Hamad Ali, Md Zubbair Malik, Mohamed Abu-Farha, Jehad Abubaker, Preethi Cherian, Rasheeba Nizam, Sindhu Jacob, Yousif Bahbahani, Medhat Naim, Sajjad Ahmad, Mohammad Al-Sayegh, Thangavel Alphonse Thanaraj, Albert C M Ong, Peter C Harris, Fahd Al-Mulla
BACKGROUND: Autosomal dominant polycystic kidney disease (ADPKD) is the most prevalent monogenic renal disease progressing to end-stage renal disease. There is a pressing need for the identification of early ADPKD biomarkers to enable timely intervention and the development of effective therapeutic approaches. Here, we profiled human urinary extracellular vesicles small RNAs by small RNA sequencing in patients with ADPKD and compared their differential expression considering healthy control individuals to identify dysregulated small RNAs and analyze downstream interaction to gain insight about molecular pathophysiology...
February 2024: Journal of Gene Medicine