Martina Prelog, Samuel D Jeske, Claudia Asam, Andre Fuchs, Andreas Wieser, Christine Gall, Monika Wytopil, Sandra M Mueller-Schmucker, Stephanie Beileke, Mehmet Goekkaya, Elisabeth Kling, Christof Geldmacher, Raquel Rubio-Acero, Michael Plank, Catharina Christa, Annika Willmann, Martin Vu, Sebastian Einhauser, Manuela Weps, Benedikt M J Lampl, Giovanni Almanzar, Kimia Kousha, Valeria Schwägerl, Bernhard Liebl, Beatrix Weber, Johannes Drescher, Jörg Scheidt, Olaf Gefeller, Helmut Messmann, Ulrike Protzer, Johannes Liese, Michael Hoelscher, Ralf Wagner, Klaus Überla, Philipp Steininger
BACKGROUND: SARS-CoV-2 variants of concern (VOC) may result in breakthrough infections (BTIs) in vaccinated individuals. The aim of this study was to investigate the effects of full primary (two-dose) COVID-19 vaccination with wild-type-based SARS-CoV-2 vaccines on symptoms and immunogenicity of SARS-CoV-2 VOC BTIs. METHODS: In a longitudinal multicenter controlled cohort study in Bavaria, Germany, COVID-19 vaccinated and unvaccinated non-hospitalized individuals were prospectively enrolled within 14 days of a PCR-confirmed SARS-CoV-2 infection...
November 28, 2023: Journal of Clinical Virology