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Prostate Cancer and Prostatic Diseases

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https://www.readbyqxmd.com/read/29743538/which-technology-to-select-for-primary-focal-treatment-of-prostate-cancer-european-section-of-urotechnology-esut-position-statement
#1
REVIEW
Roman Ganzer, Vinodh Kumar Adithyaa Arthanareeswaran, Hashim U Ahmed, Andrea Cestari, Pascal Rischmann, Georg Salomon, Dogu Teber, Evangelos Liatsikos, Jens-Uwe Stolzenburg, Eric Barret
BACKGROUND: With growing interest in focal therapy (FT) of prostate cancer (PCa) there is an increasing armamentarium of treatment modalities including high-intensity focused ultrasound (HIFU), cryotherapy, focal laser ablation (FLA), irreversible electroporation (IRE), vascular targeted photodynamic therapy (VTP), focal brachytherapy (FBT) and stereotactic ablative radiotherapy (SABR). Currently there are no clear recommendations as to which of these technologies are appropriate for individual patient characteristics...
May 9, 2018: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29720722/development-of-comorbidities-in-men-with-prostate-cancer-treated-with-androgen-deprivation-therapy-an-australian-population-based-cohort-study
#2
Huah Shin Ng, Bogda Koczwara, David Roder, Agnes Vitry
BACKGROUND: The increasing use of androgen deprivation therapy has prompted further evaluation of its potential adverse effects as the treatment may exacerbate or increase the risk of developing new comorbid diseases. This study aims to assess the patterns of comorbidities among Australian men with prostate cancer treated with androgen deprivation therapy. METHODS: Pharmaceutical Benefits Scheme (PBS) 10% data between 1 January 2003 and 31 December 2014 was utilised in this retrospective cohort study...
May 2, 2018: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29700389/does-the-association-of-prostate-cancer-with-night-shift-work-differ-according-to-rotating-vs-fixed-schedule-a-systematic-review-and-meta-analysis
#3
REVIEW
Jennifer Mancio, Cátia Leal, Marta Ferreira, Pedro Norton, Nuno Lunet
BACKGROUND: Recent studies suggested that the relation between night-shift work and prostate cancer may differ between rotating and fixed schedules. OBJECTIVES: We aimed to quantify the independent association between night-shift work and prostate cancer, for rotating and fixed schedules. METHODS: We searched MEDLINE for studies assessing the association of night-shift work, by rotating or fixed schedules, with prostate cancer. We computed summary relative risk (RR) estimates with 95% confidence intervals (95% CI) using the inverse variance method and quantified heterogeneity using the I2 statistic...
April 27, 2018: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29700388/changes-in-cerebral-metabolic-activity-in-men-undergoing-androgen-deprivation-therapy-for-non-metastatic-prostate-cancer
#4
M M Cherrier, D J Cross, C S Higano, S Minoshima
OBJECTIVE: Androgen deprivation therapy (ADT) is a common treatment option for men with biochemical relapse from prostate cancer. ADT is associated with changes in mood, cognition, and quality of life, and most recently with increased risk for Alzheimer's disease (AD). This study examined changes in brain metabolism using positron emission tomography (PET) in men undergoing intermittent ADT. METHODS: Nine men with prostate cancer and a rising PSA (biochemical recurrence) without evidence of metastases were treated with intermittent ADT consisting of 9 months of complete androgen blockade achieved with combined leuprolide acetate and flutamide...
April 27, 2018: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29686417/prostatic-inflammation-a-potential-treatment-target-for-male-luts-due-to-benign-prostatic-obstruction
#5
REVIEW
M Samarinas, M Gacci, A de la Taille, S Gravas
BACKGROUND: The purpose of this narrative review is to evaluate the role of prostatic inflammation as a treatment target for lower urinary tract symptoms (LUTS) due to benign prostatic obstruction (BPO) and provide an update on the available therapies. METHODS: An extensive literature search was conducted for studies on established and investigational treatments with anti-inflammatory mechanism of action that has been assessed for the management of male LUTS due to BPO...
April 24, 2018: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29686416/reply-to-phase-ii-prospective-randomized-trial-of-weight-loss-prior-to-radical-prostatectomy
#6
LETTER
W Demark-Wahnefried, S Rais-Bahrami, R A Desmond, J B Gordetsky, M Azrad, A D Frugé, E S Yang, L A Norian, W E Grizzle
No abstract text is available yet for this article.
April 24, 2018: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29520019/hypofractionated-simultaneous-integrated-boost-imrt-sib-with-pelvic-nodal-irradiation-and-concurrent-androgen-deprivation-therapy-for-high-risk-prostate-cancer-results-of-a-prospective-phase-ii-trial
#7
Alessandro Magli, Eugenia Moretti, Annarita Tullio, Gianluca Giannarini, Fabrizio Tonetto, Mauro Urpis, Margherita Crespi, Claudio Foti, Agnese Prisco, Margherita Polsinelli, Gioacchino De Giorgi, Giulia Bravo, Paolo Scalchi, Marco Trovò
OBJECTIVE: The approach for treating high-risk prostate cancer still presents different unresolved issues. We report the safety and efficacy of a radiation therapy strategy based on the combination of moderate hypofractioned simultaneous integrated boost (SIB) and Image Guidance. MATERIALS AND METHODS: In this phase II trial of patients with high-risk prostate cancer, Image Guided SIB-IMRT plans (Simultaneous Intensity Modulated - Intensity Modulated Radiotherapy) were delivered between 2009 and 2012...
March 8, 2018: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29487398/fosfomycin-vs-quinolone-based-antibiotic-prophylaxis-for-transrectal-ultrasound-guided-biopsy-of-the-prostate-a-systematic-review-and-meta-analysis
#8
REVIEW
Jurate Noreikaite, Patrick Jones, John Fitzpatrick, Ramachandran Amitharaj, Amelia Pietropaolo, Nikhil Vasdev, David Chadwick, Bhaskar K Somani, Bhavan Prasad Rai
BACKGROUND: Infection-related complications secondary to quinolone resistance have been on the rise following transrectal ultrasound-guided biopsy of the prostate (TRUSBP). The aim of this review was to compare the efficacy of fosfomycin with quinolone-based antibiotic prophylaxis for TRUSBP. METHODS: A systematic review in line with the preferred reporting items for systematic reviews and meta-analyses (PRISMA) and Cochrane guidelines was conducted. All studies comparing fosfomycin vs...
February 27, 2018: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29487397/contemporary-approach-to-predict-early-biochemical-recurrence-after-radical-prostatectomy-update-of-the-walz-nomogram
#9
Raisa S Pompe, Marco Bandini, Felix Preisser, Michele Marchioni, Emanuele Zaffuto, Zhe Tian, Georg Salomon, Thorsten Schlomm, Hartwig Huland, Markus Graefen, Derya Tilki, Shahrokh F Shariat, Pierre I Karakiewicz
BACKGROUND: Early biochemical recurrence (eBCR) after radical prostatectomy (RP) heralds poor oncological outcomes and may be prevented with adjuvant radiation (aRT). METHODS: We developed a contemporary eBCR nomogram in 13 797 RP patients from Hamburg (2005-2016) and externally validated it in 5952 RP patients from Vienna. Receiver operating characteristics-derived area under the curve (AUC), Heagerty's C-index, and decision curve analysis (DCA) were used to quantify model accuracy and to compare the current tool with the Walz nomogram, the online Memorial Sloan Kettering Cancer Center (MSKCC) nomogram and the post-surgical Cancer of the Prostate Risk Assesment (CAPRA-S)...
February 27, 2018: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29556048/combining-immune-check-point-blockade-and-cryoablation-in-an-immunocompetent-hormone-sensitive-murine-model-of-prostate-cancer
#10
Benjamin Benzon, Stephanie A Glavaris, Brian W Simons, Robert M Hughes, Kamyar Ghabili, Patrick Mullane, Rebecca Miller, Katriana Nugent, Brian Shinder, Jeffrey Tosoian, Ephraim J Fuchs, Phuoc T Tran, Paula J Hurley, Milena Vuica-Ross, Edward M Schaeffer, Charles G Drake, Ashley E Ross
BACKGROUND: Prostate cancer remains the second leading cause of cancer related death in men. Immune check point blocking antibodies have revolutionized treatment of multiple solid tumors, but results in prostate cancer remain marginal. Previous reports have suggested that local therapies, in particular cryoablation might increase tumor immunogenicity. In this work, we examine potential synergism between tumor cryoabalation and check point blocking antibodies. METHODS: FVB/NJ mice were injected subcutaneously into each flank with either 1 × 106 or 0...
April 2018: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29472629/indication-to-pelvic-lymph-nodes-dissection-for-prostate-cancer-the-role-of-multiparametric-magnetic-resonance-imaging-when-the-risk-of-lymph-nodes-invasion-according-to-briganti-updated-nomogram-is-5
#11
Francesco Porpiglia, Matteo Manfredi, Fabrizio Mele, Riccardo Bertolo, Enrico Bollito, Dario Gned, Agostino De Pascale, Filippo Russo, Roberto Passera, Cristian Fiori, Stefano De Luca
BACKGROUND: The Briganti updated nomogram (BN) is the most popular predictive model aiming to predict the presence of lymph node invasion (LNI) in patients with prostate cancer (PCa), but it lacks information obtained by preoperative imaging. The primary aim of the study was to evaluate the role of multiparametric prostate magnetic resonance imaging (mp-MRI) in the indication to perform pelvic lymph nodes dissection (PLND) or not in patients with risk of LNI according to BN below 5%. METHODS: Since March 2012 and September 2016, 310 patients who underwent a preoperative mp-MRI for staging purpose and subsequent robot-assisted extended PLND (RAEPLND) were retrospectively evaluated...
April 2018: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29339807/overexpression-of-%C3%AE-1-6-fucosyltransferase-in-the-development-of-castration-resistant-prostate-cancer-cells
#12
Naseruddin Höti, Shuang Yang, Yingwei Hu, Punit Shah, Michael C Haffner, Hui Zhang
Glycosylation is recognized as one of the most common modifications on proteins. Recent studies have shown that aberrant expression of α (1,6) fucosyltransferase (FUT8), which catalyzes the transfer of fucose from GDP-fucose to core-GlcNAc of the N-linked glycoproteins, modulates cellular behavior that could lead to the development of aggressive prostate cancer. While the relationship between the abnormal expression of FUT8 and glycoprotein fucosylation in different prostate cancer cells has been demonstrated, there is no evidence that shows dysregulated fucosylation might be involved in prostate cancer progression from androgen-dependent to castration-resistant prostate cancer...
April 2018: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29339806/tumor-characteristics-treatments-and-oncological-outcomes-of-prostate-cancer-in-men-aged-%C3%A2-50-years-a-population-based-study
#13
Raisa S Pompe, Ariane Smith, Marco Bandini, Michele Marchioni, Tristan Martel, Felix Preisser, Sami-Ramzi Leyh-Bannurah, Jonas Schiffmann, Fred Saad, Hartwig Huland, Markus Graefen, Shahrokh F Shariat, Derya Tilki, Pierre I Karakiewicz
BACKGROUND: To examine clinical characteristics, treatment modalities and oncological outcomes of prostate cancer (PCa) according to young (≤50) vs. old age. METHODS: Of 407,599 men with primary adenocarcinoma of the prostate within the Surveillance, Epidemiology and End Results (SEER)-database (2004 to 2013), 18,387 were aged ≤50 years (4.5%). Time trends, cumulative incidence, and competing risks regression (CRR) analyses tested for differences between young and old patients...
April 2018: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29259293/prostate-specific-antigen-psa-density-in-the-diagnostic-algorithm-of-prostate-cancer
#14
Tobias Nordström, Olof Akre, Markus Aly, Henrik Grönberg, Martin Eklund
BACKGROUND: Screening for prostate cancer using prostate-specific antigen (PSA) alone leads to un-necessary biopsying and overdiagnosis. PSA density is easily accessible, but early evidence on its use for biopsy decisions was conflicting and use of PSA density is not commonly recommended in guidelines. METHODS: We analyzed biopsy outcomes in 5291 men in the population-based STHLM3 study with PSA ≥ 3 ng/ml and ultrasound-guided prostate volume measurements by using percentages and regression models...
April 2018: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29317772/processed-and-raw-tomato-consumption-and-risk-of-prostate-cancer-a-systematic-review-and-dose-response-meta-analysis
#15
REVIEW
Joe L Rowles, Katherine M Ranard, Catherine C Applegate, Sookyoung Jeon, Ruopeng An, John W Erdman
BACKGROUND: Prostate cancer (PCa) is the second most frequently diagnosed cancer among men worldwide. Many epidemiological studies have found an inverse association between increased tomato consumption and PCa risk. This study aims to determine the associations between consumption of various types of tomato products and PCa risk and to investigate potential dose-response relationships. METHODS: We conducted a systematic review and dose-response meta-analysis of dietary tomato in relation to PCa...
January 9, 2018: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29302046/p53-status-in-the-primary-tumor-predicts-efficacy-of-subsequent-abiraterone-and-enzalutamide-in-castration-resistant-prostate-cancer
#16
Benjamin L Maughan, Liana B Guedes, Kenneth Boucher, Gaurav Rajoria, Zach Liu, Szczepan Klimek, Roberto Zoino, Emmanuel S Antonarakis, Tamara L Lotan
BACKGROUND: We tested whether tissue-based analysis of p53 and PTEN genomic status in primary tumors is predictive for subsequent sensitivity to abiraterone and enzalutamide in castration-resistant prostate cancer (CRPC). METHODS: We performed a retrospective analysis of 309 consecutive patients with CRPC treated with abiraterone or enzalutamide. Of these, 101 men (33%) had available primary tumor tissue for analysis. We screened for deleterious TP53 missense mutations and PTEN deletions using genetically validated immunohistochemical assays for nuclear accumulation of p53 protein and PTEN protein loss, with sequencing confirmation of TP53 mutations in a subset...
January 4, 2018: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29298992/germline-variants-in-il4-mgmt-and-akt1-are-associated-with-prostate-cancer-specific-mortality-an-analysis-of-12-082-prostate-cancer-cases
#17
L M FitzGerald, S Zhao, A Leonardson, M S Geybels, S Kolb, D W Lin, J L Wright, R Eeles, Z Kote-Jarai, K Govindasami, G G Giles, M C Southey, J Schleutker, T L Tammela, C Sipeky, K L Penney, M J Stampfer, H Gronberg, F Wiklund, P Stattin, J Hugosson, D M Karyadi, E A Ostrander, Z Feng, J L Stanford
BACKGROUND: Prostate cancer (PCa) is a leading cause of mortality and genetic factors can influence tumour aggressiveness. Several germline variants have been associated with PCa-specific mortality (PCSM), but further replication evidence is needed. METHODS: Twenty-two previously identified PCSM-associated genetic variants were genotyped in seven PCa cohorts (12,082 patients; 1544 PCa deaths). For each cohort, Cox proportional hazards models were used to calculate hazard ratios and 95% confidence intervals for risk of PCSM associated with each variant...
January 3, 2018: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29298991/current-approaches-to-incorporation-of-radium-223-in-clinical-practice
#18
REVIEW
Chris Parker, Axel Heidenreich, Sten Nilsson, Neal Shore
BACKGROUND: Treatment options for metastatic castration-resistant prostate cancer (mCRPC) have expanded in recent years and include cytotoxic agents (e.g., docetaxel and cabazitaxel), immunotherapy (e.g., sipuleucel-T), oral hormonal therapies targeting the androgen receptor axis (e.g., enzalutamide and abiraterone), and targeted alpha therapy (e.g., radium-223 dichloride (radium-223)). Although treatment guidelines have been updated to reflect the availability of new agents, it is not easy to apply them in daily clinical practice because recommendations vary depending on patient comorbidities and disease characteristics...
January 3, 2018: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29296018/prostate-cancer-radiation-and-urethral-strictures-a-systematic-review-and-meta-analysis
#19
REVIEW
Mohannad A Awad, Thomas W Gaither, E Charles Osterberg, Gregory P Murphy, Nima Baradaran, Benjamin N Breyer
BACKGROUND: We performed a systematic review and meta-analysis to determine the prevalence and predictors of urethral stricture development post radiation therapy (RT) for prostate cancer (PCa). METHODS: Published articles in PubMed/Medline, Cochrane, and Embase databases from January 2000 to April 2016 were queried. Inclusion criteria were any study that reported the prevalence of urethral strictures following external beam radiation therapy (EBRT), brachytherapy (BT), or both as a primary treatment for PCa...
January 2, 2018: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29282360/serum-cholesterol-and-risk-of-high-grade-prostate-cancer-results-from-the-reduce-study
#20
Juzar Jamnagerwalla, Lauren E Howard, Emma H Allott, Adriana C Vidal, Daniel M Moreira, Ramiro Castro-Santamaria, Gerald L Andriole, Michael R Freeman, Stephen J Freedland
BACKGROUND: Epidemiologic evidence for a serum cholesterol-prostate cancer link is mixed. Prostate-specific antigen (PSA) is positively correlated with cholesterol, potentially increasing PSA-driven biopsy recommendations in men with high cholesterol, though biopsy compliance may be lower in men with comorbid conditions. These potential biases may affect PSA-driven biopsy rates and subsequent prostate cancer detection in men with high serum cholesterol. Our objective was to test the association between serum cholesterol and prostate cancer risk in men receiving PSA independent, study-mandated prostate biopsies...
December 27, 2017: Prostate Cancer and Prostatic Diseases
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