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Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs

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https://www.readbyqxmd.com/read/28932915/outcomes-in-patients-with-advanced-heart-failure-and-small-body-size-undergoing-continuous-flow-left-ventricular-assist-device-implantation
#1
Nastasya Volkovicher, Chitaru Kurihara, Andre Critsinelis, Masashi Kawabori, Tadahisa Sugiura, Marcos Manon, Andrew B Civitello, Jeffrey A Morgan
Left ventricular assist devices (LVADs) have become a preferred treatment option for patients with end-stage heart failure when used as a bridge to transplant or as a destination therapy. However, the association between small body size and postoperative outcomes for continuous-flow (CF) LVAD recipients is still being studied. We sought to determine whether body surface area (BSA) is associated with patient outcomes after CF-LVAD implantation. The study cohort of our single-center, retrospective review consisted of all patients (n = 526) who underwent CF-LVAD implantation (n = 403 HeartMate II, n = 123 HeartWare) between November 2003 and March 2016 regardless of indication...
September 20, 2017: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/28918555/prognostic-factors-for-mortality-in-middle-aged-and-older-hemodialysis-patients-a-5-year-observational-study
#2
Kojiro Nagai, Motokazu Matsuura, Kenji Tsuchida, Hiro-Omi Kanayama, Toshio Doi, Jun Minakuchi
Clinical guidelines for hemodialysis therapy have been described in an evidence-based manner with most evidence from randomized control trials or retrospective studies in which all generations of the hemodialysis patients were enrolled. Therefore, the question still remains whether these guidelines can be applied to increasing older patients. This study is an observational study, including 735 patients who received maintenance hemodialysis in April 2006. At baseline, the participants' age was 62.1 ± 12...
September 16, 2017: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/28905112/extracorporeal-membrane-oxygenation-in-spina-bifida-and-h1n1-induced-acute-respiratory-distress-syndrome
#3
Oliver Jansen, Oliver Kamp, Christian Waydhas, Valentin Rausch, Thomas Armin Schildhauer, Justus Strauch, Dirk Buchwald, Uwe Hamsen
Acute respiratory distress syndrome (ARDS) is characterized as an acute hypoxemic and/or hypercapnic respiratory failure seen in critically ill patients and is still, although decreased over the past few years, associated with high mortality. Furthermore, ARDS may be a life-threatening complication of H1N1 pneumonia. We report on a 45-year-old spina bifida patient with confirmed H1N1 influenza virus infection causing acute respiratory failure, who was successfully weaned from 42-day veno-venous extracorporeal membrane oxygenation (vv-ECMO) treatment with an excellent outcome...
September 13, 2017: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/28900738/novel-temporary-left-ventricular-assist-system-with-hydrodynamically-levitated-bearing-pump-for-bridge-to-decision-initial-preclinical-assessment-in-a-goat-model
#4
Satoru Kishimoto, Yoshiaki Takewa, Tomonori Tsukiya, Toshihide Mizuno, Kazuma Date, Hirohito Sumikura, Yutaka Fujii, Kentaro Ohnuma, Konomi Togo, Nobumasa Katagiri, Noritsugu Naito, Yuichiro Kishimoto, Yoshinobu Nakamura, Motonobu Nishimura, Eisuke Tatsumi
The management of heart failure patients presenting in a moribund state remains challenging, despite significant advances in the field of ventricular assist systems. Bridge to decision involves using temporary devices to stabilize the hemodynamic state of such patients while further assessment is performed and a decision can be made regarding patient management. We developed a new temporary left ventricular assist system employing a disposable centrifugal pump with a hydrodynamically levitated bearing. We used three adult goats (body weight, 58-68 kg) to investigate the 30-day performance and hemocompatibility of the newly developed left ventricular assist system, which included the pump, inflow and outflow cannulas, the extracorporeal circuit, and connectors...
September 12, 2017: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/28894963/efficacy-of-hemofiltration-with-pepa-membrane-for-il-6-removal-in-a-rat-sepsis-model
#5
Hayata Maeda, Narumi Tomisawa, Yoichi Jimbo, Norikazu Harii, Kenichi Matsuda
Recently, intensive care physicians have focused on continuous hemodiafiltration with a cytokine-adsorbing hemofilter in the treatment of sepsis. We aimed to establish extracorporeal circulation in a rat sepsis model to evaluate the cytokine removal properties of mini-modules using two types of membrane materials. Rats were divided into polyester polymer alloy (PEPA) and cellulose triacetate (CTA) groups as membrane materials of mini-modules. One hour after 0.1 mg/kg of lipopolysaccharide administration, continuous hemofiltration (CHF) was started in each group...
September 11, 2017: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/28887736/a-comparison-among-three-different-apheretic-techniques-for-treatment-of-hyperbilirubinemia
#6
Davide Viggiano, Emanuela de Pascale, Gaia Marinelli, Corrado Pluvio
Liver failure is associated to high mortality due to the accumulation of protein-bound metabolites, such as bilirubin, not removed by conventional hemodialysis. Different methods can efficiently remove them, such as the molecular adsorbent recirculating system (MARS), plasma exchange (PEX), and bilirubin or plasma adsorption perfusion (PAP). No direct comparison exists between MARS, PEX and PAP, and current guidelines do not specify which method (and when) to use. We have retrospectively evaluated MARS, PEX and PAP in their effectiveness in lowering plasma bilirubin concentration, and their effects on liver and kidney function...
September 8, 2017: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/28887718/measurement-of-hemodynamic-changes-with-the-axial-flow-blood-pump-installed-in-descending-aorta
#7
Eiji Okamoto, Tetsuya Yano, Hidekazu Miura, Yasuyuki Shiraishi, Tomoyuki Yambe, Yoshinori Mitamura
We have developed various axial flow blood pumps to realize the concept of the Valvo pump, and we have studied hemodynamic changes under cardiac assistance using an axial flow blood pump in series with the natural heart. In this study, we measured hemodynamic changes of not only systemic circulation but also cerebral circulation and coronary circulation under cardiac support using our latest axial flow blood pump placed in the descending aorta in an acute animal experiment. The axial flow blood pump was installed at the thoracic descending aorta through a left thoracotomy of a goat (43...
September 8, 2017: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/28887708/long-term-clinical-results-of-acute-myocardial-infarction-at-the-left-main-trunk-requiring-percutaneous-cardiopulmonary-support
#8
Takashi Yamauchi, Takafumi Masai, Kenji Fujii, Yoshiki Sawa, Shinya Shirai, Mitsunori Kamigaki, Naofumi Itou
The clinical results of patients with acute myocardial infarction (AMI) at the left main trunk (LMT) remain unclear, especially in cases requiring percutaneous cardiopulmonary support (PCPS). Twenty seven cases of AMI at the LMT requiring emergent PCPS were retrospectively investigated. These 27 patients were aged 44-83 years (65.6 ± 8.6 years) and 20 (81.5%) were men. Peak creatine kinase (CK) leakage ranged from 538 to 34,010 IU/l (13,553 ± 7656 IU/l). Eight (29.6%) patients were discharged without mechanical support...
September 8, 2017: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/28879605/in-vitro-evaluation-of-limitations-and-possibilities-for-the-future-use-of-intracorporeal-gas-exchangers-placed-in-the-upper-lobe-position
#9
Erin Schumer, Klaus Höffler, Christian Kuehn, Mark Slaughter, Axel Haverich, Bettina Wiegmann
The lack of donor organs has led to the development of alternative "destination therapies", such as a bio-artificial lung (BA) for end-stage lung disease. Ultimately aiming at a fully implantable BA, general capabilities and limitations of different oxygenators were tested based on the model of BA positioning at the right upper lobe. Three different-sized oxygenators (neonatal, paediatric, and adult) were tested in a mock circulation loop regarding oxygenation and decarboxylation capacities for three respiratory pathologies...
September 6, 2017: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/28871334/role-of-percutaneous-veno-arterial-extracorporeal-membrane-oxygenation-as-bridge-to-left-ventricular-assist-device
#10
Koichi Toda, Tomoyuki Fujita, Osamu Seguchi, Masanobu Yanase, Takeshi Nakatani
Percutaneous veno-arterial extracorporeal membrane oxygenation (VA-ECMO) provides emergency circulatory support for cardiogenic shock patients and is used as a bridge to a left ventricular assist device (LVAD). The purpose of this study was to determine risk factors for LVAD implantation in patients who required percutaneous VA-ECMO as a bridge to long-term LVAD. We retrospectively investigated 32 consecutive LVAD patients who required percutaneous VA-ECMO as a bridge to long-term LVAD. Twenty-nine patients (91%) were intubated, and their serum creatinine and total bilirubin levels before LVAD implantation were 2...
September 4, 2017: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/28864998/sequential-use-of-extracorporeal-devices-to-avoid-mechanical-ventilation-in-a-patient-with-complicated-pulmonary-fibrosis
#11
L O Harnisch, O Moerer
Extracorporeal lung assist devices are widely used these days for a growing number of indications. We report the case of a patient managed with three different flow-range devices sequentially, enabling us to avoid mechanical ventilation. Handling and ethics of this approach are discussed.
September 1, 2017: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/28864904/veno-veno-arterial-extracorporeal-membrane-oxygenation-for-acute-respiratory-distress-syndrome-with-septic-induced-cardiomyopathy-due-to-severe-pulmonary-tuberculosis
#12
Seok In Lee, Hyun Joong Hwang, So Young Lee, Chang Hyu Choi, Chul-Hyun Park, Kook Yang Park, Yu Jin Kim
We describe the rare experience of veno-veno-arterial (VVA) extracorporeal membrane oxygenation (ECMO) in a patient with acute respiratory distress syndrome and septic-induced cardiomyopathy due to pulmonary tuberculosis (TB). A 24-year-old male patient who developed septic-induced cardiomyopathy secondary to pulmonary TB was administered veno-arterial (VA) ECMO for cardiac support. Six days later, the ECMO configuration mode was changed from VA to VVA to improve hypoxemia of the upper body and to prevent further lung injury...
September 1, 2017: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/28856453/long-term-results-of-birmingham-hip-resurfacing-arthroplasty-in-asian-patients
#13
Keisuke Uemura, Masaki Takao, Hidetoshi Hamada, Takashi Sakai, Kenji Ohzono, Nobuhiko Sugano
Several reports have shown good long-term results with the Birmingham hip resurfacing (BHR) arthroplasty, but little is known about the results in Asian countries where there is a high prevalence of osteonecrosis and developmental dysplasia of the hip, and many females with small femoral head sizes. Therefore, we retrospectively evaluated the long-term clinical results of the BHR in 112 Japanese patients (53 males and 59 females-130 hips) with an average age of 52 years. Implant survivorship was analyzed using the Kaplan-Meier method with the endpoint being revision for any reason...
August 30, 2017: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/28821973/bilirubin-in-the-early-course-of-venovenous-extracorporeal-membrane-oxygenation-support-for-refractory-ards
#14
Chiara Lazzeri, Manuela Bonizzoli, Giovanni Cianchi, Stefano Batacchi, Marco Chiostri, Giorgio Enzo Fulceri, Laura Tadini Buoninsegni, Adriano Peris
Bilirubin is known as a marker of hepatic dysfunction and is incorporated in scoring algorithms to assess prognosis in critically ill patients. No data are so far available on the prognostic role of hepatic dysfunction in patients with severe ARDS on venovenous extracorporeal membrane oxygenation (VV-ECMO) support. In 112 consecutive patients with severe ARDS treated with VV-ECMO, we aimed at assessing whether increased bilirubin during the first 72 h could affect early death. Increased serum bilirubin (≥1...
August 18, 2017: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/28785829/erratum-to-development-of-in-vivo-tissue-engineered-microvascular-grafts-with-an-ultra-small-diameter-of-0-6%C3%A2-mm-microbiotubes-acute-phase-evaluation-by-optical-coherence-tomography-and-magnetic-resonance-angiography
#15
Daizo Ishii, Jun-Ichiro Enmi, Takeshi Moriwaki, Hastue Ishibashi-Ueda, Mari Kobayashi, Shinichi Iwana, Hidehiro Iida, Tetsu Satow, Jun C Takahashi, Kaoru Kurisu, Yasuhide Nakayama
No abstract text is available yet for this article.
August 7, 2017: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/28785828/differences-in-tissue-oxygenation-and-changes-in-total-hemoglobin-signal-strength-in-the-brain-liver-and-lower-limb-muscle-during-hemodialysis
#16
Susumu Ookawara, Kiyonori Ito, Yuichiro Ueda, Haruhisa Miyazawa, Hideyuki Hayasaka, Masaya Kofuji, Takayuki Uchida, Hiroki Ishii, Mitsutoshi Shindo, Taisuke Kitano, Akinori Aomatsu, Keiji Hirai, Yoshio Kaku, Taro Hoshino, Kaoru Tabei, Yoshiyuki Morishita
Near-infrared spectroscopy has been used to measure regional saturation of oxygen (rSO2) based on the total hemoglobin (t-Hb) signal strength. To date, few studies have investigated the changes of systemic oxygenation and t-Hb signal strength during hemodialysis (HD). This study aimed to (1) monitor rSO2 and t-Hb signal strength in the brain, liver, and lower-limb muscle during HD and (2) clarify the differences in rSO2 and t-Hb signal strength in each compartment. Fifty-three patients receiving 4-h HD were included and divided into three groups according to the compartments in which tissue oxygenation was measured as follows: brain (n = 44), liver (n = 42), and lower-limb muscle (n = 40)...
August 7, 2017: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/28776092/hepatocytic-differentiation-of-ips-cells-on-decellularized-liver-tissue
#17
Mitsuhi Hirata, Tetsuji Yamaoka
Decellularized tissues (DETs) have been attracting great attention as scaffolds for tissue-engineering approaches. Recently, some studies have reported that decellularized liver tissues (DLT) can provide an excellent environment for the hepatocytic differentiation of hepatic stem/progenitor cells that were already committed to the hepatocyte lineage. However, the effects of DLT on the hepatocytic differentiation of induced pluripotent stem cells (iPSs) have not yet been established. Here we studied the hepatocytic differentiation of iPSs on DLT and decellularized heart tissues (DHT) in order to determine the tissue-specific effects of DETs on iPSs differentiation...
August 3, 2017: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/28761992/novel-technique-for-airless-connection-of-artificial-heart-to-vascular-conduits
#18
Jamshid H Karimov, Shengqiang Gao, Raymond Dessoffy, Gengo Sunagawa, Martin Sinkewich, Patrick Grady, Shiva Sale, Nader Moazami, Kiyotaka Fukamachi
Successful implantation of a total artificial heart relies on multiple standardized procedures, primarily the resection of the native heart, and exacting preparation of the atrial and vascular conduits for pump implant and activation. Achieving secure pump connections to inflow/outflow conduits is critical to a successful outcome. During the connection process, however, air may be introduced into the circulation, traveling to the brain and multiple organs. Such air emboli block blood flow to these areas and are detrimental to long-term survival...
July 31, 2017: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/28755017/investigation-of-the-influence-of-fluid-dynamics-on-thrombus-growth-at-the-interface-between-a-connector-and-tube
#19
Yuki Matsuhashi, Kei Sameshima, Yoshiki Yamamoto, Mitsuo Umezu, Kiyotaka Iwasaki
Thrombus formation at the interface between connectors and tubes is a potential risk factor for complications. We investigated time-dependent relationships between formation of thrombus and hemodynamic factors at the interface between connectors and tubes using optical coherence tomography (OCT) under pulsatile flow. A swept-source OCT with the center wavelength of 1330 nm was employed. The sequential process of thrombus formation at the interface of connectors and tubes in the inlet and outlet was investigated...
July 28, 2017: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/28755016/numerical-investigation-of-oxygen-transport-by-hemoglobin-based-carriers-through-microvessels
#20
Toru Hyakutake, Takumi Kishimoto
The small size of hemoglobin-based oxygen carriers (HBOCs) may expand the realm of new treatment possibilities for various circulatory diseases. The parametric evaluation of HBOC performance for oxygen transport within tissue is essential for effectively characterizing its performance for each circulatory disease assessed. Thus, the overarching objective of this present study was to numerically investigate the reaction-diffusion phenomenon of oxygenated HBOCs and oxygen on tissues through microvessels. We considered dissociation rate coefficients, oxygen affinity, and diffusion coefficients due to Brownian motion as the biophysical parameters for estimating HBOC performance for oxygen transport...
July 28, 2017: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
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