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Biological Research for Nursing

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https://www.readbyqxmd.com/read/27913742/frailty-assessment-in-hospitalized-older-adults-using-the-electronic-health-record
#1
Deborah A Lekan, Debra C Wallace, Thomas P McCoy, Jie Hu, Susan G Silva, Heather E Whitson
INTRODUCTION: Frailty, a clinical syndrome of decreased physiologic reserve and dysregulation in multiple physiologic systems, is associated with increased risk for adverse outcomes. PURPOSE: The aim of this retrospective, cross-sectional, correlational study was to characterize frailty in older adults admitted to a tertiary-care hospital using a biopsychosocial frailty assessment and to determine associations between frailty and time to in-hospital mortality and 30-day rehospitalization...
December 2, 2016: Biological Research for Nursing
https://www.readbyqxmd.com/read/27903758/oprm1-and-comt-gene-gene-interaction-is-associated-with-postoperative-pain-and-opioid-consumption-after-orthopedic-trauma
#2
Heba Khalil, Susan M Sereika, Feng Dai, Sheila Alexander, Yvette Conley, Gary Gruen, Li Meng, Peter Siska, Ivan Tarkin, Richard Henker
BACKGROUND: mu-opioid receptor (OPRM1) and catechol-O-methyltransferase (COMT) contribute to the neurotransmission pathway of pain. COMT affects mu receptor expression and density in the brain. The aim of this study was to explore the OPRM1 and COMT interaction effects on postoperative pain and opioid consumption. METHODS: This cross-sectional exploratory study used genotype and clinical data from 153 postoperative patients. Using multiple regression analyses, four single-nucleotide polymorphisms of COMT (rs6269, rs4633, rs4818, and rs4680), their haplotypes, and diplotypes were considered for their interactions with A118G of OPRM1 regarding postoperative pain and opioid consumption...
November 30, 2016: Biological Research for Nursing
https://www.readbyqxmd.com/read/27895219/primer-in-genetics-and-genomics-article-1-dna-genes-and-chromosomes
#3
Janice S Dorman, Mandy J Schmella, Susan W Wesmiller
Precision medicine refers to the practice of determining a patient's unique genetic, biomarker, and other characteristics for the purpose of improving his or her clinical outcomes. Not all patients with the same clinical diagnosis respond equally to identical treatment regimens. By examining patients at the molecular level, health-care providers will be better able to apply the most effective therapies that each individual requires. To understand precision medicine, nurses must have a solid understanding of genomics and proteomics...
November 28, 2016: Biological Research for Nursing
https://www.readbyqxmd.com/read/27803043/metabolic-and-functional-profile-of-premenopausal-women-with-metabolic-syndrome-after-training-with-elastics-as-compared-to-free-weights
#4
Jorge Flandez, Noelia Belando, Pedro Gargallo, Julio Fernández-Garrido, Ronald A Vargas-Foitzick, Jose Devis-Devis, Juan C Colado
The aim of this study was to compare the effects of a strength training program (STP) using free weights (FW) versus elastic tubing (ET) in 62 premenopausal, sedentary women diagnosed with metabolic syndrome (MS). Participants were randomly assigned to the FW or ET experimental group (EG) or a control group whose members remained sedentary. Members of each EG followed their assigned STP for 12 weeks, and biomarkers (BMs) related to MS and motor function (MF) parameters were evaluated. Both EGs showed a significant reduction in C-reactive protein level and a positive trend in the other BMs...
November 1, 2016: Biological Research for Nursing
https://www.readbyqxmd.com/read/27733476/acculturation-predicts-negative-affect-and-shortened-telomere-length
#5
R Jeanne Ruiz, Jerome Trzeciakowski, Tiffany Moore, Kimberly S Ayers, Rita H Pickler
Chronic stress may accelerate cellular aging. Telomeres, protective "caps" at the end of chromosomes, modulate cellular aging and may be good biomarkers for the effects of chronic stress, including that associated with acculturation. The purpose of this analysis was to examine telomere length (TL) in acculturating Hispanic Mexican American women and to determine the associations among TL, acculturation, and psychological factors. As part of a larger cross-sectional study of 516 pregnant Hispanic Mexican American women, we analyzed DNA in blood samples (N = 56) collected at 22-24 weeks gestation for TL as an exploratory measure using monochrome multiplex quantitative telomere polymerase chain reaction (PCR)...
October 12, 2016: Biological Research for Nursing
https://www.readbyqxmd.com/read/27729394/the-effects-of-an-exercise-program-on-anxiety-levels-and-metabolic-functions-in-patients-with-anxiety-disorders
#6
Wei-Fen Ma, Po-Lun Wu, Chia-Hsien Su, Tzu-Ching Yang
The purpose of this study was to evaluate the effects of a home-based (HB) exercise program on anxiety levels and metabolic functions in patients with anxiety disorders in Taiwan. Purposive sampling was used to recruit 86 participants for this randomized, experimental study. Participants were asked to complete a pretest before the 3-month exercise program, a posttest at 1 week, and a follow-up test at 3 months after the exercise program. Study measures included four Self-Report Scales and biophysical assessments to collect and assess personal data, lifestyle behaviors, anxiety levels, and metabolic control functions...
October 11, 2016: Biological Research for Nursing
https://www.readbyqxmd.com/read/27680769/factors-affecting-the-quality-of-anticoagulation-with-vitamin-k-antagonists-in-venous-thromboembolism-patients
#7
José Miguel Rivera-Caravaca, Inmaculada Viedma-Viedma, Vanessa Roldán
INTRODUCTION: Treatment of venous thromboembolism (VTE) is classically based on oral vitamin K antagonists (VKAs). Due to the disadvantages and side effects of these drugs, monitoring the quality of anticoagulation by assessing time within therapeutic range (TTR) is recommended. Variables altering the TTR in patients with VTE are yet to be determined. The aim of this study was to analyze the quality of anticoagulation in patients with VTE treated with VKAs and to identify factors associated with poor-quality anticoagulation...
September 28, 2016: Biological Research for Nursing
https://www.readbyqxmd.com/read/27655993/effects-of-music-intervention-on-state-anxiety-and-physiological-indices-in-patients-undergoing-mechanical-ventilation-in-the-intensive-care-unit-a-randomized-controlled-trial
#8
Chiu-Hsiang Lee, Chien-Ying Lee, Ming-Yi Hsu, Chiung-Ling Lai, Yi-Hui Sung, Chung-Ying Lin, Long-Yau Lin
Patients in intensive care units (ICUs) often experience stress and anxiety. Although stress and anxiety can be pharmacologically attenuated, some drugs cause adverse side effects such as bradycardia, immobility, and delirium. There is thus a need for an alternative treatment with no substantial adverse effects. Music intervention is a potential alternative. In the present study, we used cortisol levels, subjective questionnaires, and physiological parameters to explore the anxiety-reducing effects of music intervention in a sample of ICU patients on mechanical ventilation...
September 20, 2016: Biological Research for Nursing
https://www.readbyqxmd.com/read/27646016/a-systematic-review-of-dna-methylation-and-preterm-birth-in-african-american-women
#9
Veronica Barcelona de Mendoza, Michelle L Wright, Comfort Agaba, Laura Prescott, Alexandra Desir, Cindy A Crusto, Yan V Sun, Jacquelyn Y Taylor
BACKGROUND: The causes of many cases of preterm birth (PTB) remain enigmatic. Increased understanding of how epigenetic factors are associated with health outcomes has resulted in studies examining DNA methylation (DNAm) as a contributing factor to PTB. However, few studies on PTB and DNAm have included African American women, the group with the highest rate of PTB. METHODS: The objective of this review was to systematically analyze the existing studies on DNAm and PTB among African American women...
September 19, 2016: Biological Research for Nursing
https://www.readbyqxmd.com/read/27613438/symptom-science-repurposing-existing-omics-data
#10
Nicole D Osier, Christopher C Imes, Heba Khalil, Jamie Zelazny, Ann E Johansson, Yvette P Conley
Omics approaches, including genomics, transcriptomics, proteomics, epigenomics, microbiomics, and metabolomics, generate large data sets. Once they have been used to address initial study aims, these large data sets are extremely valuable to the greater research community for ancillary investigations. Repurposing available omics data sets provides data to address research questions, generate and test hypotheses, replicate findings, and conduct mega-analyses. Many well-characterized, longitudinal, epidemiological studies collected extensive phenotype data related to symptom occurrence and severity...
September 9, 2016: Biological Research for Nursing
https://www.readbyqxmd.com/read/27628327/reviewer-acknowledgment
#11
(no author information available yet)
No abstract text is available yet for this article.
October 2016: Biological Research for Nursing
https://www.readbyqxmd.com/read/27412317/neurobehavioral-effects-of-consuming-dietary-fatty-acids
#12
Glenda Lindseth, Thomas Petros
BACKGROUND: Research results on the neurobehavioral effects of consuming dietary fatty acids are mixed. Therefore, this study examined the effects of consuming dietary fatty acids on depression, mood, and anxiety. METHODS: In this randomized crossover-design study, 37 university students served as their own controls, consuming each of the following diets for a 4-day period with a 2-week washout period between diets: (1) low fatty acid, (2) high saturated fatty acid (SFA), (3) high polyunsaturated fatty acid (PUFA), and (4) control...
October 2016: Biological Research for Nursing
https://www.readbyqxmd.com/read/27358261/a-school-based-intervention-to-reduce-excess-weight-in-overweight-and-obese-primary-school-students
#13
Maryam Amini, Abolghassem Djazayery, Reza Majdzadeh, Mohammad-Hossein Taghdisi, Haleh Sadrzadeh-Yeganeh, Zahra Abdollahi, Nasrin Hosseinpour-Niazi, Maryam Chamari, Mahdieh Nourmohammadi
BACKGROUND: This study evaluated the effect of an intervention for reducing excess weight gain in primary school-age children in Tehran. METHODS: A cluster-randomized controlled trial was conducted in 12 primary schools in Tehran. Three hundred thirty-four pupils, 167 in the intervention and 167 in the comparison group, determined to be overweight or obese based on World Health Organization standards, were recruited for the study. The intervention included nutrition education and increased physical activity (PA) for the pupils, lifestyle modification for parents, and a change in food items sold at the schools' canteens...
October 2016: Biological Research for Nursing
https://www.readbyqxmd.com/read/27340227/the-relationship-between-health-promoting-behaviors-and-metabolic-syndrome-in-community-dwelling-older-adults
#14
Tzu-Ting Wu, I-Ju Chen, Shu-Ling Cho, Ai-Fu Chiou
BACKGROUND: Poor health-promoting behaviors increase the risk of chronic disease and disability in older adults. Nevertheless, the predictors of health-promoting behaviors and their relationship with metabolic syndrome have been poorly characterized in older Taiwanese adults. OBJECTIVE: To explore the determinants of health-promoting behaviors in community-dwelling older adults in Taiwan and the relationship of health-promoting behaviors with metabolic syndrome...
October 2016: Biological Research for Nursing
https://www.readbyqxmd.com/read/27268516/prevalence-and-predictors-of-metabolic-syndrome-in-people-with-schizophrenia-in-inpatient-rehabilitation-wards
#15
Chiu-Yueh Yang, Su-Chen Lo, Ying-Chieh Peng
BACKGROUND: Atypical antipsychotic medications increase the risk of developing metabolic syndrome (MetS) and cardiovascular diseases in people with schizophrenia. AIM: To explore the prevalence of MetS and the predictors associated with the number of MetS components in people with chronic schizophrenia. METHODS: We recruited 357 participants from 10 rehabilitation wards in northern Taiwan. The Beck Anxiety Inventory, Beck Depression Inventory-II, Health-Promoting Lifestyle Profile (HPLP), and modified Baecke physical activity questionnaire were used to evaluate the participants...
October 2016: Biological Research for Nursing
https://www.readbyqxmd.com/read/27194780/influence-of-biochemical-and-anthropometric-factors-on-the-presence-of-insulin-resistance-in-adolescents
#16
Emilio González-Jiménez, Jacqueline Schmidt-RioValle, Miguel A Montero-Alonso, Cristina Padez, Carmen J García-García, Javier S Perona
BACKGROUND: Insulin resistance plays a determinant role in the development of metabolic syndrome in adolescents. The objective of the present study was to determine the influence of factors commonly associated with insulin resistance in a sample of adolescents. METHODS: This cross-sectional study included 976 adolescents from southeast Spain. Anthropometric and biochemical measurements were performed, and insulin resistance was assessed using the homeostasis model assessment-insulin resistance (HOMA-IR)...
October 2016: Biological Research for Nursing
https://www.readbyqxmd.com/read/27179014/association-of-the-genetic-polymorphisms-rrm1-756t-c-and-269c-a-with-cervical-neoplasia
#17
Ching-Wen Chang, Shun-Fa Yang, Po-Hui Wang, Hsiu-Ju Chang, Wen-Chi Liu, Hsiu-Ting Tsai
Cervical neoplasia is one of the most prevalent malignant neoplasms worldwide. Ribonucleotide reductase 1 (RRM1) is thought to play an essential role in modulating the development and progression of cervical neoplasia. Two novel genetic polymorphisms, RRM1 -756T>C and -269 C>A, are significantly correlated with RRM1 expression. Some epidemiological studies have demonstrated that genetic variants play a crucial role in susceptibility to cervical cancer. The present study aimed to identify the genetic polymorphisms RRM1 -756T>C and -269 C>A in patients with cervical neoplasia and healthy controls...
October 2016: Biological Research for Nursing
https://www.readbyqxmd.com/read/27179013/fatigue-and-oxidative-stress-in-children-undergoing-leukemia-treatment
#18
Cheryl Rodgers, Chelse Sanborn, Olga Taylor, Patricia Gundy, Alice Pasvogel, Ida M Ki Moore, Marilyn J Hockenberry
Fatigue is a frequent and distressing symptom in children undergoing leukemia treatment; however, little is known about factors influencing this symptom. Antioxidants such as glutathione can decrease symptom severity in adult oncology patients, but no study has evaluated antioxidants' effects on symptoms in pediatric oncology patients. This study describes fatigue patterns and associations of fatigue with antioxidants represented by reduced glutathione (GSH) and the reduced/oxidized glutathione (GSH/GSSG) ratio among children receiving leukemia treatment...
October 2016: Biological Research for Nursing
https://www.readbyqxmd.com/read/27142250/effects-of-intraventricular-methotrexate-on-neuronal-injury-and-gene-expression-in-a-rat-model-findings-from-an-exploratory-study
#19
Ida M Ki Moore, Carrie J Merkle, Howard Byrne, Adam Ross, Ashley M Hawkins, Sara S Ameli, David W Montgomery
Central nervous system (CNS)-directed treatment for acute lymphoblastic leukemia, used to prevent disease recurrence in the brain, is essential for survival. Systemic and intrathecal methotrexate, commonly used for CNS-directed treatment, have been associated with cognitive problems during and after treatment. The cortex, hippocampus, and caudate putamen, important brain regions for learning and memory, may be involved in methotrexate-induced brain injury. Objectives of this study were to (1) quantify neuronal degeneration in selected regions of the cortex, hippocampus, and caudate putamen and (2) measure changes in the expression of genes with known roles in oxidant defense, apoptosis/inflammation, and protection from injury...
October 2016: Biological Research for Nursing
https://www.readbyqxmd.com/read/27118148/the-intergenerational-impact-of-genetic-and-psychological-factors-on-blood-pressure-intergen-study-design-and-methods-for-complex-dna-analysis
#20
Jacquelyn Y Taylor, Michelle L Wright, Cindy A Crusto, Yan V Sun
The Intergenerational Impact of Genetic and Psychological Factors on Blood Pressure (InterGEN) study aims to delineate the independent and interaction effects of genomic (genetic and epigenetic) and psychological-environmental (maternally perceived racial discrimination, mental health, and parenting behavior) factors on blood pressure (BP) among African American mother-child dyads over time. The purpose of this article is to describe the two-step genetic and epigenetic approach that will be executed to explore Gene × Environment interactions on BP using a longitudinal cohort design...
October 2016: Biological Research for Nursing
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