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Biological Research for Nursing

John D Merriman, Susan M Sereika, Yvette P Conley, Theresa A Koleck, Yehui Zhu, Mary L Phillips, Michele A Bertocci, Adam M Brufsky, Catherine M Bender
PURPOSE: Women with breast cancer report varying frequencies of cognitive problems during adjuvant systemic therapy. This variability suggests latent subgroups. Therefore, we identified latent subgroups of self-reported cognitive problems among postmenopausal women with and without breast cancer. We explored associations between membership in these subgroups and (a) demographic, clinical, and symptom characteristics and (b) variations in candidate gene polymorphisms. METHODS: We evaluated frequency of cognitive problems using the Patient Assessment of Own Functioning Inventory...
September 13, 2018: Biological Research for Nursing
Jinjiao Wang, Cathy A Maxwell, Fang Yu
The objectives of this literature review were to (1) synthesize biological processes linked to frailty and their corresponding biomarkers and (2) identify potential associations among these processes and biomarkers. In September 2016, PubMed, Cumulative Index to Nursing and Allied Health, Cochrane Library, and Embase were searched. Studies examining biological processes related to frailty in older adults (≥60 years) were included. Studies were excluded if they did not employ specific measures of frailty, did not report the association between biomarkers and frailty, or focused on nonelderly samples (average age < 60)...
September 9, 2018: Biological Research for Nursing
Cecile A Lengacher, Richard R Reich, Carly L Paterson, Melissa Shelton, Steve Shivers, Sophia Ramesar, Michelle L Pleasant, Pinky Budhrani-Shani, Maureen Groer, Janice Post-White, Versie Johnson-Mallard, Bradley Kane, Lakeshia Cousin, Manolete S Moscoso, Tiffany A Romershausen, Jong Y Park
Breast cancer survivors (BCS) often experience psychological and physiological symptoms after cancer treatment. Mindfulness-based stress reduction (MBSR), a complementary and alternative therapy, has reduced subjective measures of stress, anxiety, and fatigue among BCS. Little is known, however, about how MBSR affects objective markers of stress, specifically the stress hormone cortisol and the pro-inflammatory cytokine interleukin-6 (IL-6). In the present study, BCS ( N = 322) were randomly assigned to a 6-week MBSR program for BC or usual-care control...
August 5, 2018: Biological Research for Nursing
EunSeok Cha, Molly Sarah Talman, Ann H Massey, Fengxia Yan, Ann E Rogers
AIM: This pilot study examined associations between sleep quality and metabolic risk profiles, underlying hormones, inflammatory markers, and behaviors in overweight and obese young adults, aged 18-29 years. DESIGN: Cross-sectional, descriptive, correlational study design. METHOD: A partial sample ( n = 29) was re-recruited from a parent study on screening for risk of early-onset diabetes. BodyMedia's SenseWear® armband was used to assess sleep quality...
October 2018: Biological Research for Nursing
Tiffany A Moore, Iman M Ahmad, Matthew C Zimmerman
BACKGROUND: A variety of methods and measures have been used to quantify oxidative stress in clinical studies related to preterm birth (PTB), and studies have reported conflicting findings. No integrative reviews have been conducted. OBJECTIVE: To describe specific molecules used as markers of oxidative stress and methods to measure these molecules and to review the literature for associations between oxidative stress and PTB specific to these molecules. METHOD: Systematic literature searches were conducted in June 2015 and updated in 2017 in databases from the Biomedical Reference Collection: Basic Edition, including MEDLINE and clinicaltrials...
October 2018: Biological Research for Nursing
Idoia Zarrazquin Arizaga, Ainhoa Fernández Atucha, Maider Kortajarena, Jon Torres-Unda, Amaia Irazusta, Fátima Ruiz-Litago, Jon Irazusta, Luis Casis, Ana Belen Fraile-Bermúdez
The aim of this cross-sectional study was to study the relative importance of dietary habits and aerobic capacity in parameters related to cardiovascular risk in 271 female and 95 male health-science students (mean age = 19.1 ± 1.4 years). In females, fatty-meat consumption predicted triglycerides (β = .649, p < .001) and high-density lipoprotein (HDL; β = -.242, p = .001) and low-density lipoprotein (LDL; β = .373, p < .001) cholesterol levels. Consumption of nuts, legumes, and complex carbohydrates predicted triglyceride (β = -...
October 2018: Biological Research for Nursing
Alma Rus, Francisco Molina, María Luisa Del Moral, María Jesús Ramírez-Expósito, José Manuel Martínez-Martos
OBJECTIVES: Fibromyalgia (FM) is a complex syndrome characterized by widespread pain. Its etiology is unclear, and diagnosis is difficult. The aim of this study was to assess plasma levels of monoamine neurotransmitters (catecholamines, indolamines, and intermediate metabolites) in patients with FM and healthy controls to investigate possible alterations in the metabolism of these molecules in FM. We also examined potential relationships between monoamine neurotransmitters and clinical features of FM...
October 2018: Biological Research for Nursing
Karin Reuter-Rice, Michael Regier, Ellen Bennett, Daniel Laskowitz
BACKGROUND: Pediatric traumatic brain injury (TBI) is a leading cause of death and disability. Polymorphisms in the apolipoprotein E ( APOE) gene have been linked to cerebral vasospasm (CV) and poor outcomes in adults with TBI, yet these associations remain poorly defined in children. OBJECTIVE: We examined the effect of the relationship between APOE polymorphisms and CV on functional outcomes in children with a TBI. METHOD: This prospective, descriptive study examined 60 children (aged 10 days to 15 years) with a TBI...
October 2018: Biological Research for Nursing
Michelle L Wright, Christina Fournier, Madelyn C Houser, Malú Tansey, Jonathan Glass, Vicki Stover Hertzberg
Amyotrophic lateral sclerosis (ALS) etiology and pathophysiology are not well understood. Recent data suggest that dysbiosis of gut microbiota may contribute to ALS etiology and progression. This review aims to explore evidence of associations between gut microbiota and ALS etiology and pathophysiology. Databases were searched for publications relevant to the gut microbiome in ALS. Three publications provided primary evidence of changes in microbiome profiles in ALS. An ALS mouse model revealed damaged tight junction structure and increased permeability in the intestine versus controls along with a shifted microbiome profile, including decreased levels of butyrate-producing bacteria...
October 2018: Biological Research for Nursing
Chris Winkelman, Abdus Sattar, Hasina Momotaz, Kimberly D Johnson, Peter Morris, James R Rowbottom, John Daryl Thornton, Sheryl Feeney, Alan Levine
OBJECTIVE: Investigate the feasibility of a nurse-led mobility protocol and compare the effects of once- versus twice-daily episodes of early therapeutic mobility (ETM) and low- versus moderate-intensity ETM on serum biomarkers of inflammation and selected outcomes in critically ill adults. DESIGN: Randomized interventional study with repeated measures and blinded assessment of outcomes. SETTING: Four adult intensive care units (ICUs) in two academic medical centers...
October 2018: Biological Research for Nursing
Chizimuzo T C Okoli, Sarret Seng
INTRODUCTION: Secondhand smoke exposure (SHSe) is predictive of greater nicotine dependence (ND) and poor smoking cessation (SC) outcomes. SHSe and its impact on ND and SC attempts in people with psychiatric disorders (PD) remain poorly understood. Hence, the objectives of this study were to (1) quantify SHSe, (2) examine the association of SHSe with ND, and (3) assess the association between SHSe and SC among tobacco users with PD. METHOD: A cross-sectional survey of 118 tobacco users in an inpatient psychiatric facility was conducted...
October 2018: Biological Research for Nursing
Eileen M Condon
PROBLEM: Incorporating biomarkers of chronic stress into pediatric research studies may help to explicate the links between exposure to adversity and lifelong health, but there are currently very few parameters to guide nurse researchers in choosing appropriate biomarkers of chronic stress for use in research with children and adolescents. METHODS: Biomarkers of chronic stress are described, including primary mediators (glucocorticoids, catecholamines, and cytokines) and secondary outcomes (neurologic, immune, metabolic, cardiovascular, respiratory, and anthropometric) of the chronic stress response...
October 2018: Biological Research for Nursing
Paule V Joseph, Hannah R Davidson, Christina M Boulineaux, Nicolaas H Fourie, Alexis T Franks, Sarah K Abey, Wendy A Henderson
The purpose of the study was to examine the interrelationships among stress, eating behavior, and adiposity in a cohort of normal- and overweight individuals. Clinical markers of physiological stress (fasting serum cortisol) and adiposity (body mass index [BMI] and percent body fat) were obtained from participants selected for a natural history protocol ( n = 107). Self-reported data on eating behavior (using the Three-Factor Eating Questionnaire subscales such as Cognitive Restraint, Disinhibition, and Hunger) and psychological stress (via the Perceived Stress Scale) were evaluated...
October 2018: Biological Research for Nursing
Ainitze Labaka, Olatz Goñi-Balentziaga, Andrea Lebeña, Joana Pérez-Tejada
Depression is the leading cause of disability worldwide, and its prevalence is 2 times higher in women than in men. There is, however, a lack of data on sex-specific pathophysiology of this disorder. The purpose of this systematic review is to identify the biological sex differences found in major depressive disorder (MDD) in studies published in the last 10 years. We conducted a literature search using the Medline, PsycInfo, PubMed, and Web of Science databases, selecting English-language studies that included physiological measures compared by sex in addition to MDD...
July 2018: Biological Research for Nursing
Jesús Serrano Merino, Luis Ángel Pérula de Torres, Wayne A Bardwell, Rafaela Muñoz Gómez, Ana Roldán Villalobos, Nuria Feu Collado, Roger Ruiz-Moral, Bernabé Jurado-Gámez
BACKGROUND: Obstructive sleep apnea (OSA) is a chronic illness that increases in prevalence with age. Treatment includes continuous positive airway pressure (CPAP) devices. Studies about the use of CPAP in the elderly are scarce. The main objective of this study is to determine whether CPAP contributes to improvement in health-related quality of life (HRQL) in elderly patients with OSA. METHOD: This was a prospective, pre-/postintervention assessment of a cohort of patients ≥65 years of age with OSA diagnosis by polysomnography who were being treated with CPAP and were physically independent and had good cognitive status...
July 2018: Biological Research for Nursing
Marilyn J Hockenberry, Ida M Ki Moore, Michael E Scheurer, Mary C Hooke, Olga A Taylor, Kari M Koerner, Patricia M Gundy, Wei Pan
The focus on a cure for childhood leukemia over the last three decades has resulted in survival rates of more than 80%. However, efforts to manage leukemia-treatment symptoms have not kept pace with new therapies. Symptom toxicity during treatment can result in complications, treatment delays, and therapy dose reductions. Compromise in therapy can negatively influence the quality of life and, even more notably, jeopardize chances for long-term survival. This study examined biologic mechanisms that influence fatigue caused by increased reactive oxidative species (ROS) or actual failure of the antioxidant defense system due to genetic variation by investigating reactive nitrosative species, a "downstream" consequence of ROS...
July 2018: Biological Research for Nursing
Youjeong Kang, Bonnie G Steele, Robert L Burr, Cynthia M Dougherty
Cardiopulmonary rehabilitation (CR) improves physical function and quality of life (QoL) in chronic obstructive pulmonary disease (COPD) and heart failure (HF), but it is unknown if CR improves outcomes in very severe disease. This study's purpose was to describe functional capacity (6-min walk distance [6MWD], steps/day), symptoms (dyspnea, depression), QoL (Short-Form Health Survey-Veterans [SF-36 V]) and cardiopulmonary function ( N-terminal pro-brain natriuretic peptide [NT-proBNP], forced expiratory volume in 1 s [FEV1 ]), and derive predictors of mortality among patients with severe COPD and HF who participated in CR...
July 2018: Biological Research for Nursing
Komal P Singh, Christine Miaskowski, Anand A Dhruva, Elena Flowers, Kord M Kober
Research on gene expression (GE) provides insights into the physiology of a cell or group of cells at a given point in time. Studies of changes in GE can be used to identify patients at higher risk for various medical conditions, a higher symptom burden, and/or the adverse consequences associated with various treatments. The aims of this article are as follows: (1) to describe the different types of RNA transcripts, (2) to describe the processes involved in GE (i.e., RNA transcription, epigenetics, and posttranscriptional modifications), (3) to describe common sources of variation in GE, (4) to describe the most common methods used to measure GE, and (5) to discuss factors to consider when choosing tissue for a GE study...
July 2018: Biological Research for Nursing
Jia-Sian Hou, Chih-Hsien Wang, Yu-Hsien Lai, Yu-Li Lin, Chiu-Huang Kuo, Yi-Maun Subeq, Bang-Gee Hsu
PURPOSE: The aim of this study was to evaluate the relationship between serum adiponectin levels and carotid-femoral pulse wave velocity (cfPWV) in hemodialysis (HD) patients. METHOD: Blood samples were obtained from 120 HD patients. cfPWV was measured with a validated tonometry system (SphygmoCor; AtCor Medical, West Ryde, Australia). Serum adiponectin levels were measured using a commercially available enzyme-linked immunosorbent assay kit. RESULTS: By univariate linear analysis of cfPWV in HD patients, we found that diabetes ( r = ...
July 2018: Biological Research for Nursing
An-Yun Yeh, Susan J Pressler, Bruno J Giordani, Bunny J Pozehl, Ann M Berger
Impaired episodic memory in older adults has been linked to many factors. One of these factors is sleep disturbances, which are reported by more than 50% of older adults. The relationship between episodic memory and sleep disturbances remains unclear, however, because of the multiple types of measures of sleep and episodic memory used in previous studies. The purpose of this integrative literature review was to integrate and compare findings on this relationship in adults aged 65 years. An electronic search was conducted in PubMed, Cumulative Index to Nursing and Allied Health Literature, PsychINFO, and Medline for material published from the inception of the databases to December 2016...
July 2018: Biological Research for Nursing
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