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Journal of Gene Medicine

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https://www.readbyqxmd.com/read/29323771/association-of-igfn1-variant-with-polypoidal-choroidal-vasculopathy
#1
Xiaofeng Wen, Yu Liu, Qi Yan, Minling Liang, Miao Tang, Ran Liu, Jianying Pan, Qiuhui Liu, Tingting Chen, Shixin Guo, Juanran Liang, Lin Lu, Xiaoyan Ding, Wei Chen, Lai Wei
BACKGROUND: Polypoidal choroidal vasculopathy (PCV) and neovascular age-related macular degeneration (nAMD) share similar phenotype but are different in clinical manifestations, responses to treatment, and prognosis. Whether PCV is a subtype of AMD or a distinct entity from nAMD remains elusive. Therefore, we performed a whole-exome sequencing (WES) based association analysis to compare the genetic architecture of PCV and nAMD in Han Chinese. METHODS: Whole-exome sequencing analysis was performed on 21 nAMD cases, 20 PCV cases and 20 healthy controls...
January 11, 2018: Journal of Gene Medicine
https://www.readbyqxmd.com/read/29314442/lncrna-cdkn2bas-rs2157719-genetic-variant-contributes-to-medulloblastoma-predisposition
#2
Yi-Dong Chen, Nasha Zhang, Xiao-Guang Qiu, Jupeng Yuan, Ming Yang
BACKGROUND: How germline single nucleotide polymorphisms are involved in the etiology of medulloblastoma remans poorly understood. We hypothesized that CCDKN2A/B rs1063192 and rs4977756 and also the long noncoding RNA (lncRNA) CDKN2BAS rs2157719 glioma susceptibility polymorphisms identified by genome-wide association studies may contribute to medulloblastoma predisposition. METHODS: To test this hypothesis, we genotyped these genetic variants among 160 medulloblastoma patients and 443 health controls in a Chinese population...
January 4, 2018: Journal of Gene Medicine
https://www.readbyqxmd.com/read/29282802/impact-of-cellular-restriction-gene-trim5%C3%AE-bst-2-polymorphisms-on-the-acquisition-of-hiv-1-and-disease-progression
#3
HariOm Singh, Dharmesh Samani, Manisha V Ghate, R R Gangakhedkar
BACKGROUND: TRIM5α and BST-2 are cellular restriction factors, affecting the HIV-1 infection and its progression. Genetic variability in these genes alters the expression pattern. Hence, we aimed to examine the impact of TRIM5α (rs10838525, rs7127617, and rs904375) and BST2 (rs3217318 and rs71694748) polymorphisms on the acquisition of HIV-1 and its progression. METHOD: Genotyping of TRIM5α and BST-2 polymorphisms performed in a total of 153 HIV-infected patients and 158 unrelated healthy individuals by PCR-RFLP method...
December 28, 2017: Journal of Gene Medicine
https://www.readbyqxmd.com/read/29243283/intra-articular-injection-of-autologous-adipose-derived-mesenchymal-stem-cells-in-treatment-of-knee-osteoarthritis
#4
Duško Spasovski, Vesna Spasovski, Zoran Baščarević, Maja Stojiljković, Miša Vreća, Marina Andjelković, Sonja Pavlović
BACKGROUND: Osteoarthritis (OA) is a chronic degenerative joint disease, considered to be the fourth leading cause of disability and the second cause of inability to work in men. Recently, adipose derived mesenchymal stem cells (AD-MSCs) came in focus of regenerative medicine as promising tool for treatment of OA. It has been shown that administration of stem cells into impaired joints results in pain relief and improves quality of life, accompanied with restoration of hyaline articular cartilage...
December 15, 2017: Journal of Gene Medicine
https://www.readbyqxmd.com/read/29218813/association-of-pnpla3-rs738409-polymorphism-with-liver-steatosis-but-not-with-cirrhosis-in-patients-with-hbv-infection-systematic-review-with-meta-analysis
#5
REVIEW
Saman Ghalamkari, Heidar Sharafi, Seyed Moayed Alavian
BACKGROUND AND AIM: Hepatitis B virus (HBV) infection is a worldwide health issue and is well known to be the main cause of developing secondary liver complications such as cirrhosis and hepatocellular carcinoma (HCC). The PNPLA3 rs738409 polymorphism has been investigated conclusively with occurrence risk of steatosis and cirrhosis. Therefore, performing a meta-analysis of the available studies with the aim of clarifying the association between rs738409 and occurrence risk of steatosis and cirrhosis among HBV-infected patients would be helpful...
December 7, 2017: Journal of Gene Medicine
https://www.readbyqxmd.com/read/29165854/mmp-3-1171-5a-6a-lys45glu-variants-affect-serum-levels-of-matrix-metalloproteinase-mmp-3-and-correlate-with-severity-of-copd-a-study-of-mmp-3-mmp-7-and-mmp-12-in-a-tunisian-population
#6
Sarra Bchir, Hela Ben Nasr, Abdelhamid Garrouch, Amel Ben Anes, Ammar Abbassi, Zouhair Tabka, Karim Chahed
OBJECTIVE: The goal of this study was to examine the role of MMP-3 (-1171 5A/6A; Lys45Glu (A/G)), MMP-7 (-181) A/G and MMP-12 (-82 A/G; Asn357Ser (A/G)) variants in the development and severity of chronic obstructive pulmonary disease (COPD) in Tunisians. METHODS: Plethysmography was performed in all participants to measure FEV1, FVC and FEV1/FVC parameters. Genotyping of MMP-3, MMP-7 and MMP-12 polymorphisms was carried out in 138 patients with COPD and 216 healthy controls using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP)...
November 22, 2017: Journal of Gene Medicine
https://www.readbyqxmd.com/read/29106062/co-delivery-of-hif-1%C3%AE-sirna-and-5-fluorouracil-to-overcome-drug-resistance-in-gastric-cancer-sgc-7901-cells
#7
Yunna Chen, Li Sun, Dongdong Guo, Ziteng Wu, Weidong Chen
BACKGROUND: Drug resistance cancer cells have become a major problem in chemotherapy. To solve this problem co-delivery of siRNA and 5-fluorouracil chitosan nanoparticles were prepared to reverse the multidrug resistance of gastric cancer SGC-7901 cells in vitro. METHODS: Chitosan nanoparticles were prepared by ionic gel method. siRNA nanoparticles were characterized by gel retardation assays, particle size and zeta potential were measured to confirm nanoparticles formation...
November 6, 2017: Journal of Gene Medicine
https://www.readbyqxmd.com/read/29076194/genetic-factors-are-stressed-variably-by-onset-age-based-sample-selection-in-psoriasis-a-hint-from-mhc-region-based-analysis
#8
Lei Ye, Chao Yang, Jin-Fa Dou, Lei-Lei Wen, Wen-Jun Wang, Xiao-Dong Zheng, Xian-Bo Zuo, Fu-Sheng Zhou, Xing Fan, Xue-Jun Zhang
BACKGROUND: Large cohort-based genetic association studies have been established over a decade. However for certain disease, different results in GWAS level were concluded among studies, even in the same ethnics. We hypothesized onset-age based sample variables might have great impacts on the results. METHODS: In this study, we divided psoriasis patients into several subgroups according to the onset age bracket. We conducted genetic association analysis in MHC region of each patient subgroup with shared control subjects...
October 26, 2017: Journal of Gene Medicine
https://www.readbyqxmd.com/read/29059509/gene-therapy-for-neuropathic-pain-induced-by-spared-nerve-injury-with-naked-plasmid-encoding-hepatocyte-growth-factor
#9
Hu Chunsheng, Lu Yuxin, Cheng Xiaochen, Cui Yufang, Wu Zuze, Zhang Qinglin
BACKGROUND: Neuropathic pain (NP) is a refractory disease in clinic and tremendously impacts on the patients' quality of life. Gene therapy is a potential strategy for the management of NP. In this paper, we examined the analgesic effect and mechanism of hepatocyte growth factor (HGF) in vitro and in vivo. METHODS: We examined the proinflammatroy gene changes in lipopolysaccharide (LPS)-induced BV2 cells with quantitative real-time polymerase chain reaction (qRT-PCR) of interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α, and inducible nitric oxide synthase (iNOS)...
October 23, 2017: Journal of Gene Medicine
https://www.readbyqxmd.com/read/29047186/il-1rn-gene-polymorphisms-were-associated-with-breast-cancer-risk-in-a-chinese-han-population
#10
Tianbo Jin, Wei Cao, Xiaoxiao Zuo, Miao Li, Ya Yang, Tiansong Liang, Hongyao Yang, Xinhan Zhao, Daoke Yang
BACKGROUND: Interleukin (IL) is a large family of endogenous cytokine which are crucial in the regulation of inflammation and immunological responses. IL-1 receptor antagonist (IL-1RN) has been found to be associated with risk breast cancer (BC) in Korean and Indian women. However, little information is found about the polymorphisms of IL-1RN in Chinese Han BC patient. METHODS: We investigated the association between single-nucleotide polymorphisms (SNPs) in IL-1RN and BC risk in a case-control study that included 530 BC cases and 628 healthy controls...
October 18, 2017: Journal of Gene Medicine
https://www.readbyqxmd.com/read/29044877/sustained-fxn-expression-in-dorsal-root-ganglia-from-a-nonreplicative-genomic-hsv-1-vector
#11
Maria Ventosa, Zetang Wu, Filip Lim
BACKGROUND: Friedreich's ataxia (FA) is an autosomal recessive neurodegenerative disease caused by mutations in the frataxin gene (FXN), which lead to reduced levels of the essential mitochondrial protein frataxin. Currently there is no effective cure. METHODS: With the aim of developing a gene therapy for FA neuropathology, here we describe the construction and preliminary characterization of a high capacity nonreplicative genomic herpes simplex virus type 1 vector (H24B-FXNlac vector) carrying a reduced version of the human FXN genomic locus, comprising the 5 kb promoter and the FXN cDNA with the inclusion of intron 1...
October 17, 2017: Journal of Gene Medicine
https://www.readbyqxmd.com/read/29044850/mesenchymal-stem-cells-therapy-a-promising-cell-based-therapy-for-treatment-of-myocardial-infraction
#12
REVIEW
Ayman El Sayed Shafei, Mahmoud Ahmed Ali, Hazem G Ghanem, Ahmed I Shehata, Ahmed A Abdelgawad, Hossam R Handal, Kareem A Talaat, Ahmed E Ashaal, Amal S El-Shal
AIM: For decades, mesenchymal stem (MSCs) cells had been used for cardiovascular diseases as regenerative therapy. This review is an attempt to summarize the types of MSCs involved in MI therapy, its possible mechanisms effects especially paracrine one in MI focusing on the studies (human and animal) conducted in the last 10 years. DISCUSSION: Recently, reports showed that MSC therapy could have infarct-limiting effects after myocardial infarction (MI) in both experimental and clinical trials...
October 16, 2017: Journal of Gene Medicine
https://www.readbyqxmd.com/read/29024250/non-invasive-detection-of-bladder-cancer-via-expression-targeted-gene-delivery
#13
Yunlan Fang, B Wolfson, W T Godbey
BACKGROUND: Because of the time and expense associated with the procedures and possible distress to the patient, cystoscopy or other imaging techniques are typically not used for bladder cancer detection before symptoms become present. Alternatively, commercial assays for urinary tumor markers exist but are marred by low sensitivity and high cost. There is a need for a simple and sensitive means of tumor detection, such as via the analysis of urine. METHODS: Plasmids encoding the secretable reporter Gaussia luciferase (G...
October 11, 2017: Journal of Gene Medicine
https://www.readbyqxmd.com/read/28990350/association-of-dnmt3b-gene-variants-with-sporadic-parkinson-s-disease-in-a-chinese-han-population
#14
Xiang Chen, Yousheng Xiao, Lei Wei, Yijuan Wu, Jianjun Lu, Wenyuan Guo, Shuxuan Huang, Miaomiao Zhou, Mingshu Mo, Zhe Li, Luan Cen, Shaomin Li, ChaohaoYang, Zhuohua Wu, Sophie Hu, Zhong Pei, XinLing Yang, Shaogang Qu, Pingyi Xu
INTRODUCTION: Parkinson's disease (PD) is the second most common neurodegenerative disorder worldwide. Epigenetic modifications, specifically DNA methylation, have been implicated in the development of this disease. Genetic variants of DNA methyltransferase 3b (DNMT3b), one of the most important DNA methyltransferases, were shown to be associated with PD in a Brazilian population. However, it is unclear whether genetic variants of DNMT3b increase the risk of PD in the Chinese Han people...
October 9, 2017: Journal of Gene Medicine
https://www.readbyqxmd.com/read/28990296/association-between-mthfr-microrna-binding-site-polymorphisms-and-methotrexate-concentrations-in-chinese-pediatric-patients-with-acute-lymphoblastic-leukemia
#15
Shu-Mei Wang, Wei-Xin Zeng, Wan-Shui Wu, Lu-Lu Sun, Dan Yan
BACKGROUND: The pharmacokinetics and therapeutic response to methotrexate (MTX) display large variability in the treatment of acute lymphoblastic leukemia (ALL). The aim of the present study was to investigate the association of two microRNA (miRNA) binding site polymorphisms (rs3737966 G > A and rs35134728 DEL/TTC) in the 3'UTR of MTHFR with serum MTX concentrations, in a Chinese pediatric population with ALL. METHODS: Genotyping for MTHFR rs3737966 and rs35134728 in 144 children with ALL was performed using the Sequenom MassArray system...
October 9, 2017: Journal of Gene Medicine
https://www.readbyqxmd.com/read/28985021/the-effects-of-gene-polymorphisms-on-glioma-prognosis
#16
Ying Cui, Guolin Li, Mengdan Yan, Jing Li, Tianbo Jin, Shanqu Li, Shijie Mu
PURPOSE: Malignant gliomas are the most common primary brain tumors. Various genetic factors play important roles in the development and prognosis of glioma. This study focuses on the impact of MPHOSPH6, TNIP1, and several other genes (ACYP2, NAF1, TERC, TERT, OBFC1, ZNF208, and RTEL1) on telomere length and how that affects the prognosis of glioma. MATERIALS AND METHODS: Forty-three polymorphisms in nine genes from 605 glioma patients were selected. The association between genotype and survival outcome was analyzed using the Kaplan-Meier method, Cox regression analysis, and the log-rank test...
October 6, 2017: Journal of Gene Medicine
https://www.readbyqxmd.com/read/29076590/erratum-posterior-tibial-tendinopathy-associated-with-matrix-metalloproteinase-13-promoter-genotype-and-haplotype
#17
(no author information available yet)
No abstract text is available yet for this article.
September 2017: Journal of Gene Medicine
https://www.readbyqxmd.com/read/28940887/association-of-human-leukocyte-antigen-polymorphisms-with-occult-hepatitis-b-virus-infection-in-a-shaanxi-han-population
#18
Tianju Wang, Chunmei Shen, Liping Chen, Sheng Liu, Yanhong Ji
BACKGROUND: Occult hepatitis B virus (HBV) infection (OBI) is defined as HBV DNA detection in serum or in the liver by sensitive diagnostic tests in HBV surface antigen (HBsAg) negative patients with or without serologic markers of previous HBV exposure. Because the human leukocyte antigen (HLA) system is an integral component of the immune response, we hypothesized that the highly polymorphic HLA genes were the key determinants of HBV persistence and clearance. The present study aimed to calculate the allelic frequency of HLA loci and investigate the association between HLA alleles and the outcome of OBI in Shaanxi Han population in the northwest of China...
September 2017: Journal of Gene Medicine
https://www.readbyqxmd.com/read/28940489/polymorphisms-in-homologous-recombination-repair-genes-and-the-risk-and-survival-of-breast-cancer
#19
Yu-Huang Liao, Jun-Ting Ren, Wei Zhang, Zheng-Zheng Zhang, Ying Lin, Feng-Xi Su, Wei-Hua Jia, Lu-Ying Tang, Ze-Fang Ren
BACKGROUND: Immunoglobulin (Ig)A antibody of Epstein-Barr virus (EBV) was found to associate with breast cancer (BC), whereas IgA positivity was related to a series of genetic markers in the genes of homologous recombination repair system (HRRs). We assessed the associations of the polymorphisms in HRR genes with the risk and survival of BC. METHODS: A case-control study was conducted with 1551 bc cases and 1605 age-matched healthy controls between October 2008 and March 2012 in the Guangzhou Breast Cancer Study (GZBCS), China, and the case population were followed up until 31 January 2016...
September 2017: Journal of Gene Medicine
https://www.readbyqxmd.com/read/28744963/association-of-incretin-receptors-genetic-polymorphisms-with-type-2-diabetes-mellitus-in-egyptian-patients
#20
Sally M Shalaby, Haidy E Zidan, Amira Shokry, Jehan Saeed, Rehab H El-Sokkary
BACKGROUND: Incretins have opened a new era in type 2 diabetes mellitus (T2DM) pathogenesis. The present study aimed to assess whether there is an association between GIPR rs2302382, GIPR rs1800437 and GLP-1R rs367543060 polymorphisms with T2DM or not and also to determine the effect of these polymorphisms on gastric inhibitory polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) levels. METHODS: One hundred and fifty T2DM patients and 150 healthy controls were included in the study...
September 2017: Journal of Gene Medicine
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