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Egyptian Journal of Immunology

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https://www.readbyqxmd.com/read/29708315/glypican-3-and-melanoma-antigen-genes-1-and-3-as-tumor-markers-for-hepatocellular-carcinoma
#1
Nadia M El-Wahab, Hebat-Allah G Rashed, Wafaa T El-Sherif, Sohair K Sayed, Mohamed O Abd-Elmalek, Abeer Refaiy, Hussein Fakhry, Abeer A Mokhtar
Hepatocellular carcinoma (HCC) is the commonest liver cancer; its incidence and prevalence are continuously increased. Glypican3 (GPC3), melanoma antigen-1, 3 genes (MAGE1 and 3) are tumor markers used in HCC. We evaluated their role in HCC detection and assessed their relation to tumor parameters. Three groups, HCC group, liver cirrhosis group and a control group were studied. AFP, GPC3, and MAGE1 and 3 mRNA were determined in all study subjects. Tissue GPC3 was examined in patients with HCC only. Serum AFP and GPC3 were elevated in HCC group compared to other groups (P < 0...
June 2017: Egyptian Journal of Immunology
https://www.readbyqxmd.com/read/29528590/toll-like-receptor-3-polymorphisms-in-hepatitis-b-virus-infection
#2
Azza M EzzEl-Din, Sherif H Galal, Asmaa O Ahmed, Sherif I Kamel, Dalia T Kamal
Hepatitis B virus (HBV) is the one of the major causes of chronic liver disease. Individuals exposed to HBV show wide spectrum outcomes including immunized persons, asymptomatic carrier, chronic active hepatitis, cirrhosis and HCC. The outcome of HBV infection and the severity of associated liver diseases are determined by the nature and strength of host immune responses against the virus. There is accumulating evidence that the innate branch of the host immune system plays an important role in the control of HBV infection...
June 2017: Egyptian Journal of Immunology
https://www.readbyqxmd.com/read/29528589/the-effect-of-autologous-serum-therapy-in-chronic-spontaneous-urticaria-depends-on-autologous-serum-skin-test-positivity
#3
Sahar Z Elazab, Waheed F Hessam
Chronic spontaneous urticaria (CSU) is a common distressing disease caused mainly by autoreactive mechanisms. Autologous serum therapy (AST) has been tried for treatment of many autoimmune diseases including chronic urticaria. We assessed the effect of AST in autologous serum skin test (ASST)-positive and ASST-negative CSU patients. The study included 40 patients clinically diagnosed as CSU. Twenty ASST-positive patients and 20 ASST-negative patients received AST for 8 weeks. Urticarial activity was assessed at baseline, 4th week, 9th week, and at the 12th week by the weekly urticarial activity score (UAS-7) according to the EAACI/GA2LEN/EDF/WAO guidelines...
June 2017: Egyptian Journal of Immunology
https://www.readbyqxmd.com/read/29528588/vitamin-d-receptor-fok1-bsm-1-gene-polymorphisms-in-systemic-lupus-erythematosus-and-osteoarthritis-autoimmune-inflammatory-versus-degenerative-model
#4
Mona S Ghaly, Dahlia I Badra, Omar Dessouki, Nermine N Elmaraghy, Ranya Hassan
Vitamin D deficiency has been described in SLE and OA. Low vitamin D level is prevalent in Egyptian SLE patients while controversial studies are present regarding its level in OA patients in Egypt. We investigated whether vitamin D receptor (VDR) genes Bsm1 and Fok1 polymorphisms could be used as genetic markers for the susceptibility to SLE and /or OA in a sample of Egyptian population. The study was carried out on 100 SLE patients, 100 osteoarthritic patients and 100 normal controls using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP)...
June 2017: Egyptian Journal of Immunology
https://www.readbyqxmd.com/read/29528587/cd81-and-cd19-as-marker-of-activity-in-systemic-lupus-erythematosus-disease
#5
Zakia Abu-Zahab, Niveen M Gad, Seham Sabry, Sherif A Nassib
Systemic Lupus Erythematosus is systematic auto-immune disease characterized by abnormal activation of B cell with production of autoantibodies. Due to its heterogeneous course, there is a need for new markers to help in diagnosing and monitoring disease activity. The aim of this study was to identify the immunopathological role of CD19 and CD81 expression in patients with SLE and their correlation with the disease activity. Peripheral blood (PB) was collected from 40 SLE patients (20 active and 20 inactive) and 20 controls...
June 2017: Egyptian Journal of Immunology
https://www.readbyqxmd.com/read/29528586/validity-of-specific-immunoglobulin-e-assay-in-tear-film-for-detection-of-allergens-inducing-different-types-of-allergic-conjunctivitis
#6
Randa S Abdel-Latif, Nissreen E ELBadawy, Basem M Ibrahim
This is a prospective interventional comparative study which aimed to investigate correlation between tear film allergen specific IgE levels and the skin prick test in diagnosing different types of allergic conjunctivitis. One hundred twenty patients with allergic conjunctivitis were included in this study and were classified into 4 groups based on the type of allergic conjunctivitis. Patients were subjected to skin prick test (SPT). Micro capillary method was used to collect tear samples for the quantitative assessment of specific IgE by Immune blot assay...
June 2017: Egyptian Journal of Immunology
https://www.readbyqxmd.com/read/29528585/food-specific-ige-as-a-biomarker-of-oral-immunotherapy-efficacy-in-comparison-to-double-blind-food-challenge-test
#7
Nissreen E ELBadawy, Randa S Abdel-Latif
Specific immunotherapy (SIT) is one of the important lines for the treatment of food allergy. Efficacy tests for clinical response to SIT are limited and subjective. In this study, we aimed to evaluate the validity of food specific Ig E levels as a biomarker of clinical improvement in children with food allergy treated with oral immunotherapy (OIT). We analysed 184 children with food allergy, 143 had undergone 2 years of food OIT and 41 were on allergen restricted diet and considered as control. All patients were subjected to Double-Blind Placebo-Controlled Food Challenge test (DBPCFC), allergic symptom score calculation, and serum food specific Ig E level before and after oral immunotherapy for treated patients and after 2 year of allergen restricted diet for the control group...
June 2017: Egyptian Journal of Immunology
https://www.readbyqxmd.com/read/29528584/effect-of-allergen-specific-immunotherapy-on-serum-levels-of-il-17-and-il-35-in-allergic-rhinitis-patients
#8
Sahar Z Elazab, Waheed F Hessam
Allergic rhinitis (AR) is mediated by many proinflammatory and anti-inflammatory cytokines as interleuhin-17 (IL-17) and interleukin-35 (IL-35) respectively. We assessed the effect of allergen specific immunotherapy (IT) on the serum levels of IL-17 and IL-35 in patients with AR sensitive to house dust mites (HDMs). Twenty patients with AR sensitive to HDMs and ten healthy control subjects were included in the study. Sensitivity to HDMs was diagnosed by positive skin prick test. Patients were treated by cluster IT...
June 2017: Egyptian Journal of Immunology
https://www.readbyqxmd.com/read/29528583/circulating-fibroblast-growth-factors-21-and-23-as-biomarkers-of-progression-in-diabetic-nephropathy-in-type-2-diabetes-with-normoalbuminuria
#9
Amany M El-Saeed, Ghada F El-Mohasseb
Diabetic nephropathy (DN) is a progressive kidney disease. Previous studies reported that microalbuminuria might not be a sufficient marker to identify diabetic patients at risk of kidney disease progression. Fibroblast growth factors 21 (FGF21) and 23 (FGF23) may play an important role in the DN development and progression. We aimed to assess levels of FGF21 and FGF23 in patients with type 2 diabetes (T2D) with normoalbuminurea, to determine their association with other biochemical parameters and to verify their role as contributing factors to development of DN...
June 2017: Egyptian Journal of Immunology
https://www.readbyqxmd.com/read/29528582/interleukin-22-and-chemokine-interferon-%C3%AE-inducible-10-ip-10-levels-in-chronic-hepatitis-c-patients-and-treatment-response-to-pegylated-interferon-and-ribavirin-therapy
#10
Ghaly M F, Fadia M Attia, Rania M Saleh, Heba M, Maha Anani
IL-22 plays a vital role in improving hepatic damage by targeting hepatocytes that express high levels of IL-22 receptor1. IP-10 is a chemokine that recruit mononuclear cells to liver parenchyma and improves the host immune response against hepatitis C virus. The study targeted 27 patients with chronic HCV who received pegylated Interferon and Ribavirin. IL-22 and IP-10 serum levels were measured by Elisa. The level of the serum IL-22 is higher in HCV patients groups receiving the antiviral treatment compared to control group and its levels significantly increased with response to treatment...
June 2017: Egyptian Journal of Immunology
https://www.readbyqxmd.com/read/29528581/microrna-26a-expression-in-peripheral-blood-mononuclear-cells-and-correlation-with-serum-interleukin-17-in-relapsing-remitting-multiple-sclerosis-patients
#11
Fatma M Mahmoud, Nadia M ElSheshtawy, Wafaa K Zaki, Dina M Zamzam, Nehal M Fahim
Multiple sclerosis (MS) is a chronic multifocal inflammatory demyelinating disease. One of the main cells that play a crucial role in pathogenesis of MS is T helper 17 (Th 17). There are growing interests in nominating microRNAs in Th17 cell differentiation and suggesting new therapeutic modalities. The aim of the study was to assess microRNA 26a (miR26a) expression in peripheral blood mononuclear cells of relapsing - remitting MS patients as compared to healthy control subjects and examine association of these levels with serum IL17...
June 2017: Egyptian Journal of Immunology
https://www.readbyqxmd.com/read/29528580/association-of-ctla-4-49-a-g-and-ct60-gene-polymorphism-with-graves-disease
#12
Nehad A Fouad, Aml M Saeed, Ahmed W Mahedy
Graves' disease (GD) is an organ specific autoimmune disease of thyroid gland with genetic and environmental causes. One of genetic factors that have been implicated in the development of this disease is CTLA-4 gene polymorphism. This study aimed to investigate the association of CTLA-4 polymorphisms at position +49A/G, and CT60 with susceptibility to Graves' disease in Saudi patients. 40 adult Saudi patients with GD and 30 healthy controls were genotyped for the +49 A/G and CT60 of the CTLA4 gene using restriction fragment length polymorphism analysis (RFLP)...
June 2017: Egyptian Journal of Immunology
https://www.readbyqxmd.com/read/29528579/relevance-of-25-oh-vitamin-d-deficiency-on-hashimoto-s-thyroiditis
#13
Hoda G Bakr, Takwa E Meawed
An association between low levels of vitamin D and Hashimoto's thyroiditis was suggested. This study aimed to determine the status of 25 (OH) vitamin D in Hashimoto's thyroiditis. A case-control study was designed, a Hashimoto's thyroiditis patient group (n=30) and two control groups including Graves' disease (30) and a healthy control group (20). TSH, Free T3, Free T4, antithyroid antibodies (antithyroglobulin and antithyroid peroxidase), calcium and serum 25 (OH) vitamin D were assessed. Vitamin D and calcium levels were significantly lower in Hashimoto thyroiditis and Graves' disease versus healthy controls...
June 2017: Egyptian Journal of Immunology
https://www.readbyqxmd.com/read/29528578/adsorption-technique-in-pre-transfusion-testing-for-patients-with-warm-type-autoimmune-hemolytic-anemia
#14
Dalia M El Dewi, Tarek Metwally
Warm auto-antibodies are directed against patients' own red blood cell antigens and can interfere with and complicate investigations for the detection and identification of RBC allo-antibodies. Most patients with autoimmune hemolytic anemia (AIHA) have already been transfused and the patients' phenotype can be difficult to determine. In warm type AIHA; the auto- antibodies in the patient's serum react with all normal red blood cells and make it impossible to find compatible blood. Special appropriate compatibility test procedures in a reference laboratory allow the detection and identification of clinically significant allo- Abs that may be masked by the auto- Abs...
June 2017: Egyptian Journal of Immunology
https://www.readbyqxmd.com/read/29528577/serum-microrna-122-and-microrna-155-markers-of-disease-progression-in-hepatitis-c-viral-infection
#15
Abeer Sheneef, Asmaa M Gouda, Asmaa N Mohammad, Laila M Yousef, Amal K Noureldin
Chronic HCV with its longstanding complications of cirrhosis and HCC is a highly prevalent and challenging problem in Egypt. Recently, microRNAs are ranked as potential biomarkers for early diagnosis of HCV related complications. The aim of the present study was to evaluate the role of miRNA-122 and miRNA-155 for prediction of progression of HCV infection and for diagnosis of HCC. A total of 92 chronic HCV patients [chronic HCV (group 1, n =32); chronic HCV with cirrhosis (group 2, n=31); chronic HCV with HCC (group 3, n=29)] were enrolled into the study...
June 2017: Egyptian Journal of Immunology
https://www.readbyqxmd.com/read/29528576/the-role-of-bcl-2-and-bax-as-markers-of-disease-progression-in-hepatitis-c-virus-infected-patients
#16
Ahmed Sadek, Abeer Sheneef, Eman A Sabet, Laila M Yousef, Amal H Ali, Amal K Nor-El-Din, Ahmed M Mahmoud
Many apoptotic markers have been linked to hepatic cell injury in HCV-related liver diseases, and hence could be used as potential markers for early detection of the disease. The present study aimed to assess the role of apoptotic markers Bcl-2 and Bax in the pathogenesis of chronic HCV-related liver diseases. A total of 85 participants were enrolled into the study; 70 chronic HCV patients (35 non-cirrhotic and 35 cirrhotic), and 15 healthy controls. The serum levels of Bcl-2 and Bax were assayed in all participants by ELISA...
June 2017: Egyptian Journal of Immunology
https://www.readbyqxmd.com/read/29528575/serum-thymus-and-activation-regulated-chemokine-tarc-il-18-and-il-18-gene-polymorphism-as-associative-factors-with-atopic-dermatitis
#17
Maha K Gohar, Amal H Atta, Mohamed M Nasr, Doaa N Hussein
Atopic dermatitis (AD) is a worldwide chronic inflammation of skin.Many factors and chemokines play role in pathogenesis of AD. Identifying the reliable biomarkers to diagnose and assess severity of AD is important. In this study we aimed to find a reliable biomarker to determine the severity of AD and monitor treatment as well as, examining the possible association between IL-18 gene [rs 187238] promoter polymorphism and AD disease. The study included 30 Egyptian patients with AD and 30 healthy controls. Patients were clinically evaluated according to SCORAD scoring system...
June 2017: Egyptian Journal of Immunology
https://www.readbyqxmd.com/read/29528574/prevalence-of-vitamin-d-deficiency-in-adult-patients-with-systemic-lupus-erythematosus-in-kingdom-of-bahrain
#18
Eman Farid, Ahmed A Jaradat, Ola Al-Segai, Adla B Hassan
Vitamin D deficiency (VDD) has been implicated as an important factor in the development or aggravation of systemic lupus erythematous (SLE). Patients with SLE are especially prone to the development of VDD due to the nature of their illness and avoidance of sun exposure. The prevalence of VD status in Bahraini patients with SLE has not been studied. Our aim is to study the prevalence of VDD in Bahraini cohort with SLE. Fifty-eight Bahraini patients with SLE were included retrospectively in this study. Most of the patients were females 50/58...
June 2017: Egyptian Journal of Immunology
https://www.readbyqxmd.com/read/29120588/association-between-serpinb2-gene-expression-by-real-time-pcr-in-respiratory-epithelial-cells-and-atopic-bronchial-asthma-severity
#19
Nissreen E ELBadawy, Randa S Abdel-Latif, Hoda A El-Hady
Atopic bronchial asthma is chronic respiratory diseases of high frequency and high morbidity and mortality especially in patients refractory to the ordinary medical management. This study aimed to investigate the association between Serpin family B Member 2 (SERPINB2) gene expression and bronchial asthma severity. A total of 127 adult patients with asthma were enrolled in this study. Allergic respiratory symptoms were assessed and patients were classified according to Global Initiative for Asthma (GINA) criteria...
January 2017: Egyptian Journal of Immunology
https://www.readbyqxmd.com/read/29120587/matrix-metalloproteinase-2-and-osteoprotegrin-as-new-markers-of-increased-atherosclerotic-risk-in-egyptian-patients-with-chronic-kidney-disease
#20
Amany M Elsaeed, Amal H Ibrahiem, Asmaa A Ali
The prevalence of chronic kidney disease (CKD) is rising continuously. Cardiovascular disease (CVD) is among the leading causes of death and premature mortality of patients with CKD. It has been suggested that the assessment of CKD-associated CVD risk factors together with conventional risk factors should be performed in order to improve the prediction of coronary heart disease risk. The reduction of these factors seems to be effective in lowering cardiovascular (CV) morbidity and mortality in patients with CKD...
January 2017: Egyptian Journal of Immunology
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