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Biological Research for Nursing

R Jeanne Ruiz, Jerome Trzeciakowski, Tiffany Moore, Kimberly S Ayers, Rita H Pickler
Chronic stress may accelerate cellular aging. Telomeres, protective "caps" at the end of chromosomes, modulate cellular aging and may be good biomarkers for the effects of chronic stress, including that associated with acculturation. The purpose of this analysis was to examine telomere length (TL) in acculturating Hispanic Mexican American women and to determine the associations among TL, acculturation, and psychological factors. As part of a larger cross-sectional study of 516 pregnant Hispanic Mexican American women, we analyzed DNA in blood samples (N = 56) collected at 22-24 weeks gestation for TL as an exploratory measure using monochrome multiplex quantitative telomere polymerase chain reaction (PCR)...
October 12, 2016: Biological Research for Nursing
Wei-Fen Ma, Po-Lun Wu, Chia-Hsien Su, Tzu-Ching Yang
The purpose of this study was to evaluate the effects of a home-based (HB) exercise program on anxiety levels and metabolic functions in patients with anxiety disorders in Taiwan. Purposive sampling was used to recruit 86 participants for this randomized, experimental study. Participants were asked to complete a pretest before the 3-month exercise program, a posttest at 1 week, and a follow-up test at 3 months after the exercise program. Study measures included four Self-Report Scales and biophysical assessments to collect and assess personal data, lifestyle behaviors, anxiety levels, and metabolic control functions...
October 11, 2016: Biological Research for Nursing
José Miguel Rivera-Caravaca, Inmaculada Viedma-Viedma, Vanessa Roldán
INTRODUCTION: Treatment of venous thromboembolism (VTE) is classically based on oral vitamin K antagonists (VKAs). Due to the disadvantages and side effects of these drugs, monitoring the quality of anticoagulation by assessing time within therapeutic range (TTR) is recommended. Variables altering the TTR in patients with VTE are yet to be determined. The aim of this study was to analyze the quality of anticoagulation in patients with VTE treated with VKAs and to identify factors associated with poor-quality anticoagulation...
September 28, 2016: Biological Research for Nursing
Chiu-Hsiang Lee, Chien-Ying Lee, Ming-Yi Hsu, Chiung-Ling Lai, Yi-Hui Sung, Chung-Ying Lin, Long-Yau Lin
Patients in intensive care units (ICUs) often experience stress and anxiety. Although stress and anxiety can be pharmacologically attenuated, some drugs cause adverse side effects such as bradycardia, immobility, and delirium. There is thus a need for an alternative treatment with no substantial adverse effects. Music intervention is a potential alternative. In the present study, we used cortisol levels, subjective questionnaires, and physiological parameters to explore the anxiety-reducing effects of music intervention in a sample of ICU patients on mechanical ventilation...
September 20, 2016: Biological Research for Nursing
Veronica Barcelona de Mendoza, Michelle L Wright, Comfort Agaba, Laura Prescott, Alexandra Desir, Cindy A Crusto, Yan V Sun, Jacquelyn Y Taylor
BACKGROUND: The causes of many cases of preterm birth (PTB) remain enigmatic. Increased understanding of how epigenetic factors are associated with health outcomes has resulted in studies examining DNA methylation (DNAm) as a contributing factor to PTB. However, few studies on PTB and DNAm have included African American women, the group with the highest rate of PTB. METHODS: The objective of this review was to systematically analyze the existing studies on DNAm and PTB among African American women...
September 19, 2016: Biological Research for Nursing
Nicole D Osier, Christopher C Imes, Heba Khalil, Jamie Zelazny, Ann E Johansson, Yvette P Conley
Omics approaches, including genomics, transcriptomics, proteomics, epigenomics, microbiomics, and metabolomics, generate large data sets. Once they have been used to address initial study aims, these large data sets are extremely valuable to the greater research community for ancillary investigations. Repurposing available omics data sets provides data to address research questions, generate and test hypotheses, replicate findings, and conduct mega-analyses. Many well-characterized, longitudinal, epidemiological studies collected extensive phenotype data related to symptom occurrence and severity...
September 9, 2016: Biological Research for Nursing
Kelley L Baumgartel, Maureen W Groer, Susan M Cohen, Dianxu Ren, Diane L Spatz, Yvette P Conley
BACKGROUND: Maternal interleukin (IL) single nucleotide polymorphisms (SNPs) are associated with obstetrical outcomes. Conversely, infant SNPs are associated with subsequent neonatal intensive care unit (NICU) outcomes. Little is known about relationships between maternal SNPs and neonatal outcomes. PURPOSE: To examine the relationships between maternal IL genotypes and neonatal outcomes. METHODS: An ancillary study was conducted among mothers (N = 63) who delivered very low-birth-weight infants (N = 74)...
September 6, 2016: Biological Research for Nursing
Rebecca L Dekker, Terry A Lennie, Debra K Moser, Craig S Miller, Jeffrey L Ebersole, Misook L Chung, Charles L Campbell, Alison Bailey, Elizabeth G Tovar
AIMS: To describe correlations and agreement between salivary and serum B-type natriuretic peptide (BNP), C-reactive protein (CRP), interleukin (IL)-6, and IL-10 and determine which biomarkers predict worse functional class in patients with heart failure (HF). METHODS: Serum and saliva were collected from 75 hospitalized patients with HF (57 ± 12 years, 43% female, New York Heart Association [NYHA] Classes I [4%], II [43%], and III [53%]). Oral inflammation was rated as good, fair, or poor...
September 6, 2016: Biological Research for Nursing
Aaron Conway, Judith Sheridan, Joanne Maddicks-Law, Paul Fulbrook, Chantal F Ski, David R Thompson, Robyn A Clark, Lynn V Doering
: Characterizing how physical and psychological symptoms interact in heart transplant recipients may lead to advances in therapeutic options. This study examined associations between pain and major depression. METHOD: A cross-sectional study was conducted with adult heart transplant recipients. Pain was measured with the bodily pain domain of the Short Form-36 Health Survey and psychological distress with the Kessler Psychological Distress Scale (K-10). The Mini International Neuropsychiatric Interview, version 6...
August 31, 2016: Biological Research for Nursing
Shannon Halloway, JoEllen Wilbur, Michael E Schoeny, Konstantinos Arfanakis
Physical activity intervention studies that focus on improving cognitive function in older adults have increasingly used magnetic resonance imaging (MRI) measures in addition to neurocognitive measures to assess effects on the brain. The purpose of this systematic review was to identify the effects of endurance-focused physical activity randomized controlled trial (RCT) interventions on the brain as measured by MRI in community-dwelling middle-aged or older adults without cognitive impairment. Five electronic databases were searched...
July 29, 2016: Biological Research for Nursing
Chandylen L Nightingale, Deidre B Pereira, Barbara A Curbow, John R Wingard, Giselle D Carnaby
PURPOSE: Head and neck cancer (HNC) patients suffer from significant morbidity, which may introduce challenging care demands and subsequent stress-induced mind-body interactions for informal caregivers. This prospective study evaluated patient and caregiver predictors of diurnal cortisol rhythm among HNC caregivers during radiation treatment. METHOD: Patient-caregiver dyads completed measures at radiation treatment start (T1; n = 32) and 5 weeks into treatment (T2; n = 29)...
July 27, 2016: Biological Research for Nursing
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October 2016: Biological Research for Nursing
Glenda Lindseth, Thomas Petros
BACKGROUND: Research results on the neurobehavioral effects of consuming dietary fatty acids are mixed. Therefore, this study examined the effects of consuming dietary fatty acids on depression, mood, and anxiety. METHODS: In this randomized crossover-design study, 37 university students served as their own controls, consuming each of the following diets for a 4-day period with a 2-week washout period between diets: (1) low fatty acid, (2) high saturated fatty acid (SFA), (3) high polyunsaturated fatty acid (PUFA), and (4) control...
October 2016: Biological Research for Nursing
Maryam Amini, Abolghassem Djazayery, Reza Majdzadeh, Mohammad-Hossein Taghdisi, Haleh Sadrzadeh-Yeganeh, Zahra Abdollahi, Nasrin Hosseinpour-Niazi, Maryam Chamari, Mahdieh Nourmohammadi
BACKGROUND: This study evaluated the effect of an intervention for reducing excess weight gain in primary school-age children in Tehran. METHODS: A cluster-randomized controlled trial was conducted in 12 primary schools in Tehran. Three hundred thirty-four pupils, 167 in the intervention and 167 in the comparison group, determined to be overweight or obese based on World Health Organization standards, were recruited for the study. The intervention included nutrition education and increased physical activity (PA) for the pupils, lifestyle modification for parents, and a change in food items sold at the schools' canteens...
October 2016: Biological Research for Nursing
Tzu-Ting Wu, I-Ju Chen, Shu-Ling Cho, Ai-Fu Chiou
BACKGROUND: Poor health-promoting behaviors increase the risk of chronic disease and disability in older adults. Nevertheless, the predictors of health-promoting behaviors and their relationship with metabolic syndrome have been poorly characterized in older Taiwanese adults. OBJECTIVE: To explore the determinants of health-promoting behaviors in community-dwelling older adults in Taiwan and the relationship of health-promoting behaviors with metabolic syndrome...
October 2016: Biological Research for Nursing
Chiu-Yueh Yang, Su-Chen Lo, Ying-Chieh Peng
BACKGROUND: Atypical antipsychotic medications increase the risk of developing metabolic syndrome (MetS) and cardiovascular diseases in people with schizophrenia. AIM: To explore the prevalence of MetS and the predictors associated with the number of MetS components in people with chronic schizophrenia. METHODS: We recruited 357 participants from 10 rehabilitation wards in northern Taiwan. The Beck Anxiety Inventory, Beck Depression Inventory-II, Health-Promoting Lifestyle Profile (HPLP), and modified Baecke physical activity questionnaire were used to evaluate the participants...
October 2016: Biological Research for Nursing
Emilio González-Jiménez, Jacqueline Schmidt-RioValle, Miguel A Montero-Alonso, Cristina Padez, Carmen J García-García, Javier S Perona
BACKGROUND: Insulin resistance plays a determinant role in the development of metabolic syndrome in adolescents. The objective of the present study was to determine the influence of factors commonly associated with insulin resistance in a sample of adolescents. METHODS: This cross-sectional study included 976 adolescents from southeast Spain. Anthropometric and biochemical measurements were performed, and insulin resistance was assessed using the homeostasis model assessment-insulin resistance (HOMA-IR)...
October 2016: Biological Research for Nursing
Ching-Wen Chang, Shun-Fa Yang, Po-Hui Wang, Hsiu-Ju Chang, Wen-Chi Liu, Hsiu-Ting Tsai
Cervical neoplasia is one of the most prevalent malignant neoplasms worldwide. Ribonucleotide reductase 1 (RRM1) is thought to play an essential role in modulating the development and progression of cervical neoplasia. Two novel genetic polymorphisms, RRM1 -756T>C and -269 C>A, are significantly correlated with RRM1 expression. Some epidemiological studies have demonstrated that genetic variants play a crucial role in susceptibility to cervical cancer. The present study aimed to identify the genetic polymorphisms RRM1 -756T>C and -269 C>A in patients with cervical neoplasia and healthy controls...
October 2016: Biological Research for Nursing
Cheryl Rodgers, Chelse Sanborn, Olga Taylor, Patricia Gundy, Alice Pasvogel, Ida M Ki Moore, Marilyn J Hockenberry
Fatigue is a frequent and distressing symptom in children undergoing leukemia treatment; however, little is known about factors influencing this symptom. Antioxidants such as glutathione can decrease symptom severity in adult oncology patients, but no study has evaluated antioxidants' effects on symptoms in pediatric oncology patients. This study describes fatigue patterns and associations of fatigue with antioxidants represented by reduced glutathione (GSH) and the reduced/oxidized glutathione (GSH/GSSG) ratio among children receiving leukemia treatment...
October 2016: Biological Research for Nursing
Ida M Ki Moore, Carrie J Merkle, Howard Byrne, Adam Ross, Ashley M Hawkins, Sara S Ameli, David W Montgomery
Central nervous system (CNS)-directed treatment for acute lymphoblastic leukemia, used to prevent disease recurrence in the brain, is essential for survival. Systemic and intrathecal methotrexate, commonly used for CNS-directed treatment, have been associated with cognitive problems during and after treatment. The cortex, hippocampus, and caudate putamen, important brain regions for learning and memory, may be involved in methotrexate-induced brain injury. Objectives of this study were to (1) quantify neuronal degeneration in selected regions of the cortex, hippocampus, and caudate putamen and (2) measure changes in the expression of genes with known roles in oxidant defense, apoptosis/inflammation, and protection from injury...
October 2016: Biological Research for Nursing
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