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International Journal of Neuropsychopharmacology

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https://www.readbyqxmd.com/read/28204607/aripiprazole-once-monthly-400-mg-comparison-of-pharmacokinetics-tolerability-and-safety-of-deltoid-versus-gluteal-administration
#1
Arash Raoufinia, Timothy Peters-Strickland, Anna-Greta Nylander, Ross A Baker, Anna Eramo, Na Jin, Patricia Bricmont, Jennifer Repella, Robert D McQuade, Peter Hertel, Frank Larsen
No abstract text is available yet for this article.
February 15, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28204487/cry-baby-cry-expression-of-distress-as-a-biomarker-and-modulator-in-autism-spectrum-disorder
#2
Gianluca Esposito, Noboru Hiroi, Maria Luisa Scattoni
No abstract text is available yet for this article.
February 15, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28201726/discontinuation-efficacy-and-safety-of-cholinesterase-inhibitors-for-alzheimer-s-disease-a-meta-analysis-and-meta-regression-of-44-randomized-clinical-trials-enrolling-16-245-patients
#3
Lídia Blanco-Silvente, Xavier Castells, Marc Saez, Maria Antònia Barceló, Josep Garre-Olmo, Joan Vilalta-Franch, Dolors Capellà
No abstract text is available yet for this article.
February 13, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28199677/use-of-a-spin-strategy-can-result-in-unreliable-research-findings
#4
Yasuyuki Okumura
No abstract text is available yet for this article.
February 11, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28199666/the-role-of-dopamine-d1-and-d3-receptors-in-n-methyl-d-aspartate-nmda-glycineb-site-regulated-complex-cognitive-behaviors-following-repeated-morphine-administration
#5
Yunpeng Wang, Fangyuan Yin, Hao Guo, Jing Zhang, Peng Yan, Jianghua Lai
No abstract text is available yet for this article.
February 11, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28177082/5-ht2a-agonists-a-novel-therapy-for-functional-neurological-disorders
#6
Alexander Bryson, Olivia Carter, Trevor Norman, Richard Kanaan
No abstract text is available yet for this article.
February 8, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28177081/the-working-memory-and-dorsolateral-prefrontal-hippocampal-functional-connectivity-changes-in-long-term-survival-breast-cancer-patients-treated-with-tamoxifen
#7
Xingui Chen, Xiaoxuan He, Longxiang Tao, Jingjing Li, Jiaonan Wu, Chunyan Zhu, Fengqiong Yu, Lei Zhang, Jingjie Zhang, Bensheng Qiu, Yongqiang Yu, Kai Wang
No abstract text is available yet for this article.
February 8, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28165131/structural-integrity-in-the-sustained-antidepressant-effect-of-ketamine
#8
Pauline Belujon
No abstract text is available yet for this article.
February 6, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28165117/decreased-nucleus-accumbens-expression-of-psychiatric-disorder-risk-gene-cacna1c-promotes-susceptibility-to-social-stress
#9
Chantelle E Terrillion, T Chase Francis, Adam C Puche, Mary Kay Lobo, Todd D Gould
No abstract text is available yet for this article.
February 6, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28158790/igfbp2-produces-rapid-acting-and-long-lasting-effects-in-rat-models-of-post-traumatic-stress-disorder-via-a-novel-mechanism-associated-with-structural-plasticity
#10
Jeffrey Burgdorf, Elizabeth M Colechio, Nayereh Ghoreishi-Haack, Amanda L Gross, Christopher S Rex, Xiao-Lei Zhang, Patric K Stanton, Roger A Kroes, Joseph R Moskal
No abstract text is available yet for this article.
February 1, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28158734/activation-of-extracellular-signal-regulated-kinases-erk-1-2-in-the-locus-coeruleus-contributes-to-pain-related-anxiety-in-arthritic-male-rats
#11
Gisela Borges, Cristina Miguelez, Fani Neto, Juan Antonio Micó, Luisa Ugedo, Esther Berrocoso
No abstract text is available yet for this article.
February 1, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28158336/distinct-antidepressant-like-and-cognitive-effects-of-antidepressants-with-different-mechanisms-of-action-in-middle-aged-female-mice
#12
Yan Li, Connie Sanchez, Maria Gulinello
No abstract text is available yet for this article.
February 1, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28158462/nmda-glutamate-receptor-antagonism-and-the-heritable-risk-for-alcoholism-new-insights-from-a-study-of-nitrous-oxide
#13
John H Krystal, Ismene L Petrakis, Stephanie O'Malley, Suchitra Krishnan-Sarin, Godfrey Pearlson, Gihyun Yoon
No abstract text is available yet for this article.
January 31, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28034961/role-of-prefrontal-serotonergic-and-dopaminergic-systems-in-encounter-induced-hyperactivity-in-methamphetamine-sensitized-mice
#14
Tatsunori Tanaka, Yukio Ago, Chiaki Umehara, Emina Imoto, Shigeru Hasebe, Hitoshi Hashimoto, Kazuhiro Takuma, Toshio Matsuda
BACKGROUND: Isolation-reared mice show social encounter-induced hyperactivity with activation of prefrontal serotonergic and dopaminergic systems, but it is not known whether this stress response is observed in other pathological conditions. Here we examined whether the social encounter stimulation induces abnormal behavior during withdrawal in chronic methamphetamine (METH)-treated mice. METHODS: To induce METH-induced behavioral sensitization, male mice were injected with METH (1 mg/kg) once daily for 7 days...
December 29, 2016: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28034960/elevated-dna-oxidation-and-dna-repair-enzyme-expression-in-brain-white-matter-in-major-depressive-disorder
#15
Attila Szebeni, Katalin Szebeni, Timothy P DiPeri, Luke A Johnson, Craig A Stockmeier, Jessica D Crawford, Michelle J Chandley, Liza J Hernandez, Katherine C Burgess, Russell W Brown, Gregory A Ordway
BACKGROUND: Pathology of white matter in brains of patients with major depressive disorder (MDD) is well-documented, but the cellular and molecular basis of this pathology are poorly understood. METHODS: Levels of DNA oxidation and gene expression of DNA damage repair enzymes were measured in Brodmann area 10 (BA10) and/or amygdala (uncinate fasciculus) white matter tissue from brains of MDD (n=10) and psychiatrically normal control donors (n=13). DNA oxidation was also measured in BA10 white matter of schizophrenia donors (n=10) and in prefrontal cortical white matter from control rats (n=8) and rats with repeated stress-induced anhedonia (n=8)...
December 29, 2016: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27927740/chronic-vortioxetine-treatment-reduces-exaggerated-expression-of-conditioned-fear-memory-and-restores-active-coping-behavior-in-chronically-stressed-rats
#16
Lauren Hatherall, Connie Sánchez, David A Morilak
BACKGROUND: Stress is a risk factor for depression and anxiety disorders, disrupting neuronal processes leading to exaggerated fear and compromised coping behaviors. Current antidepressants are only partially effective. Vortioxetine, a novel multimodal antidepressant, is a serotonin transporter inhibitor; 5-HT3, 5-HT7, and 5-HT1D receptor antagonist; 5-HT1B partial agonist; and 5-HT1A agonist. We have shown that chronic dietary vortioxetine administration reversed stress-induced deficits in cognitive flexibility...
December 29, 2016: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27927738/altered-acoustic-startle-reflex-prepulse-inhibition-and-peripheral-brain-derived-neurotrophic-factor-in-morphine-self-administered-rats
#17
Bong Hyo Lee, Thomas Y Park, Erica Lin, He Li, Chae Ha Yang, Kwang H Choi
BACKGROUND: Previous studies suggested that opiate withdrawal may increase anxiety and disrupt brain-derived neurotrophic factor function, but the effects of i.v. morphine self-administration on these measures remain unclear. METHODS: Adult male Sprague-Dawley rats were implanted with a catheter in the jugular vein. After 1 week of recovery, the animals were allowed to self-administer either i.v. morphine (0.5 mg/kg per infusion, 4 h/d) or saline in the operant conditioning chambers...
December 29, 2016: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28031269/indications-of-success-strategies-for-utilizing-neuroimaging-biomarkers-in-cns-drug-discovery-and-development-cinp-jsnp-working-group-report
#18
REVIEW
Tetsuya Suhara, Shigeyuki Chaki, Haruhide Kimura, Makoto Furusawa, Mitsuyuki Matsumoto, Hiroo Ogura, Takaaki Negishi, Takeaki Saijo, Makoto Higuchi, Tomohiro Omura, Rira Watanabe, Sosuke Miyoshi, Noriaki Nakatani, Noboru Yamamoto, Shyh-Yuh Liou, Yuhei Takado, Jun Maeda, Yasumasa Okamoto, Yoshiaki Okubo, Makiko Yamada, Hiroshi Ito, Noah M Walton, Shigeto Yamawaki
Despite large unmet medical needs in the field for several decades, central nervous system (CNS) drug discovery and development has been largely unsuccessful. Biomarkers, particularly those utilizing neuroimaging, have played important roles in aiding CNS drug development, including dosing determination of investigational new drugs (INDs). The utility of biomarkers as tools to overcome issues of CNS drug development is the subject for this review.In this review aimed at employing biomarkers as tools to overcome issues surrounding CNS drug development, we first analyzed problems in utilizing biomarkers in processes of drug discovery and development for CNS disorders...
December 28, 2016: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28031268/distinct-roles-of-opioid-and-dopamine-systems-in-lateral-hypothalamic-intracranial-self-stimulation
#19
Soichiro Ide, Takehiro Takahashi, Yukio Takamatsu, George R Uhl, Hiroaki Niki, Ichiro Sora, Kazutaka Ikeda
BACKGROUND: Opioid and dopamine systems play crucial roles in reward. Similarities and differences in the neural mechanisms of reward that are mediated by these two systems have remained largely unknown. Thus, in the present study, we investigated the differences in reward function in both µ-opioid receptor knockout (MOP KO) mice and dopamine transporter knockout (DAT KO) mice, important molecules in the opioid and dopamine systems. METHODS: Mice were implanted with electrodes into the right lateral hypothalamus (lh)...
December 28, 2016: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27816941/the-international-college-of-neuro-psychopharmacology-cinp-treatment-guidelines-for-bipolar-disorder-in-adults-cinp-bd-2017-part-2-review-grading-of-the-evidence-and-a-precise-algorithm
#20
REVIEW
Konstantinos N Fountoulakis, Lakshmi Yatham, Heinz Grunze, Eduard Vieta, Allan Young, Pierre Blier, Siegfried Kasper, Hans Jurgen Moeller
BACKGROUND: The current paper includes a systematic search of the literature, a detailed presentation of the results, and a grading of treatment options in terms of efficacy and tolerability/safety. MATERIAL AND METHODS: The PRISMA method was used in the literature search with the combination of the words 'bipolar,' 'manic,' 'mania,' 'manic depression,' and 'manic depressive' with 'randomized,' and 'algorithms' with 'mania,' 'manic,' 'bipolar,' 'manic-depressive,' or 'manic depression...
December 22, 2016: International Journal of Neuropsychopharmacology
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