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International Journal of Neuropsychopharmacology

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https://www.readbyqxmd.com/read/29986038/evidence-of-reduced-agmatine-concentrations-in-the-cerebral-cortex-of-suicides
#1
Gary G Chen, Daniel Almeida, Laura Fiori, Gustavo Turecki
Background: The polyamines are a group of ubiquitous low molecular weight aliphatic molecules that play an essential role in various physiological functions of the mammalian CNS. Previous literature has indicated alterations in the expression of polyamine-related genes in the brains of individuals who died by suicide; including downregulation of spermidine/spermine N1-acetyltransferase (SAT1), a key enzyme involved in polyamine catabolism. One such polyamine, namely agmatine, has been shown to act as an anti-depressant in animal models of depressive-like behaviour...
July 9, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29986042/risk-of-neuropsychiatric-adverse-effects-of-lipid-lowering-drugs-a-mendelian-randomization-study
#2
Jahad Alghamdi, Sabine Matou-Nasri, Faisal Alghamdi, Saleh Alghamdi, Majid Alfadhel, Sandosh Padmanabhan
Background: Recent studies have highlighted the possible risk of neuropsychiatric adverse effects during lipid-lowering medications. However, there are still controversies that require a novel genetic-based approach to verify whether the impact of lipid-lowering drug treatment results in neuropsychiatric troubles including insomnia, depression, and neuroticism. Thus, we applied Mendelian randomization (MR) to assess any potential neuropsychiatric adverse effects of conventional lipid-lowering drugs such as Statins, proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, and ezetimibe...
July 7, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29986044/the-beta-arrestin-biased-dopamine-d2-receptor-ligand-unc9994-is-a-partial-agonist-at-g-protein-mediated-potassium-channel-activation
#3
Richard Ågren, Peter Århem, Johanna Nilsson, Kristoffer Sahlholm
Background: Previous evidence suggests that UNC9994 is a beta-arrestin2-selective agonist at the dopamine D2 receptor (D2R), lacking ability both to activate and to antagonize G protein-dependent signaling. However, this has only been reported by one laboratory using a single assay. Methods: We used G protein-coupled inward rectifier potassium channel (GIRK) activation in Xenopus oocytes to investigate UNC9994-induced modulation of G protein-dependent signaling at D2R and D3R...
July 6, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29982505/adult-cellular-neuroadaptations-induced-by-adolescent-thc-exposure-in-female-rats-are-rescued-by-enhancing-anandamide-signaling
#4
B Cuccurazzu, E Zamberletti, C Nazzaro, P Prini, M Trusel, M Grilli, D Parolaro, R Tonini, T Rubino
Background: In rodent models, chronic exposure to cannabis' psychoactive ingredient Δ9-tetrahydrocannabinol (THC) during adolescence leads to abnormal behavior in adulthood. In female rats, this maladaptive behavior is characterized by endophenotypes for depressive-like and psychotic-like disorders, as well as cognitive deficits. We have recently reported that most depressive-like behaviors triggered by adolescent THC exposure can be rescued by manipulating endocannabinoid signaling in adulthood with the anandamide inactivating enzyme FAAH inhibitor, URB597...
June 29, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29961822/the-impact-of-the-concept-of-treatment-resistant-depression-an-opinion-review
#5
Koen Demyttenaere, Zeno Van Duppen
Treatment-resistant depression refers to major depressive disorder, treatment of the disorder, and failure to obtain an "acceptable" outcome. Regarding the disorder, the heterogeneous concept of major depressive disorder and the multiple definitions of treatment-resistant depression, hesitating between a categorical and a more dimensional approach, as well as the divergence between diagnostic criteria and the items in the assessment scales are a source of confusion. Classifications do not take into account the dramatic influence of patient characteristics strongly impacting outcome, although these can be the cause of so-called pseudo-resistance...
June 28, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29939264/suicidal-ideation-and-suicidal-behavior-as-rare-adverse-events-of-antidepressant-medication-current-report-from-the-amsp-multicenter-drug-safety-surveillance-project
#6
Susanne Stübner, Renate Grohmann, Waldemar Greil, Xueqiong Zhang, Bruno Müller-Oerlinghausen, Stefan Bleich, Eckart Rüther, Hans-Jürgen Möller, Rolf Engel, Peter Falkai, Sermin Toto, Siegfried Kasper, Alexandra Neyazi
Background: Suicidal ideations, suicide attempts, and fatal suicides are rare adverse drug reactions to antidepressant drugs, but they essentially are clinically relevant. Drawing on a larger dataset of the European drug surveillance program, the present naturalistic study updates a previous contribution (Stübner et al., 2010). Methods: First an analysis of the comprehensive data collected in 81 psychiatric hospitals from 1993 to 2014 by the European drug surveillance program Arzneimittelsicherheit in der Psychiatrie was made...
June 22, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29924326/functional-connectivity-of-the-raphe-nuclei-link-to-tobacco-withdrawal-in-smokers
#7
Paul Faulkner, Dara G Ghahremani, Rachel F Tyndale, Gerhard Hellemann, Edythe D London
Background: Although nicotine alters serotonergic neurochemistry, clinical trials of serotonergic medications for smoking cessation have provided mixed results. Understanding the role of serotonergic dysfunction in tobacco use disorder may advance development of novel pharmacotherapies. Methods: Functional magnetic resonance imaging was used to measure resting-state functional connectivity of the raphe nuclei as an indicator of serotonergic function. Connectivity of the dorsal and median raphe nuclei was compared between 18 young smokers (briefly-abstinent, ~40 minutes post-smoking) and 19 young non-smokers (16-21 years old); connectivity was also examined in a separate sample of overnight-abstinent smokers (18-25 years old), before and after smoking the first cigarette of the day...
June 19, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29917080/association-between-cortical-gaba-and-loudness-dependence-of-auditory-evoked-potentials-ldaep-in-humans
#8
Christine Wyss, Desmond H Y Tse, Frank Boers, Jon Shah N, Irene Neuner, Wolfram Kawohl
Loudness dependence of auditory evoked potentials (LDAEP) is a widely used electroencephalography (EEG) based biomarker for central serotonergic activity. Serotonin has been shown to be associated with different psychiatric disorders such as depression and schizophrenia. Despite its clinical significance, the underlying neurochemical mechanism of this promising marker is not fully understood and further research is needed to improve its validity. Other neurotransmitters might have a significant impact on this measure...
June 15, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29905798/nicotine-induced-conditional-place-preference-is-affected-by-head-injury-correlation-with-dopamine-release-in-the-nucleus-accumbens-shell
#9
Chen Yuan-Hao, Tung-Tai Kuo, Eagle Yi-Kung Huang, Barry J Hoffer, Jen-Hsin Kao, Yu-Ching Chou, Yung-Hsiao Chiang, Jonathan Miller
Background: Traumatic brain injury (TBI) is known to impact dopamine-mediated reward pathways, but the underlying mechanisms have not been fully established. Methods: Nicotine-induced conditional place preference (CPP) was used to study rats exposed to a 6-psi fluid percussion injury (FPI) with and without prior exposure to nicotine. Preference was quantified as a score defined as (C1-C2) / (C1+C2), where C1 is time in the nicotine-paired compartment and C2 is time in the saline-paired compartment...
June 14, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29893929/no-sex-specific-differences-in-the-acute-antidepressant-actions-of-r-ketamine-in-an-inflammation-model
#10
Lijia Chang, Hidetoh Toki, Youge Qu, Yuko Fujita, Akiko Mizuno-Yasuhira, Jun-Ichi Yamaguchi, Shigeyuki Chaki, Kenji Hashimoto
Background: Although previous reports suggest sex-specific differences in the antidepressant actions of (R,S)-ketamine, these differences in the antidepressant actions of (R)-ketamine, which is more potent than (S)-ketamine, are unknown. Methods: Saline or (R)-ketamine was administered 23 hours post lipopolysaccharide (LPS) administration to adult male or female mice. Subsequently, antidepressant effects were assessed using a forced swimming test (FST). Furthermore, the concentration of (R)-ketamine and its two major metabolites, (R)-norketamine and (2R,6R)-hydroxynorketamine (HNK), was measured in the plasma and brain after the administration of (R)-ketamine in the mice...
June 9, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29860313/sigma-1-receptor-antagonists-inhibit-manic-like-behaviors-in-two-congenital-strains-of-mice
#11
Pilar Sánchez-Blázquez, Elsa Cortés-Montero, María Rodríguez-Muñoz, Javier Garzón
Background: Several currently available animal models reproduce select behavioral facets of human mania as well as the abnormal glutamatergic neurotransmission and dysregulation of glycogen synthase kinase 3β (GSK3β) that accompanies this disease. Methods: In this study, we addressed the therapeutic potential of ligands of sigma receptor type 1 (σ1R) in two putative models of mania: the "manic" Black Swiss outbred mice from Taconic farms (BStac) and mice with the 129 genetic background and histidine triad nucleotide-binding protein 1 (HINT1) deletion (HINT1-/- mice) that exhibit bipolar-like behaviors...
May 31, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29850881/monoamine-transporter-and-receptor-interaction-profiles-in-vitro-predict-reported-human-doses-of-novel-psychoactive-stimulants-and-psychedelics
#12
Dino Luethi, Matthias E Liechti
Background: Pharmacological profiles of new psychoactive substances (NPSs) can be established rapidly in vitro and provide information on potential psychoactive effects in humans. The present study investigated whether specific in vitro monoamine transporter and receptor interactions can predict effective psychoactive doses in humans. Methods: We correlated previously assessed in vitro data of stimulants and psychedelics with human doses that are reported on the Internet and in books...
May 29, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29788422/n-acetyl-and-glutamatergic-neurometabolites-in-perisylvian-brain-regions-of-methamphetamine-users
#13
Jinsong Tang, Joseph O'Neill, Jeffry R Alger, Zhiwei Shen, Maritza C Johnson, Edythe D London
Background: Methamphetamine induces neuronal N-acetyl-aspartate synthesis in preclinical studies. In a preliminary human proton magnetic resonance spectroscopic imaging investigation, we also observed that N-acetyl-aspartate+N-acetyl-aspartyl-glutamate in right inferior frontal cortex correlated with years of heavy methamphetamine abuse. In the same brain region, glutamate+glutamine is lower in methamphetamine users than in controls and is negatively correlated with depression. N-acetyl and glutamatergic neurochemistries therefore merit further investigation in methamphetamine abuse and the associated mood symptoms...
May 21, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29788232/chronic-stress-exposure-reduces-parvalbumin-expression-in-the-rat-hippocampus-through-an-imbalance-of-redox-mechanisms-restorative-effect-of-the-antipsychotic-lurasidone
#14
Andrea C Rossetti, Maria Serena Paladini, Martina Colombo, Piotr Gruca, Magdalena Lason-Tyburkiewicz, Katarzyna Tota-Glowczyk, Mariusz Papp, Marco A Riva, Raffaella Molteni
Background: Psychiatric disorders are associated with altered function of inhibitory neurotransmission within the limbic system, which may be due to the vulnerability of selective neuronal subtypes to challenging environmental conditions, such as stress. In this context, parvalbumin (PVB) positive GABAergic interneurons, which are critically involved in processing complex cognitive tasks, are particularly vulnerable to stress exposure, an effect that may be the consequence of dysregulated redox mechanisms...
May 18, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29762677/anti-dementia-drugs-for-psychopathology-and-cognitive-impairment-in-schizophrenia-a-systematic-review-and-meta-analysis
#15
Taro Kishi, Toshikazu Ikuta, Kazuto Oya, Shinji Matsunaga, Yuki Matsuda, Nakao Iwata
Background: We conducted a systematic review and meta-analysis of double-blind, randomized, placebo-controlled trials of anti-dementia drugs plus antipsychotics (ADD+AP) for schizophrenia. Methods: Primary outcomes of efficacy and safety included improving overall symptoms (Positive and Negative Syndrome Scale and Brief Psychiatric Rating Scale scores) and all-cause discontinuation, respectively. Other outcomes included psychopathology subscales (positive, negative, general, and anxiety/depressive symptoms), cognitive function (attention/vigilance, reasoning/problem solving, social cognition, speed of processing, verbal learning, visual learning, working memory, and cognitive control/executive function), Mini-Mental State Examination (MMSE) scores, treatment discontinuation due to adverse events and inefficacy, and individual adverse events...
May 14, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29762664/behavioral-and-serotonergic-changes-in-the-frontal-cortex-following-methamphetamine-self-administration
#16
Lisa M McFadden, Rebecca Cordie, Tamee Livermont, Andrew Johansen
Background: Methamphetamine (METH) use is associated with a variety of negative health outcomes including psychosis. The frontal cortex serotonin (5-HT)-2 receptors are thought to contribute to psychosis-like behaviors. This study investigated changes in serotonergic markers in the frontal cortex following METH self-administration and hallucinogenic drug-induced behavior. Methods: Consistent with previously published studies, freely-cycling male and female rats were allowed to self-administer METH (Males: 0...
May 14, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29762671/motor-impairments-correlate-with-social-deficits-and-restricted-neuronal-loss-in-an-environmental-model-of-autism
#17
Tareq Al Sagheer, Obelia Haida, Anais Balbous, Maureen Francheteau, Emmanuel Matas, Pierre-Olivier Fernagut, Mohamed Jaber
Background: Motor impairments are amongst the earliest and most consistent signs of autism spectrum disorders (ASD) but are not used as diagnostic criteria. In addition, the relationship between motor and cognitive impairments and their respective neural substrates remain unknown. Methods: Here, we aimed at determining whether a well-acknowledged animal model of ASD, the valproic acid (VPA) model, displays motor impairments and whether they may correlate with social deficits and neuronal loss within motor brain areas...
May 12, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29746646/corticostriatal-connectivity-in-antisocial-personality-disorder-by-mao-a-genotype-and-its-relationship-to-aggressive-behavior
#18
Nathan J Kolla, Katharine Dunlop, Jeffrey H Meyer, Jonathan Downar
Background: The influence of genetic variation on resting-state neural networks represents a burgeoning line of inquiry in psychiatric research. Monoamine oxidase A, an X-linked gene, is one example of a molecular target linked to brain activity in psychiatric illness. Monoamine oxidase A genetic variants, including the high and low variable nucleotide tandem repeat polymorphisms, have been shown to differentially affect brain functional connectivity in healthy humans. However, it is currently unknown whether these same polymorphisms influence resting-state brain activity in clinical conditions...
May 9, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29718262/ketamine-effects-on-eeg-during-therapy-of-treatment-resistant-generalized-anxiety-and-social-anxiety
#19
Shabah Mohammad Shadli, Tame Kawe, Daniel Martin, Neil McNaughton, Shona Neehoff, Paul Glue
Background: Ketamine is swiftly effective in a range of neurotic disorders that are resistant to conventional antidepressant and anxiolytic drugs. The neural basis for its therapeutic action is unknown. Here we report the effects of ketamine on the EEG of patients with treatment-resistant generalized anxiety and social anxiety disorders. Methods: Twelve patients with refractory DSM-IV generalized anxiety disorder and/or social anxiety disorder provided EEG during 10 minutes of relaxation before and 2 hours after receiving double-blind drug administration...
April 24, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29688411/relevance-of-rodent-models-of-depression-in-clinical-practice-can-we-overcome-the-obstacles-in-translational-neuropsychiatry
#20
Johan Söderlund, Maria Lindskog
The diagnosis of a mental disorder generally depends on clinical observations and phenomenological symptoms reported by the patient. The definition of a given diagnosis is criteria based and relies on the ability to accurately interpret subjective symptoms and complex behavior. This type of diagnosis comprises a challenge to translate to reliable animal models, and these translational uncertainties hamper the development of new treatments. In this review, we will discuss how depressive-like behavior can be induced in rodents, and the relationship between these models and depression in humans...
April 23, 2018: International Journal of Neuropsychopharmacology
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