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International Journal of Neuropsychopharmacology

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https://www.readbyqxmd.com/read/27816941/the-international-college-of-neuro-psychopharmacology-cinp-treatment-guidelines-for-bipolar-disorder-in-adults-cinp-bd-2017-part-2-review-grading-of-the-evidence-and-a-precise-algorithm
#1
REVIEW
Konstantinos N Fountoulakis, Lakshmi Yatham, Heinz Grunze, Eduard Vieta, Allan Young, Pierre Blier, Siegfried Kasper, Hans Jurgen Moeller
BACKGROUND: The current paper includes the systematic search of the literature, the detailed presentation of the results and the grading of treatment options in terms of efficacy and tolerability/safety. MATERIAL AND METHODS: The PRISMA method was used in the search of the literature with the combination of the words 'bipolar', 'manic', 'mania', 'manic depression' and 'manic depressive' with 'randomized', and 'algorithms' with 'mania', 'manic', 'bipolar', 'manic-depressive' or 'manic depression'...
November 5, 2016: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27816940/does-methylphenidate-reduce-testosterone-levels-in-humans-a-prospective-study-in-children-with-attention-deficit-hyperactivity-disorder
#2
Liang-Jen Wang, Miao-Chun Chou, Wen-Jiun Chou, Min-Jing Lee, Pao-Yen Lin, Sheng-Yu Lee, Yi-Hsuan Lee
BACKGROUND: Animal studies and case reports have suggested that methylphenidate (MPH) exerts adverse effects on gonadal hormones. This study aimed to determine whether MPH alters testosterone levels in children with attention-deficit/hyperactivity disorder (ADHD) through comparison of those with or without MPH treatment. METHODS: This 4-week, nonrandomized, prospective study conducted in Taiwan included 203 ADHD patients with a mean age of 8.7 years (boys: 75.8%)...
November 5, 2016: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27815417/dopamine-d1-and-d3-receptors-modulate-heroin-induced-cognitive-impairment-through-opponent-actions-in-mice
#3
Yongsheng Zhu, Yunpeng Wang, Jianghua Lai, Shuguang Wei, Hongbo Zhang, Peng Yan, Yunxiao Li, Xiaomeng Qiao, Fangyuan Yin
BACKGROUND: Chronic abuse of heroin leads to long-lasting and complicated cognitive impairment. Dopamine receptors are critically involved in the impulsive drug-driven behaviour and the altered attention, processing speed and mental flexibility that are associated with higher relapse rates. However, the effects of the different dopamine receptors and their possible involvement in heroin-induced cognitive impairment remain unclear. METHODS: The 5-choice serial reaction time task (5-CSRTT) was used to investigate the profiles of heroin-induced cognitive impairment in mice...
November 4, 2016: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27815416/s-ketamine-rapidly-reverses-synaptic-and-vascular-deficits-of-hippocampus-in-genetic-animal-model-of-depression
#4
Maryam Ardalan, Gregers Wegener, Ali H Rafati, Jens R Nyengaard
BACKGROUND: The neurovascular plasticity of hippocampus is an important theory underlying major depression. Ketamine as a novel glutamatergic antidepressant drug can induce rapid antidepressant effect within hours. In a mechanistic proof-of-this concept, we examined whether ketamine leads to an increase in synaptogenesis and vascularization within 24 hours after a single injection in a genetic rat model of depression. METHODS: Flinders Sensitive Line (FSL) and Flinders Resistant Line (FRL) rats were given a single intraperitoneal injection of ketamine (15 mg/kg) or saline...
November 4, 2016: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27815415/reduction-of-cocaine-induced-locomotor-effects-by-enriched-environment-is-associated-with-cell-specific-accumulation-of-%C3%AE-fosb-in-striatal-and-cortical-subregions
#5
Audrey Lafragette, Michael T Bardo, Virginie Lardeux, Marcello Solinas, Nathalie Thiriet
BACKGROUND: Early exposure to enriched environments (EE) has been shown to decrease the locomotor effects induced by repeated injections of cocaine and to modify basal and cocaine-induced total protein levels of the transcription factor delta-FosB (ΔFosB) in the whole striatum of mice. In this study, we aimed at characterizing whether the profile of ΔFosB accumulation induced by EE and cocaine would be similar or different in terms of brain areas and cell type. METHODS: We used mice expressing the eGFP protein in D1 receptor positive (D1R(+)) neurons to determine whether ΔFosB induced by EE or cocaine injections (5X15mg/kg) would occur in selective sub-populations of neurons in several sub-regions of the striatum and prefrontal cortex...
November 4, 2016: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27815414/the-international-college-of-neuropsychopharmacology-cinp-treatment-guidelines-for-bipolar-disorder-in-adults-cinp-bd-2017-part-1-background-and-methods-of-the-development-of-guidelines
#6
REVIEW
Konstantinos N Fountoulakis, Allan Young, Lakshmi Yatham, Heinz Grunze, Eduard Vieta, Pierre Blier, Hans Jurgen Moeller, Siegfried Kasper
BACKGROUND: This paper includes a short description of the important clinical aspects of Bipolar Disorder with emphasis on issues that are important for the therapeutic considerations, including mixed and psychotic features, predominant polarity, and rapid cycling as well as comorbidity. METHODS: The workgroup performed a review and critical analysis of the literature concerning grading methods and methods for the development of guidelines. RESULTS: The workgroup arrived at a consensus to base the development of the guideline on randomized controlled trials and related meta-analyses alone in order to follow a strict evidence-based approach...
November 4, 2016: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27811136/serum-brain-derived-neurotrophic-factors-in-taiwanese-patients-with-drug-na%C3%A3-ve-first-episode-major-depressive-disorder-effects-of-antidepressants
#7
Yu-Jie Chiou, Tiao-Lai Huang
BACKGROUND: Brain-derived neurotrophic factors (BDNF) are known to be related to the psychopathology of major depressive disorder (MDD). However, studies focusing on drug-naïve first-episode patients are still rare. METHODS: Over a six-year period, we examined the serum BDNF levels in patients with ?rst-episode drug-naïve MDD and compared them to sex-matched healthy controls. We also investigated the relationships between serum BDNF levels, suicidal behavior, Hamilton Depression Rating Scale (HDRS) scores before and after a 4-week antidepressant treatment...
November 3, 2016: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27806991/hippocampal-perineuronal-nets-are-required-for-the-sustained-antidepressant-effect-of-ketamine
#8
Jennifer J Donegan, Daniel J Lodge
BACKGROUND: NMDA receptor antagonists, like ketamine, produce a rapid-acting and long-lasting antidepressant effect. Although the mechanism is not completely understood, ketamine is thought to preferentially target NMDA receptors on fast-spiking parvalbumin (PV)-containing interneurons. The function of PV-containing interneurons is dependent on perineuronal nets, a specialized form of extracellular matrix that surrounds these cells. METHODS: Chondroitinase was used to enzymatically degrade perineuronal nets surrounding PV-containing interneurons in the ventral hippocampus (vHipp), a region that is involved in the antidepressant response to ketamine...
November 2, 2016: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27765808/rapid-and-sustained-antidepressant-action-of-the-mglu2-3-receptor-antagonist-mgs0039-in-the-social-defeat-stress-model-comparison-with-ketamine
#9
Chao Dong, Ji-Chun Zhang, Wei Yao, Qian Ren, Min Ma, Chun Yang, Shigeyuki Chaki, Kenji Hashimoto
BACKGROUND: Similar to the N-methyl-D-aspartate receptor antagonist ketamine, the metabotropic glutamate 2/3 receptor antagonist, MGS0039, shows antidepressant effects. However, there are no reports comparing these 2 compounds in the social defeat stress model of depression. METHODS: We examined the effects of MGS0039 (1 mg/kg) and ketamine (10 mg/kg) on depression-like behavior in susceptible mice after repeated social defeat stress. Protein levels of brain-derived neurotrophic factor, TrkB, phospho-TrkB, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (GluA1), postsynaptic density protein 95, and dendritic spine density in selected brain regions were measured...
October 27, 2016: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27784751/switching-from-inadequate-adjunctive-or-combination-treatment-options-to-brexpiprazole-adjunctive-to-antidepressant-an-open-label-study-on-the-effects-on-depressive-symptoms-and-cognitive-and-physical-functioning
#10
Maurizio Fava, Takao Okame, Yuki Matsushima, Pamela Perry, Emmanuelle Weiller, Ross A Baker
BACKGROUND: Approximately 50% of patients with major depressive disorder (MDD) do not respond adequately to their antidepressant treatment (ADT), underscoring the need for more effective treatment options. The objective of this study was to investigate the effect of adjunctive brexpiprazole on depressive symptoms in patients with MDD who were not responding to adjunctive or combination therapy of their current ADTs with several different classes of agents (NCT02012218). METHODS: In this 6-week, open-label, phase 3b study, patients with MDD who had an inadequate response to ≥1 adjunctive or combination therapy, in addition to history of ≥1 failure to monotherapy ADT, were switched to adjunctive brexpiprazole...
October 26, 2016: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27744406/long-lasting-impairment-of-mglur5-activated-intracellular-pathways-in-the-striatum-after-withdrawal-of-cocaine-self-administration
#11
Hanne Mette Hoffmann, Nadine Crouzin, Estefanía Moreno, Noora Raivio, Silvia Fuentes, Peter J McCormick, Jordi Ortiz, Michel Vignes
BACKGROUND: Cocaine addiction continues to be a major heath concern, and despite public health intervention there is a lack of efficient pharmacological treatment options. A newly identified potential target are the group I metabotropic glutamate receptors (mGluR1/5), with allosteric modulators showing particular promise. METHODS: We evaluated the capacity of mGluR1/5 receptors to induce functional responses in ex vivo striatal slices from rats with 1) acute cocaine self-administration (CSA), 2) chronic CSA and 3) 60 days CSA withdrawal by westernblot and extracellular recordings of synaptic transmission...
October 15, 2016: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27742833/exposure-response-relationships-during-free-access-intravenous-alcohol-self-administration-in-non-dependent-drinkers-influence-of-alcohol-expectancies-and-impulsivity
#12
Bethany L Stangl, Vatsalya Vatsalya, Molly R Zametkin, Megan E Cooke, Martin H Plawecki, Sean O'Connor, Vijay A Ramchandani
BACKGROUND: Self-administration is a hallmark of all addictive drugs, including alcohol. Human laboratory models of alcohol self-administration have characterized alcohol-seeking behavior, and served as surrogate measures of the effectiveness of pharmacotherapies for alcohol use disorders. Intravenous alcohol self-administration (IV-ASA) is a novel method that assess alcohol exposure driven primarily by the pharmacological response to alcohol, and may have utility in characterizing unique behavioral and personality correlates of alcohol-seeking and consumption...
October 14, 2016: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27566723/efficacy-and-safety-of-brexpiprazole-opc-34712-as-maintenance-treatment-in-adults-with-schizophrenia-a-randomized-double-blind-placebo-controlled-study
#13
W Wolfgang Fleischhacker, Mary Hobart, John Ouyang, Andy Forbes, Stephanie Pfister, Robert D McQuade, William H Carson, Raymond Sanchez, Margareta Nyilas, Emmanuelle Weiller
BACKGROUND: Brexpiprazole has previously demonstrated efficacy in acute schizophrenia trials. The objective of this trial was to assess the efficacy, safety, and tolerability of maintenance treatment with brexpiprazole in adults with schizophrenia. METHODS: Patients with an acute exacerbation of psychotic symptoms were converted to brexpiprazole (1-4mg/d) over 1 to 4 weeks and entered a single-blind stabilization phase. Those patients who met stability criteria for 12 weeks were randomized 1:1 to double-blind maintenance treatment with either brexpiprazole (at their stabilization dose) or placebo for up to 52 weeks...
October 13, 2016: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27729466/bdnf-gsk-3%C3%AE-%C3%AE-catenin-pathway-in-the-mpfc-is-involved-in-antidepressant-like-effects-of-morinda-officinalis-oligosaccharides-in-rats
#14
Xu Ling-Zhi, Xu De-Feng, Han Ying, Liu Li-Jing, Sun Cheng-Yu, Deng Jia-Hui, Zhang Ruo-Xi, Yuan Ming, Zhang Su-Zhen, Li Zhi-Meng, Xu Yi, Li Jin-Sheng, Xie Su-Hua, Li Su-Xia, Zhang Hong-Yan, Lu Lin
BACKGROUND: Morinda officinalis oligosaccharides (MOs) have been reported to exert neuroprotective and antidepressant-like effects in the forced swim test (FST) in mice. However, the mechanisms that underlie the antidepressant-like effects of MOs are unclear. METHODS: Chronic unpredictable stress (CUS) and FST were used to explore the antidepressant-like effects of MOs and resilience to stress in rats. The PI3K inhibitor LY294002 was microinjected in the medial prefrontal cortex (mPFC) to explore the role of GSK-3β in the antidepressant-like effects of MOs...
October 11, 2016: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27677983/the-international-college-of-neuropsychopharmacology-cinp-treatment-guidelines-for-bipolar-disorder-in-adults-cinp-bd-2017-part-4-unmet-needs-in-the-treatment-of-bipolar-disorder-and-recommendations-for-future-research
#15
Konstantinos N Fountoulakis, Eduard Vieta, Allan Young, Lakshmi Yatham, Heinz Grunze, Pierre Blier, Hans Jurgen Moeller, Siegfried Kasper
BACKGROUND: The current fourth paper on the International College of Neuropsychopharmacology guidelines for the treatment of bipolar disorder reports on the unmet needs that became apparent after an extensive review of the literature and also serves as a conclusion to the project of the International College of Neuropsychopharmacology workgroup. MATERIALS AND METHODS: The systematic review of the literature that was performed to develop the International College of Neuropsychopharmacology guidelines for bipolar disorder identified and classified a number of potential shortcomings...
October 11, 2016: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27639091/optimization-of-clonazepam-therapy-adjusted-to-patient-s-cyp3a-status-and-nat2-genotype
#16
Katalin Tóth, Gábor Csukly, Dávid Sirok, Ales Belic, Ádám Kiss, Edit Háfra, Máté Déri, Ádám Menus, István Bitter, Katalin Monostory
BACKGROUND: The shortcomings of clonazepam therapy include tolerance, withdrawal symptoms, and adverse effects such as drowsiness, dizziness, and confusion leading to increased risk of falls. Inter-individual variability in the incidence of adverse events in patients partly originates from the differences in clonazepam metabolism due to genetic and nongenetic factors. METHODS: Since the prominent role in clonazepam nitro-reduction and acetylation of 7-amino-clonazepam is assigned to CYP3A and N-acetyl transferase 2 enzymes, respectively, the association between the patients' CYP3A status (CYP3A5 genotype, CYP3A4 expression) or N-acetyl transferase 2 acetylator phenotype and clonazepam metabolism (plasma concentrations of clonazepam and 7-amino-clonazepam) was evaluated in 98 psychiatric patients suffering from schizophrenia or bipolar disorders...
October 3, 2016: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27638901/peripheral-serotonin-1b-receptor-transcription-predicts-the-effect-of-acute-tryptophan-depletion-on-risky-decision-making
#17
Paul Faulkner, Federico Mancinelli, Patricia L Lockwood, Mar Matarin, Raymond J Dolan, Nick W Wood, Peter Dayan, Jonathan P Roiser
BACKGROUND: The effects of acute tryptophan depletion on human decision-making suggest that serotonin modulates the processing of rewards and punishments. However, few studies have assessed which of the many types of serotonin receptors are responsible. METHODS: Using a within-subject, double-blind, sham-controlled design in 26 subjects, we examined whether individual differences in serotonin system gene transcription, measured in peripheral blood, predicted the effect of acute tryptophan depletion on decision-making...
October 3, 2016: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27608810/marmoset-serotonin-5-ht1a-receptor-mapping-with-a-biased-agonist-pet-probe-18f-f13714-comparison-with-an-antagonist-tracer-18f-mppf-in-awake-and-anesthetized-states
#18
Chihiro Yokoyama, Aya Mawatari, Akihiro Kawasaki, Chiho Takeda, Kayo Onoe, Hisashi Doi, Adrian Newman-Tancredi, Luc Zimmer, Hirotaka Onoe
BACKGROUND: In vivo mapping by positron emission tomography of the serotonin 1A receptors has been hindered by the lack of suitable agonist positron emission tomography probes. (18)F-labeled F13714 is a recently developed biased agonist positron emission tomography probe that preferentially targets subpopulations of serotonin 1A receptors in their "active state," but its brain labeling pattern in nonhuman primate has not been described. In addition, a potential confound in the translatability of PET data between nonhuman animal and human arise from the use of anesthetics that may modify the binding profiles of target receptors...
October 3, 2016: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27507301/microrna-101b-is-downregulated-in-the-prefrontal-cortex-of-a-genetic-model-of-depression-and-targets-the-glutamate-transporter-slc1a1-eaat3-in-vitro
#19
Ya Bin Wei, Philippe A Melas, J Carlos Villaescusa, Jia Jia Liu, Ning Xu, Søren Hofman Christiansen, Heidi Elbrønd-Bek, David Paul Drucker Woldbye, Gregers Wegener, Aleksander A Mathé, Catharina Lavebratt
BACKGROUND: MicroRNAs (miRNAs) are small regulatory molecules that cause translational repression by base pairing with target mRNAs. Cumulative evidence suggests that changes in miRNA expression may in part underlie the pathophysiology and treatment of neuropsychiatric disorders, including major depressive disorder (MDD). METHODS: A miRNA expression assay that can simultaneously detect 423 rat miRNAs (miRBase v.17) was used to profile the prefrontal cortex (PFC) of a genetic rat model of MDD (the Flinders Sensitive Line [FSL]) and the controls, the Flinders Resistant Line (FRL)...
September 30, 2016: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27608811/antidepressant-effects-of-mk-801-and-mk-801-in-the-social-defeat-stress-model
#20
Bangkun Yang, Qian Ren, Min Ma, Qian-Xue Chen, Kenji Hashimoto
BACKGROUND: Current data on antidepressant action of the N-methyl-D-aspartate receptor antagonist, (+)-MK-801, is inconsistent. This study was conducted to examine the effects of (+)-MK-801 and its less potent stereoisomer, (-)-MK-801, in the social defeat stress model of depression. METHODS: The antidepressant effects of (+)-MK-801 (0.1mg/kg) and (-)-MK-801 (0.1mg/kg) in the social defeat stress model were examined. RESULTS: In the tail suspension and forced swimming tests, both stereoisomers significantly attenuated increased immobility time in susceptible mice...
September 23, 2016: International Journal of Neuropsychopharmacology
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