Read by QxMD icon Read

International Journal of Neuropsychopharmacology

Hanne Mette Hoffmann, Nadine Crouzin, Estefanía Moreno, Noora Raivio, Silvia Fuentes, Peter J McCormick, Jordi Ortiz, Michel Vignes
BACKGROUND: Cocaine addiction continues to be a major heath concern, and despite public health intervention there is a lack of efficient pharmacological treatment options. A newly identified potential target are the group I metabotropic glutamate receptors (mGluR1/5), with allosteric modulators showing particular promise. METHODS: We evaluated the capacity of mGluR1/5 receptors to induce functional responses in ex vivo striatal slices from rats with 1) acute cocaine self-administration (CSA), 2) chronic CSA and 3) 60 days CSA withdrawal by westernblot and extracellular recordings of synaptic transmission...
October 15, 2016: International Journal of Neuropsychopharmacology
Bethany L Stangl, Vatsalya Vatsalya, Molly R Zametkin, Megan E Cooke, Martin H Plawecki, Sean O'Connor, Vijay A Ramchandani
BACKGROUND: Self-administration is a hallmark of all addictive drugs, including alcohol. Human laboratory models of alcohol self-administration have characterized alcohol-seeking behavior, and served as surrogate measures of the effectiveness of pharmacotherapies for alcohol use disorders. Intravenous alcohol self-administration (IV-ASA) is a novel method that assess alcohol exposure driven primarily by the pharmacological response to alcohol, and may have utility in characterizing unique behavioral and personality correlates of alcohol-seeking and consumption...
October 14, 2016: International Journal of Neuropsychopharmacology
W Wolfgang Fleischhacker, Mary Hobart, John Ouyang, Andy Forbes, Stephanie Pfister, Robert D McQuade, William H Carson, Raymond Sanchez, Margareta Nyilas, Emmanuelle Weiller
BACKGROUND: Brexpiprazole has previously demonstrated efficacy in acute schizophrenia trials. The objective of this trial was to assess the efficacy, safety, and tolerability of maintenance treatment with brexpiprazole in adults with schizophrenia. METHODS: Patients with an acute exacerbation of psychotic symptoms were converted to brexpiprazole (1-4mg/d) over 1 to 4 weeks and entered a single-blind stabilization phase. Those patients who met stability criteria for 12 weeks were randomized 1:1 to double-blind maintenance treatment with either brexpiprazole (at their stabilization dose) or placebo for up to 52 weeks...
October 13, 2016: International Journal of Neuropsychopharmacology
Xu Ling-Zhi, Xu De-Feng, Han Ying, Liu Li-Jing, Sun Cheng-Yu, Deng Jia-Hui, Zhang Ruo-Xi, Yuan Ming, Zhang Su-Zhen, Li Zhi-Meng, Xu Yi, Li Jin-Sheng, Xie Su-Hua, Li Su-Xia, Zhang Hong-Yan, Lu Lin
BACKGROUND: Morinda officinalis oligosaccharides (MOs) have been reported to exert neuroprotective and antidepressant-like effects in the forced swim test (FST) in mice. However, the mechanisms that underlie the antidepressant-like effects of MOs are unclear. METHODS: Chronic unpredictable stress (CUS) and FST were used to explore the antidepressant-like effects of MOs and resilience to stress in rats. The PI3K inhibitor LY294002 was microinjected in the medial prefrontal cortex (mPFC) to explore the role of GSK-3β in the antidepressant-like effects of MOs...
October 11, 2016: International Journal of Neuropsychopharmacology
Konstantinos N Fountoulakis, Eduard Vieta, Allan Young, Lakshmi Yatham, Heinz Grunze, Pierre Blier, Hans Jurgen Moeller, Siegfried Kasper
BACKGROUND: The current fourth paper on the International College of Neuropsychopharmacology guidelines for the treatment of bipolar disorder reports on the unmet needs that became apparent after an extensive review of the literature and also serves as a conclusion to the project of the International College of Neuropsychopharmacology workgroup. MATERIALS AND METHODS: The systematic review of the literature that was performed to develop the International College of Neuropsychopharmacology guidelines for bipolar disorder identified and classified a number of potential shortcomings...
October 11, 2016: International Journal of Neuropsychopharmacology
Chao Dong, Ji-Chun Zhang, Wei Yao, Qian Ren, Min Ma, Chun Yang, Shigeyuki Chaki, Kenji Hashimoto
BACKGROUND: Similar to the N-methyl-D-aspartate (NMDA) receptor antagonist ketamine, the metabotropic glutamate 2/3 (mGlu2/3) receptor antagonist, MGS0039 shows antidepressant effects. However, there are no reports comparing these two compounds in the social defeat stress model of depression. METHODS: We examined the effects of MGS0039 (1 mg/kg) and ketamine (10 mg/kg) on depression-like behavior in susceptible mice, after repeated social defeat stress. Protein levels of brain-derived neurotrophic factor (BDNF), TrkB, phospho-TrkB (p-TrkB), α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor (GluA1) and postsynaptic density protein 95 (PSD-95), and dendritic spine density in selected brain regions were measured...
October 7, 2016: International Journal of Neuropsychopharmacology
Katalin Tóth, Gábor Csukly, Dávid Sirok, Ales Belic, Ádám Kiss, Edit Háfra, Máté Déri, Ádám Menus, István Bitter, Katalin Monostory
BACKGROUND: The shortcomings of clonazepam therapy include tolerance, withdrawal symptoms, and adverse effects such as drowsiness, dizziness, and confusion leading to increased risk of falls. Inter-individual variability in the incidence of adverse events in patients partly originates from the differences in clonazepam metabolism due to genetic and nongenetic factors. METHODS: Since the prominent role in clonazepam nitro-reduction and acetylation of 7-amino-clonazepam is assigned to CYP3A and N-acetyl transferase 2 enzymes, respectively, the association between the patients' CYP3A status (CYP3A5 genotype, CYP3A4 expression) or N-acetyl transferase 2 acetylator phenotype and clonazepam metabolism (plasma concentrations of clonazepam and 7-amino-clonazepam) was evaluated in 98 psychiatric patients suffering from schizophrenia or bipolar disorders...
October 3, 2016: International Journal of Neuropsychopharmacology
Paul Faulkner, Federico Mancinelli, Patricia L Lockwood, Mar Matarin, Raymond J Dolan, Nick W Wood, Peter Dayan, Jonathan P Roiser
BACKGROUND: The effects of acute tryptophan depletion on human decision-making suggest that serotonin modulates the processing of rewards and punishments. However, few studies have assessed which of the many types of serotonin receptors are responsible. METHODS: Using a within-subject, double-blind, sham-controlled design in 26 subjects, we examined whether individual differences in serotonin system gene transcription, measured in peripheral blood, predicted the effect of acute tryptophan depletion on decision-making...
October 3, 2016: International Journal of Neuropsychopharmacology
Chihiro Yokoyama, Aya Mawatari, Akihiro Kawasaki, Chiho Takeda, Kayo Onoe, Hisashi Doi, Adrian Newman-Tancredi, Luc Zimmer, Hirotaka Onoe
BACKGROUND: In vivo mapping by positron emission tomography of the serotonin 1A receptors has been hindered by the lack of suitable agonist positron emission tomography probes. (18)F-labeled F13714 is a recently developed biased agonist positron emission tomography probe that preferentially targets subpopulations of serotonin 1A receptors in their "active state," but its brain labeling pattern in nonhuman primate has not been described. In addition, a potential confound in the translatability of PET data between nonhuman animal and human arise from the use of anesthetics that may modify the binding profiles of target receptors...
October 3, 2016: International Journal of Neuropsychopharmacology
Ya Bin Wei, Philippe A Melas, J Carlos Villaescusa, Jia Jia Liu, Ning Xu, Søren Hofman Christiansen, Heidi Elbrønd-Bek, David Paul Drucker Woldbye, Gregers Wegener, Aleksander A Mathé, Catharina Lavebratt
BACKGROUND: MicroRNAs (miRNAs) are small regulatory molecules that cause translational repression by base pairing with target mRNAs. Cumulative evidence suggests that changes in miRNA expression may in part underlie the pathophysiology and treatment of neuropsychiatric disorders, including major depressive disorder (MDD). METHODS: A miRNA expression assay that can simultaneously detect 423 rat miRNAs (miRBase v.17) was used to profile the prefrontal cortex (PFC) of a genetic rat model of MDD (the Flinders Sensitive Line [FSL]) and the controls, the Flinders Resistant Line (FRL)...
September 30, 2016: International Journal of Neuropsychopharmacology
Bangkun Yang, Qian Ren, Min Ma, Qian-Xue Chen, Kenji Hashimoto
BACKGROUND: Current data on antidepressant action of the N-methyl-D-aspartate receptor antagonist, (+)-MK-801, is inconsistent. This study was conducted to examine the effects of (+)-MK-801 and its less potent stereoisomer, (-)-MK-801, in the social defeat stress model of depression. METHODS: The antidepressant effects of (+)-MK-801 (0.1mg/kg) and (-)-MK-801 (0.1mg/kg) in the social defeat stress model were examined. RESULTS: In the tail suspension and forced swimming tests, both stereoisomers significantly attenuated increased immobility time in susceptible mice...
September 23, 2016: International Journal of Neuropsychopharmacology
R Dardennes, N Al Anbar, S Divac, J Cohen
No abstract text is available yet for this article.
September 21, 2016: International Journal of Neuropsychopharmacology
Kyoji Okita, Mark A Mandelkern, Edythe D London
BACKGROUND: Cigarette smoking induces dopamine release in the striatum, and smoking- or nicotine-induced ventral striatal dopamine release is correlated with nicotine dependence. Smokers also exhibit lower dopamine D2/3 (D2 and D3) receptor availability (BPND) in the dorsal striatum than nonsmokers. Negative correlations of striatal dopamine D2/3 BPND with smoking exposure and nicotine dependence, therefore, might be expected, but have not been tested. METHODS: Twenty smokers had positron emission tomography scans with [(18)F]fallypride to measure dopamine D2/3 BPND in ventral and dorsal regions of the striatum, and provided self-report Measures of recent and lifetime smoking and of nicotine dependence...
September 15, 2016: International Journal of Neuropsychopharmacology
Ana Popovic, Martin Bauer, Ulrich Sauerzopf, Lucie Bartova, Nicole Praschak-Rieder, Harald H Sitte, Siegfried Kasper, Matthäus Willeit
Sensitization is defined as a process whereby repeated intermittent exposure to a given stimulus results in an enhanced response at subsequent exposures. Next to robust findings of an increased dopamine synthesis capacity in schizophrenia, empirical data and neuroimaging studies support the notion that the mesolimbic dopamine system of patients with schizophrenia is more reactive compared to healthy controls. These studies led to the conceptualization of schizophrenia as a state of endogenous sensitization, as stronger behavioral response and increased dopamine release after amphetamine administration or exposure to stress have been observed in patients with schizophrenia...
September 9, 2016: International Journal of Neuropsychopharmacology
Matteo M Pusceddu, Philip Kelly, Catherine Stanton, John F Cryan, Timothy G Dinan
OBJECTIVE: The impact of lifetime dietary habits and their role in physical, mental, and social well-being has been the focus of considerable recent research. Omega-3 polyunsaturated fatty acids (n-3 PUFAs) as a dietary constituent have been under the spotlight for decades. n-3 PUFAs constitute key regulating factors of neurotransmission, neurogenesis, and neuroinflammation and are thereby fundamental for development, functioning and ageing of the CNS. Of note is the fact that these processes are altered in various psychiatric disorders, including attention deficit hyperactivity disorder (ADHD), depression and Alzheimer...
September 8, 2016: International Journal of Neuropsychopharmacology
Sylvain Auvity, Wadad Saba, Sébastien Goutal, Claire Leroy, Irène Buvat, Jérôme Cayla, Fabien Caillé, Michel Bottlaender, Salvatore Cisternino, Nicolas Tournier
BACKGROUND: The neuroinflammatory response to morphine exposure modulates its antinociceptive effects, tolerance and dependence. PET radioligands for translocator protein-18kDa such as [(18)F]DPA-714 are non-invasive biomarkers of glial activation, a hallmark of neuroinflammation. METHODS: [(18)F]DPA-714 PET imaging was performed in five baboons at baseline and 2 hours after intramuscular morphine injection (1 mg/kg). Brain kinetics and metabolite-corrected input function were measured to estimate [(18)F]DPA-714 brain distribution (VT)...
August 31, 2016: International Journal of Neuropsychopharmacology
S J Stringfield, J A Higginbotham, R A Fuchs
BACKGROUND: Exposure to cocaine-associated stimuli triggers a robust rise in circulating glucocorticoid levels. Glucocorticoid receptors (GR) are richly expressed in the basolateral amygdala (BLA), a brain region that controls the reinstatement of cocaine-seeking behavior upon exposure to a previously cocaine-paired environmental context. In the present study, we investigated whether GR stimulation in the BLA is integral to drug context-induced motivation to seek cocaine in a rat model of drug relapse...
August 12, 2016: International Journal of Neuropsychopharmacology
Zhi Xu, Gavin P Reynolds, Yonggui Yuan, Yanyan Shi, Mengjia Pu, Zhijun Zhang
BACKGROUND: Variation in genes implicated in monoamine neurotransmission may interact with environmental factors to influence antidepressant response. We aimed to determine how a range of single nucleotide polymorphisms (SNPs) in monoaminergic genes influence this response to treatment and how they interact with childhood trauma and recent life stress in a Chinese sample. An initial study of monoaminergic coding region SNPs identified significant associations of TPH2 and HTR1B SNPs with treatment response that showed interactions with childhood and recent life stress respectively (Xu et al, 2012)...
August 12, 2016: International Journal of Neuropsychopharmacology
Corina Nagy, Susana G Torres-Platas, Naguib Mechawar, Gustavo Turecki
BACKGROUND: Major depressive disorder (MDD) has been associated with dysfunctional astrocytic networks. The underlying causes, extent, and consequences of such dysfunctions remain to be characterized. Astrocyte-astrocyte communication occurs principally through gap junction channels primarily formed by connexin 30 and 43 (CX30 and CX43). We previously reported decreased connexin expression in the prefrontal cortex (PFC) of depressed suicides. In the present study, we investigated whether these changes are mediated by epigenetic regulation, and expanded gene expression quantifications to other cortical and subcortical regions to assess the regional distribution of connexion disruptions in depressed suicides...
August 11, 2016: International Journal of Neuropsychopharmacology
Aliou B Gueye, Yaroslaw Pryslawsky, Jose M Trigo, Nafsika Poulia, Foteini Delis, Katerina Antoniou, Michael Loureiro, Steve R Laviolette, Kiran Vemuri, Alexandros Makriyannis, Bernard Le Foll
BACKGROUND: Multiple studies suggest a pivotal role of the endocannabinoid system in regulating the reinforcing effects of various substances of abuse. Rimonabant, a CB1 inverse agonist found to be effective for smoking cessation, was associated with an increased risk of anxiety and depression. Here we evaluated the effects of the CB1 neutral antagonist AM4113 on the abuse-related effects of nicotine and its effects on anxiety and depressive-like behavior in rats. METHODS: Rats were trained to self-administer nicotine under a fixed-ratio 5 or progressive-ratio schedules of reinforcement...
August 4, 2016: International Journal of Neuropsychopharmacology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"