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Prostate Cancer and Prostatic Diseases

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https://www.readbyqxmd.com/read/28485391/magnetic-resonance-imaging-targeted-transperineal-prostate-biopsy-a-local-anaesthetic-approach
#1
E J Bass, I A Donaldson, A Freeman, C Jameson, S Punwani, C Moore, M Arya, M Emberton, H U Ahmed
BACKGROUND: Despite high rates of disease misclassification and sepsis, the use of transrectal biopsy remains commonplace. Transperineal mapping biopsies mitigate these problems but carry increased cost and patient burden. Local anaesthetic, multiparametric magnetic resonance imaging (MRI)-targeted transperineal biopsy may offer an alternative. Here, we aim to determine the feasibility, tolerability and detection rates of clinically significant prostate cancer using a local anaesthetic, transperineal, MRI-targeted biopsy technique...
May 9, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28485390/the-survival-impact-of-neoadjuvant-hormonal-therapy-before-radical-prostatectomy-for-treatment-of-high-risk-prostate-cancer
#2
L Tosco, A Laenen, A Briganti, P Gontero, R J Karnes, M Albersen, P J Bastian, P Chlosta, F Claessens, F K Chun, W Everaerts, C Gratzke, M Graefen, B Kneitz, G Marchioro, R S Salas, B Tombal, T Van den Broeck, L Moris, A Battaglia, H van der Poel, J Walz, A Bossi, G De Meerleer, K Haustermans, H Van Poppel, M Spahn, S Joniau
BACKGROUND: Several randomized controlled trials assessed the outcomes of patients treated with neoadjuvant hormonal therapy (NHT) before radical prostatectomy (RP). The majority of them included mainly low and intermediate risk prostate cancer (PCa) without specifically assessing PCa-related death (PCRD). Thus, there is a lack of knowledge regarding a possible effect of NHT on PCRD in the high-risk PCa population. We aimed to analyze the effect of NHT on PCRD in a multicenter high-risk PCa population treated with RP, using a propensity-score adjustment...
May 9, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28462945/select-men-benefit-from-androgen-deprivation-therapy-delivered-with-salvage-radiation-therapy-after-prostatectomy
#3
E B Holliday, D A Kuban, L B Levy, Y Bolukbasi, P Master, S Choi, Q Nguyen, S E McGuire, U Mahmood, S J Frank, K E Hoffman
BACKGROUND: Which men benefit most from adding androgen deprivation therapy (ADT) to salvage radiation therapy (SRT) after prostatectomy has not clearly been defined; therefore, we evaluated the impact of ADT to SRT on failure-free survival (FFS) in men with a rising or persistent PSA after prostatectomy. METHODS: We identified 332 men who received SRT after prostatectomy from 1987 to 2010. Recursive partitioning analysis (RPA) identified favorable, intermediate and unfavorable groups based on the risk of failure after SRT alone...
May 2, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28462944/functional-outcomes-of-clinically-high-risk-prostate-cancer-patients-treated-with-robot-assisted-radical-prostatectomy-a-multi-institutional-analysis
#4
F Abdollah, D Dalela, A Sood, J Sammon, R Cho, L Nocera, M Diaz, W Jeong, J O Peabody, N Fossati, G Gandaglia, A Briganti, F Montorsi, M Menon
BACKGROUND: To ascertain 3-year urinary continence (UC) and sexual function (SF) recovery following robot-assisted radical prostatectomy (RARP) for clinically high-risk prostate cancer (PCa). METHODS: Retrospective analyses of a prospectively maintained database for 769 patients with D'Amico high-risk PCa undergoing RARP at two tertiary care centers in the United States and Europe between 2001 and 2014. The association between time since RARP and recovery of UC (defined as 0 pad/one safety liner per day) and SF (defined as sexual health inventory for men (SHIM) score ⩾17) was tested in separate preoperative and post-operative Cox-proportional hazards regression models...
May 2, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28462943/media-reporting-of-protect-a-disconnect-in-information-dissemination
#5
M E Westerman, B Bhindi, R Choo, M T Gettman, R J Karnes, L Klotz, S A Boorjian
BACKGROUND: Given the central role of the media in disseminating information to the public, we analyzed news coverage of the recent publication from ProtecT to assess views on treatment, the level of detail presented and degree of bias. METHODS: We applied a predefined search strategy to identify all news articles reporting on ProtecT within 30 days of its publication. Articles were independently assessed by two urologists and two lay persons using five-point Likert scales...
May 2, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28440325/multiparametric-mri-ultrasound-fusion-guided-biopsy-decreases-detection-of-indolent-cancer-in-african-american-men
#6
M Kongnyuy, M M Siddiqui, A K George, A Muthigi, A Sidana, M Maruf, B Turkbey, P L Choyke, B J Wood, P A Pinto
BACKGROUND: Analysis of systematic 12-core biopsies (SBx) has shown that African-American (AA) men tend to harbor higher risk prostate cancer (PCa) at presentation relative to other races. Multiparametric magnetic resonance imaging (mpMRI) and MRI-ultrasound fusion-guided biopsy (FBx) have been shown to diagnose more intermediate- and high-risk PCa in the general population; however, the efficacy in AA remains largely uncharacterized. We aim to evaluate the utility of FBx in an AA patient cohort...
April 25, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28440324/lutetium-177-labelled-anti-prostate-specific-membrane-antigen-antibody-and-ligands-for-the-treatment-of-metastatic-castrate-resistant-prostate-cancer-a-systematic-review-and-meta-analysis
#7
R J S Calopedos, V Chalasani, R Asher, L Emmett, H H Woo
BACKGROUND: Promising therapeutic results of the prostate-specific membrane antigen (PSMA) ligand have been shown when labelling with lutetium-177 ((177)Lu). We performed a systematic review and meta-analysis to assess the therapeutic response of (177)Lu-PSMA in the treatment of metastatic castration-resistant prostate cancer (mCRPC). METHODS: A systematic review was conducted using electronic databases up to December 2016. Two reviewers independently extracted data and assessed methodological quality...
April 25, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28440323/increased-dietary-and-circulating-lycopene-are-associated-with-reduced-prostate-cancer-risk-a-systematic-review-and-meta-analysis
#8
REVIEW
J L Rowles, K M Ranard, J W Smith, R An, J W Erdman
BACKGROUND: Prostate cancer (PCa) is the fifth leading cause of cancer-related deaths worldwide. Many epidemiological studies have investigated the association between prostate cancer and lycopene, however, results have been inconsistent. This study aims to determine the impact of dietary and circulating concentrations of lycopene on PCa risk and to investigate potential dose-response associations. METHODS: We conducted a systematic review and dose-response meta-analysis for the for the association between dietary and circulating lycopene and PCa risk...
April 25, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28440322/does-mpmri-improve-clinical-criteria-in-selecting-men-with-prostate-cancer-for-active-surveillance
#9
K J Tay, R T Gupta, J Holtz, R K Silverman, E Tsivian, A Schulman, J W Moul, T J Polascik
BACKGROUND: Active surveillance (AS) has excellent short to medium term outcomes in well-selected prostate cancer patients. Traditional biopsy-based selection criteria have been criticized for inaccurate determination of cancer grade and extent. We evaluated the incremental benefit of multiparametric magnetic resonance imaging (mpMRI) in patient selection using various AS criteria. METHODS: We retrospectively evaluated men who received mpMRI before radical prostatectomy between 2011 and 2014...
April 25, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28440321/association-of-comorbid-disease-burden-at-diagnosis-with-higher-tumor-grade-in-men-with-non-metastatic-prostate-cancer
#10
T J Daskivich, C J Dru, D Skarecky, T Ahlering, S J Freedland
BACKGROUND: While older age is associated with higher tumor grade, it is unknown whether comorbid disease burden has a similar, independent association. We sought to evaluate the impact of comorbid disease burden on tumor grade at diagnosis as indicated by biopsy Gleason score. METHODS: We conducted an observational cohort study of 1260 men newly diagnosed with non-metastatic prostate cancer from 1998 to 2004 at two Veterans Affairs Medical Centers. Multivariable ordinal and multinomial logistic regression were used to evaluate the association between Charlson Comorbidity Index score and biopsy Gleason score...
April 25, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28440320/a-review-of-pomegranate-in-prostate-cancer
#11
REVIEW
C J Paller, A Pantuck, M A Carducci
BACKGROUND: Preclinical studies showing that pomegranate juice and its components inhibit prostate cancer led to multiple clinical trials to determine whether pomegranate products could slow the growth of prostate cancer. This review summarizes the preclinical data and discusses the results of the clinical trials. METHODS: Trials targeted patients on active surveillance, neoadjuvant patients, patients with biochemical recurrence (BCR) following local therapy for prostate cancer, and patients with metastatic castration-resistant prostate cancer (mCRPC)...
April 25, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28417982/total-and-beverage-specific-alcohol-intake-and-the-risk-of-aggressive-prostate-cancer-a-case-control-study
#12
N P Papa, R J MacInnis, H Jayasekara, D R English, D Bolton, I D Davis, N Lawrentschuk, J L Millar, J Pedersen, G Severi, M C Southey, J L Hopper, G G Giles
BACKGROUND: Ethanol in alcoholic beverages is a known carcinogen, but its association with aggressive prostate cancer (APC) is uncertain. Recent studies have shown a modest increase in risk of APC associated with heavy alcohol intake while association for beverage types remain inconsistent. METHODS: Using a case-control design and self-administered questionnaire, we examined the association between APC (high grade and/or advanced stage) and frequency and quantity of alcohol intake 2 years prior to enrolment...
April 18, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28417981/reduced-prostate-cancer-risk-with-green-tea-and-epigallocatechin-3-gallate-intake-among-hong-kong-chinese-men
#13
P M Y Lee, C F Ng, Z M Liu, W M Ho, M K Lee, F Wang, H D Kan, Y H He, S S M Ng, S Y S Wong, L A Tse
BACKGROUND: In vitro and in vivo studies suggested that polyphenol epigallocatechin 3-gallate (EGCG) in tea may have anti-carcinogenic effect on prostate cells, but this protective effect has less been examined in epidemiology studies. We aimed to investigate the association between prostate cancer (PCA) risk and habitual green tea intake among Chinese men in Hong Kong; meanwhile, the relationship with EGCG was also explored. METHODS: We consecutively recruited 404 PCA cases and 395 controls from the same hospital who had complete data on habitual tea consumption, including green, oolong, black and pu'er tea...
April 18, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28417979/longitudinal-assessment-of-urinary-pca3-for-predicting-prostate-cancer-grade-reclassification-in-favorable-risk-men-during-active-surveillance
#14
J J Tosoian, H D Patel, M Mamawala, P Landis, S Wolf, D J Elliott, J I Epstein, H B Carter, A E Ross, L J Sokoll, C P Pavlovich
BACKGROUND: To assess the utility of urinary prostate cancer antigen 3 (PCA3) as both a one-time and longitudinal measure in men on active surveillance (AS). METHODS: The Johns Hopkins AS program monitors men with favorable-risk prostate cancer with serial PSA, digital rectal examination (DRE), prostate magnetic resonance imaging and prostate biopsy. Since 2007, post-DRE urinary specimens have also been routinely obtained. Men with multiple PCA3 measures obtained over ⩾3 years of monitoring were included...
April 18, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28398296/trends-in-the-use-of-radiation-therapy-for-stage-iia-prostate-cancer-from-2004-to-2013-a-retrospective-analysis-using-the-national-cancer-database
#15
T Malouff, N W Mathy, S Marsh, R W Walters, P T Silberstein
BACKGROUND: Recent studies have shown a decrease in the overall use of radiation therapy in the treatment of prostate cancer over the past several decades, as well as a more conservative overall treatment approach. We aim to determine whether this trend continued from 2004 to 2013, and to determine whether there were changes in utilization for various types of radiation. METHODS: We conducted this retrospective study using the National Cancer Database. We identified 706 877 patients with sufficient treatment information diagnosed with stage IIA prostate cancer between 2004 and 2013...
April 11, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28398294/long-term-allopurinol-use-decreases-the-risk-of-prostate-cancer-in-patients-with-gout-a-population-based-study
#16
H-J Shih, M-C Kao, P-S Tsai, Y-C Fan, C-J Huang
BACKGROUND: Clinical observations indicated an increased risk of developing prostate cancer in gout patients. Chronic inflammation is postulated to be one crucial mechanism for prostate carcinogenesis. Allopurinol, a widely used antigout agent, possesses potent anti-inflammation capacity. We elucidated whether allopurinol decreases the risk of prostate cancer in gout patients. METHODS: We analyzed data retrieved from Taiwan National Health Insurance Database between January 2000 and December 2012...
April 11, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28374743/extracellular-vesicles-for-liquid-biopsy-in-prostate-cancer-where-are-we-and-where-are-we-headed
#17
REVIEW
V R Minciacchi, A Zijlstra, M A Rubin, D Di Vizio
BACKGROUND: Extracellular vesicles (EVs) are a heterogeneous class of lipid bound particles shed by any cell in the body in physiological and pathological conditions. EVs play critical functions in intercellular communication. EVs can actively travel in intercellular matrices and eventually reach the circulation. They can also be released directly in biological fluids where they appear to be stable. Because the molecular content of EVs reflects the composition of the cell of origin, they have recently emerged as a promising source of biomarkers in a number of diseases...
April 4, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28349981/impact-of-urologists-ownership-of-radiation-equipment-in-the-treatment-of-prostate-cancer
#18
S B Williams, J Huo, B F Chapin, B D Smith, K E Hoffman
BACKGROUND: Physician practices that offer ancillary medical services may refer their patients for such services, a process known as self-referral. We wanted to evaluate how utilization and cost of care differ for men diagnosed with prostate cancer in a self-referral practice (SRP) compared to a traditional urologic practice. METHODS: A total of 17 982 men aged 66 years and older diagnosed with localized prostate cancer from 2006 to 2009 were identified from the Texas Cancer Registry...
March 28, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28349980/celastrol-an-active-constituent-of-the-tcm-plant-tripterygium-wilfordii-hook-f-inhibits-prostate-cancer-bone-metastasis
#19
K Kuchta, Y Xiang, S Huang, Y Tang, X Peng, X Wang, Y Zhu, J Li, J Xu, Z Lin, T Pan
No abstract text is available yet for this article.
March 28, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28349979/androgen-deprivation-therapy-for-prostate-cancer-and-dementia-risk-a-systematic-review-and-meta-analysis
#20
REVIEW
K T Nead, S Sinha, P L Nguyen
BACKGROUND: Androgen deprivation therapy (ADT) to treat prostate cancer may be associated with an increased risk of dementia, but existing studies have shown conflicting results. Here we synthesize the literature on the association of ADT for the treatment of prostate cancer with dementia risk. METHODS: We conducted a systematic review of articles reporting the outcome of dementia among individuals with prostate cancer in those exposed to ADT versus a lesser-exposed comparison group (for example, ADT versus no-ADT; continuous versus intermittent ADT) using PubMed (1966-present), Web of Science (1945-present), Embase (1966-present) and PsycINFO (1806-present)...
March 28, 2017: Prostate Cancer and Prostatic Diseases
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