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International Journal of Neuropsychopharmacology

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https://www.readbyqxmd.com/read/29788422/n-acetyl-and-glutamatergic-neurometabolites-in-perisylvian-brain-regions-of-methamphetamine-users
#1
Jinsong Tang, Joseph O'Neill, Jeffry R Alger, Zhiwei Shen, Maritza C Johnson, Edythe D London
Background: Methamphetamine induces neuronal N-acetyl-aspartate synthesis in preclinical studies. In a preliminary human proton magnetic resonance spectroscopic imaging investigation, we also observed that N-acetyl-aspartate+N-acetyl-aspartyl-glutamate in right inferior frontal cortex correlated with years of heavy methamphetamine abuse. In the same brain region, glutamate+glutamine is lower in methamphetamine users than in controls and is negatively correlated with depression. N-acetyl and glutamatergic neurochemistries therefore merit further investigation in methamphetamine abuse and the associated mood symptoms...
May 21, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29788232/chronic-stress-exposure-reduces-parvalbumin-expression-in-the-rat-hippocampus-through-an-imbalance-of-redox-mechanisms-restorative-effect-of-the-antipsychotic-lurasidone
#2
Andrea C Rossetti, Maria Serena Paladini, Martina Colombo, Piotr Gruca, Magdalena Lason-Tyburkiewicz, Katarzyna Tota-Glowczyk, Mariusz Papp, Marco A Riva, Raffaella Molteni
Background: Psychiatric disorders are associated with altered function of inhibitory neurotransmission within the limbic system, which may be due to the vulnerability of selective neuronal subtypes to challenging environmental conditions, such as stress. In this context, parvalbumin (PVB) positive GABAergic interneurons, which are critically involved in processing complex cognitive tasks, are particularly vulnerable to stress exposure, an effect that may be the consequence of dysregulated redox mechanisms...
May 18, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29762677/anti-dementia-drugs-for-psychopathology-and-cognitive-impairment-in-schizophrenia-a-systematic-review-and-meta-analysis
#3
Taro Kishi, Toshikazu Ikuta, Kazuto Oya, Shinji Matsunaga, Yuki Matsuda, Nakao Iwata
Background: We conducted a systematic review and meta-analysis of double-blind, randomized, placebo-controlled trials of anti-dementia drugs plus antipsychotics (ADD+AP) for schizophrenia. Methods: Primary outcomes of efficacy and safety included improving overall symptoms (Positive and Negative Syndrome Scale and Brief Psychiatric Rating Scale scores) and all-cause discontinuation, respectively. Other outcomes included psychopathology subscales (positive, negative, general, and anxiety/depressive symptoms), cognitive function (attention/vigilance, reasoning/problem solving, social cognition, speed of processing, verbal learning, visual learning, working memory, and cognitive control/executive function), Mini-Mental State Examination (MMSE) scores, treatment discontinuation due to adverse events and inefficacy, and individual adverse events...
May 14, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29762664/behavioral-and-serotonergic-changes-in-the-frontal-cortex-following-methamphetamine-self-administration
#4
Lisa M McFadden, Rebecca Cordie, Tamee Livermont, Andrew Johansen
Background: Methamphetamine (METH) use is associated with a variety of negative health outcomes including psychosis. The frontal cortex serotonin (5-HT)-2 receptors are thought to contribute to psychosis-like behaviors. This study investigated changes in serotonergic markers in the frontal cortex following METH self-administration and hallucinogenic drug-induced behavior. Methods: Consistent with previously published studies, freely-cycling male and female rats were allowed to self-administer METH (Males: 0...
May 14, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29762671/motor-impairments-correlate-with-social-deficits-and-restricted-neuronal-loss-in-an-environmental-model-of-autism
#5
Tareq Al Sagheer, Obelia Haida, Anais Balbous, Maureen Francheteau, Emmanuel Matas, Pierre-Olivier Fernagut, Mohamed Jaber
Background: Motor impairments are amongst the earliest and most consistent signs of autism spectrum disorders (ASD) but are not used as diagnostic criteria. In addition, the relationship between motor and cognitive impairments and their respective neural substrates remain unknown. Methods: Here, we aimed at determining whether a well-acknowledged animal model of ASD, the valproic acid (VPA) model, displays motor impairments and whether they may correlate with social deficits and neuronal loss within motor brain areas...
May 12, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29746646/corticostriatal-connectivity-in-antisocial-personality-disorder-by-mao-a-genotype-and-its-relationship-to-aggressive-behavior
#6
Nathan J Kolla, Katharine Dunlop, Jeffrey H Meyer, Jonathan Downar
Background: The influence of genetic variation on resting-state neural networks represents a burgeoning line of inquiry in psychiatric research. Monoamine oxidase A, an X-linked gene, is one example of a molecular target linked to brain activity in psychiatric illness. Monoamine oxidase A genetic variants, including the high and low variable nucleotide tandem repeat polymorphisms, have been shown to differentially affect brain functional connectivity in healthy humans. However, it is currently unknown whether these same polymorphisms influence resting-state brain activity in clinical conditions...
May 9, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29718262/ketamine-effects-on-eeg-during-therapy-of-treatment-resistant-generalized-anxiety-and-social-anxiety
#7
Shabah Mohammad Shadli, Tame Kawe, Daniel Martin, Neil McNaughton, Shona Neehoff, Paul Glue
Background: Ketamine is swiftly effective in a range of neurotic disorders that are resistant to conventional antidepressant and anxiolytic drugs. The neural basis for its therapeutic action is unknown. Here we report the effects of ketamine on the EEG of patients with treatment-resistant generalized anxiety and social anxiety disorders. Methods: Twelve patients with refractory DSM-IV generalized anxiety disorder and/or social anxiety disorder provided EEG during 10 minutes of relaxation before and 2 hours after receiving double-blind drug administration...
April 24, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29688411/relevance-of-rodent-models-of-depression-in-clinical-practice-can-we-overcome-the-obstacles-in-translational-neuropsychiatry
#8
Johan Söderlund, Maria Lindskog
The diagnosis of a mental disorder generally depends on clinical observations and phenomenological symptoms reported by the patient. The definition of a given diagnosis is criteria based and relies on the ability to accurately interpret subjective symptoms and complex behavior. This type of diagnosis comprises a challenge to translate to reliable animal models, and these translational uncertainties hamper the development of new treatments. In this review, we will discuss how depressive-like behavior can be induced in rodents, and the relationship between these models and depression in humans...
April 23, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29688389/modulation-of-gsk-3%C3%AE-%C3%AE-catenin-signaling-contributes-to-learning-and-memory-impairment-in-a-rat-model-of-depression
#9
Jiaojie Hui, Jianping Zhang, Mengjia Pu, Xingliang Zhou, Liang Dong, Xuqiang Mao, Guofeng Shi, Jian Zou, Jingjing Wu, Dongmei Jiang, Guangjun Xi
Background: It is widely accepted that cognitive processes, such as learning and memory, are affected in depression, but the molecular mechanisms underlying the interactions of these 2 disorders are not clearly understood. Recently, glycogen synthase kinase-3 beta (GSK-3β)/β-catenin signaling was shown to play an important role in the regulation of learning and memory. Methods: The present study used a rat model of depression, chronic unpredictable stress, to determine whether hippocampal GSK-3β/β-catenin signaling was involved in learning and memory alterations...
April 23, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29688548/the-genetics-of-treatment-resistant-depression-a-critical-review-and-future-perspectives
#10
Chiara Fabbri, Filippo Corponi, Daniel Souery, Siegfried Kasper, Stuart Montgomery, Joseph Zohar, Dan Rujescu, Julien Mendlewicz, Alessandro Serretti
Background: One-third of depressed patients develop treatment-resistant depression with the related sequelae in terms of poor functionality and worse prognosis. Solid evidence suggests that genetic variants are potentially valid predictors of antidepressant efficacy and could be used to provide personalized treatments. Methods: The present review summarizes genetic findings of treatment-resistant depression including results from candidate gene studies and genome-wide association studies...
April 21, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29668939/matrine-exerts-antidepressant-like-effects-on-mice-role-of-the-hippocampal-pi3k-akt-mtor-signaling
#11
Zhonghua Wu, Zhengchen You, Peng Chen, Cheng Chen, Fei Chen, Jianhong Shen, Hui Xu
Background: Current antidepressants in clinical use always take weeks or even months to exert full therapeutic effects, and sometimes have serious side effects. Thus, it is very necessary to develop novel antidepressants with better efficacy and fewer adverse effects. The present study focused on investigating the antidepressant potential of matrine and its possible mechanisms of action. Methods: The forced swim test, tail suspension test, and chronic unpredictable mild stress model of depression were used to reveal the antidepressant-like effects of matrine on mice...
April 16, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29668918/glutamatergic-signaling-drives-ketamine-mediated-response-in-depression-evidence-from-dynamic-causal-modeling
#12
Jessica R Gilbert, Julia S Yarrington, Kathleen E Wills, Allison C Nugent, Carlos A Zarate
Background: The glutamatergic modulator ketamine has rapid antidepressant effects in individuals with major depressive disorder (MDD) and bipolar depression. Thus, modulating glutamatergic transmission may be critical to effectively treating depression, though the mechanisms by which this occurs are not fully understood. Methods: This double-blind, crossover, placebo-controlled study analyzed data from 18 drug-free MDD subjects and 18 heathy controls who received a single intravenous infusion of ketamine hydrochloride (0...
April 13, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29659870/corrigendum
#13
(no author information available yet)
No abstract text is available yet for this article.
April 6, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29635340/structurally-related-kappa-opioid-receptor-agonists-with-substantial-differential-signaling-bias-neuroendocrine-and-behavioral-effects-in-c57bl6-mice
#14
Amelia D Dunn, Brian Reed, Catherine Guariglia, Alexandra M Dunn, Joshua M Hillman, Mary Jeanne Kreek
Background: The kappa opioid receptor (KOR) system has been revealed as a potential pharmacotherapeutic target for the treatment of addictions to substances of abuse. KOR agonists have been shown to block the rewarding and dopamine-releasing effects of psychostimulants. Recent investigations have profiled the in vivo effects of compounds biased towards G-protein mediated signaling, with less potent arrestin mediated signaling. The compounds studied here derive from a series of trialkylamines: N-substituted-N- phenylethyl-N-3-hydroxyphenylethyl-amine, with N-substituents including n-butyl (BPHA), methylcyclobutyl (MCBPHA), and methylcyclopentyl (MCPPHA)...
April 4, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29618012/dopamine-modulates-the-efficiency-of-sensory-evidence-accumulation-during-perceptual-decision-making
#15
Christian Beste, Nico Adelhöfer, Krutika Gohil, Susanne Passow, Veit Roessner, Shu-Chen Li
Background: Perceptual decision making is the process through which available sensory information is gathered and processed to guide our choices. However, the neuropsychopharmacological basis of this important cognitive function is largely elusive. Yet, theoretical considerations suggest that the dopaminergic system may play an important role. Methods: In a double-blind, randomized, placebo-controlled study design, we examined the effect of methylphenidate in 2 dosages (0...
April 2, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29618019/differential-expression-of-synapsin-i-and-ii-upon-treatment-by-lithium-and-valproic-acid-in-various-brain-regions
#16
Hetshree Joshi, Roohie Sharma, Shreya Prashar, Joella Ho, Sharon Thomson, Ram Mishra
Introduction: Due to the heterogeneity of psychiatric illnesses and overlapping mechanisms, patients with psychosis are differentially responsive to pharmaceutical drugs. In addition to having therapeutic effects for schizophrenia and bipolar disorder, antipsychotics and mood stabilizers have many clinical applications and are used unconventionally due to their direct and indirect effects on neurotransmitters. Synapsins, a family of neuronal phosphoproteins, play a key regulatory role in neurotransmitter release at synapses...
March 30, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29618006/dysfunction-of-serotoninergic-and-dopaminergic-neuronal-systems-in-the-antidepressant-resistant-impairment-of-social-behaviors-induced-by-social-defeat-stress-exposure-as-juveniles
#17
Sho Hasegawa, Yuriko Miyake, Akira Yoshimi, Akihiro Mouri, Hirotake Hida, Kiyofumi Yamada, Norio Ozaki, Toshitaka Nabeshima, Yukihiro Noda
Background: Extensive studies have been performed on the role of monoaminergic neuronal systems in rodents exposed to social defeat stress as adults. In the present study, we investigated the role of monoaminergic neuronal systems in the impairment of social behaviors induced by social defeat stress exposure as juveniles. Methods: Juvenile, male C57BL/6J mice were exposed to social defeat stress for 10 consecutive days. From 1 day after the last stress exposure, desipramine, sertraline, and aripiprazole, were administered for 15 days...
March 29, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29596661/mitochondrial-agents-for-bipolar-disorder
#18
Círia Pereira, Victor Chavarria, João Vian, Melanie Maree Ashton, Michael Berk, Wolfgang Marx, Olivia May Dean
Background: Bipolar disorder is a chronic and often debilitating illness. Current treatment options (both pharmaco- and psychotherapy) have shown efficacy, but for many leave a shortfall in recovery. Advances in the understanding of the pathophysiology of bipolar disorder suggest that interventions that target mitochondrial dysfunction may provide a therapeutic benefit. Methods: This review explores the current and growing theoretical rationale as well as existing preclinical and clinical data for those therapies aiming to target the mitochondrion in bipolar disorder...
March 27, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29584866/levels-of-serum-brain-derived-neurotropic-factor-in-individuals-at-ultra-high-risk-for-psychosis-findings-from-the-longitudinal-youth-at-risk-study-lyriks
#19
Jie Yin Yee, Tih-Shih Lee, Jimmy Lee
Background: Identifying biomarkers to enrich prognostication and risk predictions in individuals at high risk of developing psychosis will enable stratified early intervention efforts. Brain-derived neurotrophic factor (BDNF) has been widely studied in schizophrenia and in first-episode psychosis with promising results. The aim of this study was to examine the levels of serum BDNF between healthy controls and individuals with ultra-high risk of psychosis (UHR). Methods: A sample of 106 healthy controls and 105 UHR individuals from the Longitudinal Youth at Risk Study was included in this study...
March 23, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29579222/inhibition-of-fatty-acid-amide-hydrolase-by-pf-3845-alleviates-the-nitrergic-and-proinflammatory-response-in-rat-hippocampus-following-acute-stress
#20
Hsiao-Jou Cortina Chen, Jereme G Spiers, Conrad Sernia, Nickolas A Lavidis
Background: Long term exposure to stress has been demonstrated to cause neuroinflammation through a sustained overproduction of free radicals, including nitric oxide, via an increased inducible nitric oxide synthase (iNOS) activity. We have previously demonstrated that iNOS activity and mRNA are significantly upregulated in the rat hippocampus following just 4 hours of restraint stress. Similar to nitric oxide, endocannabinoids are synthesised on demand, with preclinical observations suggesting that cannabinoid receptor agonists and endocannabinoid enhancers inhibit nitrergic activity...
March 22, 2018: International Journal of Neuropsychopharmacology
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