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Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology

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https://www.readbyqxmd.com/read/30399502/surveillance-and-molecular-characterization-of-human-adenovirus-in-patients-with-acute-gastroenteritis-in-the-era-of-rotavirus-vaccine-brazil-2012-2017
#1
Dieli Primo, Gabriela Tayna Pacheco, Maria do Carmo Sampaio Tavares Timenetsky, Adriana Luchs
BACKGROUND: In Brazil, limited data are available regarding the incidence and molecular epidemiology of Human Adenovirus (HAdV) in diarrheic disease, especially in the post rotavirus (RVA) vaccine era. OBJECTIVE: The aims of the study were to investigate the frequency of HAdV infections in patients with gastroenteritis during a 6-year period (2012-2017); conduct molecular typing of positive strains, and obtain further information on the HAdV seasonality. STUDY DESIGN: A total of 3003 fecal samples negative for both, RVA and Norovirus, were selected and tested for HAdV by PCR...
November 1, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/30419551/a-single-center-single-blind-study-to-evaluate-the-clinical-sensitivity-specificity-and-agreement-between-elecsys-anti-hbc-ii-and-elecsys-anti-hbc-in-a-korean-population
#2
Taegeun Lee, John Jeongseok Yang, Jinseok Eom, Sohee Kwon, Borae G Park, Sang-Hyun Hwang, Heung-Bum Oh
BACKGROUND: Anti-HBc IgG is almost always detected in hepatitis B virus (HBV)-infected individuals and persists in resolved infections. In certain cases, anti-HBc IgG is the only serological marker and anti-HBc-positive result generally means anti-HBc total positivity. OBJECTIVES: To evaluate the clinical sensitivity and specificity of an investigational medical device, Elecsys Anti-HBc II, using samples from the Korean population. Agreement between Elecsys Anti-HBc II and its widely utilized predecessor Elecsys Anti-HBc was also evaluated...
October 28, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/30388664/usefulness-of-a-serial-algorithm-of-hbsag-and-hbeag-rapid-diagnosis-tests-to-detect-pregnant-women-at-risk-of-hbv-mother-to-child-transmission-in-cambodia-the-anrs-12328-pilot-study
#3
Olivier Ségéral, Dieynaba S N'Diaye, Sophearot Prak, Janin Nouhin, Samsorphea Chhun, Wootichai Khamduang, Kenrena Chim, Anne-Marie Roque-Afonso, Patrice Piola, Laurence Borand, Nicole Ngo-Giang-Huong, François Rouet
BACKGROUND: In Cambodia, access to hepatitis B surface antigen (HBsAg) screening is low for pregnant women and Hepatitis B Virus (HBV) DNA quantification is poorly accessible. OBJECTIVES: To evaluate the performance of a serial algorithm using two HBV rapid diagnostic tests (RDTs), in which samples positive for HBsAg were further tested for HBeAg as a surrogate marker for HBV DNA quantification. STUDY DESIGN: In 2015, we prospectively collected plasma samples from 250 pregnant women consulting for antenatal care in one hospital in Phnom Penh including 128 with a known positive HBsAg status...
October 22, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/30388662/diagnosis-of-rotavirus-infection-in-a-vaccinated-population-is-a-less-sensitive-immunochromatographic-method-more-suitable-for-detecting-wild-type-rotavirus-than-real-time-rt-pcr
#4
Z Yandle, S Coughlan, R J Drew, J Cleary, C De Gascun
BACKGROUND: Diagnosis of wild-type rotavirus disease may be complicated by the detection of vaccine-derived virus which can be detected in stool samples following immunisation. We evaluate an immunochromatographic assay and real-time RT-PCR to determine which is more suitable for the detection of wild-type rotavirus. OBJECTIVES: To compare the Ct values of wild-type rotavirus and Rotarix determined by real-time RT-PCR. To establish the Ct value corresponding to the limit of detection of the immunochromatographic Combi-Strip method (Coris, BioConcept)...
October 18, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/30388663/evaluation-of-performance-characteristics-of-hepatitis-b-e-antigen-serologic-assays
#5
Tonya Mixson-Hayden, Michael A Purdy, Lilia Ganova-Raeva, Daniel McGovern, Joseph C Forbi, Saleem Kamili
BACKGROUND: Hepatitis B e antigen (HBeAg) is considered an indicator of high hepatitis B virus (HBV) replication. Performance characteristics of commercially available HBeAg assays have not been determined, thus it is unknown whether lack of HBeAg detection is because of test sensitivity or HBV basal core promoter and precore mutations. OBJECTIVES: We studied the correlation between HBeAg reactivity with HBV DNA levels in three commercially available HBeAg assays using 335 HBsAg and HBV DNA positive serum/plasma samples...
October 13, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/30368218/hpv-genotyping-and-e6-e7-transcript-assays-for-cervical-lesion-detection-in-an-asian-screening-population-cobas-and-aptima-hpv-tests
#6
Oscar G W Wong, Obe K L Tsun, Eva Y Tsui, Joanne N K Chow, Philip P C Ip, Annie N Y Cheung
BACKGROUND: High-risk human papillomavirus (hrHPV) detection and genotyping by Cobas HPV test has become an important technical platform in cervical cancer screening. It may be used as a co-test with cervical cytology or as a standalone test. Aptima HPV assay (AHPV) is another hrHPV test detecting 13 genotypes through qPCR based amplification of viral E6/E7 transcripts. Partial genotyping with Aptima HPV 16 18/45 genotype assay (AHPV GT) on positive samples is possible. Evidence supporting the performance of AHPV in Asian populations is scarce...
October 13, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/30343190/risk-factors-for-bk-virus-viremia-and-nephropathy-after-kidney-transplantation-a-systematic-review
#7
REVIEW
Baptiste Demey, Claire Tinez, Catherine François, François Helle, Gabriel Choukroun, Gilles Duverlie, Sandrine Castelain, Etienne Brochot
In the last 20 years, the management of BK polyomavirus (BKPyV) reactivation in kidney transplant patients has become a true challenge for the transplant community. The only treatment option is based on the early identification of at-risk patients. The number of reported risk factors for BKPyV reactivation has increased markedly in the literature last years, although they are sometimes in an unclear or contradictory manner. Our purpose is to provide a systematic review and meta-analysis of risk factors for BKPyV viremia and nephropathy described in multivariate analyses...
October 12, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/30336371/performance-of-a-commercial-assay-for-detecting-and-quantifying-hev-rna-in-faeces
#8
Florence Abravanel, Audrey Lacipière, Sébastien Lhomme, Martine Dubois, Luce Minier, Jean-Marie Peron, Laurent Alric, Nassim Kamar, Jacques Izopet
BACKGROUND: Detecting hepatitis E virus (HEV) RNA in faeces is useful for diagnosing and monitoring HEV infections, particularly in immunocompromised patients requiring ribavirin therapy. OBJECTIVES: This study evaluated the performance of the Altona RealStar HEV RNA kit for detecting and quantifying HEV in faeces. STUDY DESIGN: RNA was extracted from 94 stool samples by two methods: QIAamp Viral RNA Mini kit and MagNA Pure 96 automate. The Altona results were compared to a reference laboratory-developed accredited ISO15189 RT-PCR assay...
October 10, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/30312909/cd4-t-cell-responses-to-flaviviruses
#9
REVIEW
Judith H Aberle, Maximilian Koblischke, Karin Stiasny
Flaviviruses pose an increasing threat to global health with their potential to cause severe disease in millions of people. Protective and long-lived immunity is closely linked to the generation of CD4 T cells, which provide B cell help and support high affinity neutralizing antibody responses. Research performed during the last years revealed important new insights into the antigen specificities and diverse effector functions of CD4 T cell responses to flaviviruses. Moreover, the identification of mechanisms involved in the regulation of T cell specificity and function provides significant advances in our understanding of how durable protective immunity is established...
October 3, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/30316173/neonatal-hcmv-related-polymicrogyria-in-seroimmune-women-what-is-the-optimal-pregnancy-management
#10
Maurizio Zavattoni, Giuseppina Lombardi, Francesca Garofoli, Guido Scalia, Annalisa Rizzo, Micol Angelini, Antonella Sarasini, Milena Furione, Fausto Baldanti
BACKGROUND: Human cytomegalovirus (HCMV) infection is the most common congenital infection in developed countries. Recent studies highlighted similar percentages of symptoms in HCMV congenitally-infected infants following either primary or non-primary maternal infections. OBJECTIVES: To highlight correlation between neonatal brain abnormalities, detected by ultrasounds and magnetic resonance image in HCMV congenitally-infected infants, and maternal virological parameters during pregnancy, especially in seroimmune mothers...
October 2, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/30312910/biological-relevance-of-cytomegalovirus-genetic-variability-in-congenitally-and-postnatally-infected-children
#11
Ganna Galitska, Matteo Biolatti, Marco De Andrea, Agata Leone, Alessandra Coscia, Luigi Bertolotti, Ugo Ala, Enrico Bertino, Valentina Dell'Oste, Santo Landolfo
BACKGROUND: Human cytomegalovirus (HCMV) is the leading cause of congenital infections resulting in severe morbidity and mortality among infected children. Although the virus is highly polymorphic, particularly in genes contributing to immune evasion, the mechanisms underlying its genetic variability and pathogenicity are only partially understood. OBJECTIVES: We aimed to characterize different HCMV clinical strains isolated from 21 congenitally- or postnatally-infected children for in vitro growth properties and genetic polymorphisms...
October 2, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/30296744/virome-definition-in-cerebrospinal-fluid-of-patients-with-neurological-complications-after-hematopoietic-stem-cell-transplantation
#12
C Pou, M Barrientos-Somarribas, S Marin-Juan, G Bogdanovic, A Bjerkner, T Allander, B Gustafsson, B Andersson
BACKGROUND: Neurological complications (NC) in allogeneic hematopoietic stem cell transplant (HSCT) recipients lead to long-term sequelae and result in significant morbidity and mortality. Since risk factors for NC include viral infection or reactivation, virome inspection after HSCT might be helpful to the clinical management of patients after HSCT. OBJECTIVES AND STUDY DESIGN: In this study we investigated whether any viruses are found in association with NC after HSCT...
September 30, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/30300787/recognition-treatment-and-sequelae-of-congenital-cytomegalovirus-in-australia-an-observational-study
#13
Adam W Bartlett, Beverley M Hall, Pamela Palasanthiran, Brendan McMullan, Antonia W Shand, William D Rawlinson
BACKGROUND AND OBJECTIVES: Australian national surveillance data was used to assess recognition, sequelae, and antiviral therapy for congenital cytomegalovirus (CMV) cases. STUDY DESIGN: Data from congenital CMV cases reported through the Australian Paediatric Surveillance Unit born January 1999 to December 2016 were described and Chi-square tests used to characterise trends and associations in case reporting, maternal CMV serology testing, and antiviral therapy...
September 27, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/30290324/is-active-hepatitis-c-associated-with-the-size-of-hiv-reservoir-in-successfully-treated-patients
#14
LETTER
M Vassallo, J Durant, M Ticchioni, A Demonte, R Fabre, C Pradier, J Cottalorda
No abstract text is available yet for this article.
September 27, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/30292135/differences-in-the-ease-with-which-mutant-viruses-escape-from-human-monoclonal-antibodies-against-the-ha-stem-of-influenza-a-virus
#15
Seiya Yamayoshi, Atsuhiro Yasuhara, Mutsumi Ito, Ryuta Uraki, Yoshihiro Kawaoka
BACKGROUND: Broadly protective human monoclonal antibodies that recognize the conserved epitopes in the HA of influenza A virus are being developed as therapeutic agents. Emergence of resistant viruses must always be considered when developing therapeutic agents against influenza. OBJECTIVES: We examined human hetero-reactive mAbs against the HA stem of influenza A virus for the ease with which escape mutant viruses emerged. STUDY DESIGN: We attempted to generate the mutant viruses escaped from the hetero-reactive anti-HA stem antibodies...
September 26, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/30268000/within-host-evolution-of-virus-variants-during-chronic-infection-with-novel-gii-p26-gii-26-norovirus
#16
Corinna Pietsch, Nora Ennuschat, Sabine Härtel, Uwe G Liebert
BACKGROUND: Noroviruses are a leading cause of acute gastroenteritis in all age groups. They generally cause a rapidly self-limiting illness. However, chronic norovirus diarrheal disease occurs in immunocompromised individuals, and is accompanied by persistent shedding of infectious norovirus in stool. OBJECTIVES: The study aims to characterize a novel GII.P26-GII.26 norovirus strain. Furthermore, it analyses viral mutations arising during chronic infection of an immunocompromised host...
September 19, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/30266004/evaluation-of-the-vitros-hiv-combo-4th-generation-test-for-the-identification-of-hiv-infections
#17
Massimo De Paschale, Maria Teresa Manco, Annalisa Cianflone, Luisa Belvisi, Debora Cagnin, Teresa Cerulli, Alessia Paganini, Carlo Agrappi, Paola Mirri, Pierangelo Clerici
BACKGROUND: Simultaneous detection of HIV 1 and 2 antibodies and HIV-1 p-24 antigen in the 4th generation tests is particularly effective for the identification of early acute HIV infections while maintaining accurate detection of long-established infections. OBJECTIVES: The aim of this study was to evaluate the new 4th generation VITROS HIV Combo test from Ortho-Clinical Diagnostics by comparing its results with those obtained using a 3rd generation HIV 1/2 antibody test (VITROS Anti HIV 1 + 2 from Ortho-Clinical Diagnostics) and a 4th generation test (LIAISON XL HIV Ab/Ag, DiaSorin) currently used in the Microbiology Unit of Legnano Hospital...
September 17, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/30253376/the-valgent4-protocol-robust-analytical-and-clinical-validation-of-11-hpv-assays-with-genotyping-on-cervical-samples-collected-in-surepath-medium
#18
Jesper Bonde, Ditte Møller Ejegod, Kate Cuschieri, Joakim Dillner, Daniëlle A M Heideman, Wim Quint, Miguel Angel Pavon Ribas, Elizaveta Padalko, Irene Kraus Christiansen, Lan Xu, Marc Arbyn
BACKGROUND: The VALidation of HPV GENoyping Tests (VALGENT) is an international initiative designed to validate HPV assays with genotyping capability. The VALGENT4 protocol differs from previous VALGENT installments as the sample collection medium is SurePath, and exclusively includes samples from women ≥30 years of age which is concordant with the majority of HPV primary screening guidelines. Here we present the protocol for the fourth installment of the VALGENT framework. OBJECTIVES: In VALGENT4 11 HPV assays will be evaluated using two comparator assays based on PCR with the GP5+/6+ primers...
September 17, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/30245364/analytical-and-field-evaluation-of-the-biocentric-generic-hcv-assay-on-open-polyvalent-pcr-platforms-in-france-and-cambodia
#19
J Nouhin, K Bollore, J Castera-Guy, S Prak, S Heng, A Kerleguer, P A Rubbo, F Rouet, E Tuaillon
BACKGROUND: Implementation of affordable methods for HCV viremia is a key priority for identifying individuals who need treatment among persons screened positive for HCV antibodies. Different HCV PCR assays for use on open polyvalent PCR platforms are currently commercially available but studies evaluating the performances of these nucleic acid tests are needed. OBJECTIVES: In the present study, we evaluated the analytical and clinical performances of a recently developed HCV RNA PCR assay for detection and quantification of HCV viremia...
September 17, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/30261422/using-a-novel-rapid-viral-test-to-improve-triage-of-emergency-department-patients-with-acute-respiratory-illness-during-flu-season
#20
Courtney J Pedersen, Daniel T Rogan, Samuel Yang, James V Quinn
BACKGROUND: Acute respiratory illnesses (ARI) are mostly viral in etiology and cause significant morbidity and mortality. Point of care PCR (POC-PCR) is a promising new technology for rapid virus identification but utility in the Emergency Department (ED) is not yet defined. OBJECTIVES: Primarily, to investigate the value of POC-PCR in rapidly identifying RSV and influenza in the setting of ED triage. Additionally, to assess whether rapid knowledge of accurate test results would improve patient management by preventing nosocomial transmission and optimizing the prescription of antimicrobials for ARIs...
September 15, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
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