: Egyptian Journal of Immunology
https://read.qxmd.com/read/38224035/interleukin-8-genetic-polymorphism-and-its-relation-to-helicobacter-pylori-infection-and-helicobacter-pylori-associated-gastric-diseases
#14
JOURNAL ARTICLE
Ibrahim A Amin, Mona A Hassan, Sherein G Elgendy, Ahmed S Abdelmohsen, Mamdouh Y Ali, Bahaa-Eldin A Abdel-Raady
Helicobacter pylori (H. pylori) infection has a variety of clinical outcomes, and host genetic factors play an important role in this process. Cytokines are important factors in mediating and controlling the inflammatory process during H. pylori infection. Interleukin-8 (IL-8) plays a critical role in the epithelial cell response to H. pylori infection and the development of H. pylori-related gastric disorders. The IL-8 gene has an A/T base pair polymorphism in the promoter region (-251), which has been linked to an increase in interleukin production by gastric epithelial cells...
January 2024: Egyptian Journal of Immunology
https://read.qxmd.com/read/38224034/serum-microrna-146b-expression-for-malignancy-prediction-in-euthyroid-patients-with-indeterminate-thyroid-nodules
#15
JOURNAL ARTICLE
Amal O Abdelfadeil, Mohamed R Halawa, Iman Zaky, Merhan Samy, Lamyaa Salem, Ahmed M Bahaaeldin
Thyroid nodules are frequently found, but the vast majority of them are benign. The difficulty in managing thyroid nodules is correctly diagnosing the minority of those who have malignancy. Thyroid fine-needle aspiration cytology (FNAC) with indeterminate cytology continues to raise doubts about the presence of thyroid cancer, leading to an unnecessary thyroidectomy. Circulating miRNAs may be useful as diagnostic and prognostic markers for a variety of cancers, including thyroid cancer. The goal of the present study was to determine the predictive value of serum miRNA-146b expression level for thyroid cancer by estimating its level in a group of euthyroid patients with thyroid nodules with indeterminate FNAC results...
January 2024: Egyptian Journal of Immunology
https://read.qxmd.com/read/38224033/prevalence-of-viral-hepatitis-a-b-c-and-e-infection-and-co-infection-among-hospitalized-children-in-cairo-egypt
#16
JOURNAL ARTICLE
Enas Mostafa, Reem El-Shenawy, Ashraf Tabll, Sahar Shoman
Viral hepatitis is considered a public health issue facing the entire world. The World Health Organization encouraged all countries to work together to eliminate this fatal infection and achieve the 2030 agenda. The present study aimed to investigate the silent infection of viral hepatitis (A, B, C, and E) among hospitalized children in Cairo, Egypt, to control and avoid chronic infection early on. This cross-sectional study included 184 randomly selected hospitalized children from three different hospitals in Cairo, Egypt...
January 2024: Egyptian Journal of Immunology
https://read.qxmd.com/read/38224032/assessment-of-tenascin-c-levels-in-the-serum-of-patients-with-bronchial-asthma
#17
JOURNAL ARTICLE
Aya Elgendy, Mohamed El-Shayeb, Yasmine A Hassanein, Hossam M Elkady
Asthma is a heterogeneous disease that affects a large proportion of the global population and is distinguished by airway hyperresponsiveness to direct and indirect stimulations. It is a multifactorial disease that is triggered by heredity and environmental causes. Tenascin C (TNC) is an extracellular matrix glycoprotein that promotes inflammatory cell migration from the interstitium to the airways. Stimulation of TNC is through cytokines from T helper 2 (Th2) cells, in addition, it proliferates within basement membranes of the airways in asthmatic patients...
January 2024: Egyptian Journal of Immunology
https://read.qxmd.com/read/38224031/serum-microrna-223-as-a-potential-biomarker-for-allergic-rhinitis-and-its-correlation-to-eosinophil-derived-neurotoxin
#18
JOURNAL ARTICLE
Fedaa Nabil, Mohamed A Alnemr, Sara F Saadawy, Haytham K A Mahrous, Yasmin A Fahmy
Allergic rhinitis (AR) is a global health problem. It is an inflammatory condition defined by a malfunction of the immune system's regulatory mechanism. MicroRNA-223 (miRNA-223) has been linked to the modulation of AR in the last few years. The goal of this study was to determine whether miR-223 can be utilized as a potential biomarker for diagnosis of AR, and whether it correlates with the total nasal symptom score (TNSS) along with serum interleukin-17 (IL-17), interleukin-4 levels (IL-4) and eosinophil-derived neurotoxin (EDN)...
January 2024: Egyptian Journal of Immunology
https://read.qxmd.com/read/38224030/evaluation-of-a-multiplex-polymerase-chain-reaction-for-the-diagnosis-of-infectious-diarrhea-in-intensive-care-unit-patients-in-upper-egypt
#19
JOURNAL ARTICLE
Asmaa O Ahmed, Asmaa M Abdelaziz, Hebat-Allah G Rashed, Mohammed Tolba, Amal A Mahmoud
The rapid diagnosis of infectious diarrhea is lifesaving for intensive care unit (ICU) patients. This study evaluated a commercially available multiplex polymerase chain reaction (PCR) (BioFire FilmArray) for the diagnosis of parasitic and bacterial infections in ICU patients with secretory diarrhea in comparison to other traditional methods. This cross-sectional study included 50 subjects with infectious diarrhea. Their stool samples were subjected to macroscopic and microscopic examinations, concentration techniques, permanent staining techniques, stool culture, identification of bacterial infection by the Vitek 2 Compact 15 System, and molecular diagnosis of bacterial or parasitic infections by BioFire FilmArray multiplex PCR...
January 2024: Egyptian Journal of Immunology
https://read.qxmd.com/read/37801033/in-vitro-evaluation-of-the-potential-immunosuppressive-effect-of-panobinostat-on-cultured-lymphocytes-retrieved-from-childhood-systemic-lupus-erythematosus-patients
#20
JOURNAL ARTICLE
Neimat A Yassin, Maha Abdelsalam, Amr M El-Sabbagh, Amira I Morsy, Amira A Haleem, Ibrahim El-Shenbaby, Gehan A El Wakeel, Ayman Hammad, Nashwa Hamdy, Dena M Abd-El Ghafaar, Eman B Elmarghany, Mai S Korkor, Riham Eid
Although many drugs are available for childhood systemic lupus erythematosus (SLE) treatment, the adverse effects and poor response in some cases make it crucial to find new drugs targeting various pathways in disease pathogenesis to improve overall outcomes. This study aimed to (i) investigate the effect of Panobinostat on cultured lymphocytes obtained from children with active SLE and (ii) to compare that effect with standard drugs used in SLE, such as Prednisone and hydroxychloroquine. The study included 24 SLE active patients, divided into four equal groups...
October 2023: Egyptian Journal of Immunology
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