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International Journal of Neuropsychopharmacology

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https://www.readbyqxmd.com/read/29329382/adolescent-synthetic-cannabinoid-exposure-produces-enduring-changes-in-dopamine-neuron-activity-in-a-rodent-model-of-schizophrenia-susceptibility
#1
David D Aguilar, Andrea Giuffrida, Daniel J Lodge
Background: Epidemiological studies recognize cannabis intake as a risk factor for schizophrenia, yet the majority of adolescents who use marijuana do not develop psychosis. Similarly, the abuse of synthetic cannabinoids poses a risk for psychosis. For these reasons, it is imperative to understand the effects of adolescent cannabinoid exposure in susceptible individuals. Method: We have recently developed a novel rodent model of schizophrenia susceptibility, the F2 MAM rat, where only a proportion (~40%) of rats display a schizophrenia-like phenotype...
January 10, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29294032/is-metabolism-of-r-ketamine-essential-for-the-antidepressant-effects
#2
Shigeyuki Chaki
No abstract text is available yet for this article.
December 26, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29294029/estrogen-receptor-%C3%AE-in-the-nucleus-accumbens-regulates-the-rewarding-properties-of-cocaine-in-female-mice
#3
Rosalba Satta, Briana Certa, Donghong He, Amy W Lasek
Background: Females are more vulnerable to developing cocaine addiction compared with males, a phenomenon that may be regulated by the steroid hormone 17β-estradiol (E2). E2 enhances cocaine reward as measured by the conditioned place preference (CPP) test. It is currently not known which estrogen receptor is involved or the neuroanatomical locations in which estrogen receptors act to enhance cocaine responses. The purpose of this study was to determine if the estrogen receptors ERαand ERβ regulate cocaine CPP in mice and whether they act in the nucleus accumbens (Acb), a brain region critically involved in the development of cocaine abuse...
December 23, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29309585/role-of-5-ht1a-receptor-stimulation-in-the-medial-prefrontal-cortex-in-the-sustained-antidepressant-effects-of-ketamine
#4
Kenichi Fukumoto, Michihiko Iijima, Takeo Funakoshi, Shigeyuki Chaki
Background: We previously reported that serotonergic transmission plays an important role in antidepressant effects of ketamine. However, detailed mechanisms have not been elucidated. Among the serotonin (5-HT) receptor subtypes, the 5-HT1A receptor in the medial prefrontal cortex (mPFC) has an important role in depression. Here, we investigated the role of the mPFC 5-HT1A receptor and its signaling mechanism in the antidepressant effects of ketamine. Methods: The role of 5-HT1A receptor-mediated signaling mechanism (phosphoinositide-3 kinase (PI3K)/Akt) in the mPFC was examined in the mouse forced swimming test and western blotting...
December 22, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29272412/antagonism-of-neurotensin-receptors-in-the-ventral-tegmental-area-decreases-methamphetamine-self-administration-and-methamphetamine-seeking-in-mice
#5
Sergio Dominguez-Lopez, Elisabeth Piccart, William B Lynch, Mackenna B Wollet, Amanda L Sharpe, Michael J Beckstead
Background: Neurotensin is a peptide that modulates central dopamine neurotransmission and dopamine-related behaviors. Methamphetamine (METH) self-administration increases neurotensin levels in the ventral tegmental area (VTA), but the consequences for self-administration behavior have not been described. Here we test the hypothesis that antagonizing neurotensin receptors in the VTA attenuates the acquisition of METH self-administration and METH intake. Methods: We implanted mice with an indwelling catheter in the right jugular vein and bilateral cannulae directed at the VTA...
December 20, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29228215/mitochondria-are-critical-for-bdnf-mediated-synaptic-and-vascular-plasticity-of-hippocampus-following-repeated-electroconvulsive-seizures
#6
Fenghua Chen, Maryam Ardalan, Betina Elfving, Gregers Wegener, Torsten M Madsen, Jens R Nyengaard
Background: Electroconvulsive therapy (ECT) is a fast acting and efficient treatment of depression used in the clinic. The underlying mechanism of its therapeutic effect is still unclear. However, recovery of synaptic connections and synaptic remodeling is thought to play a critical role for the clinical efficacy obtained from a rapid antidepressant response. Here, we investigated the relationship between, synaptic changes and concomitant non-neuronal changes in microvasculature and mitochondria, and it relationship to Brain-derived neurotrophic factor (BDNF) level changes after repeated electroconvulsive seizures (ECS), an animal model of ECT...
December 8, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29228200/ect-has-greater-efficacy-than-fluoxetine-in-alleviating-the-burden-of-illness-for-patients-with-major-depressive-disorder-a-taiwanese-pooled-analysis
#7
Ching-Hua Lin, Chun-Jen Huang, Cheng-Chung Chen
Background: The burden of major depressive disorder (MDD) includes suffering due to symptom severity, functional impairment, and quality of life (QOL) deficits. The aim of this study was to compare the differences between ECT and pharmacotherapy in reducing such burdens. Methods: This was a pooled analysis study including two open-label trials for MDD inpatients receiving either standard bitemporal and modified ECT with a maximum of 12 sessions, or 20 mg/d of fluoxetine for 6 weeks...
December 8, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29228174/cardiovascular-risk-in-early-psychosis-relationship-with-inflammation-and-clinical-features-6-months-after-diagnosis
#8
Molero M F Barcones, K S MacDowell, B García Bueno, M Bioque, L Gutiérrez-Galve, A González Pinto, M J Parellada, J Bobes, M Bernardo, A Lobo, J C Leza
Background: We aimed to investigate the state of cardiovascular risk/protection factors in early psychosis patients. Methods: 119 subjects were recruited during the first year after their first episode of psychosis (FEP). 85 of these subjects were followed during the next 6 months. Cardiovascular risk/protection factors were measured in plasma and co-variated by sociodemographic/clinical characteristics. Multiple linear regression models detected the change of each biological marker from baseline to follow-up in relation to clinical scales, antipsychotic medication and pro/anti-inflammatory mediators...
December 8, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29216351/1-adrenoceptor-in-the-central-amygdala-is-required-for-unconditioned-stimulus-induced-drug-memory-reconsolidation
#9
Huiwen Zhu, Yiming Zhou, Zhiyuan Liu, Xi Chen, Yanqing Li, Xing Liu, Lan Ma
Background: Drug memories become labile and reconsolidated after retrieval by presentation of environmental cues (conditioned stimulus, CS) or drugs (unconditioned stimulus, US). Whether CS- and US-retrieval trigger different memory reconsolidation processes is not clear. Methods: Protein synthesis inhibitor or β-AR antagonist was systemically administrated or intra-central amygdala (CeA) infused immediately after cocaine re-exposure in cocaine-conditioned place preference (CPP) or self-administration (SA) mice models...
December 5, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29206921/acute-effects-of-methylphenidate-modafinil-and-mdma-on-negative-emotion-processing
#10
André Schmidt, Felix Müller, Patrick C Dolder, Yasmin Schmid, Davide Zanchi, Laura Egloff, Matthias E Liechti, Stefan Borgwardt
Background: Stimulants such as methylphenidate (MPH) and modafinil are frequently used as cognitive enhancers in healthy people, whereas 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) is proposed to enhance mood and empathy in healthy subjects. However, comparative data on the effects of MPH and modafinil on negative emotions in healthy subjects have been widely missing. The aim of this study was to compare the acute effects of MPH and modafinil on the neural correlates of fearful face processing using MDMA as a positive control...
December 1, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29186431/monoamine-oxidase-a-gene-methylation-and-its-role-in-posttraumatic-stress-disorder-first-evidence-from-the-south-eastern-europe-see-ptsd-study
#11
Christiane Ziegler, Christiane Wolf, Miriam A Schiele, Elma Feric Bojic, Sabina Kucukalic, Emina Sabic Dzananovic, Aferdita Goci Uka, Blerina Hoxha, Valdete Haxhibeqiri, Shpend Haxhibeqiri, Nermina Kravic, Mirnesa Muminovic Umihanic, Ana Cima Franc, Nenad Jaksic, Romana Babic, Marko Pavlovic, Bodo Warrings, Alma Bravo Mehmedbasic, Dusko Rudan, Branka Aukst-Margetic, Abdulah Kucukalic, Damir Marjanovic, Dragan Babic, Nada Bozina, Miro Jakovljevic, Osman Sinanovic, Esmina Avdibegovic, Ferid Agani, Alma Dzubur-Kulenovic, Jürgen Deckert, Katharina Domschke
Background: Posttraumatic Stress Disorder (PTSD) is characterized by an overactive noradrenergic system conferring core PTSD symptoms such as hyperarousal and re-experiencing. Monoamine oxidase A (MAO-A) is one of the key enzymes mediating the turnover of noradrenaline. Here, DNA methylation of the MAOA gene exonI/intronI region was investigated for the first time in regards to its role in PTSD risk and severity. Methods: MAOA methylation was analyzed via direct sequencing of sodium bisulfite treated DNA extracted from blood cells in a total sample of N=652 (m=441) patients with current PTSD, patients with remitted PTSD and healthy probands (comparison group) recruited at five centres in Bosnia-Herzegovina, Croatia, and the Republic of Kosovo...
November 23, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29186416/a-randomized-dose-ranging-study-of-neuropeptide-y-in-patients-with-posttraumatic-stress-disorder
#12
Sehrish Sayed, Nicholas T Van Dam, Sarah R Horn, Marin M Kautz, Michael Parides, Sara Costi, Katherine A Collins, Brian Iacoviello, Dan V Iosifescu, Aleksander A Mathé, Steven M Southwick, Adriana Feder, Dennis S Charney, James W Murrough
Background: Anxiety and trauma-related disorders are among the most prevalent and disabling medical conditions in the U.S., and posttraumatic stress disorder (PTSD) in particular exacts a tremendous public health toll. We examined the tolerability and anxiolytic efficacy of neuropeptide Y (NPY) administered via an intranasal route in patients with PTSD. Methods: Twenty-six individuals were randomized in a cross-over, single ascending dose study into one of five cohorts: 1...
November 23, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29182724/worsening-anxiety-irritability-insomnia-or-panic-predicts-poorer-antidepressant-treatment-outcomes-clinical-utility-and-validation-of-the-concise-associated-symptom-tracking-cast-scale
#13
Manish K Jha, Abu Minhajuddin, Charles South, A John Rush, Madhukar H Trivedi
Background: We report on the psychometric properties of the 16-item Concise Associated Symptom Tracking Scale (CAST) self-report scale and its clinical utility. Methods: The five-domain (irritability, anxiety, mania, insomnia, and panic) structure of CAST was validated with confirmatory factor analysis (CFA) in Combining Medications to Enhance Depression Outcomes trial participants at baseline (n=664). Correlations with other clinical measures was used for convergent and divergent validity...
November 22, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29182715/modulation-of-rat-50-khz-ultrasonic-vocalizations-by-glucocorticoid-signaling-possible-relevance-to-reward-and-motivation
#14
Nicola Simola, Elena Paci, Marcello Serra, Giulia Costa, Micaela Morelli
Background: Rats emit 50-kHz ultrasonic vocalizations (USVs) to communicate positive emotional states, and these USVs are increasingly being investigated in preclinical studies on reward and motivation. Although it is the activation of dopamine receptors that initiates the emission of 50-kHz USVs, non-dopaminergic mechanisms may modulate calling in the 50 kHz frequency band. To further elucidate these mechanisms, the present study investigated whether the pharmacological manipulation of glucocorticoid signaling influenced calling...
November 22, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29165617/selective-activation-of-striatal-ngf-trka-p75ntr-mapk-intracellular-signaling-in-rats-that-show-suppression-of-methamphetamine-intake-30-days-following-drug-abstinence
#15
Oscar V Torres, Subramanian Jayanthi, Michael T McCoy, Jean Lud Cadet
Background: The continuing epidemic of methamphetamine (METH) addiction has prompted research aimed at understanding striatal dysfunctions potentially associated with long-term METH use. Methods: Here, we investigated transcriptional and translational alterations in the expression of neurotrophic factors in the rat striatum at 30 days following METH SA and footshock punishment. Male Sprague-Dawley rats were trained to self-administer METH (0.1 mg/kg/injection, i...
November 20, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29165565/cued-reinstatement-of-cocaine-but-not-sucrose-seeking-is-dependent-upon-dopamine-signaling-in-prelimbic-cortex-and-is-associated-with-recruitment-of-prelimbic-neurons-that-project-to-contralateral-nucleus-accumbens-core
#16
Morgan H James, Ellen M McGlinchey, Asrita Vattikonda, Stephen V Mahler, Gary Aston-Jones
Background: Drug cues recruit prelimbic cortex (PL) neurons that project to ipsilateral nucleus accumbens core (NAcCipsi). However, it is not known if the same is true for PL projections that decussate to innervate contralateral NAcC (NAcCcontra). Further, a role for PL dopamine signaling in cued reinstatement of cocaine seeking has not been shown. Methods: We assessed Fos expression in PL neurons that project to NAcCcontra following cued reinstatement of cocaine or sucrose seeking...
November 20, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29155989/5-hydroxytryptamine-independent-antidepressant-actions-of-r-ketamine-in-a-chronic-social-defeat-stress-model
#17
Kai Zhang, Chao Dong, Yuko Fujita, Atsuhiro Fujita, Kenji Hashimoto
Background: Previous reports suggest that 5-hydroxytryptamine (5-HT) might play a role in the antidepressant actions of (R,S)-ketamine. However, its role in the antidepressant actions of (R)-ketamine, which is more potent than (S)-ketamine, is unknown. This study was conducted to examine whether 5-HT depletion affects the antidepressant actions of (R)-ketamine in a chronic social defeat stress (CSDS) model. Methods: An inhibitor of 5-HT synthesis, para-chlorophenylalanine methyl ester hydrochloride (PCPA; 300 mg/kg, twice daily for 3 consecutive days), or vehicle was administered to control and CSDS susceptible mice...
November 16, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29155993/lack-of-antidepressant-effects-of-2r-6r-hydroxynorketamine-in-a-rat-learned-helplessness-model-comparison-with-r-ketamine
#18
Yukihiko Shirayama, Kenji Hashimoto
Background: (R)-Ketamine exhibits rapid and sustained antidepressant effects in animal models of depression. It is stereoselectively metabolized to (R)-norketamine, and subsequently to (2R,6R)-hydroxynorketamine (HNK) in the liver. The metabolism of ketamine to HNK was recently demonstrated to be essential for ketamine's antidepressant actions. However, no study has compared the antidepressant effects of these three compounds in animal models of depression. Methods: The effects of a single intraperitoneal injection of (R)-ketamine, (R)-norketamine, and (2R,6R)-HNK in a rat learned helplessness (LH) model were examined...
November 15, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29228204/decreased-resting-state-interhemispheric-functional-connectivity-correlated-with-neurocognitive-deficits-in-drug-naive-first-episode-adolescent-onset-schizophrenia
#19
Yi Liu, Yan Zhang, Luxian Lv, Feihu Hu, Renrong Wu, Jingping Zhao, Wenbin Guo
Background: Given that adolescence is a critical epoch in the onset of schizophrenia, studying aberrant brain changes in adolescent-onset schizophrenia (AOS), particularly in patients with drug-naive first-episode schizophrenia, is important to understand the biological mechanism of this disorder. Previous resting-state functional magnetic resonance imaging (fMRI) studies have shown abnormal functional connectivity in separate hemispheres in patients with adult-onset schizophrenia. Our aim to study AOS can provide clues for the early aetiology of schizophrenia...
November 7, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29126171/copy-number-variant-in-the-region-of-adenosine-kinase-adk-and-its-possible-contribution-to-schizophrenia-susceptibility
#20
Hiroki Kimura, Itaru Kushima, Akira Yohimi, Branko Aleksic, Norio Ozaki
Background: Adenosine kinase (ADK) is supposed to be a schizophrenia (SCZ) susceptibility gene based on the findings that ADK is an enzyme that catalyzes transfer of the gamma-phosphate from ATP to adenosine, which interacts with dopamine and glutamate, neurotransmitters. However, no reports of SCZ cases with loss of function variants in the ADK region have been published. In our previous study investigating copy number variants (CNV) in SCZ, we detected a CNV in the ADK region in one of 1699 SCZ patients...
November 6, 2017: International Journal of Neuropsychopharmacology
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