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Biological Research for Nursing

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https://www.readbyqxmd.com/read/29635940/primer-in-genetics-and-genomics-series-final-remarks
#1
Sheila A Alexander
No abstract text is available yet for this article.
May 2018: Biological Research for Nursing
https://www.readbyqxmd.com/read/29514460/altered-dna-methylation-patterns-associated-with-clinically-relevant-increases-in-ptsd-symptoms-and-ptsd-symptom-profiles-in-military-personnel
#2
Christiana Martin, Young-Eun Cho, Hyungsuk Kim, Sijung Yun, Rebekah Kanefsky, Hyunhwa Lee, Vincent Mysliwiec, Ann Cashion, Jessica Gill
Military personnel experience posttraumatic stress disorder (PTSD), which is associated with differential DNA methylation across the whole genome. However, the relationship between these DNA methylation patterns and clinically relevant increases in PTSD severity is not yet clearly understood. The purpose of this study was to identify differences in DNA methylation associated with PTSD symptoms and investigate DNA methylation changes related to increases in the severity of PTSD in military personnel. In this pilot study, a cross-sectional comparison was made between military personnel with PTSD (n = 8) and combat-matched controls without PTSD (n = 6)...
May 2018: Biological Research for Nursing
https://www.readbyqxmd.com/read/29514459/primer-in-genetics-and-genomics-article-7-multifactorial-concepts-gene-gene-interactions
#3
Ansley Grimes Stanfill, Athena Starlard-Davenport
Most common disorders affecting human health are not attributable to simple Mendelian (single-gene) inheritance patterns. Rather, the risk of developing a complex disease is often the result of interactions across genes, whereby one gene modifies the phenotype of another gene. These types of interactions can occur between two or more genes and are referred to as epistasis. There are five major types of epistatic interactions, but in human genetics, additive epistasis is most often discussed and includes both positive and negative subtypes...
May 2018: Biological Research for Nursing
https://www.readbyqxmd.com/read/29490472/comparison-of-hair-cortisol-levels-and-perceived-stress-in-mothers-who-deliver-at-preterm-and-term
#4
Allyson R Duffy, Donna L Schminkey, Maureen W Groer, Melissa Shelton, Samia Dutra
OBJECTIVE: To evaluate relationships between hair cortisol levels and perceived stress in mothers who deliver preterm and term. We hypothesized that the rate of change in cortisol levels would be greater in the preterm delivery group. METHODS: This preliminary study compared hair cortisol levels and Perceived Stress Scale (PSS) scores in predominately Caucasian mothers who delivered preterm ( n = 22) and term ( n = 30). We collected PSS and hair samples of ≥10 cm in length from mothers after delivery...
May 2018: Biological Research for Nursing
https://www.readbyqxmd.com/read/29490471/a-systematic-review-of-placental-biomarkers-predicting-small-for-gestational-age-neonates
#5
Rungnapa Ruchob, Julienne N Rutherford, Aleeca F Bell
BACKGROUND: Neonates born small for gestational age (SGA) face increased risk of neonatal mortality, childhood developmental problems, and adult disease. The placenta is a key factor in SGA development because of its multiple biological processes that underlie fetal growth. However, valid and reliable placental biomarkers of SGA have not been determined. OBJECTIVES: The objective of this article was to systematically identify and review studies examining associations between placental biomarkers and SGA and assess those biomarkers' predictive value...
May 2018: Biological Research for Nursing
https://www.readbyqxmd.com/read/29480031/different-sickness-responses-in-adult-and-aged-rats-following-lipopolysaccharide-administration
#6
Barbara J Kupferschmid, Barbara Therrien, Pamela J Rowsey
OBJECTIVE: Immune challenges result in sickness responses such as decreased activity, fever, and spatial learning deficits. While these responses occur simultaneously, they are not usually evaluated concurrently or for an extended time. The purpose of this study was to examine how an immune challenge affected activity and temperature responses in animals tested concurrently in the Morris water maze (MWM) over 5 days and how aging interacts with such responses. METHOD: An accepted model of aging, adult ( n = 10; 5-6 months) and aged ( n = 7; 22 months) male Brown-Norway rats were implanted with a telemetry device (Mini Mitter, Oakmont, PA) to continuously monitor temperature and activity following an immune challenge...
May 2018: Biological Research for Nursing
https://www.readbyqxmd.com/read/29430940/positive-effects-of-a-short-term-intense-elastic-resistance-training-program-on-body-composition-and-physical-functioning-in-overweight-older-women
#7
Nicole B Fritz, Álvaro Juesas, Pedro Gargallo, Joaquín Calatayud, Julio Fernández-Garrido, Michael E Rogers, Juan C Colado
The aim of this study was to investigate the effects of a resistance training program (RTP) in older overweight women (OOW) using two different types of elastic devices. METHODS: This study was a randomized controlled trial with pre- and postintervention measures. Participants included OOW, aged 60-85 years, with no medical history of disease that would preclude them from engaging in physical exercise. Participants were randomly divided into the following groups: elastic tubes with handles group (ETG; n = 22), traditional elastic bands group ( n = 21), and control group (CG; n = 20)...
May 2018: Biological Research for Nursing
https://www.readbyqxmd.com/read/29409343/the-effects-of-enriched-environmental-intervention-on-the-parturition-outcome-and-filial-health-of-pregnant-mice-with-chronic-pain
#8
Fang Zhou, Cui Chen, Yue Huang, Huihui Hu, Li Li, Yingchun Tan
Chronic pain (CP) adversely impacts people's health. However, the influence of CP on pregnant women and their fetuses remains unclear. Few reasonable interventions have been offered to these women. This study aimed to examine the effects of enriched environmental intervention (EEI) on the delivery outcome and offspring health of pregnant mice with CP. Forty pregnant mice were equally and randomly divided into four groups (control, sham, CP, and CP + EEI). Monoarthritis was induced by subcutaneous injection of the complete Freund's adjuvant (100 μg/100 μl) into the left hind paw of mice on Day 0 of gestation...
May 2018: Biological Research for Nursing
https://www.readbyqxmd.com/read/29402137/perceived-stress-its-physiological-correlates-and-quality-of-life-in-patients-with-irritable-bowel-syndrome
#9
Kristen R Weaver, Gail D'Eramo Melkus, Jason Fletcher, Wendy A Henderson
Irritable bowel syndrome (IBS) is a chronic, common disorder of the gastrointestinal tract associated with high psychological comorbidity and diminished quality of life. Patients with IBS display a heightened sensitivity to stress, although the literature is inconsistent as to whether they have a dysregulated stress response. The purpose of the present investigation, a substudy of a larger research effort, was to examine physiological correlates of perceived stress in patients with IBS (cortisol and adrenocorticotropic hormone) and to explore associations between perceived stress and quality of life...
May 2018: Biological Research for Nursing
https://www.readbyqxmd.com/read/29378417/epigenetic-modifications-following-noxious-stimuli-in-infants
#10
Linda A Hatfield, Rebecca K Hoffman, Rosemary C Polomano, Yvette Conley
PURPOSE: To recruit healthy full- and preterm infants into genetic research and determine the effectiveness of a noninvasive DNA sampling technique for comparing epigenetic modifications. BACKGROUND: Noxious stimuli during a vulnerable period of infant neuronal plasticity may trigger long-term epigenetic changes affecting neurodevelopment, pain modulation, and reactivity. Recognizing epigenetic pain findings is problematic because parents are reluctant to enroll newborns into genetic research...
March 2018: Biological Research for Nursing
https://www.readbyqxmd.com/read/29366332/genetics-and-genomics-in-nursing-science
#11
Wendy A Henderson, Gia Mudd-Martin
No abstract text is available yet for this article.
March 2018: Biological Research for Nursing
https://www.readbyqxmd.com/read/29361834/the-effect-of-moderate-versus-high-intensity-resistance-training-on-systemic-redox-state-and-dna-damage-in-healthy-older-women
#12
Pedro Gargallo, Juan C Colado, Alavaro Juesas, Amaya Hernando-Espinilla, Nuria Estañ-Capell, Lidia Monzó-Beltran, Paula García-Pérez, Omar Cauli, Guillermo T Sáez
This study investigated effects of a 16-week progressive resistance training program (RTP) with elastic bands at two different intensities on systemic redox state, DNA damage, and physical function in healthy older women. METHODS: Participants were randomly assigned to the high-intensity group (HIGH; n = 39), moderate-intensity group (MOD; n = 31), or control group (CG; n = 23). The exercise groups performed an RTP twice a week with three to four sets of 6 (HIGH) or 15 (MOD) repetitions of six overall body exercises at a perceived exertion rate of 8-9 on the OMNI-Resistance Exercise Scale for use with elastic bands...
March 2018: Biological Research for Nursing
https://www.readbyqxmd.com/read/29357674/associating-symptom-phenotype-and-genotype-in-preeclampsia
#13
Sandra A Founds, Eleni Tsigas, Dianxu Ren, M Michael Barmada
Preeclampsia is a complex genetic disorder with an incompletely understood pathogenesis. Its phenotype may be better elucidated by integrating symptoms. This study aimed to identify symptoms by gestational age and associations with novel preeclampsia candidate genes. Women with a history of preeclampsia recruited from The Preeclampsia Registry completed clinical/demographic, symptom surveys and provided medical records. DNA extracted from saliva was processed with multiplexed assays for eight single-nucleotide polymorphisms (SNPs) selected to tag candidate genes and/or located in symptom susceptibility regions...
March 2018: Biological Research for Nursing
https://www.readbyqxmd.com/read/29338330/joint-influence-of-snps-and-dna-methylation-on-lipids-in-african-americans-from-hypertensive-sibships
#14
Michelle L Wright, Erin B Ware, Jennifer A Smith, Sharon L R Kardia, Jacquelyn Y Taylor
INTRODUCTION: Plasma concentrations of lipids (i.e., total cholesterol, high-density cholesterol, low-density cholesterol, and triglycerides) are amenable to therapeutic intervention and remain important factors for assessing risk of cardiovascular diseases. Some of the observed variability in serum lipid concentrations has been associated with genetic and epigenetic variants among cohorts with European ancestry (EA). Serum lipid levels have also been associated with genetic variants in multiethnic populations...
March 2018: Biological Research for Nursing
https://www.readbyqxmd.com/read/29334760/polymorphisms-in-estrogen-synthesis-genes-and-symptom-clusters-during-the-menopausal-transition-and-early-postmenopause-observations-from-the-seattle-midlife-women-s-health-study
#15
Nancy Fugate Woods, Lori A Cray, Ellen Sullivan Mitchell, Fred Farrin, Jerald Herting
During the menopausal transition and early postmenopause, participants in the Seattle Midlife Women's Health Study (SMWHS) experienced one of the three symptom severity clusters identified through latent class analysis: severe hot flashes with moderate sleep, mood, cognitive, and pain symptoms (high-severity hot flash); low-severity hot flashes with moderate levels of all other symptom groups (moderate severity); and low levels of all symptom groups (low severity). In an effort to determine whether gene polymorphisms were associated with these symptom severity classes, we tested associations between gene polymorphisms in the estrogen synthesis pathways (cytochrome P450 19 [CYP 19] and 17 beta hydroxysteroid dehydrogenase [ 17HSDB1]) and the three symptom severity clusters...
March 2018: Biological Research for Nursing
https://www.readbyqxmd.com/read/29325452/inherited-cancer-in-the-age-of-next-generation-sequencing
#16
Kristin S Price, Ashley Svenson, Elisabeth King, Kaylene Ready, Gabriel A Lazarin
Next-generation sequencing (NGS) technology has led to the ability to test for multiple cancer susceptibility genes simultaneously without significantly increasing cost or turnaround time. With growing usage of multigene testing for inherited cancer, ongoing education for nurses and other health-care providers about hereditary cancer screening is imperative to ensure appropriate testing candidate identification, test selection, and posttest management. The purpose of this review article is to (1) provide an overview of how NGS works to detect germline mutations, (2) summarize the benefits and limitations of multigene panel testing, (3) describe risk categories of cancer susceptibility genes, and (4) highlight the counseling considerations for patients pursuing multigene testing...
March 2018: Biological Research for Nursing
https://www.readbyqxmd.com/read/29325451/expression-of-sestrin-genes-in-radiotherapy-for-prostate-cancer-and-its-association-with-fatigue-a-proof-of-concept-study
#17
Velda J Gonzalez, Farnoosh Abbas-Aghababazadeh, Brooke L Fridley, Tomar Ghansah, Leorey N Saligan
Genetic factors that influence inflammation and energy production/expenditure in cells may affect patient outcomes following treatment with external beam radiation therapy (EBRT). Sestrins, stress-inducible genes with antioxidant properties, have recently been implicated in several behaviors including fatigue. This proof-of-concept study explored whether the sestrin family of genes ( SESN1, SESN2, and SESN3) were differentially expressed from baseline to the midpoint of EBRT in a sample of 26 Puerto Rican men with nonmetastatic prostate cancer...
March 2018: Biological Research for Nursing
https://www.readbyqxmd.com/read/29325450/symptom-science-omics-supports-common-biological-underpinnings-across-symptoms
#18
Maura K McCall, Ansley Grimes Stanfill, Elizabeth Skrovanek, Jessica Renee Pforr, Susan W Wesmiller, Yvette P Conley
For precision health care to be successful, an in-depth understanding of the biological mechanisms for symptom development and severity is essential. Omics-based research approaches facilitate identification of the biological underpinnings of symptoms. We reviewed literature for omics-based approaches and exemplar symptoms (sleep disruption, cognitive impairment, fatigue, gastrointestinal [GI] distress, and pain) to identify genes associated with the symptom or symptoms across disease processes. The review yielded 27 genes associated with more than one symptom...
March 2018: Biological Research for Nursing
https://www.readbyqxmd.com/read/29298497/effects-of-gender-specific-differences-inflammatory-response-and-genetic-variation-on-the-associations-among-depressive-symptoms-and-the-risk-of-major-adverse-coronary-events-in-patients-with-acute-coronary-syndrome
#19
Jennifer Sanner, Megan L Grove, Erica Yu, F Gerard Moeller, Stanley G Cron, Eric Boerwinkle, Alanna C Morrison, Lorraine Frazier
Depressive symptoms independently contribute to major adverse coronary events (MACEs), with the biological immune response to depression being a likely mediator of this relationship. To determine whether genetic- and/or gender-specific phenotypic differences contribute to associations among depressive symptoms, inflammatory response, and risk of MACE in patients with acute coronary syndrome (ACS), we conducted a prospective study of 1,117 ACS patients to test a gender-specific model in which depressive symptoms (Beck Depression Inventory-II [BDI-II]) are associated with risk of MACE...
March 2018: Biological Research for Nursing
https://www.readbyqxmd.com/read/29258400/evaluation-of-apoe-genotype-and-ability-to-perform-activities-of-daily-living-following-aneurysmal-subarachnoid-hemorrhage
#20
Lacey Wright Heinsberg, Eleanor Turi, Dianxu Ren, Elizabeth Crago, Sheila Alexander, Ansley Grimes Stanfill, Yvette Perry Conley
Survivors of aneurysmal subarachnoid hemorrhage (aSAH) often experience unfavorable functional outcomes that result in a reduced ability to independently perform activities of daily living. The apolipoprotein E gene ( APOE) encodes for a protein known to facilitate lipid transport and aid in neuronal repair within the central nervous system and to moderate the inflammatory response, making functional variations in this gene likely candidate biomarkers to predict outcomes following aSAH. In the present work, we examined the relationship between APOE genotype and the ability to perform activities of daily living as measured by the Barthel Index (BI) score at 3 months ( n = 298) and 12 months ( n = 288) following aSAH...
March 2018: Biological Research for Nursing
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