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Prostate Cancer and Prostatic Diseases

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https://www.readbyqxmd.com/read/27897172/adaptation-and-external-validation-of-the-european-randomised-study-of-screening-for-prostate-cancer-risk-calculator-for-the-chinese-population
#1
P K Chiu, M J Roobol, D Nieboer, J Y Teoh, S K Yuen, S M Hou, M K Yiu, C F Ng
BACKGROUND: To adapt the well-performing European Randomized Study of Screening for Prostate Cancer (ERSPC) risk calculator to the Chinese setting and perform an external validation. METHODS: The original ERSPC risk calculator 3 (RC3) for prostate cancer (PCa) and high-grade PCa (HGPCa) was applied to a development cohort of 3006 previously unscreened Hong Kong Chinese men with initial transrectal biopsies performed from 1997 to 2015, age 50-80 years, PSA 0.4-50 ng ml(-1) and prostate volume 10-150 ml...
November 29, 2016: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/27845330/the-prognostic-role-of-tertiary-gleason-pattern-5-in-a-contemporary-grading-system-for-prostate-cancer
#2
W S Jang, C Y Yoon, M S Kim, D H Kang, Y J Kang, W S Jeong, M J Abalajon, W S Ham, Y D Choi
BACKGROUND: Recently, a new prostate cancer (PC) grading system has been introduced, where Gleason score (GS) 7 (3+4) and GS 7 (4+3) are categorized into two separate groups. However, GS 7 with tertiary Gleason pattern 5 (TGP5) was not incorporated in the new grading system. In the present study, we validated the prognostic role of TGP5 in the new classification. METHODS: We retrospectively reviewed the records of 1396 patients with localized GS 6-8 PC (pT2-3N0M0) who underwent radical prostatectomy at our institution between 2005 and 2014...
November 15, 2016: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/27824043/duration-of-the-anti-androgen-in-men-undergoing-6-months-of-an-lhrh-agonist-and-radiation-therapy-for-unfavorable-risk-prostate-cancer-and-the-risk-of-death
#3
N N Sanford, M-H Chen, M Loffredo, A Renshaw, P W Kantoff, A V D'Amico
BACKGROUND: Whether adding a first-generation anti-androgen (AA) to a luteinizing hormone-releasing hormone agonist in the radiotherapeutic management of unfavorable-risk prostate cancer (PC) reduces the risk of all-cause and PC-specific mortality (ACM and PCSM) among men within differing comorbidity subgroups is unknown. METHODS: Between 1995 and 2001, 206 men with unfavorable-risk PC were enrolled in a randomized trial comparing radiation with or without 6 months of androgen-deprivation therapy (ADT)...
November 8, 2016: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/27824042/the-role-of-salvage-extended-lymph-node-dissection-in-patients-with-rising-psa-and-pet-ct-scan-detected-nodal-recurrence-of-prostate-cancer
#4
D Porres, D Pfister, A Thissen, T H Kuru, V Zugor, R Buettner, R Knuechel, F A Verburg, A Heidenreich
BACKGROUND: Non-prostatic bed recurrence of prostate cancer (PCa) is usually treated with androgen deprivation therapy (ADT). We analyzed the impact of salvage extended lymph node dissection (sLND) on cancer control in patients with rising PSA and lymph node (LN) metastases. METHODS: Between 2009 and 2016 we performed sLND in 87 patients with biochemical recurrence (BCR) and positive LNs on (18)FEC and (68)Ga-PSMA positron emission tomography/X-ray computer tomography (PET/CT) after primary treatment (PT) of PCa...
November 8, 2016: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/27801901/correlation-of-b7-h3-with-androgen-receptor-immune-pathways-and-poor-outcome-in-prostate-cancer-an-expression-based-analysis
#5
B Benzon, S G Zhao, M C Haffner, M Takhar, N Erho, K Yousefi, P Hurley, J L Bishop, J Tosoian, K Ghabili, M Alshalalfa, S Glavaris, B W Simons, P Tran, E Davicioni, R J Karnes, K Boudadi, E S Antonarakis, E M Schaeffer, C G Drake, F Feng, A E Ross
BACKGROUND: B7-H3 (CD276), part of the B7 superfamily of immune checkpoint molecules, has been shown to have an immunomodulatory role. Its regulation, receptor and mechanism of action remain unclear. B7-H3 protein expression correlates with prostate cancer outcomes, and humanized monoclonal antibodies (that is, enoblituzumab) are currently being investigated for therapeutic use. Here we used genomic expression data to examine the relationship between B7-H3 mRNA expression and prostate cancer...
November 1, 2016: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/27801900/active-surveillance-for-intermediate-risk-prostate-cancer
#6
REVIEW
M A Dall'Era, L Klotz
BACKGROUND: Utilization of active surveillance (AS) for prostate cancer is increasing. Optimal selection criteria for this approach are undefined and questions remain on how best to expand inclusion beyond typical men with very low- or low-risk disease. We sought to review the current experience with AS for men with intermediate-risk featuresMethods:PubMed was queried for all relevant original publications describing outcomes for men with prostate cancer managed with AS. Outcomes for patients with intermediate-risk features as defined by the primary investigators were studied when available and compared with similar risk men undergoing immediate treatment...
November 1, 2016: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/27779203/socs1-inhibits-migration-and-invasion-of-prostate-cancer-cells-attenuates-tumor-growth-and-modulates-the-tumor-stroma
#7
A Villalobos-Hernandez, D Bobbala, R Kandhi, M G M Khan, M Mayhue, C M Dubois, G Ferbeyre, C Saucier, S Ramanathan, S Ilangumaran
BACKGROUND: The suppressor of cytokine signaling 1 (SOCS1) gene is repressed in prostate cancer (PCa) by epigenetic silencing and microRNA miR30d. Increased expression of the SOCS1-targeting miR30d correlates with higher biochemical recurrence, suggesting a tumor suppressor role of SOCS1 in PCa, but the underlying mechanisms are unclear. We have shown that SOCS1 inhibits MET receptor kinase signaling, a key oncogenic pathway in cancer progression. Here we evaluated the role of SOCS1 in attenuating MET signaling in PCa cells and tumor growth in vivo...
October 25, 2016: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/27779202/the-impact-of-local-treatment-of-the-primary-tumor-site-in-node-positive-and-metastatic-prostate-cancer-patients
#8
M Moschini, F Soria, A Briganti, S F Shariat
BACKGROUND: Surgical treatment of the primary tumor in patients with metastatic prostate cancer (mPCa) is gaining traction. We discuss the biological rational and the existing literature on this approach. METHODS: We reviewed the literature regarding surgical management of advanced and mPCa disease. RESULTS: Surgical removal of the primary tumor despite metastases is becoming a standard in an increasing number of malignancies. Basic science data support the use of surgical removal of the prostate in metastatic PCa...
October 25, 2016: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/27725729/does-prostate-volume-correlate-with-vitamin-d-deficiency-among-men-undergoing-prostate-biopsy
#9
A B Murphy, Y A Nyame, K Batai, R Kalu, A Khan, P Gogana, M Dixon, V Macias, A Kajdacsy-Balla, C M P Hollowell, W J Catalona, R Kittles
OBJECTIVES: Recent studies demonstrate vitamin D is inversely correlated with BPH and prostate cancer (PCa) incidence. We aim to clarify the associations of vitamin D with prostate volume. METHODS: This is an observational study investigating the associations of serum PSA, PSA density and prostate volume with serum 25-hydroxyvitamin D (25-OH D) in PCa patients and men with negative biopsies seen in outpatient urology clinics in Chicago, IL, USA. There were 571 men (40-79 years old) with elevated PSA or abnormal digital rectal examination with available prostate volume recorded from initial biopsy...
October 11, 2016: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/27698440/long-term-oncological-outcomes-of-apical-positive-surgical-margins-at-radical-prostatectomy-in-the-shared-equal-access-regional-cancer-hospital-cohort
#10
H Wadhwa, M K Terris, W J Aronson, C J Kane, C L Amling, M R Cooperberg, S J Freedland, M R Abern
BACKGROUND: Approximately 29-38% of all positive surgical margins (PSMs) at radical prostatectomy (RP) involve the apex. The prognostic significance of apical PSM remains unclear. We therefore compared the long-term oncologic outcomes of men with apical PSMs to those with negative PSMs, apical and other PSMs, and other PSMs at RP. METHODS: The SEARCH (Shared Equal Access Regional Cancer Hospital) database was used to identify 4031 men with prostate cancer (PCa) managed with RP with complete pathologic grade and stage data...
October 4, 2016: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/27698439/obesity-and-prostate-cancer-specific-mortality-after-radical-prostatectomy-results-from-the-shared-equal-access-regional-cancer-hospital-search-database
#11
A C Vidal, L E Howard, S X Sun, M R Cooperberg, C J Kane, W J Aronson, M K Terris, C L Amling, S J Freedland
BACKGROUND: At the population level, obesity is associated with prostate cancer (PC) mortality. However, few studies analyzed the associations between obesity and long-term PC-specific outcomes after initial treatment. METHODS: We conducted a retrospective analysis of 4268 radical prostatectomy patients within the Shared Equal Access Regional Cancer Hospital (SEARCH) database. Cox models accounting for known risk factors were used to examine the associations between body mass index (BMI) and PC-specific mortality (PCSM; primary outcome)...
October 4, 2016: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/27670718/impact-of-single-agent-daily-prednisone-on-outcomes-in-men-with-metastatic-castration-resistant-prostate-cancer
#12
G Sonpavde, G R Pond, A J Templeton, E D Kwon, J S De Bono
BACKGROUND: Despite palliative benefits and PSA responses, the objective clinical impact of daily oral prednisone (P) for metastatic castration-resistant prostate cancer (mCRPC) is unknown. We performed a pooled analysis of control arms of randomized trials that either did or did not administer single-agent P to evaluate its impact on overall survival (OS) and toxicities. METHODS: Individual patient data from control arms of randomized trials of men with mCRPC who received placebo or P+placebo post docetaxel were eligible for analysis...
September 27, 2016: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/27670717/a-meta-analysis-of-cardiovascular-events-in-intermittent-androgen-deprivation-therapy-versus-continuous-androgen-deprivation-therapy-for-prostate-cancer-patients
#13
C Jin, Y Fan, Y Meng, C Shen, Y Wang, S Hu, C Cui, T Xu, W Yu, J Jin
No abstract text is available yet for this article.
September 27, 2016: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/27645128/role-of-oatp-transporters-in-steroid-uptake-by-prostate-cancer-cells-in-vivo
#14
S M Green, A Kaipainen, K Bullock, A Zhang, J M Lucas, C Matson, W A Banks, E A Mostaghel
BACKGROUND: Epidemiologic and in vitro studies suggest that SLCO-encoded organic anion transporting polypeptide (OATP) transporters influence the response of prostate cancer (PCa) to androgen deprivation by altering intratumor androgens. We have previously shown that castration-resistant metastases express multiple SLCO transporters at significantly higher levels than primary PCa, suggesting that OATP-mediated steroid transport is biologically relevant in advanced disease. However, whether OATP-mediated steroid transport can actually modify prostate tumor androgen levels in vivo has never been demonstrated...
September 20, 2016: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/27618951/increasing-use-of-radical-prostatectomy-for-locally-advanced-prostate-cancer-in-the-usa-and-germany-a-comparative-population-based-study
#15
B Hager, K Kraywinkel, B Keck, A Katalinic, M Meyer, S R Zeissig, R Scheufele, M P Wirth, J Huber
BACKGROUND: Current guidelines do not recommend a preferred treatment modality for locally advanced prostate cancer. The aim of the study was to compare treatment patterns found in the USA and Germany and to analyze possible trends over time. METHODS: We compared 'Surveillance Epidemiology and End Results' (SEER) data (USA) with reports from four German federal epidemiological cancer registries (Eastern Germany, Bavaria, Rhineland-Palatinate, Schleswig-Holstein), both from 2004 to 2012...
September 13, 2016: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/27618950/the-very-high-risk-prostate-cancer-a-contemporary-update
#16
R Mano, J Eastham, O Yossepowitch
BACKGROUND: Treatment of high-risk prostate cancer has evolved considerably over the past two decades, yet patients with very-high-risk features may still experience poor outcome despite aggressive therapy. We review the contemporary literature focusing on current definitions, role of modern imaging and treatment alternatives in very-high-risk prostate cancer. METHODS: We searched the MEDLINE database for all clinical trials or practice guidelines published in English between 2000 and 2016, with the following search terms: 'prostatic neoplasms' (MeSH Terms) AND ('high risk' (keyword) OR 'locally advanced' (keyword) OR 'node positive' (keyword))...
September 13, 2016: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/27595916/saturated-fat-intake-and-prostate-cancer-aggressiveness-results-from-the-population-based-north-carolina-louisiana-prostate-cancer-project
#17
E H Allott, L Arab, L J Su, L Farnan, E T H Fontham, J L Mohler, J T Bensen, S E Steck
BACKGROUND: Epidemiologic and laboratory evidence supports a role for cholesterol in prostate cancer (PC). Dietary saturated fat content impacts serum cholesterol levels. However, epidemiologic associations between saturated fat and PC aggressiveness are inconsistent. We hypothesized that high saturated fat intake would be associated with increased PC aggressiveness, and that statin use would modify this association. METHODS: Of 1854 PC cases in the North Carolina-Louisiana PC Project, 321 (17%) were classified as high aggressive (Gleason sum ⩾8, PSA>20 ng ml(-1), or Gleason sum ⩾7 and clinical stage T3-4) or low/intermediate aggressive (all other cases)...
September 6, 2016: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/27595915/a-meta-analysis-of-cardiovascular-events-in-intermittent-androgen-deprivation-therapy-versus-continuous-androgen-deprivation-therapy-for-prostate-cancer-patients
#18
C Jin, Y Fan, Y Meng, C Shen, Y Wang, S Hu, C Cui, T Xu, W Yu, J Jin
BACKGROUND: Androgen-deprivation therapy (ADT) is the standard treatment for advanced and recurrent prostate cancer but it has been shown to cause adverse effects on the cardiovascular system. Intermittent androgen deprivation has been studied as an alternative therapy. To conduct a meta-analysis comparing the incidence of cardiovascular events in patients with prostate cancer receiving intermittent (IADT) versus continuous ADT (CADT). METHODS: We searched Cochrane CENTRAL, PubMed/Medline, Embase, Web of Science, The National Cancer Institute Clinical Trials and The Clinical Trials Register of Trials Central, and Google Scholar from inception of each database through February 2016...
September 6, 2016: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/27431496/increasing-incidence-of-metastatic-prostate-cancer-in-the-united-states-2004-2013
#19
A B Weiner, R S Matulewicz, S E Eggener, E M Schaeffer
BACKGROUND: Changes in prostate cancer screening practices in the United States have led to recent declines in overall incidence, but it is unknown whether relaxed screening has led to changes in the incidence of advanced and metastatic prostate cancer at diagnosis. METHODS: We identified all men diagnosed with prostate cancer in the National Cancer Data Base (2004-2013) at 1089 different health-care facilities in the United States. Joinpoint regressions were used to model annual percentage changes (APCs) in the incidence of prostate cancer based on stage relative to that of 2004...
December 2016: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/27349496/a-review-of-clinical-effects-associated-with-metabolic-syndrome-and-exercise-in-prostate-cancer-patients
#20
REVIEW
J L Kiwata, T B Dorff, E T Schroeder, M E Gross, C M Dieli-Conwright
Androgen deprivation therapy (ADT), a primary treatment for locally advanced or metastatic prostate cancer, is associated with the adverse effects on numerous physiologic parameters, including alterations in cardiometabolic variables that overlap with components of the metabolic syndrome (MetS). As MetS is an established risk factor for cardiovascular mortality and treatment for prostate cancer has been associated with the development of MetS, interventions targeting cardiometabolic factors have been investigated in prostate cancer patients to attenuate the detrimental effects of ADT...
December 2016: Prostate Cancer and Prostatic Diseases
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