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International Journal of Neuropsychopharmacology

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https://www.readbyqxmd.com/read/28430976/acute-and-chronic-noradrenergic-effects-on-cortical-excitability-in-healthy-humans
#1
Hsiao-I Kuo, Walter Paulus, Giorgi Batsikadze, Asif Jamil, Min-Fang Kuo, Michael A Nitsche
Background: Noradrenaline is a major neuromodulator in the central nervous system, and it is involved in the pathophysiology of diverse neuropsychiatric diseases. Previous transcranial magnetic stimulation (TMS) studies suggested that acute application of selective noradrenaline reuptake inhibitors (NRI) enhances cortical excitability in the human brain. However, other, such like clinical effects, usually require prolonged NRI treatment, which might go along with different physiological effects...
April 19, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28430980/the-relationship-between-symptom-relief-and-psychosocial-functional-improvement-during-acute-electroconvulsive-therapy-for-patients-with-major-depressive-disorder
#2
Ching-Hua Lin, Wei-Cheng Yang
Background: We aimed to compare the degree of symptom relief to psychosocial functional (abbreviated as "functional") improvement and explore the relationships between symptom relief and functional improvement during acute electroconvulsive therapy (ECT) for patients with major depressive disorder (MDD). Methods: MDD inpatients (N=130) requiring ECT were recruited. ECT was generally performed for a maximum of 12 treatments. Symptom severity, using the 17-item Hamilton Depression Rating Scale (HAMD-17), and psychosocial functioning (abbreviated as "functioning"), using the Modified Work and Social Adjustment Scale (MWSAS), were assessed before ECT, after every 3 ECT treatments, and after the final ECT...
April 18, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28430979/effect-of-physical-exercise-and-acute-escitalopram-on-the-excitability-of-brain-monoamine-neurons-in-vivo-electrophysiological-study-in-rats
#3
Eliyahu Dremencov, Kristína Csatlósová, Barbora Durišová, Lucia Lapínová, Lubica Lacinová, Daniela Ježová
Background: The antidepressant effect of physical exercise has been reported in several clinical and animal studies. Since serotonin (5-HT), norepinephrine and dopamine play a central role in depression, it is possible that the beneficial effects of physical exercise are mediated via monoamine pathways. This study investigates the effects of voluntary wheel running (VWR) on the excitability of monoamine neurons. Material and methods: Male Sprague-Dawley rats were used in the study...
April 18, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28419244/resolvin-d1-and-d2-reverse-lipopolysaccharide-induced-depression-like-behaviors-through-the-mtorc1-signaling-pathway
#4
Satoshi Deyama, Yuka Ishikawa, Kotomi Yoshikawa, Kento Shimoda, Soichiro Ide, Masamichi Satoh, Masabumi Minami
Background: Resolvin D1 (RvD1) and D2 (RvD2) are bioactive lipid mediators that are generated from docosahexaenoic acid (DHA). Although recent preclinical studies suggest that these compounds have antidepressant effects, their mechanisms of action remain unclear. Methods: We investigated mechanisms underlying the antidepressant effects of RvD1 and RvD2 in lipopolysaccharide (LPS; 0.8 mg/kg, i.p.)-induced depression model mice using a tail suspension test. Results: Intracerebroventricular (i...
April 13, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28371917/our-explain-to-three-doubts
#5
Yoshio Yamanouchi, Tsuruhei Sukegawa, Ataru Inagaki, Toshiya Inada, Takashi Yoshio, Reiji Yoshimura, Nakao Iwata
No abstract text is available yet for this article.
March 29, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28340122/potential-role-of-patients-cyp3a-status-in-clozapine-pharmacokinetics
#6
Katalin Tóth, Gábor Csukly, Dávid Sirok, Ales Belic, Ádám Kiss, Edit Háfra, Máté Déri, Ádám Menus, István Bitter, Katalin Monostory
Background: The atypical antipsychotic clozapine is effective in treatment-resistant schizophrenia; however, the success or failure of clozapine therapy is substantially affected by the variables that impact the clozapine blood concentration. Thus, elucidating the inter-individual differences in clozapine pharmacokinetics can facilitate the personalized therapy. Methods: Since potential role in clozapine metabolism is assigned to CYP1A2, CYP2C19, CYP2D6 and CYP3A enzymes, the association between the patients' CYP-status (CYP genotypes, CYP expression) and clozapine clearance was evaluated in 92 psychiatric patients...
March 18, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28340169/histamine-receptors-in-the-cross-talk-between-periphery-and-brain
#7
Maria Lindskog
No abstract text is available yet for this article.
March 15, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28340244/bupropion-administration-increases-resting-state-functional-connectivity-in-dorso-medial-prefrontal-cortex
#8
Ewelina Rzepa, Zola Dean, Ciara McCabe
Background: Patients on the selective serotonergic re-uptake inhibitors (SSRI) like citalopram report emotional blunting. We have shown previously that citalopram reduces resting-state functional connectivity (RSFC) in healthy volunteers in a number of brain regions including the dorso-medial prefrontal cortex, which may be related to its clinical effects. Bupropion is a dopaminergic and noradrenergic re-uptake inhibitor (DNRI) and is not reported to cause emotional blunting. However how bupropion affects RSFC in healthy controls remains unknown...
March 11, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28339814/modulating-oxidative-stress-relieves-stress-induced-behavioral-and-cognitive-impairments-in-rats
#9
Naimesh Solanki, Ankita Salvi, Gaurav Patki, Samina Salim
Background: Persistent psychological stress often leads to anxiety disorders and depression. Benzodiazepines and selective serotonin reuptake inhibitors are popular treatment options but have limited efficacy, supporting the need for alternative treatment. Based on our recent preclinical work suggesting a causal link between neurobehavioral deficits and elevated oxidative stress, we hypothesized that interventions that mitigate oxidative stress can attenuate/overcome neurobehavioral deficits...
February 24, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28339795/erratum
#10
(no author information available yet)
No abstract text is available yet for this article.
February 24, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28339691/z-guggulsterone-produces-antidepressant-like-effects-in-mice-through-activation-of-the-bdnf-signaling-pathway
#11
Chao Huang, Wen-Feng Hu, Ji-Li Wang, Peng Wang, Yu Gong, Li-Juan Tong, Bo Jiang, Wei Zhang, Yi-Bin Qin, Zhuo Chen, Rong-Rong Yang
Background: Z-guggulsterone, an active compound extracted from the gum resin of the tree commiphora mukul, has been shown to improve animal memory deficits via activating the brain-derived neurotrophic factor (BDNF) signaling pathway. Here, we investigated the antidepressant-like effect of Z-guggulsterone in a chronic unpredictable stress (CUS) mouse model of depression. Methods: The effects of Z-guggulsterone were assessed in mice tail suspension test (TST), forced swimming test (FST)...
February 21, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28204607/aripiprazole-once-monthly-400-mg-comparison-of-pharmacokinetics-tolerability-and-safety-of-deltoid-versus-gluteal-administration
#12
Arash Raoufinia, Timothy Peters-Strickland, Anna-Greta Nylander, Ross A Baker, Anna Eramo, Na Jin, Patricia Bricmont, Jennifer Repella, Robert D McQuade, Peter Hertel, Frank Larsen
No abstract text is available yet for this article.
February 15, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28204487/cry-baby-cry-expression-of-distress-as-a-biomarker-and-modulator-in-autism-spectrum-disorder
#13
Gianluca Esposito, Noboru Hiroi, Maria Luisa Scattoni
No abstract text is available yet for this article.
February 15, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28201726/discontinuation-efficacy-and-safety-of-cholinesterase-inhibitors-for-alzheimer-s-disease-a-meta-analysis-and-meta-regression-of-44-randomized-clinical-trials-enrolling-16-245-patients
#14
Lídia Blanco-Silvente, Xavier Castells, Marc Saez, Maria Antònia Barceló, Josep Garre-Olmo, Joan Vilalta-Franch, Dolors Capellà
No abstract text is available yet for this article.
February 13, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28199677/use-of-a-spin-strategy-can-result-in-unreliable-research-findings
#15
Yasuyuki Okumura
No abstract text is available yet for this article.
February 11, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28199666/the-role-of-dopamine-d1-and-d3-receptors-in-n-methyl-d-aspartate-nmda-glycineb-site-regulated-complex-cognitive-behaviors-following-repeated-morphine-administration
#16
Yunpeng Wang, Fangyuan Yin, Hao Guo, Jing Zhang, Peng Yan, Jianghua Lai
No abstract text is available yet for this article.
February 11, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28177082/5-ht2a-agonists-a-novel-therapy-for-functional-neurological-disorders
#17
Alexander Bryson, Olivia Carter, Trevor Norman, Richard Kanaan
No abstract text is available yet for this article.
February 8, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28177081/the-working-memory-and-dorsolateral-prefrontal-hippocampal-functional-connectivity-changes-in-long-term-survival-breast-cancer-patients-treated-with-tamoxifen
#18
Xingui Chen, Xiaoxuan He, Longxiang Tao, Jingjing Li, Jiaonan Wu, Chunyan Zhu, Fengqiong Yu, Lei Zhang, Jingjie Zhang, Bensheng Qiu, Yongqiang Yu, Kai Wang
No abstract text is available yet for this article.
February 8, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28165131/structural-integrity-in-the-sustained-antidepressant-effect-of-ketamine
#19
Pauline Belujon
No abstract text is available yet for this article.
February 6, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28165117/decreased-nucleus-accumbens-expression-of-psychiatric-disorder-risk-gene-cacna1c-promotes-susceptibility-to-social-stress
#20
Chantelle E Terrillion, T Chase Francis, Adam C Puche, Mary Kay Lobo, Todd D Gould
No abstract text is available yet for this article.
February 6, 2017: International Journal of Neuropsychopharmacology
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