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Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology

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https://www.readbyqxmd.com/read/28734139/%C3%AE-nfluenza-a-h3n2-genetic-variants-in-vaccinated-patients-in-northern-greece
#1
A Melidou, G Gioula, M Exindari, E Ioannou, K Gkolfinopoulou, T Georgakopoulou, S Tsiodras, A Papa
BACKGROUND: Influenza A(H3N2) viruses predominated during the influenza 2016/2017 season and showed extensive genetic diversification. A high vaccination failure rate was noticed during the 2016/17 season in Greece, especially among the elderly. OBJECTIVES: The scope of the study was to investigate the genetic characteristics of A(H3N2) circulating viruses and viruses detected in vaccinated patients. STUDY DESIGN: Virus samples originated from vaccinated and unvaccinated patients, obtained at the National Influenza Centre for northern Greece...
July 14, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28734140/deregulation-of-levels-of-angiopoietin-1-and-angiopoietin-2-is-associated-with-severe-courses-of-hantavirus-infection
#2
Christian Nusshag, Anja Osberghaus, Alexandra Baumann, Paul Schnitzler, Martin Zeier, Ellen Krautkrämer
BACKGROUND: Hantavirus disease is characterized by endothelial dysfunction. Angiopoietin-1 (Ang-1) and its antagonist angiopoietin-2 (Ang-2) play a key role in the control of capillary permeability. Ang-1 is responsible for maintenance of cell-to-cell contacts whereas Ang-2 destabilizes monolayers. An imbalance of Ang-1 and Ang-2 levels results in enhanced permeability and capillary leakage. OBJECTIVES: To analyze the involvement of angiopoietins in hantavirus-induced disruption of endothelia, we measured the levels of Ang-1 and Ang-2 in hantavirus infection...
July 11, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28710997/dynamics-of-torque-teno-virus-plasma-dnaemia-in-allogeneic-stem-cell-transplant-recipients
#3
Eliseo Albert, Carlos Solano, Tania Pascual, Ignacio Torres, Lisa Macera, Daniele Focosi, Fabrizio Maggi, Estela Giménez, Paula Amat, David Navarro
BACKGROUND: Torque Teno virus (TTV) plasma DNA load directly correlate with the level of immunosuppresion in different clinical settings. It is uncertain whether this may be the case in allogeneic hematopoietic stem cell transplant recipients (allo-HSCT). OBJECTIVES: We characterized the dynamics of TTV DNAemia in patients undergoing T-cell replete allo-SCT. STUDY DESIGN: Retrospective single-center observational study including 72 allo-HSCT patients...
July 8, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28709006/compartmental-hbv-evolution-and-replication-in-liver-and-extrahepatic-sites-after-nucleos-tide-analogue-therapy-in-chronic-hepatitis-b-carriers
#4
Shan Gao, Zhong-Ping Duan, Yu Chen, Frank van der Meer, Samuel S Lee, Carla Osiowy, Guido van Marle, Carla S Coffin
BACKGROUND: Hepatitis B virus (HBV) variants are associated with nucleos/tide analogue (NA) response and liver disease but it is unknown whether NA influences extrahepatic HBV persistence. OBJECTIVES: To investigate HBV replication and genetic evolution in hepatic and extrahepatic sites of chronic hepatitis B (CHB) before and after NA therapy. STUDY DESIGN: A total of 13 paired plasma, peripheral blood mononuclear cells (PBMC), were collected from chronic HBV carriers at baseline and after a median 53 weeks NA therapy as well as liver biopsy (N=7 baseline, N=5 follow-up)...
July 5, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28710996/the-fourth-generation-alere-tm-hiv-combo-rapid-test-improves-detection-of-acute-infection-in-mtn-003-voice-samples
#5
Edward Livant, Amy Heaps, Cliff Kelly, Rashika Maharaj, Natasha Samsunder, Lindiwe Nhlangulela, Patrick Karugaba, Ravindre Panchia, Jeanne Marrazzo, Zvavahera Mike Chirenje, Urvi M Parikh
BACKGROUND: Early and accurate detection of HIV is crucial when using pre-exposure prophylaxis (PrEP) for HIV prevention to avoid PrEP initiation in acutely infected individuals and to minimize the risk of drug resistance in individuals with breakthrough infection. OBJECTIVE: To determine if fourth-generation antigen/antibody (Ag/Ab) rapid diagnostic tests (RDT) would have detected HIV infection earlier than the third-generation RDT used in MTN-003 (VOICE). STUDY DESIGN: 5029 VOICE participants were evaluated with third-generation Alere Determine™ HIV-1/2, OraQuick ADVANCE(®) Rapid HIV-1/2, Uni-Gold™ Recombigen(®) HIV-1/2 and Bio-Rad GS HIV-1/2+O EIA; and fourth-generation Alere Determine™ HIV-1/2 Ag/Ab Combo, Conformité Européene (CE)-Marked Alere™ HIV Combo and Bio-Rad HIV Combo Ag/Ab EIA...
June 29, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28697450/changes-in-genetically-drifted-h3n2-influenza-a-viruses-and-vaccine-effectiveness-in-adults-65-years-and-older-during-the-2016-17-season-in-denmark
#6
Ramona Trebbien, Thea K Fischer, Tyra G Krause, Lene Nielsen, Xiaohui Chen Nielsen, Lenette Sandborg Weinreich, Joanna Lis-Tønder, Marianne Nielsine Skov, Claus Bohn Christiansen, Hanne-Dorthe Emborg
BACKGROUND: In Denmark, influenza A virus of the subtype H3N2 has been dominating the 2016/17 season, as in most countries of the Northern Hemisphere. OBJECTIVES: This study was conducted as part of the Danish seasonal influenza surveillance programme to genetically characterize circulating H3N2 viruses and determine the seasonal vaccine effectiveness (VE) overall in the Danish population and further on the virus cluster level. STUDY DESIGN: Influenza virus positive samples submitted for the national surveillance programme were genetically characterized by sequencing...
June 29, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28649030/corrigendum-to-next-generation-sequencing-for-whole-genome-analysis-and-surveillance-of-influenza-a-viruses-j-clin-virol-79-2016-44-50
#7
Jana McGinnis, Jennifer Laplante, Matthew Shudt, Kirsten St George
No abstract text is available yet for this article.
June 22, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28618289/erratum-to-comparison-of-turnaround-time-and-total-cost-of-hiv-testing-before-and-after-implementation-of-the-2014-cdc-aphl-laboratory-testing-algorithm-for-diagnosis-of-hiv-infection-j-clin-virol-91-2017-69-72
#8
Derrick J Chen, Joseph D Yao
No abstract text is available yet for this article.
June 12, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28633097/results-of-the-first-international-hiv-1-coreceptor-proficiency-panel-test
#9
Eva Heger, Rolf Kaiser, Elena Knops, Maria Neumann-Fraune, Eugen Schuelter, Alejandro Pironti, Thomas Lengauer, Hauke Walter, Saleta Sierra
BACKGROUND: Quality Assurance (QA) programs are essential to evaluate performance in diagnostics laboratories. OBJECTIVES: We present the results from the first QA for HIV-1 genotypic tropism testing, organized and coordinated by the Institute of Virology at the University of Cologne. STUDY DESIGN: 12 cell culture-derived viral strains of different HIV-1 clades from the NIH AIDS Reagent Program were sent to the participants to be processed with their standard diagnostic methods Fasta files containing the V3 region sequence were centrally analyzed at the Institute of Virology, Cologne...
June 10, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28622640/clinical-course-and-core-variability-in-hbv-infected-patients-without-detectable-anti-hbc-antibodies
#10
Olympia E Anastasiou, Marek Widera, Jens Verheyen, Johannes Korth, Guido Gerken, Fabian A Helfritz, Ali Canbay, Heiner Wedemeyer, Sandra Ciesek
BACKGROUND: The presence of anti-HBc antibodies indicates direct encounter of the immune system with hepatitis B virus (HBV). OBJECTIVES: Aim of our study was to seek for anti-HBc negative but HBV replicating patients and analyze their clinical course and preconditions. STUDY DESIGN: From 1568 HBV-DNA positive patients, 29 patients (1.85%) tested negative for anti-HBc. The absence of anti-HBc could be confirmed in 19 patients using an alternative assay...
June 8, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28672275/genetic-divergence-of-influenza-a-h3n2-amino-acid-substitutions-mark-the-beginning-of-the-2016-2017-winter-season-in-israel
#11
Aharona Glatman-Freedman, Yaron Drori, Sharon Alexandra Beni, Nehemya Friedman, Rakefet Pando, Hanna Sefty, Ilana Tal, John McCauley, Galia Rahav, Nathan Keller, Tamy Shohat, Ella Mendelson, Musa Hindiyeh, Michal Mandelboim
BACKGROUND: Influenza vaccine composition is reevaluated each year due to the frequency and accumulation of genetic changes that influenza viruses undergo. The beginning of the 2016-2017 influenza surveillance period in Israel has been marked by the dominance of influenza A(H3N2). OBJECTIVES: To evaluate the type, subtype, genetic evolution and amino acid substitutions of influenza A(H3N2) viruses detected among community patients with influenza-like illness (ILI) and hospitalized patients with respiratory illness in the first weeks of the 2016-2017 influenza season...
June 4, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28633098/high-prevalence-of-cytomegalovirus-infection-in-surgical-intestinal-specimens-from-infants-with-necrotizing-enterocolitis-and-spontaneous-intestinal-perforation-a-retrospective-observational-study
#12
Soley Omarsdottir, Margret Agnarsdottir, Charlotte Casper, Abiel Orrego, Mireille Vanpée, Afsar Rahbar, Cecilia Söderberg-Nauclér
BACKGROUND: Necrotizing enterocolitis (NEC) is a severe, often fatal gastrointestinal emergency that predominantly affects preterm infants, and there is evidence that neonatal cytomegalovirus (CMV) infection may in some cases contribute to its pathogenesis. OBJECTIVES: This study aimed to evaluate the prevalence of CMV in infants with NEC. STUDY DESIGN: Seventy intestinal specimens from 61 infants with NEC, spontaneous intestinal perforation (SIP), or related surgical complications were collected at Karolinska University Hospital and Uppsala University Hospital, Sweden...
June 3, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28605724/human-parechovirus-cluster-in-the-uk-8-may-2-august-2016-sequence-analysis
#13
LETTER
C W Holmes, S Rahman, D J Allen, S Bandi, J W Tang
No abstract text is available yet for this article.
June 3, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28601677/impact-of-stem-cell-graft-on-early-viral-infections-and-immune-reconstitution-after-allogeneic-transplantation-in-adults
#14
Marina Illiaquer, Berthe-Marie Imbert-Marcille, Thierry Guillaume, Lucie Planche, Marie Rimbert, Céline Bressollette-Bodin, Amandine Le Bourgeois, Pierre Peterlin, Alice Garnier, Claire Le Houerou, Philippe Moreau, Mohamad Mohty, Patrice Chevallier
BACKGROUND: Viral infections are well-known complications after allogeneic stem cell transplant (allo-SCT). OBJECTIVES: We compared prospectively incidences of DNAemia and active infections (AI) for five opportunistic viruses (Human Herpesvirus 6 (HHV-6), Epstein-Barr virus (EBV), BK polyomavirus (BKPyV), Cytomegalovirus (CMV) and Adenovirus (ADV)) and kinetics of immune reconstitution (IR) in adults receiving either double umbilical cord blood (dUCB group) or unrelated peripheral blood stem cell (uPBSC group) allo-SCT after a reduced-intensity conditioning (RIC) regimen...
May 31, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28618288/an-enhanced-enterovirus-surveillance-system-allows-identification-and-characterization-of-rare-and-emerging-respiratory-enteroviruses-in-denmark-2015-16
#15
Céline Barnadas, Sofie E Midgley, Marianne N Skov, Lotte Jensen, Mille W Poulsen, Thea Kølsen Fischer
BACKGROUND: The potential for outbreaks due to Enteroviruses (EV) with respiratory tropism, such as EV-D68, and the detection of new and rare EV species C is a concern. These EVs are typically not detected in stool specimens and may therefore be missed by standard EV surveillance systems. Following the North American outbreak of EV-D68 in 2014, Denmark piloted an enhanced EV surveillance system that included the screening of respiratory samples. OBJECTIVES: We aim to report clinical manifestations and phylogenetic descriptions from the rare and emerging EVs identified thereby demonstrating the usefulness of this system...
May 29, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28564629/comparison-between-roche-and-xpert-in-hiv-1-rna-quantitation-a-high-concordance-between-the-two-techniques-except-for-a-crf02_ag-subtype-variant-with-high-viral-load-titters-detected-by-roche-but-undetected-by-xpert
#16
Boaz Avidor, Natalia Matus, Shirley Girshengorn, Svetlana Achsanov, Simona Gielman, Irene Zeldis, Inbal Schweitzer, Amos Adler, Dan Turner
BACKGROUND: HIV-1 viral load (VL) testing is important to predict viral progression and to monitor the response to antiretroviral therapy. New HIV-1 VL tests are continuously introduced to the market. Their performance is usually compared to Abbott and/or Roche HIV-1 VL assays, as reference. The Xpert HIV-1 VL test was recently introduced, but its performance compared to Roche has not been sufficiently studied. OBJECTIVES: To compare the Xpert assay with Roche and to assess its use in the HIV clinical laboratory...
May 19, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28531551/corrigendum-to-genedia-multi-influenza-ag-rapid-test-for-detection-and-h1-h3-and-h5-subtyping-of-influenza-viruses-j-clin-virol-73-2015-42-46
#17
Jin Woo Jang, Sun-Young Ko, Mun Sub Byoun, Haan Woo Sung, Chae Seung Lim
No abstract text is available yet for this article.
May 19, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28550722/inflammasome-expression-and-cytomegalovirus-viremia-in-critically-ill-patients-with-sepsis
#18
Nina Singh, Makoto Inoue, Ryosuke Osawa, Marilyn M Wagener, Mari L Shinohara
BACKGROUND: CMV viremia is a contributor to poor outcomes in critically ill patients with sepsis. OBJECTIVES: To assess the expression levels of genes encoding inflammasome-related proteins in the development of CMV viremia in critically ill patients with sepsis. STUDY DESIGN: A cohort of CMV-seropositive critically ill patients with sepsis due to bloodstream infection underwent weekly testing for CMV viremia. Blood samples to evaluate mRNA levels of genes encoding CASP1, ASC, NLRP1, NLRP3, and NLRP12 were collected at the time of enrollment...
May 18, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28550721/clinical-performance-of-the-veris-hcv-assay-for-hepatitis-c-virus-rna-quantification
#19
Laure Izquierdo, Corinne Prégermain, Corinne Hottelet, Gwenaëlle Decombe, Anne-Marie Roque-Afonso
BACKGROUND: Diagnosis of hepatitis C virus (HCV) infection and treatment monitoring rely on detection/quantification of HCV RNA and real-time polymerase chain reaction (PCR) techniques are expected to equivalently quantify the different HCV genotypes. OBJECTIVE: The clinical performance of the VERIS HCV assay for HCV RNA quantification was compared to that of the Abbott RealTime HCV assay. STUDY DESIGN: Qualitative concordance and quantitative comparison were evaluated on a first panel of 286 clinical samples containing HCV genotypes 1-6...
May 18, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28549336/evaluation-of-a-new-random-access-hbv-dna-molecular-assay-the-veris-hbv-assay
#20
Slim Fourati, Dominique Challine, Jean-Dominique Poveda, Syria Laperche, Sandrine Rallier, Jean-Michel Pawlotsky, Stéphane Chevaliez
BACKGROUND: Detection and quantification of HBV DNA are essential to diagnose chronic HBV infection, monitor the virological response to treatment and the possible selection of resistant viruses in order to tailor therapy. The VERIS/MDx System HBV Assay is a random-access system that quantifies HBV DNA in clinical samples using unique single sample and reagent access during the workflow process without the need to reload other tests and delivers results within 1.2h following sampling...
May 17, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
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