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Prostate Cancer and Prostatic Diseases

journal
https://www.readbyqxmd.com/read/29125150/contemporary-management-of-men-with-high-risk-localized-prostate-cancer-in-the-united-states
#1
A B Weiner, R S Matulewicz, E M Schaeffer, S L Liauw, J M Feinglass, S E Eggener
This corrects the article DOI: 10.1038/pcan.2017.5.
December 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28762374/molecular-alterations-in-prostate-cancer-and-association-with-mri-features
#2
D Lee, J Fontugne, N Gumpeni, K Park, T Y MacDonald, B D Robinson, A Sboner, M A Rubin, J M Mosquera, C E Barbieri
BACKGROUND: Multiparametric magnetic resonance imaging (mpMRI) has been increasingly used for prostate cancer (PCa). Recent studies identified distinct molecular subclasses of PCa with recurrent genomic alterations. However, the associations between molecular alterations in PCa and characteristics on mpMRI are unknown. Therefore, the objective of this study was to investigate recurrent molecular alterations in PCa and their associations with mpMRI features. METHODS: Sixty-two PCa nodules >0...
December 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28762373/changes-in-prostate-cancer-detection-rate-of-mri-trus-fusion-vs-systematic-biopsy-over-time-evidence-of-a-learning-curve
#3
B Calio, A Sidana, D Sugano, S Gaur, A Jain, M Maruf, S Xu, P Yan, J Kruecker, M Merino, P Choyke, B Turkbey, B Wood, P Pinto
BACKGROUND: To determine the effect of urologist and radiologist learning curves and changes in MRI-TRUS fusion platform during 9 years of NCI's experience with multiparametric magnetic resonance imaging (mpMRI)/TRUS fusion biopsy. METHODS: A prospectively maintained database of patients undergoing mpMRI followed by fusion biopsy (Fbx) and systematic biopsy (Sbx) from 2007 to 2016 was reviewed. The patients were stratified based on the timing of first biopsy. Cohort 1 (7/2007-12/2010) accounted for learning curve...
December 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28695916/the-impact-of-sociodemographic-factors-and-psa-screening-among-low-income-black-and-white-men-data-from-the-southern-community-cohort-study
#4
K A Moses, Z Zhao, Y Bi, J Acquaye, A Holmes, W J Blot, J H Fowke
BACKGROUND: Variation in PSA screening is a potential source of disparity in prostate cancer survival, particularly among underserved populations. We sought to examine the impact of race and socioeconomic status (SES) on receipt of PSA testing among low-income men. METHODS: Black (n=22 167) and White (n=9588) men aged ⩾40 years completed a baseline questionnaire from 2002 to 2009 as part of the Southern Community Cohort Study. Men reported whether they had ever received PSA testing and had testing within the prior 12 months...
December 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28653675/periprostatic-adipose-inflammation-is-associated-with-high-grade-prostate-cancer
#5
A Gucalp, N M Iyengar, X K Zhou, D D Giri, D J Falcone, H Wang, S Williams, M D Krasne, I Yaghnam, B Kunzel, P G Morris, L W Jones, M Pollak, V P Laudone, C A Hudis, H I Scher, P T Scardino, J A Eastham, A J Dannenberg
BACKGROUND: Obesity, a cause of subclinical inflammation, is associated with increased risk of high-grade prostate cancer (PC) and poor outcomes. Whether inflammation occurs in periprostatic white adipose tissue (WAT), and contributes to the negative impact of obesity on PC aggressiveness, is unknown. METHODS: In a single-center, cross-sectional design, men with newly diagnosed PC undergoing radical prostatectomy were eligible for study participation. The primary objective was to examine the prevalence of periprostatic WAT inflammation defined by the presence of crown-like structures (CLS-P) as detected by CD68 immunohistochemistry...
December 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28585573/tools-for-predicting-patient-reported-outcomes-in-prostate-cancer-patients-undergoing-radical-prostatectomy-a-systematic-review-of-prognostic-accuracy-and-validity
#6
REVIEW
M E O'Callaghan, E Raymond, J Campbell, A D Vincent, K Beckmann, D Roder, S Evans, J McNeil, J Millar, J Zalcberg, M Borg, K Moretti
BACKGROUND: Radical prostatectomy is a common surgical procedure performed to treat prostate cancer. Patient-reported outcomes after surgery include urinary incontinence, erectile dysfunction, decreased quality of life and psychological effects. Predictive tools to assess the likelihood of an individual experiencing various patient-reported outcomes have been developed to aid decision-making when selecting treatment. METHODS: A systematic review was undertaken to identify all papers describing tools for the prediction of patient-reported outcome measures in men with prostate cancer treated with radical prostatectomy...
December 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28585572/the-combination-of-histological-prostate-atrophy-and-inflammation-is-associated-with-lower-risk-of-prostate-cancer-in-biopsy-specimens
#7
D M Moreira, D M de O Freitas, J C Nickel, G L Andriole, R Castro-Santamaria, S J Freedland
BACKGROUND: To evaluate whether the presence of both prostate atrophy (PA) and chronic prostate inflammation (CPI) in the same biopsy and in the same biopsy core are associated with prostate cancer (PCa) risk and grade in repeat biopsies. METHODS: Retrospective analyses of 6132 men who were 50-75 years old undergoing 2-year repeat prostate biopsy after a negative baseline biopsy for PCa in the REduction by DUtasteride of prostate Cancer Events (REDUCE) study. PA, CPI and PCa were determined by central pathology...
December 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28485390/the-survival-impact-of-neoadjuvant-hormonal-therapy-before-radical-prostatectomy-for-treatment-of-high-risk-prostate-cancer
#8
L Tosco, A Laenen, A Briganti, P Gontero, R J Karnes, M Albersen, P J Bastian, P Chlosta, F Claessens, F K Chun, W Everaerts, C Gratzke, M Graefen, B Kneitz, G Marchioro, R S Salas, B Tombal, T Van den Broeck, L Moris, A Battaglia, H van der Poel, J Walz, A Bossi, G De Meerleer, K Haustermans, H Van Poppel, M Spahn, S Joniau
BACKGROUND: Several randomized controlled trials assessed the outcomes of patients treated with neoadjuvant hormonal therapy (NHT) before radical prostatectomy (RP). The majority of them included mainly low and intermediate risk prostate cancer (PCa) without specifically assessing PCa-related death (PCRD). Thus, there is a lack of knowledge regarding a possible effect of NHT on PCRD in the high-risk PCa population. We aimed to analyze the effect of NHT on PCRD in a multicenter high-risk PCa population treated with RP, using a propensity-score adjustment...
December 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28462945/select-men-benefit-from-androgen-deprivation-therapy-delivered-with-salvage-radiation-therapy-after-prostatectomy
#9
E B Holliday, D A Kuban, L B Levy, Y Bolukbasi, P Master, S Choi, Q Nguyen, S E McGuire, U Mahmood, S J Frank, K E Hoffman
BACKGROUND: Which men benefit most from adding androgen deprivation therapy (ADT) to salvage radiation therapy (SRT) after prostatectomy has not clearly been defined; therefore, we evaluated the impact of ADT to SRT on failure-free survival (FFS) in men with a rising or persistent PSA after prostatectomy. METHODS: We identified 332 men who received SRT after prostatectomy from 1987 to 2010. Recursive partitioning analysis (RPA) identified favorable, intermediate and unfavorable groups based on the risk of failure after SRT alone...
December 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28462944/functional-outcomes-of-clinically-high-risk-prostate-cancer-patients-treated-with-robot-assisted-radical-prostatectomy-a-multi-institutional-analysis
#10
F Abdollah, D Dalela, A Sood, J Sammon, R Cho, L Nocera, M Diaz, W Jeong, J O Peabody, N Fossati, G Gandaglia, A Briganti, F Montorsi, M Menon
BACKGROUND: To ascertain 3-year urinary continence (UC) and sexual function (SF) recovery following robot-assisted radical prostatectomy (RARP) for clinically high-risk prostate cancer (PCa). METHODS: Retrospective analyses of a prospectively maintained database for 769 patients with D'Amico high-risk PCa undergoing RARP at two tertiary care centers in the United States and Europe between 2001 and 2014. The association between time since RARP and recovery of UC (defined as 0 pad/one safety liner per day) and SF (defined as sexual health inventory for men (SHIM) score ⩾17) was tested in separate preoperative and post-operative Cox-proportional hazards regression models...
December 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28462943/media-reporting-of-protect-a-disconnect-in-information-dissemination
#11
M E Westerman, B Bhindi, R Choo, M T Gettman, R J Karnes, L Klotz, S A Boorjian
BACKGROUND: Given the central role of the media in disseminating information to the public, we analyzed news coverage of the recent publication from ProtecT to assess views on treatment, the level of detail presented and degree of bias. METHODS: We applied a predefined search strategy to identify all news articles reporting on ProtecT within 30 days of its publication. Articles were independently assessed by two urologists and two lay persons using five-point Likert scales...
December 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28440323/increased-dietary-and-circulating-lycopene-are-associated-with-reduced-prostate-cancer-risk-a-systematic-review-and-meta-analysis
#12
REVIEW
J L Rowles, K M Ranard, J W Smith, R An, J W Erdman
BACKGROUND: Prostate cancer (PCa) is the fifth leading cause of cancer-related deaths worldwide. Many epidemiological studies have investigated the association between prostate cancer and lycopene, however, results have been inconsistent. This study aims to determine the impact of dietary and circulating concentrations of lycopene on PCa risk and to investigate potential dose-response associations. METHODS: We conducted a systematic review and dose-response meta-analysis for the for the association between dietary and circulating lycopene and PCa risk...
December 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28631720/contemporary-management-of-men-with-high-risk-localized-prostate-cancer-in-the-united-states
#13
A B Weiner, R S Matulewicz, E M Schaeffer, S L Liauw, J M Feinglass, S E Eggener
BACKGROUND: Surgery and radiation-based therapies are standard management options for men with clinically localized high-risk prostate cancer (PCa). Contemporary patterns of care are unknown. We hypothesize the use of surgery has steadily increased in more recent years. METHODS: Using the National Cancer Data Base for 2004-2013, all men diagnosed with high-risk localized PCa were identified using National Comprehensive Cancer Network criteria. Temporal trends in initial management were assessed...
September 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28485391/magnetic-resonance-imaging-targeted-transperineal-prostate-biopsy-a-local-anaesthetic-approach
#14
E J Bass, I A Donaldson, A Freeman, C Jameson, S Punwani, C Moore, M Arya, M Emberton, H U Ahmed
BACKGROUND: Despite high rates of disease misclassification and sepsis, the use of transrectal biopsy remains commonplace. Transperineal mapping biopsies mitigate these problems but carry increased cost and patient burden. Local anaesthetic, multiparametric magnetic resonance imaging (MRI)-targeted transperineal biopsy may offer an alternative. Here, we aim to determine the feasibility, tolerability and detection rates of clinically significant prostate cancer using a local anaesthetic, transperineal, MRI-targeted biopsy technique...
September 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28440321/association-of-comorbid-disease-burden-at-diagnosis-with-higher-tumor-grade-in-men-with-non-metastatic-prostate-cancer
#15
T J Daskivich, C J Dru, D Skarecky, T Ahlering, S J Freedland
BACKGROUND: While older age is associated with higher tumor grade, it is unknown whether comorbid disease burden has a similar, independent association. We sought to evaluate the impact of comorbid disease burden on tumor grade at diagnosis as indicated by biopsy Gleason score. METHODS: We conducted an observational cohort study of 1260 men newly diagnosed with non-metastatic prostate cancer from 1998 to 2004 at two Veterans Affairs Medical Centers. Multivariable ordinal and multinomial logistic regression were used to evaluate the association between Charlson Comorbidity Index score and biopsy Gleason score...
September 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28440320/a-review-of-pomegranate-in-prostate-cancer
#16
REVIEW
C J Paller, A Pantuck, M A Carducci
BACKGROUND: Preclinical studies showing that pomegranate juice and its components inhibit prostate cancer led to multiple clinical trials to determine whether pomegranate products could slow the growth of prostate cancer. This review summarizes the preclinical data and discusses the results of the clinical trials. METHODS: Trials targeted patients on active surveillance, neoadjuvant patients, patients with biochemical recurrence (BCR) following local therapy for prostate cancer, and patients with metastatic castration-resistant prostate cancer (mCRPC)...
September 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28417979/longitudinal-assessment-of-urinary-pca3-for-predicting-prostate-cancer-grade-reclassification-in-favorable-risk-men-during-active-surveillance
#17
J J Tosoian, H D Patel, M Mamawala, P Landis, S Wolf, D J Elliott, J I Epstein, H B Carter, A E Ross, L J Sokoll, C P Pavlovich
BACKGROUND: To assess the utility of urinary prostate cancer antigen 3 (PCA3) as both a one-time and longitudinal measure in men on active surveillance (AS). METHODS: The Johns Hopkins AS program monitors men with favorable-risk prostate cancer with serial PSA, digital rectal examination (DRE), prostate magnetic resonance imaging and prostate biopsy. Since 2007, post-DRE urinary specimens have also been routinely obtained. Men with multiple PCA3 measures obtained over ⩾3 years of monitoring were included...
September 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28398294/long-term-allopurinol-use-decreases-the-risk-of-prostate-cancer-in-patients-with-gout-a-population-based-study
#18
H-J Shih, M-C Kao, P-S Tsai, Y-C Fan, C-J Huang
BACKGROUND: Clinical observations indicated an increased risk of developing prostate cancer in gout patients. Chronic inflammation is postulated to be one crucial mechanism for prostate carcinogenesis. Allopurinol, a widely used antigout agent, possesses potent anti-inflammation capacity. We elucidated whether allopurinol decreases the risk of prostate cancer in gout patients. METHODS: We analyzed data retrieved from Taiwan National Health Insurance Database between January 2000 and December 2012...
September 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28374743/extracellular-vesicles-for-liquid-biopsy-in-prostate-cancer-where-are-we-and-where-are-we-headed
#19
REVIEW
V R Minciacchi, A Zijlstra, M A Rubin, D Di Vizio
BACKGROUND: Extracellular vesicles (EVs) are a heterogeneous class of lipid bound particles shed by any cell in the body in physiological and pathological conditions. EVs play critical functions in intercellular communication. EVs can actively travel in intercellular matrices and eventually reach the circulation. They can also be released directly in biological fluids where they appear to be stable. Because the molecular content of EVs reflects the composition of the cell of origin, they have recently emerged as a promising source of biomarkers in a number of diseases...
September 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28349978/patient-selection-for-prostate-focal-therapy-in-the-era-of-active-surveillance-an-international-delphi-consensus-project
#20
K J Tay, M J Scheltema, H U Ahmed, E Barret, J A Coleman, J Dominguez-Escrig, S Ghai, J Huang, J S Jones, L H Klotz, C N Robertson, R Sanchez-Salas, S Scionti, A Sivaraman, J de la Rosette, T J Polascik
BACKGROUND: Whole-gland extirpation or irradiation is considered the gold standard for curative oncological treatment for localized prostate cancer, but is often associated with sexual and urinary impairment that adversely affects quality of life. This has led to increased interest in developing therapies with effective cancer control but less morbidity. We aimed to provide details of physician consensus on patient selection for prostate focal therapy (FT) in the era of contemporary prostate cancer management...
September 2017: Prostate Cancer and Prostatic Diseases
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